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Neurotrophin production

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https://www.readbyqxmd.com/read/27878554/the-involvement-of-the-decrease-of-astrocytic-wnt5a-in-the-cognitive-decline-in-minimal-hepatic-encephalopathy
#1
Saidan Ding, Zhu Xu, Jianjing Yang, Leping Liu, Xueli Huang, Xuebao Wang, Qichuan Zhuge
Wnt signaling plays a key role in neuroprotection and synaptic plasticity. We speculate that the impairment of Wnt signaling may mediate astrocytic neurotrophins (NTs) production and the impairment of Wnt signaling to astrocytic NTs production contributes to the pathogenesis of minimal hepatic encephalopathy (MHE). Here, we found that induction of astrocytic NTs synthesis was by Wnt5a via the calcium/calmodulin-sensitive protein kinase II (CaMK II)-cAMP-response element-binding protein (CREB) pathway in PCAs...
November 22, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27876366/leishmania-amazonensis-infection-induces-behavioral-alterations-and-modulates-cytokine-and-neurotrophin-production-in-the-murine-cerebral-cortex
#2
Alex Portes, Elizabeth Giestal-de-Araujo, Aline Fagundes, Pablo Pandolfo, Arnaldo de Sá Geraldo, Marie Luce Flores Lira, Veronica Figueiredo Amaral, Jussara Lagrota-Candido
Neurological symptoms have been associated with Leishmania infection, however little is known about how the nervous system is affected in leishmaniasis. This work aimed to analyze parasitic load, production of cytokines/neurotrophins in the prefrontal cortex and behavioral changes in BALB/c mice infected with Leishmania amazonensis. At 2 and 4months post-infection, infected mice showed a decrease in IFN-γ, IL-1, IL-6, IL-4, IL-10 cytokines and BDNF and NGF neurotrophins in prefrontal cortex associated with increased anxiety behavior...
November 12, 2016: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/27866042/carcinogenic-effects-of-oil-dispersants-a-kegg-pathway-based-rna-seq-study-of-human-airway-epithelial-cells
#3
Yao-Zhong Liu, Lei Zhang, Astrid M Roy-Engel, Shigeki Saito, Joseph A Lasky, Guangdi Wang, He Wang
The health impacts of the BP oil spill are yet to be further revealed as the toxicological effects of oil products and dispersants on human respiratory system may be latent and complex, and hence difficult to study and follow up. Here we performed RNA-seq analyses of a system of human airway epithelial cells treated with the BP crude oil and/or dispersants Corexit 9500 and Corexit 9527 that were used to help break up the oil spill. Based on the RNA-seq data, we then systemically analyzed the transcriptomic perturbations of the cells at the KEGG pathway level using two pathway-based analysis tools, GAGE (generally applicable gene set enrichment) and GSNCA (Gene Sets Net Correlations Analysis)...
November 16, 2016: Gene
https://www.readbyqxmd.com/read/27813712/optimization-of-recombinant-%C3%AE-ngf-expression-in-e-coli-using-response-surface-methodology
#4
Pouria Gholami Tilko, Zahra Hajihassan, Hamid Moghimi
Human nerve growth factor (hNGF) a member of the neurotrophin family can be used to treat neurodegenerative diseases. As it has disulfide bonds in its structure, periplasmic expression of it using appropriate signal sequence is beneficial. Therefore, in this work β-NGF was expressed in E. coli using pET39b expression vector containing dsbA signal sequence. In an initial step, the effect of IPTG and lactose concentration as inducer on protein production was investigated using response surface methodology (RSM)...
November 4, 2016: Preparative Biochemistry & Biotechnology
https://www.readbyqxmd.com/read/27804259/neuromodulation-by-cerebrovasculature-bdnf-is-it-much-greater-than-we-think
#5
EDITORIAL
C Joakim Ek
The findings published by Monnier et al. (2016) in this journal showing substantial cerebrovascular BDNF synthesis are very interesting and could change our way we perceive BDNF production in the brain under normal and disease states. BDNF is one of the classic neurotrophins first discovered in the 1950s and acts on TrkB and pan75 neurotrophin receptor (p75(NTR) ) receptors. TrkB-signalling leads to increased proliferation and survival, whereas p75(NTR) -signalling is less clear but has mostly been associated with cell damage and apoptosis (Ibanez and Simi, 2012)...
November 2, 2016: Acta Physiologica
https://www.readbyqxmd.com/read/27736950/episomal-induced-pluripotent-stem-cells-promote-functional-recovery-of-transected-murine-peripheral-nerve
#6
Charles Yuen Yung Loh, Aline Yen Ling Wang, Huang-Kai Kao, Esteban Cardona, Sheng-Hao Chuang, Fu-Chan Wei
Traumatic peripheral nerve neurotmesis occurs frequently and functional recovery is often slow and impaired. Induced pluripotent stem cells (iPSCs) have shown much promise in recent years due to its regenerative properties similar to that of embryonic stem cells. However, the potential of iPSCs in promoting the functional recovery of a transected peripheral nerve is largely unknown. This study is the first to investigate in vivo effects of episomal iPSCs (EiPSCs) on peripheral nerve regeneration in a murine sciatic nerve transection model...
2016: PloS One
https://www.readbyqxmd.com/read/27735126/sulforaphane-epigenetically-enhances-neuronal-bdnf-expression-and-trkb-signaling-pathways
#7
Jisung Kim, Siyoung Lee, Bo-Ryoung Choi, Hee Yang, Youjin Hwang, Jung Han Yoon Park, Frank M LaFerla, Jung-Soo Han, Ki Won Lee, Jiyoung Kim
SCOPE: Brain-derived neurotrophic factor (BDNF) is a neurotrophin that supports the survival of existing neurons and encourages the growth and differentiation of new neurons and synapses. We investigated the effect of sulforaphane, a hydrolysis product of glucoraphanin present in Brassica vegetables, on neuronal BDNF expression and its synaptic signaling pathways. METHODS AND RESULTS: Mouse primary cortical neurons and a triple-transgenic mouse model of Alzheimer's disease (3 × Tg-AD) were used to study the effect of sulforaphane...
October 13, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27624386/neuronal-nos-induces-neuronal-differentiation-through-a-pkc%C3%AE-dependent-gsk3%C3%AE-inactivation-pathway-in-hippocampal-neural-progenitor-cells
#8
Shin-Young Park, Min-Jeong Kang, Joong-Soo Han
We investigated the role of neuronal nitric oxide synthase (nNOS) in the neuronal differentiation of neural progenitor cells (NPCs) from hippocampi of E16.5 rat embryos. The production of nitric oxide (NO) and nNOS expression increased markedly during neuronal differentiation as did the expression of neurotrophin-3 (NT3), neurotrophin-4/5 (NT 4/5), and synapsin I. nNOS siRNA or the nNOS inhibitor, 7-nitroindazole (7-NI), decreased expression of the neurotrophins and synapsin I, and suppressed neurite outgrowth...
September 13, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27579744/atopic-dermatitis-allergic-dermatitis-or-neuroimmune-dermatitis
#9
Neide Kalil Gaspar, Márcia Kalil Aidé
Advances in knowledge of neurocellulars relations have provided new directions in the understanding and treatment of numerous conditions, including atopic dermatitis. It is known that emotional, physical, chemical or biological stimuli can generate more accentuated responses in atopic patients than in non-atopic individuals; however, the complex network of control covered by these influences, especially by neuropeptides and neurotrophins, and their genetic relations, still keep secrets to be revealed. Itching and airway hyperresponsiveness, the main aspects of atopy, are associated with disruption of the neurosensory network activity...
July 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/27519317/localization-of-trkb-and-p75-receptors-in-peritoneal-and-deep-infiltrating-endometriosis-an-immunohistochemical-study
#10
Agung Dewanto, Jozsef Dudas, Rudolf Glueckert, Sylvia Mechsner, Anneliese Schrott-Fischer, Ludwig Wildt, Beata Seeber
BACKGROUND: The roles of the neurotrophins NGF (Neurotrophic growth factor) and BDNF (brain-derived neurotrophic factor) in neuronal growth and development are already known. Meanwhile, the neurotrophin receptors TrkA (tropomyosin related kinase A), TrkB, and p75 are important for determining the fate of cells. In endometriosis, this complex system has not been fully elucidated yet. The aim of this study was to evaluate the expression and location of these neurotrophins and their receptors in peritoneal (PE) and deep infiltrating endometriotic (DIE) tissues and to measure and compare the density of nerve fibers in the disease subtypes...
2016: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/27508959/brain-derived-neurotrophic-factor-a-mediator-of-inflammation-associated-neurogenesis-in-alzheimer-s-disease
#11
Jian-Jiao Chen, Tao Wang, Cai-di An, Chun-Yan Jiang, Jie Zhao, Shao Li
In early- or late-onset Alzheimer's disease (AD), inflammation, which is triggered by pathologic conditions, influences the progression of neurodegeneration. Brain-derived neurotrophic factor (BDNF) has emerged as a crucial mediator of neurogenesis, because it exhibits a remarkable activity-dependent regulation of expression, which suggests that it may link inflammation to neurogenesis. Emerging evidence suggests that acute and chronic inflammation in AD differentially modulates neurotrophin functions, which are related to the roles of inflammation in neuroprotection and neurodegeneration...
December 1, 2016: Reviews in the Neurosciences
https://www.readbyqxmd.com/read/27484434/exercise-induced-hypoalgesia-potential-mechanisms-in-animal-models-of-neuropathic-pain
#12
Katsuya Kami, Fumihiro Tajima, Emiko Senba
Physical exercise, such as forced treadmill running and swimming, can sufficiently improve mechanical allodynia and heat hyperalgesia in animal models of neuropathic pain (NPP), including partial sciatic nerve ligation, chronic constriction injury, and spinal nerve ligation models. Thus, physical exercise has been established as a low-cost, safe, and effective way to manage NPP conditions, but the exact mechanisms underlying such exercise-induced hypoalgesia (EIH) are not fully understood. A growing body of evidence has identified several factors that work at different levels of the nervous system as playing important roles in producing EIH in animal models of NPP...
August 2, 2016: Anatomical Science International
https://www.readbyqxmd.com/read/27468425/measurement-of-inositol-triphosphate-levels-from-rat-hippocampal-slices
#13
Nino Tabatadze, Catherine Woolley
Inositol triphosphate (IP3) is an important second messenger that participates in signal transduction pathways in diverse cell types including hippocampal neurons. Stimulation of phospholipase C in response to various stimuli (hormones, growth factors, neurotransmitters, neurotrophins, neuromodulators, odorants, light, etc) results in hydrolysis of phosphatidylinositol 4, 5-bisphosphate (PIP2), a phospholipid that is located in the plasma membrane, and leads to the production of IP3 and diacylglycerol. Binding of IP3 to the IP3 receptor (IP3R) induces Ca(2+) release from intracellular stores and enables the initiation of intracellular Ca(2+)-dependent signaling...
April 5, 2016: Bio-protocol
https://www.readbyqxmd.com/read/27437725/nerve-growth-factor-promotes-expression-of-costimulatory-molecules-and-release-of-cytokines-in-dendritic-cells-involved-in-th2-response-through-lps-induced-p75ntr
#14
Hongyi Tan, Pinhua Pan, Lemeng Zhang, Zu Cao, Ben Liu, Haitao Li, Xiaoli Su
INTRODUCTION: Nerve growth factor (NGF) plays an important role in asthmatic inflammatory responses. However, the effects of NGF on dendritic cells (DCs) in asthmatic inflammation remain unknown. Therefore, we examined the effects of NGF on co-stimulatory molecules and the release of cytokines after ovalbumin (OVA) and a low dose of LPS (low LPS) stimulation of dendritic cells. METHODS: Bone-marrow-derived dendritic cells (BMDCs) were collected from 6- to 8-week-old wide or TLR4(-/-) mice...
December 2016: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/27425886/brain-derived-neurotrophic-factor-in-mood-disorders-and-antidepressant-treatments
#15
Eero Castrén, Masami Kojima
Levels of brain-derived neurotrophic factor (BDNF) are reduced in the brain and serum of depressed patients and at least the reduction in serum levels is reversible upon successful treatment. These data, together with a wealth of reports using different animal models with depression-like behavior or manipulation of expression of BDNF or its receptor TrkB have implicated BDNF in the pathophysiology of depression as well as in the mechanism of action of antidepressant treatments. Recent findings have shown that posttranslational processing of BDNF gene product can yield different molecular entities that differently influence signaling through BNDF receptor TrkB and the pan-neurotrophin receptor p75(NTR)...
July 15, 2016: Neurobiology of Disease
https://www.readbyqxmd.com/read/27423610/canine-olfactory-ensheathing-cells-from-the-olfactory-mucosa-can-be-engineered-to-produce-active-chondroitinase-abc
#16
Darren Carwardine, Liang-Fong Wong, James W Fawcett, Elizabeth M Muir, Nicolas Granger
A multitude of factors must be overcome following spinal cord injury (SCI) in order to achieve clinical improvement in patients. It is thought that by combining promising therapies these diverse factors could be combatted with the aim of producing an overall improvement in function. Chondroitin sulphate proteoglycans (CSPGs) present in the glial scar that forms following SCI present a significant block to axon regeneration. Digestion of CSPGs by chondroitinase ABC (ChABC) leads to axon regeneration, neuronal plasticity and functional improvement in preclinical models of SCI...
August 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27422411/transcriptomic-profiling-discloses-molecular-and-cellular-events-related-to-neuronal-differentiation-in-sh-sy5y-neuroblastoma-cells
#17
Francesco Pezzini, Laura Bettinetti, Francesca Di Leva, Marzia Bianchi, Elisa Zoratti, Rosalba Carrozzo, Filippo M Santorelli, Massimo Delledonne, Maciej Lalowski, Alessandro Simonati
Human SH-SY5Y neuroblastoma cells are widely utilized in in vitro studies to dissect out pathogenetic mechanisms of neurodegenerative disorders. These cells are considered as neuronal precursors and differentiate into more mature neuronal phenotypes under selected growth conditions. In this study, in order to decipher the pathways and cellular processes underlying neuroblastoma cell differentiation in vitro, we performed systematic transcriptomic (RNA-seq) and bioinformatic analysis of SH-SY5Y cells differentiated according to a two-step paradigm: retinoic acid treatment followed by enriched neurobasal medium...
July 15, 2016: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/27418434/venomics-of-calloselasma-rhodostoma-the-malayan-pit-viper-a-complex-toxin-arsenal-unraveled
#18
Esther Lai Har Tang, Choo Hock Tan, Shin Yee Fung, Nget Hong Tan
UNLABELLED: The venom of Malayan pit viper (Calloselasma rhodostoma) is highly toxic but also valuable in drug discovery. However, a comprehensive proteome of the venom that details its toxin composition and abundance is lacking. This study aimed to unravel the venom complexity through a multi-step venomic approach. At least 96 distinct proteins (29 basic, 67 acidic) in 11 families were identified from the venom. The venom consists of mainly snake venom metalloproteinases (SVMP, 41.17% of total venom proteins), within which the P-I (kistomin, 20...
October 4, 2016: Journal of Proteomics
https://www.readbyqxmd.com/read/27411106/antenatal-steroid-exposure-in-the-late-preterm-period-is-associated-with-reduced-cord-blood-neurotrophin-3
#19
Nicolette A Hodyl, Tara M Crawford, Lorna McKerracher, Andrew Lawrence, Julia B Pitcher, Michael J Stark
BACKGROUND: Neurotrophins are proteins critically involved in neural growth, survival and differentiation, and therefore important for fetal brain development. Reduced cord blood neurotrophins have been observed in very preterm infants (<32weeks gestation) who subsequently develop brain injury. Antenatal steroid exposure can alter neurotrophin concentrations, yet studies to date have not examined whether this occurs in the late preterm infant (33-36weeks gestation), despite increasing recognition of subtle neurodevelopmental deficits in this population...
October 2016: Early Human Development
https://www.readbyqxmd.com/read/27364353/long-term-production-of-bdnf-and-nt-3-induced-by-a91-immunization-after-spinal-cord-injury
#20
Susana Martiñón, Elisa García-Vences, Diana Toscano-Tejeida, Adrian Flores-Romero, Roxana Rodriguez-Barrera, Manuel Ferrusquia, Rolando E Hernández-Muñoz, Antonio Ibarra
BACKGROUND: After spinal cord (SC)-injury, a non-modulated immune response contributes to the damage of neural tissue. Protective autoimmunity (PA) is a T cell mediated, neuroprotective response induced after SC-injury. Immunization with neural-derived peptides (INDP), such as A91, has shown to promote-in vitro-the production of neurotrophic factors. However, the production of these molecules has not been studied at the site of injury. RESULTS: In order to evaluate these issues, we performed four experiments in adult female Sprague-Dawley rats...
2016: BMC Neuroscience
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