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https://www.readbyqxmd.com/read/29558039/analysis-of-peripheral-nerve-and-autonomic-nervous-system-function-and-the-stage-of-microangiopathy-in-patients-with-secondary-raynaud-s-phenomenon-in-the-course-of-connective-tissue-diseases
#1
Izabela Gosk-Bierska, Maria Misterska-Skóra, Marta Wasilewska, Małgorzata Bilińska, Jerzy Gosk, Rajmund Adamiec, Magdalena Koszewicz
BACKGROUND: The pathogenesis of secondary Raynaud's phenomenon (SRP) associated with connective tissue diseases (CTD) is not entirely understood. Nervous system dysfunction and microangiopathy are considered to be causes of this pathology. OBJECTIVES: Peripheral and autonomic nervous system function, the stage of microangiopathy, and the relationships between these in patients with SRP were analyzed. MATERIAL AND METHODS: In the study, 20 patients with CTD-related SRP and 30 healthy controls were subject to capillaroscopy, standard conduction velocity tests and conduction velocity distribution (CVD) tests in ulnar and peroneal nerves, heart rate variability (HRV), and sympathetic skin response (SSR) tests...
March 20, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29530988/deletion-of-the-cold-thermoreceptor-trpm8-increases-heat-loss-and-food-intake-leading-to-reduced-body-temperature-and-obesity-in-mice
#2
Alfonso Reimúndez, Carlos Fernández-Peña, Guillermo García, Rubén Fernández, Purificación Ordás, Rosalía Gallego, José L Pardo-Vazquez, Victor Arce, Félix Viana, Rosa Señarís
The coupling of energy homeostasis to thermoregulation is essential to maintain homeothermy in changing external environments. We studied the role of the cold thermoreceptor TRPM8 in this interplay in mice of both sexes. We demonstrate that TRPM8 is required for a precise thermoregulation in response to cold, in fed and fasting. Trpm8-/- mice exhibited a fall of 0.7 °C in core body temperature (Tc) when housed at cold temperatures, and a deep hypothermia (below 30 °C) during food deprivation. In both situations TRPM8-deficiency induced an increase in tail heat loss...
March 12, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29484993/the-use-of-antidepressants-for-physical-and-psychological-symptoms-in-cancer
#3
Syahrir Zaini, N G Chong Guan, Ahmad Hatim Sulaiman, Nor Zuraida Zainal, Hasniza Zaman Huri, Siti Hadijah Shamsudin
: Cancer patients are commonly associated with various physical and psychological symptoms. In view of this matter, palliative care is usually given to relieve those symptoms, improve quality of life, and increase medication adherence. Antidepressants are generally accepted for the treatment of depression among patients with or without cancer. Some other potential benefits of these medications have been experienced in clinical practice. Therefore, this study aimed to review the use of antidepressant for physical and psychological symptoms in cancer...
February 26, 2018: Current Drug Targets
https://www.readbyqxmd.com/read/29459465/mental-stress-induced-myocardial-ischemia-in-young-patients-with-recent-myocardial-infarction-sex-differences-and-mechanisms
#4
Viola Vaccarino, Samaah Sullivan, Muhammad Hammadah, Kobina Wilmot, Ibhar Al Mheid, Ronnie Ramadan, Lisa Elon, Pratik M Pimple, Ernest V Garcia, Jonathon Nye, Amit J Shah, Ayman Alkhoder, Oleksiy Levantsevych, Hawkins Gay, Malik Obideen, Minxuan Huang, Tené T Lewis, J Douglas Bremner, Arshed A Quyyumi, Paolo Raggi
BACKGROUND: Mental stress-induced myocardial ischemia (MSIMI) is frequent in patients with coronary artery disease and is associated with worse prognosis. Young women with a previous myocardial infarction (MI), a group with unexplained higher mortality than men of comparable age, have shown elevated rates of MSIMI, but the mechanisms are unknown. METHODS: We studied 306 patients (150 women and 156 men) ≤61 years of age who were hospitalized for MI in the previous 8 months and 112 community controls (58 women and 54 men) frequency matched for sex and age to the patients with MI...
February 20, 2018: Circulation
https://www.readbyqxmd.com/read/29407125/the-emergence-of-the-coronary-vasomotor-dysfunction-era
#5
EDITORIAL
John F Beltrame
No abstract text is available yet for this article.
March 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29406426/history-of-vasomotor-symptoms-extent-of-coronary-artery-disease-and-clinical-outcomes-after-acute-coronary-syndrome-in-postmenopausal-women
#6
Luca A Ferri, Nuccia Morici, Giorgio Bassanelli, Nicoletta Franco, Leonardo Misuraca, Laura Lenatti, Emilia Lo Jacono, Chiara Leuzzi, Elena Corrada, Tiziana C Aranzulla, Delia Colombo, Angelo Cagnacci, Francesco Prati, Stefano Savonitto
OBJECTIVE: Vasomotor symptoms (VMS) during menopausal transition have been linked to a higher burden of cardiovascular risk factors, subclinical vascular disease, and subsequent vascular events. We aim to investigate the association of VMS with the extent of coronary disease and their prognostic role after an acute coronary syndrome. METHODS: The Ladies Acute Coronary Syndrome study enrolled consecutive women with an acute coronary syndrome undergoing coronary angiography...
February 5, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29396368/liver-specific-rescuing-of-ceacam1-reverses-endothelial-and-cardiovascular-abnormalities-in-male-mice-with-null-deletion-of-ceacam1-gene
#7
Lucia Russo, Harrison T Muturi, Hilda E Ghadieh, Alexander M Wisniewski, Eric E Morgan, Syed S Quadri, Gavin P Landesberg, Helmy M Siragy, Guillermo Vazquez, Rosario Scalia, Rajesh Gupta, Sonia M Najjar
OBJECTIVE: Mice with global null mutation of Ceacam1 (Cc1-/-), display impairment of insulin clearance that causes hyperinsulinemia followed by insulin resistance, elevated hepatic de novo lipogenesis, and visceral obesity. In addition, they manifest abnormal vascular permeability and elevated blood pressure. Liver-specific rescuing of Ceacam1 reversed all of the metabolic abnormalities in Cc1-/-liver+ mice. The current study examined whether Cc1-/- male mice develop endothelial and cardiac dysfunction and whether this relates to the metabolic abnormalities caused by defective insulin extraction...
January 26, 2018: Molecular Metabolism
https://www.readbyqxmd.com/read/29344373/multianalysis-with-optical-coherence-tomography-and-vasomotion-in-everolimus-eluting-stents-and-everolimus-eluting-biovascular-scaffolds-the-moves-trial
#8
Diego A Arroyo, Sara Schukraft, Zacharenia Kallinikou, Jean-Christophe Stauffer, Gérard Baeriswyl, Jean-Jacques Goy, Mario Togni, Stéphane Cook, Serban Puricel
Aims: To compare endothelium-dependent vasomotor function and vascular healing 15 months after implantation of two new-generation drug-eluting stents and biovascular scaffolds (BVS). Methods and results: A total of 28 patients previously treated with a SYNERGY stent (bioabsorbable polymer everolimus-eluting stents (BP-EES)), a PROMUS stent (persistent polymer everolimus-eluting stents (PP-EES)) or an ABSORB (BVS) underwent control coronary angiography, 15 months after implantation, coupled with optical coherence tomography imaging and supine bicycle exercise...
2018: Open Heart
https://www.readbyqxmd.com/read/29314641/chronic-total-occlusion-does-anti-platelet-choice-impact-outcomes
#9
EDITORIAL
Wassim Shatila, Zvonimir Krajcer
Chronic total occlusion (CTO) is associated with worse outcomes compared to non CTO percutaneous coronary intervention (PCI). CTO might be associated with vasomotor dysfunction Ticagrelor is a novel P2Y12 inhibitor that increases local adenosine The TIGER-BVS trial plans to assess the impact of using ticagrelor vs. clopidogrel on vasomotor activity and outcomes after successful CTO PCI.
January 1, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29286527/experience-of-correcting-endothelial-dysfunction-in-children-residents-of-radioactively-contaminated-areas-by-nitric-oxide-potential-donator-citrulline
#10
Ye I Stepanova, I Ye Kolpakov, V M Zygalo, V Yu Vdovenko, V H Kondrashova, O S Leonovich, V V Kryzhanivska
OBJECTIVE: to determine the effectiveness of citrulline use for correcting endothelial dysfunction in children resi dents of radioactively contaminated areas. MATERIALS AND METHODS: A group of children residents of radioactively contaminated areas with the presence of clinical and paraclinical signs of endothelial dysfunction was selected to assess the effectiveness of correcting endothelial dysfunction by the usage of NO potential donator - citrulline according to the data of selective screen ing...
December 2017: Problemy Radiat︠s︡iĭnoï Medyt︠s︡yny Ta Radiobiolohiï
https://www.readbyqxmd.com/read/29282326/neurocognitive-functioning-and-cerebrovascular-reactivity-after-carotid-endarterectomy
#11
Simona Lattanzi, Luciano Carbonari, Gabriele Pagliariccio, Marco Bartolini, Claudia Cagnetti, Giovanna Viticchi, Laura Buratti, Leandro Provinciali, Mauro Silvestrini
OBJECTIVE: To evaluate in patients with TIA and ipsilateral high-grade internal carotid artery (ICA) stenosis whether changes in cognitive performance and cerebral hemodynamics occurred after carotid endarterectomy (CEA) and to explore their relationship. METHODS: Participants were patients who underwent CEA, had TIA within the last 6 months, and had an ipsilateral severe ICA stenosis. Coloured Progressive Matrices (CPM) plus Complex Figure Copy Test (CFCT) and phonemic (ph) plus categorical (ca) Verbal Fluency (VF) tests were performed to assess right and left hemisphere cognitive functions, respectively...
January 23, 2018: Neurology
https://www.readbyqxmd.com/read/29278623/depression-and-heart-diseases-leading-health-problems
#12
Matea Raič
Depression is the most common psychiatric disorder in the world population and the most frequent mental disorder in a primary health care. Unrecognized and untreated depression is associated with a poor outcome of treated chronic diseases which co-exist with depression. Depression and cardiovascular diseases are bidirectional related conditions, risks are for each other, and they often co-exist. Depression is a common disorder in cardiovascular patients with a prevalence of 20% to 45%, which is much more frequent than in the general population...
December 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/29273789/widespread-coronary-dysfunction-in-the-absence-of-hdl-receptor-sr-b1-in-an-ischemic-cardiomyopathy-mouse-model
#13
James T Pearson, Misa Yoshimoto, Yi Ching Chen, Rohullah Sultani, Amanda J Edgley, Hajime Nakaoka, Makoto Nishida, Keiji Umetani, Mark T Waddingham, Hui-Ling Jin, Yuan Zhang, Darren J Kelly, Daryl O Schwenke, Tadakatsu Inagaki, Hirotsugu Tsuchimochi, Issei Komuro, Shizuya Yamashita, Mikiyasu Shirai
Reduced clearance of lipoproteins by HDL scavenger receptor class B1 (SR-B1) plays an important role in occlusive coronary artery disease. However, it is not clear how much microvascular dysfunction contributes to ischemic cardiomyopathy. Our aim was to determine the distribution of vascular dysfunction in vivo in the coronary circulation of male mice after brief exposure to Paigen high fat diet, and whether this vasomotor dysfunction involved nitric oxide (NO) and or endothelium derived hyperpolarization factors (EDHF)...
December 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29273448/-pain-in-children-with-neurological-impairment-a-review-from-the-french-pediatric-neurology-society
#14
J Avez-Couturier, S Joriot, S Peudenier, D Juzeau
Management of pain is one of the major expectations of children with neurological impairment and their families. The medical literature is poor on this topic accounting for approximately 0.15 % of the publications on pain in general. The objective of the French Pediatric Neurology Society was to review the current knowledge on this topic. Bibliographic research was conducted with PubMed and RefDoc for publications between 1994 and 2014 in French or English. A total of 925 articles were retrieved and 92 were selected for review...
January 2018: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/29241313/hormonal-treatment-and-quality-of-life-of-prostate-cancer-patients-new-evidence
#15
Marcello Tucci, Gianmarco Leone, Consuelo Buttigliero, Clizia Zichi, Rosario F DI Stefano, Daniele Pignataro, Francesca Vignani, Giorgio V Scagliotti, Massimo DI Maio
Androgen deprivation therapy (ADT) is the mainstay of treatment of patients with relapsed or metastatic hormone-sensitive prostatic carcinoma. The dramatic reduction of serum testosterone levels induced by ADT produces multiple side effects as vasomotor flushing, sexual dysfunction, fatigue, impairment of cognitive function, reduced quality of sleep, gynecomastia and anemia, that are able to decrease health-related quality of life (QoL). In addition, hormonal therapy can interfere with bone metabolism and induce metabolic and cardiovascular complications...
April 2018: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/29240052/-assessment-of-endothelial-dysfunction-for-prevention-of-complications-in-patients-with-lesions-of-peripheral-arteries
#16
A V Pokrovskiĭ, V A Kul'bak, T A Kremenchugskaia, E E Fedorov
BACKGROUND: Severity of endothelial dysfunction and impairments of the vasomotor function of arteries correlate with the degree of the development of atherosclerosis and the risk of cardiovascular complications. To date, poorly studied still remains the problem concerning alteration of the regulatory function of the endothelium in patients diagnosed with pronounced atherosclerotic lesions of peripheral arteries, as well as the impact of a surgical intervention on indices of endothelial dysfunction...
2017: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/29227723/interventions-to-address-sexual-problems-in-people-with-cancer-american-society-of-clinical-oncology-clinical-practice-guideline-adaptation-of-cancer-care-ontario-guideline
#17
Jeanne Carter, Christina Lacchetti, Barbara L Andersen, Debra L Barton, Sage Bolte, Shari Damast, Michael A Diefenbach, Katherine DuHamel, Judith Florendo, Patricia A Ganz, Shari Goldfarb, Sigrun Hallmeyer, David M Kushner, Julia H Rowland
Purpose The adaptation of the Cancer Care Ontario (CCO) guideline Interventions to Address Sexual Problems in People With Cancer provides recommendations to manage sexual function adverse effects that occur as a result of cancer diagnosis and/or treatment. Methods ASCO staff reviewed the guideline for developmental rigor and updated the literature search. An ASCO Expert Panel ( Table A1 ) was assembled to review the guideline content and recommendations. Results The ASCO Expert Panel determined that the recommendations from the 2016 CCO guideline are clear, thorough, and based upon the most relevant scientific evidence...
February 10, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29212858/decreased-edhf-mediated-relaxation-is-a-major-mechanism-in-endothelial-dysfunction-in-resistance-arteries-in-aged-mice-on-prolonged-high-fat-sucrose-diet
#18
Shannon M Dunn, Robert H Hilgers, Kumuda C Das
High-fat sucrose (HFS) diet in aged individuals causes severe weight gain (obesity) with much higher risk of cardiovascular diseases such as hypertension or atherosclerosis. Endothelial dysfunction is a major contributor for these vascular disorders. We hypothesize that prolonged ingestion of HFS diet by aged mice would accentuate endothelial dysfunction in the small resistance arteries. Male C57BL/6J mice at 12 weeks of age were divided into four groups and fed either normal chow (NC) or high-fat sucrose diet (HFS)...
December 2017: Physiological Reports
https://www.readbyqxmd.com/read/29169760/coronary-vasomotor-dysfunction-in-apical-ballooning-takotsubo-syndrome-an-innocent-bystander-or-a-prime-suspect
#19
EDITORIAL
Mohammed A Al-Hijji, Abhiram Prasad
No abstract text is available yet for this article.
January 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29169759/abnormal-coronary-vasoreactivity-in-transient-left-ventricular-apical-ballooning-tako-tsubo-syndrome
#20
Edoardo Verna, Stefano Provasoli, Sergio Ghiringhelli, Fabrizio Morandi, Jorge Salerno-Uriarte
BACKGROUND: The exact etiology and pathophysiologic mechanisms of tako-tsubo syndrome (TTS) remain controversial. OBJECTIVE: To further evaluate the abnormal coronary vasoreactivity and its possible anatomical substrate in TTS. METHODS: We studied 47 patients (46 women; age 67±12years) who underwent diagnostic cardiac catheterization and evaluation of coronary vasoreactivity by sequential acetylcholine (Ach), nitroglycerine and adenosine testing with angiographic and intracoronary pressure-Doppler flow monitoring...
January 1, 2018: International Journal of Cardiology
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