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Kellgren lawrence knee hip

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https://www.readbyqxmd.com/read/29139573/gait-patterns-symptoms-and-function-in-patients-with-isolated-tibiofemoral-osteoarthritis-and-combined-tibiofemoral-and-patellofemoral-osteoarthritis
#1
Harvi F Hart, Kay M Crossley, Michael A Hunt
The purpose of this study was to compare hip and knee biomechanics during walking in individuals with isolated TFOA, combined TFOA and PFOA, and those without knee OA, and to compare patient-reported symptoms and function in individuals with isolated TFOA and those with combined TFOA and PFOA. Participants with and without knee OA were assessed and categorized into (i) no OA, (ii) isolated TFOA, and (iii) combined TFOA and PFOA, based on Kellgren and Lawrence diagnostic criteria. Quantitative motion analyses were conducted during walking, and hip and knee kinematics and external moments were calculated...
November 15, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29105498/can-adipokines-serum-levels-be-used-as-biomarkers-of-hand-osteoarthritis
#2
A Fioravanti, S Cheleschi, A De Palma, O Addimanda, L Mancarella, E Pignotti, L Pulsatelli, M Galeazzi, R Meliconi
PURPOSE: To evaluate serum levels of visfatin, resistin and adiponectin in patients with erosive (E) and non-erosive (NE) osteoarthritis (OA) of the hand (HOA) compared to normal controls (NC). METHODS: 94 outpatients with E HOA and NE HOA and 21 NC were enrolled. The radiological assessment of both hands was performed according to the Kellgren-Lawrence and Kallman score. Patients were divided into two subsets (lone HOA or generalized OA) based on clinically OA involvement of knee and hip...
November 5, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28946838/randomized-controlled-trial-comparing-efficacy-of-conventional-and-new-single-larger-dose-of-intra-articular-viscosupplementation-in-management-of-knee-osteoarthritis
#3
Vijaya Kumar L Suppan, Chew Yu Wei, Tan Chin Siong, Tew Mei Mei, Wong Bor Chern, Vijay Kumar Nanta Kumar, Kee Rong Sheng, Ashutosh Sadashiva Rao
BACKGROUND: Intra-articular hyaluronic acid (HA) injection is used in management of knee, hand and hip osteoarthritis. While HA injection is included in the list of evaluated therapies, its efficacy and optimum dosing still have no consensus. This study was conducted to explore the possibility of using single injection HA to increase patient convenience while maintaining the therapeutic efficacy. METHODS: We present a prospective, open label, non-blinded, randomized controlled trial performed in accordance with guidelines in principles of good clinical practice...
September 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28760738/characteristics-associated-with-joint-replacement-in-early-symptomatic-knee-or-hip-osteoarthritis-6-year-results-from-a-nationwide-prospective-cohort-study-check
#4
Alex N Bastick, Jurgen Damen, Rintje Agricola, Reinoud W Brouwer, Patrick Je Bindels, Sita Ma Bierma-Zeinstra
BACKGROUND: Many patients with osteoarthritis (OA) of the knee and/or hip undergo total joint replacement (TJR) because of severely progressed symptoms. AIM: To determine patient and disease characteristics associated with undergoing TJR in participants with recent-onset knee and/or hip OA. DESIGN AND SETTING: Participants with hip or knee pain from the nationwide prospective Cohort Hip and Cohort Knee (CHECK) study were included. METHOD: The outcome measure was total hip arthroplasty (THA) or total knee arthroplasty (TKA) during 6 years of follow-up...
July 31, 2017: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/28757188/a-sex-specific-association-between-incident-radiographic-osteoarthritis-of-hip-or-knee-and-incident-peripheral-arterial-calcifications-8-year-prospective-data-from-cohort-hip-and-cohort-knee-check
#5
W P Gielis, P M J Welsing, W E van Spil, J Runhaar, H Weinans, P A de Jong
OBJECTIVES: There is sparse evidence for a relationship between cardiovascular disease (CVD) and osteoarthritis (OA). We investigated the association between incidence of arterial calcifications and incidence of radiographic knee and/or hip OA. DESIGN: We used baseline and 8-year follow-up data of Cohort Hip and Cohort Knee (CHECK). Knees and hips were either Kellgren-Lawrence (KL) grade 0 or 1 at baseline. Arterial calcifications were scored on hip and knee radiographs using a four-grade scale...
July 28, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28755495/identification-of-good-candidates-for-valgus-bracing-as-a-treatment-for-medial-knee-osteoarthritis
#6
Allison L Clouthier, Elizabeth A Hassan, Scott C E Brandon, Aaron Campbell, Michael J Rainbow, Kevin J Deluzio
Valgus unloader braces are a conservative treatment option for medial compartment knee osteoarthritis that aim to unload the damaged medial compartment through application of an external abduction moment. Patient response to bracing is highly variable, however. While some experience improvements in pain, function, and joint loading, others receive little to no benefit. The objective of this work was to analyze clinical measures and biomechanical characteristics of unbraced walking to identify variables that are associated with the mechanical effectiveness of valgus unloader bracing...
July 29, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28737953/metabolic-factors-and-oxidative-stress-in-osteoarthritis-a-case-control-study
#7
Kaspar Tootsi, Aare Märtson, Jaak Kals, Kaido Paapstel, Mihkel Zilmer
Previous studies suggest that metabolic disturbances might be involved in the development of osteoarthritis (OA). Associations have been found between the individual components of metabolic syndrome (MetS) and OA. MetS has been associated with increased oxidative stress (OxS). The study aimed to clarify the role of MetS components in OA and to evaluate the levels of OxS in OA patients and in age-matched controls. Fifty-five patients with end-stage OA (age 63 ± 7 years) prior to hip or knee joint replacement surgery and 55 age-, gender- and body mass index matched controls (61 ± 8 years) were enrolled in the study...
July 24, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/28560544/profile-of-osteoarthritic-patients-undergoing-hip-or-knee-arthroplasty-a-step-toward-a-definition-of-the-need-for-surgery
#8
Audrey Neuprez, Arnaud H Neuprez, William Kurth, Philippe Gillet, Olivier Bruyère, Jean-Yves Reginster
AIMS: The objective of this study is to characterize, based on clinical, radiographic, health-related, quality-of-life-related, and demographic variables, the profile of a large, homogeneous, cohort of patients undergoing knee or hip arthroplasty, in a public hospital. Current regulatory guidelines for structure-modifying agent are not clear regarding hard clinical endpoint. The "need for surgery" has been suggested as a potential relevant outcome, but, until now, it is poorly defined...
May 30, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28546767/increase-and-regulation-of-synovial-calcitonin-gene-related-peptide-expression-in-patients-with-painful-knee-osteoarthritis
#9
Shotaro Takano, Kentaro Uchida, Gen Inoue, Atsushi Minatani, Masayuki Miyagi, Jun Aikawa, Dai Iwase, Kenji Onuma, Manabu Mukai, Masashi Takaso
BACKGROUND: Recent studies suggest that the vasodilatory neuropeptide calcitonin gene-related peptide (CGRP) is localized in the synovial tissue and may be involved in the pathology of hip and knee osteoarthritis (OA). However, the regulation and relationship between pain and CGRP expression levels in the synovial tissue of human OA patients are not fully understood. METHODS: Synovial tissues were harvested from 74 participants with radiographic knee OA (unilateral Kellgren/Lawrence grades 3-4) during total knee arthroplasty...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28493422/differences-in-presentation-progression-and-rates-of-arthroplasty-between-hip-and-knee-osteoarthritis-observations-from-an-osteoarthritis-cohort-study-a-clear-role-for-conservative-management
#10
Chamila Dabare, Kim Le Marshall, Albert Leung, Carolyn J Page, Peter F Choong, Keith K Lim
AIM: To describe the natural progression and the rates of arthroplasty of a cohort of hip and knee osteoarthritis (OA) patients. METHODS: An observational study of 247 consecutive patients who attended an OA clinic between May 2008 and August 2009. Follow-up survey was conducted from July 2014 to December 2014, with the primary end point being joint replacement surgery. RESULTS: One hundred and sixty-seven patients had knee OA and 80 patients had hip OA...
October 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28359929/asymptomatic-radiographic-hip-osteoarthritis-is-associated-with-gait-differences-especially-in-women-a-population-based-study
#11
Vincentius J A Verlinden, Marjolein de Kruijf, Sita M A Bierma-Zeinstra, Albert Hofman, André G Uitterlinden, M Arfan Ikram, Joyce B J van Meurs, Jos N van der Geest
BACKGROUND: Hip and knee osteoarthritis (OA) are debilitating diseases that impair gait at severe stages. Although associations between OA and gait are established for normal walking, little is known about its relation with turning and tandem (heel-to-toe) walking. Furthermore, it is unknown how asymptomatic OA associates with gait, and whether associations differ by sex. We investigated how symptomatic and asymptomatic hip and knee OA associate with gait in community-dwelling individuals...
March 16, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28197696/large-meniscus-extrusion-ratio-is-a-poor-prognostic-factor-of-conservative-treatment-for-medial-meniscus-posterior-root-tear
#12
Yoon-Ho Kwak, Sahnghoon Lee, Myung Chul Lee, Hyuk-Soo Han
PURPOSE: The purpose of this study was to find a prognostic factor of medial meniscus posterior root tear (MMPRT) for surgical decision making. METHODS: Eighty-eight patients who were diagnosed as acute or subacute MMPRT without severe degeneration of the meniscus were treated conservatively for 3 months. Fifty-seven patients with MMPRT showed good response to conservative treatment (group 1), while the remaining 31 patients who failed to conservative treatment (group 2) received arthroscopic meniscus repair...
February 15, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28129489/bone-mineral-density-and-the-risk-of-hip-and-knee-osteoarthritis-the-johnston-county-osteoarthritis-project
#13
Kamil E Barbour, Louise B Murphy, Charles G Helmick, Jennifer M Hootman, Jordan B Renner, Joanne M Jordan
OBJECTIVE: To address knowledge gaps regarding the relationship between bone mineral density (BMD) and incident hip or knee osteoarthritis (OA); specifically, lack of information regarding hip OA or symptomatic outcomes. METHODS: Using data (n = 1,474) from the Johnston County Osteoarthritis Project's first (1999-2004) and second (2005-2010) followup of participants ages ≥45 years, we examined the association between total hip BMD and both hip and knee OA. Total hip BMD was measured using dual x-ray absorptiometry, and participants were classified into sex-specific quartiles (low, intermediate low, intermediate high, and high)...
January 27, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28028160/predictive-value-of-mri-features-for-development-of-radiographic-osteoarthritis-in-a-cohort-of-participants-with-pre-radiographic-knee-osteoarthritis-the-check-study
#14
Kim van Oudenaarde, Björn Jobke, Ans C M Oostveen, Annekarien C A Marijnissen, Ron Wolterbeek, Janet Wesseling, Sita M A Bierma-Zeinstra, Hans L Bloem, Monique Reijnierse, Margreet Kloppenburg
OBJECTIVE: To determine whether MRI features are associated with development of radiographic knee OA and can be used as a predictive tool in early knee OA. METHODS: In 148 participants of the Cohort Hip and Cohort Knee study (mean age 56 years, 78% women), with a Kellgren Lawrence (KL) score ⩽1, we obtained semi-quantitatively scored knee MRI scans and radiographs at baseline. After 5 years, we determined the development of radiographic knee OA (KL ⩾2). We calculated odds ratios (ORs), with 95% CIs adjusted for age, sex and BMI, to identify MRI features associated with OA development...
January 2017: Rheumatology
https://www.readbyqxmd.com/read/27894173/open-wedge-high-tibial-osteotomy-and-combined-arthroscopic-surgery-in-severe-medial-osteoarthritis-and-varus-malalignment-minimum-5-year-results
#15
Moon-Jib Yoo, Yong-Eun Shin
Purpose: To evaluate the radiologic and functional outcomes of medial open wedge high tibial osteotomy (HTO) combined with arthroscopic procedure in patients with medial osteoarthritis. Materials and Methods: From June 1996 to March 2010, 26 patients (32 knees) who underwent medial open wedge osteotomy and arthroscopic operation for medial osteoarthritis were retrospectively reviewed. Measurements included hip-knee-ankle (HKA) angle, femorotibial angle, medial proximal tibial angle, posterior tibial slope angle, and Kellgren-Lawrence grade...
December 1, 2016: Knee Surgery & related Research
https://www.readbyqxmd.com/read/27864563/a-replication-study-and-meta-analysis-of-mitochondrial-dna-variants-in-the-radiographic-progression-of-knee-osteoarthritis
#16
Mercedes Fernández-Moreno, Angel Soto-Hermida, María E Vázquez-Mosquera, Estefanía Cortés-Pereira, Sonia Pértega, Sara Relaño, Natividad Oreiro-Villar, Carlos Fernández-López, Francisco J Blanco, Ignacio Rego-Pérez
OBJECTIVE: To conduct a replication study and meta-analysis involving the study of mtDNA variants in the radiographic progression of OA in different cohorts worldwide, including Cohort Hip and Cohort Knee (CHECK), the OA Initiative and a cohort from Spain. METHODS: The influence of the haplogroups in the rate of radiographic progression at 96 months in 431 subjects from CHECK was assessed in terms of Kellgren and Lawrence (KL) grade. Progression was defined as a change from KL ⩾ 1 at baseline to any higher grade during the follow-up...
February 2017: Rheumatology
https://www.readbyqxmd.com/read/27751171/activation-of-calcitonin-gene-related-peptide-signaling-through-the-prostaglandin-e2-ep1-ep2-ep4-receptor-pathway-in-synovium-of-knee-osteoarthritis-patients
#17
Atsushi Minatani, Kentaro Uchida, Gen Inoue, Shotaro Takano, Jun Aikawa, Masayuki Miyagi, Hisako Fujimaki, Dai Iwase, Kenji Onuma, Toshihide Matsumoto, Masashi Takaso
BACKGROUND: Calcitonin gene-related peptide (CGRP) is a 37-amino-acid vasodilatory neuropeptide that binds to receptor activity-modifying protein 1 (RAMP1) and the calcitonin receptor-like receptor (CLR). Clinical and preclinical evidence suggests that CGRP is associated with hip and knee joint pain; however, the regulation mechanisms of CGRP/CGRP receptor signaling in synovial tissue are not fully understood. METHODS: Synovial tissues were harvested from 43 participants with radiographic knee osteoarthritis (OA; unilateral Kellgren/Lawrence (K/L) grades 3-4) during total knee arthroplasty...
October 17, 2016: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/27746495/epidemiology-of-knee-osteoarthritis-in-india-and-related-factors
#18
Chandra Prakash Pal, Pulkesh Singh, Sanjay Chaturvedi, Kaushal Kumar Pruthi, Ashok Vij
BACKGROUND: Among the chronic rheumatic diseases, hip and knee osteoarthritis (OA) is the most prevalent and is a leading cause of pain and disability in most countries worldwide. Its prevalence increases with age and generally affects women more frequently than men. OA is strongly associated with aging and heavy physical occupational activity, a required livelihood for many people living in rural communities in developing countries. Determining region-specific OA prevalence and risk factor profiles will provide important information for planning future cost effective preventive strategies and health care services...
September 2016: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/27648573/radiographic-hip-or-knee-osteoarthritis-and-the-ability-to-drive
#19
Maximilian von Bernstorff, Martina Feierabend, Maurice Jordan, Christopher Glatzel, Ingmar Ipach, Ulf Krister Hofmann
The question of whether patients with musculoskeletal disorders are fit to drive is of paramount importance for them and frequently is directed to the treating orthopedic specialist. Although perioperative braking performance has been increasingly investigated in recent years, scientific data on braking safety in individuals with osteoarthritis (OA) are scarce. This study analyzed the braking performance of 158 patients with OA of the right or left knee or hip and compared the results with radiographic OA grading according to the Kellgren-Lawrence classification scale...
January 1, 2017: Orthopedics
https://www.readbyqxmd.com/read/27558412/central-sensitization-as-a-determinant-of-patients-benefit-from-total-hip-and-knee-replacement
#20
V Wylde, A Sayers, A Odutola, R Gooberman-Hill, P Dieppe, A W Blom
BACKGROUND: Discrepancies exist between osteoarthritic joint changes and pain severity before and after total hip (THR) and knee (TKR) replacement. This study investigated whether the interaction between pre-operative widespread hyperalgesia and severity of radiographic osteoarthritis (OA) was associated with pain severity before and after joint replacement. METHODS: Data were analysed from 232 patients receiving THR and 241 receiving TKR. Pain was assessed pre-operatively and at 12 months post-operatively using the WOMAC Pain Scale...
February 2017: European Journal of Pain: EJP
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