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Nefopam

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https://www.readbyqxmd.com/read/28323508/nefopam-hydrochloride-loaded-microspheres-for-post-operative-pain-management-synthesis-physicochemical-characterization-and-in-vivo-evaluation
#1
Neelam Sharma, Sandeep Arora, Jitender Madan
Once-daily oral dosage of nefopam hydrochloride loaded sustained release microspheres (NPH-MS) was investigated as novel therapeutic strategy for post-operative pain management. Microspheres were synthesized using poly-3-hydroxybutyrate and poly-(ɛ-caprolactone) by double emulsion solvent evaporation technique. NPH-MS were characterized through FTIR, PXRD and SEM. In-vitro drug release study revealed sustained behavior till 24 h. Haemolysis was <5% which signified haemocompatibility of formulation. ED50 in rat tail-flick anti-nociceptive test was found ∼18...
March 21, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28254468/pharmacologically-targeting-beta-catenin-for-nf1-associated-deficiencies-in-fracture-repair
#2
Gurpreet S Baht, Puviindran Nadesan, David Silkstone, Benjamin A Alman
Patients with Neurofibromatosis type 1 display delayed fracture healing and the increased deposition of fibrous tissue at the fracture site. Severe cases can lead to non-union and even congenital pseudarthrosis. Neurofibromatosis type 1 is caused by a mutation in the NF1 gene and mice lacking the Nf1 gene show a fracture repair phenotype similar to that seen in patients. Tissue from the fracture site of patients with Neurofibromatosis type 1 and from mice deficient in the Nf1 gene both show elevated levels of β-catenin protein and activation of β-catenin mediated signaling...
February 22, 2017: Bone
https://www.readbyqxmd.com/read/28192892/opioid-sparing-effect-of-nefopam-in-combination-with-paracetamol-after-major-abdominal-surgery-a-randomized-double-blind-study
#3
Philippe Cuvillon, Lana Zoric, Christophe Demattei, Sandrine Alonso, Francoise Casano, Joel L'hermite, Jacques Ripart, Jean-Yves Lefrant, Laurent Muller
BACKGROUND: Because nefopam's morphine-sparing is debated when combined with paracetamol, this study aimed to assess pain relief by IV nefopam in combination with paracetamol after major abdominal surgery. METHODS: This was a prospective, double-blinded randomized controlled study including patients (ASA I-III, > 18 y) scheduled for elective colectomy surgery by laparotomy. Patients were randomized into the nefopam group (n = 37, continuous IV 120 mg nefopam) or control group (N...
February 13, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/28117122/carboxylated-single-walled-carbon-nanotube-functionalized-chiral-polymer-monoliths-for-affinity-capillary-electrochromatography
#4
Chunyue Miao, Ruihan Bai, Shujuan Xu, Tingting Hong, Yibing Ji
Carboxylated single-walled carbon nanotubes (c-SWNTs) were incorporated into poly(glycidylmethacrylate-co-ethylene glycol dimethacrylate) [poly(GMA-co-EDMA)] monoliths to develop a novel monolithic stationary phase for capillary electrochromatography. The prepared monoliths were characterized by scanning electron microscopy and nitrogen adsorption. Additionally, pepsin, which is a chiral selector, was bonded to the c-SWNT-incorporated monoliths via epoxide groups as reactive sites and glutaraldehyde as the spacer...
March 3, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28039239/non-opioid-analgesics-in-adults-after-major-surgery-systematic-review-with-network-meta-analysis-of-randomized-trials
#5
V Martinez, H Beloeil, E Marret, D Fletcher, P Ravaud, L Trinquart
BACKGROUND: Morphine, and analgesics other than morphine (AOM), are commonly used to treat postoperative pain after major surgery. However, which AOM provides the best efficacy-safety profile remains unclear. METHODS: Randomized trials of any AOM alone or any combination of AOM compared with placebo or another AOM in adults undergoing major surgery and receiving morphine patient-controlled analgesia were included in a network meta-analysis. The outcomes were morphine consumption, pain, incidence of nausea, vomiting at 24 h and severe adverse effects...
January 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/27924198/comparison-of-effect-of-electroacupuncture-and-nefopam-for-prevention-of-postanesthetic-shivering-in-patients-undergoing-urologic-operation-under-spinal-anesthesia
#6
Jun-Ho Hong, Su-Jin Kim, Min-Sub Hwang
BACKGROUND: Shivering during spinal anesthesia is a frequent complication and is induced by the core-to-peripheral redistribution of heat. Nefopam has minimal side effects and prevents shivering by reducing the shivering threshold. Electroacupuncture is known to prevent shivering by preserving the core body temperature. We compared the efficacies of electroacupuncture and nefopam for the prevention of shivering during spinal anesthesia. METHODS: Ninety patients scheduled for elective urological surgery under spinal anesthesia were enrolled in the study...
December 2016: Korean Journal of Anesthesiology
https://www.readbyqxmd.com/read/27752232/development-and-statistical-optimization-of-nefopam-hydrochloride-loaded-nanospheres-for-neuropathic-pain-using-box-behnken-design
#7
S Sukhbir, S Yashpal, A Sandeep
Nefopam hydrochloride (NFH) is a non-opioid centrally acting analgesic drug used to treat chronic condition such as neuropathic pain. In current research, sustained release nefopam hydrochloride loaded nanospheres (NFH-NS) were auspiciously synthesized using binary mixture of eudragit RL 100 and RS 100 with sorbitan monooleate as surfactant by quasi solvent diffusion technique and optimized by 3(5) Box-Behnken designs to evaluate the effects of process and formulation variables. Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetric (DSC) and X-ray diffraction (XRD) affirmed absence of drug-polymer incompatibility and confirmed formation of nanospheres...
September 2016: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/27703629/comparison-of-effects-of-intraoperative-nefopam-and-ketamine-infusion-on-managing-postoperative-pain-after-laparoscopic-cholecystectomy-administered-remifentanil
#8
Sung Kwan Choi, Myung Ha Yoon, Jung Il Choi, Woong Mo Kim, Bong Ha Heo, Keun Seok Park, Ji A Song
BACKGROUND: Although intraoperative opioids provide more comfortable anesthesia and reduce the use of postoperative analgesics, it may cause opioid induced hyperalgesia (OIH). OIH is an increased pain response to opioids and it may be associated with N-methyl-D-aspartate (NMDA) receptor. This study aimed to determine whether intraoperative nefopam or ketamine, known being related on NMDA receptor, affects postoperative pain and OIH after continuous infusion of intraoperative remifentanil...
October 2016: Korean Journal of Anesthesiology
https://www.readbyqxmd.com/read/27689348/neither-nefopam-nor-acetaminophen-can-be-used-as-postoperative-analgesics-in-a-rat-model-of-ischemic-stroke
#9
Maud Pétrault, Sophie Gautier, Vincent Bérézowski, Thavarak Ouk, Michèle Bastide, Olivier Pétrault, Régis Bordet
Analgesics such as opioid agonists are usually not given during the postoperative phase of experimental stroke because they are susceptible to interfere with the evaluation of neuroprotective therapies. Here, we investigate the potential of acetaminophen and nefopam, two nonopioid analgesic drugs, to exert an analgesic effect without inducing neuroprotection in a murine model of ischemic stroke. We demonstrate that acetaminophen (200 mg/kg, PO) induces a significant decrease in the infarct volume, particularly in the cortex (VEHICLE: 200...
September 30, 2016: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/27625488/factors-affecting-recovery-of-postoperative-bowel-function-after-pediatric-laparoscopic-surgery
#10
Daphnée Michelet, Juliette Andreu-Gallien, Alia Skhiri, Arnaud Bonnard, Yves Nivoche, Souhayl Dahmani
BACKGROUND AND AIMS: Laparoscopic pediatric surgery allows a rapid postoperative rehabilitation and hospital discharge. However, the optimal postoperative pain management preserving advantages of this surgical technique remains to be determined. This study aimed to identify factors affecting the postoperative recovery of bowel function after laparoscopic surgery in children. MATERIAL AND METHODS: A retrospective analysis of factors affecting recovery of bowel function in children and infants undergoing laparoscopic surgery between January 1, 2009 and September 30, 2009, was performed...
July 2016: Journal of Anaesthesiology, Clinical Pharmacology
https://www.readbyqxmd.com/read/27453381/unravelling-the-binding-mechanism-and-protein-stability-of-human-serum-albumin-while-interacting-with-nefopam-analogues-a-biophysical-and-insilico-approach
#11
Mahesh Gokara, Vidadala V Narayana, Vineet Sadarangani, Shatabdi Roy Chowdhury, Sreelaxmi Varkala, Dhevalapally B Ramachary, Rajagopal Subramanyam
In this study, molecular binding affinity was investigated for Nefopam analogues (NFs), a functionalized benzoxazocine, with human serum albumin (HSA), a major transport protein in the blood. Its binding affinity and concomitant changes in its conformation, binding site and simulations were also studied. Fluorescence data revealed that the fluorescence quenching of HSA upon binding of NFs analogues is based on a static mechanism. The three analogues of NFs binding constants (KA) are in the order of NF3 > NF2 > NF1 with values of 1...
August 16, 2016: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/27413481/the-role-of-spinal-dopaminergic-transmission-in-the-analgesic-effect-of-nefopam-on-rat-inflammatory-pain
#12
Do Yun Kim, Joo Wung Chae, Chang Hun Lim, Bong Ha Heo, Keun Suk Park, Hyung Gon Lee, Jeong Il Choi, Myung Ha Yoon, Woong Mo Kim
BACKGROUND: Nefopam has been known as an inhibitor of the reuptake of monoamines, and the noradrenergic and/or serotonergic system has been focused on as a mechanism of its analgesic action. Here we investigated the role of the spinal dopaminergic neurotransmission in the antinociceptive effect of nefopam administered intravenously or intrathecally. METHODS: The effects of intravenously and intrathecally administered nefopam were examined using the rat formalin test...
July 2016: Korean Journal of Pain
https://www.readbyqxmd.com/read/27358262/opioid-sparing-effect-and-safety-of-nefopam-in-patient-controlled-analgesia-after-laparotomy-a-randomized-double-blind-study
#13
Hyun Seung Jin, Yong Chul Kim, Yongjae Yoo, Changsoon Lee, Chan Woo Cho, Won-Joong Kim
OBJECTIVES: A double-blind randomised study to evaluate the opioid sparing effect and safety of nefopam when administered via intravenous patient controlled analgesia (PCA) with fentanyl. METHODS: Patients planned for elective open laparotomy, were randomly assigned to receive into fentanyl 25 µg/ml (SF group) or nefopam 2.4 mg/ml plus fentanyl 25 µg/ml (NF group). Patients were assessed before surgery and for 24 h postoperatively. RESULTS: Total PCA fentanyl consumption was significantly lower in the NF group (n = 35) than the SF group (n = 36)...
August 2016: Journal of International Medical Research
https://www.readbyqxmd.com/read/27350217/nefopam-a-non-opioid-analgesic-does-not-alleviate-experimental-work-effort-dyspnoea-in-healthy-humans-a-randomised-controlled-trial
#14
Laurence Dangers, Louis Laviolette, Bény Charbit, Thomas Similowski, Capucine Morélot-Panzini
BACKGROUND: Dyspnoea is a distressing and debilitating symptom with a major impact on quality of life. Alleviation of dyspnoea therefore constitutes a major clinical challenge. When causative physiological disorders cannot be corrected ("persistent dyspnoea"), nonspecific treatment must be considered. Morphine alleviates dyspnoea but has numerous side-effects including ventilatory depression, which justifies looking for alternatives. Certain forms of dyspnoea involve C-fibres, and can be attenuated by C-fibres blockade...
August 2016: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27224932/the-antiallodynic-effects-of-nefopam-are-mediated-by-the-adenosine-triphosphate-sensitive-potassium-channel-in-a-neuropathic-pain-model
#15
Won Uk Koh, Jin Woo Shin, Ji-Yeon Bang, Sae Gyeol Kim, Jun-Gol Song
BACKGROUND: Nefopam hydrochloride is a centrally acting compound that induces antinociceptive and antihyperalgesic properties in neuropathic pain models. Previous reports have shown that activation of adenosine triphosphate (ATP)-sensitive and calcium-activated potassium (KATP and KCa2+) channels has antiallodynic effects in neuropathic pain. In the present study, we evaluated the relationship between potassium channels and nefopam to determine whether the antiallodynic effects of nefopam are mediated by potassium channels in a neuropathic pain model...
September 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27196485/preventive-analgesic-efficacy-of-nefopam-in-acute-and-chronic-pain-after-breast-cancer-surgery-a-prospective-double-blind-and-randomized-trial
#16
RANDOMIZED CONTROLLED TRIAL
Hyo-Seok Na, Ah-Young Oh, Bon-Wook Koo, Dae-Jin Lim, Jung-Hee Ryu, Ji-Won Han
Breast cancer surgery is known to cause severe acute postoperative pain, which can persist for a long time. We administered nefopam preventively to patients undergoing lumpectomy with axillary lymph node dissection or sentinel lymph node biopsy, and evaluated its efficacy on acute and chronic postoperative pain.Enrolled patients were assigned to the nefopam (n = 41) or the control (n = 42) group. Before initiating the operation, 20 mg of nefopam was given to the patients of the nefopam group, and normal saline was used in the control group...
May 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27103966/the-effect-of-nefopam-on-postoperative-fentanyl-consumption-a-randomized-double-blind-study
#17
Jee Youn Moon, Sang Sik Choi, Shin Young Lee, Mi Kyung Lee, Jung Eun Kim, Ji Eun Lee, So Hyun Lee
BACKGROUND: Nefopam is a non-opioid, non-steroidal, centrally acting analgesic drug. The concomitant use of opioids and nefopam is believed to have many advantages over the administration of opioids alone for postoperative pain management. We conducted a randomized, double-blind study to determine the fentanyl-sparing effect of co-administration of nefopam with fentanyl for postoperative pain management via patient controlled analgesia (PCA). METHODS: Ninety female patients who underwent laparoscopic total hysterectomy under general anesthesia were randomized into 3 groups, Group A, fentanyl 1,000 µg; Group B, fentanyl 500 µg + nefopam 200 mg; and Group C, fentanyl 500 µg + nefopam 400 mg, in a total volume of 100 ml PCA to be administered over the first 48 h postoperatively without basal infusion...
April 2016: Korean Journal of Pain
https://www.readbyqxmd.com/read/27103960/use-of-nefopam-in-perioperative-pain-management-keeping-nefopam-in-between
#18
Jeong Il Choi
No abstract text is available yet for this article.
April 2016: Korean Journal of Pain
https://www.readbyqxmd.com/read/27066208/post-operative-intravenous-patient-controlled-analgesic-efficacy-of-morphine-with-ketorolac-versus-nefopam-after-laparoscopic-gynecologic-surgery-a-randomized-non-inferiority-trial
#19
Ji-Uk Yoon, Gyeong-Jo Byeon, Ji-Hyun Cheon, Yoon-Mi Choi, Hyun-Su Ri, Seong-Wan Baik
BACKGROUND: Nefopam is a non-opioid non-steroidal centrally acting analgesic. This study was conducted to assess the analgesic efficacy of intravenous patient-controlled analgesia (IV-PCA) using nefopam alone, compared with a combination of morphine and ketorolac, after laparoscopic gynecologic surgery. METHODS: Sixty patients undergoing laparoscopic gynecologic surgery received IV-PCA. Group A (n = 30) received IV-PCA with a combination of morphine 60 mg and ketorolac 180 mg, while group B (n = 30) received nefopam 200 mg (basal rate 1 ml/h, bolus 1 ml, and lockout time 15 min for both)...
April 2016: Korean Journal of Anesthesiology
https://www.readbyqxmd.com/read/27025133/-opioid-free-anesthesia-analgesia-and-sedation-in-surgery-of-head-and-neck-tumor
#20
V V Balandin, E S Gorobec
62 adult patients had highly traumatic cancer head and neck surgery under multimodal non-opioid general anesthesia consisted of dexmedetomidine, lidocane, nefopam and sevoflurane. 18 patients had been intubatedwith fiber optic bronchoscope because of II-IV grade trismus. 10 patients with laryngeal stenosis had been tracheotomizedfor intubation. All these 28 patients had been sedated with dexmedetomidine, lidocane and small doses (10-20 mg) ketamine additionally to local anesthesia. All these patients maintained consciousness and breathed spontaneously...
November 2015: Anesteziologiia i Reanimatologiia
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