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Christina Schumann, Michael Faust
BACKGROUND:  Diabetic ketoacidosis and the hyperosmolar hyperglycemic state are the most serious diabetic emergencies. Before the discovery of insulin in 1921 by Banting and Best the diagnosis of type 1 diabetes was fatal ending in diabetic ketoacidosis equivalent to a torturous death. Today, mortality from diabetic ketoacidosis is low at approximately 2 %. But each death from these two acute metabolic complications of diabetes is potentially avoidable by improved patient and healthcare professional education...
March 2018: Deutsche Medizinische Wochenschrift
Lucie Angel, Badiâa Bouazzaoui, Michel Isingrini, Séverine Fay, Laurence Taconnat, Sandrine Vanneste, Moïse Ledoux, Valérie Gissot, Caroline Hommet, Fréderic Andersson, Laurent Barantin, Jean-Philippe Cottier, Jérémy Pasco, Thomas Desmidt, Frédéric Patat, Vincent Camus, Jean-Pierre Remenieras
Aging is characterized by a cognitive decline of fluid abilities and is also associated with electrophysiological changes. The vascular hypothesis proposes that brain is sensitive to vascular dysfunction which may accelerate age-related brain modifications and thus explain age-related neurocognitive decline. To test this hypothesis, cognitive performance was measured in 39 healthy participants from 20 to 80 years, using tests assessing inhibition, fluid intelligence, attention and crystallized abilities. Brain functioning associated with attentional abilities was assessed by measuring the P3b ERP component elicited through an auditory oddball paradigm...
March 12, 2018: Brain and Cognition
Yan-Mei Lei, Bai-Qi Xiao, Wen-Bin Liang, Ya-Qin Chai, Ruo Yuan, Ying Zhuo
It is well known that the conventional electrochemiluminescence (ECL) biosensor rely on the heterogeneous assay formats that involves the immobilization of biorecognition probe on the electrode surface before signal collection, which inevitably cause the efficiency of bio-recognition reactions to be limited owing to the existence of local steric hindrance. Herein, a robust, magnetic, and self-accelerated ECL nanosensor based on the multifunctionalized cobalt ferrite magnetite nanoparticles (CoFe2 O4 MNPs) was firstly designed for copper ion (Cu2+ ) detection in quasi-homogeneous system...
March 7, 2018: Biosensors & Bioelectronics
Wei Qian, Xiaodong Hu, Weifeng He, Rixing Zhan, Menglong Liu, Daijun Zhou, Yong Huang, Xiaohong Hu, Zhanhua Wang, Guoxia Fei, Jun Wu, Malcolm Xing, Hesheng Xia, Gaoxing Luo
Toward fabricating a novel multifunctional wound dressing material, we incorporated a series of contents of reduced graphene oxide (rGO) sheets into polydimethylsiloxane (PDMS) matrix to prepare the rGO-PDMS composite membrane and be used for wound dressing. The pore structure, dispersion of rGO, physical properties, water vapor transmission rate (WVTR), cytotoxicity and antibacterial activity were studied. Finally, the effect of the rGO-PDMS composite membrane on wound healing was investigated on a murine full-thickness skin wound model...
March 12, 2018: Colloids and Surfaces. B, Biointerfaces
Alejandro Amor-Coarasa, James Kelly, Shashikanth Ponnala, Yogindra Vedvyas, Anastasia Nikolopoulou, Clarence Williams, Moonsoo M Jin, J David Warren, John W Babich
INTRODUCTION: CXCR4 specific [18 F]-labeled positron emission tomography (PET) imaging agents are needed which would enable general distribution of the radiotracer for clinical investigation. We sought to synthesize, radiolabel and evaluate [18 F]RPS-544, a novel non-peptide CXCR4 antagonist as a CXCR4 specific probe. We compared [18 F]RPS-544 with the previously published [18 F]-3 ([18 F]RPS-510 in this paper) in a bi-lateral tumor model of differential CXCR4 expression for its ability to selectively target CXCR4 expression...
January 31, 2018: Nuclear Medicine and Biology
Emily Wonder, Lorena Simón-Gracia, Pablo Scodeller, Ramsey N Majzoub, Venkata Ramana Kotamraju, Kai K Ewert, Tambet Teesalu, Cyrus R Safinya
Cationic liposome-nucleic acid (CL-NA) complexes, which form spontaneously, are a highly modular gene delivery system. These complexes can be sterically stabilized via PEGylation [PEG: poly (ethylene glycol)] into nanoparticles (NPs) and targeted to specific tissues and cell types via the conjugation of an affinity ligand. However, there are currently no guidelines on how to effectively navigate the large space of compositional parameters that modulate the specific and nonspecific binding interactions of peptide-targeted NPs with cells...
March 2, 2018: Biomaterials
Takuya Wakamatsu, Suguru Yamamoto, Toru Ito, Yoko Sato, Koji Matsuo, Yoshimitsu Takahashi, Yoshikatsu Kaneko, Shin Goto, Junichiro James Kazama, Fumitake Gejyo, Ichiei Narita
In chronic kidney disease (CKD) patients, accumulation of uremic toxins is associated with cardiovascular risk and mortality. One of the hallmarks of kidney disease-related cardiovascular disease is intravascular macrophage inflammation, but the mechanism of the reaction with these toxins is not completely understood. Macrophages differentiated from THP-1 cells were exposed to indoxyl sulfate (IS), a representative uremic toxin, and changes in inflammatory cytokine production and intracellular signaling molecules including interleukin (IL)-1, aryl hydrocarbon receptor (AhR), nuclear factor (NF)-κ, and mitogen-activated protein kinase (MAPK) cascades as well as the NLRP3 inflammasome were quantified by real-time PCR, Western blot analysis, and enzyme-linked immunosorbent assay...
March 15, 2018: Toxins
Benjamin Stauch, Vadim Cherezov
G protein-coupled receptors (GPCRs) represent a large superfamily of membrane proteins that mediate cell signaling and regulate a variety of physiological processes in the human body. Structure-function studies of this superfamily were enabled a decade ago by multiple breakthroughs in technology that included receptor stabilization, crystallization in a membrane environment, and microcrystallography. The recent emergence of X-ray free-electron lasers (XFELs) has further accelerated structural studies of GPCRs and other challenging proteins by overcoming radiation damage and providing access to high-resolution structures and dynamics using micrometer-sized crystals...
March 15, 2018: Annual Review of Biophysics
Miguel A Marioni, Marcos Penedo, Mirko Baćani, Johannes Schwenk, Hans Josef Hug
Mallinson's idea that some spin textures in planar magnetic structures could produce an enhancement of the magnetic flux on one side of the plane at the expense of the other gave rise to permanent magnet configurations known as Halbach magnet arrays. Applications range from wiggler magnets in particle accelerators and free electron lasers, to motors, to magnetic levitation trains, but exploiting Halbach arrays in micro- or nanoscale spintronics devices requires solving the problem of fabrication and field metrology below 100 μm size...
March 15, 2018: Nano Letters
Hyeon Yong Lee
BACKGROUND: The development of an alternative medicine to treat atopic dermatitis (AD) from natural sources is necessary. AIMS: To improve skin barrier dysfunction by enhancing the differentiation of human keratinocytes with the fermented Scutellaria baicalensis. METHODS: Scutellaria baicalensis was fermented with Lactobacillus plantarum and extracted with 70% ethanol (FE). Antioxidant activities and the regulation of the gene expression related to keratinocyte differentiation were measured as well as its proliferation...
March 15, 2018: Journal of Cosmetic Dermatology
Atul Rungta, Carl Schissler, Nicholas Rewkowski, Ravish Mehra, Dinesh Manocha
We present a novel method to generate plausible diffraction effects for interactive sound propagation in dynamic scenes. Our approach precomputes a diffraction kernel for each dynamic object in the scene and combines them with interactive ray tracing algorithms at runtime. A diffraction kernel encapsulates the sound interaction behavior of individual objects in the free field and we present a new source placement algorithm to significantly accelerate the precomputation. Our overall propagation algorithm can handle highly-tessellated or smooth objects undergoing rigid motion...
April 2018: IEEE Transactions on Visualization and Computer Graphics
Janaina de Freitas Nascimento, Steven Kelly, Jack Sunter, Mark Carrington
Selective transcription of individual protein coding genes does not occur in trypanosomes and the cellular copy number of each mRNA must be determined post-transcriptionally. Here, we provide evidence that codon choice directs the levels of constitutively expressed mRNAs. First, a novel codon usage metric, the gene expression codon adaptation index (geCAI), was developed that maximised the relationship between codon choice and the measured abundance for a transcriptome. Second, geCAI predictions of mRNA levels were tested using differently coded GFP transgenes and were successful over a 25-fold range, similar to the variation in endogenous mRNAs...
March 15, 2018: ELife
Lieselot Decroix, Cajsa Tonoli, Elodie Lespagnol, Constantino Balestra, Amandine Descat, Marie Jose Drittij-Reijnders, Jamie R Blackwell, Wilhelm Stahl, Andrew M Jones, Antje R Weseler, Aalt Bast, Romain Meeusen, Elsa Heyman
INTRODUCTION: During exercise in hypoxia, O2 delivery to brain and muscle is compromised and oxidative stress is elicited. Cocoa flavanols (CF) have antioxidant capacities and can increase blood flow by stimulating endothelial function. We aimed to examine the effects of 7-day CF intake on oxidative stress, nitric oxide production and tissue oxygenation in response to exercise in hypoxia (14.3% O2 ). METHODS: In a randomized, double blind, cross-over study, 14 well-trained male cyclists completed 4 trials: exercise in normoxia or hypoxia, after 7-day CF or placebo intake...
March 15, 2018: Journal of Applied Physiology
Yasmine Mosleh, Martin Cajka, Bart Depreitere, Jos Vander Sloten, Jan Ivens
Oblique impact is the most common accident situation that occupants in traffic accidents or athletes in professional sports experience. During oblique impact, the human head is subjected to a combination of linear and rotational accelerations. Rotational movement is known to be responsible for traumatic brain injuries. In this article, composite foam with a column/matrix composite configuration is proposed for head protection applications to replace single-layer uniform foam, to better attenuate rotational movement of the head during oblique impacts...
March 1, 2018: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
Esther Morencos, Blanca Romero-Moraleda, Carlo Castagna, David Casamichana
PURPOSE: The aim of this study was to examine the influence of match period on the movement patterns of hockey players according to their playing position under the introduction of quarters. METHODS: Sixteen sub-elite level Spanish National League male hockey players participated in the study (age: 25.5 ± 2.9 years; body mass: 74.6 ± 5.5 kg). Global Positioning Systems (GPS) devices were used to monitor players running performance during 17 competitive matches (113 match-play profiles)...
March 15, 2018: International Journal of Sports Physiology and Performance
M G Aartsen, M Ackermann, J Adams, J A Aguilar, M Ahlers, M Ahrens, I Al Samarai, D Altmann, K Andeen, T Anderson, I Ansseau, G Anton, C Argüelles, J Auffenberg, S Axani, H Bagherpour, X Bai, J P Barron, S W Barwick, V Baum, R Bay, J J Beatty, J Becker Tjus, K-H Becker, S BenZvi, D Berley, E Bernardini, D Z Besson, G Binder, D Bindig, E Blaufuss, S Blot, C Bohm, M Börner, F Bos, D Bose, S Böser, O Botner, J Bourbeau, F Bradascio, J Braun, L Brayeur, M Brenzke, H-P Bretz, S Bron, J Brostean-Kaiser, A Burgman, T Carver, J Casey, M Casier, E Cheung, D Chirkin, A Christov, K Clark, L Classen, S Coenders, G H Collin, J M Conrad, D F Cowen, R Cross, M Day, J P A M de André, C De Clercq, J J DeLaunay, H Dembinski, S De Ridder, P Desiati, K D de Vries, G de Wasseige, M de With, T DeYoung, J C Díaz-Vélez, V di Lorenzo, H Dujmovic, J P Dumm, M Dunkman, B Eberhardt, T Ehrhardt, B Eichmann, P Eller, P A Evenson, S Fahey, A R Fazely, J Felde, K Filimonov, C Finley, S Flis, A Franckowiak, E Friedman, T Fuchs, T K Gaisser, J Gallagher, L Gerhardt, K Ghorbani, W Giang, T Glauch, T Glüsenkamp, A Goldschmidt, J G Gonzalez, D Grant, Z Griffith, C Haack, A Hallgren, F Halzen, K Hanson, D Hebecker, D Heereman, K Helbing, R Hellauer, S Hickford, J Hignight, G C Hill, K D Hoffman, R Hoffmann, B Hokanson-Fasig, K Hoshina, F Huang, M Huber, K Hultqvist, M Hünnefeld, S In, A Ishihara, E Jacobi, G S Japaridze, M Jeong, K Jero, B J P Jones, P Kalaczynski, W Kang, A Kappes, T Karg, A Karle, U Katz, M Kauer, A Keivani, J L Kelley, A Kheirandish, J Kim, M Kim, T Kintscher, J Kiryluk, T Kittler, S R Klein, G Kohnen, R Koirala, H Kolanoski, L Köpke, C Kopper, S Kopper, J P Koschinsky, D J Koskinen, M Kowalski, K Krings, M Kroll, G Krückl, J Kunnen, S Kunwar, N Kurahashi, T Kuwabara, A Kyriacou, M Labare, J L Lanfranchi, M J Larson, F Lauber, D Lennarz, M Lesiak-Bzdak, M Leuermann, Q R Liu, L Lu, J Lünemann, W Luszczak, J Madsen, G Maggi, K B M Mahn, S Mancina, R Maruyama, K Mase, R Maunu, F McNally, K Meagher, M Medici, M Meier, T Menne, G Merino, T Meures, S Miarecki, J Micallef, G Momenté, T Montaruli, R W Moore, M Moulai, R Nahnhauer, P Nakarmi, U Naumann, G Neer, H Niederhausen, S C Nowicki, D R Nygren, A Obertacke Pollmann, A Olivas, A O'Murchadha, T Palczewski, H Pandya, D V Pankova, P Peiffer, J A Pepper, C Pérez de Los Heros, D Pieloth, E Pinat, M Plum, P B Price, G T Przybylski, C Raab, L Rädel, M Rameez, K Rawlins, I C Rea, R Reimann, B Relethford, M Relich, E Resconi, W Rhode, M Richman, S Robertson, M Rongen, C Rott, T Ruhe, D Ryckbosch, D Rysewyk, T Sälzer, S E Sanchez Herrera, A Sandrock, J Sandroos, S Sarkar, S Sarkar, K Satalecka, P Schlunder, T Schmidt, A Schneider, S Schoenen, S Schöneberg, L Schumacher, D Seckel, S Seunarine, J Soedingrekso, D Soldin, M Song, G M Spiczak, C Spiering, J Stachurska, M Stamatikos, T Stanev, A Stasik, J Stettner, A Steuer, T Stezelberger, R G Stokstad, A Stößl, N L Strotjohann, G W Sullivan, M Sutherland, I Taboada, J Tatar, F Tenholt, S Ter-Antonyan, A Terliuk, G Tešić, S Tilav, P A Toale, M N Tobin, S Toscano, D Tosi, M Tselengidou, C F Tung, A Turcati, C F Turley, B Ty, E Unger, M Usner, J Vandenbroucke, W Van Driessche, N van Eijndhoven, S Vanheule, J van Santen, M Vehring, E Vogel, M Vraeghe, C Walck, A Wallace, M Wallraff, F D Wandler, N Wandkowsky, A Waza, C Weaver, M J Weiss, C Wendt, J Werthebach, S Westerhoff, B J Whelan, K Wiebe, C H Wiebusch, L Wille, D R Williams, L Wills, M Wolf, J Wood, T R Wood, E Woolsey, K Woschnagg, D L Xu, X W Xu, Y Xu, J P Yanez, G Yodh, S Yoshida, T Yuan, M Zoll
We present a measurement of the atmospheric neutrino oscillation parameters using three years of data from the IceCube Neutrino Observatory. The DeepCore infill array in the center of IceCube enables the detection and reconstruction of neutrinos produced by the interaction of cosmic rays in Earth's atmosphere at energies as low as ∼5  GeV. That energy threshold permits measurements of muon neutrino disappearance, over a range of baselines up to the diameter of the Earth, probing the same range of L/E_{ν} as long-baseline experiments but with substantially higher-energy neutrinos...
February 16, 2018: Physical Review Letters
J H Bin, M Yeung, Z Gong, H Y Wang, C Kreuzer, M L Zhou, M J V Streeter, P S Foster, S Cousens, B Dromey, J Meyer-Ter-Vehn, M Zepf, J Schreiber
We report on the experimental studies of laser driven ion acceleration from a double-layer target where a near-critical density target with a few-micron thickness is coated in front of a nanometer-thin diamondlike carbon foil. A significant enhancement of proton maximum energies from 12 to ∼30  MeV is observed when a relativistic laser pulse impinges on the double-layer target under linear polarization. We attributed the enhanced acceleration to superponderomotive electrons that were simultaneously measured in the experiments with energies far beyond the free-electron ponderomotive limit...
February 16, 2018: Physical Review Letters
Z H Zhong, R X Tang, M Zhou, X H Deng, Y Pang, W R Paterson, B L Giles, J L Burch, R B Tobert, R E Ergun, Y V Khotyaintsev, P-A Lindquist
Secondary flux ropes are suggested to play important roles in energy dissipation and particle acceleration during magnetic reconnection. However, their generation mechanism is not fully understood. In this Letter, we present the first direct evidence that a secondary flux rope was generated due to the evolution of an electron vortex, which was driven by the electron Kelvin-Helmholtz instability in an ion diffusion region as observed by the Magnetospheric Multiscale mission. The subion scale (less than the ion inertial length) flux rope was embedded within the electron vortex, which contained a secondary electron diffusion region at the trailing edge of the flux rope...
February 16, 2018: Physical Review Letters
Hiroki Yokoi, Satoru Hiroto, Hiroshi Shinokubo
The reversible formation of σ-bonds between organic radicals has been widely investigated. However, reports on the formation of σ-dimers from delocalized π-radical cations are scarce. Herein, we report the reversible σ-dimerization behavior of a bowl-shaped π-radical cation generated from a nitrogen-embedded buckybowl, both in the crystalline state and in solution. The detailed structure of the σ-dimer in the crystalline state was determined by a single-crystal X-ray diffraction analysis. The monomeric radical cation exists predominantly in solution at room temperature, while dimerization of the radical cations occurs through carbon-carbon σ-bond formation upon reducing the temperature...
March 15, 2018: Journal of the American Chemical Society
Nathan Cho, Panagiotis Tsiamas, Esteban Velarde, Erik Tryggestad, Robert Jacques, Ross Berbeco, Todd McNutt, Peter Kazanzides, John Wong
PURPOSE: The Small Animal Radiation Research Platform (SARRP) has been developed for conformal micro irradiation with on-board cone-beam CT (CBCT) guidance. The graphics processing unit (GPU)-accelerated Superposition-Convolution (SC) method for dose computation has been integrated into the treatment planning system (TPS) for SARRP. This paper describes the validation of the SC method for the kilovoltage energy by comparing with EBT2 film measurements and Monte Carlo (MC) simulations...
March 15, 2018: Medical Physics
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