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https://www.readbyqxmd.com/read/27872049/contribution-of-kv1-5-channel-to-h2o2-induced-human-arteriolar-dilation-and-its-modulation-by-coronary-artery-disease
#1
Yoshinori Nishijima, Sheng Cao, Dawid S Chabowski, Ankush Korishettar, Alyce Ge, Xiaodong Zheng, Rodney Sparapani, David D Gutterman, David X Zhang
RATIONALE: Hydrogen peroxide (H2O2) regulates vascular tone in the human microcirculation under physiological and pathophysiological conditions. It dilates arterioles by activating BKCa channels in subjects with coronary artery disease (CAD), but its mechanisms of action in subjects without CAD (non-CAD) as compared to those with CAD remain unknown. OBJECTIVE: We hypothesize that H2O2-elicited dilation involves different K(+) channels in non-CAD versus CAD, resulting in an altered capacity for vasodilation during disease...
November 21, 2016: Circulation Research
https://www.readbyqxmd.com/read/27862767/dynamics-of-cerebral-blood-flow-in-patients-with-mild-non-ischaemic-heart-failure
#2
Christian D Erkelens, Haye H van der Wal, Bauke M de Jong, Jan-Willem Elting, Remco Renken, Marleen Gerritsen, Peter Jan van Laar, Vincent M van Deursen, Peter van der Meer, Dirk J van Veldhuisen, Adriaan A Voors, Gert-Jan Luijckx
AIMS: Heart failure (HF) is associated with tissue hypoperfusion and congestion leading to organ dysfunction. Although cerebral blood flow (CBF) is preserved over a wide range of perfusion pressures in healthy subjects, it is impaired in end-stage HF. We aimed to compare CBF, autoregulation, and cognitive function in patients with mild non-ischaemic HF with healthy controls. METHODS AND RESULTS: Fifteen patients with mild idiopathic dilated cardiomyopathy and 15 matched healthy controls were studied...
November 14, 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27822682/the-different-facets-of-dyslipidemia-and-hypertension-in-atherosclerosis
#3
REVIEW
Jessica Hurtubise, Krystie McLellan, Kevin Durr, Oluwadara Onasanya, Daniel Nwabuko, Joseph Fomusi Ndisang
Atherosclerosis is the narrowing of arteries due to the accumulation of macrophages overloaded with lipids resulting in foam cell formation, and these events occur preferentially at the branching points of arteries which are particularly susceptible to hyperlipidemic stress-induced inflammation and oxidative stress. The different stages of atherogenesis rely on oxidative stress, endothelial dysfunction, and inflammation, and hypertension or dyslipidemia can independently trigger these stages. Dyslipidemia and hypertension are pathological conditions that damage the endothelium, triggering cell proliferation, vascular remodeling, apoptosis, and increased cellular permeability with increased adhesion molecules that bind monocytes and T lymphocytes to create a vicious cocktail of pathophysiological factors...
December 2016: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/27793855/functional-vascular-contributions-to-cognitive-impairment-and-dementia-vcid-mechanisms-and-consequences-of-cerebral-microvascular-dysfunction-in-aging
#4
Peter Toth, Stefano Tarantini, Anna Csiszar, Zoltan I Ungvari
Increasing evidence from epidemiological, clinical and experimental studies indicate that age-related cerebromicrovascular dysfunction and microcirculatory damage play critical roles in the pathogenesis of many types of dementia in the elderly, including Alzheimer's disease. Understanding and targeting the age-related pathophysiological mechanisms that underlie vascular contributions to cognitive impairment and dementia (VCID) is expected to have a major role in preserving brain health in older individuals...
October 28, 2016: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/27754291/br-08-3-management-of-dyslipidemia-in-hypertension
#5
V V Muthusamy
Cardiovascular disease burden is increasing all over the world. The diagnosis of hypertension is considered when a person has persistently elevated BP (Systolic BP more than 140 mmHg and/or Diastolic BP more than 90 mmHg). Dyslipidemia denotes abnormal levels of lipids in the blood (Total Cholesterol >200 mg%, Low density lipoprotein (LDL) >100 mg%, Triglycerides (TGL) >150 mg% and High density lipoprotein (HDL) <40 mg in men and < 50 mg in women. Hypertension and Dyslipidemia constitute the important components of metabolic syndrome as per the definition of NCEP Guidelines-Adult Treatment Panel III (ATP III)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27747211/subfailure-overstretch-injury-leads-to-reversible-functional-impairment-and-purinergic-p2x7-receptor-activation-in-intact-vascular-tissue
#6
Weifeng Luo, Christy M Guth, Olukemi Jolayemi, Craig L Duvall, Colleen Marie Brophy, Joyce Cheung-Flynn
Vascular stretch injury is associated with blunt trauma, vascular surgical procedures, and harvest of human saphenous vein for use in vascular bypass grafting. A model of subfailure overstretch in rat abdominal aorta was developed to characterize surgical vascular stretch injury. Longitudinal stretch of rat aorta was characterized ex vivo. Stretch to the haptic endpoint, where the tissues would no longer lengthen, occurred at twice the resting length. The stress produced at this length was greater than physiologic mechanical forces but well below the level of mechanical disruption...
2016: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/27660577/false-positive-stress-echocardiograms-a-continuing-challenge
#7
REVIEW
Salima Qamruddin
BACKGROUND: Stress echocardiography is an integral test in the cardiac diagnostic laboratory and has high sensitivity and specificity. Despite the excellent specificity of stress echocardiography, we continue to see a subset of patients with false-positive tests (defined as <50% diameter stenosis on subsequent coronary angiography). These false-positive findings present a management challenge because it remains unclear if and how to treat these patients. METHODS: This article reviews relevant clinical studies and their outcomes...
2016: Ochsner Journal
https://www.readbyqxmd.com/read/27644002/controversies-over-the-use-of-gnrh-agonists-for-reduction-of-chemotherapy-induced-gonadotoxicity
#8
M F Garrido-Oyarzún, C Castelo-Branco
The increase in cancer incidence in younger people and the significant improvement in long and permanent remission have brought concern about their reproductive future and quality of life. Up to two-thirds of adult female patients undergoing chemotherapy for malignancies eventually develop premature ovarian failure. This condition is related to many complaints including vasomotor symptoms, osteoporosis, increased risk of cardiovascular diseases, sexual dysfunction, and infertility. Therefore, protection against iatrogenic infertility and loss of endocrine ovarian function caused by chemotherapy is currently of high priority...
September 17, 2016: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/27643289/br-08-3-management-of-dyslipidemia-in-hypertension
#9
V V Muthusamy
Cardiovascular disease burden is increasing all over the world. The diagnosis of hypertension is considered when a person has persistently elevated BP (Systolic BP more than 140 mmHg and/or Diastolic BP more than 90 mmHg). Dyslipidemia denotes abnormal levels of lipids in the blood (Total Cholesterol >200 mg%, Low density lipoprotein (LDL) >100 mg%, Triglycerides (TGL) >150 mg% and High density lipoprotein (HDL) <40 mg in men and < 50 mg in women. Hypertension and Dyslipidemia constitute the important components of metabolic syndrome as per the definition of NCEP Guidelines-Adult Treatment Panel III (ATP III)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27625162/proteinase-activated-receptor-2-counterbalances-the-vascular-effects-of-endothelin-1-in-fibrotic-tight-skin-mice
#10
Fiorentina Roviezzo, Vincenzo Brancaleone, Valentina Mattera Iacono, Antonio Bertolino, Giovanna De Cunto, Valentina Vellecco, Giuseppe Lungarella, Monica Lucattelli, Giuseppe Cirino
BACKGROUND AND PURPOSE: The majority of the severe vascular complications in fibrosis are a consequence of a deregulated activity of mediators controlling vasomotor tone. One of the most important of these mediators is endothelin-1 (ET-1). Here, we have investigated the role of proteinase-activated receptor 2 (PAR2) in the vascular dysfunction in a model of fibrosis, using tight-skin (Tsk) mice. EXPERIMENTAL APPROACH: Aortas were collected from Tsk, transgenic over-expressing PAR2 (TgPAR2), PAR2 deficient (PAR2(-/-) ) or the corresponding WT mice...
September 14, 2016: British Journal of Pharmacology
https://www.readbyqxmd.com/read/27613549/the-right-ventricle-interaction-with-the-pulmonary-circulation
#11
REVIEW
Michael R Pinsky
The primary role of the right ventricle (RV) is to deliver all the blood it receives per beat into the pulmonary circulation without causing right atrial pressure to rise. To the extent that it also does not impede left ventricular (LV) filling, cardiac output responsiveness to increased metabolic demand is optimized. Since cardiac output is a function of metabolic demand of the body, during stress and exercise states the flow to the RV can vary widely. Also, instantaneous venous return varies widely for a constant cardiac output as ventilatory efforts alter the dynamic pressure gradient for venous return...
September 10, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27571356/inflammation-and-vascular-effects-after-repeated-intratracheal-instillations-of-carbon-black-and-lipopolysaccharide
#12
Daniel Vest Christophersen, Nicklas Raun Jacobsen, Ditte Marie Jensen, Ali Kermanizadeh, Majid Sheykhzade, Steffen Loft, Ulla Vogel, Håkan Wallin, Peter Møller
Inflammation and oxidative stress are considered the main drivers of vasomotor dysfunction and progression of atherosclerosis after inhalation of particulate matter. In addition, new studies have shown that particle exposure can induce the level of bioactive mediators in serum, driving vascular- and systemic toxicity. We aimed to investigate if pulmonary inflammation would accelerate nanoparticle-induced atherosclerotic plaque progression in Apolipoprotein E knockout (ApoE-/-) mice. ApoE -/- mice were exposed to vehicle, 8...
2016: PloS One
https://www.readbyqxmd.com/read/27567631/h2s-prevents-cyclosporine-a-induced-vasomotor-alteration-in-rats
#13
Na-Na Ping, Yan-Ni Mi, Dong-Zheng Liu, Sai Zhang, Jing-Guo Chen, Yong-Xiao Cao
Cyclosporine A (CsA) induces hypertension after transplantation. Hydrogen sulfide (H2S) was found to have hypotensive/vasoprotective effects in the cardiovascular system. The present study aims to investigate the role of H2S on CsA-induced vascular function disorder in rats. Rats were subcutaneously injected with CsA 25 mg/kg for 21 days. Blood pressure was measured by the tail-cuff method. Vasomotion was determined using a sensitive myograph. Western blotting and immunohistochemistry were used to quantify the protein expression of endothelin type A (ETA) receptor and essential MAPK pathway molecules...
August 27, 2016: Cardiovascular Toxicology
https://www.readbyqxmd.com/read/27553189/cerebral-vasomotor-reactivity-in-neurodegenerative-diseases
#14
Łukasz Smoliński, Anna Członkowska
Small-caliber cerebral vessels change their diameters in response to alterations of key metabolite concentrations such as carbon dioxide or oxygen. This phenomenon, termed the cerebral vasomotor reactivity (CVMR), is the basis for blood flow regulation in the brain in accordance with its metabolic status. Typically, CVMR is determined as the amount of change in cerebral blood flow in response to a vasodilating stimulus, which can be measured by various neuroimaging methods or by transcranial Doppler. It has been shown that CVMR is impaired in cerebrovascular diseases, but there is also evidence of a similar dysfunction in neurodegenerative disorders...
August 5, 2016: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/27515805/efficacy-of-menopausal-hormone-therapy-on-sleep-quality-systematic-review-and-meta-analysis
#15
Dahima Cintron, Melissa Lipford, Laura Larrea-Mantilla, Gabriela Spencer-Bonilla, Robin Lloyd, Michael R Gionfriddo, Shalak Gunjal, Ann M Farrell, Virginia M Miller, Mohammad Hassan Murad
Sleep complaints are reported by 40-60 % of menopausal women. Poor sleep is a risk factor for cardiovascular disease, diabetes, and obesity. The effect of menopausal hormone therapy on sleep quality is unclear. A systematic review and meta-analysis were conducted to summarize the efficacy of menopausal hormone therapy on self-reported sleep quality. Electronic databases (PubMed, Scopus, Ovid MEDLINE, EMBASE, EBM Reviews CENTRAL, and PsycInfo) were searched from 2002 to October 2015. Randomized trials assessing the effect of menopausal hormone therapy with a minimum follow up of 8 weeks were included...
August 11, 2016: Endocrine
https://www.readbyqxmd.com/read/27497093/prevalence-of-coronary-macro-and-micro-vascular-dysfunctions-after-drug-eluting-stent-implantation-without-in-stent-restenosis
#16
Seiji Hokimoto, Noriaki Tabata, Kenshi Yamanaga, Daisuke Sueta, Tomonori Akasaka, Kenichi Tsujita, Kenji Sakamoto, Eiichiro Yamamoto, Megumi Yamamuro, Yasuhiro Izumiya, Koichi Kaikita, Sunao Kojima, Kunihiko Matsui, Hisao Ogawa
BACKGROUND: The aim was to examine the prevalence and characteristics of epicardial vasomotor abnormality (EVA) and coronary microvascular dysfunction (CMD) including endothelium-dependent (EDCMD) or -independent (EICMD) in patients following a second-generation drug-eluting stent (second DES) implantation without in-stent restenosis. METHODS AND RESULTS: In 105 patients who underwent second DES implantation in the left anterior descending coronary artery (74 men; mean age, 67...
November 1, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27492917/management-of-hormone-deprivation-symptoms-after-cancer
#17
REVIEW
Stephanie S Faubion, Charles L Loprinzi, Kathryn J Ruddy
Cancer survivors often experience symptoms related to hormone deprivation, including vasomotor symptoms, genitourinary symptoms, and sexual health concerns. These symptoms can occur due to natural menopause in midlife women, or they can be brought on by oncologic therapies in younger women or men. We searched PubMed for English-language studies from January 1990 through January 2016 to identify relevant articles on the management of hormone deprivation symptoms, including vasomotor, genitourinary, and sexual symptoms in patients with cancer...
August 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/27391040/dipeptidyl-peptidase-4-inhibition-with-linagliptin-prevents-western-diet-induced-vascular-abnormalities-in-female-mice
#18
Camila Manrique, Javad Habibi, Annayya R Aroor, James R Sowers, Guanghong Jia, Melvin R Hayden, Mona Garro, Luis A Martinez-Lemus, Francisco I Ramirez-Perez, Thomas Klein, Gerald A Meininger, Vincent G DeMarco
BACKGROUND: Vascular stiffening, a risk factor for cardiovascular disease, is accelerated, particularly in women with obesity and type 2 diabetes. Preclinical evidence suggests that dipeptidylpeptidase-4 (DPP-4) inhibitors may have cardiovascular benefits independent of glycemic lowering effects. Recent studies show that consumption of a western diet (WD) high in fat and simple sugars induces aortic stiffening in female C57BL/6J mice in advance of increasing blood pressure. The aims of this study were to determine whether administration of the DPP-4 inhibitor, linagliptin (LGT), prevents the development of aortic and endothelial stiffness induced by a WD in female mice...
July 8, 2016: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/27364144/assessment-of-autonomic-function-in-a-cohort-of-patients-with-anca-associated-vasculitis
#19
P Moog, O Eren, M Witt, V Rauschel, S Kossegg, A Straube, M Grünke, H Schulze-Koops
OBJECTIVE: To assess symptoms and objective parameters of autonomic dysfunction (AD) in patients with ANCA-associated vasculitides. METHODS: Symptoms and objective parameters of AD were assessed in patients with ANCA-associated vasculitis and in age-matched healthy controls. Autonomic symptoms were explored by COMPASS31, a validated questionnaire addressing symptoms of six autonomic domains (orthostatic, vasomotor, secretomotor, gastrointestinal, pupillomotor, and bladder dysfunction)...
August 2016: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/27300032/effects-of-nutraceuticals-on-quality-of-life-and-sexual-function-of-perimenopausal-women
#20
S Caruso, S Cianci, M Cariola, V Fava, A Rapisarda, A Cianci
PURPOSE: The aim of the study was to evaluate the effects of nutraceuticals containing Equol, Resveratrol, Quecitine and Passiflora (Zemiar(®), Avantgarde, Pomezia, Rome, Italy) on quality of life (QoL) and sexual function in perimenopausal women. METHODS: Sixty perimenopausal women having vasomotor symptoms and being in the -1, +1a of the STRAW system (amenorrhea for longer than 60 days and FSH < 20 UI/L) were enrolled. The modified Kupperman Index (KI) was used to evaluate menopause symptoms...
June 14, 2016: Journal of Endocrinological Investigation
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