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https://www.readbyqxmd.com/read/29138708/chondroma-of-the-bladder-an-atypical-localization
#1
M Tamayo-Jover, A Nazco-Deroy, R González-Álvarez, H Álvarez-Argüelles Cabrera, B Padilla-Fernández, T Concepción-Masip
Chondroma is a benign tumour of mesenchymal origin that is composed of cartilage and rarely located in soft tissues, being described so far only in four cases, as located in the bladder, according to our knowledge. We describe the fifth case of a 67-year-old woman who consulted for microscopic haematuria, with an endoscopic finding of submucosal nodular image in the anterior wall of the bladder, which after resection and the histologic study shows cartilage and fibroconnective tissue, in part hyalinised, and positive immunohistochemical staining of cells with vimentin and S-100; this fact can support the diagnosis of bladder chondroma...
2017: Case Reports in Urology
https://www.readbyqxmd.com/read/29133939/precision-medicine-for-urothelial-bladder-cancer-update-on-tumour-genomics-and-immunotherapy
#2
REVIEW
Kenneth M Felsenstein, Dan Theodorescu
Effective management of advanced urothelial bladder cancer is challenging. New discoveries that improve our understanding of molecular bladder cancer subtypes have revealed numerous potentially targetable genomic alterations and demonstrated the efficacy of treatments that harness the immune system. These findings have begun to change paradigms of bladder cancer therapy. For example, DNA repair pathway mutations in genes such as ERCC2, FANCC, ATM, RB1, and others can predict responses to neoadjuvant platinum-based chemotherapies and to targeted therapies on the basis of mutation status...
November 14, 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29123257/prostaglandin-receptors-induce-urothelial-tumourigenesis-as-well-as-bladder-cancer-progression-and-cisplatin-resistance-presumably-via-modulating-pten-expression
#3
Eiji Kashiwagi, Satoshi Inoue, Taichi Mizushima, Jinbo Chen, Hiroki Ide, Takashi Kawahara, Leonardo O Reis, Alexander S Baras, George J Netto, Hiroshi Miyamoto
BACKGROUND: We investigated the role of prostaglandin receptors (e.g. prostaglandin E2 receptor 2 (EP2), EP4) and the efficacy of celecoxib in urothelial tumourigenesis and cancer progression. METHODS: We performed immunohistochemistry in bladder cancer (BC) tissue microarrays, in vitro transformation assay in a normal urothelial SVHUC line, and western blot/reverse transcription-polymerase chain reaction/cell growth assays in BC lines. RESULTS: EP2/EP4 expression was elevated in BCs compared with non-neoplastic urothelial tissues and in BCs from those who were resistant to cisplatin-based neoadjuvant chemotherapy...
November 9, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29119069/targeting-the-tumor-assessing-the-impact-of-bladder-volume-and-position-on-accuracy-of-radiation-delivery-for-patients-with-bladder-cancer
#4
Andrew Kochan, Ryan Rivest, Katie Galloway, Pascal Lambert, Aldrich Ong, Rashmi Koul, Shahida Ahmed, Bashir Bashir, Harvey Quon
Context Daily variations in bladder size and position can negatively impact the ability to accurately deliver radiation. Aims We attempted to quantify how bladder volumes and positions change over the course of radiotherapy for muscle invasive bladder cancer and the planning target volume (PTV) margins required to account for such changes. Methods and material Cone-beam computed tomography (CT) images of 28 patients during their first, second, and third fractions and weekly thereafter were acquired. Bladders were contoured and the volume, centre of mass, and the maximal positions were recorded and compared to the planning CT scan...
September 1, 2017: Curēus
https://www.readbyqxmd.com/read/29116175/sniffer-mice-discriminate-urine-odours-of-patients-with-bladder-cancer-a-proof-of-principle-study-for-non-invasive-diagnosis-of-cancer-induced-odours
#5
Takaaki Sato, Yoji Katsuoka, Kimihiko Yoneda, Mitsuo Nonomura, Shinya Uchimoto, Reiko Kobayakawa, Ko Kobayakawa, Yoichi Mizutani
Similar to fingerprints, humans have unique, genetically determined body odours. In case of urine, the odour can change due to variations in diet as well as upon infection or tumour formation. We investigated the use of mice in a manner similar to "sniffer dogs" to detect changes in urine odour in patients with bladder cancer. We measured the odour discrimination thresholds of mice in a Y-maze, using urine mixtures from patients with bladder cancer (Stage I) and healthy volunteers (dietary variations) as well as occult blood- or antibiotic drug metabolite-modulated samples...
November 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29107992/software-assisted-dosimetry-in-peptide-receptor-radionuclide-therapy-with-177lutetium-dotatate-for-various-imaging-scenarios
#6
Dennis Kupitz, Christoph Wetz, Heiko Wissel, Florian Wedel, Ivayla Apostolova, Thekla Wallbaum, Jens Ricke, Holger Amthauer, Oliver S Grosser
In peptide receptor radionuclide therapy (PRRT) of patients with neuroendocrine neoplasias (NENs), intratherapeutic dosimetry is mandatory for organs at risk (e.g. kidneys) and tumours. We evaluated commercial dosimetry software (Dosimetry Toolkit) using varying imaging scenarios, based on planar and/or tomographic data, regarding the differences in calculated organ/tumour doses and the use for clinical routines. A total of 16 consecutive patients with NENs treated by PRRT with 177Lu-DOTATATE were retrospectively analysed...
2017: PloS One
https://www.readbyqxmd.com/read/29104786/non-muscle-invasive-bladder-cancer-are-epicrises-the-bermuda-triangle-of-information-transfer
#7
Steffen Lebentrau, Matthias May, Anne-Kathrin Wick, Michael Roiner, Marcella Mathew, Christian Gilfrich, Martin Schostak
Introduction: The aim of the study was to collect information regarding the quality of communication of risk-determining factors or risk profile, and the guideline conformity of recommendations for adjuvant treatment in patients with non-muscle invasive bladder cancer (NMIBC) between clinical and ambulatory urologists. Material and methods: At three German urological clinics during the period between 2012-2014, epicrises of 1,033 NMIBC-patients were retrospectively summarised to 505 tumour episodes (tumour resection including any re-resections) and analysed regarding the endpoints 1) risk profile is explicitly named or recorded risk factors are sufficient for the determination of risk profile, and 2) guideline conformity of treatment recommendation...
2017: Central European Journal of Urology
https://www.readbyqxmd.com/read/29101762/availability-and-patterns-of-intravesical-bcg-instillations
#8
S Awomir Poletajew, Aleksandra Majek, Piotr Magusiak, Katarzyna Ledzikowska, Bartosz Dybowski, Piotr Radziszewski
PURPOSE: Intravesical BCG instillations improve recurrence free survival in patients with non-muscle-invasive bladder cancer (NMIBC). METHODS: This is a national survey study, covering 223 urological centres, aimed at reliable identification of BCG availability and implemented treatment patterns. RESULTS: Response rate was 93.7%. BCG was used in 56.5% of urological departments. Another 22.7% referred patients to other hospitals for instillations, while 20...
November 4, 2017: Urology Journal
https://www.readbyqxmd.com/read/29101415/target-tailoring-and-proton-beam-therapy-to-reduce-small-bowel-dose-in-cervical-cancer-radiotherapy-a-comparison-of-benefits
#9
Peter de Boer, Agustinus J A J van de Schoot, Henrike Westerveld, Mark Smit, Marrije R Buist, Arjan Bel, Coen R N Rasch, Lukas J A Stalpers
PURPOSE: The aim of the study was to investigate the potential clinical benefit from both target tailoring by excluding the tumour-free proximal part of the uterus during image-guided adaptive radiotherapy (IGART) and improved dose conformity based on intensity-modulated proton therapy (IMPT). METHODS: The study included planning CTs from 11 previously treated patients with cervical cancer with a >4-cm tumour-free part of the proximal uterus on diagnostic magnetic resonance imaging (MRI)...
November 3, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29089607/the-anti-pd-1-era-an-opportunity-to-enhance-radiotherapy-for-patients-with-bladder-cancer
#10
REVIEW
Richard C Walshaw, Jamie Honeychurch, Timothy M Illidge, Ananya Choudhury
An urgent need exists to improve the outcomes of patients with muscle-invasive bladder cancer (MIBC), and especially of those with metastatic disease. Treatments that enhance antitumour immune responses - such as immune-checkpoint inhibition - provide an opportunity to do this. Despite initial success, durable response rates in patients with advanced-stage MIBC treated with novel inhibitory antibodies targeting programmed cell death protein 1 (PD-1) or its endogenous ligand programmed cell death 1 ligand 1 (PD-L1) remain low...
October 31, 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29074050/discrepancy-between-european-association-of-urology-guidelines-and-daily-practice-in-the-management-of-non-muscle-invasive-bladder-cancer-results-of-a-european-survey
#11
Kees Hendricksen, Atiqullah Aziz, Perrine Bes, Felix K-H Chun, Jakub Dobruch, Luis A Kluth, Paolo Gontero, Andrea Necchi, Aidan P Noon, Bas W G van Rhijn, Michael Rink, Florian Roghmann, Morgan Rouprêt, Roland Seiler, Shahrokh F Shariat, Brian Qvick, Marek Babjuk, Evanguelos Xylinas
BACKGROUND: The European Association of Urology (EAU) non-muscle-invasive bladder cancer (NMIBC) guidelines are meant to help minimise morbidity and improve the care of patients with NMIBC. However, there may be underuse of guideline-recommended care in this potentially curable cohort. OBJECTIVE: To assess European physicians' current practice in the management of NMIBC and evaluate its concordance with the EAU 2013 guidelines. DESIGN, SETTING, AND PARTICIPANTS: Initial 45-min telephone interviews were conducted with 20 urologists to develop a 26-item questionnaire for a 30-min online quantitative interview...
October 23, 2017: European Urology Focus
https://www.readbyqxmd.com/read/29071156/bipolar-vs-monopolar-resection-of-bladder-tumours-of-3%C3%A2-cm-in-patients-maintained-on-low-dose-aspirin-a-randomised-clinical-trial
#12
Mohamed M Hashad, Hussein M Abdeldaeim, Ahmed Moussa, Akram Assem, Tamer M Abou Youssif
OBJECTIVE: To compare the safety and efficacy of bipolar vs monopolar transurethral resection of bladder tumour (TURBT) in patients maintained on low-dose aspirin with tumours >3 cm. PATIENTS AND METHODS: A prospective randomised single-centre study was performed including 200 patients with bladder tumours of >3 cm, as measured by ultrasonography. All patients were using low-dose aspirin (81 mg/day), which was not stopped in the perioperative period. Patients were randomised into two groups: Group A, monopolar TURBT (M-TURBT); Group B, bipolar TURBT (B-TURBT)...
September 2017: Arab Journal of Urology
https://www.readbyqxmd.com/read/29071155/risk-factors-and-prognosis-of-intravesical-recurrence-after-surgical-management-of-upper-tract-urothelial-carcinoma-a-30-year-single-centre-experience
#13
Mohamed Mohamed Elawdy, Yasser Osman, Diaa Eldin Taha, Mohamed H Zahran, Samer El-Halwagy, Muftah El Garba, Ahmed M Harraz
OBJECTIVE: To review the incidence, predictors and prognosis of bladder cancer recurrence after management of upper tract urothelial carcinoma (UTUC). PATIENTS AND METHODS: We retrospectively reviewed patients who were surgically treated for UTUC from 1983 to 2013. The tumours were categorised according to the 1997 Tumour-Node-Metastasis (TNM) staging and the three-tiered World Health Organization grading systems. The primary endpoint was the occurrence of any intravesical recurrence after treatment...
September 2017: Arab Journal of Urology
https://www.readbyqxmd.com/read/29071149/laparoscopic-vs-robotic-nephroureterectomy-is-it-time-to-re-establish-the-standard-evidence-from-a-systematic-review
#14
REVIEW
Thomas Stonier, Nick Simson, Su-Min Lee, Ian Robertson, Tarik Amer, Bhaskar K Somani, Bhavan P Rai, Omar Aboumarzouk
OBJECTIVE: To conduct a systematic review of comparative studies of laparoscopic nephroureterectomy (LNU), the standard management for upper urothelial tumours, and robot-assisted NU (RANU) that has emerged as a viable alternative. METHODS: MEDLINE, EMBASE and the Cochrane Library were searched according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to identify all studies reporting on both LNU and RANU for upper urothelial tract tumours...
September 2017: Arab Journal of Urology
https://www.readbyqxmd.com/read/29064650/the-demographic-features-clinical-outcomes-prognosis-and-treatment-options-for-patients-with-sarcomatoid-carcinoma-of-the-urinary-bladder-a-single-centre-experience
#15
Simon Paul Robinson, Assad Farooq, Marc Laniado, Hanif Motiwala
INTRODUCTION: Carcinosarcoma of the bladder is a very rare neoplasm. The pathogenesis of carcinosarcomas is not clearly understood and remains a subject of debate. Whilst there is some research conceptualizing the histopathological findings of bladder carcinosarcomas, the demographic features, clinical outcomes, prognosis and treatment options remain unclear. MATERIALS AND METHODS: We analyzed 12 consecutive cases of patients with sarcoma-toid bladder cancer who were treated surgically at a single Urology Department be-tween 1999 and 2015...
October 24, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29050337/comprehensive-immune-transcriptomic-analysis-in-bladder-cancer-reveals-subtype-specific-immune-gene-expression-patterns-of-prognostic-relevance
#16
Runhan Ren, Kathrin Tyryshkin, Charles H Graham, Madhuri Koti, D Robert Siemens
Recent efforts on genome wide profiling of muscle invasive bladder cancer (MIBC) have led to its classification into distinct genomic and transcriptomic molecular subtypes that exhibit variability in prognosis. Evolving evidence from recent immunotherapy trials has demonstrated the significance of pre-existing tumour immune profiles that could guide treatment decisions. To identify immune gene expression patterns associated with the molecular subtypes, we performed a comprehensive in silico immune transcriptomic profiling, utilizing transcriptomic data from 347 MIBC cases from The Cancer Genome Atlas (TCGA)...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29032580/impact-of-ureteroscopy-before-radical-nephroureterectomy-for-upper-tract-urothelial-carcinomas-on-oncological-outcomes-a-meta-analysis
#17
Run-Qi Guo, Peng Hong, Geng-Yan Xiong, Lei Zhang, Dong Fang, Xue-Song Li, Kai Zhang, Li-Qun Zhou
OBJECTIVES: To investigate whether ureteroscopy (URS) before radical nephroureterectomy (RNU) for upper tract urothelial carcinomas (UTUCs) has an impact on oncological outcomes. PATIENTS AND METHODS: We performed a systematic literature search of PubMed, Web of Science, and EMBASE for citations published prior to September 2017 that described URS performed on patients with UTUC and conducted a standard meta-analysis on survival outcomes. RESULTS: Our meta-analysis included eight eligible studies containing 3975 patients...
October 15, 2017: BJU International
https://www.readbyqxmd.com/read/28983402/regulatory-t-cell-heterogeneity-and-the-cancer-immune-response
#18
REVIEW
Kirsten A Ward-Hartstonge, Roslyn A Kemp
The frequency of circulating or tumour-infiltrating regulatory T cells (Tregs) has been associated with poor patient survival in many cancers including breast, melanoma and lung. It has been hypothesised that Tregs impact the anti-tumour function of effector T cells, resulting in worse outcomes for patients. However, high infiltrates of Tregs have been associated with a positive outcome of patients in a minority of cancers including colorectal, bladder and oesophageal. In addition, many studies have shown no impact of Tregs in patient outcome...
September 2017: Clinical & Translational Immunology
https://www.readbyqxmd.com/read/28972965/hyaluronic-acid-family-in-bladder-cancer-potential-prognostic-biomarkers-and-therapeutic-targets
#19
Daley S Morera, Martin S Hennig, Asif Talukder, Soum D Lokeshwar, Jiaojiao Wang, Michael Garcia-Roig, Nicolas Ortiz, Travis J Yates, Luis E Lopez, Georgios Kallifatidis, Mario W Kramer, Andre R Jordan, Axel S Merseburger, Murugesan Manoharan, Mark S Soloway, Martha K Terris, Vinata B Lokeshwar
BACKGROUND: Molecular markers of clinical outcome may aid in designing targeted treatments for bladder cancer. However, only a few bladder cancer biomarkers have been examined as therapeutic targets. METHODS: Data from The Cancer Genome Atlas (TCGA) and bladder specimens were evaluated to determine the biomarker potential of the hyaluronic acid (HA) family of molecules - HA synthases, HA receptors and hyaluronidase. The therapeutic efficacy of 4-methylumbelliferone (4MU), a HA synthesis inhibitor, was evaluated in vitro and in xenograft models...
November 7, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28969401/narrow-band-imaging-nbi-cystoscopy-and-assisted-bipolar-turbt-a-preliminary-experience-in-a-single-centre
#20
Roberto Giulianelli, Barbara Cristina Gentile, Luca Albanesi, Paola Tariciotti, Gabriella Mirabile
OBJECTIVE: The aim of this study was to compare, in order to increase our ability to detect bladder cancer, the predictive power of narrow band imaging (NBI) versus white light cystoscopy (WL). The secondary objective was to evaluate how the preoperative use of NBI cystoscopy can increase the ability to detect bladder lesions in terms of status, multi-focality and dimensions. MATERIALS AND METHODS: Between June 2010 and April 2012, 797 consecutive patients, 423 male and 374 female, affected by suspected bladder cancer lesions, underwent to WL plus NBI cystoscopy and subsequently to WL Bipolar Gyrus PK (Olympus, Tokyo, Japan) transurethral resection of bladder tumour (WL-TURBT)...
October 3, 2017: Archivio Italiano di Urologia, Andrologia
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