Zhihua Ren, Tingting Ku, Yurou Gao, Xiaoxi Yang, Lingyi Meng, Qian S Liu, Jiefeng Liang, Hanqing Xu, Chunyang Liao, Qunfang Zhou, Francesco Faiola, Guibin Jiang
The neurodevelopmental process is highly vulnerable to environmental stress from exposure to endocrine-disrupting chemicals. Perfluorinated iodine alkanes (PFIs) possess estrogenic activities, while their potential neurodevelopmental toxicity remains blurry. In the present study, the effects of two PFIs, including dodecafluoro-1,6-diiodohexane (PFHxDI) and tridecafluorohexyl iodide (PFHxI), were investigated in the neural differentiation of the mouse embryonic stem cells (mESCs). Without influencing the cytobiological process of the mESCs, PFIs interfered the triploblastic development by increasing ectodermal differentiation, thus promoting subsequent neurogenesis...
June 21, 2022: Environmental Science & Technology