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Olive leaf extract

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https://www.readbyqxmd.com/read/29149822/olive-leaf-extracts-act-as-modulators-of-the-human-immune-response
#1
Thea Magrone, Anna Spagnoletta, Rosaria Salvatore, Manrico Magrone, Francesco Dentamaro, Matteo Antonio Russo, Graziana Difonzo, Carmine Summo, Francesco Caponio, Emilio Jirillo
BACKGROUND: Olive tree leaves have been used in the Mediterranean area as traditional medicine in virtue of their healthy effects. Olive leaf extracts (OLEs) contain higher amounts of polyphenols than those detected in the extra virgin olive oil and fruit. Several lines of evidence support the cardioprotective, anti-oxidant and anti-inflammatory activities exerted by OLEs. METHODS: Peripheral blood mononuclear cells (PBMCs) from twenty-five healthy donors were cultured in the presence of 3 μg of two OLE extracts, extract A (resuspended in water) and extract B (resuspended in 70% ethanol)...
November 15, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29109370/olive-olea-europaea-l-biophenols-a-nutriceutical-against-oxidative-stress-in-sh-sy5y-cells
#2
Syed Haris Omar, Philip G Kerr, Christopher J Scott, Adam S Hamlin, Hassan K Obied
Plant biophenols have been shown to be effective in the modulation of Alzheimer's disease (AD) pathology resulting from free radical-induced oxidative stress and imbalance of the redox chemistry of transition metal ions (e.g., iron and copper). On the basis of earlier reported pharmacological activities, olive biophenols would also be expected to have anti-Alzheimer's activity. In the present study, the antioxidant activity of individual olive biophenols (viz. caffeic acid, hydroxytyrosol, oleuropein, verbascoside, quercetin, rutin and luteolin) were evaluated using superoxide radical scavenging activity (SOR), hydrogen peroxide (H₂O₂) scavenging activity, and ferric reducing ability of plasma (FRAP) assays...
October 29, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29099642/oleuropein-is-responsible-for-the-major-anti-inflammatory-effects-of-olive-leaf-extract
#3
Khaled Qabaha, Fuad Al-Rimawi, Ahmad Qasem, Saleh A Naser
Olive leaves are rich in polyphenolic compounds that are known to have antioxidant, antimicrobial, and anti-inflammatory activities. Therefore, olive leaf extract (OLE) is considered as a natural supplement. In this study we evaluated the antibacterial and the anti-inflammatory effect of OLE and its individual phenolic components in vitro. Polymorphonuclear cells (PMNCs) were isolated from the whole blood using Histopaque solution and cultured in RPMI-enriched medium. Tumor necrosis factor α (TNFα) level was determined by ELISA after 24 h of lipopolysaccharide stimulation...
November 3, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29057036/effects-of-chimonanthus-nitens-oliv-leaf-extract-on-glycolipid-metabolism-and-antioxidant-capacity-in-diabetic-model-mice
#4
Hui Chen, Yan Jiang, Zhanwei Yang, Wenbing Hu, Lei Xiong, Ning Wang, Xin Liu, Guodong Zheng, Kehui Ouyang, Wenjun Wang
The paper investigated the antihyperglycemic and antihyperlipidemic efficacy and antioxidant capacity of Chimonanthus nitens Oliv. leaf extract (COE) in combination of high-glucose-fat diet-fed and streptozotocin-induced diabetic model mice. Various physiological indexes in diabetic model mice were well improved especially by oral administration of high dose of COE; the results were listed as follows. Fast blood glucose (FBG) level and serum triglyceride (TC), total cholesterol (TG), low-density lipoprotein cholesterol (LDLC), and malondialdehyde (MDA) as well as MDA in liver were significantly reduced; fasting serum insulin (FINS) and insulin sensitivity index (ISI) were both increased; high-density lipoprotein cholesterol (HDLC) in serum was significantly increased; total antioxidant capacity (T-AOC), activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) in serum and liver were apparently enhanced; liver coefficient (LC), liver transaminase, and alkaline phosphatase (ALP) were decreased...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29039078/the-neuroprotective-effects-of-hydro-alcoholic-extract-of-olive-olea-europaea-l-leaf-on-rotenone-induced-parkinson-s-disease-in-rat
#5
Maryam Sarbishegi, Enam Alhagh Charkhat Gorgich, Ozra Khajavi, Gholamreza Komeili, Saeedeh Salimi
Parkinson's disease (PD) is an age-related disease in which dopaminergic neurons in the nigrostriatal pathway are destroyed, resulting in movement and behavioral problems. Oxidative stress and the generation of reactive oxygen species play key roles in neurodegenerative diseases, such as PD. Rotenone (ROT) is a common pesticide that induces oxidative stress. Olive leaves extract (OLE) has antioxidant and neuroprotective effects. Thus, the aim of this study was to investigate the neuroprotective effects of OLE on ROT-induced oxidative stress in the midbrain of a rat model of PD...
October 16, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29026388/cytotoxicity-testing-of-aqueous-extract-of-bitter-leaf-vernonia-amygdalina-del-and-sniper-1000ec-2-3-dichlorovinyl-dimethyl-phosphate-using-the-alium-cepa-test
#6
Jane Ogoamaka Okwuzu, Peter Odeiga, Olubunmi AdetoroOtubanjo, Oliver Chukwujekwu Ezechi
BACKGROUND: The unrefined nature of the herbal preparations from Vernonia amygdalina (VA) and toxicity potentials of Sniper may both have severe consequences on the biochemical and genetic systems. OBJECTIVES: To assess the microscopic and macroscopic effects of these substances. METHODS: VA leafs and Sniper were prepared and dissolved in distilled water to give different concentrations. Series of baseline tests were carried out to establish concentration range for root growth...
March 2017: African Health Sciences
https://www.readbyqxmd.com/read/28954421/the-effect-of-consumption-of-citrus-fruit-and-olive-leaf-extract-on-lipid-metabolism
#7
Nicola Merola, Julián Castillo, Obdulio Benavente-García, Gaspar Ros, Gema Nieto
Citrus fruit and olive leaves are a source of bioactive compounds such as biophenols which have been shown to ameliorate obesity-related conditions through their anti-hyperlipidemic and anti-inflammatory effect, and by regulating lipoproteins and cholesterol body levels. Citrolive™ is a commercial extract which is obtained from the combination of both citrus fruit and olive leaf extracts; hence, it is hypothesised that Citrolive™ may moderate metabolic disorders that are related to obesity and their complications...
September 26, 2017: Nutrients
https://www.readbyqxmd.com/read/28934660/antimicrobial-activity-of-some-natural-extracts-encapsulated-within-silica-matrices
#8
Alexandra Duprates Steiner, Alvaro Vargas, Nei Fronza, Adriano Brandelli, João Henrique Zimnoch Dos Santos
Natural extracts (anthocyanins, tannin, anatto, curcuma and olive leaf extracts) were encapsulated within a silica network by acid or base-catalyzed sol-gel methods. The nominal encapsulated contents were between 2.5 and 50wt.-%. The resulting materials were characterized by Fourier transform infrared spectroscopy, diffuse reflectance in the UV region, nitrogen adsorption/desorption porosimetry and small angle X-ray scattering. Encapsulated anthocyanin and tannin afforded inhibition zones between 9-21mm towards Staphylococcus aureus, Escherichia coli, Bacillus cereus, Candida sp...
September 12, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28881013/pencil-graphite-electrodes-for-improved-electrochemical-detection-of-oleuropein-by-the-combination-of-natural-deep-eutectic-solvents-and-graphene-oxide
#9
Federico J V Gomez, Adrian Spisso, María Fernanda Silva
A novel methodology is presented for the enhanced electrochemical detection of oleuropein in complex plant matrices by Graphene Oxide Pencil Grahite Electrode (GOPGE) in combination with a buffer modified with a Natural Deep Eutectic Solvent, containing 10% (v/v) of Lactic acid, Glucose and H2 O (LGH). The electrochemical behavior of oleuropein in the modified-working buffer was examined using differential pulse voltammetry. The combination of both modifications, NADES modified buffer and nanomaterial modified electrode, LGH-GOPGE, resulted on a signal enhancement of 5...
November 2017: Electrophoresis
https://www.readbyqxmd.com/read/28859105/programmed-cell-death-in-acanthamoeba-castellanii-neff-induced-by-several-molecules-present-in-olive-leaf-extracts
#10
Ines Sifaoui, Atteneri López-Arencibia, Carmen Mª Martín-Navarro, María Reyes-Batlle, Carolina Wagner, Olfa Chiboub, Mondher Mejri, Basilio Valladares, Manef Abderrabba, José E Piñero, Jacob Lorenzo-Morales
Therapy against Acanthamoeba infections such as Granulomatous Amoebic Encephalitis (GAE) and Acanthamoeba Keratitis (AK), remains as an issue to be solved due to the existence of a cyst stage which is highly resistant to most chemical and physical agents. Recently, the activity of Olive Leaf Extracts (OLE) was demonstrated against Acanthamoeba species. However, the molecules involved in this activity were not identified and/or evaluated. Therefore, the aim of this study was to evaluate the activity of the main molecules which are present in OLE and secondly to study their mechanism of action in Acanthamoeba...
2017: PloS One
https://www.readbyqxmd.com/read/28808475/yacon-smallanthus-sonchifolius-leaf-extract-attenuates-hyperglycemia-and-skeletal-muscle-oxidative-stress-and-inflammation-in-diabetic-rats
#11
Klinsmann Carolo Dos Santos, Bianca Guerra Bueno, Luana Ferreira Pereira, Fabiane Valentini Francisqueti, Mariana Gobbo Braz, Lahis Fernandes Bincoleto, Lilian Xavier da Silva, Ana Lúcia A Ferreira, Ana Cláudia de Melo Stevanato Nakamune, C-Y Oliver Chen, Jeffrey B Blumberg, Camila Renata Corrêa
The effects of hydroethanolic extract of Yacon leaves (HEYL) on antioxidant, glycemic, and inflammatory biomarkers were tested in diabetic rats. Outcome parameters included glucose, insulin, interleukin-6 (IL-6), and hydrophilic antioxidant capacity (HAC) in serum and IL-6, HAC, malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) in soleus. The rats (10/group) were divided as follows: C, controls; C + Y, HEYL treated; DM, diabetic controls; and DM + Y, diabetic rats treated with HEYL...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28802847/structural-antioxidant-and-antimicrobial-activities-of-polysaccharides-extracted-from-olive-leaves
#12
Ibtihel Khemakhem, Ola Abdelhedi, Ines Trigui, Mohamed Ali Ayadi, Mohamed Bouaziz
In the present study, hot-water extraction procedure was used to recover polysaccharides from olive leaves. Primary structural characteristics were determined by nuclear magnetic resonance spectroscopy ((1)H NMR and (13)C NMR), Fourier Transform-Infrared spectroscopy (FT-IR) and X-ray diffractometry analysis. Emulsifying capacity, Zeta (ζ) potential and differential scanning calorimetric (DSC) of olive leaf polysaccharides (OLP) were investigated. Antioxidant and antimicrobial activities were then examined...
August 9, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28740293/ultrasound-assisted-extraction-process-of-phenolic-antioxidants-from-olive-leaves-a-nutraceutical-study-using-rsm-and-lc-esi-dad-ms
#13
Habib Shirzad, Vahid Niknam, Mehdi Taheri, Hassan Ebrahimzadeh
In recent years, there has been an ever growing interest in finding new natural sources of food antioxidants. As a main fruit crop, olive is also valued due to its phenolic-containing leaves. Mathematically based optimization methods are used as powerful tools to extract different antioxidant compounds. The present study is aimed to provide an efficient extraction method for total phenol content (TPC), total flavonoid content (TFC) and antioxidant ability (DPPH scavenging assay and FRAP). The effects of ultrasonic temperature (35-65 °C), ultrasonic time (5-15 min), and ethanol to water ratio (Et: W) (25-75%) were evaluated...
July 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28731213/immunomodulatory-properties-of-olea-europaea-leaf-extract-in-intestinal-inflammation
#14
Teresa Vezza, Francesca Algieri, Alba Rodríguez-Nogales, José Garrido-Mesa, M Pilar Utrilla, Nassima Talhaoui, Ana María Gómez-Caravaca, Antonio Segura-Carretero, M Elena Rodríguez-Cabezas, Giovanni Monteleone, Julio Gálvez
SCOPE: Extracts from olive (Olea europaea) leaves are used in Mediterranean traditional medicine as anti-inflammatory agents. They contain antioxidant phenolic compounds, such as oleuropeoside, which could be interesting for the treatment of inflammatory conditions associated with oxidative stress in humans, including inflammatory bowel disease. METHODS AND RESULTS: The anti-inflammatory effects of olive leaf extract (0.5-25 mg/kg) were studied in two mice models of colitis (DSS and DNBS)...
July 21, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28700722/anti-inflammatory-properties-of-extracts-from-chimonanthus-nitens-oliv-leaf
#15
Qi Sun, Jiajin Zhu, Feiwei Cao, Fengjia Chen
Chimonanthus nitens Oliv. (CN) is a species in the family Calycanthaceae. Its leaf is widely used to make traditional herbal tea in southern China and has a wide range of therapeutic effects. The profile of the ethanol extracts from CN leaves was identified by UPLC-QTOF-MS/MS. Forty seven compounds were determined including organic acids, phenolic acids and derivatives, flavonoids, coumarins, fatty acids and other compounds. The effect of the CN extracts on the inflammatory damage in zebrafish and in RAW 264...
2017: PloS One
https://www.readbyqxmd.com/read/28672807/solvent-free-microwave-assisted-extraction-of-polyphenols-from-olive-tree-leaves-antioxidant-and-antimicrobial-properties
#16
Selin Şahin, Ruya Samli, Ayşe Seher Birteksöz Tan, Francisco J Barba, Farid Chemat, Giancarlo Cravotto, José M Lorenzo
Response surface methodology (RSM) and artificial neural networks (ANN) were evaluated and compared in order to decide which method was the most appropriate to predict and optimize total phenolic content (TPC) and oleuropein yields in olive tree leaf (Oleaeuropaea) extracts, obtained after solvent-free microwave-assisted extraction (SFMAE). The SFMAE processing conditions were: microwave irradiation power 250-350 W, extraction time 2-3 min, and the amount of sample 5-10 g. Furthermore, the antioxidant and antimicrobial activities of the olive leaf extracts, obtained under optimal extraction conditions, were assessed by several in vitro assays...
June 24, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28637415/study-on-adsorption-and-sustained-release-of-eucommia-ulmoides-oliv-leaf-extracts-on-activated-carbon
#17
Sheng Zhang, Xiang-Zhou Li, Zhao-Yan Zeng
Activated carbon (AC) was employed in this study as the sustained release carrier and its capability for adsorption and sustained release of Eucommia ulmoides Oliv. leaf extracts was systematically investigated. Acid or alkali modified AC was assessed for its ability to adsorb and sustain release of Eucommia ulmoides Oliv. leaf extracts according to a variety of adsorption/release rate and composition. Results demonstrated that the adsorption rate for the differently modified AC reached above 80 %, the adsorption of Eucommia ulmoides Oliv...
June 21, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28559631/effect-of-olive-leaf-extract-rich-in-oleuropein-on-the-quality-of-virgin-olive-oil
#18
Selin Şahin, Ezgi Sayım, Mehmet Bilgin
Effect of olive leaf extract rich in oleuropein on the quality of virgin olive oil was investigated. After extracting the dried and ground olive leaves with the assistance of homogenizer, the dried extract was partially dissolved into the oil to increase the oxidative stability of the oil. A face central composite design through response surface methodology was used to investigate the effects of enrichment conditions (extract content, time and mixing speed) on the responses, total phenolic content and oleuropein concentration of the enriched olive oil...
May 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28551177/new-semi-synthetic-analogs-of-oleuropein-show-improved-anticancer-activity-in%C3%A2-vitro-and-in%C3%A2-vivo
#19
Pinelopi Samara, Nikoleta Christoforidou, Christelle Lemus, Aikaterini Argyropoulou, Kyriaki Ioannou, Konstantina Vougogiannopoulou, Nektarios Aligiannis, Efthimios Paronis, Nicolas Gaboriaud-Kolar, Ourania Tsitsilonis, Alexios-Leandros Skaltsounis
Oleuropein is a glucosylated seco-iridoid present in olive fruits and leaves. Due to its broad spectrum of biological activities, including anticancer properties, oleuropein has attracted scientific attention for the past 20 years. The promising antiproliferative activity of an olive leaf extract enriched in oleuropein against a series of human cancer cell lines, prompted us to proceed with the semi-synthesis of 51 analogs of oleuropein. Following their initial screening against the estrogen receptor negative breast cancer cell line SKBR3, 7 analogs were shown to display significant cytotoxicity and were further tested against 6 additional solid tumor-derived and leukemic cell lines...
September 8, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28513570/a-study-of-the-protective-properties-of-iraqi-olive-leaves-against-oxidation-and-pathogenic-bacteria-in-food-applications
#20
Ammar B Altemimi
There is an ancient and prodigious history of olive trees because of their nutritional, medicinal, and traditional uses. Intensive studies have been conducted on olive leaves because they have many positive and beneficial effects for human health. In this study, different solvents were used to examine the olive leaves for their antioxidant and antimicrobial activities and their possible food applications. The obtained results showed that the amounts of phenolic compounds of the olive leaf were 190.44 ± 0.50, 173 ± 1...
May 17, 2017: Antioxidants (Basel, Switzerland)
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