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https://www.readbyqxmd.com/read/28927084/thalidomide-and-lenalidomide-for-recurrent-ovarian-cancer-a-systematic-review-of-the-literature
#1
Clemens B Tempfer, Beate Schultheis, Ziad Hilal, Askin Dogan, Günther A Rezniczek
The present review aimed to assess the safety and efficacy of thalidomide and lenalidomide, two immunomodulatory drugs with anti-angiogenic properties, in women with recurrent ovarian, fallopian tube, and primary peritoneal cancer. A systematic review of the literature was conducted whereby Medline and the Cochrane Central Register of Controlled Trials were searched using terms associated with thalidomide, lenalidomide, and recurrent ovarian, fallopian tube and primary peritoneal cancer. Published English language case reports, trials and studies that described the safety and efficacy of thalidomide or lenalidomide alone, or in combination with other drugs were reviewed...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28926417/the-reading-the-mind-in-the-eyes-test-validity-and-reliability-of-the-thai-version
#2
Thammanard Charernboon, Tiraya Lerthattasilp
BACKGROUND AND OBJECTIVE: Until now there has not been a validated measure of theory of mind available in the Thai language. Our goal in this study was to assess the validity and reliability of our Thai-language translation of the Reading the Mind in the Eyes Test (the "Eyes Test"). METHODS: We gave our Thai version of the Eyes Test to 70 participants: 30 people with schizophrenia and 40 normal controls. We also gave Thai versions of the Faces Test and the Addenbrooke's Cognitive Examination to assess convergent validity...
September 2017: Cognitive and Behavioral Neurology: Official Journal of the Society for Behavioral and Cognitive Neurology
https://www.readbyqxmd.com/read/28926388/opportunistic-use-of-ct-imaging-for-osteoporosis-screening-and-bone-density-assessment-a-qualitative-systematic-review
#3
Elizabeth B Gausden, Benedict U Nwachukwu, Joseph J Schreiber, Dean G Lorich, Joseph M Lane
BACKGROUND: The purpose of this study was to determine the clinical opportunities for the use of computed tomography (CT) imaging for inferring bone quality and to critically analyze the correlation between dual x-ray absorptiometry (DXA) and diagnostic CT as reported in the literature. METHODS: A systematic review of the MEDLINE database was performed in February 2016 using the PubMed interface. The inclusion criteria were English language, studies performed using living human subjects, studies pertaining to orthopaedics, use of conventional diagnostic CT scans, studies that measured cancellous bone, and studies that reported Hounsfield unit (HU) measurements directly rather than a computed bone mineral density...
September 20, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28925580/nutrition-hygiene-and-stimulation-education-to-improve-growth-cognitive-language-and-motor-development-among-infants-in-uganda-a-cluster-randomized-trial
#4
Grace K M Muhoozi, Prudence Atukunda, Lien M Diep, Robert Mwadime, Archileo N Kaaya, Anne B Skaare, Tiril Willumsen, Ane C Westerberg, Per O Iversen
Stunting is associated with impaired cognitive and motor function. The effect of an education intervention including nutrition, stimulation, sanitation, and hygiene on child growth and cognitive/language/motor development, delivered to impoverished mothers in Uganda, was assessed. In a community-based, open cluster-randomized trial, 511 mother/children dyads aged 6-8 months were enrolled to an intervention (n = 263) or control (n = 248) group. The primary outcome was change in length-for-age z-score at age 20-24 months...
September 19, 2017: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/28925538/maternal-intelligence-quotient-iq-predicts-iq-and-language-in-very-preterm-children-at-age-5%C3%A2-years
#5
Rachel E Lean, Rachel A Paul, Christopher D Smyser, Cynthia E Rogers
BACKGROUND: Sociodemographic factors are linked to cognitive outcomes in children born very preterm (VPT; ≤30 weeks gestation). The influence of maternal intellectual ability, a heritable trait, is unknown. Also undetermined is the extent to which associations between maternal and child intellectual ability vary according to parenting behaviors that target cognitive stimulation in the home. METHODS: At age 5 years, 84 VPT and 38 demographically matched full-term (FT) children underwent neurodevelopmental assessment...
September 19, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28925287/assessing-and-developing-the-written-reflective-practice-skills-of-speech-language-pathology-students
#6
Kate Cook, Gina Tillard, Christine Wyles, Daniel Gerhard, Tika Ormond, Megan McAuliffe
PURPOSE: Written reflective practice aims to support critical thinking and problem solving skills in speech-language pathology (SLP) clinical education programmes. Yet, there has been limited investigation of students' development of written reflective practice skills over time and during a real-time clinical experience. The purpose of this study was to investigate students' development of breadth and depth of written reflective practice across a six-week clinical experience. METHOD: Participants were 59 undergraduate and 14 postgraduate SLP students...
September 19, 2017: International Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/28924555/early-changes-in-brain-structure-correlate-with-language-outcomes-in-children-with-neonatal-encephalopathy
#7
Kevin A Shapiro, Hosung Kim, Maria Luisa Mandelli, Elizabeth E Rogers, Dawn Gano, Donna M Ferriero, A James Barkovich, Maria Luisa Gorno-Tempini, Hannah C Glass, Duan Xu
Global patterns of brain injury correlate with motor, cognitive, and language outcomes in survivors of neonatal encephalopathy (NE). However, it is still unclear whether local changes in brain structure predict specific deficits. We therefore examined whether differences in brain structure at 6 months of age are associated with neurodevelopmental outcomes in this population. We enrolled 32 children with NE, performed structural brain MR imaging at 6 months, and assessed neurodevelopmental outcomes at 30 months...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28924020/microindentation-a-tool-for-measuring-cortical-bone-stiffness-a-systematic-review
#8
M Arnold, S Zhao, S Ma, F Giuliani, U Hansen, J P Cobb, R L Abel, O Boughton
OBJECTIVES: Microindentation has the potential to measure the stiffness of an individual patient's bone. Bone stiffness plays a crucial role in the press-fit stability of orthopaedic implants. Arming surgeons with accurate bone stiffness information may reduce surgical complications including periprosthetic fractures. The question addressed with this systematic review is whether microindentation can accurately measure cortical bone stiffness. METHODS: A systematic review of all English language articles using a keyword search was undertaken using Medline, Embase, PubMed, Scopus and Cochrane databases...
September 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28923594/working-memory-predicts-children-s-analogical-reasoning
#9
Nina K Simms, Rebecca R Frausel, Lindsey E Richland
Analogical reasoning is the cognitive skill of drawing relationships between representations, often between prior knowledge and new representations, that allows for bootstrapping cognitive and language development. Analogical reasoning proficiency develops substantially during childhood, although the mechanisms underlying this development have been debated, with developing cognitive resources as one proposed mechanism. We explored the role of executive function (EF) in supporting children's analogical reasoning development, with the goal of determining whether predicted aspects of EF were related to analogical development at the level of individual differences...
September 15, 2017: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/28923499/descemet-membrane-endothelial-keratoplasty-safety-and-outcomes-a-report-by-the-american-academy-of-ophthalmology
#10
Sophie X Deng, W Barry Lee, Kristin M Hammersmith, Anthony N Kuo, Jennifer Y Li, Joanne F Shen, Mitchell P Weikert, Roni M Shtein
PURPOSE: To review the published literature on the safety and outcomes of Descemet membrane endothelial keratoplasty (DMEK) for the surgical treatment of corneal endothelial dysfunction. METHODS: Literature searches were last conducted in the PubMed and the Cochrane Library databases most recently in May 2017. The searches, which were limited to English-language abstracts, yielded 1085 articles. The panel reviewed the abstracts, and 47 were determined to be relevant to this assessment...
September 15, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28923498/assessment-of-grammar-optimizes-language-tasks-for-the-intracarotid-amobarbital-procedure
#11
Monika Połczyńska, Taylor Kuhn, S Christine You, Patricia Walshaw, Susan Curtiss, Susan Bookheimer
PURPOSE: A previous study showed that assessment of language laterality could be improved by adding grammar tests to the recovery phase of the intracarotid amobarbital procedure (IAP) (Połczyńska et al. 2014). The aim of this study was to further investigate the extent to which grammar tests lateralize language function during the recovery phase of the IAP in a larger patient sample. METHODS: Forty patients with drug-resistant epilepsy (14 females, thirty-two right-handed, mean age 38...
September 9, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28923270/definitive-abutments-placed-at-implant-insertion-and-never-removed-is-it-an-effective-approach-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#12
REVIEW
Marco Tallarico, Martina Caneva, Silvio Mario Meloni, Erta Xhanari, Ugo Covani, Luigi Canullo
PURPOSE: To assess whether repeated abutment disconnections and reconnections have any impact on peri-implant bone resorption and soft tissue healing. MATERIALS AND METHODS: Electronic and manual searches were conducted for English-language articles published up to March 2017 that identified a relation between repeated disconnections of implant abutments (PA group) and prosthetic or implant failures, complications, marginal bone loss (MBL), soft tissue healing, and esthetic evaluation (pink esthetic score [PES]) after at least 1 year of function compared with implants receiving a final abutment at the time of implant placement (DA group)...
August 24, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28923113/chinese-version-of-the-constant-murley-questionnaire-for-shoulder-pain-and-disability-a-reliability-and-validation-study
#13
Min Yao, Long Yang, Zuo-Yuan Cao, Shao-Dan Cheng, Shuang-Lin Tian, Yue-Li Sun, Jing Wang, Bao-Ping Xu, Xiao-Chun Hu, Yong-Jun Wang, Ying Zhang, Xue-Jun Cui
BACKGROUND: Shoulder pain is a common musculoskeletal disorder in Chinese population, which affects more than 1,3 billion individuals. To the best of our knowledge, there has been no available Chinese-language version of measurements of shoulder pain and disability so far. Moreover, the Constant-Murley score (CMS) questionnaire is a universally recognized patient-reported questionnaire for clinical practice and research. The present study was designed to evaluate a Chinese translational version of CMS and subsequently assess its reliability and validity...
September 18, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28923110/development-of-an-arabic-inpatient-satisfaction-survey-application-in-acute-medical-rehabilitation-setting-in-saudi-arabia
#14
Ahmed Aboabat, Hazem Qannam
BACKGROUND: In the management of chronic disease, evidence suggests that satisfied patients exhibit more loyalty to treatment providers and greater adherence to treatment regimens. This is particularly so in the rehabilitation setting. We aimed to develop a reliable and valid Arabic-language survey to objectively measure inpatient satisfaction in medical rehabilitation settings in Saudi Arabia. METHODS: The King Fahad Medical City Rehabilitation Hospital Patient Satisfaction Survey (RH PSS) is a self-administered survey that addresses four domains of rehabilitation care: access, structure, process, and outcomes...
September 18, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28922704/direct-acting-antivirals-for-chronic-hepatitis-c
#15
REVIEW
Janus C Jakobsen, Emil Eik Nielsen, Joshua Feinberg, Kiran Kumar Katakam, Kristina Fobian, Goran Hauser, Goran Poropat, Snezana Djurisic, Karl Heinz Weiss, Milica Bjelakovic, Goran Bjelakovic, Sarah Louise Klingenberg, Jian Ping Liu, Dimitrinka Nikolova, Ronald L Koretz, Christian Gluud
BACKGROUND: Millions of people worldwide suffer from hepatitis C, which can lead to severe liver disease, liver cancer, and death. Direct-acting antivirals (DAAs), e.g. sofosbuvir, are relatively new and expensive interventions for chronic hepatitis C, and preliminary results suggest that DAAs may eradicate hepatitis C virus (HCV) from the blood (sustained virological response). Sustained virological response (SVR) is used by investigators and regulatory agencies as a surrogate outcome for morbidity and mortality, based solely on observational evidence...
September 18, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28922230/optimal-dose-of-perineural-dexamethasone-to-prolong-analgesia-after-brachial-plexus-blockade-a-systematic-review-and-meta-analysis
#16
Kyle Robert Kirkham, Alain Jacot-Guillarmod, Eric Albrecht
BACKGROUND: Perineural dexamethasone has gained popularity in regional anesthesia to prolong analgesia duration. However, uncertainty remains regarding the optimal perineural dose. Clarification of this characteristic is of significant importance as the administration of dexamethasone may lead to dose-dependent complications. The objective of this meta-analysis was to define the optimal perineural dexamethasone dose to prolong analgesia after brachial plexus blockade for adult patients undergoing upper limb surgery...
September 14, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28922153/sex-dependent-associations-of-serum-uric-acid-with-brain-function-during-aging
#17
Alexandra M Kueider, Yang An, Toshiko Tanaka, Melissa H Kitner-Triolo, Stephanie Studenski, Luigi Ferrucci, Madhav Thambisetty
Serum uric acid (SUA) is an abundant natural antioxidant which could reduce the burden of cellular oxidation, a major cause of neurodegenerative disease. In line with this, SUA levels are lower in those with Alzheimer's disease; however, the association between SUA and cognition remains unclear. Results from studies examining the effects of SUA on cognition may be difficult to interpret in the context of normal versus pathological aging. This study examined sex-specific associations of baseline SUA with cognition during aging...
September 8, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28921731/inter-observer-agreement-in-pediatric-cervical-spine-injury-assessment-between-prehospital-and-emergency-department-providers
#18
Lorin R Browne, Hamilton Schwartz, Fahd A Ahmad, Michael Wallendorf, Nathan Kuppermann, E Brooke Lerner, Julie C Leonard
BACKGROUND: Investigators have derived cervical spine injury (CSI) decision support tools from physician observations. There is a need to demonstrate that prehospital emergency medical services (EMS) providers can use these tools to appropriately determine the need for spinal motion restrictions and make field disposition decisions. OBJECTIVE: To determine the inter-observer agreement between EMS and emergency department (ED) providers for CSI risk assessment variables and overall gestalt for CSI in children after blunt trauma...
September 18, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28921543/language-growth-in-children-with-heterogeneous-language-disorders-a-population-study
#19
Courtenay Frazier Norbury, George Vamvakas, Debbie Gooch, Gillian Baird, Tony Charman, Emily Simonoff, Andrew Pickles
BACKGROUND: Language development has been characterised by significant individual stability from school entry. However, the extent to which trajectories of language growth vary in children with language disorder as a function of co-occurring developmental challenges is a question of theoretical import, with implications for service provision. METHODS: SCALES employed a population-based survey design with sample weighting procedures to estimate growth in core language skills over the first three years of school...
October 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28921487/family-support-and-gains-in-school-readiness-a-longitudinal-study
#20
Claire Hughes, Naomi White, Sarah Foley, Rory T Devine
BACKGROUND: Traditional measures of school readiness are labour-intensive and do not assess family support. AIMS: The current study used the newly developed Brief Early Skills and Support Index (BESSI: Hughes, Daly, Foley, White and Devine 2015) to examine 6-month longitudinal stability and change in teachers' ratings of young children's school readiness and investigate the role of family support as a predictor of school readiness. SAMPLE: Five hundred and seventy-eight children (270 boys; 74...
September 17, 2017: British Journal of Educational Psychology
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