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https://www.readbyqxmd.com/read/27918846/soy-food-intake-and-biomarkers-of-breast-cancer-risk-possible-difference-in-asian-women
#1
Gertraud Maskarinec, Dan Ju, Yukiko Morimoto, Adrian A Franke, Frank Z Stanczyk
Soy foods may protect against breast cancer in Asian but not in Western populations. We examined if the levels of various markers of breast cancer risk and inflammation, as well as the effects of soy food consumption on these markers, differ between Asian and non-Asian premenopausal women in two soy intervention trials. One study randomized 220 women to a 2-yr intervention and the other one randomized 96 women in a crossover design to examine the effects of consumption of 2 daily soy servings on nipple aspirate fluid (NAF) volume; estrogens in serum, NAF, and urine; insulin-like growth factor-1 (IGF-1), IGF-binding protein 3, and inflammatory markers in serum; and mammographic densities...
December 5, 2016: Nutrition and Cancer
https://www.readbyqxmd.com/read/27864342/systemic-levels-of-estrogens-and-pge2-synthesis-in-relation-to-postmenopausal-breast-cancer-risk
#2
Sangmi Kim, Jeff Campbell, Wonsuk Yoo, Jack A Taylor, Dale P Sandler
BACKGROUND: Prostaglandin E2 (PGE2) induces aromatase expression in adipose tissue leading to increased estrogen production that may promote the development and progression of breast cancer. However, few studies have simultaneously investigated systemic levels of PGE2 and estrogen in relation to postmenopausal breast cancer risk. METHODS: Here we determined urinary estrogen metabolites (EMs) using mass spectrometry in a case-cohort study (295 incident breast cancer cases and 294 subcohort members), and using linear regression estimated the effect of urinary levels of a major PGE2 metabolite (PGE-M) on EMs...
November 18, 2016: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/27859398/urinary-sex-steroid-hormone-and-placental-leucine-aminopeptidase-concentration-differences-between-live-births-and-stillbirth-of-bornean-orangutans-pongo-pygmaeus
#3
Kodzue Kinoshita, Yusuke Sano, Akira Takai, Mika Shimizu, Toshio Kobayashi, Akihiro Ouchi, Noko Kuze, Miho Inoue-Murayama, Gen'ichi Idani, Munehiro Okamoto, Yasuhiko Ozaki
BACKGROUND: Under the environment of pregnancy, the placenta assumes an important steroidogenic role in the maintenance of pregnancy. METHODS: Urinary placental leucine aminopeptidase (PLAP), estrone-3-glucuronide (E1 G), and pregnanediol-3-glucuronide (PdG) concentrations were compared among five pregnancies (four live births and one stillbirth) in four orangutans. RESULTS: The gestation period of the stillbirth (223 days) was shorter than that of the live births (239-254 days)...
November 17, 2016: Journal of Medical Primatology
https://www.readbyqxmd.com/read/27666565/female-cancer-survivors-exposed-to-alkylating-agent-chemotherapy-have-unique%C3%A2-reproductive-hormone-profiles
#4
Lauren Johnson, Mary D Sammel, Allison Schanne, Lara Lechtenberg, Maureen Prewitt, Clarisa Gracia
OBJECTIVE: To evaluate reproductive hormone patterns in women exposed to alkylating-agent chemotherapy. DESIGN: Prospective cohort. SETTING: University hospital. PATIENT(S): Normally menstruating mid-reproductive-age women (20-35 years old) who had previously been exposed to alkylating-agent chemotherapy for cancer treatment were compared with two healthy control populations: similarly-aged women and late-reproductive-age women (43-50 years old)...
December 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27484119/biological-sex-identification-in-the-endangered-dusky-gopher-frog-lithobates-sevosa-a-comparison-of-body-size-measurements-secondary-sex-characteristics-ultrasound-imaging-and-urinary-hormone-analysis-methods
#5
Katherine M Graham, Andrew J Kouba, Cecilia J Langhorne, Ruth M Marcec, Scott T Willard
BACKGROUND: Accurate sex identification techniques are important for wildlife demographic studies and for genetic management of captive breeding colonies. Various non-invasive methods for identification of biological sex in the weakly dimorphic endangered dusky gopher frog (DGF; Lithobates sevosa) were explored to support planned recovery efforts for this species including breeding and augmentation of wild populations. METHODS: Body size (snout-vent length and body weight) measurements, observation of nuptial pads, ultrasound imaging, and urinary hormone analysis for testosterone and estrone were performed on 27 male and 19 female DGFs...
2016: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/27193440/endogenous-estrogens-estrogen-metabolites-and-breast-cancer-risk-in-postmenopausal-chinese-women
#6
Steven C Moore, Charles E Matthews, Xiao Ou Shu, Kai Yu, Mitchell H Gail, Xia Xu, Bu-Tian Ji, Wong-Ho Chow, Qiuyin Cai, Honglan Li, Gong Yang, David Ruggieri, Jennifer Boyd-Morin, Nathaniel Rothman, Robert N Hoover, Yu-Tang Gao, Wei Zheng, Regina G Ziegler
BACKGROUND: The role of estrogen metabolism in determining breast cancer risk and differences in breast cancer rates between high-incidence and low-incidence nations is poorly understood. METHODS: We measured urinary concentrations of estradiol and estrone (parent estrogens) and 13 estrogen metabolites formed by irreversible hydroxylation at the C-2, C-4, or C-16 positions of the steroid ring in a nested case-control study of 399 postmenopausal invasive breast cancer case participants and 399 matched control participants from the population-based Shanghai Women's Health Study cohort...
October 2016: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/26964624/cytochrome-p450-allele-cyp3a7-1c-associates-with-adverse-outcomes-in-chronic-lymphocytic-leukemia-breast-and-lung-cancer
#7
Nichola Johnson, Paolo De Ieso, Gabriele Migliorini, Nick Orr, Peter Broderick, Daniel Catovsky, Athena Matakidou, Timothy Eisen, Christy Goldsmith, Frank Dudbridge, Julian Peto, Isabel Dos-Santos-Silva, Alan Ashworth, Gillian Ross, Richard S Houlston, Olivia Fletcher
CYP3A enzymes metabolize endogenous hormones and chemotherapeutic agents used to treat cancer, thereby potentially affecting drug effectiveness. Here, we refined the genetic basis underlying the functional effects of a CYP3A haplotype on urinary estrone glucuronide (E1G) levels and tested for an association between CYP3A genotype and outcome in patients with chronic lymphocytic leukemia (CLL), breast, or lung cancers. The most significantly associated SNP was rs45446698, an SNP that tags the CYP3A7*1C allele; this SNP was associated with a 54% decrease in urinary E1G levels...
March 15, 2016: Cancer Research
https://www.readbyqxmd.com/read/26460631/association-of-active-and-sedentary-behaviors-with-postmenopausal-estrogen-metabolism
#8
Cher M Dallal, Louise A Brinton, Charles E Matthews, Ruth M Pfeiffer, Terryl J Hartman, Jolanta Lissowska, Roni T Falk, Montserrat Garcia-Closas, Xia Xu, Timothy D Veenstra, Gretchen L Gierach
PURPOSE: Physical activity may reduce endogenous estrogens, but few studies have assessed effects on estrogen metabolism and none have evaluated sedentary behavior in relation to estrogen metabolism. We assessed relationships between accelerometer-measured physical activity and sedentary behavior and 15 urinary estrogens and estrogen metabolites (EM) among postmenopausal controls from a population-based breast cancer case-control study conducted in Poland (2000-2003). METHODS: Postmenopausal women (N = 542) were ages 40 to 72 yr and not currently using hormone therapy...
March 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/26429749/actigraphic-and-self-reported-sleep-quality-in-women-associations-with-ovarian-hormones-and-mood
#9
David X Li, Sarah Romans, Mary Jane De Souza, Brian Murray, Gillian Einstein
BACKGROUND: Sleep and mood disturbances in women have often been linked to the menstrual cycle, implying an ovarian hormonal causation. However, most studies in this area have used self-reported menstrual cycle phase rather than direct measurement of ovarian hormone concentrations. Further, many studies have focused primarily on peri- and postmenopausal populations reporting clinical sleep difficulty. In this study, we examined the associations among sleep quality, mood, and ovarian hormone concentration in a random sample of community-dwelling, nonclinical women of reproductive age...
October 2015: Sleep Medicine
https://www.readbyqxmd.com/read/26018113/monitoring-the-menstrual-cycle-comparison-of-urinary-and-serum-reproductive-hormones-referenced-to-true-ovulation
#10
COMPARATIVE STUDY
Judith Roos, Sarah Johnson, Sarah Weddell, Erhard Godehardt, Julia Schiffner, Günter Freundl, Christian Gnoth
OBJECTIVE: The aim of the study was to examine relationships and interindividual variations in urinary and serum reproductive hormone levels relative to ultrasound-observed ovulation in menstrual cycles of apparently normally menstruating women. METHODS: This was a prospective study of normally menstruating women (no known subfertility), aged 18-40 years (n = 40), who collected daily urine samples and attended the study centre for blood samples and transvaginal ultrasound during one complete menstrual cycle...
2015: European Journal of Contraception & Reproductive Health Care
https://www.readbyqxmd.com/read/25904636/variation-in-maternal-urinary-cortisol-profiles-across-the-peri-conceptional-period-a-longitudinal-description-and-evaluation-of-potential-functions
#11
P A Nepomnaschy, K G Salvante, L Zeng, C Pyles, H Ma, J C Blais, L Wen, C K Barha
STUDY QUESTION: How do women's first morning urinary cortisol levels, a marker of stress axis activity, vary during the peri-conceptional period (the 12 weeks around conception)? SUMMARY ANSWER: First morning urinary cortisol follows an overall increasing trajectory across the peri-conceptional period, interrupted by 2 week-long decreases during the week preceding conception and the fifth week following conception. WHAT IS KNOWN ALREADY: Later gestational stages (i...
June 2015: Human Reproduction
https://www.readbyqxmd.com/read/25801372/estimated-human-excretion-rates-of-natural-estrogens-calculated-from-their-concentrations-in-raw-municipal-wastewater-and-its-application
#12
Ze-Hua Liu, Gui-Ning Lu, Hua Yin, Zhi Dang
Natural estrogens are important endocrine disrupting compounds (EDCs), which may pose adverse effects on our environment. To avoid time-consuming sample preparation and chemical analysis, estimation of their concentrations in municipal wastewater based on their human urine/feces excretion rates has been generally adopted. However, the data of excretion rates available are very limited and show significant difference among countries. In the context of increasing reporting on the concentrations of natural estrogens in municipal wastewater around the world, this study presented a simple method to estimate their human excretion rates based on the concentrations of natural estrogens in raw sewage...
June 2015: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/25720077/development-of-the-first-urinary-reproductive-hormone-ranges-referenced-to-independently-determined-ovulation-day
#13
Sarah Johnson, Sarah Weddell, Sonya Godbert, Guenter Freundl, Judith Roos, Christian Gnoth
BACKGROUND: Urinary hormone level analysis provides valuable fertility status information; however, previous studies have not referenced levels to the ovulation day, or have used outdated methods. This study aimed to produce reproductive hormone ranges referenced to ovulation day determined by ultrasound. METHODS: Women aged 18-40 years (no reported infertility) collected daily urine samples for one complete menstrual cycle. Urinary luteinising hormone (LH), estrone-3-glucuronide (E3G, an estradiol metabolite), follicle stimulating hormone (FSH) and pregnanediol-3-glucuronide (P3G, a progesterone metabolite) were measured using previously validated assays...
June 2015: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/25498592/time-related-increase-in-urinary-testosterone-levels-and-stable-semen-analysis-parameters-after-bariatric-surgery-in-men
#14
Richard S Legro, Allen R Kunselman, Juliana W Meadows, James S Kesner, Edward F Krieg, Ann M Rogers, Robert N Cooney
The aim of this prospective cohort study was to determine the time-course in androgen and semen parameters in men after weight loss associated with bariatric surgery. Six men aged 18-40 years, meeting National Institutes of Health bariatric surgery guidelines, were followed between 2005 and 2008. Study visits took place at baseline, then 1, 3, 6 and 12 months after surgery. All men underwent Roux-en-y gastric bypass (RYGB). At each visit, biometric, questionnaire, serum, and urinary specimens and seman analysis were collected...
February 2015: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/25431744/associations-between-dietary-intake-of-fruits-and-vegetables-in-relation-to-urinary-estrogen-dna-adduct-ratio
#15
Kerryn W Reding, Muhammad Zahid, Ercole Cavalieri, Eleanor G Rogan, Brianne S Raccor, Charlotte Atkinson, Mellissa Yong, Katherine M Newton, Johanna W Lampe
BACKGROUND: Estrogen exposure plays a role in breast cancer (BC) development. A novel estrogen biomarker, the estrogen DNA adduct (EDA) ratio, was shown to be elevated in women at high-risk of BC and among BC cases. Modifiable factors may impact the EDA ratio, with studies demonstrating that resveratrol reduces EDA ratio in vitro. We sought to examine the hypothesis that dietary intake of fruits and vegetables is inversely associated with EDA ratio. METHODS: This analysis was conducted in 53 pre-menopausal, healthy women aged 40-45 years from a cross-sectional study in which participants provided first-void urine samples and 3-day food records...
June 2014: Open Journal of Preventive Medicine
https://www.readbyqxmd.com/read/25353669/reductions-in-urinary-collection-frequency-for-assessment-of-reproductive-hormones-provide-physiologically-representative-exposure-and-mean-concentrations-when-compared-with-daily-collection
#16
Heather C M Allaway, Nancy I Williams, Rebecca J Mallinson, Karsten Koehler, Mary Jane De Souza
OBJECTIVE: To determine if reducing the frequency of urinary sample collection from daily to 5, 3, or 2 days per week during a menstrual cycle or 28-day amenorrheic monitoring period provide accurate representations of the reproductive hormone metabolites estrone-1-glucuronide (E1G) and pregnanediol glucuronide (PdG) exposure and mean concentrations. METHODS: Exercising women presenting with eumenorrhea or exercise-associated menstrual disturbances collected daily urine samples for the assessment of E1G and PdG concentrations...
May 2015: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/25352438/magnitude-of-daily-energy-deficit-predicts-frequency-but-not-severity-of-menstrual-disturbances-associated-with-exercise-and-caloric-restriction
#17
RANDOMIZED CONTROLLED TRIAL
Nancy I Williams, Heather J Leidy, Brenna R Hill, Jay L Lieberman, Richard S Legro, Mary Jane De Souza
We assessed the impact of energy deficiency on menstrual function using controlled feeding and supervised exercise over four menstrual cycles (1 baseline and 3 intervention cycles) in untrained, eumenorrheic women aged 18-30 yr. Subjects were randomized to either an exercising control (EXCON) or one of three exercising energy deficit (ED) groups, i.e., mild (ED1; -8 ± 2%), moderate (ED2; -22 ± 3%), or severe (ED3; -42 ± 3%). Menstrual cycle length and changes in urinary concentrations of estrone-1-glucuronide, pregnanediol glucuronide, and midcycle luteinizing hormone were assessed...
January 1, 2015: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/25211668/associations-of-the-fecal-microbiome-with-urinary-estrogens-and-estrogen-metabolites-in-postmenopausal-women
#18
Barbara J Fuhrman, Heather Spencer Feigelson, Roberto Flores, Mitchell H Gail, Xia Xu, Jacques Ravel, James J Goedert
CONTEXT: The gut microbiota may influence the risk of breast cancer through effects on endogenous estrogens. OBJECTIVE: The objective of the study was to investigate whether urinary estrogens and estrogen metabolites are associated with the diversity and composition of the fecal microbiome. DESIGN AND SETTING: This was a cross-sectional study among women enrolled in Kaiser Permanente of Colorado. PARTICIPANTS: A total of 60 women drawn from a random sample of healthy postmenopausal women (aged 55-69 y), without current or recent use of antibiotics or hormone therapy and no history of cancer or gastrointestinal disease participated in the study...
December 2014: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/25115686/a-pilot-clinical-study-of-resveratrol-in-postmenopausal-women-with-high-body-mass-index-effects-on-systemic-sex-steroid-hormones
#19
H-H Sherry Chow, Linda L Garland, Brandy M Heckman-Stoddard, Chiu-Hsieh Hsu, Valerie D Butler, Catherine A Cordova, Wade M Chew, Terri L Cornelison
BACKGROUND: Breast cancer risk is partially determined by several hormone-related factors. Preclinical and clinical studies suggested that resveratrol may modulate these hormonal factors. METHODS: We conducted a pilot study in postmenopausal women with high body mass index (BMI ≥ 25 kg/m2) to determine the clinical effect of resveratrol on systemic sex steroid hormones. Forty subjects initiated the resveratrol intervention (1 gm daily for 12 weeks) with six withdrawn early due to adverse events (AEs)...
August 14, 2014: Journal of Translational Medicine
https://www.readbyqxmd.com/read/24887515/genetic-variation-at-cyp3a-is-associated-with-age-at-menarche-and-breast-cancer-risk-a-case-control-study
#20
Nichola Johnson, Frank Dudbridge, Nick Orr, Lorna Gibson, Michael E Jones, Minouk J Schoemaker, Elizabeth J Folkerd, Ben P Haynes, John L Hopper, Melissa C Southey, Gillian S Dite, Carmel Apicella, Marjanka K Schmidt, Annegien Broeks, Laura J Van't Veer, Femke Atsma, Kenneth Muir, Artitaya Lophatananon, Peter A Fasching, Matthias W Beckmann, Arif B Ekici, Stefan P Renner, Elinor Sawyer, Ian Tomlinson, Michael Kerin, Nicola Miller, Barbara Burwinkel, Frederik Marme, Andreas Schneeweiss, Christof Sohn, Pascal Guénel, Therese Truong, Emilie Cordina, Florence Menegaux, Stig E Bojesen, Børge G Nordestgaard, Henrik Flyger, Roger Milne, M Pilar Zamora, Jose Ignacio Arias Perez, Javier Benitez, Leslie Bernstein, Hoda Anton-Culver, Argyrios Ziogas, Christina Clarke Dur, Hermann Brenner, Heiko Müller, Volker Arndt, Aida Karina Dieffenbach, Alfons Meindl, Joerg Heil, Claus R Bartram, Rita K Schmutzler, Hiltrud Brauch, Christina Justenhoven, Yon-Dschun Ko, Heli Nevanlinna, Taru A Muranen, Kristiina Aittomäki, Carl Blomqvist, Keitaro Matsuo, Thilo Dörk, Natalia V Bogdanova, Natalia N Antonenkova, Annika Lindblom, Arto Mannermaa, Vesa Kataja, Veli-Matti Kosma, Jaana M Hartikainen, Georgia Chenevix-Trench, Jonathan Beesley, Anna H Wu, David Van den Berg, Chiu-Chen Tseng, Diether Lambrechts, Dominiek Smeets, Patrick Neven, Hans Wildiers, Jenny Chang-Claude, Anja Rudolph, Stefan Nickels, Dieter Flesch-Janys, Paolo Radice, Paolo Peterlongo, Bernardo Bonanni, Valeria Pensotti, Fergus J Couch, Janet E Olson, Xianshu Wang, Zachary Fredericksen, Vernon S Pankratz, Graham G Giles, Gianluca Severi, Laura Baglietto, Chris Haiman, Jacques Simard, Mark S Goldberg, France Labrèche, Martine Dumont, Penny Soucy, Soo Teo, Cheng Har Yip, Sze Yee Phuah, Belinda K Cornes, Vessela N Kristensen, Grethe Grenaker Alnæs, Anne-Lise Børresen-Dale, Wei Zheng, Robert Winqvist, Katri Pylkäs, Arja Jukkola-Vuorinen, Mervi Grip, Irene L Andrulis, Julia A Knight, Gord Glendon, Anna Marie Mulligan, Peter Devillee, Jonine Figueroa, Stephen J Chanock, Jolanta Lissowska, Mark E Sherman, Per Hall, Nils Schoof, Maartje Hooning, Antoinette Hollestelle, Rogier A Oldenburg, Madeleine Tilanus-Linthorst, Jianjun Liu, Angie Cox, Ian W Brock, Malcolm W R Reed, Simon S Cross, William Blot, Lisa B Signorello, Paul D P Pharoah, Alison M Dunning, Mitul Shah, Daehee Kang, Dong-Young Noh, Sue K Park, Ji-Yeob Choi, Mikael Hartman, Hui Miao, Wei Yen Lim, Anthony Tang, Ute Hamann, Asta Försti, Thomas Rüdiger, Hans Ulrich Ulmer, Anna Jakubowska, Jan Lubinski, Katarzyna Jaworska-Bieniek, Katarzyna Durda, Suleeporn Sangrajrang, Valerie Gaborieau, Paul Brennan, James McKay, Susan Slager, Amanda E Toland, Celine Vachon, Drakoulis Yannoukakos, Chen-Yang Shen, Jyh-Cherng Yu, Chiun-Sheng Huang, Ming-Feng Hou, Anna González-Neira, Daniel C Tessier, Daniel Vincent, Francois Bacot, Craig Luccarini, Joe Dennis, Kyriaki Michailidou, Manjeet K Bolla, Jean Wang, Douglas F Easton, Montserrat García-Closas, Mitch Dowsett, Alan Ashworth, Anthony J Swerdlow, Julian Peto, Isabel dos Santos Silva, Olivia Fletcher
INTRODUCTION: We have previously shown that a tag single nucleotide polymorphism (rs10235235), which maps to the CYP3A locus (7q22.1), was associated with a reduction in premenopausal urinary estrone glucuronide levels and a modest reduction in risk of breast cancer in women age ≤50 years. METHODS: We further investigated the association of rs10235235 with breast cancer risk in a large case control study of 47,346 cases and 47,570 controls from 52 studies participating in the Breast Cancer Association Consortium...
May 26, 2014: Breast Cancer Research: BCR
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