Zhenyou Zou, Fengyao Wu, Liguan Chen, Hua Yao, Zengxian Wang, Yongfeng Chen, Ming Qi, Yang Jiang, Longhua Tang, Xinying Gan, Lingjia Kong, Zhicheng Yang, Xiaolan Huang, Wei Shu, Bixue Li, Xinyu Tan, Liwen Huang, Shi Bai, Lijuan Wu, Jinping Mo, Huilin Hu, Huihua Liu, Ruyi Zou, Yuhua Wei
INTRODUCTION: With age and ATP decrease in the body, the transcription factors hypophosphorylation weakens the transcription of Slc40a1 and hinders the expression of the iron discharger ferroportin. This may lead to iron accumulation in the brain and the catalysis of free radicals that damage cerebral neurons and eventually lead to Alzheimer's disease (AD). OBJECTIVES: To prevent AD caused by brain iron excretion disorders and reveal the mechanism of J bs-5YP peptide restoring ferroportin...
March 23, 2024: Journal of Advanced Research