M Constanza Camargo, Minkyo Song, Xia Xu, Isaac Zhao, Joshua N Sampson, Arash Etemadi, Hermann Brenner, Hwi-Won Lee, Britton Trabert, Bernd Holleczek, Ben Schöttker, Kathleen Spaid, Sanford M Dawsey, Sangjun Lee, Takaya Shimura, Sue K Park, Reza Malekzadeh, Daehee Kang, Charles S Rabkin
BACKGROUND: The overall incidence of gastric cancer in women is half that in men for most global populations. Sex hormone pathways may be involved in carcinogenesis and estrogens have been postulated to protect women against gastric cancer. AIM: To evaluate associations of gastric cancer with estrogen metabolites in postmenopausal women. METHODS AND RESULTS: We performed an analysis of 233 gastric cancer cases and 281 age-matched controls from three prospective cohorts and two case-control studies of early-stage gastric cancer, mainly conducted in high-risk Asian populations...
November 11, 2021: Cancer reports