keyword
https://read.qxmd.com/read/38070093/the-photothrombotic-model-of-ischemic-stroke
#21
JOURNAL ARTICLE
David E Wong Zhang, Shenpeng R Zhang, Hyun Ah Kim, Christopher G Sobey, T Michael De Silva
Stroke is a major cause of morbidity worldwide; yet, there is a lack of treatment options to address post-stroke cognitive and motor impairment, thus there is an urgency for developing neuroprotective and restorative therapies. Much of our fundamental understanding of stroke pathology has been derived from animal models. The photothrombotic model of ischemic stroke is commonly used to study cellular and molecular mechanisms of neurodegeneration, test functional/cognitive outcomes, identify important biomarkers, and assess the effectiveness of novel therapies...
2024: Methods in Molecular Biology
https://read.qxmd.com/read/38041607/the-role-of-the-glymphatic-system-and-perivascular-spaces-as-a-potential-biomarker-for-post-stroke-epilepsy
#22
REVIEW
Gernot Hlauschek, John-Paul Nicolo, Benjamin Sinclair, Meng Law, Clarissa L Yasuda, Fernando Cendes, Morten Ingvar Lossius, Patrick Kwan, Lucy Vivash
Stroke is one of the most common causes of acquired epilepsy, which can also result in disability and increased mortality rates particularly in elderly patients. No preventive treatment for post-stroke epilepsy is currently available. Development of such treatments has been greatly limited by the lack of biomarkers to reliably identify high risk patients. The glymphatic system, including perivascular spaces (PVS) is the brain's waste clearance system and enlargement or asymmetry of PVS (ePVS) is hypothesized to play a significant role in the pathogenesis of several neurological conditions...
December 2, 2023: Epilepsia Open
https://read.qxmd.com/read/38008901/incidence-and-risk-factors-of-post-stroke-seizures-and-epilepsy-systematic-review-and-meta-analysis
#23
JOURNAL ARTICLE
Aathmika Nandan, Yi Mei Zhou, Lindsay Demoe, Adnan Waheed, Puneet Jain, Elysa Widjaja
OBJECTIVE: Due to variability in reports, the aim of this meta-analysis was to evaluate the incidence and risk factors of post-stroke early seizures (ES) and post-stroke epilepsy (PSE). METHODS: The MEDLINE, EMBASE and Web of Science databases were searched for post-stroke ES/PSE articles published on any date up to November 2020. Post-stroke ES included seizures occurring within 7 days of stroke, and PSE included at least one unprovoked seizure. Using random effects models, the incidence and risk factors of post-stroke ES and PSE were evaluated...
November 2023: Journal of International Medical Research
https://read.qxmd.com/read/37994857/interhemispheric-vertical-hemispherotomy-technique-outcome-and-pitfalls-a-bicentric-retrospective-case-series-of-39-cases
#24
JOURNAL ARTICLE
Martin Pilioneta, Hsin-Hung Chen, Emma Losito, Marie Bourgeois, Nicole Chémaly, Monika Eiserman, Lelio Guida, Volodia Dangouloff-Ros, Luca Fumagalli, Anna Kaminska, Nathalie Boddaert, Stéphane Auvin, Rima Nabbout, Christian Sainte-Rose, Thomas Blauwblomme
BACKGROUND AND OBJECTIVES: When seizure onset affects a whole hemisphere, hemispheric disconnections are efficient and safe procedures. However, both lateral peri-insular hemispherotomy and vertical paramedian hemispherotomy approaches report a failure rate around 20%, which can be explained by residual connections giving rise to persistent seizures. In this study, we present the interhemispheric vertical hemispherotomy (IVH), a technical variation of the vertical paramedian hemispherotomy approach, that aims to increase seizure control avoiding residual connections while exposing the corpus callosum...
November 23, 2023: Operative Neurosurgery (Hagerstown, Md.)
https://read.qxmd.com/read/37990261/electronic-field-protocols-for-prehospital-care-quality-improvement-in-lithuania-a-randomized-simulation-based-study
#25
JOURNAL ARTICLE
Ieva Paliokaite, Zilvinas Dambrauskas, Paulius Dobozinskas, Evelina Pukenyte, Aida Mankute-Use, Dinas Vaitkaitis
BACKGROUND: Prehospital emergency care is complex and influenced by various factors, leading to the need for decision-support tools. Studies suggest that cognitive aids improve provider performance and patient outcomes in clinical emergencies. Electronic cognitive aids have rarely been investigated in prehospital care. Therefore, this study aimed to evaluate the effects of the electronic field protocol (eFP) module on performance, adherence to the standard of care, and satisfaction of prehospital care providers in a simulated environment...
November 21, 2023: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://read.qxmd.com/read/37972420/acute-symptomatic-seizures-after-stroke-a-scoping-review-on-primary-prevention-treatment-with-antiseizure-medications-and-drug-discontinuation
#26
REVIEW
Gaetano Zaccara, Simona Lattanzi, Francesco Brigo
AIM: To evaluate and synthesize the evidence and knowledge gaps on primary prevention and treatment of post-stroke acute symptomatic seizures (ASSs) using antiseizure medications (ASMs). METHODS: We systematically searched of EMBASE, MEDLINE (accessed from PubMed), and the Cochrane Central Register of Controlled Trials (CENTRAL) to include randomized, double- or single-blinded trials (RCTs) on primary prophylaxis and treatment of post-stroke ASSs with ASMs. The risk of bias in the included studies was assessed according to the recommendations of the Cochrane Handbook for Systematic Reviews of Interventions...
December 2023: Epilepsy & Behavior: E&B
https://read.qxmd.com/read/37968000/clinical-characteristics-and-outcomes-of-patients-with-post-stroke-epilepsy-protocol-for-an-individual-patient-data-meta-analysis-from-the-international-post-stroke-epilepsy-research-repository-ipserr
#27
JOURNAL ARTICLE
Nishant K Mishra, Patrick Kwan, Tomotaka Tanaka, Katharina S Sunnerhagen, Jesse Dawson, Yize Zhao, Shubham Misra, Selena Wang, Vijay K Sharma, Rajarshi Mazumder, Melissa C Funaro, Masafumi Ihara, John-Paul Nicolo, David S Liebeskind, Clarissa L Yasuda, Fernando Cendes, Terence J Quinn, Zongyuan Ge, Fabien Scalzo, Johan Zelano, Scott E Kasner
INTRODUCTION: Despite significant advances in managing acute stroke and reducing stroke mortality, preventing complications like post-stroke epilepsy (PSE) has seen limited progress. PSE research has been scattered worldwide with varying methodologies and data reporting. To address this, we established the International Post-stroke Epilepsy Research Consortium (IPSERC) to integrate global PSE research efforts. This protocol outlines an individual patient data meta-analysis (IPD-MA) to determine outcomes in patients with post-stroke seizures (PSS) and develop/validate PSE prediction models, comparing them with existing models...
November 15, 2023: BMJ Open
https://read.qxmd.com/read/37903631/incidence-of-altered-level-of-consciousness-in-hemorrhagic-stroke-survivors-associated-factors-from-a-korean-nationwide-study
#28
JOURNAL ARTICLE
Nayeon Ko, Hyun Haeng Lee, Min Kyun Sohn, Deog Young Kim, Yong-Il Shin, Gyung-Jae Oh, Yang-Soo Lee, Min Cheol Joo, So Young Lee, Min-Keun Song, Junhee Han, Jeonghoon Ahn, Won Hyuk Chang, Jongmin Lee, Yun-Hee Kim
OBJECTIVE: This study aimed to demonstrate the incidence of altered level of consciousness (ALOC) after hemorrhagic stroke and identify factors associated with ALOC at 3 months post-stroke. DESIGN: This study used data from a prospective multicenter cohort study conducted in nine hospitals in Korea, and included 1,677 patients with first-ever hemorrhagic stroke. Patients were dichotomized into those with and without ALOC at 3 months post-stroke. Multivariate logistic regression analysis was performed to identify factors associated with subacute to chronic stage ALOC...
October 26, 2023: American Journal of Physical Medicine & Rehabilitation
https://read.qxmd.com/read/37895044/micrornas-as-potential-biomarkers-of-post-traumatic-epileptogenesis-a-systematic-review
#29
REVIEW
Anastasia A Vasilieva, Elena E Timechko, Kristina D Lysova, Anastasia I Paramonova, Alexey M Yakimov, Elena A Kantimirova, Diana V Dmitrenko
Structural or post-traumatic epilepsy often develops after brain tissue damage caused by traumatic brain injury, stroke, infectious diseases of the brain, etc. Most often, between the initiating event and epilepsy, there is a period without seizures-a latent period. At this time, the process of restructuring of neural networks begins, leading to the formation of epileptiform activity, called epileptogenesis. The prediction of the development of the epileptogenic process is currently an urgent and difficult task...
October 19, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37876390/neurological-manifestations-in-hospitalized-geriatric-patients-with-covid-19-at-king-abdulaziz-medical-city-in-jeddah-western-region-saudi-arabia-from-2020-to-2021-a-cross-sectional-study
#30
JOURNAL ARTICLE
Yasir O Marghalani, Abdulrahman H Kaneetah, Muhammad A Khan, Ammar A Albakistani, Sultan G Alzahrani, Abdulbari Kidwai, Khalid W Alansari, Hamid S Alhamid, Muath H Alharbi, Ahmed Attar
Introduction COVID-19 involvement in the nervous system has been reported in many cases. Viral neuroinvasion has multiple routes of entry. Neurological manifestations of COVID-19 can be divided into ones of the central nervous system (CNS), such as headache, dizziness, altered mental status, ataxia, and seizure, and of the peripheral nervous system (PNS), including ageusia, anosmia, acute illness demyelinating polyneuropathy, and neuralgia. Aim and objectives This study aims to observe and report the neurological manifestations in geriatric patients who were diagnosed with COVID-19 at KAMC-J and report the duration of admission to the in-patient and ICU wards...
September 2023: Curēus
https://read.qxmd.com/read/37810288/a-case-of-temporary-occlusion-of-donor-artery-after-secondary-generalized-seizure-in-a-patient-with-superficial-temporal-artery-middle-cerebral-artery-bypass
#31
Tsuyoshi Tsukada, Toru Masuoka, Michiya Kubo
BACKGROUND: To prevent stroke recurrence, a superficial temporal artery-middle cerebral artery (STA-MCA) bypass for atherosclerotic cerebrovascular occlusive disease is performed. Post stroke epilepsy is known as serious sequelae of stroke. Herein, we present a case of a 60-year-old man who underwent STA-MCA bypass for the prevention of stroke recurrence; however, the donor artery was deemed to be temporally occluded secondary to generalized seizure. CASE DESCRIPTION: A 60-year-old man was referred to our hospital with a diagnosis of the left cervical internal carotid artery occlusion presenting with mild aphasia and right hemiparesis...
2023: Surgical Neurology International
https://read.qxmd.com/read/37807253/a-114-long-term-cognitive-sequela-of-intracranial-radiation-therapy-in-a-pediatric-cerebellar-medulloblastoma-survivor
#32
JOURNAL ARTICLE
Pelin Strebler, Andrew Schmitt
OBJECTIVE: Intracranial radiation therapy (IRT) for pediatric brain tumors is associated with late delayed brain injury due to cerebrovascular abnormality, white matter necrosis, demyelination, and gliosis which are irreversible. As a result, persistent cognitive deficits in adulthood emerge which are aggravated by younger age at diagnosis, higher radiation dose, whole brain radiation (WBR), and concurrent chemotherapy. The case is a childhood brain tumor survivor seen 18 years post treatment who displayed cognitive deficits reflecting the cognitive sequela of WBR that overlapped with the anatomical distribution of white matter damage sustained...
October 8, 2023: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://read.qxmd.com/read/37786272/the-daily-patterns-of-emergency-medical-events
#33
JOURNAL ARTICLE
Mary E Helander, Margaret K Formica, Dessa K Bergen-Cico
This study examines population-level daily patterns of time-stamped emergency medical service (EMS) dispatches to establish their situational predictability. Using visualization, sinusoidal regression, and statistical tests to compare empirical cumulative distributions, we analyzed 311,848,450 emergency medical call records from the US National Emergency Medical Services Information System (NEMSIS) for years 2010 through 2022. The analysis revealed a robust daily pattern in the hourly distribution of distress calls across 33 major categories of medical emergency dispatch types...
October 2, 2023: Journal of Biological Rhythms
https://read.qxmd.com/read/37754551/prognostic-value-of-early-electrographic-biomarkers-of-epileptogenesis-in-high-risk-ischaemic-stroke-patients
#34
JOURNAL ARTICLE
Chiara Tatillo, Benjamin Legros, Chantal Depondt, Estelle Rikir, Gilles Naeije, Lise Jodaïtis, Noémie Ligot, Nicolas Gaspard
BACKGROUND AND PURPOSE: Post-stroke epilepsy (PSE) is frequent. Better prediction of PSE would enable individualized management and improve trial design for epilepsy prevention. The aim was to assess the complementary value of continuous electroencephalography (EEG) data during the acute phase compared with clinical risk factors currently used to predict PSE. METHODS: A prospective cohort of 81 patients with ischaemic stroke who received early continuous EEG monitoring was studied to assess the association of early EEG seizures, other highly epileptogenic rhythmic and periodic patterns, and regional attenuation without delta (RAWOD, an EEG pattern of stroke severity) with PSE...
September 27, 2023: European Journal of Neurology
https://read.qxmd.com/read/37735708/protocol-for-a-single-blind-randomized-clinical-trial-to-test-the-efficacy-of-bilateral-transcranial-magnetic-stimulation-on-upper-extremity-motor-function-in-patients-recovering-from-stroke
#35
JOURNAL ARTICLE
Yuan Huang, Ruizhu Lin, Hongyu Li, Yujuan Xu, Fubao Tian, Liangchen Ma, Xiaoli Liu, Shuming Ma, Xiaolong Li, Zheying Lai, Chuanping Bai, Weichun He, Qi Ma, Jingkai Wang, Ning Zhu
BACKGROUND: No consensus currently exists regarding the optimal protocol for repetitive transcranial magnetic stimulation (rTMS) treatment of upper-extremity motor dysfunction after stroke. Studies have shown that combined low- and high-frequency stimulation (LF-HF-rTMS) of the bilateral cerebral hemispheres is more effective than sham stimulation or stimulation of one cerebral hemisphere alone in treating motor dysfunction in the subacute stage of stroke. The efficacy of this protocol in the convalescence phase of stroke has rarely been reported, and its mechanism of action has not been clarified...
September 22, 2023: Trials
https://read.qxmd.com/read/37652474/assessing-the-risk-of-stroke-in-the-elderly-in-the-context-of-long-covid-followed-through-the-lens-of-family-medicine
#36
JOURNAL ARTICLE
Andrada Florina Moldovan, Ioana Moga, Titus Moga, Evelin Claudia Ghitea, Katalin Babes, Timea Claudia Ghitea
BACKGROUND/AIM: Patients infected with COVID-19 may experience a range of acute and chronic neurological disorders. While severe neurological complications like strokes and seizures were less common during the acute or post-COVID period, the long-term effects of COVID-19, known as long COVID, have received limited attention. This study aimed to examine the lasting consequences of SARS-CoV-2 infection and establish potential connections with related diseases. PATIENTS AND METHODS: We followed a group of 157 patients for one year, predominantly from urban areas (61...
2023: In Vivo
https://read.qxmd.com/read/37652135/personalized-functional-imaging-guided-rtms-on-the-superior-frontal-gyrus-for-post-stroke-aphasia-a-randomized-sham-controlled-trial
#37
JOURNAL ARTICLE
Jianxun Ren, Weijing Ren, Ying Zhou, Louisa Dahmani, Xinyu Duan, Xiaoxuan Fu, Yezhe Wang, Ruiqi Pan, Jingdu Zhao, Ping Zhang, Bo Wang, Weiyong Yu, Zhenbo Chen, Xin Zhang, Jian Sun, Mengying Ding, Jianting Huang, Liu Xu, Shiyi Li, Weiwei Wang, Wuxiang Xie, Hao Zhang, Hesheng Liu
BACKGROUND: Aphasia affects approximately one-third of stroke patients and yet its rehabilitation outcomes are often unsatisfactory. More effective strategies are needed to promote recovery. OBJECTIVE: We aimed to examine the efficacy and safety of the theta-burst stimulation (TBS) on the language area in the superior frontal gyrus (SFG) localized by personalized functional imaging, in facilitating post-stroke aphasia recovery. METHODS: This randomized sham-controlled trial uses a parallel design (intermittent TBS [iTBS] in ipsilesional hemisphere vs...
August 29, 2023: Brain Stimulation
https://read.qxmd.com/read/37638459/are-antiepileptic-drugs-effective-for-the-primary-and-secondary-prevention-of-seizures-after-stroke-a-cochrane-review-summary-with-commentary
#38
JOURNAL ARTICLE
Farooq Azam Rathore, Shaikh Nabi Bukhsh Nazir
BACKGROUND: In post stroke patients, seizures can complicate the recovery process and lead to poor outcomes. It is unclear whether antiepileptic drugs (AEDs) can prevent seizures after a stroke. OBJECTIVE: To summarize the evidence on the effects of AEDs on the primary and secondary prevention of post stroke seizures. METHODS: The authors searched the Cochrane Register of Studies and MEDLINE (last search on 9 March 2021), checked the reference lists of articles retrieved and contacted the corresponding authors of the study where needed...
2023: NeuroRehabilitation
https://read.qxmd.com/read/37636014/effect-of-neonatal-seizure-burden-and-etiology-on-the-long-term-outcome-data-from-a-randomized-controlled-trial
#39
JOURNAL ARTICLE
Sara K Trowbridge, Lois O Condie, Jessica R Landers, Ann M Bergin, Patricia E Grant, Kalpathy Krishnamoorthy, Valerie Rofeberg, David Wypij, Kevin J Staley, Janet S Soul
BACKGROUND: Neonatal seizures are common, but the impact of neonatal seizures on long-term neurologic outcome remains unclear. We addressed this question by analyzing data from an early-phase controlled trial of bumetanide to treat neonatal seizures. METHODS: Neonatal seizure burden was calculated from continuous video-EEG data. Neurologic outcome was determined by standardized developmental tests and post-neonatal seizure recurrence. RESULTS: Of 111 enrolled neonates, 43 were randomized to treatment or control groups...
March 2023: Ann Child Neurol Soc
https://read.qxmd.com/read/37635920/stereo-eeg-tailored-resection-in-a-child-with-presumed-perinatal-post-stroke-epilepsy-the-complex-organization-of-epileptogenic-zone
#40
JOURNAL ARTICLE
D Chiarello, G Tumminelli, F Sandrin, C Vilasi, L Castana, G Lo Russo, A Liava, S Francione
INTRODUCTION: Only a few studies have focused on tailored resection in post-stroke epilepsy, in which hemispherectomy and hemispherotomy are the most recognized treatments. CASE DESCRIPTION: We describe the case of a patient with drug-resistant, presumed perinatal, post-stroke epilepsy and moderate right hemiparesis. The seizures were stereotyped, both spontaneous and induced by sudden noises and somatosensory stimuli. Considering the discordant anatomic-electro-clinical data - left perisylvian malacic lesion with electrical onset over the left mesial fronto-central leads - and the patient's functional preservation, SEEG was performed...
2023: Epilepsy & behavior reports
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