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urinary estrone

Jay L Lieberman, Mary Jane De Souza, David A Wagstaff, Nancy I Williams
INTRODUCTION: Chronic reductions in energy availability (EA) suppress reproductive function. A particular calculation of EA quantifies the dietary energy remaining after exercise for all physiological functions. Reductions in LH pulse frequency have been demonstrated when EA using this calculation is < 30 kcal/ kg ffm·d. PURPOSE: We determined whether menstrual disturbances (MD) are induced when EA is < 30 kcal/ kg ffm·d. METHODS: Thirty-five sedentary, ovulatory women 18-24 yr (weight= 59...
October 10, 2017: Medicine and Science in Sports and Exercise
Xin Fang, Lei Wang, Chunhua Wu, Huijing Shi, Zhijun Zhou, Scott Montgomery, Yang Cao
Measurement of endogenous hormones in early life is important to investigate the effects of hormonally active environmental compounds. To assess the possible hormonal effects of different feeding regimens in different sample matrices of infants, 166 infants were enrolled from two U.S hospitals between 2006 and 2009. The children were classified into exclusive soy formula, cow milk formula or breast milk regimens. Urine, saliva and blood samples were collected over the first 12 months of life. Estradiol, estrone, testosterone, luteinizing hormone (LH), follicle-stimulating hormone (FSH) and sex hormone-binding globulin (SHBG) levels were measured in the three matrices...
June 28, 2017: Scientific Reports
Vincent T Martin, Janelle R Allen, Timothy T Houle, Scott W Powers, Marielle A Kabbouche, Hope L O'Brien, Joanne Kacperski, Susan L LeCates, Shannon White, Polly Vaughan, Karen Mandell, Andrew D Hershey
Background Fifty-three percent of adolescent girls report headaches at the onset of menses, suggesting fluctuations of ovarian hormones trigger migraine during puberty. Aims To determine if urinary metabolites of estrogen and progesterone are associated with days of headache onset (HO) or severity in girls with migraine. Methods This was a pilot study and included 34 girls with migraine balanced across three age strata (pre-pubertal (8-11), pubertal (12-15), and post-pubertal (16-17) years of age). They collected daily urine samples and recorded the occurrence and severity of headache in a daily diary...
January 1, 2017: Cephalalgia: An International Journal of Headache
Nanette Santoro, Sybil L Crawford, Samar R El Khoudary, Amanda A Allshouse, Sherri-Ann Burnett-Bowie, Joel Finkelstein, Carol Derby, Karen Matthews, Howard M Kravitz, Sioban D Harlow, Gail A Greendale, Ellen B Gold, Rasa Kazlauskaite, Dan McConnell, Genevieve Neal-Perry, Jelena Pavlovic, John Randolph, Gerson Weiss, Hsiang-Yu Chen, Bill Lasley
Context: Menstrual cycle hormone patterns in women approaching menopause are inadequately studied. Objective: To describe day-to-day menstrual cycle hormones in women as they approach menopause from the Study of Women's Health Across the Nation Daily Hormone Study (DHS). Design: DHS enrollees collected daily urine for one entire menstrual cycle or up to 50 days, whichever came first, annually, up to the final menstrual period (FMP) or for up to 10 years...
July 1, 2017: Journal of Clinical Endocrinology and Metabolism
Sheela Sathyanarayana, Samantha Butts, Christina Wang, Emily Barrett, Ruby Nguyen, Stephen M Schwartz, Wren Haaland, Shanna H Swan
Context: Adequate sex steroid hormone concentrations are essential for normal fetal genital development in early pregnancy. Our previous study demonstrated an inverse relationship between third-trimester di-2-ethyl hexyl phthalate exposure and total testosterone (TT) concentrations. Here, we examine early-pregnancy phthalates, sex steroid hormone concentrations, and newborn reproductive outcomes. Design: We examined associations between urinary phthalate metabolite concentrations in early pregnancy and serum free testosterone (FT), TT, estrone (E1), and estradiol (E2) in 591 woman/infant dyads in The Infant Development and Environment Study; we also examined relationships between hormones and newborn genital outcomes using multiple regression models with covariate adjustment...
June 1, 2017: Journal of Clinical Endocrinology and Metabolism
Ulrike Luderer, Fletcher Christensen, Wesley O Johnson, Jianwen She, Ho Sai Simon Ip, Junqiang Zhou, Josephine Alvaran, Edward F Krieg, James S Kesner
Essentially all women are exposed to polycyclic aromatic hydrocarbons (PAHs), formed during incomplete combustion of organic materials, including fossil fuels, wood, foods, and tobacco. PAHs are ovarian toxicants in rodents, and cigarette smoking is associated with reproductive abnormalities in women. Biomonitoring of hydroxylated PAH (OH-PAH) metabolites in urine provides an integrated measure of exposure to PAHs via multiple routes and has been used to characterize exposure to PAHs in humans. We hypothesized that concentrations of OH-PAHs in urine are associated with reproductive function in women...
March 2017: Environment International
E A Southmayd, R J Mallinson, N I Williams, D J Mallinson, M J De Souza
Many female athletes are energy and/or estrogen deficient, but the independent effects on bone health have not been isolated. Energy deficiency was detrimental at the tibia while estrogen deficiency was detrimental at the radius. Nutrition must be considered alongside menstrual recovery when addressing compromised bone health in female athletes. INTRODUCTION: The purpose of this study was to describe volumetric bone mineral density (vBMD), bone geometry, and estimated bone strength in exercising women (n = 60) grouped according to energy status (energy replete (EnR: n = 30) vs...
April 2017: Osteoporosis International
Gertraud Maskarinec, Dan Ju, Yukiko Morimoto, Adrian A Franke, Frank Z Stanczyk
Soy foods may protect against breast cancer in Asian but not in Western populations. We examined if the levels of various markers of breast cancer risk and inflammation, as well as the effects of soy food consumption on these markers, differ between Asian and non-Asian premenopausal women in two soy intervention trials. One study randomized 220 women to a 2-yr intervention and the other one randomized 96 women in a crossover design to examine the effects of consumption of 2 daily soy servings on nipple aspirate fluid (NAF) volume; estrogens in serum, NAF, and urine; insulin-like growth factor-1 (IGF-1), IGF-binding protein 3, and inflammatory markers in serum; and mammographic densities...
January 2017: Nutrition and Cancer
Sangmi Kim, Jeff Campbell, Wonsuk Yoo, Jack A Taylor, Dale P Sandler
Background: Prostaglandin E2 (PGE2) induces aromatase expression in adipose tissue, leading to increased estrogen production that may promote the development and progression of breast cancer. However, few studies have simultaneously investigated systemic levels of PGE2 and estrogen in relation to postmenopausal breast cancer risk.Methods: Here, we determined urinary estrogen metabolites (EM) using mass spectrometry in a case-cohort study (295 incident breast cancer cases and 294 subcohort members), and using linear regression estimated the effect of urinary levels of a major PGE2 metabolite (PGE-M) on EMs...
March 2017: Cancer Epidemiology, Biomarkers & Prevention
Kodzue Kinoshita, Yusuke Sano, Akira Takai, Mika Shimizu, Toshio Kobayashi, Akihiro Ouchi, Noko Kuze, Miho Inoue-Murayama, Gen'ichi Idani, Munehiro Okamoto, Yasuhiko Ozaki
BACKGROUND: Under the environment of pregnancy, the placenta assumes an important steroidogenic role in the maintenance of pregnancy. METHODS: Urinary placental leucine aminopeptidase (PLAP), estrone-3-glucuronide (E1 G), and pregnanediol-3-glucuronide (PdG) concentrations were compared among five pregnancies (four live births and one stillbirth) in four orangutans. RESULTS: The gestation period of the stillbirth (223 days) was shorter than that of the live births (239-254 days)...
February 2017: Journal of Medical Primatology
Lauren Johnson, Mary D Sammel, Allison Schanne, Lara Lechtenberg, Maureen Prewitt, Clarisa Gracia
OBJECTIVE: To evaluate reproductive hormone patterns in women exposed to alkylating-agent chemotherapy. DESIGN: Prospective cohort. SETTING: University hospital. PATIENT(S): Normally menstruating mid-reproductive-age women (20-35 years old) who had previously been exposed to alkylating-agent chemotherapy for cancer treatment were compared with two healthy control populations: similarly-aged women and late-reproductive-age women (43-50 years old)...
December 2016: Fertility and Sterility
Katherine M Graham, Andrew J Kouba, Cecilia J Langhorne, Ruth M Marcec, Scott T Willard
BACKGROUND: Accurate sex identification techniques are important for wildlife demographic studies and for genetic management of captive breeding colonies. Various non-invasive methods for identification of biological sex in the weakly dimorphic endangered dusky gopher frog (DGF; Lithobates sevosa) were explored to support planned recovery efforts for this species including breeding and augmentation of wild populations. METHODS: Body size (snout-vent length and body weight) measurements, observation of nuptial pads, ultrasound imaging, and urinary hormone analysis for testosterone and estrone were performed on 27 male and 19 female DGFs...
August 2, 2016: Reproductive Biology and Endocrinology: RB&E
Steven C Moore, Charles E Matthews, Xiao Ou Shu, Kai Yu, Mitchell H Gail, Xia Xu, Bu-Tian Ji, Wong-Ho Chow, Qiuyin Cai, Honglan Li, Gong Yang, David Ruggieri, Jennifer Boyd-Morin, Nathaniel Rothman, Robert N Hoover, Yu-Tang Gao, Wei Zheng, Regina G Ziegler
BACKGROUND: The role of estrogen metabolism in determining breast cancer risk and differences in breast cancer rates between high-incidence and low-incidence nations is poorly understood. METHODS: We measured urinary concentrations of estradiol and estrone (parent estrogens) and 13 estrogen metabolites formed by irreversible hydroxylation at the C-2, C-4, or C-16 positions of the steroid ring in a nested case-control study of 399 postmenopausal invasive breast cancer case participants and 399 matched control participants from the population-based Shanghai Women's Health Study cohort...
October 2016: Journal of the National Cancer Institute
Nichola Johnson, Paolo De Ieso, Gabriele Migliorini, Nick Orr, Peter Broderick, Daniel Catovsky, Athena Matakidou, Timothy Eisen, Christy Goldsmith, Frank Dudbridge, Julian Peto, Isabel Dos-Santos-Silva, Alan Ashworth, Gillian Ross, Richard S Houlston, Olivia Fletcher
CYP3A enzymes metabolize endogenous hormones and chemotherapeutic agents used to treat cancer, thereby potentially affecting drug effectiveness. Here, we refined the genetic basis underlying the functional effects of a CYP3A haplotype on urinary estrone glucuronide (E1G) levels and tested for an association between CYP3A genotype and outcome in patients with chronic lymphocytic leukemia (CLL), breast, or lung cancers. The most significantly associated SNP was rs45446698, an SNP that tags the CYP3A7*1C allele; this SNP was associated with a 54% decrease in urinary E1G levels...
March 15, 2016: Cancer Research
Cher M Dallal, Louise A Brinton, Charles E Matthews, Ruth M Pfeiffer, Terryl J Hartman, Jolanta Lissowska, Roni T Falk, Montserrat Garcia-Closas, Xia Xu, Timothy D Veenstra, Gretchen L Gierach
PURPOSE: Physical activity may reduce endogenous estrogens, but few studies have assessed effects on estrogen metabolism and none have evaluated sedentary behavior in relation to estrogen metabolism. We assessed relationships between accelerometer-measured physical activity and sedentary behavior and 15 urinary estrogens and estrogen metabolites (EM) among postmenopausal controls from a population-based breast cancer case-control study conducted in Poland (2000-2003). METHODS: Postmenopausal women (N = 542) were ages 40 to 72 yr and not currently using hormone therapy...
March 2016: Medicine and Science in Sports and Exercise
David X Li, Sarah Romans, Mary Jane De Souza, Brian Murray, Gillian Einstein
BACKGROUND: Sleep and mood disturbances in women have often been linked to the menstrual cycle, implying an ovarian hormonal causation. However, most studies in this area have used self-reported menstrual cycle phase rather than direct measurement of ovarian hormone concentrations. Further, many studies have focused primarily on peri- and postmenopausal populations reporting clinical sleep difficulty. In this study, we examined the associations among sleep quality, mood, and ovarian hormone concentration in a random sample of community-dwelling, nonclinical women of reproductive age...
October 2015: Sleep Medicine
Judith Roos, Sarah Johnson, Sarah Weddell, Erhard Godehardt, Julia Schiffner, Günter Freundl, Christian Gnoth
OBJECTIVE: The aim of the study was to examine relationships and interindividual variations in urinary and serum reproductive hormone levels relative to ultrasound-observed ovulation in menstrual cycles of apparently normally menstruating women. METHODS: This was a prospective study of normally menstruating women (no known subfertility), aged 18-40 years (n = 40), who collected daily urine samples and attended the study centre for blood samples and transvaginal ultrasound during one complete menstrual cycle...
2015: European Journal of Contraception & Reproductive Health Care
P A Nepomnaschy, K G Salvante, L Zeng, C Pyles, H Ma, J C Blais, L Wen, C K Barha
STUDY QUESTION: How do women's first morning urinary cortisol levels, a marker of stress axis activity, vary during the peri-conceptional period (the 12 weeks around conception)? SUMMARY ANSWER: First morning urinary cortisol follows an overall increasing trajectory across the peri-conceptional period, interrupted by 2 week-long decreases during the week preceding conception and the fifth week following conception. WHAT IS KNOWN ALREADY: Later gestational stages (i...
June 2015: Human Reproduction
Ze-Hua Liu, Gui-Ning Lu, Hua Yin, Zhi Dang
Natural estrogens are important endocrine disrupting compounds (EDCs), which may pose adverse effects on our environment. To avoid time-consuming sample preparation and chemical analysis, estimation of their concentrations in municipal wastewater based on their human urine/feces excretion rates has been generally adopted. However, the data of excretion rates available are very limited and show significant difference among countries. In the context of increasing reporting on the concentrations of natural estrogens in municipal wastewater around the world, this study presented a simple method to estimate their human excretion rates based on the concentrations of natural estrogens in raw sewage...
June 2015: Environmental Science and Pollution Research International
Sarah Johnson, Sarah Weddell, Sonya Godbert, Guenter Freundl, Judith Roos, Christian Gnoth
BACKGROUND: Urinary hormone level analysis provides valuable fertility status information; however, previous studies have not referenced levels to the ovulation day, or have used outdated methods. This study aimed to produce reproductive hormone ranges referenced to ovulation day determined by ultrasound. METHODS: Women aged 18-40 years (no reported infertility) collected daily urine samples for one complete menstrual cycle. Urinary luteinising hormone (LH), estrone-3-glucuronide (E3G, an estradiol metabolite), follicle stimulating hormone (FSH) and pregnanediol-3-glucuronide (P3G, a progesterone metabolite) were measured using previously validated assays...
June 2015: Clinical Chemistry and Laboratory Medicine: CCLM
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