Omotola O Olasupo, Charles Nakar, Craig Haddix, Thushara Matthew, Davide Matino, Lynn Malec, Lawrence Mbuagbaw, Jean-Eric Tarride, Alfonso Iorio, Amy D Shapiro
BACKGROUND: The development of antibodies (inhibitors) to clotting factors compromises the management of hemophilia A and B, resulting in resistance to clotting factor replacement and, in many cases, the need for bypassing agents to achieve hemostasis. OBJECTIVES: To evaluate the association between the presence of inhibitors and achievement of perioperative hemostasis, development of complications, and presurgical plan deviations. METHODS: We conducted a retrospective study using data from the Indiana Hemophilia and Thrombosis Center surgical database (1998-2019)...
October 2023: Research and Practice in Thrombosis and Haemostasis