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Diabetes, Geriatrics, Medicine, Metabolism

Kylie Kavanagh, Ashely T Davis, Kurt A Jenkins, D Mickey Flynn
Increasing heat shock protein 70 (HSP70) in aged and/or insulin-resistant animal models confers benefits to healthspan and lifespan. Heat application to increase core temperature induces HSPs in metabolically important tissues, and preliminary human and animal data suggest that heated hydrotherapy is an effective method to achieve increased HSPs. However, safety concerns exist, particularly in geriatric medicine where organ and cardiovascular disease commonly will preexist. We evaluated young vervet monkeys compared to old, insulin-resistant vervet monkeys (Chlorocebus aethiops sabaeus) in their core temperatures, glucose tolerance, muscle HSP70 level, and selected safety biomarkers after 10 sessions of hot water immersions administered twice weekly...
2016: Cell Stress & Chaperones
Richard L Shriner
The senior patient and/or the geriatrician are confronted with a confusing literature describing how patients interested in combating metabolic syndrome, diabesity (diabetes plus obesity) or simple obesity might best proceed. The present paper gives a brief outline of the basic disease processes that underlie metabolic pro-inflammation, including how one might go about devising the most potent and practical detoxification from such metabolic compromise. The role that dietary restriction plays in pro-inflammatory detoxification (detox), including how a modified fast (selective food abstinence) is incorporated into this process, is developed...
October 2013: Experimental Gerontology
Mehmet Emin Kuyumcu, Yusuf Yesil, Zeynel Abidin Oztürk, Esat Cınar, Cemal Kızılarslanoglu, Meltem Halil, Zekeriya Ulger, Nesibe Karahan Yesil, Mustafa Cankurtaran, Servet Arıoğul
Previous studies showed oxidative stress had an important impact on osteoclastic and osteoblastic functions. Oxidative stress or low levels of antioxidants are supposed to reduce BMD and cause osteoporosis. hcy, gamma glutamyltransferase (GGT), uric acid, albumin and total bilirubin are simple laboratory parameters that are related with oxidative stress. In this study we compare the serum hcy and antioxidant levels in patients with osteoporosis, osteopenia and control subjects. A total of 2190 elderly persons (1348 patients with osteoporosis, 643 patients with osteopenia and 199 control subjects) who were referred to the outpatient clinic of the Department of Internal Medicine, Division of Geriatric Medicine at Hacettepe University Hospital for comprehensive geriatric assessment were included in this cross-sectional study...
November 2012: Archives of Gerontology and Geriatrics
Carlos Rodríguez-Pascual, Sandra Rodriguez-Justo, Eva García-Villar, Maria Narro-Vidal, Marta Torrente-Carballido, Emilio Paredes-Galan
OBJECTIVES: To describe the characteristics, metabolic control and health-related quality of life (HRQL) of type 2 diabetes mellitus (T2DM) geriatric patients. STUDY DESIGN: Cross-sectional descriptive study of consecutive patients attended at a geriatric outpatient clinic in a tertiary hospital over three months. Sociodemographic, geriatric assessment variables, HRQL (using the EuroQol instrument) and comorbidity (Charlson and CIRS-G indexes) were measured. The presence of macrovascular and microvascular complications and cardiovascular risk factors were investigated...
August 2011: Maturitas
Stefano Rizza, Fabrizio Gigli, Angelica Galli, Barbara Micchelini, Davide Lauro, Renato Lauro, Massimo Federici
OBJECTIVES: To study the distribution of adiponectin isoforms in a group of very old patients. DESIGN: Cross-sectional. SETTING: Geriatric ambulatory clinic of the Department of Medicine at Policlinico "Tor Vergata." PARTICIPANTS: One hundred eight elderly adults (mean age 85.0+/-3.2) with or without a history of a previous myocardial infarction as proof of established coronary artery disease (CAD) at least 3 months before entry into the study...
April 2010: Journal of the American Geriatrics Society
Charlie Mantel, Hal E Broxmeyer
PURPOSE OF REVIEW: New discoveries focused on mitochondrial metabolism and gene silencing and their regulation by the sirtuin family of protein deacetylases is stimulating new ideas on how to improve geriatric medicine. Information about sertuins in stem cell biology is scarce. We consider recent information on sirtuin 1, its role in aging and metabolism in several species and tissues, and attempt to anticipate how it might influence stem cell aging. RECENT FINDINGS: Calorie restriction lengthens lifespan, in part, due to mitochondrial metabolism reorganization through sirtuin 1/peroxisome proliferator-activated receptor gamma-coactivator-1alpha-regulated mitochondrial biogenesis...
July 2008: Current Opinion in Hematology
W C Chumlea
OBJECTIVE: The MNA is a successful screening tool in geriatric medicine, but this success is in Europe or countries with Western health care practice settings. The MNA is not directly applicable in many ethnic groups or countries or those with non-Western cultural and dietary habits or health care systems. There is an increased prevalence of type 2 diabetes, the metabolic syndrome and obesity among the elderly; however, the MNA does not include questions or measures related to these or other important health conditions affected by nutritional status...
November 2006: Journal of Nutrition, Health & Aging
F Clostre
EGb 761 is a standardized extract of dried leaves of Ginkgo biloba containing 24% ginkgo-flavonol glycosides, 6% terpene lactones such as ginkgolides A, B, C, J and bilobalide. Its broad spectrum of pharmacological activities allows it to be in adequacy to the numerous pathological requirements--hemodynamic, hemorheological, metabolic--which occur in cerebral, retinal, cochleovestibular, cardiac or peripheral ischemia. Moreover, EGb 761 has direct effects against necrosis and apoptosis of neurons and improves neural plasticity as evidenced in vestibular compensation...
July 1999: Annales Pharmaceutiques Françaises
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