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https://www.readbyqxmd.com/read/28550818/blochsolver-a-gpu-optimized-fast-3d-mri-simulator-for-experimentally-compatible-pulse-sequences
#1
Ryoichi Kose, Katsumi Kose
A magnetic resonance imaging (MRI) simulator, which reproduces MRI experiments using computers, has been developed using two graphic-processor-unit (GPU) boards (GTX 1080). The MRI simulator was developed to run according to pulse sequences used in experiments. Experiments and simulations were performed to demonstrate the usefulness of the MRI simulator for three types of pulse sequences, namely, three-dimensional (3D) gradient-echo, 3D radio-frequency spoiled gradient-echo, and gradient-echo multislice with practical matrix sizes...
May 20, 2017: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/28550817/atypical-presentation-and-outcome-of-cervicogenic-headache-in-patients-with-cervical-degenerative-disease-a-single-center-experience
#2
Shyamal C Bir, Anil Nanda, Devi Prasad Patra, Tanmoy Kumar Maiti, Cesar Liendo, Minagar Alireza, Oleg Y Chernyshev
OBJECTIVE: Cervicogenic headache affects a significant portion of the entire population. This type of headache especially with atypical presentation is often hard to diagnose and manage since its etiopathophysiology is not been yet well understood. We have investigated the prevalence of cervicogenic headache with atypical presentation and discussed the etiology of it, and the outcome of surgical intervention on this type of headache in patients with cervical degenerative disease. PATIENTS AND METHODS: Radiological and clinical data of 160 patients (from 2001 through 2016) were retrospectively reviewed...
May 13, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28550811/influence-of-solids-residence-time-and-carbon-storage-on-nitrogen-and-phosphorus-recovery-by-microalgae-across-diel-cycles
#3
D A Gardner-Dale, I M Bradley, J S Guest
Microalgal treatment systems could advance nutrient recovery from wastewater by achieving effluent nitrogen (N) and phosphorus (P) levels below the current limit of technology, but their successful implementation requires an understanding of how design decisions influence nutrient uptake over daily (i.e., diel) cycles. This work demonstrates the ability to influence microalgal N:P recovery ratio via solids residence time (SRT) while maintaining complete nutrient removal across day/night cycles through carbon storage and mobilization...
May 18, 2017: Water Research
https://www.readbyqxmd.com/read/28550799/in%C3%A2-vivo-assessment-of-dermal-adhesion-penetration-and-bioavailability-of-tetrabromobisphenol-a
#4
Yunjiang Yu, Liangzhong Li, Hongyan Li, Xiaowei Yu, Yanping Zhang, Qiong Wang, Zhixiang Zhou, Dandan Gao, Hao Ye, Bigui Lin, Ruixue Ma
Individuals are exposed to brominated flame retardants (BFRs), including tetrabromobisphenol A (TBBPA), on a daily basis because of their widespread usage. These compounds may have adverse effects on human health. In the present study, dermal absorption experiments were conducted in vivo to predict the adhesion, penetration, and bioavailability of TBBPA. TBBPA was administered to Wistar rats for 6 h by repeated dermal exposure at doses of 20, 60, 200, and 600 mg of TBBPA per kg of body weight (bw). The skin adhesion coefficient (AC) was calculated using a difference-value method and ranged from 0...
May 24, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28550793/acute-gonadotropin-releasing-hormone-agonist-treatment-enhances-extinction-memory-in-male-rats
#5
L Y Maeng, M B Taha, K K Cover, S S Glynn, M Murillo, K Lebron-Milad, M R Milad
Leuprolide acetate (LEU), also known as Lupron, is commonly used to treat prostate cancer in men. As a gonadotropin-releasing hormone (GnRH) receptor agonist, it initially stimulates the release of gonadal hormones, testosterone (T) and estradiol. This surge eventually suppresses these hormones, preventing the further growth and spread of cancer cells. Individuals receiving this treatment often report anxiety and cognitive changes, but LEU's effects on the neural mechanisms that are involved in anxiety during the trajectory of treatment are not well known...
May 17, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28550763/mechanical-properties-of-a-nanoporous-membrane-used-in-implantable-medical-devices-correlation-between-experimental-characterization-and-2d-numerical-simulation
#6
F Cristofari, B Piotrowski, R Pesci
Nanoporous membranes are used for the elaboration of implantable medical devices. In order to guaranty their integrity after implantation in a patient body, it is necessary to characterize the microstructure and the mechanical behavior of such membranes. They present randomly distributed pores around 1µm in diameter at the surface. X-ray nanotomography permits to get the geometry of the pores through the thickness with a reduction of the diameter in the core. A multiscale study is done to characterize the membranes: macroscopic tensile tests permit to get the behavior law of the non porous material and in situ tensile tests are carried on in a Scanning Electron Microscope in order to observe the evolution of pores and cracks during loading...
May 18, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28550762/forensic-age-estimation-by-morphometric-analysis-of-the-manubrium-from-3d-mr-images
#7
Naira P Martínez Vera, Johannes Höller, Thomas Widek, Bernhard Neumayer, Thomas Ehammer, Martin Urschler
Forensic age estimation research based on skeletal structures focuses on patterns of growth and development using different bones. In this work, our aim was to study growth-related evolution of the manubrium in living adolescents and young adults using magnetic resonance imaging (MRI), which is an image acquisition modality that does not involve ionizing radiation. In a first step, individual manubrium and subject features were correlated with age, which confirmed a statistically significant change of manubrium volume (Mvol:p<0...
May 12, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28550749/a-novel-non-enzymatic-glucose-sensor-based-on-the-modification-of-carbon-paste-electrode-with-cuo-nanoflower-designing-the-experiments-by-response-surface-methodology-rsm
#8
Zahra Amani-Beni, Alireza Nezamzadeh-Ejhieh
A non enzymatic modified electrode was constructed based on the modification of carbon paste electrode with CuO nanoflower (CuO-CPE). The raw and modified samples were characterized by XRD, TEM, SEM-EDX and X-ray mapping techniques. The proposed CuO-CPE showed a well voltammetric peak pair in cyclic voltammetry which of peak currents were decreased in the presence of glucose. Hence, this decrease in peak current was used for voltammetric determination of glucose. To evaluate interactions between the influencing variables, experiments were designed by response surface methodology (RSM) and the results showed CuO%-pH have the most effect on square wave voltammetric response...
May 19, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28550744/evaluation-of-a-multi-site-program-designed-to-strengthen-relational-bonds-for-siblings-separated-by-foster-care
#9
Jeffrey Waid, Armeda Stevenson Wojciak
Sibling relationships in foster care settings have received increased attention in recent years. Despite growing evidence regarding the protective potential of sibling relationships for youth in care, some sibling groups continue to experience foster care related separation, and few programs exist to address the needs of these youth. This study describes and evaluates Camp To Belong, a multi-site program designed to provide short-term reunification to separated sibling groups through a week-long summer camp experience...
May 13, 2017: Evaluation and Program Planning
https://www.readbyqxmd.com/read/28550743/impact-of-drought-stress-on-specialised-metabolism-biosynthesis-and-the-expression-of-monoterpene-synthases-in-sage-salvia-officinalis
#10
Alzahraa Radwan, Maik Kleinwächter, Dirk Selmar
In previous experiments, we demonstrated that the amount of monoterpenes in sage is increased massively by drought stress. Our current study is aimed to elucidate whether this increase is due, at least in part, to elevated activity of the monoterpene synthases responsible for the biosynthesis of essential oils in sage. Accordingly, the transcription rates of the monoterpene synthases were analyzed. Salvia officinalis plants were cultivated under moderate drought stress. The concentrations of monoterpenes as well as the expression of the monoterpene synthases were analyzed...
May 24, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28550741/exploring-syndrome-differentiation-using-non-negative-matrix-factorization-and-cluster-analysis-in-patients-with-atopic-dermatitis
#11
Younghee Yun, Wonmo Jung, Hyunho Kim, Bo-Hyoung Jang, Min-Hee Kim, Jiseong Noh, Seong-Gyu Ko, Inhwa Choi
Syndrome differentiation (SD) results in a diagnostic conclusion based on a cluster of concurrent symptoms and signs, including pulse form and tongue color. In Korea, there is a strong interest in the standardization of Traditional Medicine (TM). In order to standardize TM treatment, standardization of SD should be given priority. The aim of this study was to explore the SD, or symptom clusters, of patients with atopic dermatitis (AD) using non-negative factorization methods and k-means clustering analysis...
May 22, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28550732/reversing-the-polarization-of-tumor-associated-macrophages-inhibits-tumor-metastasis
#12
Rufei Yuan, Shengfu Li, Hua Geng, Xin Wang, Qinglin Guan, Xiaohuan Li, Changle Ren, Xiaolin Yuan
OBJECTIVE: The M2 phenotype is dominant in tumor associated macrophages (TAM), and plays a key role in promoting tumor growth, invasion and metastasis. Converting TAM polarization from M2 to M1 may contribute to eliciting anti-tumor-specific immune responses and inhibiting tumor metastasis. In this study, the effect of reversing the polarization of TAM on tumor metastasis was investigated. METHODS: Peritoneal macrophages were obtained from BABL/c mice, and M2 polarization was induced by IL-4...
May 24, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28550725/geographical-variation-and-age-related-dietary-exposure-to-arsenic-in-rice-from-bangladesh
#13
Shofiqul Islam, Mohammad Mahmudur Rahman, M R Islam, Ravi Naidu
An extensive number (965) of rice samples collected by household survey from 73 upazilas (i.e. sub-districts) in Bangladesh was analyzed to determine regional variation, distribution and associated health risks from arsenic (As). No previous study had conducted a study examining such a large number of rice samples. The mean and median concentrations of total As were 126μg/kg and 107μg/kg, respectively, ranging from between 3 and 680μg/kg. Importantly, total As levels of aromatic rice were significantly lower (average 58μg/kg) than non-aromatic rice (average 150μg/kg) and also varied with rice grain size...
May 24, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28550712/combined-immune-checkpoint-blockade-anti-pd-1-anti-ctla-4-evaluation-and-management-of-adverse-drug-reactions
#14
REVIEW
Jessica C Hassel, Lucie Heinzerling, Jens Aberle, Oliver Bähr, Thomas K Eigentler, Marc-Oliver Grimm, Victor Grünwald, Jan Leipe, Niels Reinmuth, Julia K Tietze, Jörg Trojan, Lisa Zimmer, Ralf Gutzmer
Combined immune checkpoint blockade (ICB) provides unprecedented efficacy gains in numerous cancer indications, with PD-1 inhibitor nivolumab plus CTLA-4 inhibitor ipilimumab in advanced melanoma as first-ever approved therapies for combined ICB. However, gains in efficacy must be balanced against a higher frequency and severity of adverse drug reactions (ADR). Because delays in diagnosis and management might result in symptom worsening and further complications, clinicians shall be well trained to identify ADR promptly and monitor patients adequately...
May 18, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/28550710/type-1-diabetes-increases-retention-of-low-density-lipoprotein-in-the-atherosclerosis-prone-area-of-the-murine-aorta
#15
Mette K Hagensen, Martin Bødtker Mortensen, Mads Kjolby, Ninna L Stillits, Lasse B Steffensen, Jacob F Bentzon
BACKGROUND AND AIMS: Individuals with type 1 diabetes mellitus are at high risk of developing atherosclerotic cardiovascular disease, but the underlying mechanisms by which type 1 diabetes accelerates atherosclerosis remain unknown. Increased retention of low-density lipoprotein (LDL) in atherosclerosis-prone sites of the diabetic vascular wall has been suggested, but direct evidence is lacking. In the present study, we investigated whether retention of LDL is increased in atherosclerotic-prone areas using a murine model of type 1 diabetes...
May 18, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28550705/the-effect-of-language-on-hospital-inpatient-length-of-stay
#16
Nirbhai Singh Pannu, Alexandra Hill-Mann, Gurwinder Gill
As one of the most ethnically diverse countries in the world, Canada is faced with numerous challenges in addressing disparities affecting its healthcare system. One barrier to care is limited English proficiency (LEP). Using electronic medical records, this retrospective study examined the impact of LEP on inpatient length of stay (LOS) in an acute care community hospital. We found that patients in our sample population with LEP had a shorter inpatient LOS by 0.36 days compared with English-proficient (EP) patients...
2017: Healthcare Quarterly
https://www.readbyqxmd.com/read/28550704/integrating-engagement-and-improvement-work-in-a-pediatric-hospital
#17
Mireille Brosseau, Diane Gagnon, Kristina Rohde, Jennifer Schellinck
Although geared towards a common goal - improved patient-centred care - quality improvement strategies and patient engagement-focused approaches are often developed and conducted in silos. The lack of integration may lead, on the one hand, to the uptake of patient suggestions that do not always take into consideration implications for the delivery of quality care and, on the other hand, to inadequate understanding of patient views required to create optimal services. The Children's Hospital of Eastern Ontario (CHEO)'s action plans to address gaps in patient engagement and quality improvement, two of its priority areas, were initially carried out in isolation of each other...
2017: Healthcare Quarterly
https://www.readbyqxmd.com/read/28550703/improving-patient-engagement-and-satisfaction-lessons-from-a-patient-driven-care-initiative-in-a-community-based-hospital
#18
Lisa Shiozaki, Kirsten Burgomaster, Manon Lemonde
Lack of collaboration and alignment between members of the healthcare team interfere with the patient-centred care approach. The Patient-Driven Care Project was initiated in 2012. This model sought to advance a system of care that is patient-driven, family-centred and provider-guided to improve the value to patients and give them more control on their health journey. The evaluation revealed that the efforts should focus on sustainability and continuation of support and encouragement of hospital colleagues to ensure each patient and family experience is based on caring communication at every interaction with them...
2017: Healthcare Quarterly
https://www.readbyqxmd.com/read/28550702/listening-to-improve-transforming-patient-relations-measurement-and-reporting-in-ontario
#19
Patricia Sullivan-Taylor, Rachel Frohlich, Anita Singh, Anna Greenberg
Effective patient relations are important to improve patient experience and deliver better care. Policy and legislative changes in Ontario have increased accountabilities for patient relations and expanded Health Quality Ontario (HQO)'s mandate. In response, HQO collaborated with patients, health sector organizations, associations and the Ministry of Health and Long-Term Care to co-design a patient relations measurement and reporting approach. Informed by an environmental scan, broad consultations, a multi-sector survey and a provincial advisory group, the approach includes standardized patient relations indicators to support measurement and public reporting across the hospital, home and long-term care sectors...
2017: Healthcare Quarterly
https://www.readbyqxmd.com/read/28550688/long-noncoding-rna-crnde-prc2-participated-in-the-radiotherapy-resistance-of-human-lung-adenocarcinoma-through-targeting-p21-expression
#20
Ming Zhang, Change Gao, Yi Yang, Gaofeng Li, Jian Dong, Yiqin Ai, Nan Chen, Wenhui Li
Long noncoding RNAs (lncRNAs), as new class of functional regulators involved in human tumorigenesis, have been attracting increasing attention of researchers. The lncRNA Colorectal Neoplasia Differentially Expressed (CRNDE), transcribed from chromosome 16 on the strand opposite to the adjacent IRX5 gene, were originally found to be increased in CRC and was reported abnormal expressed in many cancers. However, its potential role and molecular mechanism underlying radioresistant phenotype formation of lung adenocarcinoma (LAD) remains unclear...
May 17, 2017: Oncology Research
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