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https://www.readbyqxmd.com/read/28500860/interventions-for-preventing-silent-cerebral-infarcts-in-people-with-sickle-cell-disease
#1
REVIEW
Lise J Estcourt, Patricia M Fortin, Sally Hopewell, Marialena Trivella, Carolyn Doree, Miguel R Abboud
BACKGROUND: Sickle cell disease (SCD) is one of the commonest severe monogenic disorders in the world, due to the inheritance of two abnormal haemoglobin (beta globin) genes. SCD can cause severe pain, significant end-organ damage, pulmonary complications, and premature death. Silent cerebral infarcts are the commonest neurological complication in children and probably adults with SCD. Silent cerebral infarcts also affect academic performance, increase cognitive deficits and may lower intelligence quotient...
May 13, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28483179/-cannabis-a-cognitive-illusion
#2
Gonzalo Galván, Manuel Guerrero-Martelo, Francisco Vásquez De la Hoz
INTRODUCTION: The vision of cannabis as a soft drug is due to the low risk perception that young and old people have of the drug. This perception is based on erroneous beliefs that people have about the drug. OBJECTIVE: To compare the beliefs of cannabis use and consequences among adolescents with a lifetime prevalence of cannabis use and those without a lifetime prevalence of cannabis use. METHOD: Quantitative, descriptive and cross-sectional study with a probability sample of 156 high school students who completed an ad-hoc questionnaire that included sociodemographic data and 22 questions about the beliefs that young people had about cannabis use and its consequences...
April 2017: Revista Colombiana de Psiquiatría
https://www.readbyqxmd.com/read/28482566/a-biocompatible-and-magnetic-nanocarrier-with-a-safe-uv-initiated-docetaxel-release-and-cancer-secretion-removal-properties-increases-therapeutic-potential-for-skin-cancer
#3
Fei Kong, Xiao Huang, Danyang Yue, Jun Pan
Cancer is a leading fatal disease worldwide. To increase its therapeutic efficiency, more effective with less side effect and patient acceptable administration approach is expected. Moreover, modification of tumor microenvironment is proved to be operative recently. In this paper, a nanocarrier named LDEDDS was developed for intelligent tropical administration of skin cancer, along with removal of hydrophobic cancerous secretion to change tumor microenvironment. It was made by coating of amphipathic polymer P(BA-co-HBA) on docetaxel (TXT, a model hydrophobic anticancer drug) loaded Fe3O4@ZnO...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28476522/preliminary-study-of-neurodevelopmental-outcomes-and-parenting-stress-in-pediatric-mitochondrial-disease
#4
Soyong Eom, Young-Mock Lee
BACKGROUND: Little is known regarding the neuropsychological profiles of pediatric patients with mitochondrial diseases or their parents, information that is crucial for improving the quality of life (QOL) for both patients and parents. We aimed to delineate neurodevelopment and psychological comorbidity in children with mitochondrial diseases in the preliminary investigation of adequate intervention methods, better prognoses, and improved QOL for both patients and parents. METHODS: Seventy children diagnosed with mitochondrial diseases were neuropsychologically evaluated...
February 2, 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/28458067/effect-of-liberal-blood-transfusion-on-clinical-outcomes-and-cost-in-spine-surgery-patients
#5
Taylor E Purvis, C Rory Goodwin, Rafael De la Garza-Ramos, A Karim Ahmed, Virginie Lafage, Brian J Neuman, Peter G Passias, Khaled M Kebaish, Steven M Frank, Daniel M Sciubba
BACKGROUND CONTEXT: Blood transfusions in spine surgery are shown to be associated with increased patient morbidity. The association between transfusion performed using a liberal hemoglobin (Hb) trigger-defined as an intraoperative Hb level of ≥10 g/dL, a postoperative level of ≥8 g/dL, or a whole hospital nadir between 8 and 10 g/dL-and perioperative morbidity and cost in spine surgery patients is unknown and thus was investigated in this study. PURPOSE: This study aimed to describe the perioperative outcomes and economic cost associated with liberal Hb trigger transfusion among spine surgery patients...
April 27, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28455134/cyclodextrin-nanosystems-in-oral-drug-delivery-a-mini-review
#6
Oluwatomide Adeoye, Helena Cabral-Marques
Oral delivery of many therapeutic agents remains challenging due to gastric insolubility/poor dissolution, inefficient intestinal permeability and pre-systemic inactivation. These problems limit the advantages of convenience and increased compliance they provide in the therapy of many chronic diseases. Cyclodextrin nanosystems have emerged as promising platforms for drug-specific construction of the oral delivery nanosystems able to optimize the desired physicochemical properties and pharmacokinetic parameters; without a compromise on safety...
April 26, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28443354/optimization-of-intelligent-infusion-pump-technology-to-minimize-vasopressor-pump-programming-errors
#7
Nina Vadiei, Carrie A Shuman, Manasa S Murthy, Mitchell J Daley
STUDY OBJECTIVE: To determine if incorporation of vasopressor upper hard limits (UHL) into intelligent infusion pump technology (IIPT) increases efficacy of alerts by preventing pump programming errors. DESIGN & METHODS: Retrospective review from five hospitals within a single healthcare network between April 1, 2013 and May 31, 2014. A total of 65,680 vasopressor data entries were evaluated; 19,377 prior to hard limit implementation and 46,303 after hard limit implementation...
April 26, 2017: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/28416021/effects-of-gabab-receptors-in-the-insula-on-recognition-memory-observed-with-intellicage
#8
Nan Wu, Feng Wang, Zhe Jin, Zhen Zhang, Lian-Kun Wang, Chun Zhang, Tao Sun
BACKGROUND: Insular function has gradually become a topic of intense study in cognitive research. Recognition memory is a commonly studied type of memory in memory research. GABABR has been shown to be closely related to memory formation. In the present study, we used intellicage, which is a new intelligent behavioural test system, and a bilateral drug microinjection technique to inject into the bilateral insula, to examine the relationship between GABABR and recognition memory. METHODS: Male Sprague-Dawley rats were randomly divided into control, Sham, Nacl, baclofen and CGP35348 groups...
April 17, 2017: Behavioral and Brain Functions: BBF
https://www.readbyqxmd.com/read/28411503/anatomical-distance-affects-cortical-subcortical-connectivity-in-first-episode-drug-naive-somatization-disorder
#9
Wenbin Guo, Feng Liu, Jindong Chen, Renrong Wu, Lehua Li, Zhikun Zhang, Huafu Chen, Jingping Zhao
BACKGROUND: Brain structural and functional alterations in the cortical-subcortical circuits have been observed in somatization disorder (SD). However, whether and how anatomical distance affects the cortical-subcortical connectivity in SD remain unclear. This study aims to examine whether anatomical distance affects the cortical-subcortical in first-episode, drug-naive SD. METHODS: Twenty-five first-episode, drug-naive patients with SD and twenty-eight healthy controls were recruited for a resting-state scan...
April 8, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28394234/s100%C3%AE-is-associated-with-cognitive-impairment-in-childhood-onset-systemic-lupus-erythematosus-patients
#10
A T Lapa, M Postal, N A Sinicato, B S Bellini, P T Fernandes, R Marini, S Appenzeller
Objective To investigate serologic S100β protein levels in childhood-onset SLE patients (cSLE) and to elucidate their association with disease activity and neuropsychiatric (NP) manifestations. Methods We included 71 cSLE patients (67 females; median age 18 years; range 9-37 and 53 (47 females; median age of 20 years; range 6-29) age and sex matched healthy controls. Neurological manifestations were analysed according to the American College of Rheumatology (ACR) criteria. Cognitive evaluation was performed in all participants using Wechsler Intelligence Scale for Children (WISC-III) and Wechsler Adult Intelligence Scale (WAIS), according to age, and validated in Portuguese...
April 2017: Lupus
https://www.readbyqxmd.com/read/28386037/using-artificial-intelligence-to-reduce-the-risk-of-nonadherence-in-patients-on-anticoagulation-therapy
#11
Daniel L Labovitz, Laura Shafner, Morayma Reyes Gil, Deepti Virmani, Adam Hanina
BACKGROUND AND PURPOSE: This study evaluated the use of an artificial intelligence platform on mobile devices in measuring and increasing medication adherence in stroke patients on anticoagulation therapy. The introduction of direct oral anticoagulants, while reducing the need for monitoring, have also placed pressure on patients to self-manage. Suboptimal adherence goes undetected as routine laboratory tests are not reliable indicators of adherence, placing patients at increased risk of stroke and bleeding...
May 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28315449/prophylactic-levetiracetam-for-seizure-control-after-cranioplasty-a-multicenter-prospective-controlled-study
#12
Shuli Liang, Ping Ding, Shaohui Zhang, Junchen Zhang, Jiwu Zhang, Yuping Wu
PURPOSE: To study the efficacy and safety of prophylactic levetiracetam (LEV) administration in adults undergoing cranioplasty. METHODS: Two hundred adults undergoing cranioplasty were prospectively enrolled and randomly divided into LEV group (prophylactic LEV for 24 weeks) and control group (no prophylactic anti-epileptic drugs). The patients' demographic and clinical characteristics, occurrence of postoperative seizure, changes in intelligence quotient (IQ), memory quotient (MQ), and activities of daily living (ADL) scores, as well as postoperative hospital stay side effects, were all analyzed at 2-, 24-, and 48-week follow-up visits...
March 14, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28223265/use-of-a-novel-artificial-intelligence-platform-on-mobile-devices-to-assess-dosing-compliance-in-a-phase-2-clinical-trial-in-subjects-with-schizophrenia
#13
Earle E Bain, Laura Shafner, David P Walling, Ahmed A Othman, Christy Chuang-Stein, John Hinkle, Adam Hanina
BACKGROUND: Accurately monitoring and collecting drug adherence data can allow for better understanding and interpretation of the outcomes of clinical trials. Most clinical trials use a combination of pill counts and self-reported data to measure drug adherence, despite the drawbacks of relying on these types of indirect measures. It is assumed that doses are taken, but the exact timing of these events is often incomplete and imprecise. OBJECTIVE: The objective of this pilot study was to evaluate the use of a novel artificial intelligence (AI) platform (AiCure) on mobile devices for measuring medication adherence, compared with modified directly observed therapy (mDOT) in a substudy of a Phase 2 trial of the α7 nicotinic receptor agonist (ABT-126) in subjects with schizophrenia...
February 21, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28221040/magnetic-fullerene-dna-hyaluronic-acid-nanovehicles-with-magnetism-reduction-dual-responsive-triggered-release
#14
Ling Wang, Yitong Wang, Jingcheng Hao, Shuli Dong
We created the dual-responsive nanovehicle that can effectively combine and abundantly utilize magnetic and glutathione (GSH)-reductive triggers to control the drug delivery and achieve more intelligent and powerful targeting. In the nanovehicles, paramagnetic fullerene (C60@CTAF) was prepared via one-step modification of fullerene with magnetic surfactant CTAF by hydrophobic interaction for the first time. The perfect conjugation of C60 and CTAF increased the solubility or dispersity of fullerenes and qualified CTAF with more powerful assembly capability with DNA...
March 13, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28212902/intrauterine-valproate-exposure-is-associated-with-alterations-in-hippocampal-cell-numbers-and-folate-metabolism-in-a-rat-model-of-valproate-teratogenicity
#15
Alexander Semmler, Christian Frisch, Christiane Bleul, Desiree Smith, Laurent Bigler, Jean-Christophe Prost, Henk Blom, Michael Linnebank
PURPOSE: Valproate is one of the most commonly used anticonvulsive drugs. Despite its significant benefits, the teratogenicity of valproate is a relevant problem in the treatment of women of childbearing age. In addition to major congenital malformations, such as neural tube defects, reduced intelligence and attention after intrauterine valproate exposure are reported. Until now the mechanisms of teratogenicity of VPA are poorly understood and concepts how to reduce valproate teratogenicity are lacking...
March 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28115259/biocompatible-polymersomes-based-cancer-theranostics-towards-multifunctional-nanomedicine
#16
REVIEW
Marzieh Mohammadi, Mohammad Ramezani, Khalil Abnous, Mona Alibolandi
Polymersomes are polymeric vesicles that have numerous advantages for theranostics, the integrated approach of therapeutics and diagnostics. Polymersomes possess core- shell structures which encapsulate hydrophilic molecules in the aqueous compartment and hydrophobic molecules in the bilayer of the vesicles. Polymersomes are made of different amphiphilic block copolymers. Thus, in the process of designing polymersomes, a variety of amphiphilic block copolymers with different molecular weights are used to develop intelligent or sustained released formulations and to modify the stability of the system and bilayer thickness or to functionalize the particle with targeting moieties to improve the delivery efficiency...
March 15, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28099806/melting-behavior-of-zipper-structured-lipopeptides-in-lipid-bilayer
#17
Sijia Wang, Xia Han, Danyang Liu, Mengya Li, Shouhong Xu, Honglai Liu
A zipper-structured lipopeptide is expected to play a role of "intelligent valve" in the lipid bilayer. In this paper, a series of zipper-structured lipopeptides have been designed for preparing thermocontrollable hybrid liposomes. Their conformational transition as a function of temperature in lipid bilayer has been investigated for understanding the influences of molecular structure and bilayer property on biofunction. The melting temperatures Tm of the lipopeptides have been found to depend on their molecular structures...
January 31, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28093297/bottom-up-synthesis-of-carbon-nanoparticles-with-higher-doxorubicin-efficacy
#18
Samer Bayda, Mohamad Hadla, Stefano Palazzolo, Vinit Kumar, Isabella Caligiuri, Emmanuele Ambrosi, Enrico Pontoglio, Marco Agostini, Tiziano Tuccinardi, Alvise Benedetti, Pietro Riello, Vincenzo Canzonieri, Giuseppe Corona, Giuseppe Toffoli, Flavio Rizzolio
Nanomedicine requires intelligent and non-toxic nanomaterials for real clinical applications. Carbon materials possess interesting properties but with some limitations due to toxic effects. Interest in carbon nanoparticles (CNPs) is increasing because they are considered green materials with tunable optical properties, overcoming the problem of toxicity associated with quantum dots or nanocrystals, and can be utilized as smart drug delivery systems. Using black tea as a raw material, we synthesized CNPs with a narrow size distribution, tunable optical properties covering visible to deep red absorption, non-toxicity and easy synthesis for large-scale production...
January 14, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28064050/development-of-a-novel-ph-sensitive-silane-crosslinked-injectable-hydrogel-for-controlled-release-of-neomycin-sulfate
#19
Sehrish Jabeen, Atif Islam, Abdul Ghaffar, Nafisa Gull, Ayesha Hameed, Anbreen Bashir, Tahir Jamil, Tousif Hussain
Silane crosslinked biopolymer based novel pH-responsive hydrogels were fabricated by blending the cationic (chitosan) and anionic (alginate) polymers with poly(vinyl alcohol). Tetraethoxysilane (TEOS) was used, as a crosslinker in different amounts due to its nonhazardous nature, to study its impact on physical and chemical properties of the prepared injectable hydrogels along with the controlled release of drug. The swelling response of the prepared hydrogels was examined in different solvent media which exhibited decreased swelling ratio with increase in the amount of TEOS...
April 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28057607/the-value-of-electronic-medical-record-implementation-in-mental-health-care-a-case-study
#20
Sanaz Riahi, Ilan Fischler, Melanie I Stuckey, Philip E Klassen, John Chen
BACKGROUND: Electronic medical records (EMR) have been implemented in many organizations to improve the quality of care. Evidence supporting the value added to a recovery-oriented mental health facility is lacking. OBJECTIVE: The goal of this project was to implement and customize a fully integrated EMR system in a specialized, recovery-oriented mental health care facility. This evaluation examined the outcomes of quality improvement initiatives driven by the EMR to determine the value that the EMR brought to the organization...
January 5, 2017: JMIR Medical Informatics
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