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JOURNAL ARTICLE
Zainab M A Al Radi, Femke M Prins, Valerie Collij, Arnau Vich Vila, Eleonora A M Festen, Gerard Dijkstra, Rinse K Weersma, Marjolein A Y Klaassen, Ranko Gacesa
BACKGROUND: Inflammatory bowel diseases (IBDs) pose a significant challenge due to their diverse, often debilitating, and unpredictable clinical manifestations. The absence of prognostic tools to anticipate the future complications that require therapy intensification presents a substantial burden to patient private life and health. We aimed to explore whether the gut microbiome is a potential biomarker for future therapy intensification in a cohort of 90 IBD patients. METHODS: We conducted whole-genome metagenomics sequencing on fecal samples from these patients, allowing us to profile the taxonomic and functional composition of their gut microbiomes...
April 18, 2024: Inflammatory Bowel Diseases
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JOURNAL ARTICLE
Ali A Rabaan, Wadha A Alfouzan, Mohammed Garout, Muhammad A Halwani, Nouf Alotaibi, Mubarak Alfaresi, Nawal A Al Kaabi, Zainab H Almansour, Ahmed S Bueid, Amjad A Yousuf, Hamza M A Eid, Mohammed Alissa
In response to the escalating threat of drug-resistant fungi to human health, there is an urgent need for innovative strategies. Our focus is on addressing this challenge by exploring a previously untapped target, yeast casein kinase (Yck2), as a potential space for antifungal development. To identify promising antifungal candidates, we conducted a thorough screening of the diverse-lib drug-like molecule library, comprising 99,288 molecules. Five notable drug-like compounds with diverse-lib IDs 24334243, 24342416, 17516746, 17407455, and 24360740 were selected based on their binding energy scores surpassing 11 Kcal/mol...
April 18, 2024: Journal of Biomolecular Structure & Dynamics
#3
JOURNAL ARTICLE
Hai-Wei Deng, Rui Fan, Yuan-Sheng Zhai, Jie Li, Zhi-Bin Huang, Long-Yun Peng
BACKGROUND: Cancer patients are increasingly affected by chemotherapy-related cardiac dysfunction. The reported incidence of this condition vary significantly across different studies. HYPOTHESIS: A better comprehensive understanding of chemotherapy-related cardiac dysfunction incidence in cancer patients is imperative. Therefore, we performed a meta-analysis to establish the overall incidence of chemotherapy-related cardiac dysfunction in cancer patients. METHODS: We searched articles in PubMed and EMBASE from database inception to May 1, 2023...
April 2024: Clinical Cardiology
#4
JOURNAL ARTICLE
Ahmad Y Alqassim, Mohammed Badedi, Mohammed A Muaddi, Abdullah A Alharbi, Mohammad A Jareebi, Anwar M Makeen, Maged El-Setouhy, Osama B Albasheer, Abdullah Sabai, Ahmed Sahly
BACKGROUND: Dengue poses a considerable public health threat in Saudi Arabia, with escalating outbreaks in Jazan, where seasonal rains create ideal mosquito breeding conditions. Elucidating local epidemiological dynamics is imperative to strengthen evidence-based prevention policies. This study analyzed the spatiotemporal, demographic, and meteorological patterns of dengue in Jazan from 2015-2020. METHODS: This retrospective cross-sectional study utilized surveillance records for 3427 confirmed dengue cases...
April 18, 2024: Journal of Vector Borne Diseases
#5
Shubhada Jajoo, Suhas Jajoo, Rucha Naval
Isolated tubal torsion of the hydrosalpinx is a rare occurrence with a varied clinical presentation, presenting a diagnostic challenge. We present a case involving the isolated torsion of the right hydrosalpinx in a 33-year patient with a history of bilateral tubal ligation who presented with an acute abdomen. Based on ultrasound and clinical findings, an initial diagnosis of ovarian torsion was considered. However, escalating pain severity led to diagnostic laparotomy, revealing torsion in the right hydrosalpinx...
March 2024: Curēus
#6
JOURNAL ARTICLE
Meiqi Han, Yu Wang, Luyi Jing, Gucheng Yang, Yaoyao Liu, Fan Mo, Zhaojie Xu, Jinping Luo, Qianli Jia, Yuxin Zhu, Hanwen Cao, Xinxia Cai, Juntao Liu
The striatum plays a crucial role in studying epilepsy, as it is involved in seizure generation and modulation of brain activity. To explore the complex interplay between the striatum and epilepsy, we engineered advanced microelectrode arrays (MEAs) specifically designed for precise monitoring of striatal electrophysiological activities in rats. These observations were made during and following seizure induction, particularly three and 7 days post-initial modeling. The modification of graphene oxide (GO)/poly (3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS)/platinu-m nanoparticles (PtNPs) demonstrated a marked reduction in impedance (10...
2024: Frontiers in Bioengineering and Biotechnology
#7
JOURNAL ARTICLE
Linlin Wu, Haoqi Liu, Xuewen Xu, Chenjun Huang, Yueyue Li, Xiao Xiao, Yueping Zhan, Chunfang Gao
Stenosis severity may escalate over the course of coronary artery disease (CAD), increasing the risk of death for the patient. Conventionally, the assessment of stenosis degree relies on invasive coronary angiography (ICA), an invasive examination unsuitable for patients in poor physical condition or those with contrast allergies and one that imposes a psychological burden on patients. Although abnormal serum N-glycan profiles have exhibited robust associations with various cardiovascular diseases, including CAD, their potential in diagnosing CAD stenosis remains to be determined...
April 15, 2024: Heliyon
#8
REVIEW
Adhithyan T Pillai, Sonia Morya, Ladislaus Manaku Kasankala
Whey, a component of milk and a useful by-product of the dairy industry's casein and cheese-making, has been used for generations to augment animal feed. It contains a range of proteins, including α -lactalbumin, β -lactoglobulin, bovine serum albumin, heavy and light chain immunoglobulins, lactoferrin, glycomacropeptide, and lactoperoxidase. Whey proteins exhibit great potential as biopolymers for creating bioactive delivery systems owing to their distinct health-enhancing characteristics and the presence of numerous amino acid groups within their structures...
2024: Journal of Nutrition and Metabolism
#9
JOURNAL ARTICLE
M Laurette Hughes, Laura White, Mary Jane O'Brien, Judy Aubin, Carol Bradford
School closures in March 2020 due to the COVID-19 pandemic precipitated losses of critical student resources as physical, mental, emotional, and social needs escalated. Identifying the challenges, strategies, and changes in school nurse (SN) practice in Massachusetts during this pandemic is fundamental to understanding how to manage future anticipated pandemics while protecting children, communities, and SNs. The purpose of this mixed-methods descriptive study in the second year of the global pandemic was to (a) listen to SN voices through a novel online survey including the prompts of challenges, strategies, and practice changes and (b) describe the SN experience of COVID-19 response in Massachusetts schools, including identification of intent to leave school nursing...
April 18, 2024: Journal of School Nursing: the Official Publication of the National Association of School Nurses
#10
JOURNAL ARTICLE
Xiaoyan Yin, Wanqi Zhu, Xiaoyong Tang, Guangjian Yang, Xianguang Zhao, Kaikai Zhao, Liyang Jiang, Xiaolin Li, Hong Zhao, Xin Wang, Yuanyuan Yan, Ligang Xing, Jinming Yu, Xiangjiao Meng, Hanxi Zhao
BACKGROUND: The antiviral drug Nirmatrelvir was found to be a key drug in controlling the progression of pneumonia during the infectious phase of COVID-19. However, there are very few options for effective treatment for cancer patients who have viral pneumonia. Glucocorticoids is one of the effective means to control pneumonia, but there are many adverse events. EGCG is a natural low toxic compound with anti-inflammatory function. Thus, this study was designed to investigate the safety and efficacy of epigallocatechin-3-gallate (EGCG) aerosol to control COVID-19 pneumonia in cancer populations...
April 17, 2024: BMC Cancer
#11
JOURNAL ARTICLE
Sakshi Thakur, Vishal Mutreja, Ranjeet Kaur
The escalating demand for the antibiotic drug tetracycline hydrochloride (TCH) contributes to an increased release of its residues into land and water bodies, which poses risks to both aquatic life and human health. Therefore, it is precedence to effectively degrade TCH residues to protect environment from their long-term impacts. In this aspect, the present study entails the synthesis of zirconia (ZrO2 ) nanostructures and focuses on the enhancement in the catalytic performance of ZrO2 nanostructures by employing reduced graphene oxide (RGO) as a solid support to synthesize ZrO2 -enriched RGO-based photocatalysts (ZrO2 -RGO) for the degradation of TCH...
April 18, 2024: Environmental Science and Pollution Research International
#12
JOURNAL ARTICLE
Brittney D Browning, Anna E Kirkland, Rejoyce Green, Helen Liu, Janiece S Glover, Taylor D Ticer, Mindy A Engevik, Alexander V Alekseyenko, Pamela L Ferguson, Rachel L Tomko, Lindsay M Squeglia
BACKGROUND: Adolescence is a sensitive stage of oral microbial development that often coincides with the initiation and escalation of alcohol use. Thus, adolescents may be particularly susceptible to alcohol-induced alterations in the oral microbiome, though minimal research has been done in this area. Understanding the connection between the oral microbiome and alcohol use during adolescence is important to understand fully the biological consequences of alcohol use to mitigate potential adverse outcomes...
April 17, 2024: Alcohol Clin Exp Res (Hoboken)
#13
JOURNAL ARTICLE
Nicola J Wyatt, Hannah Watson, Carl A Anderson, Nicholas A Kennedy, Tim Raine, Tariq Ahmad, Dean Allerton, Michelle Bardgett, Emma Clark, Dawn Clewes, Cristina Cotobal Martin, Mary Doona, Jennifer A Doyle, Katherine Frith, Helen C Hancock, Ailsa L Hart, Victoria Hildreth, Peter M Irving, Sameena Iqbal, Ciara Kennedy, Andrew King, Sarah Lawrence, Charlie W Lees, Robert Lees, Laura Letchford, Trevor Liddle, James O Lindsay, Rebecca H Maier, John C Mansfield, Julian R Marchesi, Naomi McGregor, Rebecca E McIntyre, Jasmin Ostermayer, Tolulope Osunnuyi, Nick Powell, Natalie J Prescott, Jack Satsangi, Shriya Sharma, Tara Shrestha, Ally Speight, Michelle Strickland, James Ms Wason, Kevin Whelan, Ruth Wood, Gregory R Young, Xinyue Zhang, Miles Parkes, Christopher J Stewart, Luke Jostins-Dean, Christopher A Lamb
INTRODUCTION: Characterised by chronic inflammation of the gastrointestinal tract, inflammatory bowel disease (IBD) symptoms including diarrhoea, abdominal pain and fatigue can significantly impact patient's quality of life. Therapeutic developments in the last 20 years have revolutionised treatment. However, clinical trials and real-world data show primary non-response rates up to 40%. A significant challenge is an inability to predict which treatment will benefit individual patients...
April 17, 2024: BMJ Open
#14
JOURNAL ARTICLE
Shin Urai, Seiji Tomofuji, Hironori Bando, Maki Kanzawa, Masaaki Yamamoto, Hidenori Fukuoka, Masahiro Tsuda, Genzo Iguchi, Wataru Ogawa
Anti-pituitary-specific transcription factor-1 (PIT-1) hypophysitis, a paraneoplastic syndrome resulting from an autoimmune response against PIT-1, typically manifests with undetectable levels of growth hormone (GH) and prolactin (PRL), and significantly low levels of serum thyroid-stimulating hormone (TSH) at diagnosis. These hormonal levels are highly specific to this disease and serve as key diagnostic indicators. Herein, we present a detailed clinical course of a 69-year-old male with a history of gastric cancer and lymph node metastases who developed anti-PIT-1 hypophysitis after the initiation of immune checkpoint inhibitor (ICI) therapy, specifically nivolumab, oxaliplatin, and capecitabine...
April 17, 2024: Journal of Neuroendocrinology
#15
JOURNAL ARTICLE
Gajender Kumar Sharma, Vidya V Ghuge
Air pollution is a matter of great significance that confronts the sustainable progress of urban areas. Against India's swift urbanization, several urban areas exhibit the coexistence of escalating populace and expansion in developed regions alongside extensive spatial heterogeneity. The interaction mechanism between the growth of urban areas and the expansion of cities holds immense importance for the remediation of air pollution. Henceforth, the present investigation utilizes geographically weighted regression (GWR) to examine the influence of urban expansion and population growth on air quality...
April 15, 2024: Science of the Total Environment
#16
JOURNAL ARTICLE
Euidam Kim, Ji Sung Yoo, Yeon-Joo Kim, Jungnam Joo, Eun Sang Oh, Yoonsun Chung, Seung Hyun Chung, Tae Hyun Kim
PURPOSE: Regional nodal irradiation (RNI) to the axilla and supraclavicular area presents distinct toxicities, such as lymphedema and shoulder stiffness, compared to whole-breast irradiation. There is insufficient evidence on the safety of dose-escalation in hypofractionated RNI. We aimed to evaluate and compare toxicity rates in patients with breast cancer who received hypofractionated RNI with and without dose-escalation. METHODS: We retrospectively analyzed 381 patients with breast cancer treated with hypofractionated RNI between March 2015 and February 2017...
April 15, 2024: International Journal of Radiation Oncology, Biology, Physics
#17
JOURNAL ARTICLE
Johannes Rosenbrock, Helen Kaul, Michael Oertel, Eren Celik, Philipp Linde, Jiaqi Fan, Dennis A Eichenauer, Paul J Broeckelmann, Bastian von Tresckow, Carsten Kobe, Markus Dietlein, Michael Fuchs, Peter Borchmann, Hans Theodor Eich, Christian Baues
PURPOSE: Combined modality treatment (CMT) with chemotherapy followed by consolidation radiotherapy (RT), provides excellent outcomes for patients with early-stage Hodgkin lymphoma (HL). The international standard of care for consolidation RT, involved-site/involved-node radiotherapy (ISRT/INRT), has never been evaluated in a randomized phase III trial against the former standard involved-field radiotherapy (IFRT). METHODS AND MATERIALS: In the multicenter phase III AnonymizedStudyGroupXXX AnonymizedStudyYYY trial, patients with early stage unfavorable HL were randomized between the standard CMT group and a positron-emission tomography (PET) -guided group...
April 15, 2024: International Journal of Radiation Oncology, Biology, Physics
#18
REVIEW
Ganapaty Manickavasagam, Chao He, Kun-Yi Andrew Lin, Mardiana Saaid, Wen-Da Oh
The escalation of global water pollution due to emerging pollutants has gained significant attention. To address this issue, catalytic peroxymonosulfate (PMS) activation technology has emerged as a promising treatment approach for effectively decontaminating a wide range of pollutants. Recently, modified biochar has become an increasingly attractive as PMS activator. Metal-heteroatom-co-doped biochar (MH-BC) has emerged as a promising catalyst that can provide enhanced performance over heteroatom-doped and metal-doped biochar due to the synergism between metal and heteroatom in promoting PMS activation...
April 15, 2024: Environmental Research
#19
JOURNAL ARTICLE
Yanan Yuan, Yanfei Zhang, Mingwei Wang, Jiankun Cao, Hongyuan Yan
The escalating use of pesticides on fruits and vegetables has raised concerns about potential health risks. Therefore, we developed a superhydrophilic resin/graphene oxide (SR/GO) with rich adsorption interactions using an eco-friendly synthetic approach. SR/GO demonstrated excellent hydrophilicity, ensuring optimal contact with aqueous sample matrices. The multiple adsorption interactions, including π-π conjugation, hydrogen bonding, and electrostatic adsorption, facilitated multi-pesticide residue co-extraction...
April 16, 2024: Food Chemistry
#20
JOURNAL ARTICLE
Attaya Suvannasankha, Nizar Bahlis, Suzanne Trudel, Katja Weisel, Christian Koenecke, Albert Oriol, Peter M Voorhees, Aranzazu A Alonso, Natalie S Callander, María-Victoria Mateos, Nishitha Reddy, Shawn Hakim, John LaMacchia, Nashita Patel, Danaé Williams, Roxanne C Jewell, Xiangdong Zhou, Ira Gupta, Joanna Opalinska, Ajay K Nooka
BACKGROUND: Belantamab mafodotin (belamaf) has shown promising antimyeloma activity in relapsed or refractory multiple myeloma (RRMM) as a single agent. It was hypothesized that its multimodal activity may be enhanced by programmed cell death protein 1 pathway inhibition and activation of T cell-mediated antitumor responses. This study investigated the efficacy and safety of belamaf with pembrolizumab in patients with RRMM. METHODS: DREAMM-4 (NCT03848845) was an open-label, single-arm, phase 1/2 study divided into dose-escalation (part 1) and dose-expansion (part 2) phases...
April 17, 2024: Cancer
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