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https://www.readbyqxmd.com/read/28454060/heated-humidified-high-flow-nasal-cannula-oxygen-after-thoracic-surgery-a-randomized-prospective-clinical-pilot-trial
#1
Jason Brainard, Benjamin K Scott, Breandan L Sullivan, Ana Fernandez-Bustamante, Jerome R Piccoli, Morris G Gebbink, Karsten Bartels
BACKGROUND: Thoracic surgery patients are at high-risk for adverse pulmonary outcomes. Heated humidified high-flow nasal cannula oxygen (HHFNC O2) may decrease such events. We hypothesized that patients randomized to prophylactic HHFNC O2 would develop fewer pulmonary complications compared to conventional O2 therapy. METHODS AND PATIENTS: Fifty-one patients were randomized to HHFNC O2 vs. conventional O2. The primary outcome was a composite of postoperative pulmonary complications...
April 19, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28453646/protecting-confidentiality-in-cancer-registry-data-with-geographic-identifiers
#2
Mandi Yu, Jerome Phillip Reiter, Li Zhu, Benmei Liu, Kathleen A Cronin, Eric J Rocky Feuer
The National Cancer Institute's Surveillance, Epidemiology, and End Results Program releases research files of cancer registry data. These files include geography at the county level, but no finer. Access to finer geography, such as tract identifiers, would enable richer analyses, for example, examination of health disparities across neighborhoods. To date, tract identifiers are left off the research files because they could compromise the confidentiality of patients' identities. We present an approach to include tract identifiers based on multiply-imputed, synthetic data...
April 27, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28453575/genome-wide-association-study-of-red-blood-cell-traits-in-hispanics-latinos-the-hispanic-community-health-study-study-of-latinos
#3
Chani J Hodonsky, Deepti Jain, Ursula M Schick, Jean V Morrison, Lisa Brown, Caitlin P McHugh, Claudia Schurmann, Diane D Chen, Yong Mei Liu, Paul L Auer, Cecilia A Laurie, Kent D Taylor, Brian L Browning, Yun Li, George Papanicolaou, Jerome I Rotter, Ryo Kurita, Yukio Nakamura, Sharon R Browning, Ruth J F Loos, Kari E North, Cathy C Laurie, Timothy A Thornton, Nathan Pankratz, Daniel E Bauer, Tamar Sofer, Alex P Reiner
Prior GWAS have identified loci associated with red blood cell (RBC) traits in populations of European, African, and Asian ancestry. These studies have not included individuals with an Amerindian ancestral background, such as Hispanics/Latinos, nor evaluated the full spectrum of genomic variation beyond single nucleotide variants. Using a custom genotyping array enriched for Amerindian ancestral content and 1000 Genomes imputation, we performed GWAS in 12,502 participants of Hispanic Community Health Study and Study of Latinos (HCHS/SOL) for hematocrit, hemoglobin, RBC count, RBC distribution width (RDW), and RBC indices...
April 28, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28449274/a-dna-barcode-library-for-germany-s-mayflies-stoneflies-and-caddisflies-ephemeroptera-plecoptera-trichoptera
#4
Jérôme Morinière, Lars Hendrich, Michael Balke, Arne J Beermann, Tobias König, Monika Hess, Stefan Koch, Reinhard Müller, Florian Leese, Paul D N Hebert, Axel Hausmann, Christoph F Schubart, Gerhard Haszprunar
Mayflies, stoneflies and caddisflies (Ephemeroptera, Plecoptera and Trichoptera) are prominent representatives of aquatic macroinvertebrates, commonly used as indicator organisms for water quality and ecosystem assessments. However, unambiguous morphological identification of EPT species, especially their immature life stages, is a challenging, yet fundamental task. However, a comprehensive DNA barcode library based upon taxonomically well-curated specimens can overcome the problematic identification. Once available, this library will support the implementation of fast, cost-efficient, and reliable DNA-based identifications and assessments of ecological status...
April 27, 2017: Molecular Ecology Resources
https://www.readbyqxmd.com/read/28447870/does-specialized-inpatient-rehabilitation-affect-whether-or-not-people-with-traumatic-spinal-cord-injury-return-home
#5
Christiana L Cheng, Tova Plashkes, Tian Shen, Nader Fallah, Suzanne Humphreys, Colleen O'Connell, A Gary Linassi, Chester Ho, Christine Short, Karen Ethans, Rebecca Charbonneau, Jérôme Paquet, Vanessa K Noonan
Return to living at home is an important patient-reported outcome following traumatic spinal cord injury (tSCI). Specialized inpatient rehabilitation assists such patients in maximizing function and independence. Our project aim was to describe those patients receiving specialized rehabilitation after tSCI in Canada, and to determine if such rehabilitation improved the likelihood of returning home. This cohort study utilized data from RHSCIR to identify patients with tSCI discharged from 1 of 18 participating acute specialized spine facilities between 2011-2015 to either 1 of 13 participating specialized rehabilitation facilities, or another discharge destination...
April 27, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28447840/the-rational-status-of-quantum-cognition
#6
Emmanuel M Pothos, Jerome R Busemeyer, Richard M Shiffrin, James M Yearsley
Classic probability theory (CPT) is generally considered the rational way to make inferences, but there have been some empirical findings showing a divergence between reasoning and the principles of classical probability theory (CPT), inviting the conclusion that humans are irrational. Perhaps the most famous of these findings is the conjunction fallacy (CF). Recently, the CF has been shown consistent with the principles of an alternative probabilistic framework, quantum probability theory (QPT). Does this imply that QPT is irrational or does QPT provide an alternative interpretation of rationality? Our presentation consists of 3 parts...
April 27, 2017: Journal of Experimental Psychology. General
https://www.readbyqxmd.com/read/28447689/chemodynamics-of-metal-ion-complexation-by-charged-nanoparticles-a-dimensionless-rationale-for-soft-core-shell-and-hard-particle-types
#7
Jérôme F L Duval
Soft nanoparticulate complexants are defined by a spatial confinement of reactive sites and electric charges inside their 3D body. In turn, their reactivity with metal ions differs significantly from that of simple molecular ligands. A revisited form of the Eigen mechanism recently elucidated the processes leading to metal/soft particle pair formation. Depending on e.g. particle size and metal ion nature, chemodynamics of nanoparticulate metal complexes is controlled by metal conductive diffusion to/from the particles, by intraparticulate complex formation/dissociation kinetics, or by both...
April 27, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28446434/donor-engrafted-chip-is-common-among-stem-cell-transplant-recipients-with-unexplained-cytopenias
#8
Christopher J Gibson, James A Kennedy, Sarah Nikiforow, Frank C Kuo, Edwin P Alyea, Vincent Ho, Jerome Ritz, Robert Soiffer, Joseph H Antin, R Coleman Lindsley
No abstract text is available yet for this article.
April 26, 2017: Blood
https://www.readbyqxmd.com/read/28446341/decarboxylative-alkynylation-and-cyanation-of-carboxylic-acids-using-photoredox-catalysis-and-hypervalent-iodine-reagents
#9
Franck Le Vaillant, Jérôme Waser
Alkynes and nitriles are important functional groups that serve as versatile building blocks in organic synthesis and find applications in material and medicinal sciences. A convenient and straightforward access to both classes of compounds under mild conditions is, therefore, highly desirable. Herein, we disclose the decarboxylative alkynylation and cyanation of broadly available carboxylic acids using photoredox catalysis and hypervalent iodine reagents. Choices of both catalysts and reagents were crucial...
April 26, 2017: Chimia
https://www.readbyqxmd.com/read/28445792/vitamin-d-supplementation-restores-the-blunted-muscle-protein-synthesis-response-in-deficient-old-rats-through-an-impact-on-ectopic-fat-deposition
#10
Audrey Chanet, Jérôme Salles, Christelle Guillet, Christophe Giraudet, Alexandre Berry, Véronique Patrac, Carla Domingues-Faria, Camille Tagliaferri, Katia Bouton, Justine Bertrand-Michel, Miriam Van Dijk, Marion Jourdan, Yvette Luiking, Sjors Verlaan, Corinne Pouyet, Philippe Denis, Yves Boirie, Stéphane Walrand
We investigated the impact of vitamin D deficiency and repletion on muscle anabolism in old rats. Animals were fed a control (1 IU vitamin D3/g, ctrl, n=20) or a vitamin D-depleted diet (VDD; 0 IU, n=30) for 6 months. A subset was thereafter sacrificed in the control (ctrl6) and depleted groups (VDD6). Remaining control animals were kept for 3 additional months on the same diet (ctrl9), while a part of VDD rats continued on a depleted diet (VDD9) and another part was supplemented with vitamin D (5 IU, VDS9)...
April 8, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28445349/surgical-determinants-of-patient-reported-outcomes-following-postmastectomy-reconstruction-in-women-with-breast-cancer
#11
Ranjeet Jeevan, John P Browne, Carmel Gulliver-Clarke, Jerome Pereira, Christopher M Caddy, Jan H P van der Meulen, David A Cromwell
BACKGROUND: This national prospective cohort study compared the patient-reported outcomes of breast cancer patients undergoing postmastectomy autologous reconstruction to those who had breast implants, in terms of aesthetic appearance; levels of psychological, physical, and sexual well-being; and overall satisfaction. METHODS: Of 5063 women who underwent immediate reconstruction (n = 3349) or delayed reconstruction (n = 1714) between January 1, 2008, and March 31, 2009, in England, 2923 women who gave informed consent were sent validated, procedure-specific, 18-month follow-up questionnaires...
May 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28444298/the-line-drawing-problem-in-disease-definition
#12
Wendy A Rogers, Mary Jean Walker
Biological dysfunction is regarded, in many accounts, as necessary and perhaps sufficient for disease. But although disease is conceptualized as all-or-nothing, biological functions often differ by degree. A tension is created by attempting to use a continuous variable as the basis for a categorical definition, raising questions about how we are to pinpoint the boundary between health and disease. This is the line-drawing problem. In this paper, we show how the line-drawing problem arises within "dysfunction-requiring" accounts of disease, such as those of Christopher Boorse and Jerome Wakefield...
April 21, 2017: Journal of Medicine and Philosophy
https://www.readbyqxmd.com/read/28444159/a-strange-nature-of-right-ventricular-tumour-the-first-case-report-of-osseous-metaplasia-in-the-heart
#13
Jérôme Corré, Stephan Chassaing, Olivier Lepage, Didier Blanchard
No abstract text is available yet for this article.
April 24, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28443846/on-chip-enzymatic-microbiofuel-cell-powered-integrated-circuits
#14
Andrew G Mark, Emmanuel Suraniti, Jérôme Roche, Harald Richter, Alexander Kuhn, Nicolas Mano, Peer Fischer
A variety of diagnostic and therapeutic medical technologies rely on long term implantation of an electronic device to monitor or regulate a patient's condition. One proposed approach to powering these devices is to use a biofuel cell to convert the chemical energy from blood nutrients into electrical current to supply the electronics. We present here an enzymatic microbiofuel cell whose electrodes are directly integrated into a digital electronic circuit. Glucose oxidizing and oxygen reducing enzymes are immobilized on microelectrodes of an application specific integrated circuit (ASIC) using redox hydrogels to produce an enzymatic biofuel cell, capable of harvesting electrical power from just a single droplet of 5 mM glucose solution...
April 26, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28441518/learning-to-allocate-limited-time-to-decisions-with-different-expected-outcomes
#15
Arash Khodadadi, Pegah Fakhari, Jerome R Busemeyer
The goal of this article is to investigate how human participants allocate their limited time to decisions with different properties. We report the results of two behavioral experiments. In each trial of the experiments, the participant must accumulate noisy information to make a decision. The participants received positive and negative rewards for their correct and incorrect decisions, respectively. The stimulus was designed such that decisions based on more accumulated information were more accurate but took longer...
April 19, 2017: Cognitive Psychology
https://www.readbyqxmd.com/read/28440654/holocene-atmospheric-mercury-levels-reconstructed-from-peat-bog-mercury-stable-isotopes
#16
Maxime Enrico, Gael Le Roux, Lars-Eric Heimburger, Pieter Van Beek, Marc Souhaut, Jerome Chmeleff, Jeroen E Sonke
Environmental regulations on mercury (Hg) emissions and associated ecosystem restoration are closely linked to what Hg levels we consider natural. It is widely accepted that atmospheric Hg deposition has increased by a factor 3±1 since pre-industrial times. However, no long-term historical records of actual atmospheric gaseous elemental Hg (GEM) concentrations exist. In this study we report Hg stable isotope signatures in Pyrenean peat records (southwestern Europe) that are used as tracers of Hg deposition pathway (Δ(200)Hg, wet vs dry Hg deposition) and atmospheric Hg sources and cycling (δ(202)Hg, Δ(199)Hg)...
April 25, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28440050/enzymatic-debridement-with-collagenase-in-wounds-and-ulcers-a-systematic-review-and-meta-analysis
#17
Jérôme Patry, Virginie Blanchette
Enzymatic debridement with collagenase is a technique that is commonly used in clinical practice. This systematic review examines the effect of collagenase on all kinds of wounds, compared to an alternative therapy, on wound healing, wound bed characteristics, cost-effectiveness and the occurrence of adverse events. We conducted a systematic literature search on available literature in Cochrane databases, MEDLINE, EMBASE and CINAHL. Two investigators independently assessed the titles and abstracts of all randomised controlled trials obtained involving collagenase of all kinds of wounds based on inclusion criteria...
April 25, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28439649/differences-in-tibial-subchondral-bone-structure-evaluated-using-plain-radiographs-between-knees-with-and-without-cartilage-damage-or-bone-marrow-lesions-the-oulu-knee-osteoarthritis-study
#18
Jukka Hirvasniemi, Jérôme Thevenot, Ali Guermazi, Jana Podlipská, Frank W Roemer, Miika T Nieminen, Simo Saarakkala
OBJECTIVES: To investigate whether subchondral bone structure from plain radiographs is different between subjects with and without articular cartilage damage or bone marrow lesions (BMLs). METHODS: Radiography-based bone structure was assessed from 80 subjects with different stages of knee osteoarthritis using entropy of Laplacian-based image (ELap) and local binary patterns (ELBP), homogeneity index of local angles (HIAngles,mean), and horizontal (FDHor) and vertical fractal dimensions (FDVer)...
April 24, 2017: European Radiology
https://www.readbyqxmd.com/read/28438779/human-alternative-macrophages-populate-calcified-areas-of-atherosclerotic-lesions-and-display-impaired-rankl-induced-osteoclastic-bone-resorption-activity
#19
Giulia Chinetti-Gbaguidi, Mehdi Daoudi, Mickael Rosa, Manjula Vinod, Loïc Louvet, Corinne Copin, Melanie Fanchon, Jonathan Vanhoutte, Bruno Derudas, Loic Belloy, Stephan Haulon, Christophe Zawadzki, Sophie Susen, Ziad A Massy, Jérôme Eeckhoute, Bart Staels
Rationale: Vascular calcification is a process similar to bone formation leading to an inappropriate deposition of calcium phosphate minerals in advanced atherosclerotic plaques. Monocyte-derived macrophages, located in atherosclerotic lesions and presenting heterogeneous phenotypes, from classical pro-inflammatory M1 to alternative anti-inflammatory M2 macrophages, could potentially display osteoclast-like functions. Objective: To characterize the phenotype of macrophages located in areas surrounding the calcium deposits in human atherosclerotic plaques...
April 24, 2017: Circulation Research
https://www.readbyqxmd.com/read/28438569/methylprednisolone-liver-toxicity-a-new-case-and-a-french-regional-pharmacovigilance-survey
#20
Jérôme Dumortier, Judith Cottin, Caroline Lavie, Olivier Guillaud, Valérie Hervieu, Christine Chambon-Augoyard, Jean-Yves Scoazec, Sandra Vukusic, Thierry Vial
Reported hepatotoxicity induced by corticosteroids is very rare, and the diagnosis is highly challenging in the context of auto-immune disease. We report here a case of high-dose methylprednisolone (MP)-induced acute hepatitis confirmed by liver histology in a patient with multiple sclerosis (MS) and a case series (n=4) notified to the French Pharmacovigilance center of Lyon. In all 5 cases, other common causes of hepatitis were excluded. The causal relationship with MP pulse therapy was supported by the fact that MP was the only culprit drug...
April 21, 2017: Clinics and Research in Hepatology and Gastroenterology
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