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Candida colonization

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https://www.readbyqxmd.com/read/28531175/weekly-high-dose-liposomal-amphotericin-b-l-amb-in-critically-ill-septic-patients-with-multiple-candida-colonization-the-ambidex-study
#1
Elie Azoulay, Jean-François Timsit, Alexandre Lautrette, Stephane Legriel, Adeline Max, Stephane Ruckly, Benoit Misset, Yves Cohen, Michel Wolff
BACKGROUND: To demonstrate the feasibility and safety of weekly high-dose liposomal amphotericin B (L-AmB) (as a pre-emptive antifungal treatment) for 2 weeks in patients with septic shock and Candida colonization. METHODS: Pilot, multicentre, open-label, prospective study conducted in seven French ICUs. Non-immunocompromised patients, receiving mechanical ventilation were eligible if they presented ICU-acquired severe sepsis requiring newly administered antibacterial agents and Candida colonization in at least two sites...
2017: PloS One
https://www.readbyqxmd.com/read/28499189/synthesis-biological-evaluation-and-molecular-modeling-study-of-new-1-2-4-triazole-or-1-3-4-thiadiazole-methylthio-derivatives-of-quinazolin-4-3h-one-as-dhfr-inhibitors
#2
Yomna I El-Gazzar, Hanan H Georgey, Shahenda M El-Messery, Heba A Ewida, Ghada S Hassan, Marwa M Raafat, Menna A Ewida, Hussein I El-Subbagh
A new series of 2-mercapto-quinazolin-4-one analogues was designed, synthesized and evaluated for their in vitro DHFR inhibition, antitumor and antimicrobial activity. Compound 17 proved to be the most active DHFR inhibitor with IC50 value of 0.01μM, eight fold more active than methotrexate (MTX). Compounds 16 and 24 showed antitumor activity against human Caco2 colon and MCF-7 breast tumor cell lines with IC50 values of 25.4 and 9.5μg/ml, respectively. Compounds 15, 20, 21 and 30 showed considerable activity against the Gram-positive bacteria Staphylococcus aureus while 24 and 30 proved active against Bacillus subtilis with a magnitude of potency comparable to the broad spectrum antibiotic Ciprofloxacin...
May 4, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/28498297/gastrointestinal-colonization-of-candida-albicans-increases-serum-1%C3%A2-3-%C3%AE-d-glucan-without-candidemia-and-worsens-cecal-ligation-and-puncture-sepsis-in-murine-model
#3
Wimonrat Panpetch, Naraporn Somboonna, Dewi Embong Bulan, Jiraphorn Issara-Amphorn, Navaporn Worasilchai, Malcolm Finkelman, Ariya Chindamporn, Tanapat Palaga, Somying Tumwasorn, Asada Leelahavanichkul
The role of intestinal Candida albicans in bacterial sepsis, in the absence of candidemia, was investigated in murine models. Live C. albicans or normal saline solution (NSS) was administered orally once, followed by 5 days of daily oral antibiotic-mixtures (ATB). Cecal ligation and puncture (CLP) was then performed to induce sepsis.Fecal Candida was detected by culture only in models with Candida administration. Oral Candida administration with/without ATB enhanced gut-pathogenic bacteria as determined by microbiome analysis...
May 11, 2017: Shock
https://www.readbyqxmd.com/read/28493119/co2-sensing-in-fungi-at-the-heart-of-metabolic-signaling
#4
REVIEW
Ronny Martin, Susann Pohlers, Fritz A Mühlschlegel, Oliver Kurzai
Adaptation to the changing environmental CO2 levels is essential for all living cells. In particular, microorganisms colonizing and infecting the human body are exposed to highly variable concentrations, ranging from atmospheric 0.04 to 5% and more in blood and specific host niches. Carbonic anhydrases are highly conserved metalloenzymes that enable fixation of CO2 by its conversion into bicarbonate. This process is not only crucial to ensure the supply of adequate carbon amounts for cellular metabolism, but also contributes to several signaling processes in fungi, including morphology and communication...
May 10, 2017: Current Genetics
https://www.readbyqxmd.com/read/28479692/phenotypic-switch-the-enigmatic-white-gray-opaque-transition-system-of-candida-albicans
#5
REVIEW
Sushma Basavaraj Bommanavar, Sachin Gugwad, Neelima Malik
Candida albicans represents the most common commensal and opportunistic fungal pathogen colonizing humans. As a member of the normal microflora, it is present on the skin and the mucous membranes of the upper respiratory tract, gastrointestinal tract and female genital tracts. It is therefore not transmitted. It lies in wait for a change in some aspect of the host physiology that normally suppress growth and invasiveness through an enigmatic phenomenon called Phenotypic Switch System or White-Opaque Transition...
January 2017: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/28479680/an-in-vitro-study-of-isolation-of-candidal-strains-in-oral-squamous-cell-carcinoma-patients-undergoing-radiation-therapy-and-quantitative-analysis-of-the-various-strains-using-chromagar
#6
Mohammad Mohsin Abdul Razak Ainapur, Pushpalatha Mahesh, K Vinod Kumar, A Deepak, Ujjwal Mrinal, P Sharada
BACKGROUND: Patients undergoing radiation therapy for oral squamous cell carcinoma (OSCC) have an increased risk of developing oral candidiasis. Radiation-induced hyposalivation is thought to be a major predisposing factor for it. Radiation therapy for 2-3 weeks leads to increase in the number of candidal species in the oral cavity, eventually leading to oral candidiasis. OBJECTIVE: To evaluate and correlate the prevalence of candidal species in the oral cavity of OSCC patients and to compare with radiation dosage at 3(rd) and 6(th) week following radiotherapy...
January 2017: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/28476133/improving-practice-guidelines-for-the-treatment-of-denture-related-erythematous-stomatitis-a-study-protocol-for-a-randomized-controlled-trial
#7
Raphael F de Souza, Muhammad Faheem Khiyani, Carolina A L Chaves, Jocelyne Feine, Jean Barbeau, Ramón Fuentes, Eduardo Borie, Luciana C Crizostomo, Claudia H Silva-Lovato, Pierre Rompre, Elham Emami
BACKGROUND: Denture-related erythematous stomatitis (DES) is a chronic biofilm-mediated disease, affecting one in every three complete denture wearers. Antifungals are the treatment most commonly prescribed by oral health professionals, based on the belief that colonization by Candida spp. is the main cause of DES. However, high recurrence rates and adverse effects are commonly observed, prompting the need for practice guidelines regarding treatment. Results from our pilot study demonstrate that palatal brushing can reduce the palatal inflammation and potentially associated Candida carriage without any need for antifungal therapy...
May 5, 2017: Trials
https://www.readbyqxmd.com/read/28461316/competitive-fitness-of-fluconazole-resistant-clinical-candida-albicans-strains
#8
Christina Popp, Irene Hampe, Tobias Hertlein, Knut Ohlsen, P David Rogers, Joachim Morschhäuser
The pathogenic yeast Candida albicans can develop resistance to the widely used antifungal agent fluconazole, which inhibits ergosterol biosynthesis. Resistance is often caused by gain-of-function mutations in the transcription factors Mrr1, Tac1, and Upc2, which result in constitutive overexpression of multidrug efflux pumps and ergosterol biosynthesis genes, respectively. However, the deregulated gene expression that is caused by hyperactive forms of these transcription factors also reduces the fitness of the cells in the absence of the drug...
May 1, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28456118/dna-interaction-antimicrobial-anticancer-activities-and-molecular-docking-study-of-some-new-vo-ii-cr-iii-mn-ii-and-ni-ii-mononuclear-chelates-encompassing-quaridentate-imine-ligand
#9
Laila H Abdel-Rahman, Ahmed M Abu-Dief, Moustafa O Aboelez, Azza A Hassan Abdel-Mawgoud
The present study was conducted to synthesis of some new imine Cr(III), VO(II), Mn(II) and Ni(II) complexes derived from the condensation of 2-amino phenol with 2-hydroxynapthaldehyde were synthesized. The prepared HNPN imine ligand was analyzed by its melting point, IR, (1)H NMR and (13)C NMR spectroscopies. The investigated HNPN imine complexes were characterized by elemental analysis, FT IR, UV-vis and thermal analysis (TGA) under nitrogen atmosphere from ambient temperature to 750°C. The experimental results revealed that the investigated complexes contain hydrated water molecules...
April 9, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28448623/development-of-the-cutaneous-microbiome-in-the-preterm-infant-a-prospective-longitudinal-study
#10
Mohan Pammi, Jacqueline L O'Brien, Nadim J Ajami, Matthew C Wong, James Versalovic, Joseph F Petrosino
BACKGROUND: Neonatal sepsis in preterm infants is often due to organisms that colonize the skin including Staphylococcus spp. and Candida spp. Development and maturation of the skin microbiome in the neonatal period, especially in preterm infants, may be critical in preventing colonization with pathogens and subsequent progression to neonatal sepsis. Development of the skin microbiome in preterm infants or its determinants in the first 4 weeks of life has not been evaluated. METHODS: We evaluated the skin microbiome from three body sites, antecubital fossa, forehead and gluteal region, in a prospective cohort of 15 preterm (birth weight < 1500 g and < 32 weeks of gestation) and 15 term neonates...
2017: PloS One
https://www.readbyqxmd.com/read/28434823/influence-of-serum-and-polystyrene-plate-type-on-stability-of-candida-albicans-biofilms
#11
Purity N Kipanga, Walter Luyten
Adhesion is a crucial initial step in microbial biofilm formation. Firm attachment to a target surface subsequently ensures successful colonization and survival despite turbulent conditions. In the laboratory, polystyrene plates are commonly used in biofilm experiments and the 'washing/rinse steps' before staining are critical for assaying biofilm viability. However, these rinse steps risk the removal (partially or entirely) of the formed biofilm, resulting in inconsistent results. The aim of the present study was to optimize conditions for firmer biofilms, less prone to disruption and thus significantly reducing well-to-well variability...
April 21, 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/28429365/a-randomized-clinical-trial-about-presence-of-pathogenic-microflora-and-risk-of-peri-implantitis-comparison-of-two-different-types-of-implant-abutment-connections
#12
F Mencio, F De Angelis, P Papi, D Rosella, G Pompa, S Di Carlo
OBJECTIVE: The aim of this in vivo study was to evaluate two different types of implant-abutment connections: screwed connection and cemented connection, analyzing peri-implant bacteria microflora as well as other clinical parameters. PATIENTS AND METHODS: Twenty implants were selected, inserted in 20 patients, 10 with a screwed implant-abutment connection (Group 1) and 10 with a cemented implant-abutment connection (Group 2). The peri-implant microflora was collected, after at least 360 days from the prosthetic rehabilitation, using paper points inserted in peri-implant sulcus for 30 s...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28421452/susceptibility-of-candida-albicans-from-cystic-fibrosis-patients
#13
Raquel Sabino, Elisabete Carolino, Richard B Moss, Niaz Banaei, Cristina Verissimo, David A Stevens
Candida albicans is a common microbe, colonizer and potential pathogen found in respiratory cultures of cystic fibrosis (CF) patients. Because of possible development of resistance in patient isolates resulting from residence in the abnormal milieu of CF patient airways, or from exposure to antifungals, and considering the possibility of patient-to-patient spread of microbes and reports of elevated resistance to other fungal pathogens, it was important to assay the susceptibility of isolates of Candida and compare that profile to isolates from the community...
April 18, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28420276/the-influence-of-maternal-vaginal-flora-on-the-intestinal-colonization-in-newborns-and-3-month-old-infants
#14
Iwona Gabriel, Anita Olejek, Krystyna Stencel-Gabriel, Miroslaw Wielgoś
The role of maternal vaginal bacteria on the colonization of neonatal gut is still matter of discussion. Our aim was estimate the role of maternal vaginal flora on the development of intestinal flora in neonates and 3- months-old infants. 79 maternal-neonatal pairs were included in the study. Vaginal swabs were taken before the rupture of membranes after admission to the delivery ward. First neonatal stool (meconium) and stool at 3-months-old infants were collected and cultured. All samples were subject to a microbiological analysis for Streptococcus, Staphylococcus, Bifidobacterium, Clostridium (including Cl...
April 18, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28419681/oral-mycobiome-in-community-dwelling-elderly-and-its-relation-to-oral-and-general-health-conditions
#15
Myrna Nurlatifah Zakaria, Michiko Furuta, Toru Takeshita, Yukie Shibata, Rini Sundari, Nobuoki Eshima, Toshiharu Ninomiya, Yoshihisa Yamashita
OBJECTIVE: Oral fungal infection is generally associated with dysbiosis related to antibiotic use, immunodeficiency, or frailty. However, fungal colonization in a typical population without apparent symptoms, and its associated conditions are poorly understood. In this study, oral fungal colonization in community-dwelling and independently living elderly populations was evaluated and factors affecting fungal colonization were analyzed. SUBJECTS AND METHODS: The subjects (410; 181 males and 229 females) were 75-99 years of age; those under prior antibiotic use were excluded...
April 18, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28410367/nitric-oxide-charged-catheters-as-a-potential-strategy-for-prevention-of-hospital-acquired-infections
#16
David Margel, Mark Mizrahi, Gili Regev-Shoshani, Mary Ko, Maya Moshe, Rachel Ozalvo, Liat Shavit-Grievink, Jack Baniel, Daniel Kedar, Ofer Yossepowitch, David Lifshitz, Andrei Nadu, David Greenberg, Yossef Av-Gay
BACKGROUND: Catheter-Associated Hospital-Acquired Infections (HAI's) are caused by biofilm-forming bacteria. Using a novel approach, we generated anti-infective barrier on catheters by charging them with Nitric Oxide (NO), a naturally-produced gas molecule. NO is slowly released from the catheter upon contact with physiological fluids, and prevents bacterial colonization and biofilm formation onto catheter surfaces. AIMS AND METHODS: The aim of the study was to assess the anti-infective properties of NO-charged catheters exposed to low concentration (up to 103 CFU/ml) of microbial cells in-vitro...
2017: PloS One
https://www.readbyqxmd.com/read/28396001/creating-durable-and-esthetic-gingival-anatomy-on-a-polyoxymethylene-overdenture-by-using-a-chairside-procedure
#17
Gary R Login
BACKGROUND AND OVERVIEW: Snap-On Smile (DenMat) appliances are tooth-borne overdentures used for a variety of temporary esthetic applications. However, their benefit can be limited in patients with high smile lines and altered gingival architecture because the teeth look too large. CASE DESCRIPTION: In this report, the author shows the chairside application of a silicone denture reline material used to recreate gingival anatomy on an overdenture fabricated from crystallized acetyl resin, the material used in a Snap-On Smile appliance...
April 7, 2017: Journal of the American Dental Association
https://www.readbyqxmd.com/read/28388469/higher-prevalence-of-colonization-with-gardnerella-vaginalis-and-gram-negative-anaerobes-in-patients-with-recurrent-miscarriage-and-elevated-peripheral-natural-killer-cells
#18
R J Kuon, R Togawa, K Vomstein, M Weber, T Goeggl, T Strowitzki, U R Markert, S Zimmermann, V Daniel, A H Dalpke, B Toth
The role of vaginal infections in recurrent miscarriage (RM) is discussed controversially and screening is not recommended in international guidelines. Peripheral and uterine NK cells (pNK, uNK) play an important role in the establishment of a healthy pregnancy and are targets of immune diagnostics in RM patients. The aim of this study was to analyze the composition of the vaginal microbiota in RM patients and to correlate the findings to clinical characteristics as well as NK cell parameters. In total, n=243 RM patients with ≥3 consecutive miscarriages were recruited between 11/2011 and 03/2016...
March 30, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/28385421/prevalence-of-candida-albicans-candida-dubliniensis-and-candida-africana-in-pregnant-women-suffering-from-vulvovaginal-candidiasis-in-argentina
#19
María Josefina Mucci, María Luján Cuestas, María Fernanda Landanburu, María Teresa Mujica
BACKGROUND: Vulvovaginal candidiasis (VVC) is a vulvovaginitis commonly diagnosed in gynecology care. In recent years, the taxonomy of the most important pathogenic Candida species, such as Candida albicans have undergone significant changes. AIMS: This study examined the prevalence of C. albicans, Candida africana, and Candida dubliniensis in vaginal specimens from 210 pregnant women suffering from vulvovaginitis or having asymptomatic colonization. METHODS: Phenotypic and molecular methods were used for the identification of the species...
April 3, 2017: Revista Iberoamericana de Micología
https://www.readbyqxmd.com/read/28378240/candida-albicans-germ-tube-antibody-evaluation-of-a-new-automatic-assay-for-diagnosing-invasive-candidiasis-in-icu-patients
#20
Manuel Parra-Sánchez, Ismail Zakariya-Yousef Breval, Carmen Castro Méndez, Silvia García-Rey, Ana Loza Vazquez, Alejandro Úbeda Iglesias, Desiree Macías Guerrero, Ana Romero Mejías, Cristobal León Gil, Estrella Martín-Mazuelos
Testing for Candida albicans germ-tube antibody IFA IgG assay (CAGTA) is used to detect invasive candidiasis infection. However, most suitable assays lack automation and rapid single-sample testing. The CAGTA assay was adapted in an automatic monotest system (invasive candidiasis [CAGTA] VirClia(®) IgG monotest (VirClia(®)), a chemiluminescence assay with ready-to-use reagents that provides a rapid objective result. CAGTA assay was compared with the monotest automatic VirClia(®) assay in order to establish the diagnostic reliability, accuracy, and usefulness of this method...
April 4, 2017: Mycopathologia
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