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https://www.readbyqxmd.com/read/28446274/-efficacy-of-idarubicin-based-stratified-therapy-for-acute-promyelocytic-leukemia
#1
Wei Guan, Wen-Jun Li, Lan Yang, Yu Jing, Li Yu
OBJECTIVE: To investigate the remission rate of all-transretinoic acid (ATRA) combined with arsenics acid(ATO) on acute promyelocytic leukemia, and the efficacy and safety of sequential consolidation therapy with idarubicin, all-trans retinoic acid and arsenic trioxide/compound Huangdai tablet. METHODS: Between January 2011 and January 2016 years 22 patients with newly diagnosed acute promyelocytic leukemia who received ATRA combined with ATO till complete remission in our hospital were retrospectively analyzed...
April 2017: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/28445459/the-effect-of-illumination-on-the-formation-of-metal-halide-perovskite-films
#2
Amita Ummadisingu, Ludmilla Steier, Ji-Youn Seo, Taisuke Matsui, Antonio Abate, Wolfgang Tress, Michael Grätzel
Optimizing the morphology of metal halide perovskite films is an important way to improve the performance of solar cells when these materials are used as light harvesters, because film homogeneity is correlated with photovoltaic performance. Many device architectures and processing techniques have been explored with the aim of achieving high-performance devices, including single-step deposition, sequential deposition and anti-solvent methods. Earlier studies have looked at the influence of reaction conditions on film quality, such as the concentration of the reactants and the reaction temperature...
April 26, 2017: Nature
https://www.readbyqxmd.com/read/28442953/role-of-flupirtine-in-reducing-preoperative-anxiety-of-patients-undergoing-craniotomy-procedure
#3
Ghanshyam Yadav, Gaurav Jain, Malkhan Singh
BACKGROUND: Kv7 neuronal channels are recognized as a potential drug target for anxiolytic effects. We hypothesize that flupirtine as a potassium channel opener would effectively reduce the preoperative anxiety of patients undergoing craniotomy procedure. METHODS: In prospective-double-blinded fashion, 124 counseled patients were randomized to receive 5 sequential doses of capsule flupirtine 100 mg (F Group) or physically similar starch capsules (C Group), at 12 h intervals during preoperative hospitalization...
April 2017: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/28437331/do-the-position-and-orientation-of-the-crosslink-influence-the-stiffness-of-spinal-instrumentation
#4
Zhuo Wang, Toshihiko Sakakibara, Takamasa Yoshikawa, Tadashi Inaba, Yuichi Kasai
STUDY DESIGN: Biomechanical study of double-level pedicle screw constructs with or without crosslinks (CL) in an unstable model. OBJECTIVES: The purpose of this study is to investigate the optimal position and orientation of the CL. SUMMARY OF BACKGROUND DATA: Several reports have described biomechanical research on such CL, but no definite consensus has been reached regarding the effects. Very few studies have examined the position and orientation of the CL...
May 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28429946/ag-catalyzed-intramolecular-sequential-vicinal-diamination-of-alkynes-with-isocyanates-synthesis-of-fused-indole-cyclic-urea-derivatives
#5
Manda Rajesh, Surendra Puri, Ruchir Kant, Maddi Sridhar Reddy
A formal intramolecular vicinal 1,2-diamination of alkynes is achieved for the synthesis of indole-cyclic urea fused derivatives through double cyclization process from readily available aminophenyl propargyl alcohols. This sequential triple C-N bond construction event was possible using isocyanate as urea precursor and Ag(I) catalyst as alkyne activating agent. Control experiments reveal that the cyclization followed by 1,3-allylic amino dehydroxylation is preceded by urea formation.
April 21, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28425942/seasonal-dynamics-of-haptophytes-and-dsdna-algal-viruses-suggest-complex-virus-host-relationship
#6
Torill Vik Johannessen, Aud Larsen, Gunnar Bratbak, António Pagarete, Bente Edvardsen, Elianne D Egge, Ruth-Anne Sandaa
Viruses influence the ecology and diversity of phytoplankton in the ocean. Most studies of phytoplankton host-virus interactions have focused on bloom-forming species like Emiliania huxleyi or Phaeocystis spp. The role of viruses infecting phytoplankton that do not form conspicuous blooms have received less attention. Here we explore the dynamics of phytoplankton and algal viruses over several sequential seasons, with a focus on the ubiquitous and diverse phytoplankton division Haptophyta, and their double-stranded DNA viruses, potentially with the capacity to infect the haptophytes...
April 20, 2017: Viruses
https://www.readbyqxmd.com/read/28416574/a-glutamate-substituted-mutant-mimics-the-phosphorylated-and-active-form-of-guanylyl-cyclase-a
#7
Neil M Otto, William G McDowell, Deborah M Dickey, Lincoln R Potter
Multisite phosphorylation is required for activation of guanylyl cyclase (GC)-A, also known as NPR-A or NPR1, by cardiac natriuretic peptides (NPs). Seven chemically identified sites (Ser-487, Ser-497, Thr-500, Ser-502, Ser-506, Ser-510, Thr-513) and one functionally identified putative site (Ser-473) were reported. Single alanine substitutions for Ser-497, Thr-500, Ser-502, Ser-506 and Ser-510 reduced maximal velocity (Vmax), while glutamate substitutions had no effect or increased Vmax. Ala but not Glu substitution for Ser-497 increased the Michaelis constant (Km) ~400%...
April 17, 2017: Molecular Pharmacology
https://www.readbyqxmd.com/read/28408193/imipramine-versus-placebo-for-multiple-functional-somatic-syndromes-stress-3-a-double-blind-randomised-study
#8
Johanne L Agger, Andreas Schröder, Lise K Gormsen, Jens S Jensen, Troels S Jensen, Per K Fink
BACKGROUND: Functional somatic syndromes, including chronic fatigue syndrome or irritable bowel syndrome, often co-exist. Treatment guidelines supported by high quality evidence exist for most functional somatic syndromes, but are lacking for multiple comorbid functional somatic syndromes. We aimed to assess the effect of the tricyclic antidepressant, imipramine, in patients with multiple functional somatic syndromes defined by the criteria for multiorgan bodily distress syndrome, a unifying diagnosis that encompasses most functional somatic syndromes and somatoform disorders...
April 10, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28407311/biological-variability-in-serum-cortisol-concentration-post-adrenocorticotropic-hormone-stimulation-in-healthy-dogs
#9
A Gal, K Weidgraaf, J P Bowden, N Lopez-Villalobos, N J Cave, J P Chambers, F Castillo-Alcala
BACKGROUND: The ACTH stimulation has low sensitivity for the diagnosis of hypercortisolism possibly as a result of biological and analytical variability. HYPOTHESIS/OBJECTIVES: To report the components of biological and analytical variability in serum cortisol concentration post-ACTH stimulation ([cortisol]) in healthy dogs. ANIMALS: Fourteen healthy harrier hound dogs. METHODS: The data were extracted from a separate, prospective, randomized, double-blinded, controlled discovery study in which dogs treated with vehicle control and 4 different doses of cortisone acetate (CA) for 7 days had an ACTH stimulation test performed to confirm the dose-dependent effect of CA...
April 13, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28406306/chiral-diphosphine-palladium-catalyzed-sequential-asymmetric-double-friedel-crafts-alkylation-and-n-hemiketalization-for-spiro-polycyclic-indole-derivatives
#10
Nai-Kai Li, Jun-Qi Zhang, Bing-Bing Sun, Hai-Yan Li, Xing-Wang Wang
An efficient cascade asymmetric Friedel-Crafts alkylation/N-hemiketalization/Friedel-Crafts alkylation reaction of 3-alkylindoles with oxindolyl β,γ-unsaturated α-ketoesters has been developed in the presence of a chiral diphosphine-palladium(II) catalyst. A series of enantiomerically enriched spiro-polycyclic indole derivatives have been constructed in high yields with excellent enantioselectivities and diastereoselectivities.
April 13, 2017: Organic Letters
https://www.readbyqxmd.com/read/28404092/tenofovir-alafenamide-versus-tenofovir-disoproxil-fumarate-for-the-treatment-of-patients-with-hbeag-negative-chronic-hepatitis-b-virus-infection-a-randomised-double-blind-phase-3-non-inferiority-trial
#11
Maria Buti, Edward Gane, Wai Kay Seto, Henry L Y Chan, Wan-Long Chuang, Tatjana Stepanova, Aric-Josun Hui, Young-Suk Lim, Rajiv Mehta, Harry L A Janssen, Subrat K Acharya, John F Flaherty, Benedetta Massetto, Andrea L Cathcart, Kyungpil Kim, Anuj Gaggar, G Mani Subramanian, John G McHutchison, Calvin Q Pan, Maurizia Brunetto, Namiki Izumi, Patrick Marcellin
BACKGROUND: The novel prodrug tenofovir alafenamide delivers the nucleotide reverse transcriptase inhibitor tenofovir to target cells more efficiently at a lower dose than tenofovir disoproxil fumarate, thereby reducing systemic exposure. We compared the efficacy and safety of the two drugs in patients with HBeAg-negative chronic hepatitis B virus (HBV) infection in a non-inferiority study. METHODS: In this ongoing randomised, double-blind, phase 3, non-inferiority study in 105 centres in 17 countries, patients with HBeAg-negative chronic HBV were randomly assigned (2:1) by a computer-generated allocation sequence (block size six), stratified by plasma HBV DNA concentration and previous treatment status, to receive once-daily oral doses of tenofovir alafenamide 25 mg or tenofovir disoproxil fumarate 300 mg, each with matching placebo...
November 2016: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28401523/injection-of-pharmaceuticals-designed-for-oral-use-harms-experienced-and-effective-harm-reduction-through-filtration
#12
Stuart McLean, Rahul Patel, Raimondo Bruno
Several pharmaceutical products are liable to 'abuse' or use outside their prescription, which frequently involves their injection. Examples are slow-release forms of morphine and oxycodone, and sublingual buprenorphine. During injection preparation, the drug is extracted into water, after crushing and heating the tablet if considered necessary. Since these products are designed for oral administration, they can contain excipients (ingredients other than the drug) which are poorly soluble, resulting in suspension of particles in the injection solution...
April 2, 2017: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/28400170/enhanced-simultaneous-saccharification-and-fermentation-of-pretreated-beech-wood-by-in-situ-treatment-with-the-white-rot-fungus-irpex-lacteus-in-a-membrane-aerated-biofilm-reactor
#13
Simone Brethauer, Shahab Robert Lawrence, Studer Michael Hans-Peter
The aim of the present study was to investigate the combination of steam pretreatment and biological treatment with lignin degrading fungal strains in order to enable efficient bioprocessing of beech wood to ethanol. In a sequential process of steam and fungal pretreatment followed by enzymatic hydrolysis, Irpex lacteus almost doubled the glucose yield for mildly pretreated beech wood, but could not improve yields for more severely pretreated substrates. However, when simultaneous saccharification and fermentation is combined with in situ I...
March 18, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28393947/production-of-doubly-charged-highly-reactive-species-from-the-long-chain-amino-acid-gaba-initiated-by-ar-9-ionization
#14
Dariusz Grzegorz Piekarski, Rudy Delaunay, Arkadiusz Mika, Sylvain Maclot, Lamri Adoui, Fernando Martín, Manuel Alcamí, Bernd A Huber, Patrick Rousseau, Sergio Díaz-Tendero, Alicja Domaracka
We present a combined experimental and theoretical study of the fragmentation of multiply-charged γ-aminobutyric acid molecules (GABA(z+), z = 2, 3) in the gas phase. The combination of ab initio molecular dynamics simulations with multiple-coincidence mass spectrometry techniques allows us to observe and identify doubly-charged fragments in coincidence with another charged moiety. The present results indicate that double and triple electron capture lead to the formation of doubly-charged reactive nitrogen and oxygen species (RNS and ROS) with different probabilities due to the different charge localisation and fragmentation behaviour of GABA(2+) and GABA(3+)...
April 10, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28388045/intense-field-multiple-detachment-of-f2%C3%A2-competition-with-photodissociation
#15
Abhishek Shahi, Yishai Albeck, Daniel Strasser
The competition of intense-field multiple-detachment with efficient photodissociation of F2¯ is studied as a function of laser peak intensity. The main product channels are disentangled and characterized by 3D coincidence fragment imaging. The presented kinetic energy release spectra, angular distributions, as well as two-color pump-probe measurements allow identification of competing sequential and nonsequential mechanisms. Dissociative detachment, producing two neutral atoms (F + F), is found to be dominated by a sequential mechanism of photodissociation (F¯ + F), followed by detachment of the atomic anion fragment...
April 14, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28384980/anti-bacterial-efficacy-of-terminalia-chebula-terminalia-bellirica-embilica-officinalis-and-triphala-on-salivary-streptococcus-mutans-count-a-linear-randomized-cross-over-trial
#16
Smariti Saxena, Nagesh Lakshminarayan, Shanmukha Gudli, Manish Kumar
INTRODUCTION: From the oral health perspective, it is well established that microorganisms have an important role in caries aetiology. From the dawn of civilization, herbal plants have served an array of roles. Triphala a tradtional herbal Ayurvedic formula consists of three native fruits of india including Terminalia Chebula (T. chebula), Terminalia Bellirica (T. bellirica) and Embilica Officinalis (E. officinalis). As per Ayurvedic Formulary of India (AFI) Triphala is prepared by combining a 1:1:1 mixture of ground dry fruits called myrobalans...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28381256/double-or-nothing-red-flag-symptoms-of-critical-carotid-stenosis-a-case-report
#17
José Carlos Morán-Sánchez, Irene Gómez-Estévez, Yasmina El Berdei, José C Gómez-Sánchez, María E Ramos-Araque
BACKGROUND: Detailed knowledge of every possible manifestation of Internal Carotid Artery (ICA) disease is important. For improving detection and a timely adoption of secondary prevention procedures or treatments. Transient oculomotor nerve palsies have been described associated with stenosis or occlusion of the ICA. CASE PRESENTATION: We described a patient that develop a sequential combination of transient monocular loss of vision followed by binocular diplopia secondary to an unstable atherosclerotic preocclusive stenosis of an internal carotid artery previously treated with radiotherapy...
April 5, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28380956/dissection-of-electron-correlation-in-strong-field-sequential-double-ionization-using-a-classical-model
#18
Yueming Zhou, Min Li, Yang Li, Aihong Tong, Qianguang Li, Peixiang Lu
Recent experiments on strong-field sequential double ionization (SDI) have reported several observations which are regarded as evidence of electron correlation, querying the validity of the standard independent electron approximation for SDI. Here we theoretically study SDI with a classical ensemble model. The experimental results are well reproduced with this model. Back tracing of the ionization process shows that these results are ascribed to the subcycle ionization dynamics of the two electrons, not the evidences of the electron correlation in SDI...
April 3, 2017: Optics Express
https://www.readbyqxmd.com/read/28380313/cholesterol-cholesterol-lowering-medication-use-and-breast-cancer-outcome-in-the-big-1-98-study
#19
Signe Borgquist, Anita Giobbie-Hurder, Thomas P Ahern, Judy E Garber, Marco Colleoni, István Láng, Marc Debled, Bent Ejlertsen, Roger von Moos, Ian Smith, Alan S Coates, Aron Goldhirsch, Manuela Rabaglio, Karen N Price, Richard D Gelber, Meredith M Regan, Beat Thürlimann
Purpose Cholesterol-lowering medication (CLM) has been reported to have a role in preventing breast cancer recurrence. CLM may attenuate signaling through the estrogen receptor by reducing levels of the estrogenic cholesterol metabolite 27-hydroxycholesterol. The impact of endocrine treatment on cholesterol levels and hypercholesterolemia per se may counteract the intended effect of aromatase inhibitors. Patients and Methods The Breast International Group (BIG) conducted a randomized, phase III, double-blind trial, BIG 1-98, which enrolled 8,010 postmenopausal women with early-stage, hormone receptor-positive invasive breast cancer from 1998 to 2003...
April 10, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28372209/candida-antarctica-lipase-a-effectively-concentrates-dha-from-fish-and-thraustochytrid-oils
#20
Taiwo O Akanbi, Colin J Barrow
The fatty acid selectivity of Candida antarctica lipase A (CAL-A) was applied to produce DHA concentrate by controlling the rate and extent of hydrolysis. Calcium was utilized to achieve a higher degree of hydrolysis. CAL-A was not regioselective but rather fatty acid selective, showing sequential selectivity for saturated, monounsaturated and polyunsaturated fatty acids in the order of increasing double bonds. Based on its strong initial preference for saturates, CAL-A was used to concentrate 82% docosahexaenoic acid (DHA) and 11% omega-6 docosapentaenoic acid (DPA-n6) after partial hydrolysis of algal oil...
August 15, 2017: Food Chemistry
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