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cirrhosis biliar

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https://www.readbyqxmd.com/read/21850051/aav-vectors-transduce-hepatocytes-in-vivo-as-efficiently-in-cirrhotic-as-in-healthy-rat-livers
#1
L Sobrevals, M Enguita, C Rodriguez, J Gonzalez-Rojas, P Alzaguren, N Razquin, J Prieto, P Fortes
In liver cirrhosis, abnormal liver architecture impairs efficient transduction of hepatocytes with large viral vectors such as adenoviruses. Here we evaluated the ability of adeno-associated virus (AAV) vectors, small viral vectors, to transduce normal and cirrhotic rat livers. Using AAV serotype-1 (AAV1) encoding luciferase (AAV1Luc) we analyzed luciferase expression with a CCD camera. AAV1Luc was injected through the hepatic artery (intra-arterial (IA)), the portal vein (intra-portal (IP)), directly into the liver (intra-hepatic (IH)) or infused into the biliary tree (intra-biliar)...
April 2012: Gene Therapy
https://www.readbyqxmd.com/read/18785433/-liver-cirrhosis-caused-by-liver-echinococcosis
#2
G Stoianov, N Iarŭmov, N Damianov, Iu Ilieva
Systematic histological and ultra structural studies over operated patients and in experiment on white infantile mouse have revealed very serious liver alterations, when affected by echinococcosis. Alterations advance with disease progress and lead to cytological alterations in the organ in significant percent of the patients. Echinococcosis is accepted as etiological factor for cirrhosis. Echinococcosis should be included in the existing etiological classification: alcoholic, posthepatical, metabolic, biliar and cardiac...
2006: Khirurgiia
https://www.readbyqxmd.com/read/16829063/renal-dysfunction-as-a-consequence-of-acute-liver-damage-by-bile-duct-ligation-in-cirrhotic-rats
#3
Sandra Rivera-Huizar, Ana Rosa Rincón-Sánchez, Amador Covarrubias-Pinedo, María Cristina Islas-Carbajal, Genaro Gabriel-Ortíz, José Pedraza-Chaverrí, Adriana Alvarez-Rodríguez, Eduardo Meza-García, Juan Armendáriz-Borunda
UNLABELLED: Renal failure is a common complication in patients with alcohol-induced cirrhosis who undergo a superimposed severe alcoholic hepatitis. AIM: Our aim was to evaluate renal dysfunction established as a consequence of acute liver damage (ALD) induced by bile duct ligation (BDL) in cirrhotic rats. Hepatic and renal functional assays were performed. RESULTS: Hyperbilirubinemia and increased alanine aminotransferase and aspartate aminotransferase (p<0...
November 2006: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/15614298/-autoimmune-hepatitis-clinical-forms-and-related-factors-to-their-response-to-treatment
#4
Milagros Dávalos, Rossana Román, Carla Bustios, Eduardo Zumaeta, Alejandro Yabar
Chronic liver disease is a clinical entity of different origins. It is most frequently caused by viral infection and alcohol consumption. The entities of immunological origin are listed in third place including autoimmune hepatitis, primary biliar cirrhosis, primary sclerosing cholangitis, as well as superposition syndromes. In Peru report of cases relating to autoimmune hepatitis are very few and its frequency is unknown. In 2002, autoimmune etiology represented 13% of all the cases admitted in the Hepathology Unit of Edgardo Rebagliati Martins National Hospital ("HNERM") for chronic hepatic disease...
October 2004: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/12793191/-strategies-for-endoscopic-and-surgical-treatment-of-biliary-tract-calculi
#5
Dragos Stojanović, Mirjana Stojanović, Predrag Milojević, Zorica Caparević, Dorde Lalosević, Dragan Radovanović
INTRODUCTION: Common bile duct calculi represent a pathologic entity involving obstructive icterus, cholangitis, hepatic cirrhosis or pancreatitits. Common bile duct calculi mostly have a secondary origin (from gallbladder) in 95% of cases, while primary choledocholithiasis is rare. CLASSIFICATION: From surgical aspect, common bile duct calculi can be: 1. Asymptomatic, without manifested symptoms or signs, 2. Mobile, with intermittent biliar obstruction and disobstruction, 3...
January 2003: Medicinski Pregled
https://www.readbyqxmd.com/read/12025455/-secondary-biliary-cirrhosis-in-a-patient-with-histiocytosis-x
#6
Zita Romão, J Pontes, P Andrade, M C Leitão, A Donato, Diniz Freitas
Histiocitose X or Histiocytosis of the Langerhans cells represents a complex spectrum of clinical alterations, resulting from infiltration by anomalous histiocytes of various organs, including the skin, bones, lungs, lymphatic ganglia and liver. Liver disease is rare and the mechanism by which lesions appear is unknown. Cholestasis results from phenomena of sclerosant colangitis, which affects the intrahepatic ducts, or from proliferation of histiocytic cells in the periportal areas. Some patients develop biliar cyrrhosis...
January 2002: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/3255280/-treatment-of-cicatricial-stenosis-of-the-proximal-common-hepatic-duct-study-of-11-cases
#7
M B Speranzini, W Mittelstaedt, C Deutsch, J C Cunha, J Waisberg
Eleven patients with cicatricial stenosis in the junction area of hepatic ducts were evaluated. In all patients the injury occurred during cholescystectomy and no operative cholangiography was performed. In 3 patients the injury was recognized during the initial cholecistectomy. Ten patients had been operated on at least one time to correct the injury in other Services. Four cases had duct or peritoneal drainage. There was an attempt of reanastomosis in two cases. Five patients had a bilio-digestive anastomosis performed in variable occasions...
July 1988: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/2267049/-hepatolenticular-degeneration
#8
D Zudenigo, M Relja
Hepatolenticular degeneration (Wilson's disease) is a hereditary disease in which metabolic disorder of copper leads to its accumulation in the liver, brain, cornea and kidneys with consequent pathologic changes in those organs. Hereditary mechanism of the disease is autosomal recessive with prevalence of 30-100 per 1,000,000 inhabitants. Etiology of this disease is not yet explained. There are two hypotheses. The first one is that it is the disorder of ceruloplasmine metabolism caused by insufficient synthesis of normal ceruloplasmine, or synthesis of functionally abnormal ceruloplasmine...
1990: Neurologija
https://www.readbyqxmd.com/read/715342/-reynold-s-syndrome-a-case-report-author-s-transl
#9
J Alcocer, R Herrera, C Lavalle, J Gudiño, A Fraga
One case of the association of primary biliar cirrhosis and systemic sclerosis progressive (SSP) is described (Reynold's syndrome). This association has been reported in 21 patients. In our case the signs of liver disease precede two years the appearence of SSP. A review of the patients with Reynold's syndrome reported is done and compared with the present case. Diagnostic approach and management of this association is also discussed.
January 1978: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/608851/-surgical-problems-of-the-primary-sclerosing-cholangitis-author-s-transl
#10
Y Salembier, A Dupont, M Bleuez, J Paris
The characteristics of the primary sclerosing cholangitis are a diffuse inflammation with fibrous thickening and narrowing of the biliar ducts. Two observations replying to strict characteristics are related. From attacks of angiocholitis, the disease generally progresses till a parmanent icterus and death occurs in a state of biliar cirrhosis. In the liver, the micro pathology consists in fibrous rings constricting the segmentary interlobular ducts. The diagnostic is mainly difficult and the prognostic is fatal in average time of 4 years of evolution althought we used corticoids that were administrated by local method as well as in the classical general way...
1977: Journal de Chirurgie
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