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https://www.readbyqxmd.com/read/28814049/wearable-sensing-for-rehabilitation-after-stroke-bimanual-jerk-asymmetry-encodes-unique-information-about-the-variability-of-upper-extremity-recovery
#1
Diogo S de Lucena, Oliver Stoller, Justin B Rowe, Vicky Chan, David J Reinkensmeyer
Wearable sensing is a new tool for quantifying upper extremity (UE) rehabilitation after stroke. However, it is unclear whether it provides information beyond what is available through standard clinical assessments. To investigate this question, people with a chronic stroke (n=9) wore accelerometers on both wrists for 9 hours on a single day during their daily activities. We used principal components analysis (PCA) to characterize how novel kinematic measures of jerk and acceleration asymmetry, along with conventional measures of limb use asymmetry and clinical function, explained the behavioral variance of UE recovery across participants...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813957/an-instrumented-object-for-studying-human-grasping
#2
R A Romeo, F Cordelia, A Davalli, R Sacchetti, E Guglielmelli, L Zollo
This paper proposes the use of an instrumented object for the study of the human grasping strategies. The proposed object is able to measure the grasping forces by means of three Force Sensitive Resistor (FSR) sensors and triaxial acceleration through an accelerometer. The object orientation angles (roll and pitch) can be estimated from the accelerometer output in quasi-static condition, whereas slippage events can be detected through the Power Spectrum Density (PSD) computation of the acceleration on at least one of the three axes...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813881/simulation-of-variable-impedance-as-an-intervention-for-upper-extremity-motor-exploration
#3
Felix C Huang
Current methods in robot-assisted therapy are limited in providing predictions of the effectiveness of interventions. Our approach focuses on how robotic interaction can impact the distribution of movements expressed in the arm. Using data from a previous study with stroke survivors (n=10), we performed simulations to examine how changes in hand endpoint impedance would alter exploratory motion. We present methods for designing a custom training intervention, by relating the desired change in acceleration covariance in planar motion with a corresponding change in inertia matrix...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813820/design-of-an-exoskeleton-ankle-robot-for-robot-assisted-gait-training-of-stroke-patients
#4
Ling-Fung Yeung, Corinna Ockenfeld, Man-Kit Pang, Hon-Wah Wai, Oi-Yan Soo, Sheung-Wai Li, Kai-Yu Tong
Lower Limb Exoskeleton robot that can facilitate stair walking is a big challenge, most systems could only provide level ground walking. In this study, a lightweight (0.5kg at ankle, 0.5kg at waist for control box) and autonomous exoskeleton Ankle Robot was proposed to provide power assistance for gait training of chronic stroke patients and it can facilitate three walking conditions in real-time: (1) level walking, (2) stair ascending, and (3) stair descending. Chronic stroke patients (n=3) with drop foot gait deficit and moderate motor impairment were recruited to evaluate the system under different walking conditions (Functional Ambulatory Category: FAC=4...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813704/p38-kinase-sgk1-and-nf-%C3%AE%C2%BAb-dependent-up-regulation-of-na-ca2-exchanger-expression-and-activity-following-tgf%C3%A3-1-treatment-of-megakaryocytes
#5
Tamer Al-Maghout, Lisann Pelzl, Itishri Sahu, Basma Sukkar, Zohreh Hosseinzadeh, Ravi Gutti, Stefan Laufer, Jakob Voelkl, Burkert Pieske, Meinrad Gawaz, Florian Lang
BACKGROUND: TGFβ1, a decisive regulator of megakaryocyte maturation and platelet formation, has previously been shown to up-regulate both, store operated Ca2+ entry (SOCE) and Ca2+ extrusion by Na+/Ca2+ exchange. The growth factor thus augments the increase of cytosolic Ca2+ activity ([Ca2+]i) following release of Ca2+ from intracellular stores and accelerates the subsequent decline of [Ca2+]i. The effect on SOCE is dependent on a signaling cascade including p38 kinase, serum & glucocorticoid inducible kinase SGK1, and nuclear factor NFκB...
August 15, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28813547/an-experimental-and-numerical-study-of-hybrid-iii-dummy-response-to-simulated-underbody-blast-impacts
#6
Karthik Somasundaram, Anil Kalra, Don Sherman, Paul Begeman, King H Yang, John M Cavanaugh
Anthropometric test devices (ATDs) such as Hybrid III dummy have been widely used in automotive crash tests to evaluate the risks of injury at different body regions. In recent years, researchers have started using automotive ATDs to study the high-speed vertical loading response caused by underbelly blast (UBB) impacts. This study analyzed the Hybrid III dummy responses to short-duration large magnitude vertical acceleration in a laboratory setup. Two unique test conditions were investigated using a horizontal sled system to simulate the UBB loading conditions...
August 16, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/28813522/surveillance-in-easy-to-access-population-subgroups-as-a-tool-for-evaluating-malaria-control-progress-a-systematic-review
#7
Sanie S S Sesay, Emanuele Giorgi, Peter J Diggle, David Schellenberg, David G Lalloo, Dianne J Terlouw
BACKGROUND: The need for surveillance systems generating targeted, data-driven, responsive control efforts to accelerate and sustain malaria transmission reduction has been emphasized by programme managers, policy makers and scientists. Surveillance using easy-to-access population subgroups (EAGs) may result in considerable cost saving compared to household surveys as the identification and selection of individuals to be surveyed is simplified, fewer personnel are needed, and logistics are simpler...
2017: PloS One
https://www.readbyqxmd.com/read/28813510/construction-of-novel-pjrd215-derived-plasmids-using-chloramphenicol-acetyltransferase-cat-gene-as-a-selection-marker-for-acidithiobacillus-caldus
#8
Rui Wang, Chunmao Lin, Jianqiang Lin, Xin Pang, Xiangmei Liu, Chengjia Zhang, Jianqun Lin, Linxu Chen
BACKGROUND: Acidithiobacillus caldus, a Gram-negative, chemolithotrophic sulfur-oxidizing bacterium, is widely applied in bioleaching. The absence of an ideal selection marker has become a major obstacle to achieve high efficiency of the gene transfer system for A. caldus. Plasmid pJRD215, widely used in Acidithiobacillus spp., has severe drawbacks in molecular manipulations and potential biosafety issues due to its mobility. Therefore, finding a new selection marker and constructing new plasmids have become an urgent and fundamental work for A...
2017: PloS One
https://www.readbyqxmd.com/read/28813500/telomere-biology-and-telomerase-mutations-in-cirrhotic-patients-with-hepatocellular-carcinoma
#9
Flávia S Donaires, Natália F Scatena, Raquel M Alves-Paiva, Joshua D Podlevsky, Dhenugen Logeswaran, Barbara A Santana, Andreza C Teixeira, Julian J-L Chen, Rodrigo T Calado, Ana L C Martinelli
Telomeres are repetitive DNA sequences at linear chromosome termini, protecting chromosomes against end-to-end fusion and damage, providing chromosomal stability. Telomeres shorten with mitotic cellular division, but are maintained in cells with high proliferative capacity by telomerase. Loss-of-function mutations in telomere-maintenance genes are genetic risk factors for cirrhosis development in humans and murine models. Telomerase deficiency provokes accelerated telomere shortening and dysfunction, facilitating genomic instability and oncogenesis...
2017: PloS One
https://www.readbyqxmd.com/read/28813482/cysteine-rich-protein-2-accelerates-actin-filament-cluster-formation
#10
Takanori Kihara, Yasunobu Sugimoto, Satoko Shinohara, Shunpei Takaoka, Jun Miyake
Filamentous actin (F-actin) forms many types of structures and dynamically regulates cell morphology and movement, and plays a mechanosensory role for extracellular stimuli. In this study, we determined that the smooth muscle-related transcription factor, cysteine-rich protein 2 (CRP2), regulates the supramolecular networks of F-actin. The structures of CRP2 and F-actin in solution were analyzed by small-angle X-ray solution scattering (SAXS). The general shape of CRP2 was partially unfolded and relatively ellipsoidal in structure, and the apparent cross sectional radius of gyration (Rc) was about 15...
2017: PloS One
https://www.readbyqxmd.com/read/28813421/stromal-r-spondin-orchestrates-gastric-epithelial-stem-cells-and-gland-homeostasis
#11
Michael Sigal, Catriona Y Logan, Marta Kapalczynska, Hans-Joachim Mollenkopf, Hilmar Berger, Bertram Wiedenmann, Roeland Nusse, Manuel R Amieva, Thomas F Meyer
The constant regeneration of stomach epithelium is driven by long-lived stem cells, but the mechanism that regulates their turnover is not well understood. We have recently found that the gastric pathogen Helicobacter pylori can activate gastric stem cells and increase epithelial turnover, while Wnt signalling is known to be important for stem cell identity and epithelial regeneration in several tissues. Here we find that antral Wnt signalling, marked by the classic Wnt target gene Axin2, is limited to the base and lower isthmus of gastric glands, where the stem cells reside...
August 16, 2017: Nature
https://www.readbyqxmd.com/read/28813248/early-stress-parental-motivation-and-reproductive-decision-making-applications-of-life-history-theory-to-parental-behavior
#12
REVIEW
Tomás Cabeza de Baca, Bruce J Ellis
This review focuses on the impact of parental behavior on child development, as interpreted from an evolutionary-developmental perspective. We employ psychosocial acceleration theory to reinterpret the effects of variation in parental investment and involvement on child development, arguing that these effects have been structured by natural selection to match the developing child to current and expected future environments. Over time, an individual's development, physiology, and behavior are organized in a coordinated manner (as instantiated in 'life history strategies') that facilitates survival and reproductive success under different conditions...
June 2017: Current Opinion in Psychology
https://www.readbyqxmd.com/read/28813155/research-on-controllable-degradation-of-novel-sulfonylurea-herbicides-in-acidic-and-alkaline-soils
#13
Shaa Zhou, Xue-Wen Hua, Wei Wei, Yu-Cheng Gu, Xiaoqing Liu, Jinghuo Chen, Minggui Chen, Yong-Tao Xie, Sha Zhou, Xiang-De Meng, Yan Zhang, Yong-Hong Li, Baolei Wang, Haibin Song, Zheng-Ming Li
The degradation issue of sulfonylurea (SU) has become one of the biggest challenges that hamper the development and application of this class of herbicides, especially in alkaline soils of Northern China. On the basis of previous discovery that some substituents on the 5th position of the benzene ring in Chlorsulfuron could hasten its degradation rate apparently in acidic soil, this work on Metsulfuron-methyl showed more convincing results. Two novel compounds (I-1 and I-2) were designed and synthesized, at the same time, they still retained potent herbicidal activity against both tested dicotyledon and monocotyledon...
August 16, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28813138/quantifying-lake-water-quality-evolution-coupled-geochemistry-hydrodynamics-and-aquatic-ecology-in-an-acidic-pit-lake
#14
S Ursula Salmon, Matthew R Hipsey, Geoffrey W Wake, Gregory N Ivey, Carolyn E Oldham
Assessment of water quality evolution in the thousands of existing and future mine pit lakes worldwide requires new numerical tools that integrate geochemical, hydrological, and biological processes. A coupled model was used to test alternative hypothesized controls on water quality in a pit lake over ∼8 years. The evolution of pH, Al, and Fe were closely linked; field observations were reproduced with generic solubility equilibrium controls on Fe(III) and Al and a commonly reported acceleration of the abiotic Fe(II) oxidation rate by 2-3 orders of magnitude...
August 16, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28813061/indole-synthesis-by-palladium-catalyzed-tandem-allylic-isomerization-furan-diels-alder-reaction
#15
Jie Xu, Peter Wipf
A Pd(0)-catalyzed elimination of an allylic acetate generates a π-allyl complex that is postulated to initiate a novel intramolecular Diels-Alder cycloaddition to a tethered furan (IMDAF). Under the reaction conditions, this convergent, microwave-accelerated cascade process provides substituted indoles in moderate to good yields after Pd-hydride elimination, aromatization by dehydration, and in situ N-Boc cleavage.
August 16, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28812622/species-rich-networks-and-eco-evolutionary-synthesis-at-the-metacommunity-level
#16
Hirokazu Toju, Masato Yamamichi, Paulo R Guimarães, Jens M Olesen, Akihiko Mougi, Takehito Yoshida, John N Thompson
Understanding how ecological and evolutionary processes interdependently structure biosphere dynamics is a major challenge in the era of worldwide ecosystem degradation. However, our knowledge of 'eco-evolutionary feedbacks' depends largely on findings from simple systems representing limited spatial scales and involving few species. Here we review recent conceptual developments for the understanding of multispecies coevolutionary processes and then discuss how new lines of concepts and methods will accelerate the integration of ecology and evolutionary biology...
January 24, 2017: Nature ecology & evolution
https://www.readbyqxmd.com/read/28812580/lactate-dehydrogenase-activity-drives-hair-follicle-stem-cell-activation
#17
Aimee Flores, John Schell, Abigail S Krall, David Jelinek, Matilde Miranda, Melina Grigorian, Daniel Braas, Andrew C White, Jessica L Zhou, Nicholas A Graham, Thomas Graeber, Pankaj Seth, Denis Evseenko, Hilary A Coller, Jared Rutter, Heather R Christofk, William E Lowry
Although normally dormant, hair follicle stem cells (HFSCs) quickly become activated to divide during a new hair cycle. The quiescence of HFSCs is known to be regulated by a number of intrinsic and extrinsic mechanisms. Here we provide several lines of evidence to demonstrate that HFSCs utilize glycolytic metabolism and produce significantly more lactate than other cells in the epidermis. Furthermore, lactate generation appears to be critical for the activation of HFSCs as deletion of lactate dehydrogenase (Ldha) prevented their activation...
August 14, 2017: Nature Cell Biology
https://www.readbyqxmd.com/read/28812563/multicopy-plasmids-potentiate-the-evolution-of-antibiotic-resistance-in-bacteria
#18
Alvaro San Millan, Jose Antonio Escudero, Danna R Gifford, Didier Mazel, R Craig MacLean
Plasmids are thought to play a key role in bacterial evolution by acting as vehicles for horizontal gene transfer, but the role of plasmids as catalysts of gene evolution remains unexplored. We challenged populations of Escherichia coli carrying the blaTEM-1 β-lactamase gene on either the chromosome or a multicopy plasmid (19 copies per cell) with increasing concentrations of ceftazidime. The plasmid accelerated resistance evolution by increasing the rate of appearance of novel TEM-1 mutations, thereby conferring resistance to ceftazidime, and then by amplifying the effect of TEM-1 mutations due to the increased gene dosage...
November 7, 2016: Nature ecology & evolution
https://www.readbyqxmd.com/read/28812358/bioinspired-active-stealth-magneto-nanomicelles-for-theranostics-combining-efficient-mri-and-enhanced-drug-delivery
#19
Kai-Long Zhang, Jie Zhou, Hong Zhou, Ying Wu, Rui Liu, Li-Li Wang, Wei-Wen Lin, Guoming Huang, Huang-Hao Yang
The mononuclear phagocyte system (MPS), with key roles in recognition and clearance of foreign particles, is a major constraint to nanoparticle-based delivery systems. The desire to improve the delivery efficiency has prompted the search for stealthy long-circulating nanoplatforms. Herein, we design an antiphagocytic delivery system with "active" stealth behavior for cancer theranostics combining efficient MRI and enhanced drug delivery. We modify self-peptide, a synthetic peptide for active immunomodulation, to biodegradable poly (lactide-glycolide)-poly (ethylene glycol) (PLGA-PEG), then utilize the self-assembly properties of PLGA-PEG to form nanomicelles that encapsulating iron oxide (IO) nanoparticles and anticancer drug paclitaxel (PTX)...
August 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28812329/acid-labile-acyclic-cucurbit-n-uril-molecular-containers-for-controlled-release
#20
Dake Mao, Yajun Liang, Yamin Liu, Xianhao Zhou, Jiaqi Ma, Jia Liu, Biao Jiang, Da Ma
Stimuli responsive molecular containers are of great importance for controlled drug delivery and other biomedical applications. Here, we report a new type of acid labile acyclic cucurbit[n]uril (CB[n]) molecular containers, which can degrade and release the encapsulated cargo with accelerated rates under mildly acidic conditions (pH 5.5-6.5). These containers retain the excellent recognition property of CB[n] type hosts. Cell culture study demonstrated that the cellular uptake of cargos could be fine-tuned by complexation with different containers...
August 15, 2017: Angewandte Chemie
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