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https://www.readbyqxmd.com/read/29679176/a-versatile-vector-toolkit-for-functional-analysis-of-rice-genes
#1
Feng He, Fan Zhang, Wenxian Sun, Yuese Ning, Guo-Liang Wang
BACKGROUND: Rice (Oryza sativa) is the main food for half of the world's population, and is considered the model for molecular biology studies of monocotyledon species. Although the rice genome was completely sequenced about 15 years ago, the function of most rice genes is still unknown. RESULTS: In this study, we developed a vector toolkit that contains 42 vectors for transient expression studies in rice protoplasts and stable expression analysis in transgenic rice...
April 20, 2018: Rice
https://www.readbyqxmd.com/read/29678945/ers-ecdc-statement-european-union-standards-for-tuberculosis-care-2017-update
#2
G B Migliori, G Sotgiu, S Rosales-Klintz, R Centis, L D'Ambrosio, I Abubakar, G Bothamley, J A Caminero, D M Cirillo, M Dara, G de Vries, S Aliberti, A T Dinh-Xuan, R Duarte, F Midulla, I Solovic, D Subotic, M Amicosante, A M Correira, A Cirule, G Gualano, H Kunst, F Palmieri, V Riekstina, S Tiberi, R Verduin, M J van der Werf
The International Standards for Tuberculosis (TB) Care define the essential level of care for managing patients who have or are presumed to have TB, or are at increased risk of developing the disease. The resources and capacity in the European Union and the European Economic Area (EU/EEA) permit higher standards of care to secure quality and timely TB diagnosis, prevention and treatment. On this basis, the European Union Standards for Tuberculosis Care (ESTC) were published in 2012 as standards specifically tailored to the EU-setting...
April 20, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29678510/corrigendum-to-dual-chemotactic-factors-secreting-human-amniotic-mesenchymal-stem-cells-via-talen-mediated-gene-editing-enhanced-angiogenesis-int-j-cardiol-260-2018-156-162
#3
In Sil Jeong, Youngjin Park, Hyun Aae Ryu, Hyun Sook An, Ju Hye Han, Sung-Whan Kim
No abstract text is available yet for this article.
April 18, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29678456/inflatable-penile-prosthesis-placement-scratch-technique-and-postoperative-vacuum-therapy-as-a-combined-approach-in-the-definitive-treatment-of-patients-with-peyronie-s-disease
#4
G Antonini, E De Berardinis, F Del Giudice, G M Busetto, S Lauretti, R Fragas, B I Chung, S L Conti, D Giannarelli, I Sperduti, M S Gross, P E Perito
PURPOSE: Peyronie's disease (PD) is a devastating condition resulting in penile deformity, erectile dysfunction (ED), pain and emotional distress. This prospective two institution study evaluates a multimodal surgical and mechanical combined approach in the definitive treatment of PD and concomitant ED. MATERIALS AND METHODS: 145 selected patients underwent endocavernosal disruption of the PD plaques via the "scratch technique" followed by inflatable penile prosthesis (IPP) insertion...
April 17, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29678427/the-psychological-impact-of-adult-traumatic-brachial-plexus-injury
#5
Zoe A Landers, Rishabh Jethanandani, Steve K Lee, Carol A Mancuso, Mavis Seehaus, Scott W Wolfe
PURPOSE: There is a high incidence of posttraumatic stress disorder (PTSD), depression, suicide risk, and psychological distress after orthopedic trauma and hand and upper-extremity injury. Although patients with traumatic adult brachial plexus injury are particularly vulnerable to psychologic distress, minimal clinical data exist about this cohort of patients. In this study, we sought to discover the prevalence of depression, PTSD, suicidal ideation, and substance abuse. METHODS: Between February, 2013 and July, 2014, during scheduled preoperative and/or postoperative appointments, the social worker at a metropolitan brachial plexus center conducted psychosocial assessments and questionnaire assessments of 21 patients evaluating for PTSD, depression, and substance use using 3 validated scales: PTSD Checklist-Specific, Patient Health Questionnaire-8, and National Institute on Drug Abuse Quick Screen...
April 17, 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29678199/megan-lr-new-algorithms-allow-accurate-binning-and-easy-interactive-exploration-of-metagenomic-long-reads-and-contigs
#6
Daniel H Huson, Benjamin Albrecht, Caner Bağcı, Irina Bessarab, Anna Górska, Dino Jolic, Rohan B H Williams
BACKGROUND: There are numerous computational tools for taxonomic or functional analysis of microbiome samples, optimized to run on hundreds of millions of short, high quality sequencing reads. Programs such as MEGAN allow the user to interactively navigate these large datasets. Long read sequencing technologies continue to improve and produce increasing numbers of longer reads (of varying lengths in the range of 10k-1M bps, say), but of low quality. There is an increasing interest in using long reads in microbiome sequencing, and there is a need to adapt short read tools to long read datasets...
April 20, 2018: Biology Direct
https://www.readbyqxmd.com/read/29678090/a-system-for-supporting-development-and-update-of-the-international-classification-of-health-interventions-ichi
#7
Marc Donada, Vincenzo Della Mea, Megan Cumerlato, Nicole Rankin, Richard Madden
The International Classification of Health Interventions (ICHI) is a member of the WHO Family of International Classifications, being developed to provide a common tool for reporting and analysing health interventions for statistical purposes. A web-based platform for classification development and update has been specifically developed to support the initial development step and then, after final approval, the continuous revision and update of the classification. The platform provides features for classification editing, versioning, comment management and URI identifiers...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29678022/using-rdf-and-git-to-realize-a-collaborative-metadata-repository
#8
Mark R Stöhr, Raphael W Majeed, Andreas Günther
The German Center for Lung Research (DZL) is a research network with the aim of researching respiratory diseases. The participating study sites' register data differs in terms of software and coding system as well as data field coverage. To perform meaningful consortium-wide queries through one single interface, a uniform conceptual structure is required covering the DZL common data elements. No single existing terminology includes all our concepts. Potential candidates such as LOINC and SNOMED only cover specific subject areas or are not granular enough for our needs...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29677569/validation-of-the-ajcc-8th-prognostic-system-for-breast-cancer-in-an-asian-healthcare-setting
#9
R X Wong, F Y Wong, John Lim, W X Lian, Y S Yap
AIMS: We aim to validate the AJCC 8th edition prognostic staging system for breast cancer in an Asian setting. METHODS: Clinico-pathologic information and cancer-specific survival (CSS) outcomes of 6287 stage I to III patients with invasive breast cancer who underwent upfront surgery at SingHealth institutions in Singapore from 2006 to 2014 were analyzed. Survival distributions for the different staging systems were estimated by the Kaplan-Meier method and compared using the log-rank tests...
April 17, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29676720/mutagenic-repair-of-double-stranded-dna-breaks-in-vaccinia-virus-genomes-requires-cellular-dna-ligase-iv-activity-in-the-cytosol
#10
Rutger David Luteijn, Ingo Drexler, Geoffrey L Smith, Robert Jan Lebbink, Emmanuel J H J Wiertz
Poxviruses comprise a group of large dsDNA viruses that include members relevant to human and animal health, such as variola virus, monkeypox virus, cowpox virus and vaccinia virus (VACV). Poxviruses are remarkable for their unique replication cycle, which is restricted to the cytoplasm of infected cells. The independence from the host nucleus requires poxviruses to encode most of the enzymes involved in DNA replication, transcription and processing. Here, we use the CRISPR/Cas9 genome engineering system to induce DNA damage to VACV (strain Western Reserve) genomes...
April 20, 2018: Journal of General Virology
https://www.readbyqxmd.com/read/29676032/use-of-two-grnas-for-crispr-cas9-improves-bi-allelic-homologous-recombination-efficiency-in-mouse-embryonic-stem-cells
#11
Sandra Acosta, Luciano Fiore, Isabel Anna Carota, Guillermo Oliver
Targeted genome editing in mouse embryonic stem cells (ESCs) is a powerful resource to functionally characterize genes and regulatory elements. The use of the CRISPR/Cas9 genome editing approach has remarkably improved the time and efficiency of targeted recombination. However, the efficiency of this protocol is still far from ideal when aiming for bi-allelic homologous recombination, requiring at least two independent targeting recombination events. Here we describe an improved protocol that uses two gRNAs flanking the selected targeted region, leading to highly efficient homologous recombination in mouse ESCs...
April 20, 2018: Genesis: the Journal of Genetics and Development
https://www.readbyqxmd.com/read/29675936/pediatric-ganglioglioma-with-an-h3-k27m-mutation-arising-from-the-cervical-spinal-cord
#12
Tomohiro Okuda, Nobuhiro Hata, Satoshi O Suzuki, Koji Yoshimoto, Koichi Arimura, Takeo Amemiya, Yojiro Akagi, Daisuke Kuga, Utako Oba, Yuhki Koga, Shouichi Ohga, Toru Iwaki, Koji Iihara
The 2016 edition of the World Health Organization Classification of Tumors of the Central Nervous System introduced "diffuse midline glioma H3 K27M mutant" as a new diagnostic entity. These tumors predominately affect pediatric patients and arise from midline structures such as the brainstem, thalamus and spinal cord. Here, we report a rare patient with spinal ganglioglioma carrying an H3 K27M mutation. A 10-year-old boy presented with an intramedullary tumor in the cervical spinal cord. The lesion was partially removed and histologically diagnosed as ganglioglioma...
April 19, 2018: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/29675646/validation-of-the-8th-edition-of-the-ajcc-uicc-tnm-staging-system-for-tongue-squamous-cell-carcinoma
#13
Satoshi Kano, Tomohiro Sakashita, Nayuta Tsushima, Takatsugu Mizumachi, Akira Nakazono, Takayoshi Suzuki, Shinichiro Yasukawa, Akihiro Homma
BACKGROUND: The revised 8th edition of the AJCC/UICC staging system was released in January 2017, and depth of invasion (DOI) was added to the new criteria for T classification in oral cavity cancer. In this study, we evaluated whether the 8th edition presents the prognosis and risk of nodal metastasis in patients with squamous cell carcinoma of tongue more accurately than did the 7th edition. METHODS: The data for 112 patients were obtained and reclassified based on the criteria presented in the 8th edition...
April 19, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29675030/homology-directed-repair-of-a-defective-glabrous-gene-in-arabidopsis-with-cas9-based-gene-targeting
#14
Florian Hahn, Marion Eisenhut, Otho Mantegazza, Andreas P M Weber
The CRISPR/Cas9 system has emerged as a powerful tool for targeted genome editing in plants and beyond. Double-strand breaks induced by the Cas9 enzyme are repaired by the cell's own repair machinery either by the non-homologous end joining pathway or by homologous recombination (HR). While the first repair mechanism results in random mutations at the double-strand break site, HR uses the genetic information from a highly homologous repair template as blueprint for repair of the break. By offering an artificial repair template, this pathway can be exploited to introduce specific changes at a site of choice in the genome...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29674992/memory-modulation-self-improvement-or-self-depletion
#15
Andrea Lavazza
Autobiographical memory is fundamental to the process of self-construction. Therefore, the possibility of modifying autobiographical memories, in particular with memory-modulation and memory-erasing, is a very important topic both from the theoretical and from the practical point of view. The aim of this paper is to illustrate the state of the art of some of the most promising areas of memory-modulation and memory-erasing, considering how they can affect the self and the overall balance of the "self and autobiographical memory" system...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29674865/dkey-software-for-editing-and-browsing-dichotomous-keys
#16
Adam Tofilski
Despite advances in computer technology and the increasing availability of multiple-access taxonomic keys, traditional dichotomous keys remain the most often used taxonomic identification tools. On the other hand, there seems to be a lack of an editor of dichotomous keys, which is both freely available and easy to use. The DKey software was developed in order to alleviate this problem. A taxonomic key in text format can be imported to the software in order to edit it. Various editing options are possible, including: moving couplets, removing couplets, combining keys and renumbering keys...
2018: ZooKeys
https://www.readbyqxmd.com/read/29673966/automated-search-of-control-points-in-surface-based-morphometry
#17
Antonietta Canna, Andrea G Russo, Sara Ponticorvo, Renzo Manara, Alessandro Pepino, Mario Sansone, Francesco Di Salle, Fabrizio Esposito
Cortical surface-based morphometry is based on a semi-automated analysis of structural MRI images. In FreeSurfer, a widespread tool for surface-based analyses, a visual check of gray-white matter borders is followed by the manual placement of control points to drive the topological correction (editing) of segmented data. A novel algorithm combining radial sampling and machine learning is presented for the automated control point search (ACPS). Four data sets with 3 T MRI structural images were used for ACPS validation, including raw data acquired twice in 36 healthy subjects and both raw and FreeSurfer preprocessed data of 125 healthy subjects from public databases...
April 16, 2018: NeuroImage
https://www.readbyqxmd.com/read/29673775/survival-of-patients-with-early-invasive-melanoma-down-staged-under-the-new-8-th-ajcc-edition
#18
Lena A von Schuckmann, Maria Celia B Hughes, Rebecca Lee, Paul Lorigan, Kiarash Khosrotehrani, B Mark Smithers, Adele C Green
No abstract text is available yet for this article.
April 16, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29673141/subunit-specific-role-of-nf-%C3%AE%C2%BAb-in-cancer
#19
REVIEW
Barbara Kaltschmidt, Johannes F W Greiner, Hussamadin M Kadhim, Christian Kaltschmidt
The transcription factor NF-κB is a key player in inflammation, cancer development, and progression. NF-κB stimulates cell proliferation, prevents apoptosis, and could promote tumor angiogenesis as well as metastasis. Extending the commonly accepted role of NF-κB in cancer formation and progression, different NF-κB subunits have been shown to be active and of particular importance in distinct types of cancer. Here, we summarize overexpression data of the NF-κB subunits RELA, RELB, and c-REL (referring to the v-REL, which is the oncogene of Reticuloendotheliosis virus strain T) as well as of their upstream kinase inhibitor, namely inhibitor of κB kinases (IKK), in different human cancers, assessed by database mining...
April 17, 2018: Biomedicines
https://www.readbyqxmd.com/read/29673028/cre-driver-lines-used-for-genetic-fate-mapping-of-neural-crest-cells-in-the-mouse-an-overview
#20
REVIEW
Julien Debbache, Vadims Parfejevs, Lukas Sommer
The neural crest is one of the embryonic structures with the broadest developmental potential in vertebrates. Morphologically, neural crest cells emerge during neurulation in the dorsal folds of the neural tube before undergoing an epithelial-to-mesenchymal transition (EMT), delaminating from the neural tube, and migrating to multiple sites in the growing embryo. Neural crest cells generate cell types as diverse as peripheral neurons and glia, melanocytes, and so-called mesectodermal derivatives that include craniofacial bone and cartilage and smooth muscle cells in cardiovascular structures...
April 19, 2018: Genesis: the Journal of Genetics and Development
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