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Biomimicry

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https://www.readbyqxmd.com/read/27901298/biomimicry-promotes-the-efficiency-of-a-10-step-sequential-enzymatic-reaction-on-nanoparticles-converting-glucose-to-lactate
#1
Chinatsu Mukai, Lizeng Gao, Jacquelyn L Nelson, James P Lata, Roy Cohen, Lauren Wu, Meleana M Hinchman, Magnus Bergkvist, Robert W Sherwood, Sheng Zhang, Alexander J Travis
For nanobiotechnology to achieve its potential, complex organic-inorganic systems must grow to utilize the sequential functions of multiple biological components. Critical challenges exist: immobilizing enzymes can block substrate-binding sites or prohibit conformational changes, substrate composition can interfere with activity, and multistep reactions risk diffusion of intermediates. As a result, the most complex tethered reaction reported involves only 3 enzymes. Inspired by the oriented immobilization of glycolytic enzymes on the fibrous sheath of mammalian sperm, here we show a complex reaction of 10 enzymes tethered to nanoparticles...
November 30, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27706880/genetic-algorithm-based-optimization-of-a-peptidic-scaffold-for-sequestration-and-hydration-of-co2
#2
Elizabeth Brunk, Marta A S Perez, Prashanth Athri, Ursula Rothlisberger
Biomimicry is a strategy that makes practical use of evolution to find efficient and sustainable ways to produce chemical compounds or engineer products. Exploring the natural machinery of enzymes for the production of desired compounds is a highly profitable investment, but the design of efficient biomimetic systems remains a considerable challenge. An ideal biomimetic system self-assembles in solution, binds a desired range of substrates and catalyzes reactions with turnover rates similar to the native system...
December 5, 2016: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/27704794/influence-of-ligand-architecture-in-tuning-reaction-bifurcation-pathways-for-chlorite-oxidation-by-non-heme-iron-complexes
#3
Prasenjit Barman, Abayomi S Faponle, Anil Kumar Vardhaman, Davide Angelone, Anna-Maria Löhr, Wesley R Browne, Peter Comba, Chivukula V Sastri, Sam P de Visser
Reaction bifurcation processes are often encountered in the oxidation of substrates by enzymes and generally lead to a mixture of products. One particular bifurcation process that is common in biology relates to electron transfer versus oxygen atom transfer by high-valent iron(IV)-oxo complexes, which nature uses for the oxidation of metabolites and drugs. In biomimicry and bioremediation, an important reaction relates to the detoxification of ClOx(-) in water, which can lead to a mixture of products through bifurcated reactions...
October 5, 2016: Inorganic Chemistry
https://www.readbyqxmd.com/read/27703233/biomimetic-carriers-mimicking-leukocyte-plasma-membrane-to-increase-tumor-vasculature-permeability
#4
R Palomba, A Parodi, M Evangelopoulos, S Acciardo, C Corbo, E de Rosa, I K Yazdi, S Scaria, R Molinaro, N E Toledano Furman, J You, M Ferrari, F Salvatore, E Tasciotti
Recent advances in the field of nanomedicine have demonstrated that biomimicry can further improve targeting properties of current nanotechnologies while simultaneously enable carriers with a biological identity to better interact with the biological environment. Immune cells for example employ membrane proteins to target inflamed vasculature, locally increase vascular permeability, and extravasate across inflamed endothelium. Inspired by the physiology of immune cells, we recently developed a procedure to transfer leukocyte membranes onto nanoporous silicon particles (NPS), yielding Leukolike Vectors (LLV)...
October 5, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27628170/biomimetic-self-cleaning-surfaces-synthesis-mechanism-and-applications
#5
REVIEW
Quan Xu, Wenwen Zhang, Chenbo Dong, Theruvakkattil Sreenivasan Sreeprasad, Zhenhai Xia
With millions of years of natural evolution, organisms have achieved sophisticated structures, patterns or textures with complex, spontaneous multifunctionality. Among all the fascinating characteristics observed in biosystems, self-cleaning ability is regarded as one of the most interesting topics in biomimicry because of its potential applications in various fields such as aerospace, energy conversion and biomedical and environmental protection. Recently, in-depth studies have been carried out on various compelling biostructures including lotus leaves, shark skins, butterfly wings and gecko feet...
September 2016: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/27611963/designing-industrial-networks-using-ecological-food-web-metrics
#6
Astrid Layton, Bert Bras, Marc Weissburg
Biologically Inspired Design (biomimicry) and Industrial Ecology both look to natural systems to enhance the sustainability and performance of engineered products, systems and industries. Bioinspired design (BID) traditionally has focused on a unit operation and single product level. In contrast, this paper describes how principles of network organization derived from analysis of ecosystem properties can be applied to industrial system networks. Specifically, this paper examines the applicability of particular food web matrix properties as design rules for economically and biologically sustainable industrial networks, using an optimization model developed for a carpet recycling network...
October 18, 2016: Environmental Science & Technology
https://www.readbyqxmd.com/read/27558454/design-and-development-of-ph-responsive-hspc-c12h25-paa-chimeric-liposomes
#7
Nikolaos Naziris, Natassa Pippa, Anastasia Meristoudi, Stergios Pispas, Costas Demetzos
The application of stimuli-responsive medical practices has emerged, in which pH-sensitive liposomes figure prominently. This study investigates the impact of the incorporation of different amounts of pH-sensitive polymer, C12H25-PAA (poly(acrylic acid) with a hydrophobic end group) in L-α-phosphatidylcholine, hydrogenated (Soy) (HSPC) phospholipidic bilayers, with respect to biomimicry and functionality. PAA is a poly(carboxylic acid) molecule, classified as a pH-sensitive polymer, whose pH-sensitivity is attributed to its regulative -COOH groups, which are protonated under acidic pH (pKa∼4...
August 25, 2016: Journal of Liposome Research
https://www.readbyqxmd.com/read/27527120/in-vitro-cyclic-compressive-loads-potentiate-early-osteogenic-events-in-engineered-bone-tissue
#8
Akhilandeshwari Ravichandran, Jing Lim, Mark Seow Khoon Chong, Feng Wen, Yuchun Liu, Yaesshna T Pillay, Jerry K Y Chan, Swee-Hin Teoh
Application of dynamic mechanical loads on bone and bone explants has been reported to enhance osteogenesis and mineralization. To date, published studies have incorporated a range of cyclic strains on 3D scaffolds and platforms to demonstrate the effect of mechanical loading on osteogenesis. However, most of the loading parameters used in these studies do not emulate the in vivo loading conditions. In addition, the scaffolds/platforms are not representative of the native osteoinductive environment of bone tissue and hence may not be entirely accurate to study the in vivo mechanical loading...
August 16, 2016: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/27510041/recent-advances-in-the-biomimicry-of-structural-colours
#9
REVIEW
Ahu Gümrah Dumanli, Thierry Savin
Nature has mastered the construction of nanostructures with well-defined macroscopic effects and purposes. Structural colouration is a visible consequence of the particular patterning of a reflecting surface with regular structures at submicron length scales. Structural colours usually appear bright, shiny, iridescent or with a metallic look, as a result of physical processes such as diffraction, interference, or scattering with a typically small dissipative loss. These features have recently attracted much research effort in materials science, chemistry, engineering and physics, in order to understand and produce structural colours...
August 11, 2016: Chemical Society Reviews
https://www.readbyqxmd.com/read/27447414/exploring-the-design-of-a-lightweight-sustainable-and-comfortable-aircraft-seat
#10
A Kokorikou, P Vink, I C de Pauw, A Braca
BACKGROUND: Making a lightweight seat that is also comfortable can be contradictory because usually comfort improvement means adding a feature (e.g. headrest, adjustable lumbar support, movable armrests, integrated massage systems, etc.), which makes seats heavier. OBJECTIVE: This paper explores the design of an economy class aircraft seat that aims to be lightweight, comfortable and sustainable. METHODS: Theory about comfort in seats, ergonomics, lightweight design, Biomimicry and Cradle to cradle was studied and resulted in a list of requirements that the new seat should satisfy...
July 19, 2016: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/27431574/3d-bioprinting-of-bm-mscs-loaded-ecm-biomimetic-hydrogels-for-in-vitro-neocartilage-formation
#11
Marco Costantini, Joanna Idaszek, Krisztina Szöke, Jakub Jaroszewicz, Mariella Dentini, Andrea Barbetta, Jan E Brinchmann, Wojciech Święszkowski
In this work we demonstrate how to print 3D biomimetic hydrogel scaffolds for cartilage tissue engineering with high cell density (>10(7) cells ml(-1)), high cell viability (85 ÷ 90%) and high printing resolution (≈100 μm) through a two coaxial-needles system. The scaffolds were composed of modified biopolymers present in the extracellular matrix (ECM) of cartilage, namely gelatin methacrylamide (GelMA), chondroitin sulfate amino ethyl methacrylate (CS-AEMA) and hyaluronic acid methacrylate (HAMA). The polymers were used to prepare three photocurable bioinks with increasing degree of biomimicry: (i) GelMA, (ii) GelMA + CS-AEMA and (iii) GelMA + CS-AEMA + HAMA...
2016: Biofabrication
https://www.readbyqxmd.com/read/27381524/diversification-and-enrichment-of-clinical-biomaterials-inspired-by-darwinian-evolution
#12
REVIEW
D W Green, G S Watson, J A Watson, D-J Lee, J-M Lee, H-S Jung
UNLABELLED: Regenerative medicine and biomaterials design are driven by biomimicry. There is the essential requirement to emulate human cell, tissue, organ and physiological complexity to ensure long-lasting clinical success. Biomimicry projects for biomaterials innovation can be re-invigorated with evolutionary insights and perspectives, since Darwinian evolution is the original dynamic process for biological organisation and complexity. Many existing human inspired regenerative biomaterials (defined as a nature generated, nature derived and nature mimicking structure, produced within a biological system, which can deputise for, or replace human tissues for which it closely matches) are without important elements of biological complexity such as, hierarchy and autonomous actions...
September 15, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27356114/bioinspired-graphene-based-nanocomposites-and-their-application-in-flexible-energy-devices
#13
Sijie Wan, Jingsong Peng, Lei Jiang, Qunfeng Cheng
Graphene is the strongest and stiffest material ever identified and the best electrical conductor known to date, making it an ideal candidate for constructing nanocomposites used in flexible energy devices. However, it remains a great challenge to assemble graphene nanosheets into macro-sized high-performance nanocomposites in practical applications of flexible energy devices using traditional approaches. Nacre, the gold standard for biomimicry, provides an excellent example and guideline for assembling two-dimensional nanosheets into high-performance nanocomposites...
June 29, 2016: Advanced Materials
https://www.readbyqxmd.com/read/27313997/patterning-biomaterials-for-the-spatiotemporal-delivery-of-bioactive-molecules
#14
REVIEW
Silvia Minardi, Francesca Taraballi, Laura Pandolfi, Ennio Tasciotti
The aim of tissue engineering is to promote the repair of functional tissues. For decades, the combined use of biomaterials, growth factors (GFs), and stem cells has been the base of several regeneration strategies. Among these, biomimicry emerged as a robust strategy to efficiently address this clinical challenge. Biomimetic materials, able to recapitulate the composition and architecture of the extracellular matrix, are the materials of choice, for their biocompatibility and higher rate of efficacy. In addition, it has become increasingly clear that restoring the complex biochemical environment of the target tissue is crucial for its regeneration...
2016: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/27285812/forming-giant-sized-polymersomes-using-gel-assisted-rehydration
#15
Adrienne C Greene, Darryl Y Sasaki, George D Bachand
Polymer vesicles, or polymersomes, are being widely explored as synthetic analogs of lipid vesicles based on their stability, robustness, barrier properties, chemical versatility and tunable physical characteristics. Typical methods used to prepare giant-sized (> 4 µm) vesicles, however, are both time and labor intensive, yielding low numbers of intact polymersomes. Here, we present for the first time the use of gel-assisted rehydration for the rapid and high-yielding formation of giant (>4 µm) polymer vesicles (polymersomes)...
2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27258099/a-d-shaped-bileaflet-bioprosthesis-which-replicates-physiological-left-ventricular-flow-patterns
#16
Sean Guo-Dong Tan, Sangho Kim, Jimmy Kim Fatt Hon, Hwa Liang Leo
Prior studies have shown that in a healthy heart, there exist a large asymmetric vortex structure that aids in establishing a steady flow field in the left ventricle. However, the implantation of existing artificial heart valves at the mitral position is found to have a negative effect on this physiological flow pattern. In light of this, a novel D-shaped bileaflet porcine bioprosthesis (GD valve) has been designed based on the native geometry mitral valve, with the hypothesis that biomimicry in valve design can restore physiological left ventricle flow patterns after valve implantation...
2016: PloS One
https://www.readbyqxmd.com/read/27221469/biomimetic-rehabilitation-engineering-the-importance-of-somatosensory-feedback-for-brain-machine-interfaces
#17
David Perruchoud, Iolanda Pisotta, Stefano Carda, Micah M Murray, Silvio Ionta
OBJECTIVE: Brain-machine interfaces (BMIs) re-establish communication channels between the nervous system and an external device. The use of BMI technology has generated significant developments in rehabilitative medicine, promising new ways to restore lost sensory-motor functions. However and despite high-caliber basic research, only a few prototypes have successfully left the laboratory and are currently home-deployed. APPROACH: The failure of this laboratory-to-user transfer likely relates to the absence of BMI solutions for providing naturalistic feedback about the consequences of the BMI's actions...
August 2016: Journal of Neural Engineering
https://www.readbyqxmd.com/read/27176456/biomimicry-may-cure-obstructive-sleep-apnea
#18
Macario Camacho, Sungjin A Song, Anthony M Tolisano
No abstract text is available yet for this article.
May 2016: Cranio: the Journal of Craniomandibular Practice
https://www.readbyqxmd.com/read/27125190/poly-lactic-acid-nanofibrous-scaffolds-for-tissue-engineering
#19
REVIEW
Marco Santoro, Sarita R Shah, Jennifer L Walker, Antonios G Mikos
Poly(lactic acid) (PLA) is a synthetic polyester that has shown extensive utility in tissue engineering. Synthesized either by ring opening polymerization or polycondensation, PLA hydrolytically degrades into lactic acid, a metabolic byproduct, making it suitable for medical applications. Specifically, PLA nanofibers have widened the possible uses of PLA scaffolds for regenerative medicine and drug delivery applications. The use of nanofibrous scaffolds imparts a host of desirable properties, including high surface area, biomimicry of native extracellular matrix architecture, and tuning of mechanical properties, all of which are important facets of designing scaffolds for a particular organ system...
April 26, 2016: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/27039951/graphene-based-artificial-nacre-nanocomposites
#20
Yuanyuan Zhang, Shanshan Gong, Qi Zhang, Peng Ming, Sijie Wan, Jingsong Peng, Lei Jiang, Qunfeng Cheng
With its extraordinary properties as the strongest and stiffest material ever measured and the best-known electrical conductor, graphene could have promising applications in many fields, especially in the area of nanocomposites. However, processing graphene-based nanocomposites is very difficult. So far, graphene-based nanocomposites exhibit rather poor properties. Nacre, the gold standard for biomimicry, provides an excellent example and guidelines for assembling two-dimensional nanosheets into high performance nanocomposites...
May 3, 2016: Chemical Society Reviews
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