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https://www.readbyqxmd.com/read/29150353/barrier-dysfunction-in-the-nasal-allergy
#1
REVIEW
Ayumi Fukuoka, Tomohiro Yoshimoto
Epithelial cells form the first physiological barrier against invasion by pathogens and the infiltration of allergens. Tight junctions (TJ), a cell-cell junctional complex located on the apical side of epithelial cells, have a critical role in the maintenance of epithelial barrier function. Impaired TJ structures are observed in patients with asthma, atopic dermatitis and nasal allergy; therefore, the dysfunction of epithelial barriers might be involved in the initiation or progression of allergic diseases...
November 14, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/29147496/markov-chain-based-acute-effect-estimation-of-air-pollution-on-elder-asthma-hospitalization
#2
Li Luo, Fengyi Zhang, Wei Zhang, Lin Sun, Chunyang Li, Debin Huang, Gao Han, Bin Wang
Background: Asthma caused substantial economic and health care burden and is susceptible to air pollution. Particularly, when it comes to elder asthma patient (older than 65), the phenomenon is more significant. The aim of this study is to investigate the Markov-based acute effects of air pollution on elder asthma hospitalizations, in forms of transition probabilities. Methods: A retrospective, population-based study design was used to assess temporal patterns in hospitalizations for asthma in a region of Sichuan province, China...
2017: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29144419/air-pollution-and-dispensed-medications-for-asthma-and-possible-effect-modifiers-related-to-mental-health-and-socio-economy-a-longitudinal-cohort-study-of-swedish-children-and-adolescents
#3
Anna Oudin, Lennart Bråbäck, Daniel Oudin Åström, Bertil Forsberg
It has been suggested that children that are exposed to a stressful environment at home have an increased susceptibility for air pollution-related asthma. The aim here was to investigate the association between air pollution exposure and asthma, and effect modification by mental health and by socio-economic status (as markers of a stressful environment). All individuals under 18 years of age in four Swedish counties during 2007 to 2010 (1.2 million people) were included. The outcome was defined as dispensing at least two asthma medications during follow up...
November 16, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29130366/autophagy-and-inflammation-in-chronic-respiratory-disease
#4
Alexandra C Racanelli, Sarah Ann Kikkers, Augustine M K Choi, Suzanne M Cloonan
Persistent inflammation within the respiratory tract underlies the pathogenesis of numerous chronic pulmonary diseases including chronic obstructive pulmonary disease, asthma and pulmonary fibrosis. Chronic inflammation in the lung may arise from a combination of genetic susceptibility and environmental influences, including exposure to microbes, particles from the atmosphere, irritants, pollutants, allergens and toxic molecules. To this end, an immediate, strong and highly regulated inflammatory defense mechanism is needed for the successful maintenance of homeostasis within the respiratory system...
November 13, 2017: Autophagy
https://www.readbyqxmd.com/read/29128032/acute-effects-of-ambient-air-pollution-on-lower-respiratory-infections-in-hanoi-children-an-eight-year-time-series-study
#5
Nguyen Thi Trang Nhung, Christian Schindler, Tran Minh Dien, Nicole Probst-Hensch, Laura Perez, Nino Künzli
BACKGROUND: Lower respiratory diseases are the most frequent causes of hospital admission in children worldwide, particularly in developing countries. Daily levels of air pollution are associated with lower respiratory diseases, as documented in many time-series studies. However, investigations in low-and-middle-income countries, such as Vietnam, remain sparse. OBJECTIVE: This study investigated the short-term association of ambient air pollution with daily counts of hospital admissions due to pneumonia, bronchitis and asthma among children aged 0-17 in Hanoi, Vietnam...
January 2018: Environment International
https://www.readbyqxmd.com/read/29122888/tnf-stimulated-gene-6-promotes-formation-of-hyaluronan-inter-%C3%AE-inhibitor-heavy-chain-complexes-necessary-for-ozone-induced-airway-hyperresponsiveness
#6
Vandy P Stober, Collin G Johnson, Alana Majors, Mark E Lauer, Valbona Cali, Ronald J Midura, Hans-Georg Wisniewski, Mark A Aronica, Stavros Garantziotis
Exposure to pollutants, such as ozone, exacerbates airway inflammation and hyperresponsiveness (AHR). TNF-stimulated gene 6 (TSG-6) is required to transfer inter-α-inhibitor heavy chains (HC) to hyaluronan (HA), facilitating HA receptors binding. TSG-6 is necessary for AHR in allergic asthma, because it facilitates the development of a pathological HA-HC matrix. However, the role of TSG-6 in acute airway inflammation is not well understood. Here, we hypothesized that TSG-6 is essential for the development of HA- and ozone-induced AHR...
November 9, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29122336/can-environmental-pollution-cause-asthma
#7
María Jesús Cruz, Christian Romero-Mesones, Xavier Muñoz
No abstract text is available yet for this article.
November 6, 2017: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/29118577/associations-between-occupational-inhalation-risks-and-feno-levels-in-airway-obstruction-patients-results-from-the-national-health-and-nutrition-examination-survey-2007-2012
#8
Yi-Chih Huang, Mei-Chen Yang
Purpose: To investigate associations between occupational inhalation risks and fractional exhaled nitric oxide (FeNO) levels in patients with chronic obstructive pulmonary disease (COPD). Patients and methods: Data of 16,486 subjects who had undergone spirometry with pre-bronchodilator and post-bronchodilator lung function assessment were retrieved from the National Health and Nutrition Examination Survey, 2007-2012 database. After excluding 2,638 subjects with missing spirometry values, data of 13,336 subjects were included for analysis...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29117118/diet-and-asthma-is-it-time-to-adapt-our-message
#9
REVIEW
Laurent Guilleminault, Evan J Williams, Hayley A Scott, Bronwyn S Berthon, Megan Jensen, Lisa G Wood
Asthma is a chronic respiratory disorder which is associated with airway inflammation. Environmental factors, in association with genetic susceptibility, play a critical role in asthma pathophysiology. Inhaled allergens, smoke exposure, indoor and outdoor air pollution are common triggers of asthma symptoms. Although the role of diet has clearly established mechanisms in diseases such as cardiovascular disease, type 2 diabetes, and cancer, it is not commonly identified as a causal factor in asthma. However, some dietary patterns, such as the Western diet, which includes a high intake of refined grains, processed and red meats, and desserts, have pro-inflammatory effects...
November 8, 2017: Nutrients
https://www.readbyqxmd.com/read/29106951/localized-real-time-information-on-outdoor-air-quality-at-kindergartens-in-oslo-norway-using-low-cost-sensor-nodes
#10
Nuria Castell, Philipp Schneider, Sonja Grossberndt, Mirjam F Fredriksen, Gabriela Sousa-Santos, Mathias Vogt, Alena Bartonova
In Norway, children in kindergartens spend significant time outdoors under all weather conditions, and there is thus a natural concern about the quality of outdoor air. It is well known that air pollution is associated with a wide variety of adverse health impacts for children, with greater impact on children with asthma. Especially during winter and spring, kindergartens in Oslo that are situated close to streets with busy traffic, or in areas where wood burning is used for house heating, can experience many days with bad air quality...
October 26, 2017: Environmental Research
https://www.readbyqxmd.com/read/29102883/acute-respiratory-symptoms-associated-with-short-term-fluctuations-in-ambient-pollutants-among-schoolchildren-in-durban-south-africa
#11
Graciela Mentz, Thomas G Robins, Stuart Batterman, Rajen N Naidoo
Ambient air pollution has been associated with adverse respiratory outcomes, especially among children with asthma. This study reports on associations between daily ambient air pollutant concentrations and the respiratory symptoms of schoolchildren living in Durban, South Africa. This city is Africa's busiest port and a key hub for imported crude oil and exported refined petroleum and petrochemical products, and it experiences a mixture of air pollutants that reflects emissions from industry, traffic and biomass burning...
November 2, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29094021/the-asthma-and-chronic-obstructive-pulmonary-disease-overlap-syndrome-in-tertiary-care-setting-thailand
#12
Theerasuk Kawamatawong, Sanruethai Charoenniwassakul, Ticha Rerkpattanapipat
Background: Asthma and chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) is an increasingly recognized clinical entity. ACOS significantly impacts on patient outcome compared to isolated asthma or COPD. However, ACOS definition and diagnosis criteria have not been well standardized. ACOS prevalence and clinical features in Thailand has never been studied. Objective: To investigate the prevalence and clinical features of ACOS compared to isolated asthma or COPD among patients with clinician-diagnosis of obstructive airway diseases...
October 2017: Asia Pacific Allergy
https://www.readbyqxmd.com/read/29081678/spatially-modeling-the-effects-of-meteorological-drivers-of-pm2-5-in-the-eastern-united-states-via-a-local-linear-penalized-quantile-regression-estimator
#13
Brook T Russell, Dewei Wang, Christopher S McMahan
Fine particulate matter (PM2.5) poses a significant risk to human health, with long-term exposure being linked to conditions such as asthma, chronic bronchitis, lung cancer, atherosclerosis, etc. In order to improve current pollution control strategies and to better shape public policy, the development of a more comprehensive understanding of this air pollutant is necessary. To this end, this work attempts to quantify the relationship between certain meteorological drivers and the levels of PM2.5. It is expected that the set of important meteorological drivers will vary both spatially and within the conditional distribution of PM2...
August 2017: Environmetrics
https://www.readbyqxmd.com/read/29074540/traffic-related-air-pollution-exposure-over-a-5-year-period-is-associated-with-increased-risk-of-asthma-and-poor-lung-function-in-middle-age
#14
Gayan Bowatte, Bircan Erbas, Caroline J Lodge, Luke D Knibbs, Lyle C Gurrin, Guy B Marks, Paul S Thomas, David P Johns, Graham G Giles, Jennie Hui, Martine Dennekamp, Jennifer L Perret, Michael J Abramson, E Haydn Walters, Melanie C Matheson, Shyamali C Dharmage
Current evidence concerning the impact of exposure to traffic-related air pollution (TRAP) on adult respiratory morbidity mainly comes from cross-sectional studies. We sought to establish more robust measures of this association and potential gene-environment interactions using longitudinal data from an established cohort study.Associations between measures of TRAP (nitrogen dioxide (NO2) and distance to major roads) and wheeze, asthma prevalence and lung function were investigated in participants of the Tasmanian Longitudinal Health Study at 45- and 50-year follow-ups...
October 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29057259/association-between-exposure-to-traffic-related-air-pollution-and-prevalence-of-allergic-diseases-in-children-seoul-korea
#15
Seon-Ju Yi, Changwoo Shon, Kyung-Duk Min, Hwan-Cheol Kim, Jong-Han Leem, Ho-Jang Kwon, Soyoung Hong, KyooSang Kim, Sun-Young Kim
Although there has been suggestive evidence of the association between TRAP and ADs, findings remained inconsistent possibly due to limited population. We investigated the association between TRAP and ADs in a large population of children with rich spatial coverage and expanded age span in Seoul, Korea. TRAP exposures were estimated by categorized proximity to the nearest major road (≤150, 150-300, 300-500, and >500 m) and density of major roads within 300 meters from children's residences. We estimated the association between two TRAP exposures and three ADs using generalized mixed model after adjusting for individual characteristics...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29048385/disease-and-health-inequalities-attributable-to-air-pollutant-exposure-in-detroit-michigan
#16
Sheena E Martenies, Chad W Milando, Guy O Williams, Stuart A Batterman
The environmental burden of disease is the mortality and morbidity attributable to exposures of air pollution and other stressors. The inequality metrics used in cumulative impact and environmental justice studies can be incorporated into environmental burden studies to better understand the health disparities of ambient air pollutant exposures. This study examines the diseases and health disparities attributable to air pollutants for the Detroit urban area. We apportion this burden to various groups of emission sources and pollutants, and show how the burden is distributed among demographic and socioeconomic subgroups...
October 19, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29044495/urban-particulate-matter-stimulation-of-human-dendritic-cells-enhances-priming-of-na%C3%A3-ve-cd8-t-lymphocytes
#17
Paul E Pfeffer, Tzer R Ho, Elizabeth H Mann, Frank J Kelly, Maria Sehlstedt, Jamshid Pourazar, Rosamund E Dove, Thomas Sandstrom, Ian S Mudway, Catherine M Hawrylowicz
Epidemiological studies have consistently shown associations between elevated concentrations of urban particulate matter (UPM) air pollution and exacerbations of asthma and COPD, which are both associated with viral respiratory infections. The effects of urban PM on dendritic cell (DC) stimulated CD4 T lymphocytes have been investigated previously, however little work has focused on CD8 T lymphocyte responses despite their importance in anti-viral immunity. To address this, we examined the effects of UPM on DC-stimulated naïve CD8 T cell responses...
October 16, 2017: Immunology
https://www.readbyqxmd.com/read/29043427/ambient-air-pollution-and-emergency-department-visits-for-asthma-in-erie-county-new-york-2007-2012
#18
Jessica Castner, Lingfei Guo, Yong Yin
PURPOSE: 8% of the US population has asthma. Air pollution is linked to exacerbation in susceptible individuals. The objective was to identify air pollutants that increased the risk of asthma emergency department visits during a time wherein a polluting factory was criminally convicted, changing local air pollutant levels. METHODS: An ecological time-series design used a daily count of asthma emergency visits from 2007 to 2012 as the dependent variable. Independent variables air pollutants (NO2, PM2...
October 17, 2017: International Archives of Occupational and Environmental Health
https://www.readbyqxmd.com/read/29037301/asthma-symptoms-among-chinese-children-the-role-of-ventilation-and-pm10-exposure-at-school-and-home
#19
X-J Fan, C Yang, L Zhang, Q Fan, T Li, X Bai, Z-H Zhao, X Zhang, D Norback
SETTING: Respiratory symptoms in relation to environment in Taiyuan, China. OBJECTIVE: To study associations between school/home exposure and prevalence of respiratory symptoms and self-reported respiratory infections (RIs) among students. DESIGN: A total of 2134 pupils from 10 schools answered a questionnaire; air pollution at school was measured. RESULTS: The prevalence of current wheeze, daytime attacks of breathlessness, nocturnal cough, nocturnal respiratory symptoms and RI was respectively 4...
November 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29022096/the-association-between-ambient-temperature-and-childhood-asthma-a-systematic-review
#20
REVIEW
Zhiwei Xu, James Lewis Crooks, Janet Mary Davies, Al Fazal Khan, Wenbiao Hu, Shilu Tong
The objectives of this study are to review available information on the association between ambient temperature and childhood asthma, and to elucidate the possible underlying mechanisms of this relationship. A systematic review was conducted based on the papers retrieved from four databases, including PubMed, ProQuest, ScienceDirect, and Scopus. Papers examining the association of absolute temperature or temperature variation with childhood asthma published from 1 January 2000 to 31 December 2016 were included...
October 11, 2017: International Journal of Biometeorology
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