Lakshmi Rajdev, Chia-Ching Jackie Wang, Himanshu Joshi, Shelly Lensing, Jeannette Lee, Juan Carlos Ramos, Robert Baiocchi, Lee Ratner, Paul G Rubinstein, Richard Ambinder, David Henry, Howard Streicher, Richard F Little, Elizabeth Chiao, Dirk P Dittmer, Mark H Einstein, Ethel Cesarman, Ronald Mitsuyasu, Joseph A Sparano
BACKGROUND: Although immunotherapy has emerged as a therapeutic strategy for many cancers, there are limited studies establishing the safety and efficacy in people living with HIV (PLWH) and cancer. METHODS: PLWH and solid tumors or Kaposi sarcoma (KS) receiving antiretroviral therapy and a suppressed HIV viral load received nivolumab at 3 mg/kg every 2 weeks, in two dose deescalation cohorts stratified by CD4 count (stratum 1: CD4 count > 200/µL and stratum 2: CD4 count 100-199/µL)...
November 14, 2023: Cancer