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https://www.readbyqxmd.com/read/29782345/precision-surgery-for-obesity
#1
Zhiyong Dong, Sheikh Mohammed Shariful Islam, Enan Simms-Walker, Cunchuan Wang
Precision medicine is targeted towards improving the effectiveness of treatment, reducing the side effects of drugs and reducing medical costs. The application of precision surgery for obesity is a new concept that involves 2 stages: the first stage is to attain a precise obesity surgery, and the second stage is to achieve individualized obese gene therapy. In this article, we discuss the value of precision surgery for obesity, its stages and its future application to improve obesity surgery. Due to recent advancements in medical technologies, genetics, surgical and clinical research; precision surgery for obesity will lead the future of obesity surgery...
May 16, 2018: American Journal of Therapeutics
https://www.readbyqxmd.com/read/29770299/regenerative-medicine-therapy-for-single-ventricle-congenital-heart-disease
#2
REVIEW
Chetan Ambastha, Gregory J Bittle, David Morales, Nathaniel Parchment, Progyaparamita Saha, Rachana Mishra, Sudhish Sharma, Alexander Vasilenko, Muthukumar Gunasekaran, Manal T Al-Suqi, Deqiang Li, Peixin Yang, Sunjay Kaushal
One of the most complex forms of congenital heart disease (CHD) involving single ventricle physiology is hypoplastic left heart syndrome (HLHS), characterized by underdevelopment of the left ventricle (LV), mitral and aortic valves, and narrowing of the ascending aorta. The underdeveloped LV is incapable of providing long-term systemic flow, and if left untreated, the condition is fatal. Current treatment for this condition consists of three consecutive staged palliative operations: the first is conducted within the first few weeks of birth, the second between 4 to 6 months, and the third and final surgery within the first 4 years...
April 2018: Translational Pediatrics
https://www.readbyqxmd.com/read/29770294/three-dimensional-modelling-and-three-dimensional-printing-in-pediatric-and-congenital-cardiac-surgery
#3
REVIEW
Laszlo Kiraly
Three-dimensional (3D) modelling and printing methods greatly support advances in individualized medicine and surgery. In pediatric and congenital cardiac surgery, personalized imaging and 3D modelling presents with a range of advantages, e.g., better understanding of complex anatomy, interactivity and hands-on approach, possibility for preoperative surgical planning and virtual surgery, ability to assess expected results, and improved communication within the multidisciplinary team and with patients. 3D virtual and printed models often add important new anatomical findings and prompt alternative operative scenarios...
April 2018: Translational Pediatrics
https://www.readbyqxmd.com/read/29764209/next-gen-therapeutics-for-skin-cancer-nutraceuticals
#4
Annapoorna Sreedhar, Jun Li, Yunfeng Zhao
Growing modernization and lifestyle changes with limited physical activity have impacted diet and health, leading to an increased cancer mortality rate worldwide. As a result, there is a greater need than before to develop safe and novel anticancer drugs. Current treatment options such as chemotherapy, radiotherapy and surgery, induce unintended side effects, compromising patient's quality of life, and physical well-being. Therefore, there has been an increased global interest in the use of dietary supplements and traditional herbal medicines for treatment of cancer...
May 15, 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29759029/burnout-in-otolaryngology-head-and-neck-surgery-a-single-academic-center-experience
#5
Katie Geelan-Hansen, Samantha Anne, Michael S Benninger
Burnout in modern medicine is becoming more recognized and researched. The objective in this study is to evaluate burnout in a tertiary care academic institution and compare results among faculty, trainees, and advanced practice practitioners (APPs) in a cross-sectional survey using the Maslach Burnout Inventory. Fifty-two surveys were distributed; 44 participants completed the survey (85%): 25 staff physicians (57%), 14 resident physicians (32%), and 5 nurse practitioners (11%). Staff physicians had low emotional exhaustion, moderate depersonalization, and low result for reduced personal accomplishments; trainees reported low emotional exhaustion, high depersonalization, and moderate reduced personal accomplishment; and nurse practitioners reported moderate on all 3 dimensions...
May 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29755358/therapeutic-angiogenesis-of-chinese-herbal-medicines-in-ischemic-heart-disease-a-review
#6
REVIEW
Dongqing Guo, Colin E Murdoch, Tianhua Liu, Jia Qu, Shihong Jiao, Yong Wang, Wei Wang, Xing Chen
Ischemic heart disease (IHD) is one of the primary causes of death around the world. Therapeutic angiogenesis is a promising innovative approach for treating IHD, improving cardiac function by promoting blood perfusion to the ischemic myocardium. This treatment is especially important for targeting patients that are unable to undergo angioplasty or bypass surgery. Chinese herbal medicines have been used for more than 2,500 years and they play an important role alongside contemporary medicines in China. Growing evidence in animal models show Chinese herbal medicines can provide therapeutic effect on IHD by targeting angiogenesis...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29750318/return-to-play-after-patellar-stabilization
#7
REVIEW
Seth L Sherman, Daniel P Deasis, Andrew J Garrone, Elliott E Voss, Harvey A Oliver
PURPOSE OF REVIEW: The purpose of this review is to evaluate the existing literature regarding return to play (RTP) and return to prior performance (RPP) following patellar stabilization surgery. It will also discuss suggested guidelines regarding RTP, and finally, to encourage future patellofemoral instability research to report and publish results of RTP rates using standardized RTP guidelines. RECENT FINDINGS: There is a lack of validation and universal adoption of standardized RTP guidelines...
May 10, 2018: Current Reviews in Musculoskeletal Medicine
https://www.readbyqxmd.com/read/29735382/evidence-based-nonpharmacologic-strategies-for-comprehensive-pain-care-the-consortium-pain-task-force-white-paper
#8
Heather Tick, Arya Nielsen, Kenneth R Pelletier, Robert Bonakdar, Samantha Simmons, Ronald Glick, Emily Ratner, Russell L Lemmon, Peter Wayne, Veronica Zador
Consortium Pain Taskforce White Paper Summary Evidence-based Nonpharmacologic Strategies for Comprehensive Pain Care Supplementary information can be found in the online version at https://doi.org/10.1016/j.explore.2018.02.001. Medical pain management is in crisis; from the pervasiveness of pain to inadequate pain treatment, from the escalation of prescription opioids to an epidemic in addiction, diversion and overdose deaths. The rising costs of pain care and managing adverse effects of that care have prompted action from state and federal agencies including the DOD, VHA, NIH, FDA and CDC...
March 1, 2018: Explore: the Journal of Science and Healing
https://www.readbyqxmd.com/read/29734008/biochemistry-and-biomedicine-of-quantum-dots-from-biodetection-to-bioimaging-drug-discovery-diagnosis-and-therapy
#9
REVIEW
Jun Yao, Pingfan Li, Lin Li, Mei Yang
According to recent research, nanotechnology based on quantum dots (QDs) has been widely applied in the field of bioimaging, drug delivery, and drug analysis. Therefore, it has become one of the major forces driving basic and applied research. The application of nanotechnology in bioimaging has been of concern. Through in vitro labeling, it was found that luminescent QDs possess many properties such as narrow emission, broad UV excitation, bright fluorescence, and high photostability. The QDs also show great potential in whole-body imaging...
May 4, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29733571/aggregation-induced-emission-aie-dots-emerging-theranostic-nanolights
#10
Guangxue Feng, Bin Liu
Theranostic nanolights refer to luminescent nanoparticles possessing both imaging and therapeutic functions. Their shape, size, surface functions, and optical properties can be precisely manipulated through integrated efforts of chemistry, materials, and nanotechnology for customized applications. When localized photons are used to activate both imaging and therapeutic functions such as photodynamic or photothermal therapy, these theranostic nanolights increase treatment efficacy with minimized damage to surrounding healthy tissues, which represents a promising noninvasive nanomedicine as compared to conventional theranostic approaches...
May 7, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29732166/secondary-use-of-electronic-medical-records-for-clinical-research-challenges-and-opportunities
#11
Wen-Wai Yim, Amanda J Wheeler, Catherine Curtin, Todd H Wagner, Tina Hernandez-Boussard
With increasingly ubiquitous electronic medical record (EMR) implementation accelerated by the adoption of the HITECH Act, there is much interest in the secondary use of collected data to improve outcomes and promote personalized medicine. A plethora of research has emerged using EMRs to investigate clinical research questions and assess variations in both treatments and outcomes. However, whether because of genuine complexities of modeling disease physiology or because of practical problems regarding data capture, data accuracy, and data completeness, the state of current EMR research is challenging and gives rise to concerns regarding study accuracy and reproducibility...
March 2018: Convergent Science Physical Oncology
https://www.readbyqxmd.com/read/29731951/advanced-computational-methods-in-bio-mechanics
#12
REVIEW
Waleed M S Al Qahtani, Mohamed I El-Anwar
A novel partnership between surgeons and machines, made possible by advances in computing and engineering technology, could overcome many of the limitations of traditional surgery. By extending surgeons' ability to plan and carry out surgical interventions more accurately and with fewer traumas, computer-integrated surgery (CIS) systems could help to improve clinical outcomes and the efficiency of healthcare delivery. CIS systems could have a similar impact on surgery to that long since realised in computer-integrated manufacturing...
April 15, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29730180/social-media-in-surgical-training-opportunities-and-risks
#13
Sander Ovaere, David D E Zimmerman, Richard R Brady
BACKGROUND: Surgeon engagement with social media is growing rapidly. Innovative applications in diverse fields of health care are increasingly available. OBJECTIVE: The aim of this review is to explore the current and future applications of social media in surgical training. In addition, risks and barriers of social media engagement are analyzed, and recommendations for professional social media use amongst trainers and trainees are suggested. METHODS: The published, peer-reviewed literature on social media in medicine, surgery and surgical training was reviewed...
May 2, 2018: Journal of Surgical Education
https://www.readbyqxmd.com/read/29729004/italian-consensus-on-diagnosis-and-treatment-of-differentiated-thyroid-cancer-joint-statements-of-six-italian-societies
#14
F Pacini, F Basolo, R Bellantone, G Boni, M A Cannizzaro, M De Palma, C Durante, R Elisei, G Fadda, A Frasoldati, L Fugazzola, R Guglielmi, C P Lombardi, P Miccoli, E Papini, G Pellegriti, L Pezzullo, A Pontecorvi, M Salvatori, E Seregni, P Vitti
BACKGROUND: Thyroid nodules are a common clinical problem, and differentiated thyroid cancer is becoming increasingly prevalent. METHODS: Six scientific Italian societies entitled to cure thyroid cancer patients (the Italian Thyroid Association, the Medical Endocrinology Association, the Italian Society of Endocrinology, the Italian Association of Nuclear Medicine and Molecular Imaging, the Italian Society of Unified Endocrine Surgery and the Italian Society of Anatomic Pathology and Diagnostic Cytology) felt the need to develop a consensus report based on significant scientific advances occurred in the field...
May 4, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29727412/evidence-based-medicine-in-pediatric-orthopaedics-evidence-based-practice-committee-summary-of-levels-of-evidence-clinical-practice-guidelines-appropriate-use-criteria-and-best-practice-guidelines
#15
Jigar S Gandhi, Kevin G Shea, Paul D Sponseller, Brian K Brighton, Theodore J Ganley
The concept of evidence-based medicine has evolved over the past 2 decades, and has become a cornerstone to clinical decision-making in virtually every aspect of medicine. With a commitment to providing its members with high-quality evidence-based guidelines, the American Academy of Orthopaedic Surgeons has instituted concerted efforts since 2006 to develop clinical practice guidelines (CPGs) and appropriate use criteria (AUCs) for certain orthopaedic conditions. Many of these CPGs and AUCs detail the management of pediatric orthopaedic conditions...
April 30, 2018: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29727014/a-novel-rabbit-model-of-moderate-knee-contracture-induced-by-direct-capsular-damage
#16
David Hazlewood, Yi Feng, Qinghua Lu, Xinmai Yang, Jinxi Wang
The treatment of joint contracture continues to represent a challenging problem in orthopedic surgery and rehabilitation medicine. Existing animal models of knee contracture for evaluating new treatments are mostly created by extensive joint tissue damage with Kirschner-wire immobilization which requires a second surgery to remove Kirschner-wires. This study aimed to develop a less invasive rabbit model of moderate knee contracture through a single surgery. Skeletally mature New Zealand White rabbits had their right knee operated to create surgical damage to the posterior capsule under direct visualization...
May 4, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29723676/towards-optimal-intraoperative-conditions-in-esophageal-surgery-a-review-of-literature-for-the-prevention-of-esophageal-anastomotic-leakage
#17
REVIEW
Boukje Titia Bootsma, Daitlin Esmee Huisman, Victor Dirk Plat, Linda Jeanne Schoonmade, Jurre Stens, Guy Hubens, Donald Leonard van der Peet, Freek Daams
BACKGROUND: Esophageal anastomotic leakage (EAL) is a severe complication following gastric and esophageal surgery for cancer. Several non-modifiable, patient or surgery related risk factors for EAL have been identified, however, the contribution of modifiable intraoperative parameters remains undetermined. This review provides an overview of current literature on potentially modifiable intraoperative risk factors for EAL. MATERIALS AND METHODS: The PubMed, EMBASE and Cochrane databases were searched by two researchers independently...
April 30, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29722765/making-them-commit-strategies-to-influence-phenotypic-differentiation-in-mesenchymal-stem-cells
#18
Alessio Giai Via, Mary B McCarthy, Laura de Girolamo, Enrico Ragni, Francesco Oliva, Nicola Maffulli
Tendon injuries, bone defects, and cartilage defects are complex clinical conditions leading to pain and dysfunctions. Tendon, bone, and cartilage are highly specialized and organized tissues, and the self-healing may be limited by their histologic features, or impaired by the local conditions. Furthermore, the resultant tissue often shows inferior properties compared with native tissue, leading to high rates of reruptures and revision surgeries. A growing field of research has explored tendon, bone, and cartilage regeneration using mesenchymal stem cells (MSCs), because of their multipotency, and because they are relatively easy to harvest...
June 2018: Sports Medicine and Arthroscopy Review
https://www.readbyqxmd.com/read/29717338/trends-in-rhinoplasty-research-a-20-year-bibliometric-analysis
#19
Shadi Lalezari, David A Daar, Prakash J Mathew, Donald S Mowlds, Keyianoosh Z Paydar, Garrett A Wirth
BACKGROUND: Rhinoplasty is a popular aesthetic and reconstructive surgical procedure. It is one of the top five surgical cosmetic procedures performed worldwide. OBJECTIVES: To evaluate global trends in rhinoplasty research spanning 20 years between 1994 and 2013. METHODS: The top 15 plastic surgery and otolaryngology journals containing rhinoplasty research were determined using impact factors (IF). A database of rhinoplasty articles from 1994 to 2013 was created to include the following classifications: IF, authors' geographic location, study design, level of evidence (LOE), and pertinence to aesthetic or reconstructive rhinoplasty...
May 1, 2018: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29715759/cardioprotective-effect-of-amaranthus-tricolor-extract-in-isoprenaline-induced-myocardial-damage-in-ovariectomized-rats
#20
Kamrun Nahar, Fariha Kabir, Priota Islam, Md Mizanur Rahman, Md Abdullah Al Mamun, Md Faruk, Nusrat Subhan, G M Sayedur Rahman, Hasan Mahmud Reza, Md Ashraful Alam
Red spinach (Amaranthus tricolor) has been reported to possess many benefits and medicinal properties and used as a part of traditional medicine in Ayurveda and Siddha. The aim of the study was to investigate the effects of Amaranthus tricolor on isoproterenol-induced oxidative stress, fibrosis, and myocardial damage in ovariectomized rats. Ovariectomy surgery was conducted to remove both ovaries from the rats. After recovery, rats were administered with ISO subcutaneously (50 mg/kg) twice a week and were treated with ethanolic extracts of A...
April 27, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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