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Trageted therapy

Zhonghua Ma, Hesuyuan Huang, Jirong Wang, Yan Zhou, Fuxing Pu, Qinghong Zhao, Peng Peng, Bingqing Hui, Hao Ji, Keming Wang
Long non-coding RNA (lncRNA) is emerging as an critical regulator in multiple cancers, including pancreatic cancer (PC). Recently, lncRNA SNHG15 was found to be up-regulated in gastric cancer and hepatocellular carcinoma, exerting oncogenic effects. Nevertheless, the biological function and regulatory mechanism of SNHG15 remain unclear in pancreatic cancer (PC). In this study, we reported that SNHG15 expression was also upregulated in PC tissues, and its overexpression was remarkably associated with tumor size, tumor node metastasis (TNM) stage and lymph node metastasis in patients with PC...
October 13, 2017: Oncotarget
Suzana Tunuković, Franjo Frnjić, Silvija Loncar
No abstract text is available yet for this article.
October 2013: Acta Medica Croatica: C̆asopis Hravatske Akademije Medicinskih Znanosti
Hisashi Nakamura, Shinzo Takamori, Teruhiko Fujii, Mayumi Ono, Hideaki Yamana, Michihiko Kuwano, Kazuo Shirouzu
An important recent advance in anticancer therapy was the development of molecular-targeting drugs, such as the epidermal growth-factor receptor (EGFR)-targeting drug ZD1839 (Iressa) and the HER2-trageting anti-HER2 monoclonal antibody trastuzumab (Herceptin). ZD1839 and trastuzumab are reported to improve the therapeutic efficacy of treatment for non-small-cell lung cancer (NSCLC) and breast cancer, respectively, although the effectiveness of either drug alone is not satisfactory. NSCLC cells often express both EGFR and HER2...
December 8, 2005: Cancer Letters
Dawn M Carlson, Joyce L Steinberg, Gary Gordon
While significant advances in the treatment of cancer occured during the last half of the twentieth century, parallel decreases in overall cancer death rates were not observed. Cancer therapy remains an area of significant unmet medical need. Abbott's oncology research programs are focused on pioneering trageted, less toxic therapies, aimed at different aspects of tumor growth and development. Oncology drugs in development at Abbott target several mechanisms of cancer progression by interfering with multiple processes necessary for tumor growth: recruitment of a blood supply, cell proliferation, and the development of metastases...
September 2005: Clinical Advances in Hematology & Oncology: H&O
S Quan, G Pan, C Lu, D Liu, F Fang
OBJECTIVE: To investigate the alpha-fetoprotein (AFP)-specific promoter mediated target gene therapy of hepatocellular carcinoma in vitro. METHODS: Retroviral vector (LX2.2CD) in which the cytosine deaminase (CD) gene was driven by the 2.2 kb recombinant human AFP TRS. After transfecting three human hepatoma cell lines and one non-hepatoma cell line with LX2.2 CD, anti-G418 clones integrated CD gene were selected, and inhibitory experiment of cell growth was performed...
April 1999: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
Z Kasztelan
On the basis of 404 transurethral resections of tumours of the urinary bladder a report is given on complications and their prevention. Among 404 tumour resections 4 perforations of the bladder occurred (0.9%). The extraperitoneal perforations were simply paravesically drained; the intraperitoneal ones were oversewn and intraperitoneally drained. Post-operative bleeding was well controlled by means of a continuous wash via an additional thin catheter (Charr. 7-8) fitted into the urethra. Patients with existing infections of the urinary passages were traget-specifically treated with antibiotics...
June 1983: Zeitschrift Für Urologie und Nephrologie
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