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Nefopam

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https://www.readbyqxmd.com/read/29686808/effects-of-warmed-carrier-fluid-on-nefopam-injection-induced-pain
#1
Hyung Rae Cho, Seon Hwan Kim, Jin A Kim, Jin Hye Min, Yong Kyung Lee
Background: Nefopam is a non-opioid, non-steroidal analgesic drug with fewer adverse effects than narcotic analgesics and nonsteroidal anti-inflammatory drugs, and is widely used for postoperative pain control. Because nefopam sometimes causes side effects such as nausea, vomiting, somnolence, hyperhidrosis and injection-related pain, manufacturers are advised to infuse it slowly, over a duration of 15 minutes. Nevertheless, pain at the injection site is very common. Therefore, we investigated the effect of warmed carrier fluid on nefopam injection-induced pain...
April 2018: Korean Journal of Pain
https://www.readbyqxmd.com/read/29684987/effects-of-nefopam-on-catheter-related-bladder-discomfort-in-patients-undergoing-ureteroscopic-litholapaxy
#2
Yong Woo Cheon, Seon Hwan Kim, Jin Hyub Paek, Jin A Kim, Yong Kyung Lee, Jin Hye Min, Hyung Rae Cho
Background: Patients who undergo urinary catheterization may experience postoperative catheter-related bladder discomfort (CRBD). Previous studies have indicated that drugs with antimuscarinic effects could reduce the incidence and severity of CRBD. Accordingly, this study was carried out to investigate whether nefopam, a centrally acting analgesic with concomitant antimuscarinic effect, reduces the incidence and severity of CRBD. Methods: Sixty patients with American Society of Anesthesiologists physical status I and II and aged 18-70 years who were scheduled to undergo elective ureteroscopic litholapaxy participated in this double-blinded study...
April 24, 2018: Korean Journal of Anesthesiology
https://www.readbyqxmd.com/read/29536252/bupivacaine-wound-infiltration-reduces-postoperative-pain-and-analgesic-requirement-after-thyroid-surgery
#3
Moncef Sellami, Sarhan Feki, Zied Triki, Jamil Zghal, Imen Zouche, Boutheina Hammami, Ilhem Charfeddine, Mohamed Chaari, Abdelmonem Ghorbel
BACKGROUND AND OBJECTIVE: We conducted a prospective double-blind randomized study assessing bupivacaine end-of-surgery wound infiltration for pain relief in thyroid surgery. METHODS: Patients were randomly divided into two groups: Group S, local wound infiltration with saline solution; Group B, bupivacaine 0.5% was administered. Pain perception was measured using visual analogue scale (VAS) during post-anaesthetic care unit (PACU) stay every 10 min and during the 24 postoperative hours admission at 2, 4, 6, 12, and 24 h after surgery...
May 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29517677/the-efficacy-and-safety-of-nefopam-for-pain-relief-during-laparoscopic-cholecystectomy-a-meta-analysis
#4
REVIEW
Tiancheng Zhao, Zhen Shen, Shihou Sheng
BACKGROUND: Pain control after laparoscopic cholecystectomy (LC) has become an important topic. We performed a meta-analysis of randomized controlled trials (RCTs) to evaluate the efficacy and safety of nefopam for pain management after LC. METHODS: PubMed, Medline, Embase, ScienceDirect, and the Cochrane Library were searched up to November 2017 for comparative articles involving nefopam and placebo for reducing postoperative pain after LC. Primary outcomes were postoperative pain scores and opioid consumption...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29479974/effects-of-nefopam-with-fentanyl-in-intravenous-patient-controlled-analgesia-after-arthroscopic-orthopedic-surgery-a-prospective-double-blind-randomized-trial
#5
You Na Oh, Kyu Nam Kim, Mi Ae Jeong, Dong Won Kim, Ji Yoon Kim, Hyun Seo Ki
Background/aim: We performed this prospective randomized double-blind study to compare the effects of nefopam versus ketorolac in intravenous fentanyl-based patient-controlled analgesia (PCA) after shoulder arthroscopic orthopedic surgery. Materials and methods: Ninety-two patients were randomly divided into two groups to receive intravenous PCA. Patients were assigned to either the nefopam group (nefopam 120 mg and fentanyl 20 µg/kg) or the ketorolac group (ketorolac 2 mg/kg and fentanyl 20 µg/kg). Pain was assessed on a visual analogue scale (VAS) and a numeric rating scale (NRS)...
February 23, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29435278/enhanced-analgesic-effects-of-nefopam-in-combination-with-acetaminophen-in-rodents
#6
Qian Li, Quankun Zhuang, Yaru Gu, Cailing Dai, Xiaoxiao Gao, Xiaomin Wang, Huimin Wen, Xin Li, Yuyang Zhang
Nefopam, an analgesic drug, effectively elicits antinociception in the majority of noxious and thermal models in rodents. Acetaminophen is among the most commonly used analgesic and antipyretic drugs worldwide, either on prescription or over the counter. The present study aimed to investigate the analgesic activity of nefopam combined with acetaminophen, which was expected to maximize the potency of analgesia and decrease the dose of nefopam required. Three series of experiments, namely acetic acid-induced writhing tests in mice, hot plate tests in mice and tail flick tests in rats, were used to evaluate the analgesic effect...
February 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29384419/procedural-sedation-and-analgesia-in-trauma-patients-in-an-out-of-hospital-emergency-setting-a-prospective-multicenter-observational-study
#7
Michel Galinski, Laure Hoffman, Delphine Bregeaud, Mounir Kamboua, François-Xavier Ageron, Catherine Rouanet, Jean-Christophe Hubert, Jacques Istria, Mirko Ruscev, Karim Tazarourte, Florence Pevirieri, Frédéric Lapostolle, Frédéric Adnet
BACKGROUND: The quality of procedural analgesia and sedation among trauma patients has not been studied much in the prehospital setting. The main objective of this study was to characterize the quality of procedural analgesia sedation practices in prehospital settings in trauma patients. METHODS: This was an open-label observational prospective multicenter study (January 01, 2012-December 31, 2013). We included all consecutive trauma victims undergoing a potentially painful procedure on the accident scene...
January 31, 2018: Prehospital Emergency Care
https://www.readbyqxmd.com/read/29381993/effects-of-nefopam-on-emergence-agitation-after-general-anesthesia-for-nasal-surgery-a-prospective-randomized-and-controlled-trial
#8
RANDOMIZED CONTROLLED TRIAL
Young Seok Jee, Hwang-Ju You, Tae-Yun Sung, Choon-Kyu Cho
BACKGROUND: Emergence agitation (EA) occurs frequently after nasal surgery. N-methyl-D-aspartate (NMDA) receptor antagonists and analgesics, such as fentanyl, have been shown to prevent EA. Nefopam inhibits the NMDA receptor and shows a potent analgesic effect. We investigated the effects of nefopam on EA in patients undergoing nasal surgery. METHODS: In this prospective, double-blind study, 100 adult patients were allocated randomly to 1 of 2 groups (each n = 50)...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29374350/intraoperative-nefopam-reduces-acute-postoperative-pain-after-laparoscopic-gastrectomy-a-prospective-randomized-study
#9
Hyo-Seok Na, Ah-Young Oh, Jung-Hee Ryu, Bon-Wook Koo, Sun-Woo Nam, Jihoon Jo, Jae-Hee Park
BACKGROUND: We assessed whether intraoperative nefopam would reduce opioid consumption and relieve postoperative pain in patients undergoing laparoscopic gastrectomy. METHODS: The 60 enrolled patients were randomly assigned to the control (n = 32) or nefopam (n = 28) group. All patients were blinded to their group assignment. We administered 100 ml of normal saline only (control group) or 20 mg of nefopam mixed in 100 ml normal saline (nefopam group) after anesthesia induction and at the end of surgery...
January 26, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29336385/prophylaxis-of-postoperative-nausea-and-vomiting-after-cardiac-surgery-in-high-risk-patients-a-randomized-controlled-study
#10
Sébastien Champion, Laëtitia Zieger, Caroline Hemery
CONTEXT: The role of prophylaxis for postoperative nausea and vomiting (PONV) in cardiac surgery is under debate. AIMS: To study the risk factors for PONV after cardiac surgery and the role of betamethasone with or without droperidol for its prevention. SETTING AND DESIGN: Randomized open-label controlled study comparing standard care with PONV prophylaxis from February to November 2016. METHODS: Five hundred and two patients with planned nonemergent cardiac surgery were included...
January 2018: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/29305813/a-simultaneous-mixed-effects-pharmacokinetic-model-for-nefopam-n-desmethylnefopam-and-nefopam-n-oxide-in-human-plasma-and-urine
#11
Aravind Mittur
BACKGROUND AND OBJECTIVE: Nefopam is a non-opioid, non-steroidal, central analgesic thought to act via multiple mechanisms including potent inhibition of serotonin-norepinephrine reuptake and modulation of voltage-sensitive calcium and sodium channels. There has been a resurgence in its use for postoperative pain and neuropathic pain. Dosing route-dependent metabolism and clinical effects have been described following intravenous and oral nefopam. N-desmethylnefopam and nefopam N-oxide are metabolites of clinical interest...
January 5, 2018: European Journal of Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/29288309/the-effect-of-intraoperative-nefopam-administration-on-acute-postoperative-pain-and-chronic-discomfort-after-robotic-or-endoscopic-assisted-thyroidectomy-a-randomized-clinical-trial
#12
B G Kim, J Y Moon, J Y Choi, I S Park, A Y Oh, Y T Jeon, J W Hwang, J H Ryu
BACKGROUND: Acute postoperative pain and chronic discomfort are reported after robotic or endoscopic thyroidectomy. The purpose of this prospective, randomized, and double-blinded clinical trial was to investigate whether intraoperative infusion of nefopam decreases acute postoperative pain and chronic discomfort following either a robotic or endoscopic thyroidectomy via the bilateral axillo-breast approach (BABA). METHODS: Patients were randomized into two groups: The control group (n = 29) or the nefopam group (n = 29)...
December 29, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29225744/a-comparison-between-ketorolac-and-nefopam-as-adjuvant-analgesics-for-postoperative-patient-controlled-analgesia-a-randomized-double-blind-prospective-study
#13
Ji-Seon Son, Aram Doo, Young-Jun Kwon, Young-Jin Han, Seonghoon Ko
Background: We compared the analgesic efficacy and side effects of ketorolac and nefopam that were co-administered with fentanyl via intravenous patient-controlled analgesia. Methods: One hundred and sixty patients scheduled for laparoscopic cholecystectomy were randomly assigned to ketorolac (Group K) or nefopam (Group N) groups. The anesthetic regimen was standardized for all patients. The analgesic solution contained fentanyl 600 µg and ketorolac 180 mg in Group K, and fentanyl 600 µg and nefopam 120 mg in Group N...
December 2017: Korean Journal of Anesthesiology
https://www.readbyqxmd.com/read/28971527/investigation-of-maltodextrin-based-synergistic-system-with-amino-acid-chiral-ionic-liquid-as-additive-for-enantioseparation-in-capillary-electrophoresis
#14
Jiaquan Chen, Yingxiang Du, Xiaodong Sun
The combined use of chiral ionic liquids (ILs) and chiral selectors in capillary electrophoresis (CE) to establish a synergistic system has proven to be an effective approach for enantioseparation. In this article, tetramethylammonium-L-arginine, a kind of amino acid chiral IL, was applied to investigate its potential synergistic effect with maltodextrin in CE enantioseparation. The established maltodextrin-based synergistic system showed markedly improved enantioseparations compared with the single maltodextrin system...
December 2017: Chirality
https://www.readbyqxmd.com/read/28638273/the-effect-of-nefopam-infusion-during-laparascopic-cholecystectomy-on-postoperative-pain
#15
Eun Mi Kim, Joo Hyun Jeon, Mi Hwa Chung, Eun Mi Choi, Seung Hwa Baek, Pil Hyun Jeon, Mi Hyeon Lee
Background: While recovery from remifentanil is fast due to its rapid metabolism, it can induce hyperalgesia by activation of N-methyl-D-aspartic acid (NMDA) receptors. Therefore, administration of NMDA receptor antagonists such as ketamine is effective in relieving hyperalgesia caused by remifentanil. A previous study showed that nefopam administration before anesthesia combined with low-dose remifentanil reduced pain and analgesic consumption during the immediate postoperative period. We hypothesized that intraoperative infusion of nefopam during laparoscopic cholecystectomy would be as effective as ketamine in controlling pain during the acute postoperative period after sevoflurane and remifentanil based anesthesia...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/28375984/inadvertent-intrathecal-injection-of-nefopam-during-spinal-anaesthesia-a-case-report
#16
Emmanuelle Loyrion, Gilles Francony, Dan Benhamou, Pierre Albaladejo
No abstract text is available yet for this article.
May 2017: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/28347572/the-effect-of-nefopam-on-lactation-after-caesarean-section-a-single-blind-randomised-trial
#17
N E Baka, F Vial, G Iohom, P Guerci, C Hubert, M Rouabah, H Bouaziz
BACKGROUND: Nefopam is a centrally acting analgesic which has a theoretical risk of stopping lactation due to its anticholinergic and dopaminergic effects. The aim of this study was to evaluate the effect of nefopam on lactation and to investigate potential adverse effects on newborns. METHODS: Seventy-two women, scheduled to undergo a caesarean delivery under spinal anaesthesia and wanting to breastfeed, were randomised to one of two groups: nefopam (20mg, six hourly) or paracetamol (1g, six hourly)...
February 20, 2017: International Journal of Obstetric Anesthesia
https://www.readbyqxmd.com/read/28323508/nefopam-hydrochloride-loaded-microspheres-for-post-operative-pain-management-synthesis-physicochemical-characterization-and-in-vivo-evaluation
#18
Neelam Sharma, Sandeep Arora, Jitender Madan
Once-daily oral dosage of nefopam hydrochloride loaded sustained release microspheres (NPH-MS) was investigated as novel therapeutic strategy for post-operative pain management. Microspheres were synthesized using poly-3-hydroxybutyrate and poly-(ɛ-caprolactone) by double emulsion solvent evaporation technique. NPH-MS were characterized through FTIR, PXRD and SEM. In-vitro drug release study revealed sustained behavior till 24 h. Haemolysis was <5% which signified haemocompatibility of formulation. ED50 in rat tail-flick anti-nociceptive test was found ∼18...
February 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28254468/pharmacologically-targeting-beta-catenin-for-nf1-associated-deficiencies-in-fracture-repair
#19
Gurpreet S Baht, Puviindran Nadesan, David Silkstone, Benjamin A Alman
Patients with Neurofibromatosis type 1 display delayed fracture healing and the increased deposition of fibrous tissue at the fracture site. Severe cases can lead to non-union and even congenital pseudarthrosis. Neurofibromatosis type 1 is caused by a mutation in the NF1 gene and mice lacking the Nf1 gene show a fracture repair phenotype similar to that seen in patients. Tissue from the fracture site of patients with Neurofibromatosis type 1 and from mice deficient in the Nf1 gene both show elevated levels of β-catenin protein and activation of β-catenin mediated signaling...
May 2017: Bone
https://www.readbyqxmd.com/read/28192892/opioid-sparing-effect-of-nefopam-in-combination-with-paracetamol-after-major-abdominal-surgery-a-randomized-double-blind-study
#20
Philippe Cuvillon, Lana Zoric, Christophe Demattei, Sandrine Alonso, Françoise Casano, Joel L'hermite, Jacques Ripart, Jean-Yves Lefrant, Laurent Muller
BACKGROUND: Because nefopam's morphine-sparing is debated when combined with paracetamol, this study aimed to assess pain relief by IV nefopam in combination with paracetamol after major abdominal surgery. METHODS: This was a prospective, double-blinded randomized controlled study including patients (ASA I-III, >18 years) scheduled for elective colectomy surgery by laparotomy. Patients were randomized into the nefopam group (N.=37, continuous IV 120 mg nefopam) or control group (N...
September 2017: Minerva Anestesiologica
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