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asthma and pollution

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https://www.readbyqxmd.com/read/28321937/ultrafine-particles-and-black-carbon-personal-exposures-in-asthmatic-and-non-asthmatic-children-at-school-age
#1
Pau Pañella, Maribel Casas, David Donaire-Gonzalez, Raquel Garcia-Esteban, Oliver Robinson, Antònia Valentín, John Gulliver, Isabelle Momas, Mark Nieuwenhuijsen, Martine Vrijheid, Jordi Sunyer
Traffic-related air pollution (TRAP) exposure during childhood is associated with asthma; however, the contribution of the different TRAP pollutants in each microenvironment (home, school, transportation, others) in asthmatic and non-asthmatic children is unknown. Daily (24 h) personal black carbon (BC), ultrafine particles (UFP), and alveolar lung deposited surface area (LDSA) individual exposure measurements were obtained from 100 children (29 past and 21 current asthmatics, 50 non-asthmatics) aged 9±0.7 years from the INMA-Sabadell cohort (Catalonia, Spain)...
March 20, 2017: Indoor Air
https://www.readbyqxmd.com/read/28321701/burden-of-disease-attributed-to-ambient-pm2-5-and-pm10-exposure-in-190-cities-in-china
#2
Kamal Jyoti Maji, Mohit Arora, Anil Kumar Dikshit
Particulate air pollution is becoming a serious public health concern in urban cities of China. Association of disability-adjusted life years (DALYs) and economic loss with air pollution-related health effects demand quantitative analysis for correctional measures in air quality. This study applies an epidemiology-based exposure-response function to obtain the quantitative estimate of health impact of particulate matter PM2.5 and PM10 across 190 cities of China during years 2014-2015. The annual average concentration of PM2...
March 20, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28319180/effect-of-outdoor-air-pollution-on-asthma-exacerbations-in-children-and-adults-systematic-review-and-multilevel-meta-analysis
#3
Pablo Orellano, Nancy Quaranta, Julieta Reynoso, Brenda Balbi, Julia Vasquez
BACKGROUND: Several observational studies have suggested that outdoor air pollution may induce or aggravate asthma. However, epidemiological results are inconclusive due to the presence of numerous moderators which influence this association. The goal of this study was to assess the relationship between outdoor air pollutants and moderate or severe asthma exacerbations in children and adults through a systematic review and multilevel meta-analysis. MATERIAL AND METHODS: We searched studies published in English on PubMed, Scopus, and Google Scholar between January 2000 and October 2016...
2017: PloS One
https://www.readbyqxmd.com/read/28304360/traffic-related-air-pollution-and-childhood-asthma-recent-advances-and-remaining-gaps-in-the-exposure-assessment-methods
#4
REVIEW
Haneen Khreis, Mark J Nieuwenhuijsen
Background: Current levels of traffic-related air pollution (TRAP) are associated with the development of childhood asthma, although some inconsistencies and heterogeneity remain. An important part of the uncertainty in studies of TRAP-associated asthma originates from uncertainties in the TRAP exposure assessment and assignment methods. In this work, we aim to systematically review the exposure assessment methods used in the epidemiology of TRAP and childhood asthma, highlight recent advances, remaining research gaps and make suggestions for further research...
March 17, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28300662/diisononyl-phthalate-induces-asthma-via-modulation-of-th1-th2-equilibrium
#5
Yun-Ho Hwang, Man-Jeong Paik, Sung-Tae Yee
Diisononyl phthalate (DINP), a member of the phthalate family, is used to plasticize polyvinyl chloride (PVC). This chemical is known to enhance airway inflammation in the OVA-induced asthma model (adjuvant effects) and aggravate allergic dermatitis. Moreover, DINP enhances the production of interleukin-4 in activated CD4(+) T cells. However, the effect of DINP itself on the differentiation of naïve CD4(+) T cells into T helper cells (Th1/Th2) in vitro and allergic asthma in vivo has not yet been studied. In this study, DINP was shown to suppress the polarization of Th1 and enhance the polarization of Th2 from naïve CD4(+) T cells in vitro...
March 11, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28293925/genetic-signatures-of-asthma-exacerbation
#6
REVIEW
Heung Woo Park, Kelan G Tantisira
Asthma exacerbation (AE) usually denotes worsening of asthma symptoms that requires intense management to prevent further deterioration. AE has been reported to correlate with clinical and demographic factors, such as race, gender, and treatment compliance as well as environmental factors, such as viral infection, smoking, and air pollution. In addition, recent observations suggest that there are likely to be genetic factors specific to AE. Understanding genetic factors specific to AE is essential to develop therapy tailored for exacerbation-prone asthma...
May 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28286602/climate-change-allergy-and-asthma-and-the-role-of-tropical-forests
#7
REVIEW
Gennaro D'Amato, Carolina Vitale, Nelson Rosario, Herberto Josè Chong Neto, Deborah Carla Chong-Silva, Francisco Mendonça, Josè Perini, Loraine Landgraf, Dirceu Solé, Mario Sánchez-Borges, Ignacio Ansotegui, Maria D'Amato
BACKGROUND: Tropical forests cover less than 10 per cent of all land area (1.8 × 107 km(2)) and over half of the tropical-forest area (1.1 × 107 Km(2)) is represented by humid tropical forests (also called tropical rainforests). The Amazon basin contains the largest rainforest on Earth, almost 5.8 million km(2), and occupies about 40% of South America; more than 60% of the basin is located in Brazil and the rest in Bolivia, Colombia, Ecuador, French Guiana, Guyana, Peru, Suriname and Venezuela...
2017: World Allergy Organization Journal
https://www.readbyqxmd.com/read/28284326/effects-of-particulate-matter-on-respiratory-disease-and-the-impact-of-meteorological-factors-in-busan-korea
#8
Eun-Jung Jo, Woo-Seop Lee, Hyun-Young Jo, Chang-Hoon Kim, Jung-Seop Eom, Jeong-Ha Mok, Mi-Hyun Kim, Kwangha Lee, Ki-Uk Kim, Min-Ki Lee, Hye-Kyung Park
BACKGROUND: Both air pollution and weather impact hospitalization for respiratory diseases. However, few studies have investigated the contribution of weather to hospitalization related to the adverse effects of air pollution. This study analyzed the effects of particulate matter (PM) on daily respiratory-related hospital admissions, taking into account meteorological factors. METHODS: Daily hospital admissions for respiratory diseases (acute bronchitis, allergic rhinitis, and asthma) between 2007 and 2010 were extracted from the National Health Insurance Corporation, Korea...
March 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28283935/application-of-multivariate-statistical-analysis-in-the-pollution-and-health-risk-of-traffic-related-heavy-metals
#9
Mohammad Ebqa'ai, Bashar Ibrahim
This study aims to analyse the heavy metal pollutants in Jeddah, the second largest city in the Gulf Cooperation Council with a population exceeding 3.5 million, and many vehicles. Ninety-eight street dust samples were collected seasonally from the six major roads as well as the Jeddah Beach, and subsequently digested using modified Leeds Public Analyst method. The heavy metals (Fe, Zn, Mn, Cu, Cd, and Pb) were extracted from the ash using methyl isobutyl ketone as solvent extraction and eventually analysed by atomic absorption spectroscopy...
March 10, 2017: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/28268242/tuberculosis-associated-chronic-obstructive-pulmonary-disease
#10
REVIEW
Malay Sarkar, Srinivas Gowda, Irappa Madabhavi, Kushal Dogra
OBJECTIVES: Reviewed the epidemiology, clinical characteristics, mechanisms and treatment of tuberculosis associated chronic obstructive pulmonary disease. DATA SOURCE: We searched PubMed, EMBASE and the CINAHL from inception to June 2016. We used the following search terms: Tuberculosis, COPD, Tuberculosis associated COPD etc. All types of study were chosen. RESULTS AND CONCLUSION: Chronic obstructive pulmonary disease (COPD) and tuberculosis are significant public health problems, particularly in developing countries...
March 7, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28266271/update-on-interventions-in-prevention-and-treatment-of-pediatric-asthma
#11
Marcello Lanari, Paolo Bottau, Elisabetta Calamelli
BACKGROUND: Asthma represents a worldwide health problem with a strong morbidity and a major impact on the health care system. Multiple efforts have been made towards the development of new strategies of prevention and treatment of this disorder. In the light of this the present review of the literature aimed at summarizing the latest advances in prevention and treatment of pediatric asthma with a focus on the most effective options of interventions during the first stages of life. METHODS: References were identified by searches of PubMed...
March 3, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28265480/proximity-to-a-major-road-and-plasma-cytokines-in-school-aged-children
#12
Franziska Rosser, Erick Forno, John Brehm, Yueh-Ying Han, Nadia Boutaoui, Angel Colón-Semidey, María Alvarez, Edna Acosta-Pérez, Kristen S Kurland, John F Alcorn, Glorisa Canino, Juan C Celedón
Traffic-related air pollution (TRAP) may affect immune responses, including those in the TH2 and TH17 pathways. To examine whether TRAP is associated with plasma level of TH17-, TH1-, and TH2-related cytokines in children with and without asthma, a cross-sectional study of 577 children (ages 6-14 years) with (n = 294) and without (n = 283) asthma in San Juan (Puerto Rico) was performed. Residential distance to a major road was estimated using geocoded home addresses for study participants. A panel of 14 cytokines, enriched for the TH17 pathway, was measured in plasma...
September 1, 2016: Pediatric Allergy, Immunology, and Pulmonology
https://www.readbyqxmd.com/read/28245275/the-effect-of-size-segregated-ambient-particulate-matter-on-th1-th2-like-immune-responses-in-mice
#13
Kuo-Liang Huang, Szu-Yuan Liu, Charles C K Chou, Yi-Hsin Lee, Tsun-Jen Cheng
BACKGROUND: Particulate matter (PM) has been associated with increased pulmonary and cardiovascular mortality and morbidity. Additionally, PM is known to exacerbate asthma. However, whether ambient PM exposure contributes to the onset of asthma, especially in non-atopic children and adults, is less conclusive. The current study aimed to evaluate the effects of size-fractioned PM on lung immune responses in healthy BALB/c mice. METHODS AND PRINCIPAL FINDINGS: We collected PM10, PM2...
2017: PloS One
https://www.readbyqxmd.com/read/28239256/outdoor-environment-and-pediatric-asthma-an-update-on-the-evidence-from-north-america
#14
REVIEW
Jenna Pollock, Lu Shi, Ronald W Gimbel
Introduction. The evidence about the association between asthma and outdoor environmental factors has been inadequate for certain allergens. Even less is known about how these associations vary across seasons and climate regions. We reviewed recent literature from North America for research related to outdoor environmental factors and pediatric asthma, with attention to spatial-temporal variations of these associations. Method. We included indexed literature between years 2010 and 2015 on outdoor environmental factors and pediatric asthma, by searching PubMed...
2017: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/28222232/dietary-total-antioxidant-capacity-in-early-school-age-and-subsequent-allergic-disease
#15
Anna Gref, Susanne Rautiainen, Olena Gruzieva, Niclas Håkansson, Inger Kull, Göran Pershagen, Magnus Wickman, Alicja Wolk, Erik Melén, Anna Bergström
BACKGROUND: Dietary antioxidant intake has been hypothesized to influence the development of allergic diseases, however, few prospective studies have investigated this association. OBJECTIVE: Our aim was to study the association between total antioxidant capacity (TAC) of the diet at age 8 years and the subsequent development of asthma, rhinitis and sensitization to inhalant allergens between 8 and 16 years, and to assess potential effect modification by known risk factors...
February 21, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28208075/socioeconomic-and-air-pollution-correlates-of-adult-asthma-heart-attack-and-stroke-risks-in-the-united-states-2010-2013
#16
Louis Anthony Tony Cox
Asthma in the United States has become an important public health issue, with many physicians, regulators, and scientists elsewhere expressing concern that criterion air pollutants have contributed to a rising tide of asthma cases and symptoms. This paper studies recent associations (from 2008 to 2012) between self-reported asthma experiences and potential predictors, including age, sex, income, education, smoking, and county-level average annual ambient concentrations of ozone (O3) and fine particulate matter (PM2...
February 14, 2017: Environmental Research
https://www.readbyqxmd.com/read/28207081/can-we-be-too-clean-for-our-own-good-the-hygiene-hypothesis-reviewed
#17
Sheenal Patel, Rebecca Gruchalla
The hygiene hypothesis began as an attempt to explain the relatively rapid rise in atopic diseases. Strachan's early hypothesis regarding the role of family size and exposure to early childhood infections in the development of atopic diseases has clearly evolved to integrate the possible effects of hygiene, eradication of parasitic infections, immunizations, improvements in home heating and ventilation, dust mite exposure, breastfeeding duration, diet, parental smoking, pollution, and exposure to pets and farm animals...
February 1, 2017: Texas Medicine
https://www.readbyqxmd.com/read/28203435/recent-developments-in-the-role-of-reactive-oxygen-species-in-allergic-asthma
#18
REVIEW
Jingjing Qu, Yuanyuan Li, Wen Zhong, Peisong Gao, Chengping Hu
Allergic asthma has a global prevalence, morbidity, and mortality. Many environmental factors, such as pollutants and allergens, are highly relevant to allergic asthma. The most important pathological symptom of allergic asthma is airway inflammation. Accordingly, the unique role of reactive oxygen species (ROS) had been identified as a main reason for this respiratory inflammation. Many studies have shown that inhalation of different allergens can promote ROS generation. Recent studies have demonstrated that several pro-inflammatory mediators are responsible for the development of allergic asthma...
January 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28193558/allergic-disease-associations-with-regional-and-localized-estimates-of-air-pollution
#19
Amy A Schultz, Jamie J Schauer, Kristen Mc Malecki
BACKGROUND: Exposure to multiple types of air pollution may contribute to and exacerbate allergic diseases including asthma and wheezing. However, few studies have examined chronic air pollution exposure and allergic disease outcomes among an adult population. Associations between potential estimates of annual average fine particulate matter (PM2.5), traffic related air pollution, and industrial source air emissions and three allergic disease outcomes (asthma, allergies and wheezing) were examined in a state-wide general population of adults...
February 10, 2017: Environmental Research
https://www.readbyqxmd.com/read/28183433/mechanisms-of-the-development-of-allergy-medall-introducing-novel-concepts-in-allergy-phenotypes
#20
REVIEW
Josep M Anto, Jean Bousquet, Mubeccel Akdis, Charles Auffray, Thomas Keil, Isabelle Momas, Dirkje S Postma, Rudolf Valenta, Magnus Wickman, Anne Cambon-Thomsen, Tari Haahtela, Bart N Lambrecht, Karin C Lodrup Carlsen, Gerard H Koppelman, Jordi Sunyer, Torsten Zuberbier, Isabelle Annesi-Maesano, Albert Arno, Carsten Bindslev-Jensen, Giuseppe De Carlo, Francesco Forastiere, Joachim Heinrich, Marek L Kowalski, Dieter Maier, Erik Melén, Henriette A Smit, Marie Standl, John Wright, Anna Asarnoj, Marta Benet, Natalia Ballardini, Judith Garcia-Aymerich, Ulrike Gehring, Stefano Guerra, Cynthia Hohmann, Inger Kull, Christian Lupinek, Mariona Pinart, Ingebjorg Skrindo, Marit Westman, Delphine Smagghe, Cezmi Akdis, Niklas Andersson, Claus Bachert, Stephane Ballereau, Ferran Ballester, Xavier Basagana, Anna Bedbrook, Anna Bergstrom, Andrea von Berg, Bert Brunekreef, Emilie Burte, Kai-Hakon Carlsen, Leda Chatzi, Jonathan M Coquet, Mirela Curin, Pascal Demoly, Esben Eller, Maria Pia Fantini, Leena von Hertzen, Vergard Hovland, Benedicte Jacquemin, Jocelyne Just, Theresa Keller, Renata Kiss, Manolis Kogevinas, Sibylle Koletzko, Susanne Lau, Irina Lehmann, Nicolas Lemonnier, Mika Mäkelä, Jordi Mestres, Peter Mowinckel, Rachel Nadif, Martijn C Nawijn, Johan Pellet, Isabelle Pin, Daniela Porta, Fanny Rancière, Emmanuelle Rial-Sebbag, Yvan Saeys, Martijn J Schuijs, Valerie Siroux, Christina G Tischer, Mathies Torrent, Raphaelle Varraso, Kalus Wenzel, Cheng-Jian Xu
Asthma, rhinitis, and eczema are complex diseases with multiple genetic and environmental factors interlinked through IgE-associated and non-IgE-associated mechanisms. Mechanisms of the Development of ALLergy (MeDALL; EU FP7-CP-IP; project no: 261357; 2010-2015) studied the complex links of allergic diseases at the clinical and mechanistic levels by linking epidemiologic, clinical, and mechanistic research, including in vivo and in vitro models. MeDALL integrated 14 European birth cohorts, including 44,010 participants and 160 cohort follow-ups between pregnancy and age 20 years...
February 2017: Journal of Allergy and Clinical Immunology
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