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Biomimicry

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https://www.readbyqxmd.com/read/28881469/biomimicry-biofabrication-and-biohybrid-systems-the-emergence-and-evolution-of-biological-design
#1
REVIEW
Ritu Raman, Rashid Bashir
The discipline of biological design has a relatively short history, but has undergone very rapid expansion and development over that time. This Progress Report outlines the evolution of this field from biomimicry to biofabrication to biohybrid systems' design, showcasing how each subfield incorporates bioinspired dynamic adaptation into engineered systems. Ethical implications of biological design are discussed, with an emphasis on establishing responsible practices for engineering non-natural or hypernatural functional behaviors in biohybrid systems...
September 7, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28852039/laser-assisted-rapid-mineralization-of-human-tooth-enamel
#2
Muyang Sun, Nier Wu, Haifeng Chen
The human body has difficulty repairing damaged dental enamel, an acellular hard tissue. Researchers have sought feasible biomimicry strategies to repair enamel defects; however, few have been successfully translated to clinical applications. In this study, we propose a new method for achieving rapid enamel mineralization under a near-physiological environment. Through treatment with a laser and chelating agents, 15 μm crystals could be grown compactly on an enamel substrate in less than 20 min. The compact crystal layer had similar structure as native enamel prisms and high elastic modulus...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28822737/printing-nature-unraveling-the-role-of-nacre-s-mineral-bridges
#3
Grace X Gu, Flavia Libonati, Susan D Wettermark, Markus J Buehler
Creating materials with strength and toughness has been a long-sought goal. Conventional engineering materials often face a trade-off between strength and toughness, prompting researchers seeking to overcome these limitations to explore more sophisticated materials, such as composites. This paradigm shift in material design is spurred by nature, which exhibits a plethora of heterogeneous materials that offer outstanding material properties, and many natural materials are widely regarded as examples of high-performing hybrid materials...
May 4, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28806646/static-flexural-properties-of-hedgehog-spines-conditioned-in-coupled-temperature-and-relative-humidity-environments
#4
Emily B Kennedy, Bor-Kai Hsiung, Nathan B Swift, Kwek-Tze Tan
Hedgehogs are agile climbers, scaling trees and plants to heights exceeding 10m while foraging insects. Hedgehog spines (a.k.a. quills) provide fall protection by absorbing shock and could offer insights for the design of lightweight, material-efficient, impact-resistant structures. There has been some study of flexural properties of hedgehog spines, but an understanding of how this keratinous biological material is affected by various temperature and relative humidity treatments, or how spine color (multicolored vs...
August 5, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28791761/biomimicry-of-artificial-spider-silk-spinning-assessed-by-nmr
#5
Martins Otikovs, Marlene Andersson, Qiupin Jia, Kerstin Nordling, Qing Meng, Loren B Andreas, Guido Pintacuda, Jan Johansson, Anna Rising, Kristaps Jaudzems
Biomimetic spinning of artificial spider silk requires that the terminal domains of designed minispidroins undergo specific structural changes in concert with the β-sheet conversion of the repetitive region. Here, we combine solution and solid state NMR methods to probe domain-specific structural changes in the NT2RepCT minispidroin, which allows us to assess the degree of biomimicry of artificial silk spinning. In addition, we show that the structural effects of post-spinning procedures can be examined. By studying the impact of NT2RepCT fiber drying we observed a reversible beta-to-alpha conversion...
August 9, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28782725/the-bio-in-the-ink-cartilage-regeneration-with-bioprintable-hydrogels-and-articular-cartilage-derived-progenitor-cells
#6
Riccardo Levato, William R Webb, Iris A Otto, Anneloes Mensinga, Yadan Zhang, Mattie van Rijen, René van Weeren, Ilyas M Khan, Jos Malda
Cell-laden hydrogels are the primary building blocks for bioprinting, and, also termed bioinks, are the foundations for creating structures that can potentially recapitulate the architecture of articular cartilage. To be functional, hydrogel constructs need to unlock the regenerative capacity of encapsulated cells. The recent identification of multipotent articular cartilage-resident chondroprogenitor cells (ACPCs), which share important traits with adult stem cells, represents a new opportunity for cartilage regeneration...
August 4, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28762415/biocompatible-3d-printed-polymers-via-fused-deposition-modelling-direct-c2c12-cellular-phenotype-in-vitro
#7
Rowan P Rimington, Andrew J Capel, Steven D R Christie, Mark P Lewis
The capability to 3D print bespoke biologically receptive parts within short time periods has driven the growing prevalence of additive manufacture (AM) technology within biological settings, however limited research concerning cellular interaction with 3D printed polymers has been undertaken. In this work, we used skeletal muscle C2C12 cell line in order to ascertain critical evidence of cellular behaviour in response to multiple bio-receptive candidate polymers; polylactic acid (PLA), acrylonitrile butadiene styrene (ABS), polyethylene terephthalate (PET) and polycarbonate (PC) 3D printed via fused deposition modelling (FDM)...
August 1, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28751113/tissue-engineering-in-hand-surgery-a%C3%A2-technology-update
#8
REVIEW
Hayman Lui, Cedryck Vaquette, Randip Bindra
The field of hand surgery is constantly evolving to meet the challenges of repairing intricate anatomical structures with limited availability of donor tissue. The past 10 years have seen an exponential growth in tissue engineering, which has broadened the perspectives of tackling these age-old problems. Various fabrication techniques such as melt electrospinning and fused deposition modelling have been employed to synthesize 3-dimensional bioscaffolds that can be used to replace lost tissue. These bioscaffolds with strategic biomimicry have been shown to allow for integrative and functional repair of tissue injuries...
September 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28745057/nanoscale-ion-pump-derived-from-a-biological-water-channel
#9
Karl Decker, Martin Page, Aleksei Aksimentiev
Biological molecular machines perform the work of supporting life at the smallest of scales, including the work of shuttling ions across cell boundaries and against chemical gradients. Systems of artificial channels at the nanoscale can likewise control ionic concentration by way of ionic current rectification, species selectivity, and voltage gating mechanisms. Here, we theoretically show that a voltage-gated, ion species-selective, and rectifying ion channel can be built using the components of a biological water channel aquaporin...
August 24, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28685239/a-biodesign-approach-to-obtain-high-yields-of-biosimilars-by-anti-apoptotic-cell-engineering-a-case-study-to-increase-the-production-yield-of-anti-tnf-alpha-producing-recombinant-cho-cells
#10
Sultan Gulce Iz, Muge Anil Inevi, Pelin Saglam Metiner, Duygu Ayyildiz Tamis, Nazli Kisbet
Recent developments in medical biotechnology have facilitated to enhance the production of monoclonal antibodies (mAbs) and recombinant proteins in mammalian cells. Human mAbs for clinical applications have focused on three areas, particularly cancer, immunological disorders, and infectious diseases. Tumor necrosis factor alpha (TNF-α), which has both proinflammatory and immunoregulatory functions, is an important target in biopharmaceutical industry. In this study, a humanized anti-TNF-α mAb producing stable CHO cell line which produces a biosimilar of Humira (adalimumab) was used...
July 6, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28675029/binary-doping-of-strontium-and-copper-enhancing-osteogenesis-and-angiogenesis-of-bioactive-glass-nanofibers-while-suppressing-osteoclast-activity
#11
Lin Weng, Sunil Kumar Boda, Matthew J Teusink, Franklin D Shuler, Xiaoran Li, Jingwei Xie
Electrospun bioactive glass fibers show great potential as scaffolds for bone tissue engineering due to their architectural biomimicry of the bone extracellular matrix and their composition capable of providing soluble bioactive cues for bone regeneration and remodeling. Trace elements can be doped to further promote osteogenesis and angiogenesis during bone regeneration. Cationic substitution of strontium for calcium in bioactive glass positively enhances osteoblast phenotype, while suppressing osteoclast activity...
July 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28670465/microfluidic-on-chip-biomimicry-for-3d-cell-culture-a-fit-for-purpose-investigation-from-the-end-user-standpoint
#12
REVIEW
Ye Liu, Elisabeth Gill, Yan Yan Shery Huang
A plethora of 3D and microfluidics-based culture models have been demonstrated in the recent years with the ultimate aim to facilitate predictive in vitro models for pharmaceutical development. This article summarizes to date the progress in the microfluidics-based tissue culture models, including organ-on-a-chip and vasculature-on-a-chip. Specific focus is placed on addressing the question of what kinds of 3D culture and system complexities are deemed desirable by the biological and biomedical community. This question is addressed through analysis of a research survey to evaluate the potential use of microfluidic cell culture models among the end users...
June 2017: Future Science OA
https://www.readbyqxmd.com/read/28653043/bioactive-polymeric-scaffolds-for-tissue-engineering
#13
Scott Stratton, Namdev B Shelke, Kazunori Hoshino, Swetha Rudraiah, Sangamesh G Kumbar
A variety of engineered scaffolds have been created for tissue engineering using polymers, ceramics and their composites. Biomimicry has been adopted for majority of the three-dimensional (3D) scaffold design both in terms of physicochemical properties, as well as bioactivity for superior tissue regeneration. Scaffolds fabricated via salt leaching, particle sintering, hydrogels and lithography have been successful in promoting cell growth in vitro and tissue regeneration in vivo. Scaffold systems derived from decellularization of whole organs or tissues has been popular due to their assured biocompatibility and bioactivity...
December 2016: Bioactive Materials
https://www.readbyqxmd.com/read/28562185/hypoxia-biomimicry-to-enhance-monetite-bone-defect-repair
#14
Justin Drager, Jose Luis Ramirez-GarciaLuna, Abhishek Kumar, Uwe Gbureck, Edward J Harvey, Jake E Barralet
Tissue hypoxia is a critical driving force for angiogenic and osteogenic responses in bone regeneration and is, at least partly, under the control of the Hypoxia Inducible Factor-1α (HIF-1α) pathway. Recently, the widely used iron chelator deferoxamine (DFO) has been found to elevate HIF-1α levels independent of oxygen concentrations, thereby, creating an otherwise normal environment that mimics the hypoxic state. This has the potential to augment the biological properties of inorganic scaffolds without the need of recombinant growth factors...
July 19, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28503119/targeting-hiv-1-envelope-proteins-using-a-fragment-discovery-all-atom-computational-algorithm
#15
Michael H Peters
INTRODUCTION: HIV viral envelope proteins are targets for small inhibitor molecules aimed at disrupting the cellular entry process. Potential peptide-class inhibitor molecules (rDNA drugs) have been previously identified, with mixed results, through biomimicry and phage display experimental methods. Here we describe a new approach based on computational fragment discovery. The method has the potential to not only optimize peptide binding affinity but also to rapidly produce alternative inhibitors against mutated strains...
April 2017: Current Enzyme Inhibition
https://www.readbyqxmd.com/read/28500310/bio-inspired-nacre-like-nanolignocellulose-poly-vinyl-alcohol-tio2-composite-with-superior-mechanical-and-photocatalytic-properties
#16
Yipeng Chen, Hanwei Wang, Baokang Dang, Ye Xiong, Qiufang Yao, Chao Wang, Qingfeng Sun, Chunde Jin
Nacre, the gold standard for biomimicry, provides an excellent example and guideline for assembling high-performance composites. Inspired by the layered structure and extraordinary strength and toughness of natural nacre, nacre-like nanolignocellulose/poly (vinyl alcohol)/TiO2 composites possessed the similar layered structure of natural nacre were constructed through hot-pressing process. Poly (vinyl alcohol) and TiO2 nanoparticles have been used as nanofillers to improve the mechanical performance and synchronously endow the superior photocatalytic activity of the composites...
May 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28470049/second-order-biomimicry-in-situ-oxidative-self-processing-converts-copper-i-diamine-precursor-into-a-highly-active-aerobic-oxidation-catalyst
#17
Scott D McCann, Jean-Philip Lumb, Bruce A Arndtsen, Shannon S Stahl
A homogeneous Cu-based catalyst system consisting of [Cu(MeCN)4]PF6, N,N'-di-tert-butylethylenediamine (DBED), and p-(N,N-dimethylamino)pyridine (DMAP) mediates efficient aerobic oxidation of alcohols. Mechanistic study of this reaction shows that the catalyst undergoes an in situ oxidative self-processing step, resulting in conversion of DBED into a nitroxyl that serves as an efficient cocatalyst for aerobic alcohol oxidation. Insights into this behavior are gained from kinetic studies, which reveal an induction period at the beginning of the reaction that correlates with the oxidative self-processing step, EPR spectroscopic analysis of the catalytic reaction mixture, which shows the buildup of the organic nitroxyl species during steady state turnover, and independent synthesis of oxygenated DBED derivatives, which are shown to serve as effective cocatalysts and eliminate the induction period in the reaction...
April 26, 2017: ACS Central Science
https://www.readbyqxmd.com/read/28450393/immunoglobulin-domain-interface-exchange-as-a-platform-technology-for-the-generation-of-fc-heterodimers-and-bispecific-antibodies
#18
Darko Skegro, Cian Stutz, Romain Ollier, Emelie Svensson, Paul Wassmann, Florence Bourquin, Thierry Monney, Sunitha Gn, Stanislas Blein
Bispecific antibodies (bsAbs) are of significant importance to the development of novel antibody-based therapies, and heavy chain (Hc) heterodimers represent a major class of bispecific drug candidates. Current technologies for the generation of Hc heterodimers are suboptimal and often suffer from contamination by homodimers posing purification challenges. Here, we introduce a new technology based on biomimicry wherein the protein-protein interfaces of two different immunoglobulin (Ig) constant domain pairs are exchanged in part or fully to design new heterodimeric domains...
June 9, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28447768/bio-inspired-bright-structurally-colored-colloidal-amorphous-array-enhanced-by-controlling-thickness-and-black-background
#19
Masanori Iwata, Midori Teshima, Takahiro Seki, Shinya Yoshioka, Yukikazu Takeoka
Inspired by Steller's jay, which displays angle-independent structural colors, angle-independent structurally colored materials are created, which are composed of amorphous arrays of submicrometer-sized fine spherical silica colloidal particles. When the colloidal amorphous arrays are thick, they do not appear colorful but almost white. However, the saturation of the structural color can be increased by (i) appropriately controlling the thickness of the array and (ii) placing the black background substrate...
April 26, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28386187/biomimicry-of-symbiotic-multi-species-coevolution-for-discrete-and-continuous-optimization-in-rfid-networks
#20
Na Lin, Hanning Chen, Shikai Jing, Fang Liu, Xiaodan Liang
In recent years, symbiosis as a rich source of potential engineering applications and computational model has attracted more and more attentions in the adaptive complex systems and evolution computing domains. Inspired by different symbiotic coevolution forms in nature, this paper proposed a series of multi-swarm particle swarm optimizers called PS(2)Os, which extend the single population particle swarm optimization (PSO) algorithm to interacting multi-swarms model by constructing hierarchical interaction topologies and enhanced dynamical update equations...
March 2017: Saudi Journal of Biological Sciences
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