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Double Sequential

Matthieu Glorion, Olaf Mercier, Delphine Mitilian, Alexandra De Lemos, Lilia Lamrani, Séverine Feuillet, Pauline Pradere, Jérôme Lepavec, Daniel Lehouerou, François Stephan, Laurent Savale, Dominique Fabre, Sacha Mussot, Elie Fadel
OBJECTIVES: Extracorporeal membrane oxygenation (ECMO) has become the standard of cardiopulmonary support during a sequential double lung transplant for pulmonary hypertension. Whether central or peripheral cannulation is the best strategy for these patients remains unknown. Our goal was to determine which is the best strategy by comparing 2 populations of patients. METHODS: We performed a single-centre retrospective study based on an institutional prospective lung transplant database...
March 8, 2018: European Journal of Cardio-thoracic Surgery
Dalton T Snyder, Lucas J Szalwinski, Robert L Schrader, Valentina Pirro, Ryan Hilger, R Graham Cooks
Methodology for performing precursor and neutral loss scans in an RF scanning linear quadrupole ion trap is described and compared to the unconventional ac frequency scan technique. In the RF scanning variant, precursor ions are mass selectively excited by a fixed frequency resonance excitation signal at low Mathieu q while the RF amplitude is ramped linearly to pass ions through the point of excitation such that the excited ion's m/z varies linearly with time. Ironically, a nonlinear ac frequency scan is still required for ejection of the product ions since their frequencies vary nonlinearly with the linearly varying RF amplitude...
March 9, 2018: Journal of the American Society for Mass Spectrometry
Nathaniel J L K Davis, Jesse R Allardice, James Xiao, Anthony J Petty Ii, Neil C Greenham, John E Anthony, Akshay Rao
Singlet exciton fission allows for the generation of two triplet excitons for each photon absorbed within an organic semiconductor. Efficient harvesting of these triplets could allow for the Shockley-Queisser limit on the power conversion efficiency of single-junction photovoltaics to be broken. Here, we show that singlet fission molecules bound directly to PbS quantum dots as ligands can undergo singlet fission with near unity efficiency and can transfer triplets sequentially into the PbS with near unity efficiency...
March 5, 2018: Journal of Physical Chemistry Letters
Kun Cao, Nan Li, Hongcui Wang, Xin Cao, Jiaojiao He, Bing Zhang, Qing-Yu He, Gong Zhang, Xuesong Sun
Zinc is an essential metal in bacteria. One important bacterial zinc transporter is AdcA, and most bacteria possess AdcA homologs that are single-domain small proteins owing to better efficiency of protein biogenesis. However, a double-domain AdcA with two zinc-binding sites is significantly overrepresented in Streptococcus species, many of which are major human pathogens. Using molecular simulation and experimental validations of AdcA from Streptococcus pyogenes, we found here that the two AdcA domains sequentially stabilize the structure upon zinc binding, indicating an organization required for both increased zinc affinity and transfer speed...
February 28, 2018: Journal of Biological Chemistry
Peter C Taylor, Michael H Schiff, Qingmin Wang, Yusang Jiang, Yanli Zhuang, Regina Kurrasch, Shruti Daga, Ravi Rao, Paul P Tak, Benjamin Hsu
OBJECTIVE: This randomised, double-blind, parallel-group, phase 3 study compared monotherapy with sirukumab, an anti-interleukin-6 cytokine monoclonal antibody, with adalimumab monotherapy in patients with rheumatoid arthritis (RA). METHODS: Biologic-naïve patients with active RA who were inadequate responders or were intolerant to, or inappropriate for, methotrexate were randomised to subcutaneous sirukumab 100 mg every 2 weeks (n=187), sirukumab 50 mg every 4 weeks (n=186) or adalimumab 40 mg every 2 weeks (n=186)...
February 26, 2018: Annals of the Rheumatic Diseases
S Jeremić, A Amić, M Stanojević-Pirković, Z Marković
Disruption of homeostasis can increase the amount of free radicals formed during metabolic processes. This phenomenon known as oxidative stress can have numerous negative outcomes. The role of dietary antioxidants is to help the prevention of oxidative stress. We investigated free radical scavenging capacity of six structurally similar anthraquinones (alizarin, purpurin, chrysophanol, emodin, aloe-emodin and 1,3,8-trihydroxyanthraquinone) for inactivating a set of ten hydroxy and peroxy free radicals. The antioxidant capacity of anthraquinones was estimated by considering Gibbs free energy of three studied reaction mechanisms: hydrogen atom transfer (HAT), single-electron transfer followed by proton transfer (SET-PT) and sequential proton loss electron transfer (SPLET)...
February 26, 2018: Organic & Biomolecular Chemistry
Anne Elisabeth E Berns, Herbert Philipp, Hans Lewandowski, Jeong-Heui Choi, Marc Lamshöft, Hans-Dieter Narres
The extensive use of sulfonamides (SNs) in animal husbandry has led to an unintentional widespread occurrence in several environmental compartments. The implementation of regulations and management recommendations to reduce the potential risk of development of antibiotic resistances necessitates detailed knowledge on their fate in soil. We present results from two independent incubation studies of15 N-labeled sulfadiazines (SDZ) which focused on identifying binding types in bound residues. In the first study15 N-amino labeled SDZ was incubated with two previously isolated humic acids in the presence and absence of Trametes versicolor laccase, while in the second study15 N-double-labeled SDZ was incubated with a typical agricultural Luvisol and isolated the humic acid fraction after sequential extraction of the soil...
February 21, 2018: Environmental Science & Technology
Jiangsong Jiang, Nishant Mohan, Yukinori Endo, Yi Shen, Wen Jin Wu
Despite heightened risk of cardiotoxicity associated with combination therapy of anthracyclines and trastuzumab in HER2-positive breast cancer patients, little research effort has been invested in exploring the molecular mechanisms of cardiotoxicity induced by this combination therapy. In this study, we demonstrate that trastuzumab downregulates both gene and protein expressions of type IIB DNA topoisomerase/DNA topoisomerase IIB (TOP2B), a major intracellular target mediating doxorubicin-induced cardiotoxicity, in human primary cardiomyocytes...
January 19, 2018: Oncotarget
Pingyun Yuan, Xinyu Qiu, Ronghua Jin, Yongkang Bai, Shiyu Liu, Xin Chen
Herein, we reveal a double emulsion method combining the sol-gel method to prepare poly(lactic-co-glycolic acid) microspheres with different porous structures for sequential release of two types of biomolecules. By controlling the ripening time of the emulsion, multiple interconnected chambers could be easily chosen to be either embedded in microspheres or opened to the surface. These two types of microspheres exhibited different kinetics for the release of both small molecules and proteins, where the release from microspheres with open pores (5 day over 90%) was much faster than the release from microspheres with embedded pores (25 day over 90%)...
February 20, 2018: Biomaterials Science
Ye Zhang, Isabel Huth, Damien Charles Weber, Antony John Lomax
BACKGROUND AND PURPOSE: Different scanned proton therapy systems provide different scanning scenarios, directly changing the temporal interference between sequential beam delivery and tumour motion. We aim here to quantify the interplay effects and compare motion mitigation performance among different PBS scanning systems. MATERIALS AND METHODS: Using 6 4DCT(MRI) datasets of liver tumours with irregular motions greater than 10 mm, 4D treatments with single- and double-field plans, and assuming various doses and motion mitigation approaches, were simulated for 8 PBS scenarios including spot or raster scanning, layered or volumetric rescanning, gating, constant or varying beam current and cyclotron or synchrotron beam sources...
February 16, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Chao-Wei Hsu, Wei-Wen Su, Chuan-Mo Lee, Cheng-Yuan Peng, Wan-Long Chuang, Jia-Horng Kao, Heng-Cheng Chu, Yi-Hsiang Huang, Rong-Nan Chien, Yun-Fan Liaw
BACKGROUND: Efficacy of sequential therapy with nucleos(t)ide analogues and interferons versus monotherapy in patients with hepatitis B e antigen (HBeAg)-positive chronic hepatitis B (CHB) remains unexplored. We aimed to assess efficacy and safety of sequential therapy with adefovir (ADV) or entecavir (ETV) followed by peginterferon (PEG-IFN) alfa-2a in Taiwanese patients with HBeAg-positive. METHODS: This randomized, placebo-controlled, double-blind trial was conducted at nine sites in Taiwan from April 2010 to October 2013...
February 15, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
Sahar Sultan, Aji P Mathew
3-Dimensional (3D) printing provides a unique methodology for the customization of biomedical scaffolds with respect to size, shape, pore structure and pore orientation useful for tissue repair and regeneration. 3D printing was used to fabricate fully bio-based porous scaffolds of a double crosslinked interpenetrating polymer network (IPN) from a hydrogel ink of sodium alginate and gelatin (SA/G) reinforced with cellulose nanocrystals (CNCs). CNCs provided favorable rheological properties required for 3D printing...
February 16, 2018: Nanoscale
Elke Gasthuys, An Vermeulen, Siska Croubels, Joske Millecam, Stijn Schauvliege, Thomas van Bergen, Pauline De Bruyne, Johan Vande Walle, Mathias Devreese
Desmopressin is used to treat primary nocturnal enuresis in children. Over the years, various formulations of desmopressin were commercialized of which the sublingual melt tablet is preferred in the pediatric population, despite the lack of full PK studies in this population. A full PK study was performed in growing conventional piglets to evaluate if this juvenile animal model can provide supplementary information to complement the information gap in the pediatric population. A desmopressin sublingual melt tablet (120 μg) was administered to 32 male piglets aged 8 days, 4 weeks, 7 weeks, and 6 months (each group n = 8)...
2018: Frontiers in Pharmacology
Wilson I Omesiete, James A Walker, Jack C Yu
INTRODUCTION: Current protocols for venous thromboembolism (VTE) prophylaxis after craniofacial surgery (CFS) vary widely with substantial disagreements in both indications and managements. An evidence-based approach to this issue requires the following: the incidence of postoperative VTE, comorbidities associated with coagulopathy, risk reduction after VTE prophylaxis, and complications attributable to prophylaxis. This study addresses the first two. DESIGN: Retrospective cross-sectional study...
February 13, 2018: Annals of Plastic Surgery
Jordan Abdi, Ahmed Al-Hindawi, Tiffany Ng, Marcela P Vizcaychipi
OBJECTIVE: With an elderly population that is set to more than double by 2050 worldwide, there will be an increased demand for elderly care. This poses several impediments in the delivery of high-quality health and social care. Socially assistive robot (SAR) technology could assume new roles in health and social care to meet this higher demand. This review qualitatively examines the literature on the use of SAR in elderly care and aims to establish the roles this technology may play in the future...
February 12, 2018: BMJ Open
Yongping Xin, Tingting Guo, Yingli Mu, Jian Kong
BACKGROUND: Lactobacillus casei is widely used in the dairy and pharmaceutical industries and a promising candidate for use as cell factories. Recently, genome sequencing and functional genomics provide the possibility for reducing L. casei genome. However, it was still limited by the inefficient and laborious genome deletion methods. RESULTS: Here, we proposed a genome minimization strategy based on LCABL_13040-50-60 recombineering and Cre-lox site-specific recombination system in L...
February 12, 2018: Microbial Cell Factories
Putu Virgina Partha Devanthi, Hani El Kadri, Allen Bowden, Fotios Spyropoulos, Konstantinos Gkatzionis
Antagonism in mixed culture fermentation can result in undesirable metabolic activity and negatively affect the fermentation process. Water-oil-water (W1/O/W2) double emulsions (DE) could be utilized in fermentation for segregating multiple species and controlling their release and activity. Zygosaccharomyces rouxii and Tetragenococcus halophilus, two predominant microbial species in soy sauce fermentation, were incorporated in the internal W1 and external W2 phase of a W1/O/W2, respectively. The suitability of DE for controlling T...
March 2018: Food Research International
Xue Li, Yingchun Wang, Jia Wang, Tianwei Zhang, Li Zheng, Zhenfan Yang, Ligang Xing, Jinming Yu
The prognosis of patients with brain metastasis (BM) is poor. In this study, we demonstrated that AZD3759, an EGFR tyrosine kinase inhibitors (TKIs) with excellent blood-brain barrier (BBB) penetration, combined with radiation enhanced the antitumor efficacy in BM model from EGFR mutant (EGFRm) NSCLC. Besides, the antitumor activity displayed no difference between radiation concurrently with AZD3759 and radiation sequentially with AZD3759. Mechanistically, we found that two factors determined the enhanced efficacy: cells with EGFRm which were sensitive to AZD3759, and a relative high concentration of AZD3759...
February 12, 2018: International Journal of Cancer. Journal International du Cancer
Dawit G Seifu, Sébastien Meghezi, Larry Unsworth, Kibret Mequanint, Diego Mantovani
Since collagen is one of the major extracellular matrix components in vascular tissues, its use for vascular tissue engineering has several advantages. However, collagen extraction and processing for tissue engineering application alters its structure. As a result, collagen-based vascular constructs show poor mechanical properties compared to native tissues. In this work, multi-layer (single, double, and triple) vascular tissue constructs were engineered from porcine smooth muscle cells (PSMCs) entrapped in collagen gel by concentrically and sequentially layering after compaction of the previous layer(s)...
February 2, 2018: Journal of the Mechanical Behavior of Biomedical Materials
Li Hongxin, Guo Wenbin, Hai-Zhou Zhang, Fei Liang, Gui-Dao Yuan, Zeeshan Farhaj, Jun Zhang
BACKGROUND: The current approaches of transcatheter closure of mitral paravalvular leak (MPVL) have different drawbacks. The challenges come from transseptal puncture, accessing the MPVL site, and the absence of dedicated delivery systems. This study introduces a novel peratrial approach for device closure of different locations of MPVLs using a probe-assisted delivery system under three-dimensional transesophageal echocardiography. METHODS: A 4.0 cm minithoracotomy incision was made in the fourth right interspaces...
February 2, 2018: Annals of Thoracic Surgery
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