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asthma and pollution

Mei Mei, Haojun Song, Lina Chen, Bin Hu, Ru Bai, Diandou Xu, Ying Liu, Yuliang Zhao, Chunying Chen
BACKGROUND: Epidemiological studies have suggested that elevated levels of air pollution contribute to an increased incidence or severity of asthma. Although late-onset adult asthma seems to be more attributable to environmental risk factors, limited data is available on the impact of early-life exposure to size-fractionated ambient particulate matter (PM) on asthma in adults. We aimed to determine the effect on the development and exacerbation of asthma in the adult after the mice were exposed as juveniles to three size-fractionated ambient particulates collected from Beijing...
March 14, 2018: Particle and Fibre Toxicology
Dan Norbäck, Chan Lu, Juan Wang, Yinping Zhang, Baizhan Li, Zhuohui Zhao, Chen Huang, Xin Zhang, Hua Qian, Yuexia Sun, Jan Sundell, Qihong Deng
BACKGROUND: Few data exist on asthma and rhinitis across China in relation to indoor and outdoor air pollution, climate and socioeconomic factors. The main aim was to study associations between asthma, rhinitis and current respiratory symptoms among pre-school children across China and selected indoor and outdoor exposure and indicators of socio-economic status (SES) in mutually adjusted models. METHODS: Chinese children (3-6 yr.) (n = 39,782) were recruited from randomly selected day care centres in seven cities in China...
March 9, 2018: Environment International
Yijun Lin, Dimitrios Stripelis, Yao-Yi Chiang, José Luis Ambite, Rima Habre, Fan Pan, Sandrah P Eckel
Air quality models are important for studying the impact of air pollutant on health conditions at a fine spatiotemporal scale. Existing work typically relies on area-specific, expert-selected attributes of pollution emissions (e,g., transportation) and dispersion (e.g., meteorology) for building the model for each combination of study areas, pollutant types, and spatiotemporal scales. In this paper, we present a data mining approach that utilizes publicly available OpenStreetMap (OSM) data to automatically generate an air quality model for the concentrations of fine particulate matter less than 2...
November 2017: Proceedings of the ... ACM SIGSPATIAL International Conference on Advances in Geographic Information Systems: ACM GIS
Lucy Chambers, Joanne Finch, Karen Edwards, Antoine Jeanjean, Roland Leigh, Sherif Gonem
BACKGROUND: There is evidence that air pollution increases the risk of asthma hospitalisations and healthcare utilisation, but the effects on day-to-day asthma control are not fully understood. OBJECTIVE: We undertook a prospective single-centre panel study to test the hypothesis that personal air pollution exposure is associated with asthma symptoms, lung function and airway inflammation. METHODS: Thirty-two patients with a clinical diagnosis of asthma were provided with a personal air pollution monitor (Cairclip NO2 /O3 ) which was kept on or around their person throughout the 12-week follow-up period...
March 11, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
Sotiris Vardoulakis, Nicholas Osborne
No abstract text is available yet for this article.
March 8, 2018: Archives of Disease in Childhood
Lorenzo Cecchi, Gennaro D'Amato, Isabella Annesi-Maesano
Allergies are complex diseases that result from interactions between multiple genetic and environmental factors. However, the increase in allergies observed in the past decades is explained exclusively by environmental changes occurring in the same period. Presently, the exposome, the totality of specific and nonspecific external environmental exposures (external exposome) to which a subject is exposed from preconception onward and their consequences at the organ and cell levels (internal exposome), is being considered to explain the inception, development, and exacerbations of allergic diseases...
March 2018: Journal of Allergy and Clinical Immunology
Ahra Kim, Gina Lim, Inbo Oh, Yangho Kim, Taehoon Lee, Jiho Lee
BACKGROUND: Perinatal factors are suspected to have a significant impact on the development of asthma; however, sufficiently powered studies have not been performed to investigate this issue. OBJECTIVE: To evaluate whether perinatal factors and other risk factors have an independent or combined effect on the development of asthma. METHODS: This study involved 3,770 children (mean age 9.1 years, range 5.68-12.16 years; 51.9% boys) who were enrolled in the Elementary School Student Cohort (2009-2014) in Ulsan University Hospital (Ulsan, Korea)...
March 2018: Annals of Allergy, Asthma & Immunology
Chih-Ming Weng, Meng-Jung Lee, Jung-Re He, Ming-Wei Chao, Chun-Hua Wang, Han-Pin Kuo
IL-17A is implicated in many aspects of pathogenesis of severe asthma, including inducing neutrophilic inflammation, airway hyperresponsiveness, steroid insensitivity and airway remodeling. Diesel exhaust particles (DEP) emission from vehicles has been shown to expand Th17 cells to increase IL-17A release that contributes to DEP-mediated exacerbation of asthma severity. It is not known whether non-immune cells in airways may also release IL-17A in response to DEP exposure. In this study, We found IL-17A expression was upregulated in the epithelium of severe allergic asthma patients from high road traffic pollution areas compared to those in low...
February 27, 2018: Biochemical Pharmacology
Hao Zhang, Yue Niu, Yili Yao, Renjie Chen, Xianghong Zhou, Haidong Kan
The evidence concerning the acute effects of ambient air pollution on various respiratory diseases was limited in China, and the attributable medical expenditures were largely unknown. From 2013 to 2015, we collected data on the daily visits to the emergency- and outpatient-department for five main respiratory diseases and their medical expenditures in Shanghai, China. We used the overdispersed generalized additive model together with distributed lag models to fit the associations of criteria air pollutants with hospital visits, and used the linear models to fit the associations with medical expenditures...
February 28, 2018: International Journal of Environmental Research and Public Health
Allison J Burbank, David B Peden
PURPOSE OF REVIEW: Exposure to air pollutants is linked with poor asthma control in children and represents a potentially modifiable risk factor for impaired lung function, rescue medication use, and increased asthma-related healthcare utilization. Identification of the most relevant pollutants to asthma as well as susceptibility factors and strategies to reduce exposure are needed to improve child health. RECENT FINDINGS: The current available literature supports the association between pollutants and negative asthma outcomes...
April 2018: Current Opinion in Allergy and Clinical Immunology
Laurent Devien, Jonathan Giovannelli, Damien Cuny, Régis Matran, Philippe Amouyel, Sébastien Hulo, Jean Louis Edmé, Luc Dauchet
INTRODUCTION: The objective of the present study was to investigate the relationship between sources of household air pollution, respiratory symptoms and lung function. METHODS: 3039 adults aged from 40 to 65 participated in the 2011-2013 ELISABET cross-sectional survey in northern France. Lung function was measured using spirometry. During a structured interview, respiratory symptoms, household fuels, exposure to moulds, and use of ventilation were recorded on a questionnaire...
February 24, 2018: Environmental Research
Ashley A Lowe, Bruce Bender, Andrew H Liu, Teshia Solomon, Aaron Kobernick, Wayne Morgan, Lynn B Gerald
RATIONALE: Navajo children living on the reservation have high rates of asthma prevalence and severity. Environmental influences may contribute to asthma on the Navajo Nation and are inadequately understood. OBJECTIVES: We performed a comprehensive, integrative literature review to determine the environmental factors that may contribute to increased asthma prevalence and severity among Navajo children living on the reservation. METHODS: A systematic search was conducted in 4 databases regarding the environmental risk factors for asthma in Navajo children living on the reservation...
February 27, 2018: Annals of the American Thoracic Society
Kristina Trnjar, Sanja Pintarić, Marko Mornar Jelavić, Višnja Nesek, Jelena Ostojić, Sanja Pleština, Aljoša Šikić, Hrvoje Pintarić
The aim of the study was to investigate the unknown effect of air pollutants on the occurrence or deterioration of respiratory diseases in the area with a humid continental climate. This retrospective study included 5868 patients with respiratory symptomatology (upper respiratory tract infection (URTI), pneumonia, acute bronchitis, chronic obstructive pulmonary disease (COPD), and asthma) admitted to emergency department (ED). The number of patients, values of meteorological parameters (mean daily values of air temperature pressure and relative humidity) and concentrations of air pollution particles (≤10 μm (PM10), ozone (O3) and nitrogen dioxide (NO2)) were collected during a two-year ( July 2008 - June 2010) period...
June 2017: Acta Clinica Croatica
Yoomie Lee, Nathan Rabinovitch
No abstract text is available yet for this article.
February 23, 2018: Annals of Allergy, Asthma & Immunology
Jillian R Palumbo, Shao Lin, Ziqiang Lin, Iulia A Neamtiu, Wangjian Zhang, Eva Csobod, Eugen S Gurzau
School environment may have an impact on children's health, but few studies have focused on indoor comfort factors such as temperature, humidity, and noise in relation with potential effects on children's health. Our cross-sectional study used data from the European Schools Indoor Pollution and Health Observatory Network in Europe (SINPHONIE) project to assess children's allergy, asthma-like symptoms, and flu-like symptoms in relation with classroom comfort and environmental factors. The study used self-reported data from three questionnaires to identify classroom conditions and student health outcomes for 280 students...
February 22, 2018: Environmental Science and Pollution Research International
Yungling Leo Lee, Jing-Huei Chen, Chi-Min Wang, Mei-Ling Chen, Bing-Fang Hwang
Interleukin-13(IL-13) might play an important role in driving aggregate bronchitic symptoms pathogenesis. However, none of the studies assessed the interaction between air pollutants exposure and IL-13 gene on the risk of aggregate bronchitic symptoms in non-asthma children. To assess the independent and joint effects of the exposure to air pollution and IL-13 haplotypes on the risk of aggregate bronchitic symptoms, we conducted a cross-sectional study and focused on non-asthma children. The study population consisted of 2944 children...
February 12, 2018: EBioMedicine
Sam E Wing, Gretchen Bandoli, Donatello Telesca, Jason G Su, Beate Ritz
BACKGROUND: Chronic health effects of traffic-related air pollution, like nitrogen dioxide (NO2 ), are well-documented. Animal models suggested that NO2 exposures dysregulate cortisol function. OBJECTIVES: We evaluated the association between traffic-related NO2 exposure and adolescent human cortisol concentrations, utilizing measures of the cortisol diurnal slope. METHODS: 140 adolescents provided repeated salivary cortisol samples throughout one day...
February 15, 2018: Environmental Research
Ana Teresa Romero-Calderón, Hortensia Moreno-Macías, Joel David Francisco Manrique-Moreno, Horacio Riojas-Rodríguez, Yessica Dorín Torres-Ramos, Araceli Montoya-Estrada, Juan José Hicks-Gómez, Benigno Linares-Segovia, Beatriz Cárdenas, Claudia Bárcenas, Albino Barraza-Villarreal
OBJECTIVE.: To assess the association between the air pollutants exposure on markers of oxidative stress and lung function in schoolchildren with and without asthma from Salamanca and Leon Guanajuato, Mexico. MATERIALS AND METHODS: We realized determinations of oxidative stress biomarkers and lung function tests in 314 schoolchildren. Information of air pollutants (O3, SO2, CO, PM2.5 and PM10) were obtained from monitoring stations and multiple linear regression models were run to assess the association...
November 2017: Salud Pública de México
Hui-Ying Tung, Evan Li, Cameron Landers, An Nguyen, Farrah Kheradmand, J Morgan Knight, David B Corry
Allergic asthma is a heterogeneous disorder that defies a unanimously acceptable definition, but is generally recognized through its highly characteristic clinical expression of dyspnea and cough accompanied by clinical data that document reversible or exaggerated airway constriction and obstruction. The generally rising prevalence of asthma in highly industrialized societies despite significant therapeutic advances suggests that the fundamental cause(s) of asthma remain poorly understood. Detailed analyses of both the indoor (built) and outdoor environments continue to support the concept that not only inhaled particulates, especially carbon-based particulate pollution, pollens, and fungal elements, but also many noxious gases and chemicals, especially biologically derived byproducts such as proteinases, are essential to asthma pathogenesis...
February 2018: Seminars in Respiratory and Critical Care Medicine
Andréanne Côté, Julie Turmel, Louis-Philippe Boulet
Transient airway narrowing can occur during or following exercise, a phenomenon called exercise-induced bronchoconstriction (EIB). The main mechanism of EIB is considered to be airway dehydration, resulting from increased ventilation during exercise. In asthma, such water loss causes an increase in airway fluid osmolarity, inducing airway smooth muscle contraction following the release of mediators from airway inflammatory cells. Asthmatics frequently experience EIB, but it may also be observed in others not reporting asthma symptoms, particularly elite endurance athletes...
February 2018: Seminars in Respiratory and Critical Care Medicine
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