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https://www.readbyqxmd.com/read/28645196/antagonistic-regulation-of-cyclin-expression-by-the-bzip-transcription-factors-pcr1-and-atf1-during-g2-m-transition
#1
Sushobhana Bandyopadhyay, Protiti Maiti Ghosh, Sohini Basu, Madhurima Paul, Syed Benazir Alam, Elizabeth Das, Geetanjali Sundaram
The transcription factor Atf1 is known to promote cell survival during various stress conditions in Schizosaccharomyces pombe by activating the expression of appropriate genes. It can also activate transcription of other important genes responsible for cell cycle progression. An Atf1 dependent increase in the expression of cell division promoting genes will oppose activation of checkpoints necessary to ensure repairs and cell survival during stress. Hence selective inhibition of the cell cycle related functions of Atf1 would be indispensable for cellular survival during stress...
June 22, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/28645039/fundamental-causes-of-accelerated-declines-in-colorectal-cancer-mortality-modeling-multiple-ways-that-disadvantage-influences-mortality-risk
#2
Sean A P Clouston, Marcie S Rubin, David Chae, Jeremy Freese, Barbara Nemesure, Bruce G Link
BACKGROUND: Improvements in colorectal cancer (CRC) mortality reflect the distribution of effective preventions. Social inequalities often generate unequal diffusion of medical interventions, resulting in disparate outcomes while preventions are being disseminated throughout the population. This study used a novel method to examine whether Race (Black versus White) and SES influenced when rates of CRC mortality started to decline, and how rapidly they did so. METHOD: Mortality counts from 1968-2010 were derived from death certificates of U...
June 13, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28645018/take-over-performance-in-evasive-manoeuvres
#3
Riender Happee, Christian Gold, Jonas Radlmayr, Sebastian Hergeth, Klaus Bengler
We investigated after effects of automation in take-over scenarios in a high-end moving-base driving simulator. Drivers performed evasive manoeuvres encountering a blocked lane in highway driving. We compared the performance of drivers 1) during manual driving, 2) after automated driving with eyes on the road while performing the cognitively demanding n-back task, and 3) after automated driving with eyes off the road performing the visually demanding SuRT task. Both minimum time to collision (TTC) and minimum clearance towards the obstacle disclosed a substantial number of near miss events and are regarded as valuable surrogate safety metrics in evasive manoeuvres...
June 20, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28644870/effects-of-nicotine-on-corneal-wound-healing-following-acute-alkali-burn
#4
Jong Won Kim, Chae Woong Lim, Bumseok Kim
Epidemiological studies have indicated that smoking is a pivotal risk factor for the progression of several chronic diseases. Nicotine, the addictive component of cigarettes, has powerful pathophysiological properties in the body. Although the effects of cigarette smoking on corneal re-epithelialization have been studied, the effects of nicotine on corneal wound healing-related neovascularization and fibrosis have not been fully demonstrated. The aim of this study was to evaluate the effects of chronic administration of nicotine on corneal wound healing following acute insult induced by an alkali burn...
2017: PloS One
https://www.readbyqxmd.com/read/28644799/hybrid-cs-dmri-periodic-time-variant-subsampling-and-omnidirectional-total-variation-based-reconstruction
#5
Yipeng Liu, Shan Wu, Xiaolin Huang, Bing Chen, Ce Zhu
Compressive sensing (CS) has been used to accelerate dynamic magnetic resonance imaging (DMRI). Currently, the online CS-DMRI is faster, whereas the offline CS-DMRI provides higher accuracy for image reconstruction. To achieve good image reconstruction performance in terms of both speed and accuracy, we propose a hybrid CS-DMRI method using periodic timevariant subsampling for different frames. In each period, there is one reference frame that is sampled at a higher subsampling ratio. The two nearby reference frames with good reconstruction quality can be used to provide rough predictions of the other frames between them...
June 20, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28644755/a-contemporary-examination-of-first-and-second-permanent-molar-emergence
#6
B T Pahel, W F Vann, K Divaris, R G Rozier
The emergence of first permanent molars (FPMs) and second permanent molars (SPMs) is an important developmental milestone influencing caries risk and the timing of sealant placement. Emergence times have been shown to vary by sex and race/ethnicity, while recent reports suggest a positive association with adiposity. Amid the changing demographics of the US population and the rising rates of pediatric overweight/obesity, we sought to examine the association of body mass index (BMI) with FPM/SPM emergence in a representative sample of US children and adolescents...
June 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28644719/shaping-of-reach-to-grasp-kinematics-by-intentions-a-meta-analysis
#7
Ida Egmose, Simo Køppe
When we reach to grasp something, we need to take into account both the properties of the object we are grasping and the intention we have in mind. Previous research has found these constraints to be visible in the reach-to-grasp kinematics, but there is no consensus on which kinematic parameters are the most sensitive. To examine this, a systematic literature search and meta-analyses were performed. The search identified studies assessing how changes in either an object property or a prior intention affect reach-to-grasp kinematics in healthy participants...
June 23, 2017: Journal of Motor Behavior
https://www.readbyqxmd.com/read/28644435/p53-amyloid-formation-leading-to-its-loss-of-function-implications-in-cancer-pathogenesis
#8
Saikat Ghosh, Shimul Salot, Shinjinee Sengupta, Ambuja Navalkar, Dhiman Ghosh, Reeba Jacob, Subhadeep Das, Rakesh Kumar, Narendra Nath Jha, Shruti Sahay, Surabhi Mehra, Ganesh M Mohite, Santanu K Ghosh, Mamata Kombrabail, Guruswamy Krishnamoorthy, Pradip Chaudhari, Samir K Maji
The transcriptional regulator p53 has an essential role in tumor suppression. Almost 50% of human cancers are associated with the loss of p53 functions, where p53 often accumulates in the nucleus as well as in cytoplasm. Although it has been previously suggested that amyloid formation could be a cause of p53 loss-of-function in subset of tumors, the characterization of these amyloids and its structure-function relationship is not yet established. In the current study, we provide several evidences for the presence of p53 amyloid formation (in human and animal cancer tissues); along with its isolation from human cancer tissues and the biophysical characterization of these tissue-derived fibrils...
June 23, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/28644041/identifying-the-functional-groups-and-the-influence-of-synthetic-chelators-on-cd-availability-and-microbial-biomass-carbon-in-cd-contaminated-soil
#9
Muhammad Afzal Chhajro, Qingling Fu, Muhammad Shaaban, Muhammad Shahid Rizwan, Jun Zhu, Abdus Salam, Kashif Ali Kubar, Saqib Bashir, Hongqing Hu, Ghulam Murtaza Jamro
Synthetic chelators play an important role in boosting the microbial biomass carbon (MBC), dissolved organic carbon (DOC) and heavy metal solubility in a contaminated soil towards a sustainability of environment for agricultural crops. Castor was selected as a potential cadmium (Cd) accumulator in different levels of Cd (-Cd and +Cd) contamination with using three chelating agents, ethylenediamine tetraacetic acid (H4EDTA), nitriloacetic acid (H3 NTA) and NH4 citrate (ammonium citrate) were added to soil at rates of 10, 15 and 25 mmol in 5 kg of soil per pot...
June 23, 2017: International Journal of Phytoremediation
https://www.readbyqxmd.com/read/28643930/moving-towards-precision-orthodontics-an-evolving-paradigm-shift-in-the-planning-and-delivery-of-customized-orthodontic-therapy
#10
REVIEW
A H Jheon, S Oberoi, R C Solem, S Kapila
Advances in precision medicine portend similar progress in orthodontics and will be increasingly harnessed to achieve customized treatment approaches and enhance treatment efficiencies. Our goal is to provide a background on emerging advances in computer technologies and biomedicine and highlight their current and likely future applications to precision orthodontics. A review of orthodontically relevant technologies and advances in pertinent biological research was undertaken. Innovations in computer hardware and software, and 3D imaging technologies offer the ability for customized treatment and biomechanical planning that will be more fully realized within the next few decades...
June 2017: Orthodontics & Craniofacial Research
https://www.readbyqxmd.com/read/28643918/effect-of-cyclical-forces-on-orthodontic-tooth-movement-from%C3%A2-animals-to-humans
#11
REVIEW
F Uribe, E Dutra, T Chandhoke
Vibration as a non-invasive method is currently available for clinical use with the potential to accelerate the rate of tooth movement in orthodontics. The aim of this review was to evaluate the basic science and clinical literature on the effects of vibration on the axial and appendicular skeleton including the craniofacial bone. Vibration as a dynamic load consisting of high oscillatory forces of low magnitude has shown osteogenic and anti-catabolic effects on bone. These effects have been observed in the craniofacial skeleton including the alveolar bone as increases in sutural width and alveolar bone formation...
June 2017: Orthodontics & Craniofacial Research
https://www.readbyqxmd.com/read/28643913/effect-of-exogenous-retinoic-acid-on-tooth-movement-and-periodontium-healing-following-tooth-extraction-in-a-rat-model
#12
C Nishio, P Rompré, F Moldovan
OBJECTIVES: To evaluate the effect of isotretinoin on orthodontic tooth movement (OTM) and wound healing following exodontia. SETTING AND SAMPLE POPULATION: Sixteen 40-day-old male Wistar rats were divided into two groups: (a) OTM and (b) tooth extraction (TE) of the upper 1st molar and OTM. The experimental animals were treated with isotretinoin (7.5 mg/kg) and the control animals with oil solution for 37 days. MATERIALS AND METHODS: The OTM and bone volume were evaluated by the micro-CT and the periodontium healing was assessed by immunohistochemistry for VEGF-C, COX-2 and IL-1ß...
June 2017: Orthodontics & Craniofacial Research
https://www.readbyqxmd.com/read/28643751/quick-efficient-and-effective-patient-specific-intensity-modulated-radiation-therapy-quality-assurance-using-log-file-and-electronic-portal-imaging-device
#13
Rajesh Kumar, H I Amols, M Lovelock, S D Sharma, D Datta
AIM: The aim of work is to explore a quick, efficient, and effective patient-specific intensity-modulated radiation therapy (IMRT) quality assurance (QA). MATERIALS AND METHODS: Software tools were developed to extract and analyze the multi-leaf collimator (MLC) leaf positions (LPs) from electronic portal imaging device (EPID) images for Varian C-series machine and TrueBeam, to extract useful data from MLC log file of C-series linear accelerator (LINAC), to extract useful information from the trajectory log binary file of TrueBeam LINAC, to compare LPs derived from EPID images with log file/trajectory log data, and to analyze IMRT treatment files using the MATLAB programming language...
April 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28643574/stability-and-in-vitro-release-behaviour-of-encapsulated-omega-fatty-acid-rich-oils-in-lentil-protein-isolate-based-microcapsules
#14
C Chang, M T Nickerson
The objective of this study was to investigate the use of a lentil protein isolate-based microcapsule design as a platform for entrapping different types of omega fatty acid-rich oil (e.g. canola, fish and flaxseed oils) and to characterise differences in the physical properties (e.g. moisture content, water activity, colour, wettability, particle size, surface oil and entrapment efficiency), storage stability and in vitro release behaviour of the entrapped oils. All microcapsules displayed similar physical properties regardless of the core material...
June 23, 2017: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/28643250/genome-editing-in-mouse-zygotes-and-embryonic-stem-cells-by-introducing-sgrna-cas9-expressing-plasmids
#15
Taichi Noda, Asami Oji, Masahito Ikawa
In mammalian cells, genome editing with the single guide RNA (sgRNA)/Cas9 complex allows for high targeting efficiency within a relatively short time frame with the added benefits of being low cost and easy to design. sgRNA/Cas9-mediated editing in mouse zygotes has accelerated the analysis of gene functions and the generation of mouse models of human diseases. Despite the benefits, this method still suffers from several problems, such as mosaicism in the founder generation which complicates genotyping and phenotypical analyses, and the low efficiency of more complicated genome editing...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28643244/durvalumab-first-global-approval
#16
Yahiya Y Syed
Intravenous durvalumab (Imfinzi™; AstraZeneca) is a fully human monoclonal antibody that blocks programmed cell death ligand-1 binding to its receptors (PD-1 and CD80), resulting in enhanced T-cell responses against cancer cells. The US FDA has granted durvalumab accelerated approval for the treatment of patients with locally advanced or metastatic urothelial carcinoma who have disease progression during or following platinum-containing chemotherapy, or within 12 months of neoadjuvant or adjuvant platinum-containing chemotherapy...
June 22, 2017: Drugs
https://www.readbyqxmd.com/read/28642969/diverse-metabolic-effects-of-o-glcnacylation-in-the-pancreas-but-limited-effects-in-insulin-sensitive-organs-in-mice
#17
Shogo Ida, Katsutaro Morino, Osamu Sekine, Natsuko Ohashi, Shinji Kume, Tokuhiro Chano, Kanako Iwasaki, Norio Harada, Nobuya Inagaki, Satoshi Ugi, Hiroshi Maegawa
AIMS/HYPOTHESIS: O-GlcNAcylation is characterised by the addition of N-acetylglucosamine to various proteins by O-GlcNAc transferase (OGT) and serves in sensing intracellular nutrients by modulating various cellular processes. Although it has been speculated that O-GlcNAcylation is associated with glucose metabolism, its exact role in whole body glucose metabolism has not been fully elucidated. Here, we investigated whether loss of O-GlcNAcylation globally and in specific organs affected glucose metabolism in mammals under physiological conditions...
June 22, 2017: Diabetologia
https://www.readbyqxmd.com/read/28642835/differential-carbonyl-stress-expression-in-the-intervertebral-disc-between-singular-and-persistent-mechanical-injuries
#18
Itaru Hibino, Simon Tang
Low back pain is a significant public health problem worldwide. Intervertebral disc degeneration is most significant known risk factor for low back pain. Yet the mechanisms of degeneration remain relatively unknown. Carbonyl stress and oxidation have been implicated in cartilage and fibrocartilage degeneration. Here we investigate the role of oxidative stress and carbonyl production in the intervertebral disc after mechanical injury using an in vitro organ model of the mouse functional spine unit. We use a single-stab insult to model mild injury, and the three-stab insult to model severe trauma...
2017: Nagoya Gakuin Daigaku Ronshu Igaku Kenko Kagaku Supotsu Kagakuhen
https://www.readbyqxmd.com/read/28642670/ginkgo-biloba-improves-bone-formation-during-fracture-healing-an-experimental-study-in-rats
#19
Nizamettin Guzel, Emrah Sayit, Osman Aynaci, Servet Kerimoglu, Esin Yulug, Murat Topbas
OBJECTIVES: Ginkgo biloba extract (EGb 761) is a plant extract obtained from the leaves of the G. biloba tree. The aim of this study was to assess the histological and radiological effects of G. biloba extract on fracture healing in an experimental fracture model using rat femurs. METHODS: Forty-eight female Sprague-Dawley rats (weight: 195-252 g; age: 20 weeks) were used in the study. The rats were randomly divided into six groups (n=8). A transverse fracture was made in the middle of the right femur of each rat and fixed with a Kirschner wire...
May 2017: Acta Ortopedica Brasileira
https://www.readbyqxmd.com/read/28642473/predicting-effects-on-oxaliplatin-clearance-in-vitro-kinetic-and-clinical-studies-of-calcium-and-magnesium-mediated-oxaliplatin-degradation
#20
Catherine H Han, Prashannata Khwaounjoo, Andrew G Hill, Gordon M Miskelly, Mark J McKeage
This study evaluated the impact of calcium and magnesium on the in vitro degradation and in vivo clearance of oxaliplatin. Intact oxaliplatin and Pt(DACH)Cl2 were measured in incubation solutions by HPLC-UV. A clinical study determined changes in plasma concentrations of calcium and magnesium in cancer patients and their impact on oxaliplatin clearance. Kinetic analyses modelled oxaliplatin degradation reactions in vitro and contributions to oxaliplatin clearance in vivo. Calcium and magnesium accelerated oxaliplatin degradation to Pt(DACH)Cl2 in chloride-containing solutions in vitro...
June 22, 2017: Scientific Reports
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