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https://www.readbyqxmd.com/read/29775891/protective-effect-of-atorvastatin-meditated-by-hmgcr-gene-on-diabetic-rats-with-atherosclerosis-an-in-vivo-and-in-vitro-study
#1
Yong-Zhi Wang, Lei Yang, Chuan-Fang Li
BACKGROUND: Accelerated atherosclerosis in patients suffering from diabetes represents a major cause of morbidity and mortality. The aim of present study was to investigate the protective effects conferred by atorvastatin (AVT) meditated by the HMGCR gene in diabetic rats with atherosclerosis. METHODS: Serum triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), very-low-density lipoprotein cholesterol (VLDL-C), fasting blood glucose (FBG) and serum insulin (INS) were all determined by means of in vivo experiments...
May 15, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29775853/an-ultrasensitive-electrochemiluminescence-biosensor-for-detection-of-microrna-by-in-situ-electrochemically-generated-copper-nanoclusters-as-luminophore-and-tio-2-as-coreaction-accelerator
#2
Hongxia Liao, Ying Zhou, Yaqin Chai, Ruo Yuan
Herein, we constructed an ultrasensitive electrochemiluminescence (ECL) biosensor for detecting microRNA-21 (miR-21) based on in-situ generation of copper nanoclusters (Cu NCs) as luminophore and titanium dioxide (TiO2 ) as coreaction accelerator. First, numerous AT-rich double-stranded DNA (dsDNA) was produced from the conversion of a small amount of target miR-21 via the combination of exonuclease III (Exo III)-assisted amplification and hybridization chain reaction (HCR), which could reduce the aggregation-caused self-etching effect of Cu NCs and improve the emitting of Cu NCs...
May 8, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29775839/veterinary-applications-of-pulsed-electromagnetic-field-therapy
#3
REVIEW
James S Gaynor, Sean Hagberg, Blake T Gurfein
Pulsed electromagnetic field (PEMF) therapy can non-invasively treat a variety of pathologies by delivering electric and magnetic fields to tissues via inductive coils. The electromagnetic fields generated by these devices have been found to affect a variety of biological processes and basic science understanding of the underlying mechanisms of action of PEMF treatment has accelerated in the last 10 years. Accumulating clinical evidence supports the use of PEMF therapy in both animals and humans for specific clinical indications including bone healing, wound healing, osteoarthritis and inflammation, and treatment of post-operative pain and edema...
May 7, 2018: Research in Veterinary Science
https://www.readbyqxmd.com/read/29775827/responses-of-atrazine-degradation-and-native-bacterial-community-in-soil-to-arthrobacter-sp-strain-hb-5
#4
Jianpeng Gao, Peipei Song, Guanying Wang, Jinhua Wang, Lusheng Zhu, Jun Wang
The bioremediation of soil contaminated with organic pesticides is a safe and effective approach to remove pollutants from the soil. However, whether the invasion of foreign aid organisms affects the local organisms has received increasing attention in recent years. Therefore, the purpose of this study was to examine the degradation ability of atrazine by the strain HB-5 and evaluate its effects on natural bacterial communities in a miniature pot experiment. Results showed that HB-5 accelerated the degradation of atrazine and the degradation half-life of atrazine was 3...
May 15, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29775710/dual-ph-sensitive-supramolecular-micelles-from-star-shaped-pdmaema-based-on-%C3%AE-cyclodextrin-for-drug-release
#5
Zaishuai Zhou, Feng Guo, Nairong Wang, Meng Meng, Guiying Li
Star-shaped poly(2-(dimethylamino)ethyl methacrylate) based on β-cyclodextrin (β-CD-(PDMAEMA)7 ) was synthesized by means of atomic transfer radical polymerization (ATRP). Dual pH-sensitive supramolecular micelles were formed from β-CD-(PDMAEMA)7 and benzimidazole modified poly(ε-caprolactone) (BM-PCL) through the host-guest interactions between β-CD and benzimidazole. The supramolecular micelles have regular spherical structure with hydrophobic β-CD/BM-PCL as the core and pH-sensitive PDMAEMA as the shell...
May 15, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29775632/controlled-delivery-of-a-focal-adhesion-kinase-inhibitor-results-in-accelerated-wound-closure-with-decreased-scar-formation
#6
Kun Ma, Sun Hyung Kwon, Jagannath Padmanabhan, Dominik Duscher, Artem A Trotsyuk, Yixiao Dong, Mohammed Inayathullah, Jayakumar Rajadas, Geoffrey C Gurtner
Formation of scars following wounding or trauma represents a significant healthcare burden costing the economy billions of dollars every year. Activation of focal adhesion kinase (FAK) has been shown to play a pivotal role in transducing mechanical signals to elicit fibrotic responses and scar formation during wound repair. We have previously shown that inhibition of FAK using local injections of a small molecule FAK inhibitor (FAKI) can attenuate scar development in a hypertrophic scar model. Clinical translation of FAKI therapy has been challenging, however, due to the lack of an effective drug delivery system for extensive burn injuries, blast injuries, and large excisional injuries...
May 15, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29775609/kruppel-like-factor-4-klf-4-plays-a-crucial-role-in-simvastatin-svt-induced-differentiation-of-rabbit-articular-chondrocytes
#7
Seon-Mi Yu, Song Ja Kim
Simvastatin is a cholesterol-lowing reagent that is derived synthetically from the fermentation of Aspergillus terreus. Recently, SVT has been shown to possess a protective effect of chondrocytes. Kruppel-like factor 4 (KLF-4) is a zinc finger transcription factor that plays crucial roles during the development and maintenance of multiple organs. However, the roles of KLF-4 in chondrocytes have not been well unknown. Here, we investigated whether KLF-4 regulates SVT-caused differentiated phenotype of chondrocytes...
May 15, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29775564/the-antibody-rhigm22-facilitates-hippocampal-remyelination-and-ameliorates-memory-deficits-in-the-cuprizone-mouse-model-of-demyelination
#8
Charlene Cui, Jing Wang, Ariana P Mullin, Anthony O Caggiano, Tom J Parry, Raymond W Colburn, Elias Pavlopoulos
Multiple sclerosis (MS) is a chronic, inflammatory demyelinating disease of the CNS. In addition to motor, sensory and visual deficits, MS is also characterized by hippocampal demyelination and memory impairment. We recently demonstrated that a recombinant human-derived monoclonal IgM antibody, which is designated rHIgM22 and currently in clinical development for people with MS, accelerates remyelination of the corpus callosum in the brains of cuprizone-treated mice. Here, we investigated the effects of rHIgM22 in the hippocampus and on hippocampal-dependent learning and memory in the same mouse model of cuprizone-induced demyelination and spontaneous remyelination...
May 15, 2018: Brain Research
https://www.readbyqxmd.com/read/29775561/isolation-and-characterization-of-a-novel-anti-salbutamol-chicken-scfv-for-human-doping-urinalysis
#9
Warren Lee, Syed A Ali, Leow Chiuan Yee, Tan Soo Choon, Leow Chiuan Herng
Anti-salbutamol antibodies remain as important tools for the detection of salbutamol abuse in athletic doping. This study evaluated the feasibility and efficiency of the chicken (Gallus gallus domesticus) as an immunization host to generate anti-salbutamol scFv antibodies by phage display. A phage display antibody library was constructed from a single chicken immunized against salbutamol-KLH conjugate. After a stringent biopanning strategy, a novel scFv clone which was inhibited by free salbutamol recorded the highest affinity...
May 15, 2018: Analytical Biochemistry
https://www.readbyqxmd.com/read/29775553/influence-of-photobiomodulation-therapy-on-gingivitis-induced-by-multi-bracket-appliances-a-split-mouth-randomized-controlled-trial
#10
Steffen Stein, Michael Schauseil, Andreas Hellak, Heike Korbmacher-Steiner, Andreas Braun
OBJECTIVE: The objective of this split-mouth trial was to investigate the influence of photobiomodulation therapy (PBMT) on adjuvant treatment of gingivitis induced by multi-bracket appliances, after bracket debonding and professional tooth cleaning. MATERIALS AND METHODS: Thirteen patients (mean age 16.15 years; standard deviation ±2.12 years) who had completed active orthodontic treatment with fixed orthodontic appliances in an orthodontic clinic were included on a randomized basis...
May 18, 2018: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/29775409/transactivation-domain-of-p53-regulates-dna-repair-and-integrity-in-human-ips-cells
#11
Ramaswamy Kannappan, Saidulu Mattapally, Pooja A Wagle, Jianyi Zhang
The role of p53 transactivation domain (p53-TAD), a multifunctional and dynamic domain, on DNA repair and retaining DNA integrity in human iPS cells has never been studied. p53-TAD was knocked out in iPS cells using CRISPR/Cas9 and was confirmed by DNA sequencing. p53-TAD KO cells were characterized by: accelerated proliferation, decreased population doubling time, and unaltered Bcl2, BBC3, IGF1R, Bax and altered Mdm2, p21, and PIDD transcripts expression. In p53-TAD KO cells p53 regulated DNA repair proteins XPA, DNA polH and DDB2 expression were found to be reduced compared to p53-WT cells...
May 18, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29775363/charge-transfer-processes-in-warm-dense-matter-selective-spectral-filtering-for-laser-accelerated-ion-beams
#12
J Braenzel, M D Barriga-Carrasco, R Morales, M Schnürer
We investigate, both experimentally and theoretically, how the spectral distribution of laser accelerated carbon ions can be filtered by charge exchange processes in a double foil target setup. Carbon ions at multiple charge states with an initially wide kinetic energy spectrum, from 0.1 to 18 MeV, were detected with a remarkably narrow spectral bandwidth after they had passed through an ultrathin and partially ionized foil. With our theoretical calculations, we demonstrate that this process is a consequence of the evolution of the carbon ion charge states in the second foil...
May 4, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29775321/direct-ortho-c-h-aminoalkylation-of-2-substituted-pyridine-derivatives-catalyzed-by-yttrium-complexes-with-n-n-diarylethylenediamido-ligands
#13
Abhinanda Kundu, Mariko Inoue, Haruki Nagae, Hayato Tsurugi, Kazushi Mashima
A mixed ligated amidoyttrium complex, Y(NBn2 )(L1)(THF)2 (8, L1 = N,N'-bis(2,6-diisopropylphenyl)ethylenediamine), served as a catalyst for addition of the ortho-pyridyl C(sp2 )-H bond of 2-substituted pyridines to non-activated imines; complex 8 showed superior catalytic performance compared with Y[N(SiMe3 )2 ]3 (1) and Y[N(SiMe3 )2 ]2 (NBn2 )(THF) (2). Concerning the reaction mechanism, we conducted a stoichiometric reaction of an alkylyttrium complex, Y(CH2 SiMe3 )(L1)(THF)2 (7), with 2-ethylpyridine (4e), giving a mixture of (η3 -pyridylmethyl)yttrium complex 9 and (η2 -pyridyl)yttrium complex 10 along with elimination of SiMe4 ...
May 18, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29775291/reactive-uptake-of-glyoxal-by-ammonium-containing-salt-particles-as-a-function-of-relative-humidity
#14
Masao Gen, Dandan Huang, Chak Keung Chan
Reactions between dissolved ammonia and carbonyls, which form light-absorbing species in atmospheric particles, can be accelerated by actively removing water from the reaction system. Here, we examine the effects of relative humidity (RH) on the reactive uptake of glyoxal (Gly) by aqueous particles of ammonium sulfate (AS), ammonium bisulfate, sodium sulfate, magnesium sulfate, ammonium nitrate (AN), and sodium nitrate. In-situ Raman analysis was used to quantify particle-phase Gly and a colored product, 2,2'-biimidazole (BI) as a function of uptake time...
May 18, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29775210/the-effect-of-simulated-space-radiation-on-the-n-glycosylation-of-human-immunoglobulin-g1
#15
Mate Szarka, Szabolcs Szilasi, Boglarka Donczo, Daniel Sarkozy, Istvan Rajta, Andras Guttman
On a roundtrip to Mars, astronauts are expectedly exposed to an approximate amount of radiation that exceeds the lifetime limits on Earth. This elevated radiation dose is mainly due to Galactic Cosmic Rays (GCR) and Solar Particle Events (SPE). Specific patterns of the N-glycosylation of human immunoglobulins have already been associated with various ailments such as autoimmune diseases, malignant transformation, chronic inflammation and ageing. The focus of our work was to investigate the effect of low-energy proton irradiation on the IgG N-glycosylation profile with the goal if disease associated changes could be detected during space travel and not altered by space radiation...
May 18, 2018: Electrophoresis
https://www.readbyqxmd.com/read/29774739/reconstructing-supramolecular-aggregates-to-nitrogen-deficient-g-c3n4-bunchy-tubes-with-enhanced-photocatalysis-for-h2-production
#16
Guifang Ge, Xinwen Guo, Chunshan Song, Zhongkui Zhao
Developing a facile method to overcome the intrinsic shortcomings of g-C3N4 photocatalyst concerning its insufficient visible-light absorption and dissatisfactory separation efficiency of charge carriers is of great significance but remains a challenge. In this work, we report, for the first time, a sapiential strategy for preparing highly-efficient nitrogen deficient g-C3N4 featuring bunchy microtubes (R-TCN) via a KOH-assisted hydrothermal treatment of rodlike melamine-cyanuric acid supramolecular aggregates (RMCA) followed by heating the reconstructed RMCA, in which KOH serves as an all-rounder for breaking hydrogen bonds, accelerating hydrolysis of melamine and nitrogen defects forming...
May 18, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29774638/loss-of-sirtuin-1-and-mitofusin-2-contributes-to-enhanced-ischemia-reperfusion-injury-in-aged-livers
#17
Sung Kook Chun, Sooyeon Lee, Joseph Flores-Toro, Rebecca Y U, Ming-Jim Yang, Kristina L Go, Thomas G Biel, Catherine E Miney, Schiley Pierre Louis, Brian K Law, Mary E Law, Elizabeth M Thomas, Kevin E Behrns, Christiaan Leeuwenburgh, Jae-Sung Kim
Ischemia/reperfusion (I/R) injury is a causative factor contributing to morbidity and mortality during liver resection and transplantation. Livers from elderly patients have a poorer recovery from these surgeries, indicating reduced reparative capacity with aging. Mechanisms underlying this age-mediated hypersensitivity to I/R injury remain poorly understood. Here, we investigated how sirtuin 1 (SIRT1) and mitofusin 2 (MFN2) are affected by I/R in aged livers. Young (3 months) and old (23-26 months) male C57/BL6 mice were subjected to hepatic I/R in vivo...
May 17, 2018: Aging Cell
https://www.readbyqxmd.com/read/29774542/accelerated-pre-senile-systemic-amyloidosis-in-pacap-knockout-mice-a-protective-role-of-pacap-in-age-related-degenerative-processes
#18
Dora Reglodi, Adel Jungling, Rémi Longuespée, Joerg Kriegsmann, Rita Casadonte, Mark Kriegsmann, Tamas Juhasz, Sebastian Bardosi, Andrea Tamas, Balazs Daniel Fulop, Krisztina Kovacs, Zsuzsanna Nagy, Jason Sparks, Attila Miseta, Gabriel Mazzucchelli, Hitoshi Hashimoto, Attila Bardosi
Dysregulation of neuropeptides may play an important role in aging-induced impairments. Among them, pituitary adenylate cyclase activating polypeptide (PACAP) is a potent cytoprotective peptide that provides an endogenous control against a variety of tissue-damaging stimuli. We hypothesized that the progressive decline of PACAP throughout life, and the well-known general cytoprotective effects of PACAP lead to age-related pathophysiological changes in PACAP deficiency, supported by the increased vulnerability to various stressors of animals partially or totally lacking PACAP...
May 17, 2018: Journal of Pathology
https://www.readbyqxmd.com/read/29774511/emerging-lingo-cultural-inequality-in-infant-autopsy-in-quebec-canada
#19
Nathalie Auger, Marianne Bilodeau-Bertrand, André Costopoulos
We investigated trends in infant autopsy for Francophones and Anglophones in Quebec, Canada. Using death certificates, we extracted 8214 infant deaths between 1989 and 2013. We computed rates of non-autopsy by language, socioeconomic disadvantage, age at death, and period. Using Kitagawa's method, we decomposed non-autopsy rates over time for both language groups. Infant non-autopsy rates increased from 38.6 to 56.2 per 100 for Francophones, and from 41.2 to 57.2 per 100 for Anglophones, between 1989-1995 and 2008-2013...
May 17, 2018: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/29774174/outpatient-interventions-that-may-enhance-the-care-of-a-patient-with-co-existing-moyamoya-and-down-syndromes
#20
Anita Lwanga, Waldo Herrera, Katya Cruz Madrid, Antony Irungu
Moyamoya vasculopathy is a condition of chronic, progressive occlusion of the distal internal carotid arteries and the Circle of Willis. The resultant ischemia produces compensatory angiogenesis and the growth of a network of collateral blood vessels, which on angiography resemble a "puff of smoke" or "moyamoya" in Japanese. The objective of this case report is to describe the clinical course of a patient with Down and moyamoya syndromes and to enlighten clinicians about strategies that can be taken to enhance the care of similar patients...
March 16, 2018: Curēus
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