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Ablation of the dorsal root ganglion

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https://www.readbyqxmd.com/read/27321926/tentonin-3-tmem150c-confers-distinct-mechanosensitive-currents-in-dorsal-root-ganglion-neurons-with-proprioceptive-function
#1
Gyu-Sang Hong, Byeongjun Lee, Jungwon Wee, Hyeyeon Chun, Hyungsup Kim, Jooyoung Jung, Joo Young Cha, Tae-Ryong Riew, Gyu Hyun Kim, In-Beom Kim, Uhtaek Oh
Touch sensation or proprioception requires the transduction of mechanical stimuli into electrical signals by mechanoreceptors in the periphery. These mechanoreceptors are equipped with various transducer channels. Although Piezo1 and 2 are mechanically activated (MA) channels with rapid inactivation, MA molecules with other inactivation kinetics have not been identified. Here we report that heterologously expressed Tentonin3 (TTN3)/TMEM150C is activated by mechanical stimuli with distinctly slow inactivation kinetics...
July 6, 2016: Neuron
https://www.readbyqxmd.com/read/27224659/the-dorsal-root-ganglion-as-a-therapeutic-target-for-chronic-pain
#2
Liong Liem, Eric van Dongen, Frank J Huygen, Peter Staats, Jeff Kramer
Chronic neuropathic pain is a widespread problem with negative personal and societal consequences. Despite considerable clinical neuroscience research, the goal of developing effective, reliable, and durable treatments has remained elusive. The critical role played by the dorsal root ganglion (DRG) in the induction and maintenance of chronic pain has been largely overlooked in these efforts, however. It may be that, by targeting this site, robust new options for pain management will be revealed. This review summarizes recent advances in the knowledge base for DRG-targeted treatments for neuropathic pain:• Pharmacological options including the chemical targeting of voltage-dependent calcium channels, transient receptor potential channels, neurotrophin production, potentiation of opioid transduction pathways, and excitatory glutamate receptors...
July 2016: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/27176211/systemic-qx-314-reduces-bone-cancer-pain-through-selective-inhibition-of-transient-receptor-potential-vanilloid-subfamily-1-expressing-primary-afferents-in-mice
#3
Satoshi Fuseya, Katsumi Yamamoto, Hitoshi Minemura, Satoshi Yamaori, Tomoyuki Kawamata, Mikito Kawamata
BACKGROUND: The aim of this study was to determine whether systemic administration of QX-314 reduces bone cancer pain through selective inhibition of transient receptor potential vanilloid subfamily 1 (TRPV1)-expressing afferents. METHODS: A mouse model of bone cancer pain was used. The authors examined the effects of bolus (0.01 to 3 mg/kg, n = 6 to 10) and continuous (5 mg kg h, n = 5) administration of QX-314 on both bone cancer pain-related behaviors and phosphorylated cyclic adenosine monophosphate response element-binding protein expression in dorsal root ganglion neurons (n = 3 or 6) and the effects of ablation of TRPV1-expressing afferents on bone cancer pain-related behaviors (n = 10)...
July 2016: Anesthesiology
https://www.readbyqxmd.com/read/27076431/merkel-cell-driven-bdnf-signaling-specifies-sai-neuron-molecular-and-electrophysiological-phenotypes
#4
Erin G Reed-Geaghan, Margaret C Wright, Lauren A See, Peter C Adelman, Kuan Hsien Lee, H Richard Koerber, Stephen M Maricich
UNLABELLED: The extent to which the skin instructs peripheral somatosensory neuron maturation is unknown. We studied this question in Merkel cell-neurite complexes, where slowly adapting type I (SAI) neurons innervate skin-derived Merkel cells. Transgenic mice lacking Merkel cells had normal dorsal root ganglion (DRG) neuron numbers, but fewer DRG neurons expressed the SAI markers TrkB, TrkC, and Ret. Merkel cell ablation also decreased downstream TrkB signaling in DRGs, and altered the expression of genes associated with SAI development and function...
April 13, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/26769971/pyruvate-dehydrogenase-kinase-mediated-glycolytic-metabolic-shift-in-the-dorsal-root-ganglion-drives-painful-diabetic-neuropathy
#5
Md Habibur Rahman, Mithilesh Kumar Jha, Jong-Heon Kim, Youngpyo Nam, Maan Gee Lee, Younghoon Go, Robert A Harris, Dong Ho Park, Hyun Kook, In-Kyu Lee, Kyoungho Suk
The dorsal root ganglion (DRG) is a highly vulnerable site in diabetic neuropathy. Under diabetic conditions, the DRG is subjected to tissue ischemia or lower ambient oxygen tension that leads to aberrant metabolic functions. Metabolic dysfunctions have been documented to play a crucial role in the pathogenesis of diverse pain hypersensitivities. However, the contribution of diabetes-induced metabolic dysfunctions in the DRG to the pathogenesis of painful diabetic neuropathy remains ill-explored. In this study, we report that pyruvate dehydrogenase kinases (PDK2 and PDK4), key regulatory enzymes in glucose metabolism, mediate glycolytic metabolic shift in the DRG leading to painful diabetic neuropathy...
March 11, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/26695138/ablation-of-a-small-subpopulation-of-diabetes-specific-bone-marrow-derived-cells-in-mice-protects-against-diabetic-neuropathy
#6
Hiroshi Urabe, Tomoya Terashima, Hideto Kojima, Lawrence Chan
Diabetic peripheral neuropathy (DPN) is a major diabetic complication. Previously, we showed that hyperglycemia induces the appearance of proinsulin (PI)-producing bone marrow-derived cells (PI-BMDCs), which fuse with dorsal root ganglion neurons, causing apoptosis, nerve dysfunction, and DPN. In this study, we have devised a strategy to ablate PI-BMDCs in mice in vivo. The use of this strategy to selectively ablate TNFα-producing PI-BMDCs in diabetic mice protected these animals from developing DPN. The findings provide powerful validation for a pathogenic role of PI-BMDCs and identify PI-BMDCs as an accessible therapeutic target for the treatment and prevention of DPN...
February 15, 2016: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/26479925/inhibition-of-mechanical-allodynia-in-neuropathic-pain-by-tlr5-mediated-a-fiber-blockade
#7
Zhen-Zhong Xu, Yong Ho Kim, Sangsu Bang, Yi Zhang, Temugin Berta, Fan Wang, Seog Bae Oh, Ru-Rong Ji
Mechanical allodynia, induced by normally innocuous low-threshold mechanical stimulation, represents a cardinal feature of neuropathic pain. Blockade or ablation of high-threshold, small-diameter unmyelinated group C nerve fibers (C-fibers) has limited effects on mechanical allodynia. Although large, myelinated group A fibers, in particular Aβ-fibers, have previously been implicated in mechanical allodynia, an A-fiber-selective pharmacological blocker is still lacking. Here we report a new method for targeted silencing of A-fibers in neuropathic pain...
November 2015: Nature Medicine
https://www.readbyqxmd.com/read/26447707/roles-of-isolectin-b4-binding-afferents-in-colorectal-mechanical-nociception
#8
Jun-Ho La, Bin Feng, Kaori Kaji, Erica S Schwartz, G F Gebhart
Isolectin B4-binding (IB4+) dorsal root ganglion (DRG) neurons are distinct from peptidergic DRG neurons in their terminal location in the spinal cord and respective contributions to various classes and modalities of nociception. In DRG neurons innervating the mouse colon (c-DRG neurons), the reported proportion of IB4+ population is inconsistent across studies, and little is known regarding their role in colorectal mechanonociception. To address these issues, in C57BL/6J mice, we quantified IB4+ binding after labeling c-DRG neurons with Fast Blue and examined functional consequences of ablating these neurons by IB4-conjugated saporin...
February 2016: Pain
https://www.readbyqxmd.com/read/26384294/-ganglion-block-when-and-how
#9
R Bale
CLINICAL ISSUE: Increasing understanding of the anatomy and physiology of neural structures has led to the development of surgical and percutaneous neurodestructive methods in order to target and destroy various components of afferent nociceptive pathways. The dorsal root ganglia and in particular the ganglia of the autonomous nervous system are targets for radiological interventions. The autonomous nervous system is responsible for the regulation of organ functions, sweating, visceral and blood vessel-associated pain...
October 2015: Der Radiologe
https://www.readbyqxmd.com/read/26311188/imaging-fictive-locomotor-patterns-in-larval-drosophila
#10
Stefan R Pulver, Timothy G Bayley, Adam L Taylor, Jimena Berni, Michael Bate, Berthold Hedwig
We have established a preparation in larval Drosophila to monitor fictive locomotion simultaneously across abdominal and thoracic segments of the isolated CNS with genetically encoded Ca(2+) indicators. The Ca(2+) signals closely followed spiking activity measured electrophysiologically in nerve roots. Three motor patterns are analyzed. Two comprise waves of Ca(2+) signals that progress along the longitudinal body axis in a posterior-to-anterior or anterior-to-posterior direction. These waves had statistically indistinguishable intersegmental phase delays compared with segmental contractions during forward and backward crawling behavior, despite being ∼10 times slower...
November 2015: Journal of Neurophysiology
https://www.readbyqxmd.com/read/26240991/pain-from-intra-articular-ngf-or-joint-injury-in-the-rat-requires-contributions-from-peptidergic-joint-afferents
#11
Jeffrey V Kras, Christine L Weisshaar, Parul S Pall, Beth A Winkelstein
Non-physiological stretch of the cervical facet joint's capsular ligament induces persistent behavioral hypersensitivity and spinal neuronal hyperexcitability via an intra-articular NGF-dependent mechanism. Although that ligament is innervated by nociceptors, it is unknown if a subpopulation is exclusively responsible for the behavioral and spinal neuronal responses to intra-articular NGF and/or facet joint injury. This study ablated joint afferents using the neurotoxin saporin targeted to neurons involved in either peptidergic ([Sar(9),Met (O2)(11)]-substance P-saporin (SSP-Sap)) or non-peptidergic (isolectin B4-saporin (IB4-Sap)) signaling to investigate the contributions of those neuronal populations to facet-mediated pain...
September 14, 2015: Neuroscience Letters
https://www.readbyqxmd.com/read/25720768/treatment-of-hemicrania-continua-with-radiofrequency-ablation-and-long-term-follow-up
#12
Jennifer L Beams, Matthew T Kline, Todd D Rozen
OBJECTIVE: The objective of this research is to describe novel procedural treatments for hemicrania continua that allow patients to remain off indomethacin. METHODS: Case reports are presented. RESULTS: We describe four distinct patients with indomethacin-responsive hemicrania continua who were unable to discontinue the use of indomethacin without headache recurrence. No other medications were effective for their syndrome. Secondary causes of headache were ruled out in each case...
November 2015: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/25262523/study-of-the-damage-rate-caused-by-intervertebral-foramen-type-inside-and-outside-and-the-pass-of-the-intervertebral-drg-rf-puncture-way
#13
Jiashu Sun, Haitao Zhang
This paper was to analyze and contrast the damage rate on the thoracic segment different position of the dorsal root ganglion(dorsal root ganglion, DRG) caused by different puncture path in radiofrequency ablation, thus the best RF target way for the thoracic segment of different types of DRG was confirmed. According to the difference of puncture and ablation damage way, 14 segmental spinal specimens were randomly divided into three groups, and then conducted DRG radiofrequency damage on percutaneous puncture path according to the type of DRG position...
September 2014: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/25240663/surgical-options-for-complex-craniofacial-pain
#14
REVIEW
Mayur Sharma, Andrew Shaw, Milind Deogaonkar
Complex craniofacial pain can be a challenging condition to manage both medically and surgically, but there is a resurgence of interest in the role of neurostimulation therapy. Surgical options for complex craniofacial pain syndromes include peripheral nerve/field stimulation, ganglion stimulation, spinal cord stimulation, dorsal nerve root entry zone lesioning, motor cortex stimulation, and deep brain stimulation. Peripheral nerve/field stimulation is rapidly being explored and is preferred by both patients and surgeons...
October 2014: Neurosurgery Clinics of North America
https://www.readbyqxmd.com/read/24549959/enhanced-excitability-of-mrgpra3-and-mrgprd-positive-nociceptors-in-a-model-of-inflammatory-itch-and-pain
#15
Lintao Qu, Ni Fan, Chao Ma, Tao Wang, Liang Han, Kai Fu, Yingdi Wang, Steven G Shimada, Xinzhong Dong, Robert H LaMotte
Itch is a common symptom of diseases of the skin but can also accompany diseases of other tissues including the nervous system. Acute itch from chemicals experimentally applied to the skin is initiated and maintained by action potential activity in a subset of nociceptive neurons. But whether these pruriceptive neurons are active or might become intrinsically more excitable under the pathological conditions that produce persistent itch and nociceptive sensations in humans is largely unexplored. Recently, two distinct types of cutaneous nociceptive dorsal root ganglion neurons were identified as responding to pruritic chemicals and playing a role in itch sensation...
April 2014: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/24450308/anoctamin-1-contributes-to-inflammatory-and-nerve-injury-induced-hypersensitivity
#16
Byeongjun Lee, Hawon Cho, Jooyoung Jung, Young Duk Yang, Dong-Jin Yang, Uhtaek Oh
BACKGROUND: Various pathological conditions such as inflammation or injury can evoke pain hypersensitivity. That represents the response to innocuous stimuli or exaggerated response to noxious stimuli. The molecular mechanism based on the pain hypersensitivity is associated with changes in many of ion channels in dorsal-root ganglion (DRG) neurons. Anoctamin 1 (ANO1/TMEM16A), a Ca2+ activated chloride channel is highly visible in small DRG neurons and responds to heat. Mice with an abolished function of ANO1 in DRG neurons demonstrated attenuated pain-like behaviors when exposed to noxious heat, suggesting a role in acute thermal nociception...
2014: Molecular Pain
https://www.readbyqxmd.com/read/24433241/response-of-cervicogenic-headaches-and-occipital-neuralgia-to-radiofrequency-ablation-of-the-c2-dorsal-root-ganglion-and-or-third-occipital-nerve
#17
John F Hamer, Traci A Purath
OBJECTIVE: This article investigates the degree and duration of pain relief from cervicogenic headaches or occipital neuralgia following treatment with radiofrequency ablation of the C2 dorsal root ganglion and/or third occipital nerves. It also addresses the procedure's complication rate and patient's willingness to repeat the procedure if severe symptoms recur. METHODS: This is a single-center retrospective observational study of 40 patients with refractory cervicogenic headaches and or occipital neuralgia...
March 2014: Headache
https://www.readbyqxmd.com/read/24136284/-generation-and-characterization-of-peripheral-nerve-animal-model-of-pure-motor-sensory-nerve-fibers
#18
Jian-Ping Peng, Yu-Hui Kou, Jiu-Xu Deng, Pei-Xun Zhang, Xiao-Feng Yin, Bao-Guo Jiang
OBJECTIVE: To generate peripheral nerve animal model of pure motor nerve fibers/pure sensory nerve fibers, and identify them. METHODS: The SPF SD rats were adopted in this study, and divided into 3 groups. In group A, we ablated L2-L4 ventral roots (VRs) to generate peripheral nerve animal model of pure sensory fibers. In group B, we ablated L2-L4 dorsal root ganglions (DRGs) to generate peripheral nerve animal model of pure motor fibers. Two time end-points were set as 2 weeks and 4 weeks...
October 18, 2013: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/23551937/electroacupuncture-improves-thermal-and-mechanical-sensitivities-in-a-rat-model-of-postherpetic-neuralgia
#19
Cai-hua Wu, Zheng-tao Lv, Yin Zhao, Yan Gao, Jia-qing Li, Fang Gao, Xian-fang Meng, Bo Tian, Jing Shi, Hui-lin Pan, Man Li
BACKGROUND: Electroacupuncture (EA) is effective in relieving pain in patients with postherpetic neuralgia (PHN). However, the mechanism underlying the therapeutic effect of EA in PHN is still unclear. Systemic injection of resiniferatoxin (RTX), an ultrapotent analog of TRPV1 agonist, in adult rats can reproduce the clinical symptoms of PHN by ablating TRPV1-expressing sensory neurons. In this study, we determined the beneficial effect of EA and the potential mechanisms in this rat model of PHN...
2013: Molecular Pain
https://www.readbyqxmd.com/read/23433317/the-yin-and-yang-of-pain-variability-in-formalin-test-nociception-and-morphine-analgesia-produced-by-the-yin-yang-1-transcription-factor-gene
#20
R E Sorge, M L LaCroix-Fralish, A H Tuttle, A Khoutorsky, S G Sotocinal, J-S Austin, K Melmed, S Labialle, J V Schmidt, J N Wood, A K Naumova, J S Mogil
We recently observed a reliable phenotypic difference in the inflammatory pain sensitivity of a congenic mouse strain compared to its background strain. By constructing and testing subcongenic strains combined with gene-expression assays, we provide evidence for the candidacy of the Yy1 gene - encoding the ubiquitously expressed and multifunctional Yin Yang 1 transcription factor - as responsible. To confirm this hypothesis, we used a Cre/lox strategy to produce mutant mice in which Yy1 expression was ablated in Nav 1...
June 2013: Genes, Brain, and Behavior
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