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https://www.readbyqxmd.com/read/29341027/developing-deep-learning-applications-for-life-science-and-pharma-industry
#1
Daniel Siegismund, Vasily Tolkachev, Stephan Heyse, Beate Sick, Oliver Duerr, Stephan Steigele
Deep Learning has boosted artificial intelligence over the past 5 years and is seen now as one of the major technological innovation areas, predicted to replace lots of repetitive, but complex tasks of human labor within the next decade. It is also expected to be 'game changing' for research activities in pharma and life sciences, where large sets of similar yet complex data samples are systematically analyzed. Deep learning is currently conquering formerly expert domains especially in areas requiring perception, previously not amenable to standard machine learning...
January 16, 2018: Drug Research
https://www.readbyqxmd.com/read/29337263/imem-2lsaac-a-two-level-model-for-discrimination-of-membrane-proteins-and-their-types-by-extending-the-notion-of-saac-into-chou-s-pseudo-amino-acid-composition
#2
Muhammad Arif, Maqsood Hayat, Zahoor Jan
Membrane proteins execute significant roles in cellular processes of living organisms, ranging from cell signaling to cell adhesion. As a major part of a cell, the identification of membrane proteins and their functional types become a challenging job in the field of bioinformatics and proteomics from last few decades. Traditional experimental procedures are slightly applicable due to lack of recognized structures, enormous time and space. In this regard, the demand for fast, accurate and intelligent computational method is increased day by day...
January 11, 2018: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29336897/the-real-world-effect-of-intravitreous-anti-vascular-endothelial-growth-factor-drugs-on-intraocular-pressure-an-analysis-using-the-iris-registry
#3
Elizabeth A Atchison, Kevin M Wood, Cynthia G Mattox, Catherine N Barry, Flora Lum, Mathew W MacCumber
PURPOSE: To identify sustained differences in intraocular pressure (IOP) after intravitreous injections of anti-vascular endothelial growth factor (VEGF) drugs. DESIGN: Database study. PARTICIPANTS: Patients seeing an ophthalmic provider who contributes to the database. METHODS: We identified a total of 23 776 unique patients who received only a single type of anti-VEGF medication (bevacizumab, aflibercept, or ranibizumab) by injection in the right eye in the American Academy of Ophthalmology Intelligent Research in Sight Registry...
January 11, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29324970/watson-for-oncology-and-breast-cancer-treatment-recommendations-agreement-with-an-expert-multidisciplinary-tumor-board
#4
S P Somashekhar, M-J Sepúlveda, S Puglielli, A D Norden, E H Shortliffe, C Rohit Kumar, A Rauthan, N Arun Kumar, P Patil, K Rhee, Y Ramya
Background: Breast cancer oncologists are challenged to personalize care with rapidly changing scientific evidence, drug approvals, and treatment guidelines. Artificial intelligence (AI) clinical decision-support systems (CDSSs) have the potential to help address this challenge. We report here the results of examining the level of agreement (concordance) between treatment recommendations made by the AI CDSS Watson for Oncology (WFO) and a multidisciplinary tumor board for breast cancer...
January 9, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29314634/advanced-inorganic-nanosystems-for-skin-drug-delivery
#5
REVIEW
E Carazo, A Borrego-Sánchez, F García-Villén, R Sánchez-Espejo, P Cerezo, C Aguzzi, C Viseras
On/into/through the skin drug delivery represents an attractive alternative for the oral route, providing local and/or systemic drug delivery. Due to its complex and well-organised structure, most of the drugs show difficulties to penetrate the human skin. Therefore, enormous efforts have been invested to develop intelligent drug delivery systems overcoming the skin barrier with particular emphasis on increasing therapeutic activity and minimizing undesirable side-effects. Most of these strategies require the use of singular materials with new properties...
January 5, 2018: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/29288733/ophthalmic-gels-past-present-and-future
#6
Ali A Al-Kinani, Ghada Zidan, Naba Elsaid, Ali Seyfoddin, Adam W G Alani, Raid G Alany
Aqueous gels formulated using hydrophilic polymers (hydrogels) along with those based on stimuli responsive polymers (in situ gelling or gel forming systems) continue to attract increasing interest for various eye health-related applications. They allow the incorporation of a variety of ophthalmic pharmaceuticals to achieve sustained and therapeutic levels of drugs and bioactives at target ocular sites. The integration of sophisticated drug delivery technologies such as nanotechnology-based, intelligent and environment responsive systems can extend current treatment duration to provide more clinically relevant time courses (weeks and months instead of hours and days) which will inevitably reduce dose frequency, increase patient compliance and improve clinical outcomes...
December 27, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29249247/-what-s-new-in-instrumental-dermatology
#7
V Chaussade
This "What's new in instrumental dermatology" dedicated skin surgeryis based upon a 2015-2017 literature analysis. The excision of skin cancers is an important part of surgical dermatology. Will artificial intelligence and new drug be able to face the increasing need for therapy? Wrong-site surgery is due to multiple factors. Photographs of biopsy site and short time between biopsy and surgery decrease postponement of surgery and wrong-site surgery. Noninvasive imaging technologies are improving and help to delineate skin tumors and increase the probability of complete tumor removal...
December 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29241087/development-of-a-fast-hplc-dad-method-for-simultaneous-quantitation-of-three-immunosuppressant-drugs-in-whole-blood-samples-using-intelligent-chemometrics-resolving-of-coeluting-peaks-in-the-presence-of-blood-interferences
#8
Maryam Vosough, Sadaf Mosleh Tehrani
The present study describes a fast high performance liquid chromatography-diode array detection analytical methodology for quantification of tacrolimus, everolimus and cyclosporine A in whole blood samples, with minimum sample preparation steps. A short isocratic chromatographic elution was coupled with second-order calibration using multivariate curve resolution to stablish a smart and green methodology. Due to presence of matrix effect, a sample-added calibration strategy was used for quantification purposes...
December 9, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29222076/adverse-drug-event-discovery-using-biomedical-literature-a-big-data-neural-network-adventure
#9
Ahmad P Tafti, Jonathan Badger, Eric LaRose, Ehsan Shirzadi, Andrea Mahnke, John Mayer, Zhan Ye, David Page, Peggy Peissig
BACKGROUND: The study of adverse drug events (ADEs) is a tenured topic in medical literature. In recent years, increasing numbers of scientific articles and health-related social media posts have been generated and shared daily, albeit with very limited use for ADE study and with little known about the content with respect to ADEs. OBJECTIVE: The aim of this study was to develop a big data analytics strategy that mines the content of scientific articles and health-related Web-based social media to detect and identify ADEs...
December 8, 2017: JMIR Medical Informatics
https://www.readbyqxmd.com/read/29163329/dystonic-dysarthria-in-wilson-disease-efficacy-of-zolpidem
#10
Aurélia Poujois, Michaela Pernon, Jean-Marc Trocello, France Woimant
Wilson disease (WD) is a rare genetic disorder characterized by copper overload in the liver and the brain. Neurological presentations are mainly related to the accumulation of copper in the basal ganglia, the brainstem, and the cerebellum. Dysarthria is a frequent symptom, with dystonic, spastic, or parkinsonian components and is usually resistant to medical or voice rehabilitation therapies. Here, we report the case of a patient with WD diagnosed at the age of 12, who presented a severe and constant dysarthria from dystonic origin which was unresponsive to benzodiazepines and anticholinergic drugs...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29161389/innovations-in-management-of-cardiac-disease-drugs-treatment-strategies-and-technology
#11
P Foëx
Within the last generation, the management of patients with heart disease has been transformed by advances in drug treatments, interventions and diagnostic technologies. The management of arterial hypertension saw beta-blockers demoted from first- to third-line treatment. Recent studies suggest that the goal of treatment may have to change to lower systolic blood pressures to prevent long-term organ damage. Today less than 15% of coronary revascularizations are surgical and more than 85% are done by interventional cardiologists inserting coronary stents...
December 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29159144/thermoresponsive-graphene-oxide-starch-micro-nanohydrogel-composite-as-biocompatible-drug-delivery-system
#12
Mina Sattari, Marziyeh Fathi, Mansour Daei, Hamid Erfan-Niya, Jaleh Barar, Ali Akbar Entezami
Introduction: Stimuli-responsive hydrogels, which indicate a significant response to the environmental change (e.g., pH, temperature, light, …), have potential applications for tissue engineering, drug delivery systems, cell therapy, artificial muscles, biosensors, etc. Among the temperature-responsive materials, poly (N-isopropylacrylamide) (PNIPAAm) based hydrogels have been widely developed and their properties can be easily tailored by manipulating the properties of the hydrogel and the composite material...
2017: BioImpacts: BI
https://www.readbyqxmd.com/read/29154040/multifunctional-protein-microparticles-for-medical-applications
#13
Hironori Yamazoe
Micro- and nano-scale intelligent devices can revolutionize the medical field. Although proteins are promising materials for creating biocompatible miniature medical devices with biological functions, construction of complicated solid-state architectures, using inherently vulnerable proteins, remains challenging. Here, I present a sophisticated strategy for constructing a multifunctional microparticle for medical applications using multiple proteins; this strategy achieved the retention of function, increased stability, and orientation control of the proteins in the fabricated particle...
October 31, 2017: Biomaterials
https://www.readbyqxmd.com/read/29107202/defining-the-phenotype-of-young-adults-with-family-histories-of-alcohol-and-other-substance-use-disorders-studies-from-the-family-health-patterns-project
#14
Ashley Acheson, Andrea S Vincent, Andrew J Cohoon, William R Lovallo
Individuals with a family history of alcohol and other drug use disorders (FH+) are at increased risk for developing substance use disorders themselves relative to those with no such histories (FH-). Here we sought to identify key characteristics associated with FH+ status and alcohol and other drug use disorder status in a large cohort of FH+ and FH- young adults. We conducted principal component analyses on demographic, temperament, and cognitive measures differentiating 506 FH+ and 528 FH- young adults. Three principal components were identified, and these component scores were then used to predict the odds of being FH+ and the odds of having an alcohol or other drug use disorder...
October 20, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/29102702/active-intestinal-drug-absorption-and-the-solubility-permeability-interplay
#15
Daniel Porat, Arik Dahan
The solubility-permeability interplay deals with the question: what is the concomitant effect on the drug's apparent permeability when increasing the apparent solubility with a solubility-enabling formulation? The solubility and the permeability are closely related, exhibit certain interplay between them, and ongoing research throughout the past decade shows that treating the one irrespectively of the other may be insufficient. The aim of this article is to provide an overview of the current knowledge on the solubility-permeability interplay when using solubility-enabling formulations for oral lipophilic drugs, highlighting active permeability aspects...
November 1, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29062918/amr-surveillance-in-low-and-middle-income-settings-a-roadmap-for-participation-in-the-global-antimicrobial-surveillance-system-glass
#16
Anna C Seale, N Claire Gordon, Jasmin Islam, Sharon J Peacock, J Anthony G Scott
Drug-resistant infections caused by bacteria with increasing antimicrobial resistance (AMR) threaten our ability to treat life-threatening conditions. Tackling AMR requires international collaboration and partnership. An early and leading priority to do this is to strengthen AMR surveillance, particularly in low-income countries where the burden of infectious diseases is highest and where data are most limited. The World Health Organization (WHO) has developed the Global AMR Surveillance System (GLASS) as one of a number of measures designed to tackle the problem of AMR, and WHO member states have been encouraged to produce National Action Plans for AMR by 2017...
2017: Wellcome Open Research
https://www.readbyqxmd.com/read/28886480/intelligent-visual-localization-of-wireless-capsule-endoscopes-enhanced-by-color-information
#17
George Dimas, Evaggelos Spyrou, Dimitris K Iakovidis, Anastasios Koulaouzidis
Wireless capsule endoscopy (WCE) is performed with a miniature swallowable endoscope enabling the visualization of the whole gastrointestinal (GI) tract. One of the most challenging problems in WCE is the localization of the capsule endoscope (CE) within the GI lumen. Contemporary, radiation-free localization approaches are mainly based on the use of external sensors and transit time estimation techniques, with practically low localization accuracy. Latest advances for the solution of this problem include localization approaches based solely on visual information from the CE camera...
September 1, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28846487/development-of-an-intelligent-spacer-data-logger-system
#18
Chris O'Callaghan, Nicholas J Smith, Peter W Barry, John Denyer
BACKGROUND: Although delivery of drugs from pressurized metered dose inhalers (pMDIs) via spacer devices is widespread it cannot be assumed that patients take their medication as prescribed or use their spacer appropriately. We developed a Spacer Data Logger device to record patient adherence and whether patients had shaken the pMDI, actuated it soon after shaking, and inhaled a sufficient volume from it. METHODS: We report an assessment of the Spacer Data Logger to measure and record that the pMDI was adequately shaken, the time to actuation, and the volume "inhaled" from the spacer up to 26 seconds after actuation...
August 28, 2017: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/28844172/hierarchical-pulmonary-target-nanoparticles-via-inhaled-administration-for-anticancer-drug-delivery
#19
Rui Chen, Liu Xu, Qin Fan, Man Li, Jingjing Wang, Li Wu, Weidong Li, Jinao Duan, Zhipeng Chen
Inhalation administration, compared with intravenous administration, significantly enhances chemotherapeutic drug exposure to the lung tissue and may increase the therapeutic effect for pulmonary anticancer. However, further identification of cancer cells after lung deposition of inhaled drugs is necessary to avoid side effects on normal lung tissue and to maximize drug efficacy. Moreover, as the action site of the major drug was intracellular organelles, drug target to the specific organelle is the final key for accurate drug delivery...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28806660/fluorescent-carbon-dot-gated-hollow-mesoporous-carbon-for-chemo-photothermal-synergistic-therapy
#20
Xiudan Wang, Yuanzhe Lin, Xian Li, Da Wang, Donghua Di, Qinfu Zhao, Siling Wang
An efficient and intelligent nano-carrier that combines cell imaging with near infrared (NIR) light and redox dual-responsive drug delivery was successfully prepared. The hollow mesoporous carbon (HMC) nanoparticles with high photothermal conversion ability were developed to increase the drug loading efficiency and realize chemotherapy and photothermal synergetic therapy. The photo-stable and luminescent carbon dots (CDs) were prepared from branched polyethyleneimine (PEI) by hydrothermal reaction. The PEI CDs (CDPEI) were grafted on the openings of HMC as the "gatekeepers" via disulfide units (HMC-SS-CDPEI) to prevent the premature release of doxorubicin (DOX)...
August 4, 2017: Journal of Colloid and Interface Science
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