Bo Pang, Nan Wu, Rongwei Guan, Lin Pang, Xinlei Li, Su Li, Liudi Tang, Ying Guo, Jialei Chen, Donglin Sun, Haiming Sun, Jialin Dai, Jing Bai, Guohua Ji, Peng Liu, An Liu, Qiushi Wang, Sheng Xiao, Songbin Fu, Yan Jin
Purpose: Investigate the role of regulator of chromosome condensation 2 ( RCC2 ) on lung adenocarcinoma (LUAD) metastasis. Experimental Design: Clinical specimens were used to assess the impact of RCC2 on LUAD metastasis. Mouse models, cytobiology, and molecular biology assays were performed to elucidate the function and underlying mechanisms of RCC2 in LUAD. Results: RCC2 expression was frequently increased in LUADs (88/122, 72.13%). It was confirmed by analysis of a larger cohort of TCGA RNA-seq data containing 488 LUADs and 58 normal lung tissues ( P < 0...
September 15, 2017: Clinical Cancer Research