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https://www.readbyqxmd.com/read/29668149/-chronic-low-back-pain-from-the-uncertain-medical-diagnosis-to-the-profane-etiologies
#1
Josiane Mbarga, Claude Pichonnaz, Rose-Anna Foley, Céline Ancey
This qualitative research article is based on interviews with 20 participants to a low back pain rehabilitation program in a Swiss hospital. It shows that, in the absence of the obvious cause that can explain pain, patients construct their own interpretations and explanations in order to give meaning to their experience. Their explanatory models mainly include the lifestyle and the physical aspects related to the body function, what leaves little room for the psychosocial component. Their interpretation is consequently discordant with the current medical approach, which considers that chronic low back pain results from bio-psycho-social factors...
April 18, 2018: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29668143/-care-for-unaccompanied-minor-migrant-adolescents-at-the-youth-health-consultation-support-psychotherapy-and-resilience
#2
Cédric Devillé, Nelle Lambert
The Unité Santé Jeunes of the Geneva University Hospitals offers multidisciplinary care to young people between the ages of 12 years and 25 years, including unaccompanied minor migrant adolescents. The psychiatrist and child psychiatrist of the unit participate actively. These young people are primarily teenagers, but it is clear from our experience that their care has some specificities and require an adaptation of the framework. The aim of this article is to open the reflection on socio-legal-educational support and the care to offer them to help them feeling secure and a different psychotherapeutic space...
April 18, 2018: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29668126/an-unconventional-polymerization-route-to-hydrophilic-fluorescent-organic-nanoparticles-for-multicolor-cellular-bioimaging
#3
Qingfu Ban, Jie Kong, Yinglai Hou, Jianxin Chen, Wen Sun, Xiaofei Zhang, Si Wu
We demonstrated an unconventional polymerization route to synthesize hydrophilic fluorescent organic nanoparticles (FONs) for multicolor cellular bioimaging in this contribution. Actually, it benefits from our unexpected discovery of a rapid polymerization reaction between 1, 6-hexanediol dipropiolate and 2, 4, 6-triazide-1, 3, 5-triazine under the catalysis of N, N, N', N", N"-pentamethyldiethylenetriamine (PMDETA). Interestingly, the 2, 4, 6-triazide-1, 3, 5-triazine and PMDETA system can also induce rapid free radical polymerization at room temperature...
April 18, 2018: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/29668124/a-reduced-dose-of-fluconazole-as-primary-antifungal-prophylaxis-is-not-associated-with-increased-risk-of-invasive-fungal-infections-after-allogeneic-stem-cell-transplantation-from-a-hla-identical-sibling
#4
B Sarina, J Mariotti, S Bramanti, L Morabito, R Crocchiolo, A Rimondo, F Tordato, D Pocaterra, E Casari, Chiara De Philippis, C Carlo-Stella, A Santoro, L Castagna
BACKGROUND: Invasive fungal infections (IFI) represent a common side effect of allogeneic hematopoietic stem cell transplant (allo-SCT), resulting in increased non relapse mortality (NRM) and reduced overall survival (OS) rates. 75-days of Fluconazole 400 mg/day represents the standard primary antifungal prophylaxis (PAP) after allo-SCT, especially for low-risk transplants. However, the ideal dosage of fluconazole has never been tested. METHODS: Here we report the experience of our institution on 113 consecutive patients receiving an allo-SCT from a HLA identical sibling between 1999 and 2015, where PAP consisted of fluconazole 100 mg/day only during the pre-engraftment phase...
April 18, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29668120/cytomegalovirus-infection-in-living-donor-liver-transplant-recipients-significantly-impacts-the-early-post-transplant-outcome-a-single-center-experience
#5
Sanjay Kumar Yadav, Sanjiv Saigal, Narendra Singh Choudhary, Sujeet Saha, Jayant Kumar Sah, Neeraj Saraf, Naveen Kumar, Sanjay Goja, Amit Rastogi, Prashant Bhangui, A S Soin
BACKGROUND: Cytomegalovirus (CMV) is the most common viral infection in liver transplant recipients that influences the outcomes of liver transplantation. However, its impact on early outcomes following living donor liver transplantation (LDLT) is not fully defined in the Indian subcontinent. This study was done to assess the impact of CMV infection on early post-transplant outcomes in LDLT recipients. METHODS: Out of 272 LDLTs performed from January 2012 to April 2013, 151 recipients underwent CMV viral load analysis in plasma within 90 days post LDLT based on clinical suspicion...
April 18, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29668116/a-bis-triazacyclononane-tris-pyridyl-n9-azacryptand-beer-can-receptor-for-complexation-of-alkali-metal-and-lead-ii-cations
#6
Asha Brown, Thanthapatra Bunchuay, Christopher Crane, Nicholas White, Amber Thompson, Paul D Beer
A new bis-triazacyclononane tris-pyridyl N9-azacryptand ligand is synthesised via a convenient one-pot [2 + 3] condensation reaction between triazacyclononane and 2,6-bis(bromomethyl) pyridine in the presence of M2CO3 (M = Na, K). The proton, lithium, sodium, potassium and lead(II) complexes of the ligand are characterised in the solid state. A preliminary solution-phase competition experiment indicates that the cryptand ligand preferentially binds lead(II) in the presence of sodium, calcium, potassium and zinc cations in methanol solution...
April 18, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29668111/efficient-in-planta-gene-targeting-in-tomato-using-geminiviral-replicons-and-the-crispr-cas9-system
#7
Tal Dahan-Meir, Shdema Filler-Hayut, Cathy Melamed-Bessudo, Samuel Bocobza, Henryk Czosnek, Asaph Aharoni, Avraham A Levy
Current breeding relies mostly on random mutagenesis and recombination to generate novel genetic variation. However, targeted genome editing is becoming an increasingly important tool for precise plant breeding. Using the CRISPR-Cas system combined with the bean yellow dwarf virus rolling circle replicon we optimized a method for targeted mutagenesis and gene replacement in tomato. The carotenoid isomerase (CRTISO) and phytoene synthase 1 (PSY1) genes from the carotenoid biosynthesis pathway were chosen as targets due to their easily detectable change of phenotype...
April 18, 2018: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/29668075/a-comparison-of-debate-and-role-play-in-enhancing-critical-thinking-and-communication-skills-of-medical-students-during-problem-based-learning
#8
Rabia Latif, Sadaf Mumtaz, Rafia Mumtaz, Aamir Hussain
Debate and role play for learning critical thinking and communication skills are being increasingly used in various undergraduate medical schools worldwide. We aim to compare students' views about effectiveness of two teaching strategies; debate and role play to exercise critical thinking and communication skills during problem-based learning (PBL). This is a comparative, cross-sectional, and questionnaire-based study. Our subjects were second year undergraduate female medical students enrolled in Imam Abdulrahman Bin Faisal University (IAU), College of Medicine from September 2014-2016, divided into 10 small PBL groups (10-13 students/group/year)...
April 18, 2018: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/29668074/a-20-year-experience-with-nocardiosis-in-solid-organ-transplant-sot-recipients-in-the-southwestern-united-states-a-single-center-study
#9
Aneela Majeed, Norman Beatty, Ahmad Iftikhar, Adeela Mushtaq, Julia Fisher, Pryce Gaynor, Jeeyong C Kim, Jose Luis Marquez, Francisco E Mora, Anca Georgescu, Tirdad Zangeneh
BACKGROUND: Nocardiosis is a life-threatening opportunistic infection. Solid organ transplant (SOT) recipients are at higher risk (incidence 0.04% to 3.5%) of developing nocardiosis. Rate of nocardiosis in the Southwestern US may be high due to environmental factors. METHODS: We performed a retrospective review study on 54 SOT patients diagnosed with Nocardia between 1997 and 2016 at our center. To explore the association of various risk factors with both the development of disseminated disease and mortality, a series of Fisher's exact tests was used...
April 18, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29668061/ligand-tuneable-red-emitting-iridium-iii-complexes-for-efficient-triplet-triplet-annihilation-upconversion-performance
#10
Simon J Pope, Thomas Stonelake, Kaitlin Phillips, Simon Coles, Peter Horton, Shannon Keane, Emily Stokes, Ian Fallis, Joseph Beames, Jianzhang Zhao, Kepeng Chen, Yuqi Hou, Andrew Hallett, Sean O'Kell
A series of substituted 2-phenylquinoxaline ligands have been explored to finely tune the visible emission properties of a corresponding set of cationic, cyclometalated iridium(III) complexes. The electronic and redox properties of the complexes were investigated using experimental (including time-resolved luminescence and transient absorption spectroscopy) and theoretical methods. The complexes display absorption and phosphorescent emission in the visible region attributed to MLCT transitions. The different substitution patterns of the ligands induce variations in these parameters...
April 18, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29668050/long-term-outcome-of-selective-neurectomy-for-refractory-periocular-synkinesis
#11
Martinus M van Veen, Joseph R Dusseldorp, Tessa A Hadlock
OBJECTIVE: The objective of this study was to investigate the long-term effect and treatment stability of selective neurectomy for refractory periocular synkinesis. METHODS: We performed a retrospective review of all patients treated with highly selective neurectomy for refractory periocular synkinesis between August 2009 and August 2015. Primary outcome was time to recommencing treatment for periocular synkinesis. Palpebral fissure width was measured preoperatively, postoperatively, and at long-term ( > 2...
April 18, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29668039/medical-marijuana-use-in-older-adults
#12
Joshua Briscoe, David Casarett
Symptom management in older adults, including pain and distressing non-pain symptoms, can be challenging. Medications can cause side effects that worsen quality of life or create other symptoms, and polypharmacy itself can be detrimental in older adults. Cannabinoids may offer a way of managing selected symptoms with fewer side effects. Medical marijuana is an important area of study for older adults because of the side effects of other medications. It is also important for Baby Boomers, who are likely to have more experience with marijuana than older adults of previous generations...
April 18, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29668038/photodynamic-therapy-induces-antifibrotic-alterations-in-primary-human-vocal-fold-fibroblasts
#13
Chi Zhang, Jiajia Wang, Adriana Chou, Ting Gong, Erin E Devine, Jack J Jiang
OBJECTIVES/HYPOTHESIS: Photodynamic therapy (PDT) is a promising treatment modality for laryngeal dysplasia, early-stage carcinoma, and papilloma, and was reported to have the ability to preserve laryngeal function and voice quality without clinical fibrotic response. We aimed to investigate the mechanism behind the antifibrotic effects of PDT on primary human vocal fold fibroblasts (VFFs) in vitro. STUDY DESIGN: In vitro analysis from one human donor. METHODS: Cell viability of VFFs in response to varying doses of PDT was investigated by the Cell Counting Kit-8 method...
April 18, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29668020/adolescent-sexual-health-and-education-where-does-the-pediatrician-s-responsibility-fall
#14
Rachel S Dawson
Adolescence is a stressful time with a considerable amount of change, not only physically, with all the changes expected throughout puberty, but also emotionally, spiritually, and psychosocially. Teens are learning how to build and sustain relationships, learning boundaries in all areas of their lives, experimenting, as well as setting values that will sustain them throughout their lives. Home, school, various social settings, and places of worship all contribute to where adolescents learn what their values are, what they want their values to be, and how they start to make choices about their personal beliefs, which may not always align with their family values...
April 1, 2018: Pediatric Annals
https://www.readbyqxmd.com/read/29667998/isolation-purification-characterization-and-bioactivities-of-a-glucan-from-the-root-of-pueraria-lobata
#15
Can Xu, Ningbo Qin, Chunyan Yan, Shumei Wang
The root of Pueraria lobata is considered to be a medicinal and edible herb for the treatment of diabetes, and it has a long history of application in China. To explore the constituents responsible for the anti-hyperglycemic activities of P. lobata, a water-soluble polysaccharide (PL70-1-1) was isolated and purified by using a DEAE-Cellulose 52 anion exchange column and a Sephacryl S-100 gel filtration column. Its molecular weight (2584 Da) was determined by high performance gel permeation chromatography (HPGPC)...
April 18, 2018: Food & Function
https://www.readbyqxmd.com/read/29667935/one-step-synthesis-of-sno-hierarchical-architectures-under-room-temperature-and-their-photocatalytic-properties
#16
Wenxiu Liu, Lili Yin, Rui Zhang, Hailian Yang, Jing Ma, Wenbin Cao
3D hierarchical SnO architectures were synthesized via a one-step dissolution-precipitation route under room temperature using SnCl22H2O and Na2CO3 as initial reagents. The morphology and size of the prepared SnO structures could be easily tailored by alternating the solvent from deionized water with absolute ethanol. The SEM observation shows that the prepared 3D SnO hierarchical architectures were consisted of nanosheets. And the size of the SnO hierarchical architectures could be effectively reduced from 4 - 10 μm to 1 - 2 μm when the solvent was changed from water to ethanol while the thickness of the assembling nanosheets will be reduced from 200 - 500 nm to 20 - 30 nm at the same time...
April 18, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29667934/brain-computer-interaction-for-online-enhancement-of-visuospatial-attention-performance
#17
Romain Trachel, Thomas Brochier, Maureen Clerc
OBJECTIVE: the goal of this study is to investigate whether BCI that decode the location of covert attention can be leveraged to enhance visuospatial attention performance. Here, the covert attention task is to discriminate the orientation of a low-contrast target embedded in dynamic noise. Visuospatial attention performance is measured by the reaction time and the accuracy of target discrimination. APPROACH: The target location is indicated by a central cue made of randomly moving dots providing either predictive or ambiguous information...
April 18, 2018: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29667932/fused-data-transrectal-eit-for-prostate-cancer-imaging
#18
Ethan K Murphy, Xiaotian Wu, Ryan J Halter
OBJECTIVE: Prostate cancer is a significant problem affecting 1 in 7 men. Unfortunately, the diagnostic gold-standard of ultrasound-guided biopsy misses 10-30% of all cancers. The objective of this study was to develop an Electrical Impedance Tomography (EIT) approach that has the potential to image the entire prostate using multiple impedance measurements recorded between electrodes integrated onto an end-fired transrectal ultrasound (TRUS) device and a biopsy probe (BP). APPROACH: Simulations and sensitivity analyses were used to investigate the best combination of electrodes, and measured tank experiments were used to evaluate a fused-data transrectal EIT (fd-TREIT) and BP approach...
April 18, 2018: Physiological Measurement
https://www.readbyqxmd.com/read/29667923/autoethnography-and-cognitive-adaptation-two-powerful-buffers-against-the-negative-consequences-of-workplace-bullying-and-academic-mobbing
#19
Mpho M Pheko
Work is undoubtedly fundamental to human life, social development and the economic development of individuals, organizations and nations. However, the experience of working is not always pleasant as there are many instances where relationships between workers could deteriorate, leading to practices and behaviours that could be characterized as workplace bullying and/or mobbing. The current study is an exploratory study which used autoethnography to investigate experiences of academic bullying and mobbing, and relates the practices to power structures in academic institutions...
December 2018: International Journal of Qualitative Studies on Health and Well-being
https://www.readbyqxmd.com/read/29667920/child-life-services-in-an-epilepsy-monitoring-unit
#20
Daniel B Lowenstein, Mackenzie C Cervenka, Lauren Mitchell, Noelle Stewart, Eric H Kossoff, Sarah A Kelley
The goal of this study was to determine the value of a certified child life specialist (CCLS) on the patient and staff experiences in an epilepsy monitoring unit (EMU). We integrated a CCLS into the EMU for all children as well as adults with intellectual disability. We surveyed families to determine the impact of child life services on their stay. EMU staff completed questionnaires to determine perceived impact to their job performance from the integration of the CCLS. All of the families (pediatric and adult patients) who responded to the survey reported the presence of the CCLS improved their hospital experience...
April 1, 2018: Clinical Pediatrics
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