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https://www.readbyqxmd.com/read/29930886/kikuchi-fujimoto-disease-in-a-young-african-american-male
#1
Ahmed Zaghloul, Corina Iorgoveanu, Andrew Polio, Aakash Desai
Kikuchi-Fujimoto disease (KFD), also known as histiocytic necrotizing lymphadenitis, is an extremely rare, self-limiting disorder which typically presents with fever and painful, unilateral cervical lymphadenopathy in previously healthy individuals. Here, we describe a case of KFD which initially presented with fever of unknown origin. Due to its non-specific symptoms and low incidence, KFD poses a diagnostic conundrum for clinicians. Awareness of this disease entity is the key for prompt diagnosis and treatment...
April 19, 2018: Curēus
https://www.readbyqxmd.com/read/29925658/the-mtase-like-domain-of-chikungunya-virus-nsp2-inhibits-the-interferon-response-by-promoting-the-nuclear-export-of-stat1
#2
Giel P Göertz, Kristin L McNally, Shelly J Robertson, Sonja M Best, Gorben P Pijlman, Jelke J Fros
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that has evolved effective mechanisms to counteract the type I interferon (IFN) response. Upon viral recognition, cells secrete IFNs which signal through transmembrane receptors (IFNAR) to phosphorylate STAT proteins (pSTAT). pSTAT dimers are transported into the nucleus by importin-α5 and activate the transcription of IFN stimulated genes (ISGs) increasing cellular resistance to infection. Subsequently, STAT proteins are shuttled back into the cytoplasm by exportin CRM1...
June 20, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29924054/long-term-prognosis-treatment-and-outcome-of-patients-with-fever-of-unknown-origin-in-whom-no-diagnosis-was-made-despite-extensive-investigation-a-questionnaire-based-study
#3
Catharina M Mulders-Manders, Celeste Engwerda, Anna Simon, Jos W M van der Meer, Chantal P Bleeker-Rovers
In 30-50% of patients with fever of unknown origin (IUO) no explanation for the fever can be found. Prognosis and effects of empirical treatment of these patients are largely unknown.With this retrospective, questionnaire based corort study in all unexplained FUO patients in an expert center between 2003 and 2014 we studied mortality and outcome.In 131 of 274 FUO patients, FUO remained unexplained. Ninety-nine of them responded to the long-term follow up questionnaire. Adter a median duration of follow-up of 60 months, spontaneous remission of fever occured in 47...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29923822/investigation-of-the-role-of-gbf1-in-the-replication-of-positive-sense-single-stranded-rna-viruses
#4
Juliette Ferlin, Rayan Farhat, Sandrine Belouzard, Laurence Cocquerel, Antoine Bertin, Didier Hober, Jean Dubuisson, Yves Rouillé
GBF1 has emerged as a host factor required for the replication of positive-sense single-stranded RNA viruses of different families, but its mechanism of action is still unknown. GBF1 is a guanine nucleotide exchange factor for Arf family members. Recently, we identified Arf4 and Arf5 (class II Arfs) as host factors required for the replication of hepatitis C virus (HCV), a GBF1-dependent virus. To assess whether a GBF1/class II Arf pathway is conserved among positive-sense single-stranded RNA viruses, we investigated yellow fever virus (YFV), Sindbis virus (SINV), coxsackievirus B4 (CVB4) and human coronavirus 229E (HCoV-229E)...
June 20, 2018: Journal of General Virology
https://www.readbyqxmd.com/read/29921527/hypomethylating-agents-associated-infections-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#5
Liat Shargian-Alon, Ronit Gurion, Pia Raanani, Dafna Yahav, Anat Gafter-Gvili
BACKGROUND: The reported data regarding the effects of hypomethylating agents (HMAs) on the risk of infections seem to be poorly documented and heterogeneous. We conducted a systematic review and meta-analysis of all randomized controlled trials comparing HMA-containing regimens with any other regimen administered to patients with myeloid neoplasms. MATERIALS AND METHODS: A comprehensive search was conducted until February 2018. Two reviewers appraised the quality of the trials and the extracted data...
May 28, 2018: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/29915799/a-case-of-severe-encephalitis-while-on-pd-1-immunotherapy-for-recurrent-clear-cell-ovarian-cancer
#6
Morgan Burke, Melissa Hardesty, Wayne Downs
Recurrent clear cell ovarian carcinoma is a difficult to treat condition and early trial data has suggested a possible role for immune checkpoint inhibitors. Nivolumab is an anti-PD-1 immunotherapy that has been used in this setting. While immune related toxicity of these agents has been well described, the occurrence of immune specific neurotoxicity is thought to be rare. We present a case of severe encephalitis while on PD-1 immunotherapy for a recurrent ovarian clear cell cancer and we believe this to be the first such reported case associated with the use of PD-1 inhibitor monotherapy...
May 2018: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/29912241/-decision-making-issues-in-the-clinical-management-of-pericarditis-a-statement-of-the-italian-association-of-hospital-cardiologists-anmco
#7
Massimo Imazio, Antonio Brucato, Giuseppe Di Tano, Stefano Urbinati, Michele Massimo Gulizia, Domenico Gabrielli, Andrea Di Lenarda
Acute pericarditis is not uncommon in clinical practice and may occur either as isolated disease or as a manifestation of another disease (known or still unknown). The etiology is varied and complex and a clinically-oriented approach to management is possible by identifying initial presentation features of high risk (risk of complications or specific disease: fever >38°C, subacute course without acute chest pain, large pericardial effusion, cardiac tamponade, and lack of response to empiric anti-inflammatory therapy), that suggest admission and additional diagnostic evaluation...
April 2018: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/29911161/hantaviruses-and-a-neglected-environmental-determinant
#8
REVIEW
Alexandro Guterres, Elba Regina Sampaio de Lemos
Most human pathogenic hantaviruses cause severe hemorrhagic fevers with a high rate of fatalities, such as occurs due to the genotypes causing hantavirus cardiopulmonary syndrome carried by the New World Sigmodontinae and Neotominae rodents. An increasing number of outbreaks and the possibility of cases spreading over international borders have led to greater interest in these viruses and the environmental determinants that facilitate their transmission. Rodents, shrews, moles and bats act as reservoir hosts of hantaviruses, and within the hantavirus transmission flow, the prevalence and distribution of infection in reservoir hosts is influenced by a range of factors...
June 2018: One Health
https://www.readbyqxmd.com/read/29907526/invasive-eeg-electrodes-in-presurgical-evaluation-of-epilepsies-systematic-analysis-of-implantation-video-eeg-monitoring-and-explantation-related-complications-and-review-of-literature
#9
Laurent M Willems, Philipp S Reif, Andrea Spyrantis, Adriano Cattani, Thomas M Freiman, Volker Seifert, Marlies Wagner, Se-Jong You, Susanne Schubert-Bast, Sebastian Bauer, Karl Martin Klein, Felix Rosenow, Adam Strzelczyk
INTRODUCTION: Stereoelectroencephalography (sEEG) is a diagnostic procedure for patients with refractory focal epilepsies that is performed to localize and define the epileptogenic zone. In contrast to grid electrodes, sEEG electrodes are implanted using minimal invasive operation techniques without large craniotomies. Previous studies provided good evidence that sEEG implantation is a safe and effective procedure; however, complications in asymptomatic patients after explantation may be underreported...
June 13, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29907390/clinical-characteristics-of-citrobacter-meningitis-in-adults-high-incidence-in-patients-with-a-postneurosurgical-state-and-strains-not-susceptible-to-third-generation-cephalosporins
#10
Chia-Yi Lien, Jun-Jun Lee, Chun-Chih Chien, Chi-Ren Huang, Cheng-Hsien Lu, Wen-Neng Chang
Adult bacterial meningitis (ABM) caused by Citrobacter (C.) infection is very uncommon and the clinical characteristics of this specific infectious syndrome have not been analyzed in the literature. The clinical characteristics of six Citrobacter ABM patients collected during a study period of 30 years (1986-2015) were enrolled, and they accounted for 1.1% (6/540) of our ABM patients. In this study, a total of 14 patients with Citrobacter ABM (six collected from our hospital and eight from the literature) were included for analysis...
June 12, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29902174/prognostic-value-of-quicksofa-as-a-predictor-of-28-day-mortality-among-febrile-adult-patients-presenting-to-emergency-departments-in-dar-es-salaam-tanzania
#11
Noémie Boillat-Blanco, Zainab Mbarack, Josephine Samaka, Tarsis Mlaganile, Aline Mamin, Blaise Genton, Laurent Kaiser, Thierry Calandra, Valérie D'Acremont
BACKGROUND: Quick Sequential Organ Failure Assessment (qSOFA) is a three-item clinical instrument for bedside identification of sepsis patients at risk of poor outcome. qSOFA could be a valuable triage tool in emergency departments of low-income countries, yet its performance in resource-limited settings remains unknown. The prognostic accuracy of qSOFA for 28-day all-cause mortality in febrile adults treated at the EDs in a low-income country was evaluated. METHODS: Retrospective analysis of a prospective cohort study of consecutive patients (≥18 years) with fever (tympanic temperature ≥38°C and fever ≤7 days) who presented between July 2013 and May 2014 at four emergency departments in Dar es Salaam, Tanzania...
2018: PloS One
https://www.readbyqxmd.com/read/29901607/membranoproliferative-glomerulonephritis-like-findings-for-tafro-syndrome-associated-with-an-anterior-mediastinal-tumor-a-case-report
#12
Yoshitaka Furuto, Hirotsugu Hashimoto, Hajime Horiuti, Yuko Shibuya
RATIONALE: TAFRO syndrome is a systemic inflammatory disease proposed recently from Japan. The cause of TAFRO syndrome is unclear. Moreover, the disease characteristics and kidney pathology are yet unknown well and there are few cases. Herein, we report a patient with TAFRO syndrome and present the features of the renal histopathology. PATIENT CONCERNS: A 55-year-old woman presented to our hospital with the main complaint of subacute dyspnoea. DIAGNOSIS: Physical findings included a low-grade fever and generalised oedema...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29901588/clinical-analysis-of-215-consecutive-cases-with-fever-of-unknown-origin-a-cohort-study
#13
Yong-Zhi Zhai, Xin Chen, Xin Liu, Zhi-Qiang Zhang, Hong-Ju Xiao, Gang Liu
Fever of unknown origin (FUO) is a frequently observed phenomenon in clinical practice. The present study was aimed to investigate potential causes of FUO, thereby improving clinical diagnosis of this disorder.In this retrospective study, clinical data were collected from 215 patients who were diagnosed with FUO between January 2009 and December 2010, and an 18 to 36 months follow-up visit was also performed for these patients.Among these FUO cases, the most common causes of the disease were infectious diseases (IDs) (42...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29899035/prostaglandin-transporter-oatp2a1-slco2a1-is-essential-for-body-temperature-regulation-during-fever
#14
Yoshinobu Nakamura, Takeo Nakanishi, Hiroaki Shimada, Junya Shimizu, Rika Aotani, Shio Maruyama, Kei Higuchi, Takashi Okura, Yoshiharu Deguchi, Ikumi Tamai
Prostaglandin E2 (PGE2 ) in the hypothalamus is a principal mediator of the febrile response. However, the role of organic anion transporting polypeptide 2A1 (OATP2A1/ SLCO2A1 ), a prostaglandin transporter, in facilitating this response is unknown. Here, we investigated the effect of Slco2a1 deficiency on the body core temperature (Tc) and on the PGE2 concentration in hypothalamus interstitial fluid ( C isf ) and CSF ( C csf ) of lipopolysaccharide (LPS; 100 μg/kg, i.p.)-treated mice of both sexes. Slco2a1 -/- mice did not develop a febrile response...
June 13, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29898719/adherence-to-ebola-specific-malaria-case-management-guidelines-at-health-facilities-in-guinea-during-the-west-african-ebola-epidemic
#15
Ian Hennessee, Timothée Guilavogui, Alioune Camara, Eric S Halsey, Barbara Marston, Deborah McFarland, Matthew Freeman, Mateusz M Plucinski
BACKGROUND: Malaria case management in the context of the 2014-2016 West African Ebola virus disease (EVD) epidemic was complicated by a similar initial clinical presentation of the two diseases. In September 2014, the World Health Organization (WHO) released recommendations titled, "Guidance on temporary malaria control measures in Ebola-affected countries", which aimed at reducing the risk of EVD transmission and improving malaria outcomes. This guidance recommended malaria diagnostic testing of fever cases only if adequate personal protective equipment (PPE) was available, defined as examination gloves, face shield, disposable gown, boots, and head cover; otherwise presumptive anti-malarial treatment was recommended...
June 14, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29895396/porcine-reproductive-and-respiratory-syndrome-virus-induces-concurrent-elevation-of-high-mobility-group-box-1-protein-and-pro-inflammatory-cytokines-in-experimentally-infected-piglets
#16
D Senthilkumar, K Rajukumar, Manoj Kumar, S Kalaiyarasu, D Shrivastava, M Katare, D D Kulkarni, V P Singh
Porcine Reproductive and Respiratory Syndrome (PRRS), caused by PRRS virus (PRRSV), is one of the most important devastating diseases of pigs, characterized by reproductive failure in sows, and respiratory disease with heavy mortality in piglets. PRRS virus has been reported to elevate the levels of proinflammatory cytokines in the serum of infected pigs. High Mobility Group Box-1 (HMGB-1) protein is a cellular biomolecule belonging to the Danger Associated Molecular Patterns (DAMP) family, which stimulates immune cells to release pro-inflammatory cytokines upon release out of cells...
June 9, 2018: Cytokine
https://www.readbyqxmd.com/read/29886217/contemporary-results-of-surgical-management-of-peripheral-mycotic-aneurysms
#17
Gg Salzler, B Long, Ed Avgerinos, Ra Chaer, S Leers, E Hager, Ms Makaroun, Mh Eslami
OBJECTIVE: Mycotic aneurysms of the extremities occur infrequently but can cause severe life and limb complications. Traditional treatment typically includes debridement and revascularization, though in select patients ligation may be well tolerated. We reviewed our experience with these aneurysms treated with these two modalities. METHODS: A retrospective review of patients treated for peripheral mycotic aneurysms at one institution from January 2005 to December 2015 was performed under an Institutional Review Board-approved protocol...
June 7, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29883335/-cutaneous-polyarteritis-nodosa
#18
Monika Turska, Jolanta Parada-Turska
Cutaneous polyarteritis nodosa is a rare disease that affects vessels of the deep skin and the subcutaneous tissue. Its etiopathology remains unknown. It predominantly affects skin, and the main cutaneous symptoms are subcutaneous nodules, livedo reticularis, and ulcerations that are mainly located on legs. Cutaneous polyarteritis nodosa can also cause extracutaneous symptoms (fever, malaise, myalgias, arthralgias, neuropathy). It is a chronic benign disease with a relapsing course. Diagnostic criteria for this disease were recently proposed and both clinical and typical histological features must be present to confirm the diagnosis...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29874812/tumor-necrosis-factor-receptor-associated-factor-5-interacts-with-the-ns3-protein-and-promotes-classical-swine-fever-virus-replication
#19
Huifang Lv, Wang Dong, Kangkang Guo, Mingxing Jin, Xiaomeng Li, Cunfa Li, Yanming Zhang
Classical swine fever, caused by classical swine fever virus (CSFV), is a highly contagious and high-mortality viral disease, causing huge economic losses in the swine industry worldwide. CSFV non-structural protein 3 (NS3), a multifunctional protein, plays crucial roles in viral replication. However, how NS3 exactly exerts these functions is currently unknown. Here, we identified tumor necrosis factor receptor-associated factor 5 (TRAF5) as a novel binding partner of the NS3 protein via yeast two-hybrid, co-immunoprecipitation and glutathione S -transferase pull-down assays...
June 5, 2018: Viruses
https://www.readbyqxmd.com/read/29872872/acute-septic-arthritis-of-shoulder-joint-caused-by-aeromonas-veronii-biotype-sobria
#20
Dexin Wang, Fanggui Sun, Zheng Li, Yutong Hu, Rongming Xu
We present the case of a 91-year-old woman who presented with a 2‑day history of progressive pain and immobility of the right shoulder joint after fever of unknown etiology. Aeromonas sobria was isolated from a culture of purulent synovial fluid. The clinical condition gradually improved with the application of appropriate antibiotics and no surgical intervention was necessary. This report indicates that acute septic arthritis may result from Aeromonas veronii biotype sobria infections in healthy people...
June 5, 2018: Der Orthopäde
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