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https://www.readbyqxmd.com/read/28096005/effect-of-recorded-male-lullaby-on-physiologic-response-of-neonates-in-nicu
#1
Leila Taheri, Marzieh Kargar Jahromi, Mohammad Abbasi, Mohsen Hojat
PURPOSE: Most infants in the NICU are exposed to sensory overloads and deprivations as part of their care. This study conducted to assess the effect of lullaby on physiologic response of neonates admitted to NICU. METHOD: This is a randomized double-blind intervention trial which was performed on 52 neonates in Jahrom (Iran) 2013-2014. The samples were randomly assigned into lullaby group and a control group (sampling was sequential and randomization was by lottery)...
February 2017: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/28095795/intrathecal-magnesium-sulfate-does-not-reduce-the-ed50-of-intrathecal-hyperbaric-bupivacaine-for-cesarean-delivery-in-healthy-parturients-a-prospective-double-blinded-randomized-dose-response-trial-using-the-sequential-allocation-method
#2
Fei Xiao, Wenping Xu, Ying Feng, Feng Fu, Xiaomin Zhang, Yinfa Zhang, Lizhong Wang, Xinzhong Chen
BACKGROUND: Addition of intrathecal magnesium sulfate to local anesthetics has been reported to potentiate spinal anesthesia and prolong analgesia in parturients. The current study was to determine whether intrathecal magnesium sulfate would reduce the dose of hyperbaric bupivacaine in spinal anesthesia with bupivacaine and sufentanil for cesarean delivery. METHODS: Sixty healthy parturients undergoing scheduled cesarean delivery were randomly assigned to receive spinal anesthesia with 0...
January 17, 2017: BMC Anesthesiology
https://www.readbyqxmd.com/read/28074620/double-immunostaining-for-maspin-and-p53-on-cell-blocks-increases-the-diagnostic-value-of-biliary-brushing-cytology
#3
Maki Kanzawa, Tsuyoshi Sanuki, Manabu Onodera, Kohei Fujikura, Tomoo Itoh, Yoh Zen
Our objective is to elucidate the usefulness of maspin/p53 double immunostaining on biliary brushing cytology specimens. We first examined the expression of maspin in the biliary epithelium with variable degrees of dysplasia using surgically resected specimens (n = 56). Maspin appeared to be overexpressed in a stepwise manner from benign to malignant cholangiocytes: the reactive epithelium (20%), biliary intraepithelial neoplasia (~50%), and invasive cholangiocarcinomas (>90%). Next, an automated sequential double immunostaining protocol for maspin and p53 was applied to paraffin-embedded cell blocks of the biliary brushing cytology specimens obtained from 58 consecutive patients...
January 10, 2017: Pathology International
https://www.readbyqxmd.com/read/28067925/mesoporous-tio2-n-doped-carbon-composite-nanospheres-synthesized-by-the-direct-carbonization-of-surfactants-after-sol-gel-process-for-superior-lithium-storage
#4
Hongwei Zhu, Yunke Jing, Manas Pal, Yupu Liu, Yang Liu, Jinxiu Wang, Fan Zhang, Dongyuan Zhao
Here, we report mesoporous TiO2@N-doped carbon composite nanospheres synthesized via a double-surfactant-assisted assembly sol-gel process followed by sequential carbonization of surfactants under a N2 atmosphere. The resulting TiO2@N-doped C composite nanospheres are composed of uniformly distributed TiO2 nanocrystals with a diameter of ∼8 nm coated by a N-doped carbon layer that was formed by surfactants. Moreover, a large number of connected mesopores were observed in the nanospheres after high-temperature carbonization treatment...
January 9, 2017: Nanoscale
https://www.readbyqxmd.com/read/28065188/flavanone-rich-citrus-beverages-counteract-the-transient-decline-in-postprandial-endothelial-function-in-humans-a-randomised-controlled-double-masked-cross-over-intervention-study
#5
Catarina Rendeiro, Honglin Dong, Caroline Saunders, Laura Harkness, Melvin Blaze, Yanpeng Hou, Ronald L Belanger, Giulia Corona, Julie A Lovegrove, Jeremy P E Spencer
Specific flavonoid-rich foods/beverages are reported to exert positive effects on vascular function; however, data relating to effects in the postprandial state are limited. The present study investigated the postprandial, time-dependent (0-7 h) impact of citrus flavanone intake on vascular function. An acute, randomised, controlled, double-masked, cross-over intervention study was conducted by including middle-aged healthy men (30-65 years, n 28) to assess the impact of flavanone intake (orange juice: 128·9 mg; flavanone-rich orange juice: 272·1 mg; homogenised whole orange: 452·8 mg; isoenergetic control: 0 mg flavanones) on postprandial (double meal delivering a total of 81 g of fat) endothelial function...
December 2016: British Journal of Nutrition
https://www.readbyqxmd.com/read/28062933/single-cycle-induction-chemotherapy-for-resectable-advanced-hypopharyngeal-cancer
#6
Torahiko Nakashima, Ryuji Yasumatsu, Kaori Asai, Hideoki Uryu, Ryunosuke Kogo, Takashi Nakagawa
BACKGROUND: The role of induction chemotherapy (IC) in the treatment of resectable advanced head and neck squamous cell carcinoma has not been elucidated, and the most effective IC regimen for chemoselection is still unknown. At our institute we have not used the triple combination of docetaxel, cisplatin, fluorouracil (TPF) for chemoselection, but rather the double combination of docetaxel + cisplatin (TP). The aim of this study is to report the outcome of patients with advanced hypopharyngeal cancer treated by single cycle of IC with TP followed by chemoradiation (CRT) or surgery...
January 6, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28061421/low-cost-and-facile-fabrication-of-a-paper-based-capillary-electrophoresis-microdevice-for-pathogen-detection
#7
Jee Won Lee, Dohwan Lee, Yong Tae Kim, Eun Yeol Lee, Do Hyun Kim, Tae Seok Seo
This paper describes the development of a novel paper-based capillary electrophoresis (pCE) microdevice using mineral paper, which is durable, oil and tear resistant, and waterproof. The pCE device is inexpensive (~$1.6 per device for materials), simple to fabricate, lightweight, and disposable, so it is more adequate for point-of-care (POC) pathogen diagnostics than a conventional CE device made of glass, quartz, silicon or polymer. In addition, the entire fabrication process can be completed within 1h without using expensive clean room facilities and cumbersome photolithography procedures...
December 28, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28059438/optimized-method-for-isolating-highly-purified-and-functional-porcine-aortic-endothelial-and-smooth-muscle-cells
#8
Farideh Beigi, Mitalben Patel, Marco A Morales-Garza, Caitlin Winebrenner, Andrea S Gobin, Eric Chau, Luiz C Sampaio, Doris A Taylor
BACKGROUND: Numerous protocols exist for isolating aortic endothelial and smooth muscle cells from small animals. However, establishing a protocol for isolating pure cell populations from large animal vessels that are more elastic has been challenging. We developed a simple sequential enzymatic approach to isolate highly purified populations of porcine aortic endothelial and smooth muscle cells. METHODS: The lumen of a porcine aorta was filled with 25 U/mL dispase solution and incubated at 37°C to dissociate the endothelial cells...
January 6, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28054684/sandwich-and-half-sandwich-metal-complexes-derived-from-cross-conjugated-3-methylene-penta-1-4-diynes
#9
Kevin B Vincent, Josef B G Gluyas, Qiang Zeng, Dmitry S Yufit, Judith A K Howard, František Hartl, Paul J Low
The cross-conjugated ethynyl-vinylidene [Ph2C[double bond, length as m-dash]C(C[triple bond, length as m-dash]CH){C(H)[double bond, length as m-dash]CRu(PPh3)2Cp}]PF6 ([4a]PF6), and [FcC(H)[double bond, length as m-dash]C(C[triple bond, length as m-dash]CH){C(H)[double bond, length as m-dash]CRu(PPh3)2Cp}]PF6 ([4b]PF6), and ethynyl-alkynyl Ph2C[double bond, length as m-dash]C(C[triple bond, length as m-dash]CH){C[triple bond, length as m-dash]CRu(PPh3)2Cp} (5a), and FcC(H)[double bond, length as m-dash]C(C[triple bond, length as m-dash]CH){C[triple bond, length as m-dash]CRu(PPh3)2Cp} (5b) compounds (Cp = η(5)-cyclopentadienyl) have been prepared from reactions of the known 3-methylene-penta-1,4-diynes Ph2C[double bond, length as m-dash]C(C[triple bond, length as m-dash]CH)2 (3a) and [FcCH[double bond, length as m-dash]C(C[triple bond, length as m-dash]CH)2] (3b) with [RuCl(PPh3)2Cp]...
January 5, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28051874/effects-of-a-passive-online-software-application-on-heart-rate-variability-and-autonomic-nervous-system-balance
#10
Beverly Rubik
OBJECTIVE: This study investigated whether short-term exposure to a passive online software application of purported subtle energy technology would affect heart rate variability (HRV) and associated autonomic nervous system measures. METHODS: This was a randomized, double-blinded, sham-controlled clinical trial (RCT). The study took place in a nonprofit laboratory in Emeryville, California. Twenty healthy, nonsmoking subjects (16 females), aged 40-75 years, participated...
January 4, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28051066/evolution-of-form-in-metal-organic-frameworks
#11
Jiyoung Lee, Ja Hun Kwak, Wonyoung Choe
Self-assembly has proven to be a widely successful synthetic strategy for functional materials, especially for metal-organic materials (MOMs), an emerging class of porous materials consisting of metal-organic frameworks (MOFs) and metal-organic polyhedra (MOPs). However, there are areas in MOM synthesis in which such self-assembly has not been fully utilized, such as controlling the interior of MOM crystals. Here we demonstrate sequential self-assembly strategy for synthesizing various forms of MOM crystals, including double-shell hollow MOMs, based on single-crystal to single-crystal transformation from MOP to MOF...
January 4, 2017: Nature Communications
https://www.readbyqxmd.com/read/28048273/su-f-i-70-investigation-of-gafchromic-ebt3-film-energy-dependence-using-proton-photon-and-electron-beams
#12
C Ferreira, E Schnell, S Ahmad, T De La Fuente Herman
PURPOSE: To investigate the energy dependence of Gafchromic EBT3 film over a range of clinically used proton, photon and electron energies. METHODS: Proton beam energies of 117 and 204 MeV, corresponding respectively to ranges in water of 10 cm and 27 cm from a Mevion S250 double scatter system unit were used. Electron energies of 6 and 20 MeV and photon energies of 6 and 18 MV from a Varian Clinac 21EX Linac were used. Two pieces of film (5×5 cm(2) ) were irradiated sequentially for doses of 100, 500, and 1000 cGy for all energies and modalities...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046697/su-f-j-203-retrospective-assessment-of-delivered-proton-dose-in-prostate-cancer-patients-based-on-daily-in-room-ct-imaging
#13
K Stuetzer, T Paessler, C Valentini, F Exner, J Thiele, T Hoelscher, M Krause, C Richter
PURPOSE: Retrospective calculation of the delivered proton dose in prostate cancer patients based on a unique dataset of daily CT images. METHODS: Inter-fractional motion in prostate cancer patients treated at our proton facility is counteracted by water-filled endorectal ballon and bladder filling protocol. Typical plans (XiO, Elekta Instruments AB, Stockholm) for 74 Gy(RBE) sequential boost treatment in 37 fractions include two series of opposing lateral double-scattered proton beams covering the respective iCTV...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28043758/-ebstein-s-like-anomaly-ventricular-double-inlet-a-rare-association
#14
Luis Muñoz Castellanos, Magdalena Kuri Nivon
INTRODUCTION AND OBJECTIVES: The association of univentricular heart with double inlet and Ebstein's "like" anomaly of the common atrioventricular valve is extremely rare. METHODS: Two hearts with this association are described with the segmental sequential system which determine the atrial situs, the types of atrioventricular and ventriculoarterial connections and associated anomalies. RESULTS: Both hearts had atrial situs solitus, and a univentricular heart with common atrioventricular valve, a foramen primum and double outlet ventricle with normal crossed great arteries...
December 30, 2016: Archivos de Cardiología de México
https://www.readbyqxmd.com/read/28035443/effect-of-mesh-width-on-apical-support-after-sacrocolpopexy
#15
Sunil Balgobin, Joseph L Fitzwater, Donald D McIntire, Imelda J Delgado, Clifford Y Wai
INTRODUCTION AND HYPOTHESIS: We evaluated the effect of polypropylene mesh width on vaginal apical support, mesh elongation, and mesh tensile strength for abdominal sacrocolpopexy. METHODS: Abdominal sacrocolpopexy was performed on ten cadavers using pieces of polypropylene mesh of width 1, 2, and 3 cm. Weights of 1, 2, 3, and 4 kg were sequentially applied to the vagina. The total distance moved by the vaginal apex, and the amount of stretch of the intervening mesh segment between the sacrum and the vagina were recorded for each width...
December 29, 2016: International Urogynecology Journal
https://www.readbyqxmd.com/read/28029173/a-randomized-trial-evaluating-whether-topiramate-aids-smoking-cessation-and-prevents-alcohol-relapse-in-recovering-alcohol-dependent-men
#16
Robert M Anthenelli, Jaimee L Heffner, Esther Wong, Jessie Tibbs, Katie Russell, Melodie Isgro, Elizabeth Dinh, Chris Wehrle, Matthew J Worley, Neal Doran
BACKGROUND: Alcohol and nicotine dependence frequently co-occur, and quitting smoking might enhance long-term alcohol abstinence. Topiramate appears to help non-alcohol-dependent individuals quit smoking, and our pilot work suggested efficacy only in men. It also prevents relapse to alcohol in recently detoxified alcoholics. We evaluated topiramate in abstinent alcohol-dependent men to assess whether this medication (i) promotes smoking cessation and (ii) prevents alcohol and other drug relapse in the context of smoking cessation treatment...
December 28, 2016: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28017399/safety-and-immunogenicity-of-a-recombinant-adenovirus-type-5-vector-based-ebola-vaccine-in-healthy-adults-in-sierra-leone-a-single-centre-randomised-double-blind-placebo-controlled-phase-2-trial
#17
Feng-Cai Zhu, Alie H Wurie, Li-Hua Hou, Qi Liang, Yu-Hua Li, James B W Russell, Shi-Po Wu, Jing-Xin Li, Yue-Mei Hu, Qiang Guo, Wen-Bo Xu, Abdul R Wurie, Wen-Juan Wang, Zhe Zhang, Wen-Jiao Yin, Manal Ghazzawi, Xu Zhang, Lei Duan, Jun-Zhi Wang, Wei Chen
BACKGROUND: A recombinant adenovirus type-5 vector-based vaccine expressing the glycoprotein of Ebola Zaire Makona variant showed good safety and immunogenicity in a phase 1 trial of healthy Chinese adults. We aimed to assess the safety and immunogenicity of this vaccine in healthy adults in Sierra Leone and to determine the optimal dose. METHODS: We did a single-centre, randomised, double-blind, placebo-controlled, phase 2 clinical trial at Sierra Leone-China Friendship Hospital, Freetown, Sierra Leone...
December 22, 2016: Lancet
https://www.readbyqxmd.com/read/28012635/the-effect-of-capsulotomy-and-capsular-repair-on-hip-distraction-a-cadaveric-investigation
#18
M Michael Khair, Jeffrey S Grzybowski, Benjamin D Kuhns, Thomas H Wuerz, Elizabeth Shewman, Shane J Nho
PURPOSE: To quantify how increasing interportal capsulotomy size affects the force required to distract the hip and to biomechanically compare simple side-to-side suture repair to acetabular-based suture anchors as capsular repair techniques. METHODS: Twelve fresh-frozen cadaveric hip specimens were dissected to the capsuloligamentous complex of the hip joint and fixed in a material testing system, such that a pure axial distraction of the iliofemoral ligament could be achieved...
December 22, 2016: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28009472/effects-on-%C3%AE-and-%C3%AE-cell-function-of-sequentially-adding-empagliflozin-and-linagliptin-to-therapy-in-people-with-type-2-diabetes-previously-receiving-metformin-an-exploratory-mechanistic-study
#19
Thomas Forst, Alexander Falk, Grit Andersen, Annelie Fischer, Matthias M Weber, Stephan Voswinkel, Tim Heise, Christoph Kapitza, Leona Plum-Mörschel
AIMS: To investigate the effect of sequential treatment escalation with empagliflozin and linagliptin on laboratory markers of α- and β-cell function in people with type 2 diabetes mellitus (T2DM) insufficiently controlled on metformin monotherapy. RESEARCH DESIGN AND METHODS: A total of 44 people with T2DM received 25 mg empagliflozin for a duration of 1 month in an open-label fashion (treatment period 1 [TP1]). Thereafter, they were randomized to a double-blind add-on therapy with linagliptin 5 mg or placebo (treatment period 2 [TP2]) for 1 additional month...
December 23, 2016: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28002471/dose-finding-study-of-omeprazole-on-gastric-ph-in-neonates-with-gastro-esophageal-acid-reflux-using-a-bayesian-sequential-approach
#20
Florentia Kaguelidou, Corinne Alberti, Valerie Biran, Olivier Bourdon, Caroline Farnoux, Sarah Zohar, Evelyne Jacqz-Aigrain
OBJECTIVE: Proton pump inhibitors are frequently administered on clinical symptoms in neonates but benefit remains controversial. Clinical trials validating omeprazole dosage in neonates are limited. The objective of this trial was to determine the minimum effective dose (MED) of omeprazole to treat pathological acid reflux in neonates using reflux index as surrogate marker. DESIGN: Double blind dose-finding trial with continual reassessment method of individual dose administration using a Bayesian approach, aiming to select drug dose as close as possible to the predefined target level of efficacy (with a credibility interval of 95%)...
2016: PloS One
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