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Neurotrophin production

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https://www.readbyqxmd.com/read/28327516/an-extract-from-shrimp-processing-by-products-protects-sh-sy5y-cells-from-neurotoxicity-induced-by-a%C3%AE-25-35
#1
Yongping Zhang, Guangling Jiao, Cai Song, Shelly Gu, Richard E Brown, Junzeng Zhang, Pingcheng Zhang, Jacques Gagnon, Steven Locke, Roumiana Stefanova, Claude Pelletier, Yi Zhang, Hongyu Lu
Increased evidence suggests that marine unsaturated fatty acids (FAs) can protect neurons from amyloid-β (Aβ)-induced neurodegeneration. Nuclear magnetic resonance (NMR), high performance liquid chromatography (HPLC) and gas chromatography (GC) assays showed that the acetone extract 4-2A obtained from shrimp Pandalus borealis industry processing wastes contained 67.19% monounsaturated FAs and 16.84% polyunsaturated FAs. The present study evaluated the anti-oxidative and anti-inflammatory effects of 4-2A in Aβ25-35-insulted differentiated SH-SY5Y cells...
March 22, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28324222/bdnf-mrna-splice-variants-differentially-impact-ca1-and-ca3-dendrite-complexity-and-spine-morphology-in-the-hippocampus
#2
Kristen R Maynard, John W Hobbs, Mahima Sukumar, Alisha S Kardian, Dennisse V Jimenez, Robert J Schloesser, Keri Martinowich
Brain-derived neurotrophic factor (BDNF) is an activity-dependent neurotrophin critical for neuronal plasticity in the hippocampus. BDNF is encoded by multiple transcripts with alternative 5' untranslated regions (5'UTRS) that display activity-induced targeting to distinct subcellular compartments. While individual Bdnf 5'UTR transcripts influence dendrite morphology in cultured hippocampal neurons, it is unknown whether Bdnf splice variants impact dendrite arborization in functional classes of neurons in the intact hippocampus...
March 21, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28306638/the-proinflammatory-cytokines-il-1%C3%A3-and-tnf-%C3%AE-influence-human-annulus-cell-signaling-cues-for-neurite-growth-in-vitro-co-culture-studies
#3
Helen E Gruber, Brittany Jones, Emilio Marrero, Edward N Hanley
STUDY DESIGN: IRB-approved research using human annulus cells co-cultured with F11 nerve cells. OBJECTIVE: To perform functional, kinetic assays of neurite dynamics and media neurotrophin measurement to test whether proinflammatory cytokines influence annulus cells' signaling cues for neurite growth/repulsion. SUMMARY OF BACKGROUND DATA: Nerves grow in response to signaling molecules called neurotrophins which disc cells produce (e.g. brain-derived neurotrophic factor (BDNF), glial cell-line derived neurotrophic factor (GDNF) and neurotrophin 3 (NT3)) and which influence neuron survival, differentiation and migration...
March 16, 2017: Spine
https://www.readbyqxmd.com/read/28264445/equol-a-dietary-daidzein-gut-metabolite-attenuates-microglial-activation-and-potentiates-neuroprotection-in-vitro
#4
Lalita Subedi, Eunhee Ji, Dongyun Shin, Jongsik Jin, Joo Hong Yeo, Sun Yeou Kim
Estrogen deficiency has been well characterized in inflammatory disorders including neuroinflammation. Daidzein, a dietary alternative phytoestrogen found in soy (Glycine max) as primary isoflavones, possess anti-inflammatory activity, but the effect of its active metabolite Equol (7-hydroxy-3-(4'-hydroxyphenyl)-chroman) has not been well established. In this study, we investigated the anti-neuroinflammatory and neuroprotective effect of Equol in vitro. To evaluate the potential effects of Equol, three major types of central nervous system (CNS) cells, including microglia (BV-2), astrocytes (C6), and neurons (N2a), were used...
February 27, 2017: Nutrients
https://www.readbyqxmd.com/read/28254587/activity-of-human-kallikrein-related-peptidase-6-klk6-on-substrates-containing-sequences-of-basic-amino-acids-is-it-a-processing-protease
#5
Roberta N Silva, Lilian C G Oliveira, Carolina B Parise, Juliana R Oliveira, Beatrice Severino, Angela Corvino, Paola di Vaio, Piero A Temussi, Giuseppe Caliendo, Vincenzo Santagada, Luiz Juliano, Maria A Juliano
Human kallikrein 6 (KLK6) is highly expressed in the central nervous system and with elevated level in demyelinating disease. KLK6 has a very restricted specificity for arginine (R) and hydrolyses myelin basic protein, protein activator receptors and human ionotropic glutamate receptor subunits. Here we report a previously unreported activity of KLK6 on peptides containing clusters of basic amino acids, as in synthetic fluorogenic peptidyl-Arg-7-amino-4-carbamoylmethylcoumarin (peptidyl-ACC) peptides and FRET peptides in the format of Abz-peptidyl-Q-EDDnp (where Abz=ortho-aminobenzoic acid and Q-EDDnp=glutaminyl-N-(2,4-dinitrophenyl) ethylenediamine), in which pairs or sequences of basic amino acids (R or K) were introduced...
February 28, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28249734/role-of-brain-derived-neurotrophic-factor-and-nerve-growth-factor-in-the-regulation-of-neuropeptide-w-in%C3%A2-vitro-and-in%C3%A2-vivo
#6
Rikang Wang, Fengxia Yan, Rifang Liao, Pei Wan, Peter J Little, Wenhua Zheng
Nerve growth factor (NGF) and Brain-derived neurotrophic factor (BDNF) are neurotrophic factors involved in the growth, survival and functioning of neurons. In addition, a possible role of neurotrophins, particularly BDNF, in HPA axis hyperactivation has recently been proposed. Neuropeptide W (NPW) is an endogenous peptide ligand for the GPR7 and GPR8 and a stress mediator in the hypothalamus. It activates the HPA axis by working on hypothalamic corticotrophin-releasing hormone (CRH). No information is available about the interrelationships between neurotrophines like NGF/BDNF and NPW...
February 27, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28215300/the-role-of-neurotrophins-in-inflammation-and-allergy
#7
S Manti, P Brown, M K Perez, G Piedimonte
Allergic inflammation is the result of a specific pattern of cellular and humoral responses leading to the activation of the innate and adaptive immune system, which, in turn, results in physiological and structural changes affecting target tissues such as the airways and the skin. Eosinophil activation and the production of soluble mediators such as IgE antibodies are pivotal features in the pathophysiology of allergic diseases. In the past few years, however, convincing evidence has shown that neurons and other neurosensory structures are not only a target of the inflammatory process but also participate in the regulation of immune responses by actively releasing soluble mediators...
2017: Vitamins and Hormones
https://www.readbyqxmd.com/read/28215298/development-of-precision-small-molecule-proneurotrophic-therapies-for-neurodegenerative-diseases
#8
J Janssens, D Lu, B Ni, W Chadwick, S Siddiqui, A Azmi, H Etienne, A Jushaj, J van Gastel, B Martin, S Maudsley
Age-related neurodegenerative diseases, such as Alzheimer's disease, will represent one of the largest future burdens on worldwide healthcare systems due to the increasing proportion of elderly in our society. As deficiencies in neurotrophins are implicated in the pathogenesis of many age-related neurodegenerative disorders, it is reasonable to consider that global neurotrophin resistance may also become a major healthcare threat. Central nervous system networks are effectively maintained through aging by neuroprotective and neuroplasticity signaling mechanisms which are predominantly controlled by neurotrophin receptor signaling...
2017: Vitamins and Hormones
https://www.readbyqxmd.com/read/28215296/neurotrophins-in-the-brain-interaction-with-alcohol-exposure-during-development
#9
K E Boschen, A Y Klintsova
Fetal alcohol spectrum disorders (FASDs) are a result of the teratogenic effects of alcohol on the developing fetus. Decades of research examining both individuals with FASDs and animal models of developmental alcohol exposure have revealed the devastating effects of alcohol on brain structure, function, behavior, and cognition. Neurotrophic factors have an important role in guiding normal brain development and cellular plasticity in the adult brain. This chapter reviews the current literature showing that alcohol exposure during the developmental period impacts neurotrophin production and proposes avenues through which alcohol exposure and neurotrophin action might interact...
2017: Vitamins and Hormones
https://www.readbyqxmd.com/read/28188803/activation-of-the-sigma-1-receptor-by-haloperidol-metabolites-facilitates-brain-derived-neurotrophic-factor-secretion-from-human-astroglia
#10
Dhwanil A Dalwadi, Seongcheol Kim, John A Schetz
Glial cells play a critical role in neuronal support which includes the production and release of the neurotrophin brain-derived neurotrophic factor (BDNF). Activation of the sigma-1 receptor (S1R) has been shown to attenuate inflammatory stress-mediated brain injuries, and there is emerging evidence that this may involve a BDNF-dependent mechanism. In this report we studied S1R-mediated BDNF release from human astrocytic glial cells. Astrocytes express the S1R, which mediates BDNF release when stimulated with the prototypical S1R agonists 4-PPBP and (+)-SKF10047...
February 8, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28140833/nanoparticles-induced-apoptosis-of-human-airway-epithelium-is-mediated-by-prongf-p75-ntr-signaling
#11
Sreeparna Chakraborty, Vincent Castranova, Miriam K Perez, Giovanni Piedimonte
Environmental and occupational exposures to respirable ultrafine fractions of particulate matter (PM) have been implicated in the initiation and exacerbation of lung diseases. However, the precise mechanisms underlying production of cell damage and death attributed to nanoparticles (NP) on human airway epithelium are not fully understood. This study examined the role of neurotrophic pathways in NP-induced airway toxicity. Size and agglomeration of TiO2 nanoparticles (TiO2-NP) and fine (TiO2-FP) particles were measured by dynamic light scattering...
2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28077367/electroacupuncture-alleviates-the-inflammatory-response-via-effects-on-m1-and-m2-macrophages-after-spinal-cord-injury
#12
Jiagui Zhao, Rongyi Zhang, Likui Wang, Yuanhai Li
BACKGROUND: Macrophages/microglia are important effector cells at the site of spinal cord injury (SCI). M1-type macrophages facilitate innate immunity to remove foreign microbes and wound debris from the injury site. M2-type macrophages exhibit tissue repair properties and attenuate production of pro-inflammatory cytokines. Regulation of the polarisation of M1/M2 macrophages may affect the inflammatory response in SCI and may be related to neurotrophin-3 (NT-3). Electroacupuncture (EA) at GV acupuncture points can be used as an adjuvant therapy for SCI...
January 11, 2017: Acupuncture in Medicine: Journal of the British Medical Acupuncture Society
https://www.readbyqxmd.com/read/27939460/exploring-the-brain-skin-connection-leads-and-lessons-from-the-hair-follicle
#13
R Paus
Research into how the central nervous system (CNS) and the skin of mammals are physiologically connected and how this "brain-skin connection" may be therapeutically targeted in clinical medicine has witnessed a renaissance. A key element in this development has been the discovery that mammalian skin and its appendages, namely human scalp hair follicles (HFs), not only are important, long-underestimated target tissues for classical neurohormones, neurotrophins and neuropeptides, but also are eminent peripheral tissue sources for the production and/or release of these neuromediators...
October 2016: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/27878554/the-involvement-of-the-decrease-of-astrocytic-wnt5a-in-the-cognitive-decline-in-minimal-hepatic-encephalopathy
#14
Saidan Ding, Zhu Xu, Jianjing Yang, Leping Liu, Xueli Huang, Xuebao Wang, Qichuan Zhuge
Wnt signaling plays a key role in neuroprotection and synaptic plasticity. We speculate that the impairment of Wnt signaling may mediate astrocytic neurotrophins (NTs) production and the impairment of Wnt signaling to astrocytic NTs production contributes to the pathogenesis of minimal hepatic encephalopathy (MHE). Here, we found that induction of astrocytic NTs synthesis was by Wnt5a via the calcium/calmodulin-sensitive protein kinase II (CaMK II)-cAMP-response element-binding protein (CREB) pathway in PCAs...
November 22, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27876366/leishmania-amazonensis-infection-induces-behavioral-alterations-and-modulates-cytokine-and-neurotrophin-production-in-the-murine-cerebral-cortex
#15
Alex Portes, Elizabeth Giestal-de-Araujo, Aline Fagundes, Pablo Pandolfo, Arnaldo de Sá Geraldo, Marie Luce Flores Lira, Veronica Figueiredo Amaral, Jussara Lagrota-Candido
Neurological symptoms have been associated with Leishmania infection, however little is known about how the nervous system is affected in leishmaniasis. This work aimed to analyze parasitic load, production of cytokines/neurotrophins in the prefrontal cortex and behavioral changes in BALB/c mice infected with Leishmania amazonensis. At 2 and 4months post-infection, infected mice showed a decrease in IFN-γ, IL-1, IL-6, IL-4, IL-10 cytokines and BDNF and NGF neurotrophins in prefrontal cortex associated with increased anxiety behavior...
December 15, 2016: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/27866042/carcinogenic-effects-of-oil-dispersants-a-kegg-pathway-based-rna-seq-study-of-human-airway-epithelial-cells
#16
Yao-Zhong Liu, Lei Zhang, Astrid M Roy-Engel, Shigeki Saito, Joseph A Lasky, Guangdi Wang, He Wang
The health impacts of the BP oil spill are yet to be further revealed as the toxicological effects of oil products and dispersants on human respiratory system may be latent and complex, and hence difficult to study and follow up. Here we performed RNA-seq analyses of a system of human airway epithelial cells treated with the BP crude oil and/or dispersants Corexit 9500 and Corexit 9527 that were used to help break up the oil spill. Based on the RNA-seq data, we then systemically analyzed the transcriptomic perturbations of the cells at the KEGG pathway level using two pathway-based analysis tools, GAGE (generally applicable gene set enrichment) and GSNCA (Gene Sets Net Correlations Analysis)...
February 20, 2017: Gene
https://www.readbyqxmd.com/read/27813712/optimization-of-recombinant-%C3%AE-ngf-expression-in-escherichia-coli-using-response-surface-methodology
#17
Pouria Gholami Tilko, Zahra Hajihassan, Hamid Moghimi
Human nerve growth factor a member of the neurotrophin family can be used to treat neurodegenerative diseases. As it has disulfide bonds in its structure, periplasmic expression of it using appropriate signal sequence is beneficial. Therefore, in this work β-nerve growth factor (β-NGF) was expressed in Escherichia coli using pET39b expression vector containing DsbA signal sequence. In an initial step, the effect of isopropyl β-D-1-thiogalactopyranoside (IPTG) and lactose concentration as inducer on protein production was investigated using response surface methodology...
November 4, 2016: Preparative Biochemistry & Biotechnology
https://www.readbyqxmd.com/read/27804259/neuromodulation-by-cerebrovasculature-bdnf-is-it-much-greater-than-we-think
#18
EDITORIAL
C J Ek
No abstract text is available yet for this article.
November 2, 2016: Acta Physiologica
https://www.readbyqxmd.com/read/27736950/episomal-induced-pluripotent-stem-cells-promote-functional-recovery-of-transected-murine-peripheral-nerve
#19
Charles Yuen Yung Loh, Aline Yen Ling Wang, Huang-Kai Kao, Esteban Cardona, Sheng-Hao Chuang, Fu-Chan Wei
Traumatic peripheral nerve neurotmesis occurs frequently and functional recovery is often slow and impaired. Induced pluripotent stem cells (iPSCs) have shown much promise in recent years due to its regenerative properties similar to that of embryonic stem cells. However, the potential of iPSCs in promoting the functional recovery of a transected peripheral nerve is largely unknown. This study is the first to investigate in vivo effects of episomal iPSCs (EiPSCs) on peripheral nerve regeneration in a murine sciatic nerve transection model...
2016: PloS One
https://www.readbyqxmd.com/read/27735126/sulforaphane-epigenetically-enhances-neuronal-bdnf-expression-and-trkb-signaling-pathways
#20
Jisung Kim, Siyoung Lee, Bo-Ryoung Choi, Hee Yang, Youjin Hwang, Jung Han Yoon Park, Frank M LaFerla, Jung-Soo Han, Ki Won Lee, Jiyoung Kim
SCOPE: Brain-derived neurotrophic factor (BDNF) is a neurotrophin that supports the survival of existing neurons and encourages the growth and differentiation of new neurons and synapses. We investigated the effect of sulforaphane, a hydrolysis product of glucoraphanin present in Brassica vegetables, on neuronal BDNF expression and its synaptic signaling pathways. METHODS AND RESULTS: Mouse primary cortical neurons and a triple-transgenic mouse model of Alzheimer's disease (3 × Tg-AD) were used to study the effect of sulforaphane...
October 13, 2016: Molecular Nutrition & Food Research
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