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https://www.readbyqxmd.com/read/27857839/fatal-outcome-in-a-hispanic-woman-with-moyamoya-syndrome-and-graves-disease
#1
Julian Choi, Perin Suthakar, Farbod Farmand
: We describe the case of a young Hispanic female who presented with thyrotoxicosis with seizures and ischemic stroke. She was diagnosed with a rare vasculopathy - moyamoya syndrome. After starting antithyroid therapy, her neurologic symptoms did not improve. Acute neurosurgical intervention had relieved her symptoms in the immediate post-operative period after re-anastomosis surgery. However, 2 post-operative days later, she was found to be in status epilepticus and in hyperthyroid state...
2016: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/27815401/proportion-of-single-chain-recombinant-tissue-plasminogen-activator-and-outcome-after-stroke
#2
Didier Leys, Yannick Hommet, Clémence Jacquet, Solène Moulin, Igor Sibon, Jean-Louis Mas, Thierry Moulin, Maurice Giroud, Sharmila Sagnier, Charlotte Cordonnier, Elisabeth Medeiros de Bustos, Guillaume Turc, Thomas Ronzière, Yannick Bejot, Olivier Detante, Thavarak Ouk, Anne-Marie Mendyk, Pascal Favrole, Mathieu Zuber, Aude Triquenot-Bagan, Ozlem Ozkul-Wermester, Francisco Macian Montoro, Chantal Lamy, Anthony Faivre, Laurent Lebouvier, Camille Potey, Mathilde Poli, Hilde Hénon, Pauline Renou, Nelly Dequatre-Ponchelle, Marie Bodenant, Sabrina Debruxelles, Costanza Rossi, Régis Bordet, Denis Vivien
OBJECTIVE: To determine whether the ratio single chain (sc)/(sc + 2 chain [tc]) recombinant tissue plasminogen activator (rtPA) influences outcomes in patients with cerebral ischemia. METHODS: We prospectively included consecutive patients treated with IV rtPA for cerebral ischemia in 13 stroke centers and determined the sc/(sc + tc) ratio in the treatment administered to each patient. We evaluated the outcome with the modified Rankin Scale (mRS) at 3 months (prespecified analysis) and occurrence of epileptic seizures (post hoc analysis)...
December 6, 2016: Neurology
https://www.readbyqxmd.com/read/27814760/clinical-predictors-of-seizure-recurrence-after-the-first-post-ischemic-stroke-seizure
#3
Hyeon Jin Kim, Kee Duk Park, Kyoung-Gyu Choi, Hyang Woon Lee
BACKGROUND: The number of patients suffering post-stroke seizure after ischemic stroke (PSSi) is quite considerable, especially because ischemic stroke is more prevalent than hemorrhage in the general population. This study aimed to determine the predicting factors for seizure recurrence in ischemic stroke survivors and develop a clinical scoring system for the prediction of risks for seizure recurrence after the first PSSi. METHODS: We reviewed 3792 ischemic stroke patients from the Ewha Stroke Registry...
November 5, 2016: BMC Neurology
https://www.readbyqxmd.com/read/27762527/post-partum-angiopathy-presenting-as-ischemic-stroke
#4
Pooja Gupta, Anshu Rohatgi, Samir Patel
Post-partum angiopathy is grouped within the category of reversible cerebral vasoconstriction syndromes. It is considered to be a rare but under-recognized cause of stroke especially in pregnancy. We present the case of a 24 year old female who presented with hemiparesis and seizure, and turned out to be a case of post partum angiopathy.
September 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27635604/-predictors-of-epilepsy-in-children-after-ischemic-stroke
#5
O A L'vova, L V Shal'kevich, A N Dron', M Yu Lukashchuk, E A Orlova, V V Gusev, E V Suleimanova, A V Sulimov, A I Kudlach
AIM: To determine clinical/instrumental predictors of symptomatic epilepsy after ischemic stroke in children. MATERIAL AND METHODS: One hundred and thirty-six patients, aged 0-15 years, with the diagnosis of ischemic stroke (ICD-10 I63.0-I63.9) were examined. The duration of the study was 18 months - 12 years. Patients were stratified into post-stroke (n=22) and control (n=114) groups, the latter included patients without epilepsy regardless of the presence of convulsive seizures in the acute stage of stroke...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/27583179/clinical-outcome-prediction-in-aneurysmal-subarachnoid-hemorrhage-alterations-in-brain-body-interface
#6
Benjamin W Y Lo, Hitoshi Fukuda, Mark Angle, Jeanne Teitelbaum, R Loch Macdonald, Forough Farrokhyar, Lehana Thabane, Mitchell A H Levine
BACKGROUND: Brain-body associations are essential in influencing outcome in patients with ruptured brain aneurysms. Thus far, there is scarce literature on such important relationships. METHODS: The multicenter Tirilazad database (3551 patients) was used to create this clinical outcome prediction model in order to elucidate significant brain-body associations. Traditional binary logistic regression models were used. RESULTS: Binary logistic regression main effects model included four statistically significant single prognostic variables, namely, neurological grade, age, stroke, and time to surgery...
2016: Surgical Neurology International
https://www.readbyqxmd.com/read/27538600/post-stroke-epilepsy-in-burkina-faso-west-africa
#7
Christian Napon, Anselme Dabilgou, Julie Kyelem, Jean Kaboré
Post-stroke epilepsy (PSE) is defined as "recurrent seizures following stroke with confirmed diagnosis of epilepsy". Our objective was to describe the epidemiological, clinical and therapeutic PSE aspects at the Yalgado Ouedraogo Teaching Hospital, the main reference centre for neurological conditions in Burkina Faso. We conducted a retrospective study from January 2006 to December 2014. The data on thirty-two (32) cases of PSE was collected from a total of 1616 patients hospitalized for stroke, representing a rate of 1...
September 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27399117/association-between-seizures-after-ischemic-stroke-and-stroke-outcome-a-systematic-review-and-meta-analysis
#8
Tao Xu, Shu Ou, Xi Liu, Xinyuan Yu, Jinxian Yuan, Hao Huang, Yangmei Chen
A systematic review and meta-analysis were performed to investigate a potential association between post-ischemic stroke seizures (PISS) and subsequent ischemic stroke (IS) outcome.A systematic search of two electronic databases (Medline and Embase) was conducted to identify studies that explored an association between PISS and IS outcome. The primary and secondary IS outcomes of interest were mortality and disability, respectively, with the latter defined as a score of 3 to 5 on the modified Rankin Scale.A total of 15 studies that were published between 1998 and 2015 with 926,492 participants were examined...
July 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27381481/epilepsy-in-cerebrovascular-diseases-review-of-experimental-and-clinical-data-with-meta-analysis-of-risk-factors
#9
REVIEW
Edoardo Ferlazzo, Sara Gasparini, Ettore Beghi, Chiara Sueri, Emilio Russo, Antonio Leo, Angelo Labate, Antonio Gambardella, Vincenzo Belcastro, Pasquale Striano, Maurizio Paciaroni, Laura Rosa Pisani, Umberto Aguglia
OBJECTIVE: Seizures may occur in close temporal association with a stroke or after a variable interval. Moreover, epilepsy is often encountered in patients with leukoaraiosis. Although early post-stroke seizures have been studied extensively, less attention has been paid to post-stroke epilepsy (PSE) and to epilepsy associated with leukoaraiosis (EAL). The aim of this paper is to review data concerning pathophysiology, prognosis, and treatment of PSE and EAL. METHODS: We performed an extensive literature search to identify experimental and clinical articles on PSE and EAL...
August 2016: Epilepsia
https://www.readbyqxmd.com/read/27365261/efficacy-and-safety-of-non-immersive-virtual-reality-exercising-in-stroke-rehabilitation-evrest-a-randomised-multicentre-single-blind-controlled-trial
#10
Gustavo Saposnik, Leonardo G Cohen, Muhammad Mamdani, Sepideth Pooyania, Michelle Ploughman, Donna Cheung, Jennifer Shaw, Judith Hall, Peter Nord, Sean Dukelow, Yongchai Nilanont, Felipe De Los Rios, Lisandro Olmos, Mindy Levin, Robert Teasell, Ashley Cohen, Kevin Thorpe, Andreas Laupacis, Mark Bayley
BACKGROUND: Non-immersive virtual reality is an emerging strategy to enhance motor performance for stroke rehabilitation. There has been rapid adoption of non-immersive virtual reality as a rehabilitation strategy despite the limited evidence about its safety and effectiveness. Our aim was to compare the safety and efficacy of virtual reality with recreational therapy on motor recovery in patients after an acute ischaemic stroke. METHODS: In this randomised, controlled, single-blind, parallel-group trial we enrolled adults (aged 18-85 years) who had a first-ever ischaemic stroke and a motor deficit of the upper extremity score of 3 or more (measured with the Chedoke-McMaster scale) within 3 months of randomisation from 14 in-patient stroke rehabilitation units from four countries (Canada [11], Argentina [1], Peru [1], and Thailand [1])...
September 2016: Lancet Neurology
https://www.readbyqxmd.com/read/27333721/age-and-gender-differences-in-acute-stroke-hospital-patients
#11
Vanja Bašić Kes, Miljenka-Jelena Jurašić, Iris Zavoreo, Marijana Lisak, Vjekoslav Jelec, Lucija Zadro Matovina
Stroke is the second leading cause of death and the most important cause of adult disability worldwide and in Croatia. In the past, stroke was almost exclusively considered to be a disease of the elderly; however, today the age limit has considerably lowered towards younger age. The aim of this study was to determine age and gender impact on stroke patients in a Croatian urban area during one-year survey. The study included all acute stroke patients admitted to our Department in 2004. A compiled stroke questionnaire was fulfilled during hospitalization by medical personnel on the following items: stroke risk factors including lifestyle habits (smoking and alcohol), pre-stroke physical ability evaluation, stroke evolution data, laboratory and computed tomography findings, outcome data and post-stroke disability assessment...
March 2016: Acta Clinica Croatica
https://www.readbyqxmd.com/read/27259067/reduced-expression-of-ia-channels-is-associated-with-post-ischemic-seizures
#12
Zhigang Lei, Hui Zhang, Yanling Liang, Zao C Xu
PURPOSE: Post-stroke seizures are considered as a major cause of epilepsy in adults. The pathophysiologic mechanisms resulting in post-stroke seizures are not fully understood. The present study attempted to reveal a new mechanism underlying neuronal hyperexcitability responsible to the seizure development after ischemic stroke. METHODS: Transient global ischemia was produced in adult Wistar rats using the 4-vessel occlusion (4-VO) method. The spontaneous behavioral seizures were defined by the Racine scale III-V...
August 2016: Epilepsy Research
https://www.readbyqxmd.com/read/27188341/reduced-tonic-inhibition-after-stroke-promotes-motor-performance-and-epileptic-seizures
#13
Nadine Jaenisch, Lutz Liebmann, Madlen Guenther, Christian A Hübner, Christiane Frahm, Otto W Witte
Stroke survivors often recover from motor deficits, either spontaneously or with the support of rehabilitative training. Since tonic GABAergic inhibition controls network excitability, it may be involved in recovery. Middle cerebral artery occlusion in rodents reduces tonic GABAergic inhibition in the structurally intact motor cortex (M1). Transcript and protein abundance of the extrasynaptic GABAA-receptor complex α4β3δ are concurrently reduced (δ-GABAARs). In vivo and in vitro analyses show that stroke-induced glutamate release activates NMDA receptors, thereby reducing KCC2 transporters and down-regulates δ-GABAARs...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27125597/enhanced-autophagy-signaling-in-diabetic-rats-with-ischemia-induced-seizures
#14
Luoxing Xia, Zhigang Lei, Zhongshan Shi, Dave Guo, Henry Su, Yiwen Ruan, Zao C Xu
Seizures are among the most common neurological sequelae of stroke, and ischemic insult in diabetes notably increases the incidence of seizures. Recent studies indicated that autophagy influences the outcome of stroke and involved in epileptogenesis. However, the association of autophagy and post-ischemic seizures in diabetes remains unclear. The present study aimed to reveal the involvement of autophagy in the seizures following cerebral ischemia in diabetes. Diabetes was induced in adult male Wistar rats by intraperitoneal injection of streptozotocin (STZ)...
July 15, 2016: Brain Research
https://www.readbyqxmd.com/read/27072640/polymer-induced-central-nervous-system-complications-following-vascular-procedures-spectrum-of-iatrogenic-injuries-and-review-of-outcomes
#15
Rashi I Mehta, Rupal I Mehta
Polymer substances are commonly applied as surface coatings on endovascular catheters and vascular devices. Adverse effects related to their use have been reported, although the overall clinical significance and appropriate methods of detection of these complications have been unclear. In this analysis, we systematically reviewed clinical and diagnostic features in 32 patients (age, 36-87years; mean, 59years) in whom intracranial polymer reactions were documented following vascular interventions. Associated neuroradiologic and neuropathologic findings were variable and included cerebral vasculitis or vasculopathy (63%), abscess or granuloma formation (38%), ischemic infarcts (28%), parenchymal hematomas (28%), white matter change (25%), and/or chemical meningitis (22%)...
July 2016: Human Pathology
https://www.readbyqxmd.com/read/27039043/progesterone-in-the-treatment-of-neonatal-arterial-ischemic-stroke-and-acute-seizures-role-of-bdnf-trkb-signaling
#16
Fahim Atif, Seema Yousuf, Donald G Stein
Neonatal stroke is among the top ten causes of childhood death and permanent disability in survivors, but no safe and effective acute treatments exist. To advance understanding of its neuroprotective mechanisms, we examined the effects of progesterone (PROG) on local and systemic inflammation (IL-1β, IL-6, TNFα), brain derived neurotrophic factor/Tropomyosin receptor kinase B (BDNF/TrkB) signaling, vascular damage (vascular endothelial growth factor (VEGF), matrix metalloproteinase-9 (MMP-9)), acute behavioral seizures and brain infarction size following neonatal arterial ischemic stroke in mice...
August 2016: Neuropharmacology
https://www.readbyqxmd.com/read/27019697/epileptogenesis-in-neurocutaneous-disorders-with-focus-in-sturge-weber-syndrome
#17
REVIEW
Anna Pinto, Mustafa Sahin, Phillip L Pearl
Epilepsy is a major morbidity in Sturge Weber syndrome, a segmental vascular neurocutaneous disorder classically associated with facial angiomas, glaucoma, and leptomeningeal capillary-venous type vascular malformations. The extent of the latter correlates with neurological outcome. Post-zygotic mosaicism for the activating mutation p.R183Q of the GNAQ gene has been identified as the major cause.  GNAQ encodes for an alpha subunit of a heterotrimeric G protein critical to blood vessel development. The earlier the timing of the mutation in development, the more severe the involvement, e...
2016: F1000Research
https://www.readbyqxmd.com/read/26961195/computed-tomography-perfusion-as-a-diagnostic-tool-for-seizures-after-ischemic-stroke
#18
Miriam Koome, Leonid Churilov, Ziyuan Chen, Ziyi Chen, Jillian Naylor, Arthur Thevathasan, Bernard Yan, Patrick Kwan
INTRODUCTION: Cerebral cortical ischemia is a risk factor for post-stroke seizures. However, the optimal imaging method is unclear. We investigated CT perfusion (CTP) in detecting cortical ischemia and its correlation with post-stroke seizures compared with non-contrast CT (NCCT). METHODS: We included patients with acute ischemic stroke admitted to the Royal Melbourne Hospital between 2009 and 2014. Post-stroke seizure information was collected. Cortical involvement was determined on acute NCCT and CTP (T max, cerebral blood volume [CBV], and cerebral blood flow [CBF])...
June 2016: Neuroradiology
https://www.readbyqxmd.com/read/26953551/-neurological-disorders-and-pregnancy
#19
P Berlit
Neurological disorders caused by pregnancy and puerperium include the posterior reversible encephalopathy syndrome, the amniotic fluid embolism syndrome (AFES), the postpartum angiopathy due to reversible vasoconstriction syndrome, and the Sheehan syndrome. Hypertension and proteinuria are the hallmarks of preeclampsia, seizures define eclampsia. Hemolysis, elevated liver enzymes and low platelets constitute the HELLP syndrome. Vision disturbances including cortical blindness occur in the posterior reversible encephalopathy syndrome (PRES)...
February 2016: Fortschritte der Neurologie-Psychiatrie
https://www.readbyqxmd.com/read/26919195/post-epilepsy-stroke-a-review
#20
Jing Jin, Rong Chen, Zheng Xiao
Stroke and epilepsy are two of the most common neurological disorders and share a complicated relationship. It is well established that stroke is one of the most important causes of epilepsy, particularly new-onset epilepsy among the elderly. However, post-epilepsy stroke has been overlooked. In recent years, it has been demonstrated that epilepsy patients have increased risk and mortality from stroke when compared with the general population. Additionally, it was proposed that post-epilepsy stroke might be associated with antiepileptic drugs (AEDs), epileptic seizures and the lifestyle of epileptic patients...
2016: Expert Review of Neurotherapeutics
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