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Tara Linseman, Sébastien Soubeyrand, Amy Martinuk, Majid Nikpay, Paulina Lau, Ruth McPherson
BACKGROUND: Although virtually all coronary artery disease associated single-nucleotide polymorphisms identified by genome-wide association studies (GWAS) are in noncoding regions of the genome, a common polymorphism in ZC3HC1 (rs11556924), resulting in an arginine (Arg) to histidine (His) substitution in its encoded protein, NIPA (Nuclear Interacting Partner of Anaplastic Lyphoma Kinase) is linked to a protection from coronary artery disease. NIPA plays a role in cell cycle progression, but the functional consequences of this polymorphism have not been established...
January 2017: Circulation. Cardiovascular Genetics
W Chen, X Xu
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
Wenyan Yang, Fuguang Sun, Hongjun Liu, Guangjian Wang, Peiqing Shi, Zhiqiang Shao, Fengfu Guo
Increasing numbers of extrapleural solitary fibrous tumours (SFTs), including the prostate SFT, have been reported over the last 10-years. Prostate SFT is relatively uncommon, with <20 cases reported in the literature worldwide. In the present study, a prostate SFT case, which was initially misdiagnosed as benign prostatic hyperplasia, is presented. The patient was subjected to three surgeries (cystoscopy and per urethra lithocystotomy, transurethral resection of the prostate and nerve-sparing retropubic radical prostatectomy) prior to SFT diagnosis...
September 2015: Oncology Letters
Qiuyan Wang, Shaoling Wu, Xindong Zhao, Chunting Zhao, Hongguo Zhao, Lanfen Huo
The validated therapeutic effects of dihydroartemisinin (DHA) in solid tumors have encouraged us to explore its potential in treating T-cell lymphoma. We found that Jurkat cells (a T-cell lyphoma cell line) were sensitive to DHA treatment with a IC50 of dihydroartemisinin. The cytotoxic effect of DHA in Jurkat cells showed a dose- and time- dependent manner. Interestingly, the cytotoxic effect of DHA was further enhanced by holotransferrin (HTF) due to the high expression of transferrin receptors in T-cell lymphoma...
2015: PloS One
Małgorzata Sokołowska-Wojdyło, Magdalena Trzeciak, Jadwiga Roszkiewicz
The primary cutaneous lymphomas are often indolent but difficult to treat. In the early stages psoralen and ultraviolet-A therapy is the standard treatment whereas at the tumor stage chemotherapy (e.g. pegylated doxorubicin) is often used for debulking. The purine analog 2-chlorodeoxyadenosine (2CdA) acts in non-Hodgkin's lymphoma and has been used in our center for the treatment of advanced primary cutaneous T-cell lyphomas (CTCL). Here, we report on the efficacy and side effects of 2CdA in six patients with CTCL...
August 31, 2010: Dermatology Reports
Serdar Sivgin, Esen Karakus, Leylagul Kaynar, Fatih Kurnaz, Cigdem Pala, Muzaffer Keklik, Gokmen Zararsiz, Musa Solmaz, Bulent Eser, Mustafa Cetin, Ali Unal
OBJECTIVES AND AIM: Patients affected by hematological malignancies can often benefit from high dose chemotherapy followed by peripheral blood stem cells (PBSCs) transplantation. Different strategies have been used to mobilize an adequate number of PBSC, including granulocyte colony-stimulating factor (G-CSF) alone or chemotherapy plus G-CSF. In this study, we aimed to compare the efficacy profile of different G-CSF agents including filgrastim (Neupogen®), biosimilar filgrastim (Leucostim®) and Lenograstim (Granocyte®) on CD34(+) mobilization in patients who underwent autologous hematopoietic stem cell transplantation (autoHSCT)...
June 2013: Transfusion and Apheresis Science
Xueping Xie, Ruozhi Zhao, Garry X Shen
Elevated levels of glycated low density lipoprotein (glyLDL) are frequently detected in diabetic patients. Previous studies demonstrated that glyLDL increased the production of reactive oxygen species (ROS), activated NADPH oxidase (NOX) and suppressed mitochondrial electron transport chain (mETC) enzyme activities in vascular endothelial cells (EC). The present study examined the effects of cyanidin-3-glucoside (C3G), a type of anthocyanin abundant in dark-skinned berries, on glyLDL-induced ROS production, NOX activation and mETC enzyme activity in porcine aortic EC (PAEC)...
2012: International Journal of Molecular Sciences
Pierluigi Cocco, Giannina Satta, Ileana D'Andrea, Tinucia Nonne, Giuseppe Udas, Mariagrazia Zucca, Andrea 't Mannetje, Nikolaus Becker, Silvia de Sanjosé, Lenka Foretova, Anthony Staines, Marc Maynadié, Alexandra Nieters, Paul Brennan, Maria G Ennas, Paolo Boffetta
We explored the risk of lymphoma and its most prevalent subtypes associated with occupational contact with livestock, and whether risk was modified by age at first contact, in 2,348 incident lymphoma cases and 2,462 controls who participated in the EPILYMPH case-control study. A detailed occupational history was collected in cases and controls, including working in a livestock farm, species of livestock, its approximate number and circumstances of contact. For each disease outcome, and each type of livestock, odds ratios (OR) and their 95% confidence intervals (95% CI) were calculated using unconditional logistic regression, adjusting for age, gender, education and center...
June 1, 2013: International Journal of Cancer. Journal International du Cancer
Nezihi Kucukarslan, Tolga Tatar, Mehmet Uzun, Izzet Yavuz, Ertugrul Ozal, Harun Tatar
BACKGROUND: There is debate on the timing and outcome of coronary artery bypass surgery in patients with coincident malignancy. In this study, we compared the outcome of coronary artery bypass graft (CABG) in such patients with those without malignancy. METHODS: The patients were selected from those who had undergone coronary artery bypass surgery in the last decade. The study group (group I) included the patients with malignancy in remission. The control group comprised those patients who were selected randomly from those without any malignancy...
March 2009: Journal of Cardiac Surgery
U Kolyvanos Naumann, L Käser, W Vetter
No abstract text is available yet for this article.
October 18, 2006: Praxis
W Fischbach
In extranodal non-Hodgkin's lymphoma (NHL), the gastrointestinal tract is by far the most frequent localization. One must differentiate between primary lymphoma, e.g. those arising in the gastrointestinal tract, and secondary lymphoma, which can affect the digestive tract as a disseminations of nodal lymphoma. Analysis of histomorphologic and immunhistochemical characteristics and the concept of mucosa-associated lymphoid tissue (MALT) have led to primary gastrointestinal lymphoma now being viewed as an independent entity...
June 2006: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
Türkan Tansel, Ertan Onursal, Enver Dayloğlu, Murat Başaran, Zerrin Sungur, Emre Qamci, Dilek Yilmazbayhan, Rukiye Eker, Türkan Ertuğrul
We reviewed all cases of primary pediatric mediastinal masses diagnosed and treated over a 24-year period. In this study, out of 187 primary mediastinal mass cases diagnosed between 1980 and 2004 in Istanbul University Istanbul Faculty of Medicine, Cardiovascular Surgery Department, 37 pediatric primary mediastinal mass cases were retrospectively evaluated according to age, sex, symptoms, diagnostic procedure, anatomical location, surgical treatment, histopathological evaluation and postoperative adjuvant therapy...
January 2006: Turkish Journal of Pediatrics
D de Jong, J Bosq, K A MacLennan, J Diebold, J Audouin, J Chasle, A-M Mandard, J Marnay, M Henry-Amar
BACKGROUND: To investigate the proportion, clinical characteristics and outcome of lymphocyte-rich classical Hodgkin lymphoma (LRCHL) in relation to nodular lymphocyte predominant HL (NLPHL) and classical HL (cHL). PATIENTS AND METHODS: A series of 2743 HL patients of all stages enrolled into three EORTC trials (H7, H8, H34) conducted between 1988 and 2000 and forming an unbiased series of HL patients was studied. RESULTS: Detailed histological classification after panel review was available in 96% of the cases to allow selection of all cases with features potentially compatible with the WHO-definition of LRCHL for this study...
January 2006: Annals of Oncology: Official Journal of the European Society for Medical Oncology
Michael E Williams
No abstract text is available yet for this article.
December 2003: Clinical Advances in Hematology & Oncology: H&O
Xi-Ping Ding, Jun-Yu Wang, Xian-Rui Yuan, Ze-Feng Peng
OBJECTIVE: To analyze the clinical and neuroimage characteristics of primary central nervous system lymphoma and explore the methods of treatment. METHODS: The clinical data of 28 cases of primary central nervous system lymphoma were analyzed retrospectively. RESULTS: All the 28 patients with lyphoma were proved by craniotomy and pathologic study. The survival periods were 5 days to 40 months after the craniotomy. Eighteen patients received radiotherapy after the operation...
August 2004: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
Ali Borazan, Hasan Ustün, Samil Ecirli
This report describes a non-Hodgkin lyphoma case presenting with skeletal muscle and cutaneous involvement. A 75 year-old man was admitted to hospital with mass in the right upper extremity and skin lesions on the back of his trunk. Excisional mass biopsy was reported immunohistopthologically as large B-cell lymphoma. Primary extranodal lymphoma arising from skeletal muscle and concomitant skin infiltration of other body localization is not common. So this case was represented and relevant literature was reviewed...
2003: Acta Medica (Hradec Králové)
A Wang, Y Luo, Z Wang
OBJECTIVE: To assess the optinums chemotherapeutic protocols for higher CR rate in the treatment of intermediate and high grade malignant non Hodgin's lyphoma(NHL). METHODS: Seventy-four patients with pathological intermediate and high grade malignant NHL were tried randomly with revised ProMACE-CytaBOM(treatment group) and CHOP(control group). RESULTS: The CR rate was 56.8% in the treatment group and 35.0% in the control group (P > 0.05)...
May 1997: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
J W Sweetenham, P F Smartt, B S Wilkins, J C Pellatt, J L Smith, A Ramsay, J M Whitehouse
BACKGROUND: The clinical applicability of the Revised European-American Lymphoma (R.E.A.L.) Classification has been demonstrated in several retrospective studies. The present, ongoing study was initiated to evaluate the clinical and pathological utility of the R.E.A.L. Classification compared with the Working Formulation (WF) in a prospective fashion, in an unselected patient population treated at a single institution. PATIENTS AND METHODS: Prospective data were collected on 596 biopsies from 557 patients referred with an initial diagnosis of lymphoma...
September 1999: Annals of Oncology: Official Journal of the European Society for Medical Oncology
M Basu, S A Weng, H Tang, F Khan, F Rossi, S Basu
The galactosyltransferase, GalT-4, which catalyses the biosynthesis in vitro of neolactotetraosylceramide, nLcOse4Cer (Gal beta 1-4GlcNAc beta 1-3Gal beta 1-4Glc-Cer) from lactotriaosylceramide, LcOse3Cer (Glc NAc beta 1-3Gal beta 1-4Glc-Cer), and UDP-galactose has been purified 107 500-fold from a mineral oil induced mouse T-lyphoma P-1798, using affinity columns. The purified enzyme is partially stabilized in the presence of phospholipid liposomes. Two closely migrating protein bands of apparent molecular weights 56 kDa and 63 kDa were observed after sodium dodecyl sulfate polyacrylamide gel electrophoresis of highly purified mouse GalT-4...
June 1996: Glycoconjugate Journal
I Shah, G Doelken, H Hartleitner, W Sandritter
We present the first case of Lennert's Lymphoma in which cytophotometric determinations for DNA contents are undertaken. DNA Histograms of lymphoid cells, Immunoblasts, and epitheloid cells are evaluated for their euploid or aneuploid DNA contents. The aneuploid DNA stem line pattern found in the case under discussion testifies to the malignant nature of Lennert's Lyphoma.
1980: Pathology, Research and Practice
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