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Dermatology skin diseases

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https://www.readbyqxmd.com/read/29333029/flagellate-rash-an-unusual-complication-of-bleomycin-therapy-a-case-report-with-brief-review-of-literature
#1
Chaturbhuj Agrawal, Vineet Talwar, Rajeev Saini, Pradeep Babu
Chemotherapy-induced skin rashes are common toxicities encountered which require careful assessment and evaluation as rashes could be a manifestation of primary malignancy itself and a variety of drugs used in combination further complicate the clinical scenario. Bleomycin is an anticancer antibiotic derived from Streptomyces verticillus and has been commonly used in the treatment of Hodgkin's disease, germ cell tumors and for pleurodesis. There are various dermatological adverse effects of bleomycin which have been previously reported in literature including skin peeling, hyperkeratosis, nail bed changes, Raynaud's phenomenon, and palmoplantar desquamation...
October 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/29322178/early-genetic-diagnosis-of-neurofibromatosis-type-2-from-skin-plaque-plexiform-schwannomas-in-childhood
#2
Elisabeth Castellanos, Adrià Plana, Cristina Carrato, Meritxell Carrió, Inma Rosas, Emilio Amilibia, Francesc Roca-Ribas, Cristina Hostalot, Alicia Castillo, Andrea Ros, Ariadna Quer, Juan Luis Becerra, Hector Salvador, Conxi Lázaro, Ignacio Blanco, Eduard Serra, Isabel Bielsa
Importance: Neurofibromatosis type 2 (NF2) is a devastating genetic condition characterized by the development of multiple tumors of the nervous system. An early diagnosis of individuals with NF2 would facilitate treatment and reduction of disease impact because most severe effects of the disease do not usually develop before adolescence. Little attention has traditionally been paid to dermatological signs in NF2. However, skin plaques are commonly seen in patients with NF2, normally appearing either at birth or early childhood, providing an opportunity for early NF2 detection and testing...
January 10, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29315491/health-related-quality-of-life-in-adolescents-with-psoriasis-an-interview-based-study
#3
H Randa, J J Lomholt, L Skov, R Zachariae
BACKGROUND: Psoriasis is a common skin disease affecting the physical, psychological and social well-being of patients and their families. Most research so far has been limited to adults, and little is known about the qualitative experiences of young people with psoriasis. OBJECTIVES: To provide an in-depth understanding of the impact of psoriasis on adolescents' Health-Related Quality of Life (HRQoL). METHODS: Patients and their parents were recruited from a dermatology outpatient clinic, the Danish National Birth Cohort, and the Danish Psoriasis Association...
January 8, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29315147/nonmelanoma-skin-cancer-risk-in-patients-with-inflammatory-bowel-disease-undergoing-thiopurine-therapy-a-systematic-review-of-the-literature
#4
Joshua W Hagen, Melissa A Pugliano-Mauro
BACKGROUND: Azathioprine and 6-mercaptopurine (thiopurines) are common adjunct treatments for inflammatory bowel disease (IBD). Although thiopurine therapy in organ transplant recipients is known to increase nonmelanoma skin cancers (NMSCs), dermatologic literature yields less data regarding NMSC risk of thiopurine use in IBD. OBJECTIVE: The aim of this study was to systematically review current literature on NMSC risk in patients with IBD using thiopurine therapy...
January 8, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29314351/epidemiology-of-dermatophyte-infections-among-school-children-in-menoufia-governorate-egypt
#5
Azza G A Farag, Mostafa A Hammam, Reda A Ibrahim, Reda Z Mahfouz, Nada F Elnaidany, Masroor Qutubuddin, Rehab R E Tolba
BACKGROUND: Most superficial mycotic infections of human skin are due to dermatophytes. Children are frequently affected due to different predisposing factors, particularly overcrowding in classrooms. OBJECTIVES: To estimate the prevalence of dermatophytes infections and their related risk factors among school children in Menoufia Governorate, Egypt. SUBJECTS AND METHODS: Six public primary and preparatory schools were randomly selected and their pupils (n= 3464) were asked to complete a predesigned questionnaire covering both personal data and suspected risk factors for superficial dermatophyte infections...
January 4, 2018: Mycoses
https://www.readbyqxmd.com/read/29309411/tungiasis-related-life-quality-impairment-in-children-living-in-rural-kenya
#6
Susanne Wiese, Lynne Elson, Hermann Feldmeier
BACKGROUND: Tungiasis (sand flea disease) is a neglected tropical skin disease caused by female sand fleas (Tunga spp.) embedded in the skin of the host. The disease is common in sub-Saharan Africa and predominantly affects children living in impoverished rural communities. In these settings tungiasis is associated with important morbidity. Whether tungiasis impairs life quality has never been studied. METHODS: The study was performed in 50 children with tungiasis, living in resource-poor communities in coastal Kenya...
January 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29308771/clinical-features-and-prognostic-factors-of-cutaneous-vasculitis-among-dermatology-patients-in-johor-bahru-malaysia
#7
S Latha, S E Choon, K E Tey, Y N Chee
BACKGROUND: Cutaneous vasculitis is common, yet the risk factors for its chronicity have not been established. OBJECTIVE: To describe the clinical spectrum and identify risk factors for chronicity of cutaneous vasculitis. METHODS: Retrospective data analysis of 275 patients diagnosed with cutaneous vasculitis from January 2008 to December 2013. RESULTS: The mean age was 33.7 (±17.89) years, with female predominance...
December 2017: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/29305750/visual-symptom-provocation-in-skin-picking-disorder-an-fmri-study
#8
Anne Schienle, Sonja Übel, Albert Wabnegger
Skin-picking disorder (SPD) is a common mental disorder characterized by recurrent and excessive picking of dermatological irregularities. Different disorder models have been developed to explain this behavior, but empirical evidence is still scarce. One model (the disgust-related disease avoidance model) suggests that SPD might be understood as pathological grooming elicited by skin imperfections that singal possible infection. Twenty-five women with SPD and 19 matched controls viewed and rated images depicting skin irregularities and smooth skin during functional magnetic resonance imaging...
January 5, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29304933/comparison-of-adalimumab-and-etanercept-for-the-treatment-of-moderate-to-severe-psoriasis-an-indirect-comparison-using-individual-patient-data-from-randomized-trials
#9
Kim A Papp, Min Yang, Murali Sundaram, John Jarvis, Keith A Betts, Yanjun Bao, James E Signorovitch
OBJECTIVES: To compare outcomes between adalimumab and etanercept in the treatment of moderate to severe plaque psoriasis. METHODS: Study groups included patients randomized to adalimumab or placebo (REVEAL and CHAMPION trials) and those randomized to etanercept or placebo (M10-114 and M10-315 trials). Week 12 outcomes were compared between patients receiving adalimumab and those receiving etanercept after adjusting for cross-trial differences in patient characteristics using propensity score weighting and after subtracting effects of placebo...
January 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29300856/cutaneous-morbidity-among-inflammatory-bowel-disease-patients-a-cohort-study
#10
Júlia Vide, Filipa Osório, Miguel Costa-Silva, Sofia Lopes, Filomena Azevedo, Cláudia Camila Dias, Sofia Magina, Fernando Magro
Background and aims: Patients afflicted with inflammatory bowel diseases are prone to have cutaneous manifestations. The aim of this study was to investigate their prevalence, type and association to demographic and clinical-related factors. Methods: This was a cross-sectional study. Information relative to patients of a central Portuguese hospital with a definitive diagnosis of an inflammatory bowel disease, who were prospectively recruited, was collected. Results: The final cohort included 342 patients, of whom 62% had Crohn´s disease and 38% had ulcerative colitis...
December 28, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29298167/newly-developed-skin-picking-after-methylphenidate-treatment-in-attention-deficit-hyperactivity-disorder-possible-mechanisms
#11
Tayfun Kara, İsmail Akaltun
Dermatillomania is characterized by excessive and repeated skin picking sufficient to damage cutaneous tissue, but with no underlying dermatological disease. The condition appears as an independent diagnosis in the Obsessive-Compulsive and Related Disorders category in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. A psychiatric pathology is generally reported to accompany this symptom. Attention deficit hyperactivity disorder (ADHD) is a potentially lifelong condition involving inattentiveness, hyperactivity, and impulsiveness...
January 2, 2018: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/29283443/letter-on-european-dermatology-forum-s1-guideline-on-the-diagnosis-and-treatment-of-sclerosing-diseases-of-the-skin-part-2-scleromyxedema-scleredema-and-nephrogenic-systemic-fibrosis
#12
Patrick Mark, Ilona Dekkers, Peter Blankestijn, Tim Leiner, Giles Roditi
We read with interest the guidelines recently published on sclerosing diseases of the skin (Part 2: Scleromyxedema, scleredema and nephrogenic systemic fibrosis)[1, 2]. However, we are concerned that the guideline recommendations proposed for prevention of nephrogenic systemic fibrosis (NSF) are potentially dangerous. Although we recognise the challenges in constructing comprehensive guidelines, we are concerned that this may be because the guidelines have not involved a multidisciplinary team. This article is protected by copyright...
December 28, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29279287/histone-modifiers-dynamic-regulators-of-the-cutaneous-transcriptome
#13
Kanad Ghosh, Kyle O'Neil, Brian C Capell
By regulating the accessibility of the genome, epigenetic regulators such as histone proteins and the chromatin-modifying enzymes that act upon them control gene expression. Proper regulation of this "histone code" allows for the precise control of transcriptional networks that are essential for establishing and maintaining cell fate and identity, disruption of which may drive carcinogenesis. How these dynamic epigenetic regulators contribute to both skin homeostasis and disease is only beginning to be understood...
December 18, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29275076/dermatological-manifestations-in-onchocerciasis-a-retrospective-study-of-400-imported-cases
#14
Sabino Puente, German Ramirez-Olivencia, Mar Lago, Mercedes Subirats, Eugenio Perez-Blazquez, Fernando Bru, Teresa Garate, Belén Vicente, Moncef Belhassen-Garcia, Antonio Muro
INTRODUCTION: Onchocerciasis is caused by Onchocerca volvulus and mainly leads to pruritus and skin and visual disorders, including blindness. Seventeen million people are infected in 38 countries; 31 of these are in sub-Saharan Africa, six in Latin America and one on the Arabian Peninsula. More than 99% of cases occur in sub-Saharan Africa where 120 million people are at risk of infection. Eye disorders have been well-documented; however, skin disorders have not been described accurately...
December 20, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/29273489/inflammatory-dermatoses-infections-and-drug-eruptions-are-the-most-common-skin-conditions-in-hospitalized-cancer-patients
#15
Gregory S Phillips, Azael Freites-Martinez, Meier Hsu, Anna Skripnik Lucas, Dulce M Barrios, Kathryn Ciccolini, Michael A Marchetti, Liang Deng, Patricia L Myskowski, Erica H Lee, Alina Markova, Mario E Lacouture
BACKGROUND: Dermatologic conditions cause morbidity and mortality among hospitalized cancer patients. An improved understanding is critical for implementing clinical and research programs in inpatient oncodermatology. OBJECTIVE: To characterize inpatient dermatology consultations at a large comprehensive cancer center. METHODS: Retrospective database query of new admissions and medical record review of initial inpatient dermatology consultations comparing consulted inpatients with non-consulted inpatients from January-December 2015...
December 19, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29259625/prevalence-and-factors-associated-with-self-medication-in-dermatology-in-togo
#16
Koussake Kombaté, Julienne Noude Técléssou, Bayaki Saka, Abla Sefako Akakpo, Koudjouka Odette Tchangai, Abas Mouhari-Toure, Garba Mahamadou, Waguena Gnassingbé, Aurel Abilogun-Chokki, Palokinam Pitché
Objective: This study aimed to determine the prevalence of and factors associated with self-medication in dermatology in Lomé, Togo. Methods: We conducted an analytical cross-sectional study from February to April 2016 in 2 dermatology departments in Lomé. Univariate and multivariate logistic regression models were carried out to identify possible factors associated with self-medication. Results: A total of 711 patients were included in the study...
2017: Dermatology Research and Practice
https://www.readbyqxmd.com/read/29258952/5-aminolevulinic-acid-photodynamic-therapy-in-refractory-vulvar-lichen-sclerosus-et-atrophicus-series-of-ten-cases
#17
Ting Lan, Yongzhen Zou, Michael R Hamblin, Rui Yin
BACKGROUND: Vulvar lichen sclerosus et atrophicus (VLSA) is a chronic inflammatory skin disease of unknown etiology that mainly affects postmenopausal and perimenopausal women. The primary clinical symptoms of VLSA are itching, burning pain, and dyspareunia that can results in decreased quality of life. Existing therapies including topical corticosteroid ointment, topical calcineurin inhibitors, estrogens, are not very effective for treatment of VLSA. OBJECTIVE: To evaluate the effectiveness and safety of 5-aminolevulinic acid mediated photodynamic therapy (ALA-PDT) in the treatment of VLSA...
December 16, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29249119/expression-of-mirna-155-foxp3-and-ror-gamma-in-children-with-moderate-and-severe-atopic-dermatitis
#18
Massimiliano Bergallo, Martina Accorinti, Ilaria Galliano, Paola Coppo, Paola Montanari, Pietro Quaglino, Francesco Savino
BACKGROUND: Atopic dermatitis is a disease characterized by a chronic inflammatory process in the skin, but its link to miRNA 155 is less known. The aim of the study was to evaluate the expression of microRNA155, and T helper type 17 cells and Treg cells in children with atopic dermatitis. METHODS: The study population consisted of: children seen for atopic dermatitis at the outpatient ambulatory of Dermatology at the Children Hospital Regina Margherita, Torino, Italy,( n = 23); healthy control subjects ( n =23)...
December 15, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29247454/dermatologists-across-europe-underestimate-depression-and-anxiety-results-from-3635-dermatological-consultations
#19
F J Dalgard, Å Svensson, U Gieler, L Tomas-Aragones, L Lien, F Poot, G B E Jemec, L Misery, C Szabo, D Linder, F Sampogna, A W M Evers, J Anders Halvorsen, F Balieva, J Szepietowski, A Lvov, S E Marron, I K Alturnay, A Y Finlay, S S Salek, J Kupfer
BACKGROUND: It was recently demonstrated that a significant number of patients with common skin diseases across Europe are clinically depressed and anxious. Studies have shown that physicians not trained as psychiatrist underdiagnose depression. This has not been explored among dermatologists. OBJECTIVES: To estimate the concordance between clinical assessment of depression and anxiety by a dermatologist and assessment with the Hospital Anxiety and Depression Scale...
December 16, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29243825/dermatologic-manifestations-among-human-immunodeficiency-virus-patients-in-morocco-and-association-with-immune-status
#20
Hicham Titou, Christelle Ebongo, Naoufal Hjira
OBJECTIVE: The objective was to determine if the type and number of skin diseases can be clinical indicators of underlying immune status in HIV1 disease by estimating and correlating with the CD4 count and CDC stage. MATERIALS AND METHODS: This was a retrospective cross-sectional descriptive study. All consecutive patients infected with HIV1 followed at the Dermatology Department of Rabat Military Hospital between January 2008 and January 2017 were studied for dermatological manifestations, CD4 count and CDC clinical stage...
December 15, 2017: International Journal of Dermatology
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