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https://www.readbyqxmd.com/read/28431511/validation-of-the-short-version-of-the-10-66-dementia-diagnosis-in-multiethnic-asian-older-adults-in-singapore
#1
Edimansyah Abdin, Janhavi Ajit Vaingankar, Louisa Picco, Boon Yiang Chua, Martin Prince, Siow Ann Chong, Mythily Subramaniam
BACKGROUND: To validate the short version of the 10/66 dementia diagnosis against the standard version of the 10/66 dementia diagnosis and clinical diagnosis and examine concurrent validity with the World Health Organisation Disability Assessment schedule and care needs in a multiethnic Asian older adult population in Singapore. METHODS: Data from the Well-being of the Singapore Elderly study, a nationally representative survey of the older Singapore Resident population aged 60 years and above was used...
April 21, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28429629/developing-indicators-of-appropriate-and-inappropriate-end-of-life-care-in-people-with-alzheimer-s-disease-cancer-or-chronic-obstructive-pulmonary-disease-for-population-level-administrative-databases-a-rand-ucla-appropriateness-study
#2
Robrecht De Schreye, Dirk Houttekier, Luc Deliens, Joachim Cohen
BACKGROUND: A substantial amount of aggressive life-prolonging treatments in the final stages of life has been reported for people with progressive life-shortening conditions. Monitoring appropriate and inappropriate end-of-life care is an important public health challenge and requires validated quality indicators. AIM: To develop indicators of appropriate and inappropriate end-of-life care for people with cancer, chronic obstructive pulmonary disease or Alzheimer's disease, measurable with population-level administrative data...
April 1, 2017: Palliative Medicine
https://www.readbyqxmd.com/read/28413821/cerebrospinal-fluid-biomarkers-for-alzheimer-s-disease-in-down-syndrome
#3
Alain D Dekker, Juan Fortea, Rafael Blesa, Peter P De Deyn
Down syndrome (DS), present in nearly six million people, is associated with an extremely high risk to develop Alzheimer's disease (AD). Amyloid-β and tau pathology are omnipresent from age 40 years onward, but clinical symptoms do not appear in all DS individuals. Dementia diagnostics is complex in this population, illustrating the great need for predictive biomarkers. Although blood biomarkers have not yet proven useful, cerebrospinal fluid (CSF) biomarkers (low amyloid-β42, high t-tau, and high p-tau) effectively contribute to AD diagnoses in the general population and are increasingly used in clinical practice...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28413014/-the-pasa-a-unique-place-of-interconnection
#4
REVIEW
Lutgarde Avinen, Marina Da Costa, Aurore Jammot, Stéphanie Robin, Jessica Vastel, Jean Bouisson
The PASA, a centre for adapted activities and care, enables nursing homes to become places of progress and innovation in the management of residents suffering from Alzheimer's disease and related conditions. The multidisciplinary approach and the convergence of new perspectives enables some to revive essential threads of their identity, and others to evolve and build themselves through more rewarding experiences.
March 2017: Soins. Gérontologie
https://www.readbyqxmd.com/read/28405748/translation-of-imaging-biomarkers-from-clinical-research-to-healthcare
#5
Ingo Kilimann, Jochen René Thyrian, Wolfgang Hoffmann, Stefan J Teipel
The use of biomarkers for diagnostics of Alzheimer's disease (AD) has increased over the last years in specialized care and experimental settings. With the possibly upcoming availability of disease-modifying therapeutic agents, the diagnostics and treatment of patients with cognitive impairment will change. Biomarkers will be used as theranostic markers for case finding. The development and evaluation of biomarkers can be framed in a phase model from preclinical studies through trials in expert center settings to the evaluation of biomarkers in primary care, up to testing the efficacy and the impact of biomarkers on the healthcare system...
April 12, 2017: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/28396304/comparing-crowdsourcing-and-friendsourcing-a-social-media-based-feasibility-study-to-support-alzheimer-disease-caregivers
#6
Daniel Robert Bateman, Erin Brady, David Wilkerson, Eun-Hye Yi, Yamini Karanam, Christopher M Callahan
BACKGROUND: In the United States, over 15 million informal caregivers provide unpaid care to people with Alzheimer disease (AD). Compared with others in their age group, AD caregivers have higher rates of stress, and medical and psychiatric illnesses. Psychosocial interventions improve the health of caregivers. However, constraints of time, distance, and availability inhibit the use of these services. Newer online technologies, such as social media, online groups, friendsourcing, and crowdsourcing, present alternative methods of delivering support...
April 10, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28395276/lower-visual-avoidance-in-dementia-patients-is-associated-with-greater-psychological-distress-in-caregivers
#7
Marcela C Otero, Robert W Levenson
Caring for a spouse with dementia can lead to increased health problems in caregivers. The present study examined whether patient deficits in visual avoidance, a common form of emotion regulation, are related to greater psychological distress in caregivers. Participants were 43 Alzheimer disease (AD) patients, 43 behavioral variant frontotemporal dementia (bvFTD) patients, and their spousal caregivers. Patient visual avoidance (e.g., gaze aversion) was measured using behavioral coding of head, body, and eye position while viewing a disgusting film...
April 11, 2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/28389758/comparison-of-outcomes-of-operative-versus-non-operative-treatment-of-acetabular-fractures-in-the-elderly-and-severely-comorbid-patient
#8
Kempland C Walley, P T Appleton, E K Rodriguez
BACKGROUND: Acetabular fractures in the elderly and severely comorbid patient can be associated with high morbidity and mortality; however, differences in outcomes of acute ORIF versus non-operative care of acetabular fractures in a subgroup of elderly (>75 years) and/or severely comorbid younger patients (>65) remain unclear. PATIENTS AND METHODS: A retrospective review of 243 patients who sustained an acetabular fracture between April 2005 and November 2014 was performed...
April 7, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28386806/-people-with-dementia-in-primary-care-prevalence-incidence-risk-factors-and-interventions
#9
Jochen René Thyrian
BACKGROUND: Approximately 110 years after the first description of Alzheimer's disease (AD) healthcare systems worldwide face the challenge of increasing numbers of people affected by dementia. There is a need to develop (national) dementia plans on a societal level to implement strategies to combat these challenges. These plans, among other topics, explicitly aim at scientific and research strategies as well as support and healthcare structures. OBJECTIVE: This article describes a selection of current healthcare research studies and projects in Germany...
April 6, 2017: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/28385550/currents-of-memory-recent-progress-translational-challenges-and-ethical-considerations-in-fornix-deep-brain-stimulation-trials-for-alzheimer-s-disease
#10
REVIEW
John Noel M Viaña, James C Vickers, Mark J Cook, Frederic Gilbert
The serendipitous discovery of triggered autobiographical memories and eventual memory improvement in an obese patient who received fornix deep brain stimulation in 2008 paved the way for several phase I and phase II clinical trials focused on the safety and efficacy of this potential intervention for people with Alzheimer's disease. In this article, we summarize clinical trials and case reports on fornix deep brain stimulation for Alzheimer's disease and review experiments on animal models evaluating the physiological or behavioral effects of this intervention...
March 11, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28383687/neuropsychiatric-symptoms-in-alzheimer-s-disease-associations-with-caregiver-burden-and-treatment-outcomes
#11
Chao Tung Chen, Chiung-Chih Chang, Wen-Neng Chang, Nai-Wen Tsai, Chih-Cheng Huang, Ya-Ting Chang, Hung-Chen Wang, Chia-Te Kung, Yu-Jih Su, Wei-Che Lin, Ben-Chung Cheng, Chih-Min Su, Sheng-Yuan Hsiao, Che-Wei Hsu, Cheng-Hsien Lu
Background: Caregivers play a major role in providing care for patients with Alzheimer's disease (AD) and are themselves at higher risk of health comorbidities. Aim: To address the impact of neuropsychiatric symptoms of patients in different stages of AD on their caregivers' burden. Design: This prospective study enrolled 260 AD patients with clinical dementia rating of 0.5, 1, and 2 at a tertiary medical center. Methods: All patients were tested using the Mini-Mental State Examination (MMSE), the Cognitive Abilities Screening Instrument (CASI), the Neuropsychiatric Inventory (NPI), and the Clinical Dementia Rating scale (CDR)...
April 5, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/28380342/association-of-subjective-memory-complaint-and-depressive-symptoms-with-objective-cognitive-functions-in-prodromal-alzheimer-s-disease-including-pre-mild-cognitive-impairment
#12
Eun Hyun Seo, Hoowon Kim, Kyu Yeong Choi, Kun Ho Lee, Il Han Choo
BACKGROUND: Subjective memory complaints (SMC) and depressive symptoms (SDS) are common in the elderly population. However, the relationship among SMC, SDS, and cognitive function remains unclear. We investigated these associations in the elderly from cognitively normal (CN), pre-mild cognitive impairment (MCI), and amnestic MCI (aMCI) groups. METHODS: Participants (CN, 299; pre-MCI, 106; aMCI, 267) underwent comprehensive clinical and neuropsychological assessment...
March 30, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28378011/%C3%AE-scores-predict-mild-cognitive-impairment-and-alzheimer-s-disease-conversions-from-nondemented-states
#13
Donald R Royall, Raymond F Palmer
INTRODUCTION: We tested the latent variable "δ" (for "dementia")'s ability to predict conversion to "mild cognitive impairment" (MCI) and Alzheimer's disease (AD). METHODS: An ethnicity equivalent d homolog ("dEQ") was constructed in n = 1113 Mexican- American (MA) and n = 1958 non-Hispanic white (NHW) participants in the Texas Alzheimer's Research and Care Consortium. "Normal Controls" (NC) (n = 1276) and MCI cases (n = 611) were followed annually for up to 6 years [m = 4...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28372635/trends-in-the-prescribing-of-atypical-antipsychotics-in-elderly-patients-with-dementia-in-korea%C3%A2
#14
Namjoo Seo, Inmyung Song, Heyekyung Park, Dongmun Ha, Ju-Young Shin
OBJECTIVE: In 2005, the Food and Drug Administration warned that atypical antipsychotics (AAPs) increased mortality in elderly patients with dementia. We investigated AAP prescribing in elderly patients with dementia in the ambulatory setting in Korea and the factors affecting AAP prescribing in elderly patients with dementia. METHODS: Subjects ≥ 65 years of age with at least one diagnosis of dementia (ICD-10: F00-F03, G30, G31.8) from January 1 to December 31, 2013 were identified from a health insurance database...
April 4, 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28360418/not-just-amyloid-physiological-functions-of-the-amyloid-precursor-protein-family
#15
REVIEW
Ulrike C Müller, Thomas Deller, Martin Korte
Amyloid precursor protein (APP) gives rise to the amyloid-β peptide and thus has a key role in the pathogenesis of Alzheimer disease. By contrast, the physiological functions of APP and the closely related APP-like proteins (APLPs) remain less well understood. Studying these physiological functions has been challenging and has required a careful long-term strategy, including the analysis of different App-knockout and Aplp-knockout mice. In this Review, we summarize these findings, focusing on the in vivo roles of APP family members and their processing products for CNS development, synapse formation and function, brain injury and neuroprotection, as well as ageing...
May 2017: Nature Reviews. Neuroscience
https://www.readbyqxmd.com/read/28359849/a-review-on-traditional-uses-phytochemistry-pharmacology-pharmacokinetics-and-toxicology-of-the-genus-peganum
#16
REVIEW
Shuping Li, Xuemei Cheng, Changhong Wang
ETHNOPHARMACOLOGICAL RELEVANCE: The plants of the genus Peganum have a long history as a Chinese traditional medicine for the treatment of cough, hypertension, diabetes, asthma, jaundice, colic, lumbago, and many other human ailments. Additionally, the plants can be used as an amulet against evil-eye, dye and so on, which have become increasingly popular in Asia, Iran, Northwest India, and North Africa. AIM OF THE REVIEW: The present paper reviewed the ethnopharmacology, phytochemistry, analytical methods, biological activities, metabolism, pharmacokinetics, toxicology, and drug interaction of the genus Peganum in order to assess the ethnopharmacological use and to explore therapeutic potentials and future opportunities for research...
March 27, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28357874/gender-s-effects-to-the-early-symptoms-of-alzheimer-s-disease-in-5-asian-countries
#17
Yuan-Han Yang, Kenichi Meguro, Jacqueline Dominguez, Christopher Li-Hsian Chen, Huali Wang, Paulus Anam Ong
BACKGROUND: Asia has the greatest population and more patients with dementia in the world. Early recognition of clinical symptoms of Alzheimer's disease (AD) is crucial for dementia care. In order to foster collaboration in AD care, a uniformed manner to report the early clinical symptoms of AD is necessary. METHODS: We have recruited clinically diagnosed patients with AD at their very mild stage with Clinical Dementia Rating (CDR) 0.5 in Taiwan, Japan, China, Philippines, and Singapore...
January 1, 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/28352208/patient-rated-versus-proxy-rated-cognitive-and-functional-measures-in-older-adults
#18
Molly Howland, Kevin C Allan, Caitlin E Carlton, Curtis Tatsuoka, Kathleen A Smyth, Martha Sajatovic
OBJECTIVES: Patients with cognitive impairment may have difficulty reporting their functional and cognitive abilities, which are important clinical outcomes. Health care proxies may be able to corroborate patient self-reports. Several studies reported discrepancy between patient and proxy ratings, though the literature is sparse on changes over time of these ratings. Our goals in this 12-month study were to compare patient and proxy reports on functioning, cognition, and everyday executive function, and to further elucidate correlates of patient-proxy discrepancy...
2017: Patient related Outcome Measures
https://www.readbyqxmd.com/read/28351177/direct-and-indirect-cost-of-managing-alzheimer-s-disease-and-related-dementias-in-the-united-states
#19
Arijita Deb, James Douglas Thornton, Usha Sambamoorthi, Kim Innes
Introduction Care of individuals with Alzheimer's Disease and Related Dementias (ADRD) poses special challenges. As the disease progresses, individuals with ADRD require increasing levels of medical care, caregiver support, and long-term care which can lead to substantial economic burden. Areas Covered In this expert review, we synthesized findings from studies of costs of ADRD in the United States that were published between January 2006 and February 2017, highlighted major sources of variation in costs, identified knowledge gaps and briefly outlined directions for future research and implications for policy and program planning...
March 29, 2017: Expert Review of Pharmacoeconomics & Outcomes Research
https://www.readbyqxmd.com/read/28342649/the-prognosis-of-dementia-with-lewy-bodies
#20
REVIEW
Christoph Mueller, Clive Ballard, Anne Corbett, Dag Aarsland
Dementia with Lewy bodies is the second most common form of neurodegenerative dementia, yet scarce evidence is available about its prognosis and natural history, which are crucial to inform clinical practice and research. Patients with dementia with Lewy bodies might have a less favourable prognosis, with accelerated cognitive decline, shorter lifespan, and increased admission to residential care than patients with Alzheimer's disease. Health-care costs and, importantly, caregiver burden, are also reported to be higher in dementia with Lewy bodies than in Alzheimer's disease...
May 2017: Lancet Neurology
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