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Olive leaf extract

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https://www.readbyqxmd.com/read/27918443/human-intervention-study-to-assess-the-effects-of-supplementation-with-olive-leaf-extract-on-peripheral-blood-mononuclear-cell-gene-expression
#1
Anna Boss, Chi Hsiu-Juei Kao, Pamela M Murray, Gareth Marlow, Matthew P G Barnett, Lynnette R Ferguson
Olive leaf extract (OLE) has been used for many years for its putative health benefits, but, to date, scientific evidence for the basis of these effects has been weak. Although recent literature has described a link between ailments such as cardiovascular disease, diabetes and cancer and a protective effect of polyphenols in the OLE, the mode of action is still unclear. Here, we describe a double-blinded placebo (PBO)-controlled trial, in which gene expression profiles of peripheral blood mononuclear cells from healthy male volunteers (n = 29) were analysed to identify genes that responded to OLE, following an eight-week intervention with 20 mL daily consumption of either OLE or PBO...
December 2, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27910900/zn-uptake-behavior-of-rice-genotypes-and-its-implication-on-grain-zn-biofortification
#2
Sarah E Johnson-Beebout, Johnvie Bayang Goloran, Francis H C Rubianes, Jack D C Jacob, Oliver B Castillo
Understanding Zn uptake dynamics is critical to rice grain Zn biofortification. Here we examined soil Zn availability and Zn uptake pathways as affected by genotype (high-grain Zn varieties IR69428 and IR68144), Zn fertilization and water management in two pot experiments. Results showed significant interactions (P < 0.05) between genotypes and Zn fertilization on DTPA (diethylenetriaminepentaacetic acid)-extractable soil Zn from early tillering to flowering. DTPA-extractable Zn in soils grown with IR69428 was positively correlated with stem (r = 0...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27882320/mediterrasian-diet-products-that-could-raise-hdl-cholesterol-a-systematic-review
#3
REVIEW
Mariangela Rondanelli, Attilio Giacosa, Paolo Morazzoni, Davide Guido, Mario Grassi, Gabriella Morandi, Chiara Bologna, Antonella Riva, Pietro Allegrini, Simone Perna
Background. High HDL-cholesterol (HDL-C) values are negatively correlated with cardiovascular diseases. This review analyses the effect of the supplementation with various Mediterranean diet products (artichoke, bergamot, and olive oil) and Asian diet products (red yeast rice) on the HDL-C value in dyslipidemic subjects. Methods. A systematic review has been done involving all the English written studies published from the 1st of January 1958 to the 31st of March 2016. Results. The results of this systematic review indicate that the dietary supplementation with red yeast rice, bergamot, artichoke, and virgin olive oil has promising effects on the increase of HDL-C serum levels...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27876915/effect-of-olive-leaf-satureja-khuzestanica-and-allium-sativum-extracts-on-giardia-lamblia-cysts-compared-with-metronidazole-in-vitro
#4
Sh Fallahi, A Rostami, B Delfan, Y Pournia, M Rashidipour
Giardia lamblia is one of the common causes of worldwide diarrhea in children. Appropriate medicinal treatment for giardiasis is available but there are some evidences of drug resistance, insufficient efficacy, and unpleasant side effects. In order to reach a more natural drug with suitable efficacy and the lowest side effects, the effects of the hydroalcoholic extracts of olive leaf, Satureja khuzestanica, and Allium sativum on G. lamblia cysts were evaluated in vitro, as well as antigiardial effect of the extracts was compared with metronidazole as the drug of choice...
December 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/27860303/effect-of-olive-leaf-extract-on-glucose-level-among-diabetes-induced-rats-a-systematic-review-and-meta-analysis
#5
Hamzeh Abunab, Wireen Leila Dator, Sana Hawamdeh
BACKGROUND: This systematic review statistically analyzed Randomized Controlled Trials on Olive Leaf Extract (OLE) for effectiveness in managing glucose levels in diabetic rats. METHODS: Selected articles, with no date restriction in the search process, were assessed independently by the authors using SYRCLE's risk of bias tool for animal studies. Comprehensive-Meta-analysis version 3.0 was used for data analysis. Findings from 8 trials that included 162 rats were reviewed...
November 17, 2016: Journal of Diabetes
https://www.readbyqxmd.com/read/27855900/selective-ultrasound-enhanced-enzymatic-hydrolysis-of-oleuropein-to-its-aglycon-in-olive-olea-europaea-l-leaf-extracts
#6
María Del Mar Delgado-Povedano, Feliciano Priego-Capote, María Dolores Luque de Castro
Hydrolysis of oleuropein, the main phenol in olive (Olea europaea L.) leaf extracts, to oleuropein aglycon and other subsequent products in the hydrolytic pathway can be catalyzed by different enzymes. Three of the most used hydrolases were assayed to catalyze the process, and β-glucosidase from Aspergillus niger was selected. Acceleration of the enzymatic hydrolysis by ultrasound (US) was studied using a Box-Behnken design (duty cycle, amplitude, cycle time) and an oleuropein standard, and the optimum US conditions for achieving maximum yield of oleuropein aglycon were 0...
April 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27854305/piper-sarmentosum-effects-on-11%C3%AE-hydroxysteroid-dehydrogenase-type-1-enzyme-in-serum-and-bone-in-rat-model-of-glucocorticoid-induced-osteoporosis
#7
Siti Fadziyah Mohamad Asri, Elvy Suhana Mohd Ramli, Ima Nirwana Soelaiman, Muhamad Alfakry Mat Noh, Abdul Hamid Abdul Rashid, Farihah Suhaimi
Glucocorticoid-induced osteoporosis is one of the common causes of secondary osteoporosis. Piper sarmentosum (Ps) extract possesses antioxidant and anti-inflammatory activities. In this study, we determined the correlation between the effects of Ps leaf water extract with the regulation of 11β-hydroxysteroid dehydrogenase (HSD) type 1 enzyme activity in serum and bone of glucocorticoid-induced osteoporotic rats. Twenty-four Sprague-Dawley rats were grouped into following: G1: sham-operated group administered with intramuscular vehicle olive oil and vehicle normal saline orally; G2: adrenalectomized (adrx) control group given intramuscular dexamethasone (120 μg/kg/day) and vehicle normal saline orally; G3: adrx group given intramuscular dexamethasone (120 μg/kg/day) and water extract of Piper sarmentosum (125 mg/kg/day) orally...
November 15, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27773270/kinetic-improvement-of-olive-leaves-bioactive-compounds-extraction-by-using-power-ultrasound-in-a-wide-temperature-range
#8
Ibtihel Khemakhem, Margarita Hussam Ahmad-Qasem, Enrique Barrajón Catalán, Vicente Micol, Jose Vicente García-Pérez, Mohamed Ali Ayadi, Mohamed Bouaziz
In this study, the effect of temperature and ultrasonic application on extraction kinetics of polyphenols from dried olive leaf was investigated. Conventional (CVE) and ultrasonic-assisted extraction (UAE) were performed at 10, 20, 30, 50 and 70°C using water as solvent. Extracts were characterized by measuring the total phenolic content, the antioxidant capacity and the oleuropein content (HPLC-DAD/MS-MS). Moreover, Naik's model was used to mathematically describe the extraction kinetics. The experimental results showed that phenolic extraction was faster in UAE (ultrasonic-assisted extraction) than in CVE (conventional extraction), being extraction kinetics satisfactorily described using Naik model (include VAR>98%)...
January 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/27738877/sasa-veitchii-extract-suppresses-carbon-tetrachloride-induced-hepato-and-nephrotoxicity-in-mice
#9
Hiroki Yoshioka, Miki Tanaka, Hirohisa Fujii, Tsunemasa Nonogaki
OBJECTIVE: The aim of this study was to investigate the therapeutic effects of a Sasa veitchii leaf extract (SE) on carbon tetrachloride (CCl4)-induced hepato- and nephrotoxicity. METHODS: Seven-week-old male ddy mice were orally administered SE or saline for seven days. Twenty-four hours after the last SE or saline administration, the mice were intraperitoneally injected with 3 g/kg CCl4 or olive oil. The mice from each group were euthanized and bled for plasma analysis 24 h after the CCl4/olive oil injection...
November 2016: Environmental Health and Preventive Medicine
https://www.readbyqxmd.com/read/27719659/cardioprotective-effects-of-the-polyphenol-hydroxytyrosol-from-olive-oil
#10
Silvia Tejada, Samuel Pinya, Maria Del Mar Bibiloni, Josep A Tur, Antoni Pons, Antoni Sureda
The Mediterranean diet includes olive oil as its primary source of fat. This diet is frequently associated to longevity and a lower incidence of chronic diseases thanks to its biological activities and health effects. Apart from oleic acid, olive oil contains many bioactive components including polyphenols that have been reported to exert antioxidant and anti-inflammatory activities. Polyphenols may for the most part be responsible for the protective effects against cardiovascular diseases associated with olive oil...
October 5, 2016: Current Drug Targets
https://www.readbyqxmd.com/read/27664677/effect-of-hydroxytyrosol-and-olive-leaf-extract-on-1-2-dicarbonyl-compounds-hydroxymethylfurfural-and-advanced-glycation-endproducts-in-a-biscuit-model
#11
Marta Navarro, Francisco J Morales
The antiglycative activity of hydroxytyrosol (HT) and olive leaf extract (OLE) was investigated in wheat-flour biscuits. Quercetin (QE) and gallic acid (GA) were used as reference of antiglycative activity of phenolic compounds. HT, OLE, QE and GA were added in the range of 0.25-0.75% (w/w). Samples were compared against a control recipe baked at 180°C/20min. HT biscuit was able to inhibit efficiently the formation of hydroxymethylfurfural (HMF) and 3-deoxyglucosone (3-DG), as well as reduced the formation of overall free fluorescent AGEs and pentosidine...
February 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27585435/nutritional-supplements-modulate-fluorescent-protein-bound-advanced-glycation-endproducts-and-digestive-enzymes-related-to-type-2-diabetes-mellitus
#12
Emily R Koch, Permal Deo
BACKGROUND: Chronic hyperglycemia enhances the formation of advanced glycation endproducts (AGEs) and reactive oxygen species (ROS), contributing to diabetic complications. Thus, controlling blood glucose levels, inhibiting the formation of AGEs and reducing ROS are key therapeutic targets in early stage type 2 diabetes. METHODS: The inhibitory effects of seven commercial liquid nutritional supplements against carbohydrate hydrolysing enzymes, α-amylase and α-glucosidase, was determined by dinitrosalicylic (DNS) reagent and p-nitrophenyl-α-D-glucopyranoside solution, respectively...
2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27567452/discrimination-of-wild-types-and-hybrids-of-duboisia-myoporoides-and-duboisia-leichhardtii-at-different-growth-stages-using-1-h-nmr-based-metabolite-profiling-and-tropane-alkaloids-targeted-hplc-ms-analysis
#13
Sophie Friederike Ullrich, Nils J H Averesch, Leonardo Castellanos, Young Hae Choi, Andreas Rothauer, Oliver Kayser
Duboisia species, which belong to the family of Solanaceae, are commercially cultivated in large scale, as they are main source of the pharmaceutically-used active compound scopolamine. In this study, (1)H NMR-based metabolite profiling linking primary with secondary metabolism and additional quantification via HPCL-MS with special focus on the tropane alkaloids were applied to compare leaf and root extracts of three wild types and two hybrids of Duboisia myoporoides and D. leichhardtii at different developmental stages grown under controlled conditions in climate chambers and under agricultural field plantation...
November 2016: Phytochemistry
https://www.readbyqxmd.com/read/27548217/evidence-to-support-the-anti-cancer-effect-of-olive-leaf-extract-and-future-directions
#14
REVIEW
Anna Boss, Karen S Bishop, Gareth Marlow, Matthew P G Barnett, Lynnette R Ferguson
The traditional Mediterranean diet (MD) is associated with long life and lower prevalence of cardiovascular disease and cancers. The main components of this diet include high intake of fruit, vegetables, red wine, extra virgin olive oil (EVOO) and fish, low intake of dairy and red meat. Olive oil has gained support as a key effector of health benefits and there is evidence that this relates to the polyphenol content. Olive leaf extract (OLE) contains a higher quantity and variety of polyphenols than those found in EVOO...
2016: Nutrients
https://www.readbyqxmd.com/read/27474292/determination-of-oleuropein-using-multiwalled-carbon-nanotube-modified-glassy-carbon-electrode-by-adsorptive-stripping-square-wave-voltammetry
#15
Mustafa Cittan, Süleyman Koçak, Ali Çelik, Kenan Dost
A multi-walled carbon nanotube modified glassy carbon electrode was used to prepare an electrochemical sensing platform for the determination of oleuropein. Results showed that, the accumulation of oleuropein on the prepared electrode takes place with the adsorption process. Electrochemical behavior of oleuropein was studied by using cyclic voltammetry. Compared to the bare GCE, the oxidation peak current of oleuropein increased about 340 times at MWCNT/GCE. Voltammetric determination of oleuropein on the surface of prepared electrode was studied using square wave voltammetry where the oxidation peak current of oleuropein was measured as an analytical signal...
October 1, 2016: Talanta
https://www.readbyqxmd.com/read/27386396/prevention-of-intraocular-pressure-elevation-with-oleuropein-rich-diet-in-rabbits-during-the-general-anaesthesia
#16
Tuncer Şimşek, Uğur Altınışık, İsmail Erşan, Hasan Şahin, Betül Altınışık, Mesut Erbaş, Çiğdem Pala
BACKGROUND: Oleuropein is known to have anti-oxidant and anti-inflammatory effects. An important aim of anesthetic management in ocular surgery is to keep the intraocular pressure under control. Studies have researched a variety of prophylactic materials used to prevent increases in intraocular pressure. We aimed to research the effects of oleuropein on intraocular pressure (IOP) during general anaesthesia. METHODS: Fourteen New Zealand rabbits were randomly divided into two groups of seven...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27383889/olive-leaf-extract-activity-against-candida-albicans-and-c-dubliniensis-the-in-vitro-viability-study
#17
Nataša Zorić, Nevenka Kopjar, Klara Kraljić, Nada Oršolić, Siniša Tomić, Ivan Kosalec
Olive leaf extract is characterized by a high content of polyphenols (oleuropein, hydroxytyrosol and their derivatives), which is associated with its therapeutic properties. The objective of the present research was to evaluate the antifungal activity of olive leaf extract against Candida albicans ATCC 10231 and C. dubliniensis CBS 7987 strains. Minimum inhibitory concentrations (MIC) of the extract were determined by several in vitro assays. The extract showed a concentration depended effect on the viability of C...
September 1, 2016: Acta Pharmaceutica
https://www.readbyqxmd.com/read/27376199/products-derived-from-olive-leaves-and-fruits-can-alter-in-vitro-ruminal-fermentation-and-methane-production
#18
P Shakeri, Z Durmic, J Vadhanabhuti, P E Vercoe
BACKGROUND: The industrial processing of olive generates a high quantity of by-products. The objective of this study was to examine the effects of products derived from olive trees, i.e. leaves, fruits or kernels as a sole substrate (part A), and crude extract from leaves combined with a substrate (part B) on rumen microbial fermentation in an in vitro batch fermentation system. In this study, total gas production, methane production, and concentrations of volatile fatty acids (VFA) and ammonia in ruminal fluid were measured...
July 4, 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27374563/phenolic-content-and-antioxidant-activity-of-olive-by-products-and-antioxidant-film-containing-olive-leaf-extract
#19
M Moudache, M Colon, C Nerín, F Zaidi
The antioxidant activity of olive leaf (OL) and cake (OC) extracts with different solvents was evaluated. 70% of aqueous ethanol extract of OL was chosen as the most antioxidant extract based on antiradical activity (DPPH) (95.4±0.3%) and oxygen radical absorbance capacity (ORAC) (0.82±0.07g equivalent Trolox per g of solution) assays. This OL extract was incorporated in two multilayer materials consisting of (i) polyethylene/polyethylene (PE/PE) film and (ii) polyethylene/paper (PE/P). These multilayers were exposed to a gas stream enriched in free radicals to evaluate the scavenging capacity of both materials...
December 1, 2016: Food Chemistry
https://www.readbyqxmd.com/read/27303302/olive-leaf-extract-from-sicilian-cultivar-reduced-lipid-accumulation-by-inducing-thermogenic-pathway-during-adipogenesis
#20
Rosa Palmeri, Julieta I Monteleone, Giovanni Spagna, Cristina Restuccia, Marco Raffaele, Luca Vanella, Giovanni Li Volti, Ignazio Barbagallo
Olive leaves contain a wide variety of phenolic compounds belonging to phenolic acids, phenolic alcohols, flavonoids, and secoiridoids, and include also many other pharmacological active compounds. They could play an important role in human diet and health because of their ability to lower blood pressure, increase coronary arteries blood flow and decrease the risk of cardiovascular diseases. The aim of this study was to investigate the effect of olive leaf extract (OLE) from Sicilian cultivar on adipogenic differentiation of human adipose derived mesenchymal stem cells and its impact on lipid metabolism...
2016: Frontiers in Pharmacology
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