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Cognitive function decision making

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https://www.readbyqxmd.com/read/28203201/modulation-of-synaptic-plasticity-in-the-cortex-needs-to-understand-all-the-players
#1
REVIEW
Claire N J Meunier, Pascal Chameau, Philippe M Fossier
The prefrontal cortex (PFC) is involved in cognitive tasks such as working memory, decision making, risk assessment and regulation of attention. These functions performed by the PFC are supposed to rely on rhythmic electrical activity generated by neuronal network oscillations determined by a precise balance between excitation and inhibition balance (E/I balance) resulting from the coordinated activities of recurrent excitation and feedback and feedforward inhibition. Functional alterations in PFC functions have been associated with cognitive deficits in several pathologies such as major depression, anxiety and schizophrenia...
2017: Frontiers in Synaptic Neuroscience
https://www.readbyqxmd.com/read/28203143/pregenual-anterior-cingulate-gyrus-involvement-in-spontaneous-social-interactions-in-primates-evidence-from-behavioral-pharmacological-neuropsychiatric-and-neurophysiological-findings
#2
Can Van Mao, Mariana F P Araujo, Hiroshi Nishimaru, Jumpei Matsumoto, Ahn Hai Tran, Etsuro Hori, Taketoshi Ono, Hisao Nishijo
The anterior cingulate cortex (ACC) has been implicated in different aspects of cognition and decision making, including social cognition. Several studies suggest that this region is actually formed by sub-regions concerned with distinct cognitive functions. The ACC is usually divided in its rostro-caudal axis, with the caudal ACC playing a major role in processing own actions, and the rostral ACC being related to social cognition. Recently, it has been suggested that the ACC can also be functionally divided in its dorso-ventral axis into ACC gyrus (ACCg) and ACC sulcus (ACCs), with the ACCg having a central role in processing social information...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28196313/executive-functioning-at-baseline-prospectively-predicts-depression-treatment-response
#3
Erica L Dawson, Angela F Caveney, Kortni K Meyers, Sara L Weisenbach, Bruno Giordani, Erich T Avery, Michael-Paul Schallmo, Armita Bahadori, Linas A Bieliauskas, Matthew Mordhorst, Sheila M Marcus, Kevin Kerber, Jon-Kar Zubieta, Scott A Langenecker
Objective: Existing cognitive and clinical predictors of treatment response to date are not of sufficient strength to meaningfully impact treatment decision making and are not readily employed in clinical settings. This study investigated whether clinical and cognitive markers used in a tertiary care clinic could predict response to usual treatment over a period of 4 to 6 months in a sample of 75 depressed adults. Methods: Patients (N = 384) were sequentially tested in 2 half-day clinics as part of a quality improvement project at an outpatient tertiary care center between August 2003 and September 2007; additional subjects evaluated in the clinic between 2007 and 2009 were also included...
February 9, 2017: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/28194721/determining-informative-priors-for-cognitive-models
#4
Michael D Lee, Wolf Vanpaemel
The development of cognitive models involves the creative scientific formalization of assumptions, based on theory, observation, and other relevant information. In the Bayesian approach to implementing, testing, and using cognitive models, assumptions can influence both the likelihood function of the model, usually corresponding to assumptions about psychological processes, and the prior distribution over model parameters, usually corresponding to assumptions about the psychological variables that influence those processes...
February 13, 2017: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/28193245/early-disease-progression-of-hurler-syndrome
#5
Bridget T Kiely, Jennifer L Kohler, Hannah Y Coletti, Michele D Poe, Maria L Escolar
BACKGROUND: Newborn screening for mucopolysaccharidosis type I (MPS I) shows promise to improve outcomes by facilitating early diagnosis and treatment. However, diagnostic tests for MPS I are of limited value in predicting whether a child will develop severe central nervous system disease associated with Hurler syndrome, or minimal or no central nervous system involvement associated with the attenuated phenotypes (Hurler-Scheie and Scheie syndromes). Given that the optimal treatment differs between Hurler syndrome and the attenuated MPS I phenotypes, the absence of a reliable prognostic biomarker complicates clinical decision making for infants diagnosed through newborn screening...
February 14, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28183030/estradiol-and-raloxifene-modulate-hippocampal-gamma-oscillations-during-a-spatial-memory-task
#6
Anna Schroeder, Matthew Hudson, Xin Du, Yee Wen Candace Wu, Jay Nakamura, Maarten van den Buuse, Nigel C Jones, Rachel A Hill
Previous work suggests that estradiol regulates the expression of hippocampal parvalbumin as well as hippocampus-dependent spatial memory in mice. Parvalbumin interneurons generate neuronal oscillatory activity in the gamma frequency range (30-80Hz) and gamma oscillations are closely linked with higher cognitive functions. Raloxifene, a selective estrogen receptor modulator, shows beneficial effects on human cognitive performance, and has few peripheral side effects unlike estradiol, but the biological mechanisms which underpin these benefits are not clear...
January 23, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28182166/reducing-the-risk-of-stroke-in-elderly-patients-with-non-valvular-atrial-fibrillation-a-practical-guide-for-clinicians
#7
REVIEW
Joanne M Foody
Non-valvular atrial fibrillation (NVAF) significantly contributes to the burden of stroke, particularly in elderly patients. The challenge of optimizing anticoagulation therapy is balancing efficacy and bleeding risk, especially as the same patients at high risk of stroke also tend to be at high risk of bleeding. Treating the elderly patient with NVAF presents special challenges because of their heightened risk for both stroke and bleeding. Despite clinical trial data and evidence-based guidelines, surveys indicate that physicians underuse anticoagulation in older patients for reasons that include overemphasis of bleeding risk, particularly with the increased risk of falling, at the cost of thromboembolic risk...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28162899/exceptional-evolutionary-expansion-of-prefrontal-cortex-in-great-apes-and-humans
#8
Jeroen B Smaers, Aida Gómez-Robles, Ashley N Parks, Chet C Sherwood
One of the enduring questions that has driven neuroscientific enquiry in the last century has been the nature of differences in the prefrontal cortex of humans versus other animals [1]. The prefrontal cortex has drawn particular interest due to its role in a range of evolutionarily specialized cognitive capacities such as language [2], imagination [3], and complex decision making [4]. Both cytoarchitectonic [5] and comparative neuroimaging [6] studies have converged on the conclusion that the proportion of prefrontal cortex in the human brain is greatly increased relative to that of other primates...
January 27, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28162778/neural-mechanisms-of-mood-induced-modulation-of-reality-monitoring-in-schizophrenia
#9
Karuna Subramaniam, Kamalini G Ranasinghe, Daniel Mathalon, Srikantan Nagarajan, Sophia Vinogradov
Reality monitoring is the ability to accurately distinguish the source of self-generated information from externally-presented information. Although people with schizophrenia (SZ) show impaired reality monitoring, nothing is known about how mood state influences this higher-order cognitive process. Accordingly, we induced positive, neutral and negative mood states to test how different mood states modulate subsequent reality monitoring performance. Our findings indicate that mood affected reality monitoring performance in HC and SZ participants in both similar and dissociable ways...
January 12, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28160752/motor-preparation-rather-than-decision-making-differentiates-parkinson-s-disease-patients-with-and-without-freezing-of-gait
#10
John S Butler, Conor Fearon, Isabelle Killane, Saskia M Waechter, Richard B Reilly, Timothy Lynch
OBJECTIVE: Freezing of gait (FOG) is a brief, episodic phenomenon affecting over half of people with Parkinson's disease (PD) and leads to significant morbidity. The pathophysiology of FOG remains poorly understood but is associated with deficits in cognitive function and motor preparation. METHOD: We studied 20 people with PD (10 with FOG, 10 without FOG) and performed a timed response target detection task while electroencephalographic data were acquired. We analysed the data to detect and examine cortical markers of cognitive decision making (P3b or centroparietal positivity, CPP) and motor readiness potential...
December 28, 2016: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28159906/identity-specific-reward-representations-in-orbitofrontal-cortex-are-modulated-by-selective-devaluation
#11
James D Howard, Thorsten Kahnt
: Goal-directed behavior is sensitive to the current value of expected outcomes. This requires independent representations of specific rewards, which have been linked to orbitofrontal cortex (OFC) function. However, the mechanisms by which the human brain updates specific goals on the fly, and translates those updates into choices, have remained unknown. Here we implemented selective devaluation of appetizing food odors in combination with pattern-based neuroimaging and a decision-making task...
February 3, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28156679/decision-support-needs-assessment-in-newly-diagnosed-malignant-glioma
#12
Camilo E Fadul, Heather Wishart
: 33 Background: Diagnosis of malignant glioma is catastrophic and standard treatment options remain non-curative. Patients are not guaranteed a good outcome, have significantly decreased QOL and exposure to risk. Shared decision making, is believed to diffuse decisional distress accompanying complex situations. METHODS: Semi-structured interviews explored patient, caregiver and physician perceptions of standard of care treatment recommendations following diagnosis...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28148556/cognitive-testing-in-patients-with-ckd-the-problem-of-missing-cases
#13
Denise Neumann, Maxi Robinski, Wilfried Mau, Matthias Girndt
BACKGROUND AND OBJECTIVES: Cognitive testing is only valid in individuals with sufficient visual and motor skills and motivation to participate. Patients on dialysis usually suffer from limitations, such as impaired vision, motor difficulties, and depression. Hence, it is doubtful that the true value of cognitive functioning can be measured without bias. Consequently, many patients are excluded from cognitive testing. We focused on reasons for exclusion and analyzed characteristics of nontestable patients...
February 1, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28146680/prefrontal-hemodynamics-of-physical-activity-and-environmental-complexity-during-cognitive-work
#14
Ryan McKendrick, Ranjana Mehta, Hasan Ayaz, Melissa Scheldrup, Raja Parasuraman
OBJECTIVE: The aim of this study was to assess performance and cognitive states during cognitive work in the presence of physical work and in natural settings. BACKGROUND: Authors of previous studies have examined the interaction between cognitive and physical work, finding performance decrements in working memory. Neuroimaging has revealed increases and decreases in prefrontal oxygenated hemoglobin during the interaction of cognitive and physical work. The effect of environment on cognitive-physical dual tasking has not been previously considered...
February 2017: Human Factors
https://www.readbyqxmd.com/read/28138316/characterizing-a-naturalistic-decision-making-phenomenon-loss-of-system-resilience-associated-with-implementation-of-new-technology
#15
Emily S Patterson, Laura G Militello, George Su, Urmimala Sarkar
We describe a phenomenon viewed through the conceptual lens of a naturalistic decision making perspective: a loss of system resilience, due to increased difficulty in performing macrocognition functions, associated with the implementation of new information technology. Examples of the phenomenon collected in a targeted literature review are characterized by stakeholder groups, technology, typical changes in workflow before and after implementation, and potential impacts on macrocognition and patient outcomes for four clinical care environments...
September 2016: Journal of Cognitive Engineering and Decision Making
https://www.readbyqxmd.com/read/28126015/cognitive-remediation-therapy-plus-behavioural-weight-loss-compared-to-behavioural-weight-loss-alone-for-obesity-study-protocol-for-a-randomised-controlled-trial
#16
Evelyn Smith, Charlotte Whittingham
BACKGROUND: Current research indicates that obese individuals have cognitive deficits in executive function, leading to difficulties with planning, impulse control and decision-making. High levels of inflammation have been proposed to contribute to executive function deficits in individuals with obesity. METHODS/DESIGN: One hundred and seventy-six obese participants will be randomly assigned to one of two groups: (1) behavioural weight loss alone (BWL) group = 8 sessions of individual BWL sessions plus 12 group BWL sessions or (2) Cognitive Remediation Therapy for Obesity (CRT-O) plus BWL group (CRT-O + BWL) = 8 sessions of individual CRT-O plus 12 group BWL sessions...
January 26, 2017: Trials
https://www.readbyqxmd.com/read/28119401/electrical-microstimulation-of-the-pulvinar-biases-saccade-choices-and-reaction-times-in-a-time-dependent-manner
#17
Adan-Ulises Dominguez-Vargas, Lukas Schneider, Melanie Wilke, Igor Kagan
: The pulvinar complex is extensively interconnected with brain regions involved in spatial processing and eye movement control. Recent inactivation studies have shown that the dorsal pulvinar plays a role in saccade target selection. However, it remains unknown whether it exerts effects on visual processing or at planning/execution stages. We employed electrical microstimulation of the dorsal pulvinar while monkeys performed saccade tasks towards instructed and freely-chosen targets...
January 24, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28117268/executive-functioning-of-sexually-compulsive-and-non-sexually-compulsive-men-before-and-after-watching-an-erotic-video
#18
Bruna Messina, Daniel Fuentes, Hermano Tavares, Carmita H N Abdo, Marco de T Scanavino
INTRODUCTION: Despite the serious behavioral consequences faced by individuals with sexual compulsivity, related neuropsychological studies are sparse. AIM: To compare decision making and cognitive flexibility at baseline and after exposure to an erotic video in sexually compulsive participants and non-sexually compulsive controls. METHODS: The sample consisted of 30 sexually compulsive men and 30 controls. Cognitive flexibility was investigated through the Wisconsin Card Sorting Test and decision making was examined through the Iowa Gambling Task...
January 20, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28116414/cognitive-training-through-mhealth-for-individuals-with-substance-use-disorder
#19
Pedro Gamito, Jorge Oliveira, Paulo Lopes, Rodrigo Brito, Diogo Morais, Cristina Caçoete, André Leandro, Teresa Almeida, Hugo Oliveira
BACKGROUND: Heroin addiction has a negative impact on cognitive functions, and even recovering addicts suffer from cognitive impairment. Recent approaches to cognitive intervention have been taking advantage of what new technologies have to offer. OBJECTIVES: We report a study testing the efficacy of a serious games approach using tablets to stimulate and rehabilitate cognitive functions in recovering addicts. METHODS: A small-scale cognitive training program with serious games was run with a sample of 14 male heroin addicts undergoing a rehabilitation program...
January 24, 2017: Methods of Information in Medicine
https://www.readbyqxmd.com/read/28114090/-pro-inflammatory-cytokines-in-alzheimer-s-disease
#20
E C Stamouli, A M Politis
Alzheimer's disease (AD), the most common progressive neurodegenerative disorder in the elderly, is clinically characterized by progressive impairment of cognitive functions, including reduced critical capacity, weakness of decision-making and problem orientation, while in the more advanced stages it is accompanied by behavioral disorders and impaired verbal ability. Neuropathological characteristics of the disease are the neurofibrillary tangles (NFT), the neuritic plaques (NP), the prominent synaptic loss and eventually the neuronal loss...
October 2016: Psychiatrikē, Psychiatriki
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