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https://www.readbyqxmd.com/read/29051913/patients-with-dementia-are-easy-victims-to-predators
#1
R C Hamdy, J V Lewis, R Copeland, A Depelteau, A Kinser, T Kendall-Wilson, K Whalen
Patients with dementia, especially Alzheimer's disease and particularly those in early stages, are susceptible to become victims of predators: Their agnosia (see Case 1) prevents them from detecting and accurately interpreting subtle signals that otherwise would have alerted them that they are about to fall for a scam. Furthermore, their judgment is impaired very early in the disease process, often before other symptoms manifest themselves and usually before a diagnosis is made. Patients with early stages of dementia are therefore prime targets for unscrupulous predators, and it behooves caregivers and health care professionals to ensure the integrity of these patients...
January 2017: Gerontology & Geriatric Medicine
https://www.readbyqxmd.com/read/29042888/cognitive-stimulation-as-a-therapeutic-modality-for-dementia-a-meta-analysis
#2
Kayoung Kim, Ji Won Han, Yoonseop So, Jiyeong Seo, You Joung Kim, Joon Hyuk Park, Seok Bum Lee, Jung Jae Lee, Hyun-Ghang Jeong, Tae Hui Kim, Ki Woong Kim
OBJECTIVE: Although cognitive stimulation (CS) is one of the most popular non-pharmacological interventions for people with dementia, its efficacy is still debatable. We performed a meta-analysis of randomized controlled trials (RCTs) on the efficacy of CS in people with dementia. METHODS: Data sources were identified by searching PubMed, MEDLINE, Embase, psychINFO, and Cochrane Reviews Library. A total of 7,354 articles were identified, and of these, 30 RCTs were selected based on the selection criteria...
September 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/29040522/behavioral-and-transcriptomic-analysis-of-trem2-null-mice-not-all-knockout-mice-are-created-equal
#3
Silvia S Kang, Aishe Kurti, Kelsey E Baker, Chia-Chen Liu, Marco Colonna, Jason D Ulrich, David M Holtzman, Guojun Bu, John D Fryer
It is clear that innate immune system status is altered in numerous neurodegenerative diseases. Human genetic studies have demonstrated that Triggering Receptor Expressed in Myeloid cells 2 (TREM2) coding variants have a strong association with Alzheimer's disease (AD) and other neurodegenerative diseases. To more thoroughly understand the impact of TREM2 in vivo, we studied the behavioral and cognitive functions of wild-type (WT) and Trem2-/- (KO) mice during basal conditions and brain function in the context of innate immune stimulation with peripherally administered lipopolysaccharide (LPS)...
October 11, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/29036831/dementia-pugilistica-revisited
#4
Rudy J Castellani, George Perry
 Extensive exposure of boxers to neurotrauma in the early 20th century led to the so-called punch drunk syndrome, which was formally recognized in the medical literature in 1928. "Punch drunk" terminology was replaced by the less derisive 'dementia pugilistica' in 1937. In the early case material, the diagnosis of dementia pugilistica required neurological deficits, including slurring dysarthria, ataxia, pyramidal signs, extrapyramidal signs, memory impairment, and personality changes, although the specific clinical substrate has assumed lesser importance in recent years with a shift in focus on molecular pathogenesis...
October 8, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29036825/the-emergence-of-a-new-conceptual-framework-for-alzheimer-s-disease
#5
Dubois Bruno
The New Criteria for the diagnosis of Alzheimer's disease (AD), published by a group of experts in 2007, have resulted in a revolution in the comprehension of the disease. Before 2007, the diagnosis of AD dementia was done through a process of exclusion: it was considered in the case of patients with a dementia syndrome without identified etiologies. This traditional algorithm had three major limitations that penalize the disease: 1) a low accuracy of the performance which may share responsibility for negative results in clinical trials; 2) a late identification of the patients only when they reach the threshold of dementia which may delay the activation of optimal care; and last but not least, 3) an absence of clear recognition of AD as a disease because of the lack of specific arguments for its identification...
October 7, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29036823/prevalence-and-correlates-of-behavioral-disorders-in-old-age-subjects-with-cognitive-impairment-results-from-the-regal-project
#6
Virginia Boccardi, Manuela Conestabile Della Staffa, Marta Baroni, Sara Ercolani, Michele Francesco Croce, Carmelinda Ruggiero, Patrizia Mecocci
BACKGROUND: Presence of behavioral and psychological symptoms of dementia (BPSD) is very common in subjects with cognitive impairment, representing an important determinant of disease progression, institutionalization, and worse prognosis. Knowledge of the prevalence and correlates of BPSD in community-living old subjects with cognitive impairment is limited so far, but it is essential for establishing specifically tailored care and cure in such a vulnerable population. OBJECTIVE: With this study, we aimed at investigating, in a large sample of old age subjects with cognitive impairment, BPSD prevalence and correlates including the main demographic, clinical, and socio-environmental characteristics...
October 8, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29036821/estimated-glomerular-filtration-rate-is-not-associated-with-alzheimer-s-disease-in-a-northern-ireland-cohort
#7
Euan N Paterson, Michael A Williams, Peter Passmore, Giuliana Silvestri, Tom J MacGillivray, Alexander P Maxwell, Gareth J McKay
BACKGROUND: Alzheimer's disease (AD) prevalence is increasing globally and typically progresses for several years prior to clinical presentation of dementia. Renal dysfunction and vascular disease have been reported in association with dementia in several cross-sectional and longitudinal studies, and may contribute to AD risk. Experimental and observational studies suggest amyloid-β (Aβ) clearance may be impaired in chronic kidney disease (CKD) indicating a mechanism for increased AD risk...
October 11, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29035083/multiplicity-adjusted-semiparametric-benefiting-subgroup-identification-in-clinical-trials
#8
Patrick M Schnell, Peter Müller, Qi Tang, Bradley P Carlin
Background A recent focus in the health sciences has been the development of personalized medicine, which includes determining the population for which a given treatment is effective. Due to limited data, identifying the true benefiting population is a challenging task. To tackle this difficulty, the credible subgroups approach provides a pair of bounding subgroups for the true benefiting subgroup, constructed so that one is contained by the benefiting subgroup while the other contains the benefiting subgroup with high probability...
October 1, 2017: Clinical Trials: Journal of the Society for Clinical Trials
https://www.readbyqxmd.com/read/29032807/a-comparison-of-the-severe-cognitive-impairment-rating-scale-with-the-mini-mental-state-examination-and-delirium-rating-scale-revised-98-for-delirium-a-cross-sectional-study
#9
So-Hyun Ahn, Jin-Hoon Choi, Chae-Sung Im, Tae-Sung Kim, Jeong Lan Kim
BACKGROUND: Cognitive impairment including attention deficits, disorientation, memory impairment, language disturbance, and impaired visuospatial ability are core symptoms of delirium. The Severe Cognitive Impairment Rating Scale (SCIRS) was developed to assess cognition in patients with severe dementia, but may also be useful in elderly people with delirium. OBJECTIVE: We investigated the use of the SCIRS to assess cognition in elderly patients with delirium. METHODS: We recruited 147 participants, aged ≥65 years, referred for psychiatric consultation at a tertiary-care university hospital...
August 5, 2017: Psychosomatics
https://www.readbyqxmd.com/read/29031664/nonlinearity-aware-based-dimensionality-reduction-and-over-sampling-for-ad-mci-classification-from-mri-measures
#10
Peng Cao, Xiaoli Liu, Jinzhu Yang, Dazhe Zhao, Min Huang, Jian Zhang, Osmar Zaiane
Alzheimer's disease (AD) has been not only a substantial financial burden to the health care system but also an emotional burden to patients and their families. Making accurate diagnosis of AD based on brain magnetic resonance imaging (MRI) is becoming more and more critical and emphasized at the earliest stages. However, the high dimensionality and imbalanced data issues are two major challenges in the study of computer aided AD diagnosis. The greatest limitations of existing dimensionality reduction and over-sampling methods are that they assume a linear relationship between the MRI features (predictor) and the disease status (response)...
October 6, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29024348/obesity-as-a-risk-factor-for-alzheimer-s-disease-weighing-the-evidence
#11
REVIEW
S Alford, D Patel, N Perakakis, C S Mantzoros
Alzheimer's disease (AD) is the sixth leading cause of death in the USA today; therefore, it is imperative that public health initiatives and clinical strategies are developed to prevent and effectively treat AD. Despite the enormous impact that AD has on individuals, families, society, and the health care system, there are no biomarkers to clearly identify those at risk for AD, public health prevention strategies in place, or treatments to address the underlying pathology or stop the progression of AD. There is ample scientific as well as empirical evidence that obesity and its metabolic and vascular comorbidities are related to AD and likely in the causative pathway...
October 10, 2017: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29024027/rural-disparities-in-alzheimer-s-disease-related-community-pharmacy-care-in-the-united-states
#12
Paul Jacob Henkel, Marketa Marvanova
PURPOSE: To examine the relationship between area population density and community pharmacy-based Alzheimer's Disease (AD)-related services: pharmacists' medication knowledge and counseling, immunizations, and in-stock cognitive enhancers in 3 predominantly rural regions of the United States. METHODS: A standardized interview was administered by telephone to a 100% sample of community pharmacies in 3 areas: Northern California/Southern Oregon (n = 206), North and South Dakota (n = 278), and West Virginia (n = 420)...
October 10, 2017: Journal of Rural Health
https://www.readbyqxmd.com/read/29023987/prevalence-of-delusions-in-drug-na%C3%A3-ve-alzheimer-disease-patients-a-meta-analysis
#13
Leo Lai, Philip E Lee, Peter Chan, Mark C Fok, Ging-Yuek R Hsiung, Amir A Sepehry
INTRODUCTION: Neuropsychiatric symptoms (NPS) are common at all stages of Alzheimer disease (AD). Delusions in AD are associated with negative clinical consequences and may signal rapid disease progression. Hence, we sought to determine the prevalence of delusions in drug-naïve (no cholinesterase inhibitor or neuroleptic medications) AD patients. METHODS: In this meta-analysis, a search of the EMBASE, MEDLINE, and PsycINFO databases was performed. We selected studies reporting delusion prevalence measured by the Neuropsychiatric Inventory (NPI) in drug-naïve AD patients...
October 11, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29022278/alzheimer-caf%C3%A3-an-approach-focused-on-alzheimer-s-patients-but-with-remarkable-values-on-the-quality-of-life-of-their-caregivers
#14
Paola Merlo, Maria Devita, Alessandra Mandelli, Maria Luisa Rusconi, Raquel Taddeucci, Alice Terzi, Gianpiero Arosio, Maria Bellati, Maura Gavazzeni, Sara Mondini
BACKGROUND: Alzheimer's disease (AD) affects the global quality of life of persons who suffer from it and their caregivers, because of the behavioral and psychological consequences associated with the pathology and its caring. The Alzheimer Café (AC) is one example of approach aimed to help persons and caregivers deal with their disease. AIM: This is a pilot study focusing on the efficacy of AC in relieving caregivers' and persons' burdens due to dementia. METHODS: The quality of life of both caregivers and persons who attended the AC was compared with the quality of life of those who did not...
October 11, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29019964/building-iot-services-for-aging-in-place-using-standard-based-iot-platforms-and-heterogeneous-iot-products
#15
Sheik Mohammad Mostakim Fattah, Nak-Myoung Sung, Il-Yeup Ahn, Minwoo Ryu, Jaeseok Yun
An aging population and human longevity is a global trend. Many developed countries are struggling with the yearly increasing healthcare cost that dominantly affects their economy. At the same time, people living with old adults suffering from a progressive brain disorder such as Alzheimer's disease are enduring even more stress and depression than those patients while caring for them. Accordingly, seniors' ability to live independently and comfortably in their current home for as long as possible has been crucial to reduce the societal cost for caregiving and thus give family members peace of mind, called 'aging in place' (AIP)...
October 11, 2017: Sensors
https://www.readbyqxmd.com/read/29018524/re-evaluation-of-soluble-app-%C3%AE-and-app-%C3%AE-in-cerebrospinal-fluid-as-potential-biomarkers-for-early-diagnosis-of-dementia-disorders
#16
Wataru Araki, Kotaro Hattori, Kazutomi Kanemaru, Yuma Yokoi, Yoshie Omachi, Harumasa Takano, Masuhiro Sakata, Sumiko Yoshida, Tadashi Tsukamoto, Miho Murata, Yuko Saito, Hiroshi Kunugi, Yu-Ichi Goto, Utako Nagaoka, Masahiro Nagao, Takashi Komori, Kunimasa Arima, Kenji Ishii, Shigeo Murayama, Hiroshi Matsuda, Hisateru Tachimori, Yumiko M Araki, Hidehiro Mizusawa
BACKGROUND: Because soluble (or secreted) amyloid precursor protein-β (sAPPβ) and -α (sAPPα) possibly reflect pathological features of Alzheimer's disease (AD), they are potential biomarker candidates for dementia disorders, including AD and mild cognitive impairment (MCI) due to AD (MCI-AD). However, controversial results have been reported regarding their alterations in the cerebrospinal fluid (CSF) of AD and MCI-AD patients. In this study, we re-assessed the utility of sAPPα and sAPPβ in CSF as diagnostic biomarkers of dementia disorders...
2017: Biomarker Research
https://www.readbyqxmd.com/read/28987179/genetics-of-neurodegenerative-diseases-an-overview
#17
Lasse Pihlstrøm, Sarah Wiethoff, Henry Houlden
Genetic factors are central to the etiology of neurodegeneration, both as monogenic causes of heritable disease and as modifiers of susceptibility to complex, sporadic disorders. Over the last two decades, the identification of disease genes and risk loci has led to some of the greatest advances in medicine and invaluable insights into pathogenic mechanisms and disease pathways. Large-scale research efforts, novel study designs, and advances in methodology are rapidly expanding our understanding of the genome and the genetic architecture of neurodegenerative disease...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/28983881/alzheimer-s-disease-and-driving-review-of-the-literature-and-consensus-guideline-from-belgian-dementia-experts-and-the-belgian-road-safety-institute-endorsed-by-the-belgian-medical-association
#18
Jan Versijpt, Mark Tant, Ingo Beyer, Jean-Christophe Bier, Patrick Cras, Peter P De Deyn, Patrick De Wit, Olivier Deryck, Bernard Hanseeuw, Margareta Lambert, Jean-Claude Lemper, Eric Mormont, Mirko Petrovic, Gaetane Picard, Eric Salmon, Kurt Segers, Anne Sieben, Evert Thiery, Jos Tournoy, Maurits Vandewoude, Manfredi Ventura, Jurn Verschraegen, Sebastiaan Engelborghs, Tom Goffin, Michel Deneyer, Adrian Ivanoiu
Alzheimer's disease (AD) is a highly prevalent condition and its prevalence is expected to further increase due to the aging of the general population. It is obvious that the diagnosis of AD has implications for driving. Finally, driving discussions are also emotionally charged because driving is associated with independence and personal identity. However, it is not clear how to implement this in clinical practice and the Belgian law on driving is rather vague in its referral to neurodegenerative brain diseases in general nor does it provide clear-cut instructions for dementia or AD compared to for example driving for patients with epilepsy and as such does not prove to be very helpful...
October 5, 2017: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/28978226/social-engagement-and-antipsychotic-use-in-addressing-the-behavioral-and-psychological-symptoms-of-dementia-in-long-term-care-facilities
#19
Nasrin Saleh, Margaret Penning, Denise Cloutier, Anastasia Mallidou, Kim Nuernberger, Deanne Taylor
Objectives The use of antipsychotics, mainly to address the behavioral and psychological symptoms of dementia (BPSD), remains a common and frequent practice in long-term care facilities (LTCFs) despite their associated risks. The objective of this study was to explore the association between social engagement (SE) and the use of antipsychotics in addressing the BPSD in newly admitted residents to LTCFs. Methods A cross-sectional study was undertaken using administrative data, primarily the Resident Assessment Instrument Minimum Data Set (Version 2...
January 1, 2017: Canadian Journal of Nursing Research, Revue Canadienne de Recherche en Sciences Infirmières
https://www.readbyqxmd.com/read/28973985/s-adenosylmethionine-and-superoxide-dismutase-1-synergistically-counteract-alzheimer-s-disease-features-progression-in-tgcrnd8-mice
#20
Rosaria A Cavallaro, Vincenzina Nicolia, Maria Teresa Fiorenza, Sigfrido Scarpa, Andrea Fuso
Recent evidence emphasizes the role of dysregulated one-carbon metabolism in Alzheimer's Disease (AD). Exploiting a nutritional B-vitamin deficiency paradigm, we have previously shown that PSEN1 and BACE1 activity is modulated by one-carbon metabolism, leading to increased amyloid production. We have also demonstrated that S-adenosylmethionine (SAM) supplementation contrasted the AD-like features, induced by B-vitamin deficiency. In the present study, we expanded these observations by investigating the effects of SAM and SOD (Superoxide dismutase) association...
September 30, 2017: Antioxidants (Basel, Switzerland)
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