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https://www.readbyqxmd.com/read/27762121/cartap-hydrochloride-poisoning
#1
Kimmin Kalyaniwala, Kpp Abhilash, Peter John Victor
Cartap hydrochloride is a moderately hazardous nereistoxin insecticide that is increasingly used for deliberate self-harm in India. It can cause neuromuscular weakness resulting in respiratory failure. We report a patient with 4% Cartap hydrochloride poisoning who required mechanical ventilation for 36-hours. He recovered without any neurological deficits. We also review literature on Cartap hydrochloride poisoning.
August 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/26481789/fatal-diphenidol-poisoning-a-case-report-and-a-retrospective-study-of-16-cases
#2
Lin Zhang, Jinghong Ma, Shangxun Li, Rui Xue, Ming Jin, Yiwu Zhou
Diphenidol hydrochloride (DPN), a nonphenothiazinic antiemetic agent used primarily in patients with Meniere disease and labyrinthopathies to treat vomiting and vertigo, is considered to be a relatively safe drug. Since it was first approved in the United States in 1967, this drug has been widely used in Latin America and Asia and has contributed to sporadic suicidal and accidental poisonings in mainland China and Taiwan. However, its toxic or lethal concentration ranges have not yet been determined. We report a case of a 23-year-old female who suffered from DPN poisoning that resulted in death...
December 2015: Forensic Science, Medicine, and Pathology
https://www.readbyqxmd.com/read/25966266/clinical-analysis-of-penehyclidine-hydrochloride-combined-with-hemoperfusion-in-the-treatment-of-acute-severe-organophosphorus-pesticide-poisoning
#3
RANDOMIZED CONTROLLED TRIAL
M J Liang, Y Zhang
This study aimed to observe the clinical curative effect of penehyclidine hydrochloride (PHC) combined with hemoperfusion in treating acute severe organophosphorus pesticide poisoning. We randomly divided 61 patients with severe organophosphorus pesticide poisoning into an experimental group (N = 31) and a control group (N = 30), and we compared the coma-recovery time, mechanical ventilation time, healing time, hospital expenses, and mortality between the two groups. The coma-recovery time, mechanical ventilation time, and healing time were lower in the experimental group than in the control group (P < 0...
2015: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/25963705/-efficacy-of-a-fentanyl-citrate-buccal-tablet-for-esophageal-cancer-pain-management-in-a-patient-unable-to-take-oral-medication
#4
Yoshinori Fujimura, Osamu Nakahara, Shigeki Ohshima, Hideo Baba
We report a case ofa 60-year old male esophageal cancer patient who was unable to take oral medication, but was successfully treated using a fentanyl citrate buccal tablet. The patient survived a suicide attempt as a youth in which he ingested poison, but was left with a stricture of the esophagus. It became difficult for him to take nutrition orally, and he underwent an esophageal bypass operation, although he still required frequent endoscopic esophageal dilation. He subsequently presented with an anastomotic stenosis due to anastomotic leakage, and oral intake became completely impossible...
April 2015: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/25876981/-the-clinical-characteristics-of-acute-hyaroxylamine-hydrochloride-poisoning
#5
Min Zhang, Guangcai Yu, Wenjun Wang, Xiangdong Jian
No abstract text is available yet for this article.
January 2015: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/25867296/successful-use-of-therapeutic-hypothermia-after-cardiac-arrest-due-to-amitriptyline-and-venlafaxine-intoxication
#6
Terhi Kontio, Ari Salo, Teemu Kantola, Lauri Toivonen, Markus B Skrifvars
The prognosis of out-of-hospital cardiac arrest (OHCA) due to intoxication is dismal. Tricyclic antidepressants (TCAs) are widely used in the treatment of depression, but possess significant cardiotoxicity, and are one of the most common medications used in suicide attempts worldwide. TCA poisoning can cause hypotension, seizures, and cardiac conduction disturbances, which can lead to life-threatening arrhythmia. Current guidelines recommend mild therapeutic hypothermia (TH) for unconscious survivors of OHCA, but hypothermia treatment itself can cause disturbances in cardiac conduction, which could aggravate the effect of TCAs on cardiac conduction...
June 2015: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/25835774/acute-hyperkinetic-syndrome-due-to-ephedrone-abuse
#7
Anna Dolgan, Slawomir Budrewicz, Magdalena Koszewicz, Joanna Bladowska, Krzysztof Slotwinski, Mieszko Zagrajek, Ewa Koziorowska-Gawron, Ryszard Podemski
OBJECTIVES: A new form of manganese poisoning is related to the intravenous use of self-prepared methcathinone hydrochloride (ephedrone). Manganese encephalopathy typically manifests as a levodopa-resistant parkinsonism. MAIN POINTS: A 32-year-old drug-addicted man with acute gait disturbances after the ephedrone injections was presented. Choreic movements, severe postural instability, and "cock-walk" gait were observed. Magnetic resonance imaging T1 images showed high signal intensity of white matter in the basal ganglia and pituitary gland, and T2 images showed decreased signal mostly of globus pallidus with decreased N-acetylaspartate and choline levels in MR spectroscopy...
May 2015: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/25738696/differences-in-abuse-potential-of-adhd-drugs-measured-by-contrasting-poison-centre-and-therapeutic-use-data
#8
Louise Schow Jensen, Anne Katrine Pagsberg, Kim Peder Dalhoff
CONTEXT: Atomoxetine (ATX) is the treatment of choice for attention deficit hyperactivity disorders with co-morbid risk of drug abuse, although its abuse potential needs to be qualified. The purpose of this study is to analyse ATX misuse in relation to therapeutic use and compare our results with that of methylphenidate (MPH). METHODS AND MATERIALS: Data on enquiries were extracted from the Danish Poison Information Centre database (January 2006 to June 2012), while data on therapeutic use were provided by the Danish State Serum Institute (2007-2011)...
May 2015: Clinical Toxicology
https://www.readbyqxmd.com/read/25542453/clinical-management-of-organophosphate-poisoning-in-pregnancy
#9
Liang Sun, Guo-qiang Li, Peng-bo Yan, Yang Liu, Guo-feng Li, Lu-Qing Wei
BACKGROUND: Acute organophosphorus pesticide poisoning during pregnancy may lead to spontaneous abortion. Now, there is no definite strategy focused on maintaining pregnancy. METHOD: This is a retrospective analysis of 2 cases of organophosphorus poisoning during pregnancy. All patients received penehyclidine hydrochloride injection,until the tracheobronchial tree is cleared of the secretions, and most secretions were dried. In addition, magnesium sulfate was used in one woman for the correction of hyperdynamic uterine activity...
February 2015: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/25086830/distribution-of-venlafaxine-and-o-desmethylvenlafaxine-in-a-fatal-case
#10
Claudia Vignali, Luca Morini, Yao Chen, Cristiana Stramesi, Angelo Groppi
Venlafaxine is an extensively used antidepressant drug; it is considered to be quite safe and only a few pure cases of fatal poisoning have been reported. Here we describe a fatal case of venlafaxine self-poisoning including detailed tissue distribution of the drug and its metabolite O-desmethylvenlafaxine and the exact time sequence of events, as reported in the patient's clinical record. Qualitative analyses were performed by GC-MS while quantitative analyses were carried out by LC-MS/MS. We then compared our results with those of previously published cases...
September 2014: Forensic Science International
https://www.readbyqxmd.com/read/24667730/enhanced-adult-neurogenesis-increases-brain-stiffness-in-vivo-magnetic-resonance-elastography-in-a-mouse-model-of-dopamine-depletion
#11
Charlotte Klein, Elisabeth G Hain, Juergen Braun, Kerstin Riek, Susanne Mueller, Barbara Steiner, Ingolf Sack
The mechanical network of the brain is a major contributor to neural health and has been recognized by in vivo magnetic resonance elastography (MRE) to be highly responsive to diseases. However, until now only brain softening was observed and no mechanism was known that reverses the common decrement of neural elasticity during aging or disease. We used MRE in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride (MPTP) mouse model for dopaminergic neurodegeneration as observed in Parkinson's disease (PD) to study the mechanical response of the brain on adult hippocampal neurogenesis as a robust correlate of neuronal plasticity in healthy and injured brain...
2014: PloS One
https://www.readbyqxmd.com/read/24636552/charcoal-hemoperfusion-in-bupropion-overdose
#12
Hızır Ufuk Akdemir, Fatih Calışkan, Latif Duran, Celal Katı, Bülent Güngörer, Metin Ocak
Bupropion is a relatively new and popular medication for depression, with seizures as its major side effect. In the literature, there are insufficient data about hemodialysis following bupropion overdose. A 23-year-old female patient was brought to our emergency department with acute change in mental status and seizure after deliberate self-poisoning with approximately 25-30 tablets of bupropion hydrochloride. Her Glasgow coma scale score was 8/15. The patient underwent hemodialysis about 4 hours later. After 4 hours of extracorporeal treatment, she became conscious and was extubated...
October 2014: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/24607076/a-double-blind-randomized-study-to-assess-the-validity-of-applied-kinesiology-ak-as-a-diagnostic-tool-and-as-a-nonlocal-proximity-effect
#13
RANDOMIZED CONTROLLED TRIAL
Stephan A Schwartz, Jessica Utts, S James P Spottiswoode, Christopher W Shade, Lisa Tully, William F Morris, Ginette Nachman
PREMISE: Applied Kinesiology (AK) is a diagnostic technique widely used within the Integrative Medical community. In essence, it posits that a question can be mentally held in a person's mind, sometimes while they are holding a substance like a vitamin, or a food sample, and by measuring relative muscular weakness an answer as to whether the substance or the condition represented by the question is good for that person can be obtained. This AK is presumed to have a diagnostic capability...
March 2014: Explore: the Journal of Science and Healing
https://www.readbyqxmd.com/read/24342326/protective-effects-of-penehyclidine-hydrochloride-on-acute-lung-injury-caused-by-severe-dichlorvos-poisoning-in-swine
#14
Juan Cui, Chun-Sheng Li, Xin-Hua He, Yu-Guo Song
BACKGROUND: Organophosphate poisoning is an important health problem in developing countries which causes death mainly by inducing acute lung injury. In this study, we examined the effects of penehyclidine hydrochloride (PHC), a selective M-receptor inhibitor, on dichlorvos-induced acute lung injury in swine. METHODS: Twenty-two female swines were randomly divided into control (n = 5), dichlorvos (n = 6), atropine (n = 6), and PHC (n = 5) groups. Hemodynamic data, extravascular lung water index (EVLWI), and pulmonary vascular permeability index (PVPI) were monitored; blood gas analysis and acetylcholinesterase (AchE) levels were measured...
2013: Chinese Medical Journal
https://www.readbyqxmd.com/read/24021536/capacities-of-metabotropic-glutamate-modulators-in-counteracting-soman-induced-seizures-in-rats
#15
Trond Myhrer, Espen Mariussen, Siri Enger, Pål Aas
Current treatment of nerve agent poisoning with ionotropic drugs proves inadequate, and alternative treatment strategies are searched for. Based on positive findings with metabotropic glutamate modulators in microinfusion studies, the present study was initiated to examine anticonvulsant effects of MPEP (2-Methyl-6-(phenylethynyl)pyridine hydrochloride), a metabotropic glutamate receptor 5 antagonist, and DCG-IV ((2S,2'R,3'R)-2-(2',3'-dicarboxycyclopropyl)glycine), a metabotropic glutamate receptor 2/3 agonist, when administered systemically in combinations with HI-6 (1-[([4-(aminocarbonyl)pyridino]methoxy)methyl]-2-[(hydroxyimino)methyl]pyridinium) and procyclidine or HI-6 and levetiracetam relative to the combination of HI-6, procyclidine, and levetiracetam...
October 15, 2013: European Journal of Pharmacology
https://www.readbyqxmd.com/read/23803548/-clinical-efficacy-of-ulinastatin-combined-with-penehyclidine-hydrochloride-in-prevention-and-treatment-of-highly-irritant-gas-poisoning
#16
RANDOMIZED CONTROLLED TRIAL
Yu-fa Liu, Li-jun Su, Cui-lan Zhou
No abstract text is available yet for this article.
June 2013: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/23791468/combined-treatment-of-methylprednisolone-pulse-and-memantine-hydrochloride-prompts-recovery-from-neurological-dysfunction-and-cerebral-hypoperfusion-in-carbon-monoxide-poisoning-a-case-report
#17
Konosuke Iwamoto, Ken Ikeda, Sunao Mizumura, Kazuhiro Tachiki, Masaru Yanagihashi, Yasuo Iwasaki
A 49-year-old healthy man developed sudden unconsciousness under inadequate ventilation. Blood gas analysis showed carboxyhemoglobin of 7.3%. After normobaric oxygen therapy, he recovered completely 7 days later. At 3 weeks after carbon monoxide (CO) exposures, memory and gait disturbances appeared. Neurological examination revealed Mini-Mental State Examination (MMSE) score of 5 of 30 points, leg hyper-reflexia with Babinski signs, and Parkinsonism. Brain fluid-attenuated inversion recovery imaging disclosed symmetric hypointense lesions in the thalamus and the globus pallidus, and hyperintense lesions in the cerebral white matter...
March 2014: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/23774520/2-4-dichlorophenol-induces-apoptosis-in-primary-hepatocytes-of-grass-carp-ctenopharyngodon-idella-through-mitochondrial-pathway
#18
Hui Li, Xiaoning Zhang, Qian Qiu, Zhen An, Yongmei Qi, Dejun Huang, Yingmei Zhang
2,4-Dichlorophenol (2,4-DCP), a major type of chlorophenols, has been widely used to produce some herbicides and pharmaceuticals, yet due to its incomplete degradation and bioaccumulation characteristics, it is toxic to aquatic organisms. Apoptosis is one of the most severe outcomes of cell poisoning and injury. So far, the potential molecular mechanism of 2,4-DCP-induced apoptosis has not been reported. This study showed that 2,4-DCP significantly induced apoptosis in primary hepatocytes of grass carp (Ctenopharyngodon idella)...
September 15, 2013: Aquatic Toxicology
https://www.readbyqxmd.com/read/23413571/synthesis-antifungal-activity-and-structure-activity-relationships-of-vanillin-oxime-n-o-alkanoates
#19
Vivek Ahluwalia, Nandini Garg, Birendra Kumar, Suresh Walia, Om P Sati
Vanillin oxime-N-O-alkanoates were synthesized following reaction of vanillin with hydroxylamine hydrochloride, followed by reaction of the resultant oxime with acyl chlorides. The structures of the compounds were confirmed by IR, 1H, 13C NMR and mass spectral data. The test compounds were evaluated for their in vitro antifungal activity against three phytopathogenic fungi Macrophomina phaseolina, Rhizoctonia solani and Sclerotium rolfsii by the poisoned food technique. The moderate antifungal activity of vanillin was slightly increased following its conversion to vanillin oxime, but significantly increased after conversion of the oxime to oxime-N-O-alkanoates...
December 2012: Natural Product Communications
https://www.readbyqxmd.com/read/23376588/pro-inflammatory-cytokines-modulate-iron-regulatory-protein-1-expression-and-iron-transportation-through-reactive-oxygen-nitrogen-species-production-in-ventral-mesencephalic-neurons
#20
Jia Wang, Ning Song, Hong Jiang, Jun Wang, Junxia Xie
Both inflammatory processes associated with microglia activation and abnormal iron deposit in dopaminergic neurons are involved in the pathogenesis of Parkinson's disease (PD). However, the relationship between neuroinflammation and iron accumulation was not fully elucidated. In the present study, we aimed to investigate whether the pro-inflammatory cytokines interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) released by microglia, could affect cellular iron transportation in primary cultured ventral mesencephalic (VM) neurons...
May 2013: Biochimica et Biophysica Acta
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