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https://www.readbyqxmd.com/read/29772098/insights-in-particulate-matter-induced-allergic-airway-inflammation-focus-on-the-epithelium
#1
Katrien C De Grove, Sharen Provoost, Guy G Brusselle, Guy F Joos, Tania Maes
Outdoor air pollution is a major environmental health problem throughout the world. In particular, exposure to particulate matter (PM) has been associated with the development and exacerbation of several respiratory diseases, including asthma. Although the adverse health effects of PM have been demonstrated for many years, the underlying mechanisms have not been fully identified. In this review, we focus on the role of the lung epithelium and specifically highlight multiple cytokines in PM-induced respiratory responses...
May 17, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29766006/interaction-between-air-pollutants-and-pollen-grains-the-role-on-the-rising-trend-in-allergy
#2
Farnaz Sedghy, Abdol-Reza Varasteh, Mojtaba Sankian, Malihe Moghadam
Asthma and allergic diseases cases have risen in recent decades. Plant pollen is considered as the main aeroallergen causing allergic reactions. According to available data, urban residents experience more respiratory allergies than rural residents mainly due to the interaction between chemical air pollutants and pollen grains. This interaction can occur through several mechanisms; chemical pollutants might facilitate pollen allergen release, act as adjuvants to stimulate IgE-mediated responses, modify allergenic potential, and enhance the expression of some allergens in pollen grains...
April 2018: Reports of Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/29748453/treatment-strategy-of-allergic-rhinitis-in-the-face-of-modern-world-threats
#3
Piotr Rapiejko, Dariusz Jurkiewicz, Wioletta Pietruszewska, Beata Zielnik-Jurkiewicz, Jarosław Woroń, Agnieszka Lipiec
Allergic rhinitis (AR) is the most common form of allergy, which - as epidemiological research has shown - applies to nearly 25% of the population. AR significantly affects the quality of life of the patient, and the more severe the disease, the greater the risk of developing bronchial asthma. One of the factors affecting the severity of symptoms and the degree of their control is air pollution. In some patients, despite proper treatment, persistence or only partial remission of symptoms (uncontrolled allergic rhinitis) is observed...
April 30, 2018: Otolaryngologia Polska
https://www.readbyqxmd.com/read/29747661/modelling-the-asthma-phenotype-impact-of-cigarette-smoke-exposure
#4
Maria G Belvisi, Katie Baker, Nicole Malloy, Kristof Raemdonck, Bilel Dekkak, Michael Pieper, Anthony T Nials, Mark A Birrell
BACKGROUND: Asthmatics that are exposed to inhaled pollutants such as cigarette smoke (CS) have increased symptom severity. Approximately 25% of adult asthmatics are thought to be active smokers and many sufferers, especially in the third world, are exposed to high levels of inhaled pollutants. The mechanism by which CS or other airborne pollutants alter the disease phenotype and the effectiveness of treatment in asthma is not known. The aim of this study was to determine the impact of CS exposure on the phenotype and treatment sensitivity of rodent models of allergic asthma...
May 10, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29743784/high-prevalence-of-chronic-respiratory-symptoms-among-autorickshaw-drivers-of-urban-puducherry-south-india
#5
Peter Stephen, Thulasingam Mahalakshmy, Rajaram Manju, Karthik B Laksham, Sudalai Subramani, Kanhu Panda, Sonali Sarkar
Context: Auto-rickshaw (three wheelers open cabin type of vehicle) drivers are exposed to traffic air pollution. Studies have demonstrated reduced pulmonary function among drivers. However, limited studies have determined the prevalence of chronic respiratory symptoms or chronic obstructive pulmonary disease (COPD) among drivers. Aims: Among auto-rickshaw drivers of urban Puducherry to determine prevalence of (i) chronic respiratory symptoms by using Indian Study on Epidemiology of Asthma, Respiratory Symptoms, and Chronic Bronchitis (INSEARCH) questionnaire and (ii) COPD by measuring peak expiratory flow rate (PEFR)...
January 2018: Indian Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29733456/oxidative-damage-of-sp-d-abolishes-control-of-eosinophil-extracellular-dna-trap-formation
#6
Shida Yousefi, Satish K Sharma, Darko Stojkov, Nina Germic, Salome Aeschlimann, Moyar Q Ge, Cameron H Flayer, Erik D Larson, Imre G Redai, Suhong Zhang, Cynthia J Koziol-White, Katalin Karikó, Hans-Uwe Simon, Angela Haczku
The asthmatic airways are highly susceptible to inflammatory injury by air pollutants such as ozone (O3 ), characterized by enhanced activation of eosinophilic granulocytes and a failure of immune protective mechanisms. Eosinophil activation during asthma exacerbation contributes to the proinflammatory oxidative stress by high levels of nitric oxide (NO) production and extracellular DNA release. Surfactant protein-D (SP-D), an epithelial cell product of the airways, is a critical immune regulatory molecule with a multimeric structure susceptible to oxidative modifications...
May 7, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29727820/main-components-of-pm-10-in-an-area-influenced-by-a-cement-plant-in-catalonia-spain-seasonal-and-daily-variations
#7
Joaquim Rovira, Jordi Sierra, Martí Nadal, Marta Schuhmacher, José L Domingo
Particulate matter (PM) composition has a key role in a wide range of health outcomes, such as asthma, chronic obstructive pulmonary disease, lung cancer, cardiovascular disease, and death, among others. Montcada i Reixac, a municipality located in the Barcelona metropolitan area (Catalonia, Spain), for its location and orography, is an interesting case- study to investigate air pollution. The area is also characterized by the presence of different industrial emission sources, including a cement factory and a large waste management plant, as well as an intense traffic...
May 1, 2018: Environmental Research
https://www.readbyqxmd.com/read/29725457/function-of-pm2-5-in-the-pathogenesis-of-lung-cancer-and-chronic-airway-inflammatory-diseases
#8
REVIEW
Ruyi Li, Rui Zhou, Jiange Zhang
Previous research has identified that air pollution is associated with various respiratory diseases, but few studies have investigated the function served by particulate matter 2.5 (PM2.5) in these diseases. PM2.5 is known to cause epigenetic and microenvironmental alterations in lung cancer, including tumor-associated signaling pathway activation mediated by microRNA dysregulation, DNA methylation, and increased levels of cytokines and inflammatory cells. Autophagy and apoptosis of tumor cells may also be detected in lung cancer associated with PM2...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29724254/radical-containing-combustion-derived-particulate-matter-enhance-pulmonary-th17-inflammation-via-the-aryl-hydrocarbon-receptor
#9
Sridhar Jaligama, Vivek S Patel, Pingli Wang, Asmaa Sallam, Jeffrey Harding, Matthew Kelley, Skylar R Mancuso, Tammy R Dugas, Stephania A Cormier
BACKGROUND: Pollutant particles containing environmentally persistent free radicals (EPFRs) are formed during many combustion processes (e.g. thermal remediation of hazardous wastes, diesel/gasoline combustion, wood smoke, cigarette smoke, etc.). Our previous studies demonstrated that acute exposure to EPFRs results in dendritic cell maturation and Th17-biased pulmonary immune responses. Further, in a mouse model of asthma, these responses were enhanced suggesting exposure to EPFRs as a risk factor for the development and/or exacerbation of asthma...
May 3, 2018: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/29720562/airway-responsiveness-to-methacholine-and-incidence-of-copd-an-international-prospective-cohort-study
#10
Alessandro Marcon, Francesca Locatelli, Dirk Keidel, Anna B Beckmeyer-Borowko, Isa Cerveri, Shyamali C Dharmage, Elaine Fuertes, Judith Garcia-Aymerich, Joachim Heinrich, Medea Imboden, Christer Janson, Ane Johannessen, Bénédicte Leynaert, Silvia Pascual Erquicia, Giancarlo Pesce, Emmanuel Schaffner, Cecilie Svanes, Isabel Urrutia, Deborah Jarvis, Nicole M Probst-Hensch, Simone Accordini
BACKGROUND: It has been debated, but not yet established, whether increased airway responsiveness can predict COPD. Recognising this link may help in identifying subjects at risk. OBJECTIVE: We studied prospectively whether airway responsiveness is associated with the risk of developing COPD. METHODS: We pooled data from two multicentre cohort studies that collected data from three time points using similar methods (European Community Respiratory Health Survey and Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults)...
May 2, 2018: Thorax
https://www.readbyqxmd.com/read/29716592/pollution-and-respiratory-disease-can-diet-or-supplements-help-a-review
#11
REVIEW
T Whyand, J R Hurst, M Beckles, M E Caplin
Pollution is known to cause and exacerbate a number of chronic respiratory diseases. The World Health Organisation has placed air pollution as the world's largest environmental health risk factor. There has been recent publicity about the role for diet and anti-oxidants in mitigating the effects of pollution, and this review assesses the evidence for alterations in diet, including vitamin supplementation in abrogating the effects of pollution on asthma and other chronic respiratory diseases. We found evidence to suggest that carotenoids, vitamin D and vitamin E help protect against pollution damage which can trigger asthma, COPD and lung cancer initiation...
May 2, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29714636/extracellular-vesicles-released-in-response-to-respiratory-exposures-implications-for-chronic-disease
#12
Birke J Benedikter, Emiel F M Wouters, Paul H M Savelkoul, Gernot G U Rohde, Frank R M Stassen
Extracellular vesicles (EV) are secreted signaling entities that enhance various pathological processes when released in response to cellular stresses. Respiratory exposures such as cigarette smoke and air pollution exert cellular stresses and are associated with an increased risk of several chronic diseases. The aim of this review was to examine the evidence that modifications in EV contribute to respiratory exposure-associated diseases. Publications were searched using PubMed and Google Scholar with the search terms (cigarette smoke OR tobacco smoke OR air pollution OR particulate matter) AND (extracellular vesicles OR exosomes OR microvesicles OR microparticles OR ectosomes)...
May 1, 2018: Journal of Toxicology and Environmental Health. Part B, Critical Reviews
https://www.readbyqxmd.com/read/29714103/traffic-related-air-pollution-lung-function-and-host-vulnerability-new-insights-from-the-paris-birth-cohort
#13
Nicolas Bougas, Fanny Rancière, Nicole Beydon, Malika Viola, Xavier Perrot, Stephan Gabet, Guillaume Lezmi, Flore Amat, Jacques De Blic, Jocelyne Just, Isabelle Momas
RATIONALE: Although the effects of traffic-related air pollution on respiratory exacerbations have been well documented, its impact on lung function in childhood remains unclear. OBJECTIVES: Our aim was to investigate the associations of prenatal, early, and lifetime traffic-related air pollution exposure with lung function at 8-9 years studying possible effect modification by sex, sensitization at 8-9 years, and early lower respiratory tract infections. METHODS: We conducted this study among 788 children from the PARIS (Pollution and Asthma Risk: an Infant Study) birth cohort...
May 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29710614/organic-uv-filters-exposure-induces-the-production-of-inflammatory-cytokines-in-human-macrophages
#14
Junjie Ao, Tao Yuan, Li Gao, Xiaodan Yu, Xiaodong Zhao, Ying Tian, Wenjin Ding, Yuning Ma, Zhemin Shen
Organic ultraviolet (UV) filters, found in many personal care products, are considered emerging contaminants due to growing concerns about potential long-term deleterious effects. We investigated the immunomodulatory effects of four commonly used organic UV filters (2-hydroxy-4-methoxybenzophenone, BP-3; 4-methylbenzylidene camphor, 4-MBC; 2-ethylhexyl 4-methoxycinnamate, EHMC; and butyl-methoxydibenzoylmethane, BDM) on human macrophages. Our results indicated that exposure to these four UV filters significantly increased the production of various inflammatory cytokines in macrophages, particular tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6)...
April 20, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29708861/occupational-exposures-of-flour-dust-and-airborne-chemicals-at-bakeries-in-taiwan
#15
Pei-Ting Chang, Po-Chen Hung, Shih-Wei Tsai
Walk-through surveys were carried out for bakeries in this study to determine the environmental characteristics of bakeries in Taiwan. Questionnaires were administrated to discover whether job-related asthma-like symptoms occurred among workers. Air sampling and analysis were also performed. The results show that the levels of inhalable flour dust ranged from 0.01 to 0.83 mg m-3 with an average of 0.27 mg m-3 . Among the samples collected, 23% of them had concentrations higher than the ACGIH TLV-TWA (0.5 mg m-3 ), which indicated that inhalable flour dust was an important air pollutant for bakery workers in Taiwan...
April 30, 2018: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/29698555/short-term-effect-of-outdoor-mold-spore-exposure-on-prescribed-allergy-medication-sales-in-central-france
#16
D M Caillaud, M Cheriaux, S Martin, C Ségala, N Dupuy, B Evrard, M Thibaudon
BACKGROUND: Outdoor molds are classically associated with exacerbations of asthma. OBJECTIVE: The aim of the present paper was to examine nasal allergy morbidity by studying the short-term relationship between mold spore exposure and daily sales of reimbursable anti-allergic treatment in central France. METHODS: The relationship between daily changes in mold concentrations and daily sales obtained from the national health care database was analysed with generalized additive models, taking into account confounding factors such as air pollution, weather conditions, pollen counts and days of the week...
April 26, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29692372/influence-of-air-pollution-on-hospital-admissions-in-adult-asthma-in-northeast-china
#17
Ying Liu, Hao-Dong Wang, Zhen-Xiang Yu, Shu-Cheng Hua, Li-Ting Zhou, Li-Ping Peng
Background: Asthma is a common chronic respiratory disease and is related to air pollution exposure. However, only a few studies have concentrated on the association between air pollution and adult asthma. Moreover, the results of these studies are controversial. Therefore, the present study aimed to analyze the influence of various pollutants on hospitalization due to asthma in adults. Methods: A total of 1019 unrelated hospitalized adult asthma patients from Northeast China were recruited from 2014 to 2016...
May 5, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29692198/nasal-dna-methylation-is-associated-with-childhood-asthma
#18
Xue Zhang, Jocelyn M Biagini Myers, J D Burleson, Ashley Ulm, Kelly S Bryan, Xiaoting Chen, Matthew T Weirauch, Theresa A Baker, Melinda S Butsch Kovacic, Hong Ji
AIM: We aim to study DNA methylation (DNAm) variations associated with childhood asthma. METHODS: Nasal DNAm was compared between sibling pairs discordant for asthma, 29 sib pairs for genome-wide association studies and 54 sib pairs for verification by pyrosequencing. Associations of methylation with asthma symptoms, allergy and environmental exposures were evaluated. In vitro experiments and functional genomic analyses were performed to explore biologic relevance...
April 25, 2018: Epigenomics
https://www.readbyqxmd.com/read/29683206/the-effects-of-air-pollution-on-length-of-hospital-stay-for-adult-patients-with-asthma
#19
Li Luo, Jing Ren, Fengyi Zhang, Wei Zhang, Chunyang Li, Zhixin Qiu, Debin Huang
Length of hospital stay (LOS) of asthma can be a reflection of the disease burden faced by patients, and it is also sensitive to air pollution. This study aims at estimating and validating the effects of air pollution and readmission on the LOS for those who have asthma, considering their readmission history, minimum temperature, and threshold effects of air pollutants. In addition, sex, age, and season were also constructed for stratification to achieve more precise and specific results. The results show that no significant effects of PM2...
April 23, 2018: International Journal of Health Planning and Management
https://www.readbyqxmd.com/read/29676646/ambient-air-pollution-and-clinical-implications-for-susceptible-populations
#20
Laura G Hooper, Joel D Kaufman
Air pollution is associated with a diversity of health effects, and evidence for a causal relationship with specific diseases exists. Exposure to air pollution is ubiquitous and typically beyond the control of the individual; the resulting health burden for the population can be high. Disproportionate effects are seen in individuals who have increased susceptibility to air pollution owing to individual- or community-level characteristics. As studies grow increasingly sophisticated, the understanding of who comprises the susceptible population continuously expands...
April 2018: Annals of the American Thoracic Society
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