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https://www.readbyqxmd.com/read/28449529/do-hospitals-need-oncological-critical-care-units
#1
EDITORIAL
Abby Koch, William Checkley
Since the inception of critical care as a formal discipline in the late 1950s, we have seen rapid specialization to many types of intensive care units (ICUs) to accommodate evolving life support technologies and novel therapies in various disciplines of medicine. Indeed, the field has expanded such that specialized ICUs currently exist to address critical care problems in medicine, cardiology, neurology and neurosurgery, trauma, burns, organ transplant and cardiothoracic surgeries. Specialization does not only need new infrastructure, but also training and staffing of health care providers, ancillary staff, and development and implementation of processes of care...
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28441509/patient-safety-and-quality-improvement-in-otolaryngology-education-a-systematic-review
#2
John D Gettelfinger, P Barrett Paulk, Cecelia E Schmalbach
Objective The breadth and depth of patient safety/quality improvement (PS/QI) research dedicated to otolaryngology-head and neck surgery (OHNS) education remains unknown. This systematic review aims to define this scope and to identify knowledge gaps as well as potential areas of future study to improved PS/QI education and training in OHNS. Data Sources A computerized Ovid/Medline database search was conducted (January 1, 1965, to May 15, 2015). Similar computerized searches were conducted using Cochrane Database, PubMed, and Google Scholar...
April 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28430703/evidence-based-recommendations-for-pediatric-orthopaedic-practice
#3
Kishore Mulpuri, Emily K Schaeffer, H Kerr Graham, Mininder S Kocher, James Sanders, Ira Zaltz
BACKGROUND: Evidence-based medicine has become the cornerstone to guide clinical practice decision-making. Evidence-based medicine integrates the strongest available evidence with clinical expertise to make decisions about clinical care. The quality of the evidence depends upon the soundness of the study methodology to allow for meaningful interpretation of the clinical results. The purpose of this review is to analyze the methodological design and clinical findings of published pediatric orthopaedic studies to determine their ability to change or influence clinical practice...
April 20, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28424084/durable-complete-remission-with-aromatase-inhibitor-therapy-in-a-patient-with-metastatic-uterine-carcinosarcoma-with-poor-performance-status-and-coagulation-disorders-a-case-report
#4
P Martin-Romano, M Jurado, M A Idoate, L Arbea, J L Hernandez-Lizoain, D Cano, J A Paramo, S Martin-Algarra
BACKGROUND: Chemotherapy is considered the most appropriate treatment for metastatic uterine sarcoma, despite its limited efficacy. No other treatment has been conclusively proved to be a real alternative, but some reports suggest that anti-hormonal therapy could be active in a small subset of patients. We report the case of a patient with metastatic uterine carcinosarcoma with positive hormonal receptors and a complete pathological response. CASE PRESENTATION: A 54-year-old white woman presented to our emergency room with hypovolemic shock and serious vaginal bleeding...
April 19, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28417852/nuclear-medicine-in-pediatric-nephro-urology-an-overview
#5
REVIEW
Iosif Mendichovszky, Bernardita Troncoso Solar, Naima Smeulders, Marina Easty, Lorenzo Biassoni
In the context of ante-natally diagnosed hydronephrosis, the vast majority of children with a dilated renal pelvis do not need any surgical treatment, as the dilatation resolves spontaneously with time. Slow drainage demonstrated at Tc-99m-mercaptoacetyltriglycine (MAG3) renography does not necessarily mean obstruction. Obstruction is defined as resistance to urinary outflow with urinary stasis at the level of the pelvic-ureteric junction (PUJ) which, if left untreated, will damage the kidney. Unfortunately this definition is retrospective and not clinically helpful...
May 2017: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/28413859/meniscus-articular-cartilage-and-nucleus-pulposus-a-comparative-review-of-cartilage-like-tissues-in-anatomy-development-and-function
#6
REVIEW
Song Chen, Peiliang Fu, Haishan Wu, Ming Pei
The degradation of cartilage in the human body is impacted by aging, disease, genetic predisposition and continued insults resulting from daily activity. The burden of cartilage defects (osteoarthritis, rheumatoid arthritis, intervertebral disc damage, knee replacement surgeries, etc.) is daunting in light of substantial economic and social stresses. This review strives to broaden the scope of regenerative medicine and tissue engineering approaches used for cartilage repair by comparing and contrasting the anatomical and functional nature of the meniscus, articular cartilage (AC) and nucleus pulposus (NP)...
April 17, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28393540/microfracture-state-of-the-art-in-cartilage-surgery
#7
Florian Frehner, Jan P Benthien
Objective This study is a literature review from 2010 to 2014 concerning the quality of evidence in clinical trials about microfracture in attempt to repair articular cartilage. We have decided to focus on microfracturing, since this seems to be the best documented technique. Interest in evaluation of publication quality has risen in orthopaedic sports medicine recently. Therefore, we think it is necessary to evaluate recent clinical trials being rated for their evidence-based medicine (EBM) quality. We also compared the mean impact factor of the journals publishing the different studies as an indicator of the study's citation and evaluated for a change over the studied time frame...
April 1, 2017: Cartilage
https://www.readbyqxmd.com/read/28393339/-the-status-change-and-health-issues-of-inpatients-sixth-vital-sign-in-a-medical-center
#8
Li-Ying Lin, Ya-Hui Huang, Chung-Lung Hung, Ya-Mei Chen, Ching-Ju Kuo, Yan-Chiou Ku
BACKGROUND: Hospitalized patients generally have elevated levels of emotional distress. Gaining a better under-standing of the problem of emotional distress among hospitalized patients is conducive to providing appropriate emotional care and promoting their recovery. PURPOSE: To analyze the scores for the "sixth vital sign" (i.e., emotional distress), diversification, and the health-related problems of hospitalized patients at a medical center in Taiwan. The results may offer an important reference for providing effective emotional care to hospitalized patients...
April 2017: Hu Li za Zhi the Journal of Nursing
https://www.readbyqxmd.com/read/28382802/major-clinical-research-advances-in-gynecologic-cancer-in-2016-10-year-special-edition
#9
REVIEW
Dong Hoon Suh, Miseon Kim, Kidong Kim, Hak Jae Kim, Kyung Hun Lee, Jae Weon Kim
In 2016, 13 topics were selected as major research advances in gynecologic oncology. For ovarian cancer, study results supporting previous ones regarding surgical preventive strategies were reported. There were several targeted agents that showed comparable responses in phase III trials, including niraparib, cediranib, and nintedanib. On the contrary to our expectations, dose-dense weekly chemotherapy regimen failed to prove superior survival outcomes compared with conventional triweekly regimen. Single-agent non-platinum treatment to prolong platinum-free-interval in patients with recurrent, partially platinum-sensitive ovarian cancer did not improve and even worsened overall survival (OS)...
May 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/28376904/academic-research-productivity-of-post-graduate-students-at-makerere-university-college-of-health-sciences-uganda-from-1996-to-2010-a-retrospective-review
#10
E A Obuku, J N Lavis, A Kinengyere, D K Mafigiri, F Sengooba, C Karamagi, N K Sewankambo
BACKGROUND: Research is a core business of universities globally, and is crucial in the scientific process as a precursor for knowledge uptake and use. We aimed to assess the academic productivity of post-graduate students in a university located in a low-income country. METHODS: This is an observational retrospective documentary analysis using hand searching archives, Google Scholar and PubMed electronic databases. The setting is Makerere University College of Health Sciences, Uganda...
April 4, 2017: Health Research Policy and Systems
https://www.readbyqxmd.com/read/28373987/hydrocephalus-after-subarachnoid-hemorrhage-pathophysiology-diagnosis-and-treatment
#11
REVIEW
Sheng Chen, Jinqi Luo, Cesar Reis, Anatol Manaenko, Jianmin Zhang
Hydrocephalus (HCP) is a common complication in patients with subarachnoid hemorrhage. In this review, we summarize the advanced research on HCP and discuss the understanding of the molecular originators of HCP and the development of diagnoses and remedies of HCP after SAH. It has been reported that inflammation, apoptosis, autophagy, and oxidative stress are the important causes of HCP, and well-known molecules including transforming growth factor, matrix metalloproteinases, and iron terminally lead to fibrosis and blockage of HCP...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28368852/biomedical-applications-of-nanodiamond-review
#12
Kostiantyn Turcheniuk, Vadym Mochalin
The interest to applications of nanodiamond in biology and medicine is on the rise over the recent years. This is due to the unique combination of properties that nanodiamond provides. Small size (~ 5 nm), low cost, scalable production, negligible toxicity, chemical inertness of diamond core and rich chemistry of nanodiamond surface, as well as bright and robust fluorescence resistant to photobleaching are the distinct parameters that render nanodiamond superior to any other nanomaterial when it comes to biomedical applications...
April 3, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28368668/immunotherapy-for-head-and-neck-cancer-the-future-of-treatment
#13
Xiujie Xie, Wendi O'Neill, Quintin Pan
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide with >500,000 cases diagnosed each year. HNSCC patients often present to the clinic with advanced disease and are managed with a multi-disciplinary approach consisting of surgery, chemotherapy, and/or radiation. Morbidity and quality of life issues are major challenges in this patient population due to the debilitating effects of standard of care treatment paradigms. There is a critical need for new therapeutic approaches to manage HNSCC with better anti-tumor activities and toxicity profiles...
April 11, 2017: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/28368130/a-novel-technique-in-root-coverage-procedures-the-fibrin-assisted-soft-tissue-promotion-concept
#14
Alexandre-Amir Aalam, Alina Krivitky Aalam, Joseph Choukroun
The goal of periodontal plastic surgery is to correct the soft-tissue deformities associated with the loss of attached and keratinized tissue. A variety of flap manipulations related to the use of subepithelial connective tissue grafts are described with great success in the literature but are linked with morbidity and harvesting-quality issues, inclining clinicians and researchers to find alternatives to such techniques. Advanced platelet-rich fibrin, which is widely used in medicine and oral therapy, represents a newer generation of blood-derived growth factors...
April 2017: Compendium of Continuing Education in Dentistry
https://www.readbyqxmd.com/read/28365240/using-electronic-health-records-to-build-an-ophthalmological-data-warehouse-and-visualize-patients-data
#15
Karsten U Kortüm, Michael Müller, Christoph Kern, Alexander Babenko, Wolfgang J Mayer, Anselm Kampik, Thomas C Kreutzer, Siegfried Priglinger, Christoph Hirneiss
PURPOSE: To develop a near real-time data warehouse (DW) in an academic ophthalmological center to gain scientific use of increasing digital data from electronic medical records (EMR) and diagnostic devices. Design; Database development METHODS: Specific macular clinic user interfaces within the institutional hospital information system were created. Orders for imaging modalities were sent by an EMR -linked picture-archiving and communications system to the respective devices. All data of 325,767 patients since 2002 were gathered in a DW running on a SQL database...
March 29, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28362214/a-systematic-multidisciplinary-initiative-for-reducing-the-risk-of-complications-in-adult-scoliosis-surgery
#16
Rajiv Sethi, Quinlan D Buchlak, Vijay Yanamadala, Melissa L Anderson, Eric A Baldwin, Robert S Mecklenburg, Jean-Christophe Leveque, Alicia M Edwards, Mary Shea, Lisa Ross, Karen J Wernli
OBJECTIVE Systematic multidisciplinary approaches to improving quality and safety in complex surgical care have shown promise. Complication rates from complex spine surgery range from 10% to 90% for all surgeries, and the overall mortality rate is 1%-4%. These rates suggest the need for improved perioperative complex spine surgery processes designed to minimize risk and improve quality. METHODS The Group Health Research Institute and Virginia Mason Medical Center implemented a systematic multidisciplinary protocol, the Seattle Spine Team Protocol, in 2010...
March 31, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28361059/in-vitro-prediction-of-breast-cancer-therapy-toxicity
#17
Michael J McKay, Jezzie Maneerat, Timothy M McKay, Jeremy N McKay, Reza Masoud-Rahbari
BACKGROUND: Understanding the basis of clinical radiosensitivity is a key goal of radiation research. In this study, we used the limiting dilution assay (LDA) to analyze in vitro radiosensitivity of cell lines from individuals with breast and other cancers, who had been treated with ionizing radiation, and who either had a non-radiosensitive (RS) radiation response or who were clinically RS. METHODS: Lymphoblastoid cell lines (LCLs) were created from 29 cancer patients including 19 RS patients, 10 controls who had not developed severe normal tissue reactions, and 1 ataxia telangiectasia RS control cell line...
March 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28355085/validation-of-a-dry-model-for-assessing-the-performance-of-arthroscopic-hip-labral-repair
#18
Lisa Phillips, Jeffrey J H Cheung, Daniel B Whelan, Michael Lucas Murnaghan, Jas Chahal, John Theodoropoulos, Darrell Ogilvie-Harris, Ian Macniven, Tim Dwyer
BACKGROUND: Arthroscopic hip labral repair is a technically challenging and demanding surgical technique with a steep learning curve. Arthroscopic simulation allows trainees to develop these skills in a safe environment. PURPOSE: The purpose of this study was to evaluate the use of a combination of assessment ratings for the performance of arthroscopic hip labral repair on a dry model. STUDY DESIGN: Cross-sectional study; Level of evidence, 3...
March 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28345371/ewma-document-negative-pressure-wound-therapy
#19
Jan Apelqvist, Christian Willy, Ann-Mari Fagerdahl, Marco Fraccalvieri, Malin Malmsjö, Alberto Piaggesi, Astrid Probst, Peter Vowden
1. Introduction Since its introduction in clinical practice in the early 1990's negative pressure wounds therapy (NPWT) has become widely used in the management of complex wounds in both inpatient and outpatient care.(1) NPWT has been described as a effective treatment for wounds of many different aetiologies(2,3) and suggested as a gold standard for treatment of wounds such as open abdominal wounds,(4-6) dehisced sternal wounds following cardiac surgery(7,8) and as a valuable agent in complex non-healing wounds...
March 1, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28343637/investigation-of-preoperative-fasting-times-in-children
#20
Eda Dolgun, Meryem Yavuz, Birsen Eroğlu, Ayşe Islamoğlu
PURPOSE: The aim of this study was to investigate preoperative fasting times of children. DESIGN: A prospective and descriptive design was used. METHODS: The study was carried out in the pediatric surgery departments of a University Faculty of Medicine Hospital, between January 1 and May 31, 2012. The sample included 332 pediatric patients having surgery with general anesthesia and their family. Data were collected via patient and family interview using a 28-item questionnaire developed by the researchers...
April 2017: Journal of Perianesthesia Nursing: Official Journal of the American Society of PeriAnesthesia Nurses
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