keyword
https://read.qxmd.com/read/38436680/effectiveness-and-tolerability-of-brivaracetam-in-patients-with-epilepsy-stratified-by-comorbidities-and-etiology-in-the-real-world-12-month-subgroup-data-from-the-international-experience-pooled-analysis
#1
JOURNAL ARTICLE
Jerzy P Szaflarski, Hervé Besson, Wendyl D'Souza, Edward Faught, Pavel Klein, Markus Reuber, Felix Rosenow, Javier Salas-Puig, Victor Soto Insuga, Bernhard J Steinhoff, Adam Strzelczyk, Dimitrios Bourikas, Tony Daniels, Florin Floricel, David Friesen, Cédric Laloyaux, Vicente Villanueva
OBJECTIVE: To assess the effectiveness and tolerability of brivaracetam (BRV) in adults with epilepsy by specific comorbidities and epilepsy etiologies. METHODS: EXPERIENCE/EPD332 was a pooled analysis of individual patient records from several non-interventional studies of patients with epilepsy initiating BRV in clinical practice. Outcomes included ≥ 50% reduction from baseline in seizure frequency, seizure freedom (no seizures within prior 3 months), continuous seizure freedom (no seizures since baseline), BRV discontinuation, and treatment-emergent adverse events (TEAEs) at 3, 6, and 12 months...
March 4, 2024: Journal of Neurology
https://read.qxmd.com/read/38434369/efficacy-and-safety-of-perampanel-in-the-treatment-of-post-stroke-epilepsy-a-multicenter-real-world-study
#2
JOURNAL ARTICLE
Cuihua Yan, Tingting Yang, Yuanping Sun, Junji Hu, Xiangming Yi, Chunxiao Li, Juan Chen, Kunkun Wei, Jing Jiang, Qi Xiang, Anru Liu, Yuxiang Han, Liling Yang, Xiaoyun Liu, Tao Han, Xuewu Liu
BACKGROUND: Since 2019, Perampanel (PER) has been endorsed in China as an adjunctive treatment for focal seizures, both with and without impaired awareness, and for the transition from focal to bilateral tonic-clonic seizures. Limited research exists regarding the efficacy of PER in treating post-stroke epilepsy (PSE) in China. Empirical studies are essential to guide treatment protocols. We conducted a retrospective study to assess the efficacy and tolerability of PER in 58 PSE patients treated between October 2019 and July 2023...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38432120/outcomes-and-predictors-of-seizure-recurrence-in-post-stroke-epilepsy-a-retrospective-hospital-based-study
#3
JOURNAL ARTICLE
Erum Shariff, Saima Nazish, Rizwana Shahid, Azra Zafar, Zakia M Yasawy, Norah A AlKhaldi, Danah AlJaafari, Nehad M Soltan, Foziah Alshamrani, Mohammed AlShurem, Aishah Ibrahim Albakr, Feras AlSulaiman, Rana Alameri, Majed Alabdali
BACKGROUND: The occurrence of seizures following a stroke is a well-recognized complication associated with a significant increase in morbidity and mortality. Despite the numerous studies examining outcomes and risk factors related to post-stroke seizures (PSS), there remains a lack of clarity regarding the clinical characteristics, treatment, and PSS recurrence (PSSR) rates in patients experiencing their initial episode of PSS. PURPOSE: This study aimed to determine the risk factors for developing recurrent seizures after first PSS and their effects on functional outcomes and mortality...
February 27, 2024: Clinical Neurology and Neurosurgery
https://read.qxmd.com/read/38382475/the-role-of-neurohospitalism-in-a-specialized-cardiovascular-hospital
#4
JOURNAL ARTICLE
Miguel Serôdio, Marta Magriço, André Sobral-Pinho, Rita Ventura, Filipa Serrazina, Gonçalo Cabral, Bruna Meira, Marco Fernandes, Manuel Salavisa, Marlene Saraiva, João Pedro Marto, Francisca Sá, Sofia Calado, Miguel Viana Baptista
INTRODUCTION: Cardiology and cardiothoracic surgery are among the specialties that most commonly require neurology inpatient consultations. We aimed to study the neurology referrals by the cardiovascular-specialized hospital included in our tertiary hospital center. METHODS: Retrospective study of consecutive patients referred for neurology inpatient consultation between 01/01/2020 and 31/12/2022. We analyzed referrals, patients' characteristics, and the approach taken...
February 21, 2024: European Neurology
https://read.qxmd.com/read/38364334/neutrophil-to-lymphocyte-ratio-and-early-seizures-after-ischemic-stroke-a-case-control-study
#5
JOURNAL ARTICLE
Lea Ebner, Piergiorgio Lochner, Simona Lattanzi, Francesco Brigo, Gudrun Wagenpfeil, Klaus Faßbender, Frauke Röll
BACKGROUND: Early post-stroke seizures (EPSS) are associated with an increased risk of mortality and post-stroke epilepsy. This study aimed to identify potential risk factors for EPSS, focusing on blood parameters, such as the neutrophil-to-lymphocyte ratio (NLR), which is a biomarker for inflammation. METHODS: Patients treated for ischemic stroke between 2017 and 2019 were retrospectively identified. 44 of them had a first epileptic seizure within 7 days after the stroke...
March 2024: Epilepsy & Behavior: E&B
https://read.qxmd.com/read/38338726/high-doses-of-ana12-improve-phenobarbital-efficacy-in-a-model-of-neonatal-post-ischemic-seizures
#6
JOURNAL ARTICLE
Preeti Vyas, Ira Chaturvedi, Yun Hwang, Joseph Scafidi, Shilpa D Kadam, Carl E Stafstrom
Phenobarbital (PB) remains the first-line medication for neonatal seizures. Yet, seizures in many newborns, particularly those associated with perinatal ischemia, are resistant to PB. Previous animal studies have shown that in postnatal day P7 mice pups with ischemic stroke induced by unilateral carotid ligation, the tyrosine receptor kinase B (TrkB) antagonist ANA12 (N-[2-[[(hexahydro-2-oxo-1H-azepin-3-yl)amino]carbonyl]phenyl]-benzo[b]thiophene-2-carboxamide, 5 mg/kg) improved the efficacy of PB in reducing seizure occurrence...
January 24, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38321780/clinical-implications-of-various-electroencephalographic-patterns-in-post-stroke-seizures-the-utility-of-routine-electroencephalogram
#7
JOURNAL ARTICLE
Erum Shariff, Saima Nazish, Azra Zafar, Rizwana Shahid, Norah A AlKhaldi, Modhi Saad A Alkhaldi, Danah AlJaafari, Nehad M Soltan, Mohammed AlShurem, Aishah Ibrahim Albakr, Feras AlSulaiman, Majed Alabdali
Objective: Post-stroke seizures (PSS) are one of the major stroke-related complications. Early therapeutic interventions are critical therefore using electroencephalography (EEG) as a predictive tool for future recurrence may be helpful. We aimed to assess frequencies of different EEG patterns in patients with PSS and their association with seizure recurrence and functional outcomes. Methods: All patients admitted with PSS were included and underwent interictal EEG recording during their admission and monitored for seizure recurrence for 24 months...
February 6, 2024: Clinical EEG and Neuroscience: Official Journal of the EEG and Clinical Neuroscience Society (ENCS)
https://read.qxmd.com/read/38313653/electroencephalogram-findings-in-10-patients-with-post-stroke-epilepsy-a-retrospective-study
#8
JOURNAL ARTICLE
Li-Min Wen, Ran Li, Yan-Ling Wang, Qing-Xia Kong, Min Xia
BACKGROUND: Post-stroke epilepsy is a common and easily overlooked complication of acute cerebrovascular disease. Long-term seizures can seriously affect the prognosis and quality of life of patients. Electroencephalogram (EEG) is the simplest way to diagnose epilepsy, and plays an important role in predicting seizures and guiding medication. AIM: To explore the EEG characteristics of patients with post-stroke epilepsy and improve the detection rate of inter-seizure epileptiform discharges...
January 16, 2024: World Journal of Clinical Cases
https://read.qxmd.com/read/38312310/acute-cerebral-microbleeds-detected-on-high-resolution-head-ct-presenting-with-transient-neurologic-events
#9
Abdullah Tawakul, Arturo R Toro, José Rafael Romero
INTRODUCTION: Cerebral microbleeds (CMBs) are deposits of hemosiderin-laden macrophages that can be visualized on T2-weighted MRI sequences as small, ovoid areas of signal void. These markers represent hemorrhagic cerebral small vessel disease and are usually subclinical and asymptomatic. In these cases, we present two patients who presented with symptomatic, acute CMBs. CASE DESCRIPTION: Case 1 involves a 70-year-old male with history of diabetes, hypertension, hyperlipidemia, and obstructive sleep apnea...
2024: Cerebral circulation—cognition and behavior
https://read.qxmd.com/read/38296550/factors-associated-with-early-and-late-seizure-related-to-aneurysmal-subarachnoid-hemorrhage
#10
JOURNAL ARTICLE
Shota Nakashima, Hiroki Nishibayashi, Rie Yako, Masamichi Ishii, Naotsugu Toki, Masaki Tomobuchi, Toshihito Nakai, Hiromi Yamoto, Yoko Nakanishi, Naoyuki Nakao
Post-stroke epilepsy may occur after aneurysmal subarachnoid hemorrhage (aSAH). Both early and late seizures could cause severe neurocognitive deficits if administration of appropriate antiseizure medication is delayed. Therefore, it is important to elucidate the risk factors for early and late seizures, which could be shared with medical teams to promptly manage seizures. There are aspects of both hemorrhage and ischemia in aSAH, and thus, numerous risk factors are considered for early and late seizures. We examined factors associated with aSAH-related early and late seizures...
January 31, 2024: Neurologia Medico-chirurgica
https://read.qxmd.com/read/38281579/white-matter-hyperintensities-as-a-predictor-of-aphasia-recovery
#11
JOURNAL ARTICLE
Joseph S Kang, Lisa D Bunker, Melissa D Stockbridge, Argye E Hillis
OBJECTIVE: To examine the relationship between baseline white matter hyperintensities (WMH) and change in naming, content production, and efficiency following treatment in subacute aphasia. We hypothesized that more severe baseline WMH would result in less improvement with treatment. DESIGN: Retrospective analysis of a cohort from a double-blind randomized controlled trial (RCT). SETTING: Outpatient clinical setting or participant home. PARTICIPANTS: We retrospectively reviewed imaging and behavioral data for 52 participants with subacute aphasia due to left-hemisphere ischemic stroke enrolled in the RCT...
January 26, 2024: Archives of Physical Medicine and Rehabilitation
https://read.qxmd.com/read/38262944/contrast-induced-encephalopathy-after-an-embolization-procedure-for-a-cerebral-aneurysm-in-a-female-with-subarachnoid-hemorrhage-a-case-report
#12
JOURNAL ARTICLE
Jing Ren, Yinhua Ge, Ruyi Wen, Yong Zhang, Jun Shen, Wenjun Chen
BACKGROUND: Contrast-induced encephalopathy (CIE) is a rare complication during or after angiography, usually transient and reversible. CIE diagnosis is challenging due to the absence of no formal diagnostic criteria. CIE can mimic stroke symptoms, including visual disturbances, seizures, confusion, coma, and focal neurological deficits. This case reports neurological deficit reversal in a CIE patient due to the embolization of an intracranial aneurysm, the second angiographic procedure in six days...
January 23, 2024: BMC Neurology
https://read.qxmd.com/read/38255970/matrix-metalloproteinase-9-contributes-to-epilepsy-development-after-ischemic-stroke-in-mice
#13
JOURNAL ARTICLE
Barbara Pijet, Agnieszka Kostrzewska-Księzyk, Maja Pijet-Kucicka, Leszek Kaczmarek
Epilepsy, a neurological disorder affecting over 50 million individuals globally, is characterized by an enduring predisposition and diverse consequences, both neurobiological and social. Acquired epilepsy, constituting 30% of cases, often results from brain-damaging injuries like ischemic stroke. With one third of epilepsy cases being resistant to existing drugs and without any preventive therapeutics for epileptogenesis, identifying anti-epileptogenic targets is crucial. Stroke being a leading cause of acquired epilepsy, particularly in the elderly, prompts the need for understanding post-stroke epileptogenesis...
January 11, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38238638/brain-development-in-newborns-and-infants-after-ecmo
#14
REVIEW
Kai Yan, Lu-Kun Tang, Fei-Fan Xiao, Peng Zhang, Guo-Qiang Cheng, Lai-Shuan Wang, Chun-Mei Lu, Meng-Meng Ge, Li-Yuan Hu, Yuan-Feng Zhou, Tian-Tian Xiao, Yan Xu, Zhao-Qing Yin, Gang-Feng Yan, Guo-Ping Lu, Qi Li, Wen-Hao Zhou
BACKGROUND: Extracorporeal membrane oxygenation (ECMO) not only significantly improves survival rates in severely ill neonates but also is associated with long-term neurodevelopmental issues. To systematically review the available literature on the neurodevelopmental outcomes of neonates and infants who have undergone ECMO treatment, with a focus on motor deficits, cognitive impairments, sensory impairments, and developmental delays. This review aims to understand the incidence, prevalence, and risk factors for these problems and to explore current nursing care and management strategies...
January 19, 2024: World Journal of Pediatrics: WJP
https://read.qxmd.com/read/38170290/three-year-incidence-and-acute-setting-predictors-of-epilepsy-after-neonatal-and-childhood-arterial-ischaemic-stroke-a-disease-based-cohort-study
#15
JOURNAL ARTICLE
Mauricio Lopez-Espejo, Ilona Skorin, Tomas Mesa, Marta I Hernandez-Chavez
UNLABELLED: To assess the association between clinical and MRI characteristics of arterial ischaemic stroke (AIS) and the 3-year risk of post-stroke epilepsy (PSE) in paediatric patients. Retrospective cohort study. Database from a single tertiary referral centre for paediatric stroke in Chile. Two hundred seven neonates and children (1 day to 18 years) with a first-ever supratentorial AIS diagnosed between January 2003 and December 2019 were evaluated. Diagnosis of PSE and explanatory variables were consecutively recorded from hospital inpatient and annual outpatient records in a predesigned database...
January 3, 2024: European Journal of Pediatrics
https://read.qxmd.com/read/38159505/the-added-value-of-risk-assessment-and-subsequent-targeted-treatment-for-epileptic-seizures-after-stroke-an-early-hta-analysis
#16
JOURNAL ARTICLE
Elles P Elschot, Manuela A Joore, Rob P W Rouhl, Rob J Lamberts, Walter H Backes, Jacobus F A Jansen
INTRODUCTION: The development of post-stroke epilepsy (PSE) is related to a worse clinical outcome in stroke patients. Adding a biomarker to the clinical diagnostic process for the prediction of PSE may help to establish targeted and personalized treatment for high-risk patients, which could lead to improved patient outcomes. We assessed the added value of a risk assessment and subsequent targeted treatment by conducting an early Health Technology Assessment. METHODS: Interviews were conducted with four relevant stakeholders in the field of PSE to obtain a realistic view of the current healthcare and their opinions on the potential value of a PSE risk assessment and subsequent targeted treatment...
December 29, 2023: Epilepsy & Behavior: E&B
https://read.qxmd.com/read/38140999/-beating-heart-surgical-treatment-of-atrio-esophageal-fistula-after-radiofrequency-ablation-of-atrial-fibrillation
#17
JOURNAL ARTICLE
Davide Di Lazzaro, Romina Pantanella, Valeria Berti, Uberto Da Col
Atrio-esophageal fistula (AEF) is a rare (0.02-0.1%) complication of radiofrequency ablation for atrial fibrillation and is associated with high mortality. It typically presents between 2 and 6 weeks after catheter ablation. AEF was reported to be the second complication as cause of death after radiofrequency ablation with a mortality rate of 71%. Common clinical features of AEF include dysphagia, nausea, heartburn, hematemesis or melena, high fever, sepsis, pericardial or pleural effusions, mediastinitis, seizures, and stroke...
January 2024: Giornale Italiano di Cardiologia
https://read.qxmd.com/read/38134643/post-stroke-epilepsy-from-clinical-predictors-to-possible-mechanisms
#18
REVIEW
Sofia Freiman, W Allen Hauser, Flora Rider, Natalia Gulyaeva, Alla Guekht
BACKGROUND: Stroke is the most common cause of newly diagnosed epilepsy in the elderly, ahead of degenerative disorders, brain tumors, and head trauma. Stroke accounts for 30-50% of unprovoked seizures in patients aged ≥ 60 years. This review discusses the current understanding of epidemiology, risk factors, mechanisms, prevention, and treatment opportunities for post-stroke epilepsy (PSE). METHODS: We performed a literature search in the PubMed and Cochrane Library databases...
December 15, 2023: Epilepsy Research
https://read.qxmd.com/read/38107633/post-stroke-seizures-epilepsy-and-mortality-in-a-prospective-hospital-based-study
#19
JOURNAL ARTICLE
Sofia Freiman, W Allen Hauser, Flora Rider, Sofia Yaroslavskaya, Olga Sazina, Elena Vladimirova, Igor Kaimovsky, Alexander Shpak, Natalia Gulyaeva, Alla Guekht
BACKGROUND AND OBJECTIVES: Post-stroke epilepsy (PSE) is a significant concern in the elderly population, with stroke being a leading cause of epilepsy in this demographic. Several factors have shown consistent associations with the risk of developing PSE, including cortical lesions, initial stroke severity, younger age, and the occurrence of early seizures. The primary objectives of this study were two-fold: (1) to determine the incidence of PSE and (2) to identify the risk factors associated with PSE in a prospective cohort of post-stroke patients...
2023: Frontiers in Neurology
https://read.qxmd.com/read/38074155/efficacy-and-safety-of-chinese-herbal-medicine-in-post-stroke-epilepsy-a-systematic-review-and-meta-analysis
#20
Tianye Sun, Kaiyue Wang, Lili Li, Mingyuan Yan, Jing Wu, Jinmin Liu
Background: Poststroke epilepsy (PSE) is a common complication of strokes that seriously affects the recovery and quality of life of patients, and effective treatments are needed. Chinese herbal medicine (CHM) adjunctive therapy is a viable treatment option, but current evidence is insufficient to support its efficacy and safety. This study aimed to evaluate the efficacy and tolerability of CHM adjunctive therapy in the treatment of PSE. Methods: A systematic search of eight databases was conducted to identify PSE-related randomized clinical trials from the inception of each database through October 2023...
2023: Frontiers in Pharmacology
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