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Biomimicry

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https://www.readbyqxmd.com/read/28685239/a-biodesign-approach-to-obtain-high-yields-of-biosimilars-by-anti-apoptotic-cell-engineering-a-case-study-to-increase-the-production-yield-of-anti-tnf-alpha-producing-recombinant-cho-cells
#1
Sultan Gulce Iz, Muge Anil Inevi, Pelin Saglam Metiner, Duygu Ayyildiz Tamis, Nazli Kisbet
Recent developments in medical biotechnology have facilitated to enhance the production of monoclonal antibodies (mAbs) and recombinant proteins in mammalian cells. Human mAbs for clinical applications have focused on three areas, particularly cancer, immunological disorders, and infectious diseases. Tumor necrosis factor alpha (TNF-α), which has both proinflammatory and immunoregulatory functions, is an important target in biopharmaceutical industry. In this study, a humanized anti-TNF-α mAb producing stable CHO cell line which produces a biosimilar of Humira (adalimumab) was used...
July 6, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28675029/binary-doping-of-strontium-and-copper-enhancing-osteogenesis-and-angiogenesis-of-bioactive-glass-nanofibers-while-suppressing-osteoclast-activity
#2
Lin Weng, Sunil Kumar Boda, Matthew Teusink, Franklin D Shuler, Xiaoran Li, Jingwei Xie
Electrospun bioactive glass fibers show great potential as scaffolds for bone tissue engineering due to their architectural biomimicry of the bone extracellular matrix and their composition capable of providing soluble bioactive cues for bone regeneration and remodeling. Trace elements can be doped to further promote osteogenesis and angiogenesis during bone regeneration. Cationic substitution of strontium for calcium in bioactive glass positively enhances osteoblast phenotype, while suppressing osteoclast activity...
July 4, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28670465/microfluidic-on-chip-biomimicry-for-3d-cell-culture-a-fit-for-purpose-investigation-from-the-end-user-standpoint
#3
REVIEW
Ye Liu, Elisabeth Gill, Yan Yan Shery Huang
A plethora of 3D and microfluidics-based culture models have been demonstrated in the recent years with the ultimate aim to facilitate predictive in vitro models for pharmaceutical development. This article summarizes to date the progress in the microfluidics-based tissue culture models, including organ-on-a-chip and vasculature-on-a-chip. Specific focus is placed on addressing the question of what kinds of 3D culture and system complexities are deemed desirable by the biological and biomedical community. This question is addressed through analysis of a research survey to evaluate the potential use of microfluidic cell culture models among the end users...
June 2017: Future Science OA
https://www.readbyqxmd.com/read/28653043/bioactive-polymeric-scaffolds-for-tissue-engineering
#4
Scott Stratton, Namdev B Shelke, Kazunori Hoshino, Swetha Rudraiah, Sangamesh G Kumbar
A variety of engineered scaffolds have been created for tissue engineering using polymers, ceramics and their composites. Biomimicry has been adopted for majority of the three-dimensional (3D) scaffold design both in terms of physicochemical properties, as well as bioactivity for superior tissue regeneration. Scaffolds fabricated via salt leaching, particle sintering, hydrogels and lithography have been successful in promoting cell growth in vitro and tissue regeneration in vivo. Scaffold systems derived from decellularization of whole organs or tissues has been popular due to their assured biocompatibility and bioactivity...
December 2016: Bioactive Materials
https://www.readbyqxmd.com/read/28562185/hypoxia-biomimicry-to-enhance-monetite-bone-defect-repair
#5
Justin Drager, Jose Luis Ramirez-GarciaLuna, Abhishek Kumar, Uwe Gbureck, Edward J Harvey, Jake Barralet
Tissue hypoxia is a critical driving force for angiogenic and osteogenic responses in bone regeneration and is, at least partly, under the control of the Hypoxia Inducible Factor-1α (HIF-1α) pathway. Recently, the widely used iron chelator Deferoxamine (DFO) has been found to elevate HIF-1α levels independent of oxygen concentrations, thereby, creating an otherwise normal environment that mimics the hypoxic state. This has the potential to augment the biological properties of inorganic scaffolds without the need of recombinant growth factors...
May 31, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28503119/targeting-hiv-1-envelope-proteins-using-a-fragment-discovery-all-atom-computational-algorithm
#6
Michael H Peters
INTRODUCTION: HIV viral envelope proteins are targets for small inhibitor molecules aimed at disrupting the cellular entry process. Potential peptide-class inhibitor molecules (rDNA drugs) have been previously identified, with mixed results, through biomimicry and phage display experimental methods. Here we describe a new approach based on computational fragment discovery. The method has the potential to not only optimize peptide binding affinity but also to rapidly produce alternative inhibitors against mutated strains...
April 2017: Current Enzyme Inhibition
https://www.readbyqxmd.com/read/28500310/bio-inspired-nacre-like-nanolignocellulose-poly-vinyl-alcohol-tio2-composite-with-superior-mechanical-and-photocatalytic-properties
#7
Yipeng Chen, Hanwei Wang, Baokang Dang, Ye Xiong, Qiufang Yao, Chao Wang, Qingfeng Sun, Chunde Jin
Nacre, the gold standard for biomimicry, provides an excellent example and guideline for assembling high-performance composites. Inspired by the layered structure and extraordinary strength and toughness of natural nacre, nacre-like nanolignocellulose/poly (vinyl alcohol)/TiO2 composites possessed the similar layered structure of natural nacre were constructed through hot-pressing process. Poly (vinyl alcohol) and TiO2 nanoparticles have been used as nanofillers to improve the mechanical performance and synchronously endow the superior photocatalytic activity of the composites...
May 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28470049/second-order-biomimicry-in-situ-oxidative-self-processing-converts-copper-i-diamine-precursor-into-a-highly-active-aerobic-oxidation-catalyst
#8
Scott D McCann, Jean-Philip Lumb, Bruce A Arndtsen, Shannon S Stahl
A homogeneous Cu-based catalyst system consisting of [Cu(MeCN)4]PF6, N,N'-di-tert-butylethylenediamine (DBED), and p-(N,N-dimethylamino)pyridine (DMAP) mediates efficient aerobic oxidation of alcohols. Mechanistic study of this reaction shows that the catalyst undergoes an in situ oxidative self-processing step, resulting in conversion of DBED into a nitroxyl that serves as an efficient cocatalyst for aerobic alcohol oxidation. Insights into this behavior are gained from kinetic studies, which reveal an induction period at the beginning of the reaction that correlates with the oxidative self-processing step, EPR spectroscopic analysis of the catalytic reaction mixture, which shows the buildup of the organic nitroxyl species during steady state turnover, and independent synthesis of oxygenated DBED derivatives, which are shown to serve as effective cocatalysts and eliminate the induction period in the reaction...
April 26, 2017: ACS Central Science
https://www.readbyqxmd.com/read/28450393/immunoglobulin-domain-interface-exchange-as-a-platform-technology-for-the-generation-of-fc-heterodimers-and-bispecific-antibodies
#9
Darko Skegro, Cian Stutz, Romain Ollier, Emelie Svensson, Paul Wassmann, Florence Bourquin, Thierry Monney, Sunitha Gn, Stanislas Blein
Bispecific antibodies (bsAbs) are of significant importance to the development of novel antibody-based therapies, and heavy chain (Hc) heterodimers represent a major class of bispecific drug candidates. Current technologies for the generation of Hc heterodimers are suboptimal and often suffer from contamination by homodimers posing purification challenges. Here, we introduce a new technology based on biomimicry wherein the protein-protein interfaces of two different immunoglobulin (Ig) constant domain pairs are exchanged in part or fully to design new heterodimeric domains...
June 9, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28447768/bio-inspired-bright-structurally-colored-colloidal-amorphous-array-enhanced-by-controlling-thickness-and-black-background
#10
Masanori Iwata, Midori Teshima, Takahiro Seki, Shinya Yoshioka, Yukikazu Takeoka
Inspired by Steller's jay, which displays angle-independent structural colors, angle-independent structurally colored materials are created, which are composed of amorphous arrays of submicrometer-sized fine spherical silica colloidal particles. When the colloidal amorphous arrays are thick, they do not appear colorful but almost white. However, the saturation of the structural color can be increased by (i) appropriately controlling the thickness of the array and (ii) placing the black background substrate...
April 26, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28386187/biomimicry-of-symbiotic-multi-species-coevolution-for-discrete-and-continuous-optimization-in-rfid-networks
#11
Na Lin, Hanning Chen, Shikai Jing, Fang Liu, Xiaodan Liang
In recent years, symbiosis as a rich source of potential engineering applications and computational model has attracted more and more attentions in the adaptive complex systems and evolution computing domains. Inspired by different symbiotic coevolution forms in nature, this paper proposed a series of multi-swarm particle swarm optimizers called PS(2)Os, which extend the single population particle swarm optimization (PSO) algorithm to interacting multi-swarms model by constructing hierarchical interaction topologies and enhanced dynamical update equations...
March 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/28358401/nanomaterial-based-bone-regeneration
#12
REVIEW
Yulin Li, Changsheng Liu
Bone diseases/injuries have been driving an urgent quest for bone substitutes for bone regeneration. Nanoscaled materials with bone-mimicking characteristics may create suitable microenvironments to guide effective bone regeneration. In this review, the natural hierarchical architecture of bone and its regeneration mechanisms are elucidated. Recent progress in the development of nanomaterials which can promote bone regeneration through bone-healing mimicry (e.g., compositional, nanocrystal formation, structural, and growth factor-related mimicking) is summarized...
March 30, 2017: Nanoscale
https://www.readbyqxmd.com/read/28350434/stepwise-synthesis-of-metal-organic-frameworks
#13
Mathieu Bosch, Shuai Yuan, William Rutledge, Hong-Cai Zhou
Metal-organic frameworks (MOFs) are a category of porous materials that offer unparalleled control over their surface areas (demonstrated as higher than for any other material), pore characteristics, and functionalization. This allows them to be customized for exceptional performance in a wide variety of applications, most commonly including gas storage and separation, drug delivery, luminescence, or heterogeneous catalysis. In order to optimize biomimicry, controlled separations and storage of small molecules, and detailed testing of structure-property relationships, one major goal of MOF research is "rational design" or "pore engineering", or precise control of the placement of multiple functional groups in pores of chosen sizes and shapes...
March 28, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28319779/supramolecular-biofunctional-materials
#14
REVIEW
Jie Zhou, Jie Li, Xuewen Du, Bing Xu
This review discusses supramolecular biofunctional materials, a novel class of biomaterials formed by small molecules that are held together via noncovalent interactions. The complexity of biology and relevant biomedical problems not only inspire, but also demand effective molecular design for functional materials. Supramolecular biofunctional materials offer (almost) unlimited possibilities and opportunities to address challenging biomedical problems. Rational molecular design of supramolecular biofunctional materials exploit powerful and versatile noncovalent interactions, which offer many advantages, such as responsiveness, reversibility, tunability, biomimicry, modularity, predictability, and, most importantly, adaptiveness...
June 2017: Biomaterials
https://www.readbyqxmd.com/read/28315813/the-case-for-applying-tissue-engineering-methodologies-to-instruct-human-organoid-morphogenesis
#15
REVIEW
Carlos R Marti-Figueroa, Randolph S Ashton
Three-dimensional organoids derived from human pluripotent stem cell (hPSC) derivatives have become widely used in vitro models for studying development and disease. Their ability to recapitulate facets of normal human development during in vitro morphogenesis produces tissue structures with unprecedented biomimicry. Current organoid derivation protocols primarily rely on spontaneous morphogenesis processes to occur within 3-D spherical cell aggregates with minimal to no exogenous control. This yields organoids containing microscale regions of biomimetic tissues, but at the macroscale (i...
March 16, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28264157/unveiling-the-in-vivo-protein-corona-of-circulating-leukocyte-like-carriers
#16
Claudia Corbo, Roberto Molinaro, Francesca Taraballi, Naama E Toledano Furman, Kelly A Hartman, Michael B Sherman, Enrica De Rosa, Dickson K Kirui, Francesco Salvatore, Ennio Tasciotti
Understanding interactions occurring at the interface between nanoparticles and biological components is an urgent challenge in nanomedicine due to their effect on the biological fate of nanoparticles. After the systemic injection of nanoparticles, a protein corona constructed by blood components surrounds the carrier's surface and modulates its pharmacokinetics and biodistribution. Biomimicry-based approaches in nanotechnology attempt to imitate what happens in nature in order to transfer specific natural functionalities to synthetic nanoparticles...
March 28, 2017: ACS Nano
https://www.readbyqxmd.com/read/28193622/from-imitation-to-inspiration-biomimicry-experiences-a-revival-driven-by-a-more-systematic-approach-to-explore-nature-s-inventions-for-human-use
#17
https://www.readbyqxmd.com/read/28191587/cytotoxic-responses-of-carnosic-acid-and-doxorubicin-on-breast-cancer-cells-in-butterfly-shaped-microchips-in-comparison-to-2d-and-3d-culture
#18
Ece Yildiz-Ozturk, Sultan Gulce-Iz, Muge Anil, Ozlem Yesil-Celiktas
Two dimensional (2D) cell culture systems lack the ability to mimic in vivo conditions resulting in limitations for preclinical cell-based drug and toxicity screening assays and modelling tumor biology. Alternatively, 3D cell culture systems mimic the specificity of native tissue with better physiological integrity. In this regard, microfluidic chips have gained wide applicability for in vitro 3D cancer cell studies. The aim of this research was to develop a 3D biomimetic model comprising culture of breast cancer cells in butterfly-shaped microchip to determine the cytotoxicity of carnosic acid and doxorubicin on both estrogen dependent (MCF-7) and independent (MDA-MB231) breast cancer cells along with healthy mammary epithelial cells (MCF-10A) in 2D, 3D Matrigel™ and butterfly-shaped microchip environment...
April 2017: Cytotechnology
https://www.readbyqxmd.com/read/28176941/bioglass-implant-coating-interactions-in-synthetic-physiological-fluids-with-varying-degrees-of-biomimicry
#19
A C Popa, G E Stan, M A Husanu, I Mercioniu, L F Santos, H R Fernandes, Jmf Ferreira
Synthetic physiological fluids are currently used as a first in vitro bioactivity assessment for bone grafts. Our understanding about the interactions taking place at the fluid-implant interface has evolved remarkably during the last decade, and does not comply with the traditional International Organization for Standardization/final draft International Standard 23317 protocol in purely inorganic simulated body fluid. The advances in our knowledge point to the need of a true paradigm shift toward testing physiological fluids with enhanced biomimicry and a better understanding of the materials' structure-dissolution behavior...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28075551/cucurbit-n-uril-based-microcapsules-self-assembled-within-microfluidic-droplets-a-versatile-approach-for-supramolecular-architectures-and-materials
#20
Ji Liu, Yang Lan, Ziyi Yu, Cindy S Y Tan, Richard M Parker, Chris Abell, Oren A Scherman
Microencapsulation is a fundamental concept behind a wide range of daily applications ranging from paints, adhesives, and pesticides to targeted drug delivery, transport of vaccines, and self-healing concretes. The beauty of microfluidics to generate microcapsules arises from the capability of fabricating monodisperse and micrometer-scale droplets, which can lead to microcapsules/particles with fine-tuned control over size, shape, and hierarchical structure, as well as high reproducibility, efficient material usage, and high-throughput manipulation...
February 21, 2017: Accounts of Chemical Research
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