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Dermatology skin diseases

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https://www.readbyqxmd.com/read/29774138/clinical-evaluation-of-morgellons-disease-in-a-cohort-of-north-american-patients
#1
Melissa C Fesler, Marianne J Middelveen, Raphael B Stricker
Morgellons disease (MD) is a dermatological condition characterized by aberrant production of keratin and collagen fibers in skin. Although infection with Borrelia burgdorferi , the causative agent of Lyme disease (LD), has been associated with MD, relatively few studies have hitherto provided epidemiological evidence regarding this association. A cohort of 1000 seropositive North American LD patients was evaluated for the presence of MD. Patients were diagnosed with MD based on detection of microscopic fibers in skin lesions or under unbroken skin...
April 23, 2018: Dermatology Reports
https://www.readbyqxmd.com/read/29773231/biologics-in-sapho-syndrome-a-systematic-review
#2
REVIEW
Dimitrios Daoussis, Georgia Konstantopoulou, Pantelis Kraniotis, Lazaros Sakkas, Stamatis-Nick Liossis
BACKGROUND: The SAPHO syndrome is a relatively rare clinical entity characterized by a wide range of dermatological and musculoskeletal manifestations. Biologics have been used in cases refractory to conventional treatment. METHODS: We present herein a patient with refractory to treatment SAPHO syndrome who exhibited a dramatic and fast response to IL-17 blockade. Additionally, we performed a systematic review of all cases of patients with SAPHO syndrome treated with biologics to date...
April 17, 2018: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29770722/patients-preferences-for-different-corticosteroid-vehicles-are-highly-variable
#3
Kayla Felix, Emily Unrue, Meyene Inyang, Leah A Cardwell, Elias Oussedik, Irma Richardson, Steven R Feldman
INTRODUCTION: Topical corticosteroids, available in an array of vehicles are used to control a variety of inflammatory skin diseases. Patients' preferences for different vehicles may affect their willingness to use treatment. We assess corticosteroid vehicle preference and potential impact of topical characteristics on adherence and quality of life in patients with psoriasis. METHODS: Subjects with psoriasis were recruited from Wake Forest University Dermatology Clinic...
May 17, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29768078/wet-wrap-therapy-with-halometasone-cream-for-severe-adult-atopic-dermatitis
#4
Wei Xu, Yan Li, Zeyu Chen, Teng Liu, Shan Wang, Linfeng Li
BACKGROUND: Currently there is no cure for severe atopic dermatitis (AD). Wet-wrap therapy (WWT) has also been used to treat pediatric AD and shown a satisfactory effectiveness, but clinical evidence supporting the use of WWT on severe adult AD is still insufficient. METHODS: Twelve patients (8 men and 4 women) with severe AD (SCORing Atopic Dermatitis [SCORAD] score≥50) treated between January 2015 and September 2017 in our hospital were included. The patients underwent WWT (daily dose: 15g halometasone cream+100g Vaseline ointment) twice daily for 2 hours/session for 7 days...
May 16, 2018: Postgraduate Medicine
https://www.readbyqxmd.com/read/29766690/garden-nasturtium-tropaeolum-majus-l-a-source-of-mineral-elements-and-bioactive-compounds
#5
Karolina Jakubczyk, Katarzyna Janda, Katarzyna Watychowicz, Jagoda Łukasiak, Jolanta Wolska
The garden nasturtium (Tropaeolum majus L.) belongs to the family Tropaeolaceae. Native to South America it was brought to Europe in XVI century. It is a plant with numerous healing properties. Medicinal plants such as the garden nasturtium contain trace elements and bioactive compounds which can be easily absorbed by the human body. The flowers and other parts of the garden nasturtium are a good source of micro elements such as potassium, phosphorus, calcium and magnesium, and macro elements, especially of zinc, copper and iron...
2018: Roczniki Państwowego Zakładu Higieny
https://www.readbyqxmd.com/read/29766488/nanoemulsions-and-dermatological-diseases-contributions-and-therapeutic-advances
#6
REVIEW
Myla Lôbo de Souza, Douglas Dourado Oliveira, Neila de Paula Pereira, Denis Melo Soares
Skin disease is one of the most common human diseases and affects between 30% and 70% of individuals, which requires a lot of attention to their treatments. The delivery of active pharmacological ingredients at the topical level is a challenge because of the difficulties in overcoming the mechanical barrier created by the skin and reaching greater depths, since delivery specificities are decisive for the degree of effectiveness. In this way, the nanoemulsions emerge as a potential system for the incorporation of active substances in the cells and for the controlled release of active principles...
May 15, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29761532/dermatological-aspects-of-tularaemia-a-study-of-168-cases
#7
M Polat, T Karapınar, F Sırmatel
BACKGROUND: Tularaemia is a zoonotic infectious disease caused by Francisella tularensis, an aerobic, uncapsulated, gram-negative coccobacillus. Several case reports have appeared on the dermatological manifestations of tularaemia, but relatively few longer-term studies are available. AIM: To identify skin features of tularaemia that aid in its diagnosis. METHODS: In total, 168 patients (68 male, 100 female) diagnosed with tularaemia were retrospectively examined...
May 14, 2018: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29760984/the-value-of-ultrahigh-resolution-oct-in-dermatology-delineating-the-dermo-epidermal-junction-capillaries-in-the-dermal-papillae-and-vellus-hairs
#8
Niels Møller Israelsen, Michael Maria, Mette Mogensen, Sophie Bojesen, Mikkel Jensen, Merete Haedersdal, Adrian Podoleanu, Ole Bang
Optical coherence tomography (OCT) imaging of the skin is gaining recognition and is increasingly applied to dermatological research. A key dermatological parameter inferred from an OCT image is the epidermal (Ep) thickness as a thickened Ep can be an indicator of a skin disease. Agreement in the literature on the signal characters of Ep and the subjacent skin layer, the dermis (D), is evident. Ambiguities of the OCT signal interpretation in the literature is however seen for the transition region between the Ep and D, which from histology is known as the dermo-epidermal junction (DEJ); a distinct junction comprised of the lower surface of a single cell layer in epidermis (the stratum basale) connected to an even thinner membrane (the basement membrane)...
May 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/29760622/skin-and-mucous-membranes-manifestations-of-dermatological-diseases-within-the-genital-area-in-females
#9
Katarzyna Plagens-Rotman, Renata Przybylska, Zygmunt Adamski, Magdalena Czarnecka-Operacz
Introduction: Lichen sclerosus et atrophicus (LSA) and an inversed type of psoriasis belong to a group of benign dermatoses usually located within the region of female external genitalia. The most common subjective symptoms reported by patients are itching, pain and changes in the color and structure of the skin. Aim: This paper presents 3 cases of patients suffering from selected dermatoses located within the external female genitalia treated at the Department of Dermatology, Poznan University of Medical Sciences...
April 2018: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/29760618/-demodex-spp-as-a-possible-aetiopathogenic-factor-of-acne-and-relation-with-acne-severity-and-type
#10
Ulviye Güvendi Akçınar, Emine Ünal, Funda Doğruman Al
Introduction: Acne is a very common skin disease in adolescents and young adults, but it also affects adults. However, its aetiology is not yet fully understood. Demodex appears to be associated with multiple skin disorders, but controversy persists. Some reports indicate a connection between acne vulgaris and demodicosis. Aim: To confirm the association between Demodex infestation and acne vulgaris. Material and methods: A total of 108 patients were enrolled in the acne group...
April 2018: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/29758553/a-retrospective-cohort-study-on-patients-with-hidradenitis-suppurativa
#11
S Morteza Seyed Jafari, Evelyne Knüsel, Simone Cazzaniga, Robert E Hunger
BACKGROUND: Hidradenitis suppurativa (HS) is one of the most distressing conditions observed in dermatology and has a substantial negative effect on the quality of life of affected persons. OBJECTIVES: The aim of this study was to evaluate different treatment strategies in patients with HS. METHODS: In a retrospective cohort, all patients with HS (July 2015 to March 2017) were reviewed. Collected data consisted of patients' demographics, clinical characteristics, psychosocial situation, and previous and current treatments...
May 14, 2018: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/29750172/proanthocyanidins-against-oxidative-stress-from-molecular-mechanisms-to-clinical-applications
#12
REVIEW
Lingyu Yang, Dehai Xian, Xia Xiong, Rui Lai, Jing Song, Jianqiao Zhong
Proanthocyanidins (PCs) are naturally occurring polyphenolic compounds abundant in many vegetables, plant skins (rind/bark), seeds, flowers, fruits, and nuts. Numerous in vitro and in vivo studies have demonstrated myriad effects potentially beneficial to human health, such as antioxidation, anti-inflammation, immunomodulation, DNA repair, and antitumor activity. Accumulation of prooxidants such as reactive oxygen species (ROS) exceeding cellular antioxidant capacity results in oxidative stress (OS), which can damage macromolecules (DNA, lipids, and proteins), organelles (membranes and mitochondria), and whole tissues...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29744872/profound-consequences-of-hidradenitis-suppurativa-a-review
#13
REVIEW
Ł Matusiak
Hidradenitis suppurativa (HS) influences patients' lives in many ways. The most troublesome symptom of HS is chronic pain, of mild-to-moderate intensity, which is reported by almost all patients. With reference to psychosocial evaluation, HS appears to be a highly debilitating disease. The major factors influencing patients' well-being are disease severity, the number of flares or affected skin areas, and the lesion location. The mean Dermatology Life Quality Index scores of 8·3-12·7 points obtained among patients with HS are typical for severe dermatoses, which have a large impact on patients' quality of life (QoL)...
May 9, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29742056/a-dermatologic-perspective-on-autoinflammatory-diseases
#14
REVIEW
Angelo Valerio Marzano, Giovanni Damiani, Giovanni Genovese, Marco Gattorno
Autoinflammatory diseases (AIDs) encompass a heterogeneous group of disorders pathogenetically related to an abnormal activation of the innate immunity and clinically characterised by aseptic inflammation in the affected organs in the absence of high titer of circulating autoantibodies or autoreactive T cells. In classic monogenic AIDs, the skin is frequently involved with a wide range of cutaneous lesions. Monogenic AIDs result from different mutations in a single gene, which regulates the innate immunity...
January 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29737215/needle-free-cutaneous-delivery-of-living-human-cells-by-er-yag-fractional-laser-ablation
#15
Jing Yu, Sachin Dubey, Yogeshvar N Kalia
BACKGROUND: Dermatological diseases, including most skin cancers and rare genetic conditions frequently originate in the epidermis. Targeted, topical cell-based therapy is a promising therapeutic strategy. Here, we present the first report demonstrating that fractional laser ablation enables local "needle-free" intraepidermal delivery of living human cells. METHODS: The cells penetrated porcine ear skin via microchannels created by Er:YAG fractional laser ablation; cell delivery was quantified using a haemocytometer...
May 8, 2018: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/29729180/the-widespread-use-of-topical-antimicrobials-enriches-for-resistance-in-staphylococcus-aureus-isolated-from-atopic-dermatitis-patients
#16
C P Harkins, M A McAleer, D Bennett, M McHugh, O M Fleury, K A Pettigrew, K Oravcová, J Parkhill, C M Proby, R S Dawe, J A Geoghegan, A D Irvine, M T G Holden
BACKGROUND: Carriage rates of Staphylococcus aureus on affected skin in atopic dermatitis (AD) are approximately 70%. Increasing disease severity during flares and overall disease severity correlate with increased burden of S. aureus. Treatment in AD therefore often targets S. aureus, with topical and systemic antimicrobials. OBJECTIVES: To determine if antimicrobial sensitivities and genetic determinants of resistance differed in S. aureus isolates from the skin of children with AD compared with healthy child nasal carriers...
May 5, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29726727/epigenetic-therapy-and-dermatologic-disease-moving-beyond-ctcl
#17
Joshua S Mervis, Jean S McGee
The epigenetic regulation of gene expression is accomplished primarily through DNA methylation, histone modification, and gene silencing via the action of microRNAs. While previously very difficult to study, the field of epigenetics has been greatly facilitated by recent technological innovations. Alterations in the epigenome and epigenetic machinery are now known to be present in a variety of diseases, most notably cancers. Moreover, evidence has emerged that epigenetic dysregulation plays a causative role in disease pathogenesis...
May 4, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29721626/-individual-prevention-of-occupational-contact-dermatitis-protective-gloves-and-skin-protection-recommendations-as-part-of-the-patient-management-scheme-by-the-public-statutory-employers-liability-insurance
#18
REVIEW
A Wilke, C Skudlik, F K Sonsmann
The dermatologist's procedure is a pivotal tool for early recognition of occupational contact dermatitis (OCD), for reporting OCD cases to the statutory accident insurance and for treating the diseases. The employer is in charge of implementing skin protection measures at the workplace. However, in terms of an individual prevention approach it may be necessary to propose targeted skin protection recommendations in specific patient cases. The patient's own skin protection behavior significantly contributes to regenerating and maintaining healthy skin...
May 2, 2018: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/29719009/skin-disease-education-foundation-s-42nd-annual-hawaii-dermatology-seminar%C3%A2-scientific-abstracts
#19
(no author information available yet)
No abstract text is available yet for this article.
June 2018: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29718343/dermatological-manifestations-in-pediatric-patients-with-inflammatory-bowel-diseases-on-anti-tnf-therapy
#20
Shilpa Sridhar, Ross M Maltz, Brendan Boyle, Sandra C Kim
Background: Anti-tumor necrosis factor (anti-TNF) therapies are effective treatments for inflammatory bowel diseases (IBD). However, infections, psoriasis, and eczema are potential manifestations. Descriptions of these are limited. Our aim was to characterize these skin manifestations in children with IBD on anti-TNF therapy. Methods: Our study is a retrospective review of IBD patients ranging in age from 6 to 18 years who were treated with anti-TNFs from 2010-2015...
April 27, 2018: Inflammatory Bowel Diseases
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