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Neurotrophin production

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https://www.readbyqxmd.com/read/28188803/activation-of-the-sigma-1-receptor-by-haloperidol-metabolites-facilitates-brain-derived-neurotrophic-factor-secretion-from-human-astroglia
#1
Dhwanil A Dalwadi, Seongcheol Kim, John A Schetz
Glial cells play a critical role in neuronal support which includes the production and release of the neurotrophin brain-derived neurotrophic factor (BDNF). Activation of the sigma-1 receptor (S1R) has been shown to attenuate inflammatory stress-mediated brain injuries, and there is emerging evidence that this may involve a BDNF-dependent mechanism. In this report we studied S1R-mediated BDNF release from human astrocytic glial cells. Astrocytes express the S1R, which mediates BDNF release when stimulated with the prototypical S1R agonists 4-PPBP and (+)-SKF10047...
February 8, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28140833/nanoparticles-induced-apoptosis-of-human-airway-epithelium-is-mediated-by-prongf-p75-ntr-signaling
#2
Sreeparna Chakraborty, Vincent Castranova, Miriam K Perez, Giovanni Piedimonte
Environmental and occupational exposures to respirable ultrafine fractions of particulate matter (PM) have been implicated in the initiation and exacerbation of lung diseases. However, the precise mechanisms underlying production of cell damage and death attributed to nanoparticles (NP) on human airway epithelium are not fully understood. This study examined the role of neurotrophic pathways in NP-induced airway toxicity. Size and agglomeration of TiO2 nanoparticles (TiO2-NP) and fine (TiO2-FP) particles were measured by dynamic light scattering...
2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28077367/electroacupuncture-alleviates-the-inflammatory-response-via-effects-on-m1-and-m2-macrophages-after-spinal-cord-injury
#3
Jiagui Zhao, Rongyi Zhang, Likui Wang, Yuanhai Li
BACKGROUND: Macrophages/microglia are important effector cells at the site of spinal cord injury (SCI). M1-type macrophages facilitate innate immunity to remove foreign microbes and wound debris from the injury site. M2-type macrophages exhibit tissue repair properties and attenuate production of pro-inflammatory cytokines. Regulation of the polarisation of M1/M2 macrophages may affect the inflammatory response in SCI and may be related to neurotrophin-3 (NT-3). Electroacupuncture (EA) at GV acupuncture points can be used as an adjuvant therapy for SCI...
January 11, 2017: Acupuncture in Medicine: Journal of the British Medical Acupuncture Society
https://www.readbyqxmd.com/read/27939460/exploring-the-brain-skin-connection-leads-and-lessons-from-the-hair-follicle
#4
R Paus
Research into how the central nervous system (CNS) and the skin of mammals are physiologically connected and how this "brain-skin connection" may be therapeutically targeted in clinical medicine has witnessed a renaissance. A key element in this development has been the discovery that mammalian skin and its appendages, namely human scalp hair follicles (HFs), not only are important, long-underestimated target tissues for classical neurohormones, neurotrophins and neuropeptides, but also are eminent peripheral tissue sources for the production and/or release of these neuromediators...
October 2016: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/27878554/the-involvement-of-the-decrease-of-astrocytic-wnt5a-in-the-cognitive-decline-in-minimal-hepatic-encephalopathy
#5
Saidan Ding, Zhu Xu, Jianjing Yang, Leping Liu, Xueli Huang, Xuebao Wang, Qichuan Zhuge
Wnt signaling plays a key role in neuroprotection and synaptic plasticity. We speculate that the impairment of Wnt signaling may mediate astrocytic neurotrophins (NTs) production and the impairment of Wnt signaling to astrocytic NTs production contributes to the pathogenesis of minimal hepatic encephalopathy (MHE). Here, we found that induction of astrocytic NTs synthesis was by Wnt5a via the calcium/calmodulin-sensitive protein kinase II (CaMK II)-cAMP-response element-binding protein (CREB) pathway in PCAs...
November 22, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27876366/leishmania-amazonensis-infection-induces-behavioral-alterations-and-modulates-cytokine-and-neurotrophin-production-in-the-murine-cerebral-cortex
#6
Alex Portes, Elizabeth Giestal-de-Araujo, Aline Fagundes, Pablo Pandolfo, Arnaldo de Sá Geraldo, Marie Luce Flores Lira, Veronica Figueiredo Amaral, Jussara Lagrota-Candido
Neurological symptoms have been associated with Leishmania infection, however little is known about how the nervous system is affected in leishmaniasis. This work aimed to analyze parasitic load, production of cytokines/neurotrophins in the prefrontal cortex and behavioral changes in BALB/c mice infected with Leishmania amazonensis. At 2 and 4months post-infection, infected mice showed a decrease in IFN-γ, IL-1, IL-6, IL-4, IL-10 cytokines and BDNF and NGF neurotrophins in prefrontal cortex associated with increased anxiety behavior...
December 15, 2016: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/27866042/carcinogenic-effects-of-oil-dispersants-a-kegg-pathway-based-rna-seq-study-of-human-airway-epithelial-cells
#7
Yao-Zhong Liu, Lei Zhang, Astrid M Roy-Engel, Shigeki Saito, Joseph A Lasky, Guangdi Wang, He Wang
The health impacts of the BP oil spill are yet to be further revealed as the toxicological effects of oil products and dispersants on human respiratory system may be latent and complex, and hence difficult to study and follow up. Here we performed RNA-seq analyses of a system of human airway epithelial cells treated with the BP crude oil and/or dispersants Corexit 9500 and Corexit 9527 that were used to help break up the oil spill. Based on the RNA-seq data, we then systemically analyzed the transcriptomic perturbations of the cells at the KEGG pathway level using two pathway-based analysis tools, GAGE (generally applicable gene set enrichment) and GSNCA (Gene Sets Net Correlations Analysis)...
February 20, 2017: Gene
https://www.readbyqxmd.com/read/27813712/optimization-of-recombinant-%C3%AE-ngf-expression-in-escherichia-coli-using-response-surface-methodology
#8
Pouria Gholami Tilko, Zahra Hajihassan, Hamid Moghimi
Human nerve growth factor a member of the neurotrophin family can be used to treat neurodegenerative diseases. As it has disulfide bonds in its structure, periplasmic expression of it using appropriate signal sequence is beneficial. Therefore, in this work β-nerve growth factor (β-NGF) was expressed in Escherichia coli using pET39b expression vector containing DsbA signal sequence. In an initial step, the effect of isopropyl β-D-1-thiogalactopyranoside (IPTG) and lactose concentration as inducer on protein production was investigated using response surface methodology...
November 4, 2016: Preparative Biochemistry & Biotechnology
https://www.readbyqxmd.com/read/27804259/neuromodulation-by-cerebrovasculature-bdnf-is-it-much-greater-than-we-think
#9
EDITORIAL
C Joakim Ek
The findings published by Monnier et al. (2016) in this journal showing substantial cerebrovascular BDNF synthesis are very interesting and could change our way we perceive BDNF production in the brain under normal and disease states. BDNF is one of the classic neurotrophins first discovered in the 1950s and acts on TrkB and pan75 neurotrophin receptor (p75(NTR) ) receptors. TrkB-signalling leads to increased proliferation and survival, whereas p75(NTR) -signalling is less clear but has mostly been associated with cell damage and apoptosis (Ibanez and Simi, 2012)...
November 2, 2016: Acta Physiologica
https://www.readbyqxmd.com/read/27736950/episomal-induced-pluripotent-stem-cells-promote-functional-recovery-of-transected-murine-peripheral-nerve
#10
Charles Yuen Yung Loh, Aline Yen Ling Wang, Huang-Kai Kao, Esteban Cardona, Sheng-Hao Chuang, Fu-Chan Wei
Traumatic peripheral nerve neurotmesis occurs frequently and functional recovery is often slow and impaired. Induced pluripotent stem cells (iPSCs) have shown much promise in recent years due to its regenerative properties similar to that of embryonic stem cells. However, the potential of iPSCs in promoting the functional recovery of a transected peripheral nerve is largely unknown. This study is the first to investigate in vivo effects of episomal iPSCs (EiPSCs) on peripheral nerve regeneration in a murine sciatic nerve transection model...
2016: PloS One
https://www.readbyqxmd.com/read/27735126/sulforaphane-epigenetically-enhances-neuronal-bdnf-expression-and-trkb-signaling-pathways
#11
Jisung Kim, Siyoung Lee, Bo-Ryoung Choi, Hee Yang, Youjin Hwang, Jung Han Yoon Park, Frank M LaFerla, Jung-Soo Han, Ki Won Lee, Jiyoung Kim
SCOPE: Brain-derived neurotrophic factor (BDNF) is a neurotrophin that supports the survival of existing neurons and encourages the growth and differentiation of new neurons and synapses. We investigated the effect of sulforaphane, a hydrolysis product of glucoraphanin present in Brassica vegetables, on neuronal BDNF expression and its synaptic signaling pathways. METHODS AND RESULTS: Mouse primary cortical neurons and a triple-transgenic mouse model of Alzheimer's disease (3 × Tg-AD) were used to study the effect of sulforaphane...
October 13, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27624386/neuronal-nos-induces-neuronal-differentiation-through-a-pkc%C3%AE-dependent-gsk3%C3%AE-inactivation-pathway-in-hippocampal-neural-progenitor-cells
#12
Shin-Young Park, Min-Jeong Kang, Joong-Soo Han
We investigated the role of neuronal nitric oxide synthase (nNOS) in the neuronal differentiation of neural progenitor cells (NPCs) from hippocampi of E16.5 rat embryos. The production of nitric oxide (NO) and nNOS expression increased markedly during neuronal differentiation as did the expression of neurotrophin-3 (NT3), neurotrophin-4/5 (NT 4/5), and synapsin I. nNOS siRNA or the nNOS inhibitor, 7-nitroindazole (7-NI), decreased expression of the neurotrophins and synapsin I, and suppressed neurite outgrowth...
September 13, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27579744/atopic-dermatitis-allergic-dermatitis-or-neuroimmune-dermatitis
#13
Neide Kalil Gaspar, Márcia Kalil Aidé
Advances in knowledge of neurocellulars relations have provided new directions in the understanding and treatment of numerous conditions, including atopic dermatitis. It is known that emotional, physical, chemical or biological stimuli can generate more accentuated responses in atopic patients than in non-atopic individuals; however, the complex network of control covered by these influences, especially by neuropeptides and neurotrophins, and their genetic relations, still keep secrets to be revealed. Itching and airway hyperresponsiveness, the main aspects of atopy, are associated with disruption of the neurosensory network activity...
July 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/27519317/localization-of-trkb-and-p75-receptors-in-peritoneal-and-deep-infiltrating-endometriosis-an-immunohistochemical-study
#14
Agung Dewanto, Jozsef Dudas, Rudolf Glueckert, Sylvia Mechsner, Anneliese Schrott-Fischer, Ludwig Wildt, Beata Seeber
BACKGROUND: The roles of the neurotrophins NGF (Neurotrophic growth factor) and BDNF (brain-derived neurotrophic factor) in neuronal growth and development are already known. Meanwhile, the neurotrophin receptors TrkA (tropomyosin related kinase A), TrkB, and p75 are important for determining the fate of cells. In endometriosis, this complex system has not been fully elucidated yet. The aim of this study was to evaluate the expression and location of these neurotrophins and their receptors in peritoneal (PE) and deep infiltrating endometriotic (DIE) tissues and to measure and compare the density of nerve fibers in the disease subtypes...
August 12, 2016: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/27508959/brain-derived-neurotrophic-factor-a-mediator-of-inflammation-associated-neurogenesis-in-alzheimer-s-disease
#15
Jian-Jiao Chen, Tao Wang, Cai-di An, Chun-Yan Jiang, Jie Zhao, Shao Li
In early- or late-onset Alzheimer's disease (AD), inflammation, which is triggered by pathologic conditions, influences the progression of neurodegeneration. Brain-derived neurotrophic factor (BDNF) has emerged as a crucial mediator of neurogenesis, because it exhibits a remarkable activity-dependent regulation of expression, which suggests that it may link inflammation to neurogenesis. Emerging evidence suggests that acute and chronic inflammation in AD differentially modulates neurotrophin functions, which are related to the roles of inflammation in neuroprotection and neurodegeneration...
December 1, 2016: Reviews in the Neurosciences
https://www.readbyqxmd.com/read/27484434/exercise-induced-hypoalgesia-potential-mechanisms-in-animal-models-of-neuropathic-pain
#16
REVIEW
Katsuya Kami, Fumihiro Tajima, Emiko Senba
Physical exercise, such as forced treadmill running and swimming, can sufficiently improve mechanical allodynia and heat hyperalgesia in animal models of neuropathic pain (NPP), including partial sciatic nerve ligation, chronic constriction injury, and spinal nerve ligation models. Thus, physical exercise has been established as a low-cost, safe, and effective way to manage NPP conditions, but the exact mechanisms underlying such exercise-induced hypoalgesia (EIH) are not fully understood. A growing body of evidence has identified several factors that work at different levels of the nervous system as playing important roles in producing EIH in animal models of NPP...
January 2017: Anatomical Science International
https://www.readbyqxmd.com/read/27468425/measurement-of-inositol-triphosphate-levels-from-rat-hippocampal-slices
#17
Nino Tabatadze, Catherine Woolley
Inositol triphosphate (IP3) is an important second messenger that participates in signal transduction pathways in diverse cell types including hippocampal neurons. Stimulation of phospholipase C in response to various stimuli (hormones, growth factors, neurotransmitters, neurotrophins, neuromodulators, odorants, light, etc) results in hydrolysis of phosphatidylinositol 4, 5-bisphosphate (PIP2), a phospholipid that is located in the plasma membrane, and leads to the production of IP3 and diacylglycerol. Binding of IP3 to the IP3 receptor (IP3R) induces Ca(2+) release from intracellular stores and enables the initiation of intracellular Ca(2+)-dependent signaling...
April 5, 2016: Bio-protocol
https://www.readbyqxmd.com/read/27437725/nerve-growth-factor-promotes-expression-of-costimulatory-molecules-and-release-of-cytokines-in-dendritic-cells-involved-in-th2-response-through-lps-induced-p75ntr
#18
Hongyi Tan, Pinhua Pan, Lemeng Zhang, Zu Cao, Ben Liu, Haitao Li, Xiaoli Su
INTRODUCTION: Nerve growth factor (NGF) plays an important role in asthmatic inflammatory responses. However, the effects of NGF on dendritic cells (DCs) in asthmatic inflammation remain unknown. Therefore, we examined the effects of NGF on co-stimulatory molecules and the release of cytokines after ovalbumin (OVA) and a low dose of LPS (low LPS) stimulation of dendritic cells. METHODS: Bone-marrow-derived dendritic cells (BMDCs) were collected from 6- to 8-week-old wide or TLR4(-/-) mice...
December 2016: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/27425886/brain-derived-neurotrophic-factor-in-mood-disorders-and-antidepressant-treatments
#19
REVIEW
Eero Castrén, Masami Kojima
Levels of brain-derived neurotrophic factor (BDNF) are reduced in the brain and serum of depressed patients and at least the reduction in serum levels is reversible upon successful treatment. These data, together with a wealth of reports using different animal models with depression-like behavior or manipulation of expression of BDNF or its receptor TrkB have implicated BDNF in the pathophysiology of depression as well as in the mechanism of action of antidepressant treatments. Recent findings have shown that posttranslational processing of BDNF gene product can yield different molecular entities that differently influence signaling through BNDF receptor TrkB and the pan-neurotrophin receptor p75(NTR)...
January 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/27423610/canine-olfactory-ensheathing-cells-from-the-olfactory-mucosa-can-be-engineered-to-produce-active-chondroitinase-abc
#20
Darren Carwardine, Liang-Fong Wong, James W Fawcett, Elizabeth M Muir, Nicolas Granger
A multitude of factors must be overcome following spinal cord injury (SCI) in order to achieve clinical improvement in patients. It is thought that by combining promising therapies these diverse factors could be combatted with the aim of producing an overall improvement in function. Chondroitin sulphate proteoglycans (CSPGs) present in the glial scar that forms following SCI present a significant block to axon regeneration. Digestion of CSPGs by chondroitinase ABC (ChABC) leads to axon regeneration, neuronal plasticity and functional improvement in preclinical models of SCI...
August 15, 2016: Journal of the Neurological Sciences
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