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https://www.readbyqxmd.com/read/28801196/prenatal-fine-particulate-exposure-and-early-childhood-asthma-effect-of-maternal-stress-and-fetal-gender
#1
Alison Lee, Hsiao-Hsien Leon Hsu, Yueh-Hsiu Mathilda Chiu, Sonali Bose, Maria José Rosa, Itai Kloog, Ander Wilson, Joel Schwartz, Sheldon Cohen, Brent A Coull, Robert O Wright, Rosalind J Wright
BACKGROUND: The impact of prenatal ambient air pollution on child asthma may be modified by maternal stress, child sex and exposure dose and timing. OBJECTIVE: We prospectively examined associations between co-exposure to prenatal particulate matter with an aerodynamic diameter of less than 2.5 microns (PM2.5) and maternal stress on childhood asthma (n=736). METHODS: Daily PM2.5 exposure during pregnancy was estimated using a validated satellite-based spatio-temporally resolved prediction model...
August 8, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28798526/environmental-pollution-and-allergies
#2
REVIEW
Hirohisa Takano, Ken-Ichiro Inoue
Environmental changes are thought to be the main factor in the rapid increase and worsening of allergic diseases. While there have been significant changes in many environmental factors, including in environments such as residential, health and sanitation, food, and water/soil/atmospheric environments, the root of each of these changes is likely an increase in chemical substances. In fact, various environmental pollutants, such as air pollutants and chemical substances, have been shown to worsen various allergies in experimental studies...
July 2017: Journal of Toxicologic Pathology
https://www.readbyqxmd.com/read/28765821/increased-antioxidant-activity-after-exposure-of-ozone-in-murine-asthma-model
#3
Yang Ki Kim, So My Koo, Kiup Kim, Soo-Taek Uh, Ahnsoo Jang, Choon-Sik Park
BACKGROUND: Ozone is well known as an important component of ambient air pollutants. Ozone can aggravate respiratory symptoms in patients with bronchial asthma, but, not in healthy person. We hypothesized asthma itself may show different response to ozone compared to nonasthma. OBJECTIVE: This study was performed to evaluate the differences of response to ozone between normal and asthmatic mice model in terms of status of oxidant injury and antioxidant activity...
July 2017: Asia Pacific Allergy
https://www.readbyqxmd.com/read/28763386/estimating-the-public-health-impact-of-air-pollution-for-informing-policy-in-the-twin-cities-a-minnesota-tracking-collaboration
#4
Jean E Johnson, David L Bael, Jeannette M Sample, Paula G Lindgren, Dorian L Kvale
OBJECTIVE: The Minnesota Department of Health and the Minnesota Pollution Control Agency used local air pollution and public health data to estimate the impacts of particulate matter and ozone on population health, to identify disparities, and to inform decisions that will improve health. SETTING: While air quality in Minnesota currently meets federal standards, urban communities are concerned about the impact of air pollution on their health. The Twin Cities (Minneapolis-St Paul) metropolitan area includes 7 counties where fine particulate levels and rates of asthma exacerbations are elevated in some communities...
September 2017: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/28757229/prenatal-particulate-matter-exposure-and-wheeze-in-mexican-children-effect-modification-by-prenatal-psychosocial-stress
#5
Maria José Rosa, Allan C Just, Itai Kloog, Ivan Pantic, Lourdes Schnaas, Alison Lee, Sonali Bose, Yueh-Hsiu Mathilda Chiu, Hsiao-Hsien Leon Hsu, Brent Coull, Joel Schwartz, Sheldon Cohen, Martha María Téllez Rojo, Robert O Wright, Rosalind J Wright
BACKGROUND: Air pollution exposure in childhood is associated with greater incidence and exacerbation of asthma, particularly in children whose parents report high levels of psychological stress. However, this interaction has not been completely elucidated in pregnancy. OBJECTIVE: To examine whether the association between prenatal exposure to particulate matter no larger than 2.5 μm in diameter (PM2.5) and wheeze in children is modified by prenatal stress. METHODS: Mexican women were recruited during pregnancy (N = 552)...
July 27, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28757196/air-pollution-and-its-relationship-to-lung-function-among-adolescents-from-taubate-s%C3%A3-o-paulo-brazil
#6
M Froio Toledo, B Mangueira Saraiva-Romanholo, R Carvalho Oliveira, L Ferraz da Silva, D Solé
BACKGROUND: This paper sought to evaluate individual exposure to air pollution by quantifying the carbon in alveolar macrophages (AMs) and its relationship to lung function. We also examined the proximity of participants' residences to the Presidente Dutra highway (PDH) in adolescents with asthma from Taubaté, São Paulo, Brazil. METHODS: This descriptive study examined fifty 13- to 14-year-old adolescents with asthma identified by the International Study of Asthma and Allergies in Childhood (ISAAC) in Taubaté...
July 27, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/28740386/quantum-dots-based-lateral-flow-immunoassay-combined-with-image-analysis-for-semiquantitative-detection-of-ige-antibody-to-mite
#7
Yan Zhao, Qiang Zhang, Qingfeng Meng, Fenglian Wu, Lihua Zhang, Yao Tang, Yuanyuan Guan, Lixin An
Semiquantitative and rapid detection of specific IgE (sIgE) with well clinical relevance to house dust mite (HDM) are promising for prevalence rhinitis and asthma patients due to the increasing air pollution. However, the conventional IgE measurement systems are time-consuming, complicated and require special instruments. Herein, we overcome the above limitations of sIgE to HDM detection system by developing a quantum dot nanobeads-based lateral flow immunoassay and an image analysis procedure. The proposed detection system could semiquantitatively measure the IgE in a linear range of 0...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28737932/ins-and-outs-in-environmental-and-occupational-safety-studies-of-asthma-and-engineered-nanomaterials
#8
Marina A Dobrovolskaia, Michael R Shurin, Valerian E Kagan, Anna A Shvedova
According to the Centers for Disease Control and Prevention, approximately 25 million Americans suffer from asthma. The disease total annual cost is about $56 billion and includes both the direct and indirect costs of medications, hospital stays, missed work, and decreased productivity. Air pollution with xenobiotics, bacterial agents, and industrial nanomaterials, such as carbon nanotubes, contribute to the exacerbation of this condition and are a point of particular attention in environmental toxicology as well as in occupational health and safety research...
July 24, 2017: ACS Nano
https://www.readbyqxmd.com/read/28732014/association-of-time-serial-changes-in-ambient-particulate-matters-pms-with-respiratory-emergency-cases-in-taipei-s-wenshan-district
#9
Jer-Hwa Chang, Shih-Chang Hsu, Kuan-Jen Bai, Shau-Ku Huang, Chin-Wang Hsu
Ambient air pollution poses a significant risk for a group of common and often debilitating respiratory diseases, but its direct impact on cause-specific respiratory diseases using emergency room visit (ERV) as an indicator remains to be fully explored. In this study, we conducted a time-series study of ambient PM2.5, NO2, SO2 and their association with ERV for asthma, COPD and pneumonia in a four-year time span. Relative risks for ERV as per log increase in the level of ambient pollutants with time lags of up to 10 days were calculated, using a generalized additive model of Poisson regression...
2017: PloS One
https://www.readbyqxmd.com/read/28719626/impact-of-respiratory-infections-outdoor-pollen-and-socioeconomic-status-on-associations-between-air-pollutants-and-pediatric-asthma-hospital-admissions
#10
Julie E Goodman, Christine T Loftus, Xiaobin Liu, Ke Zu
BACKGROUND: Epidemiology studies have shown that ambient concentrations of ozone and fine particulate matter (PM2.5) are associated with increased emergency department (ED) visits and hospital admissions (HAs) for asthma. OBJECTIVE: Evaluate the impact of outdoor pollen, respiratory infections, and socioeconomic status (SES) on the associations between ambient ozone and PM2.5 and asthma HAs in New York City. METHODS: Daily ozone, PM2.5, meteorological factors, pollen, and hospitalization records during 1999 to 2009 were obtained for New York City residents...
2017: PloS One
https://www.readbyqxmd.com/read/28713081/gene-polymorphism-of-xenobiotic-detoxification-in-children-with-bronchial-asthma
#11
Liudmila Y Lytvynets
INTRODUCTION: Children are the most susceptible to harmful external factors due to the incomplete development of all functional body systems. The ecological situation the problem of influence of genetic and environmental factors on the pathogenesis of chronic respiratory diseases in children and its investigation is very impotent today. Among it the bronchial asthma is a leader among bronchial and pulmonary diseases caused by the influence of pneumotropic pollutants. The aim of our research was to study the phenotypic characteristics of asthma in Pre-Carpathian children with different types of allelic gene polymorphism of the first phase of xenobiotic detoxification of microsomal epoxide hydrolases (mEPHX1)...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28698523/assessing-the-potential-of-land-use-modification-to-mitigate-ambient-no%C3%A2-and-its-consequences-for-respiratory-health
#12
Meenakshi Rao, Linda A George, Vivek Shandas, Todd N Rosenstiel
Understanding how local land use and land cover (LULC) shapes intra-urban concentrations of atmospheric pollutants-and thus human health-is a key component in designing healthier cities. Here, NO₂ is modeled based on spatially dense summer and winter NO₂ observations in Portland-Hillsboro-Vancouver (USA), and the spatial variation of NO₂ with LULC investigated using random forest, an ensemble data learning technique. The NO2 random forest model, together with BenMAP, is further used to develop a better understanding of the relationship among LULC, ambient NO₂ and respiratory health...
July 10, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28696794/the-effects-of-asthma-medications-on-reactive-oxygen-species-production-in-human-monocytes
#13
Ming-Kai Tsai, Yi-Ching Lin, Ming-Yii Huang, Min-Sheng Lee, Chang-Hung Kuo, Po-Lin Kuo, Ching-Hsiung Lin, Chih-Hsing Hung
OBJECTIVE: Asthma is a chronic inflammatory airway disease induced by many environmental factors. The inhalation of allergens and pollutants promote the reactive oxygen species (ROS) production leading to airway inflammation, hyper-responsiveness and remodeling in allergic asthma. The effects of asthma medications on ROS production are unclear. The present study investigated the anti-ROS effects of current asthma medications including inhaled corticosteroid (ICS; budesonide and fluticasone), leukotriene receptor antagonist (LTRA; montelukast), long acting β2 agonists (LABAs; salmeterol and formoterol) and a new extra-LABA (indacaterol)...
July 11, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28684711/chronic-and-acute-ozone-exposure-in-the-week-prior-to-delivery-is-associated-with-the-risk-of-stillbirth
#14
Pauline Mendola, Sandie Ha, Anna Z Pollack, Yeyi Zhu, Indulaxmi Seeni, Sung Soo Kim, Seth Sherman, Danping Liu
Chronic and acute air pollution has been studied in relation to stillbirth with inconsistent findings. We examined stillbirth risk in a retrospective cohort of 223,375 singleton deliveries from 12 clinical sites across the United States. Average criteria air pollutant exposure was calculated using modified Community Multiscale Air Quality models for the day of delivery and each of the seven days prior, whole pregnancy, and first trimester. Poisson regression models using generalized estimating equations estimated the relative risk (RR) of stillbirth and 95% confidence intervals (CI) in relation to an interquartile range increase in pollutant with adjustment for temperature, clinical, and demographic factors...
July 6, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28673400/the-environment-epigenome-and-asthma
#15
REVIEW
Ivana V Yang, Catherine A Lozupone, David A Schwartz
Asthma prevalence has been on the increase, especially in North America compared with other continents. However, the prevalence of asthma differs worldwide, and in many countries the prevalence is stable or decreasing. This highlights the influence of environmental exposures, such as allergens, air pollution, and the environmental microbiome, on disease etiology and pathogenesis. The epigenome might provide the unifying mechanism that translates the influence of environmental exposures to changes in gene expression, respiratory epithelial function, and immune cell skewing that are hallmarks of asthma...
July 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28673399/environmental-determinants-of-allergy-and-asthma-in-early-life
#16
REVIEW
Allison J Burbank, Amika K Sood, Matthew J Kesic, David B Peden, Michelle L Hernandez
Allergic disease prevalence has increased significantly in recent decades. Primary prevention efforts are being guided by study of the exposome (or collective environmental exposures beginning during the prenatal period) to identify modifiable factors that affect allergic disease risk. In this review we explore the evidence supporting a relationship between key components of the external exposome in the prenatal and early-life periods and their effect on atopy development focused on microbial, allergen, and air pollution exposures...
July 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28666479/desert-dust-outbreaks-and-respiratory-morbidity-in-athens-greece
#17
Stavroula-Myrto Trianti, Evangelia Samoli, Sophia Rodopoulou, Klea Katsouyanni, Spyros A Papiris, Anna Karakatsani
BACKGROUND: Ambient particulate matter (PM) has an adverse effect on respiratory morbidity. Desert dust outbreaks contribute to increased PM levels but the toxicity of desert dust mixed with anthropogenic pollutants needs clarification. METHODS: We identified 132 days with desert dust episodes and 177 matched days by day of the week, season, temperature and humidity between 2001 and 2006 in Athens, Greece. We collected data on regulated pollutants and daily emergency outpatient visits and admissions for respiratory causes...
July 1, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28661182/prenatal-nitrate-exposure-and-childhood-asthma-influence-of-maternal-prenatal-stress-and-fetal-sex
#18
Sonali Bose, Yueh-Hsiu M Chiu, Hsiao-Hsien L Hsu, Qian Di, Maria José Rosa, Alison Lee, Itai Kloog, Ander Wilson, Joel Schwartz, Robert O Wright, Sheldon Cohen, Brent A Coull, Rosalind J Wright
RATIONALE: Impact of ambient pollution upon children's asthma may differ by sex, and exposure dose and timing. Psychosocial stress can also modify pollutant effects. These associations have not been examined for in utero ambient nitrate exposure. OBJECTIVES: We implemented Bayesian distributed lag interaction models (BDLIMs), to identify sensitive prenatal windows for the influence of NO3- on child asthma, accounting for effect modification by sex and stress. METHODS: Analyses included 752 mother-child dyads...
June 29, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28658552/mechanisms-and-treatments-for-severe-steroid-resistant-allergic-airway-disease-and-asthma
#19
REVIEW
Philip M Hansbro, Richard Y Kim, Malcolm R Starkey, Chantal Donovan, Kamal Dua, Jemma R Mayall, Gang Liu, Nicole G Hansbro, Jodie L Simpson, Lisa G Wood, Jeremy A Hirota, Darryl A Knight, Paul S Foster, Jay C Horvat
Severe, steroid-resistant asthma is clinically and economically important since affected individuals do not respond to mainstay corticosteroid treatments for asthma. Patients with this disease experience more frequent exacerbations of asthma, are more likely to be hospitalized, and have a poorer quality of life. Effective therapies are urgently required, however, their development has been hampered by a lack of understanding of the pathological processes that underpin disease. A major obstacle to understanding the processes that drive severe, steroid-resistant asthma is that the several endotypes of the disease have been described that are characterized by different inflammatory and immunological phenotypes...
July 2017: Immunological Reviews
https://www.readbyqxmd.com/read/28658366/fuzzy-model-to-estimate-the-number-of-hospitalizations-for-asthma-and-pneumonia-under-the-effects-of-air-pollution
#20
Luciano Eustáquio Chaves, Luiz Fernando Costa Nascimento, Paloma Maria Silva Rocha Rizol
OBJECTIVE: Predict the number of hospitalizations for asthma and pneumonia associated with exposure to air pollutants in the city of São José dos Campos, São Paulo State. METHODS: This is a computational model using fuzzy logic based on Mamdani's inference method. For the fuzzification of the input variables of particulate matter, ozone, sulfur dioxide and apparent temperature, we considered two relevancy functions for each variable with the linguistic approach: good and bad...
June 22, 2017: Revista de Saúde Pública
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