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https://www.readbyqxmd.com/read/29776418/the-impact-of-contour-variation-on-tumour-control-probability-in-anal-cancer
#1
Michael P Jones, Jarad Martin, Kerwyn Foo, Patrick Estoesta, Lois Holloway, Michael Jameson
BACKGROUND: While intensity modulated radiotherapy (IMRT) has been widely adopted for the treatment of anal cancer (AC), the added contour complexity poses potential risks. This study investigates the impact of contour variation on tumour control probability (TCP) when using IMRT for AC. METHODS: Nine Australian centres contoured a single computed tomography dataset of a patient with AC. The same optimised template-based IMRT planning protocol was applied to each contour set to generate nine representative treatment plans and their corresponding dose volume histograms...
May 18, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29772880/detection-of-spatial-aggregation-of-cases-of-cancer-from-data-on-patients-and-health-centres-contained-in-the-minimum-basic-data-set
#2
Pablo Fernández-Navarro, Jose-Miguel Sanz-Anquela, Angel Sánchez Pinilla, Rosario Arenas Mayorga, Carmen Salido-Campos, Gonzalo López-Abente
The feasibility of the Minimum Basic Data Set (MBDS) as a tool in cancer research was explored monitoring its incidence through the detection of spatial clusters. Case-control studies based on MBDS and marked point process were carried out with the focus on the residence of patients from the Prince of Asturias University Hospital in Alcalá de Henares (Madrid, Spain). Patients older than 39 years with diagnoses of stomach, colorectal, lung, breast, prostate, bladder and kidney cancer, melanoma and haematological tumours were selected...
May 7, 2018: Geospatial Health
https://www.readbyqxmd.com/read/29770881/robot-assisted-laparoscopic-resection-of-clinical-t4b-tumours-of-distal-sigmoid-and-rectum-initial-results
#3
Rogier M P H Crolla, Janneke J C Tersteeg, George P van der Schelling, Jan H Wijsman, Jennifer M J Schreinemakers
BACKGROUND: Radical resection by multivisceral resection of colorectal T4 tumours is important to reduce local recurrence and improve survival. Oncological safety of laparoscopic resection of T4 tumours is controversial. However, robot-assisted resections might have advantages, such as 3D view and greater range of motion of instruments. The aim of this study is to evaluate the initial results of robot-assisted resection of T4 rectal and distal sigmoid tumours. METHODS: This is a cohort study of a prospectively kept database of all robot-assisted rectal and sigmoid resections between 2012 and 2017...
May 16, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29764851/inflammatory-myofibroblastic-tumour-an-unusual-presentation-including-small-bowel-obstruction-and-palpable-abdominal-mass
#4
Emily Cerier, Eliza Wright Beal, Mary E Dillhoff
A 41-year-old man with no medical history presented with 2 weeks of nausea, vomiting, a new palpable abdominal mass, constipation and a 14kgweight loss. On admission, CT abdomen and pelvis demonstrated a 6.9×3.7 cm soft-tissue abdominal mass deep to and invading the lower anterior abdominal wall with tethering of the urinary bladder and potential involvement of the urachus. Subsequently, a biopsy demonstrated a low-grade spindle cell neoplasm compatible with inflammatory myofibroblastic tumour with immunostain positive for smooth muscle actin and desmin and negative for CD21, CD117, DOG-1, TKE-1, mdm2, CD34 and ALK...
May 15, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29758554/psychosocial-distress-in-bladder-cancer-stratified-by-gender-age-treatment-and-tumour-stage
#5
Désirée Louise Draeger, Karl-Dietrich Sievert, Oliver W Hakenberg
OBJECTIVES: Cancer patients have to cope with anxieties -concerning their prognosis, potential recurrence/progression, and treatment-associated sequelae. Stress-related psychosocial factors influence survival and disease-related mortality in cancer patients. Despite improvements in diagnosis and treatment, bladder cancer (BC) remains characterized by high rates of recurrence and progression. We screened -pre-therapeutically the stress level of BC patients stratified by gender, disease state, treatment, and other factors by -self-administered validated questionnaires to integrate them into psychosocial support as needed...
May 14, 2018: Urologia Internationalis
https://www.readbyqxmd.com/read/29755117/safety-anti-tumour-activity-and-pharmacokinetics-of-fixed-dose-shr-1210-an-anti-pd-1-antibody-in-advanced-solid-tumours-a-dose-escalation-phase-1-study
#6
Hongnan Mo, Jing Huang, Jiachen Xu, Xuelian Chen, Dawei Wu, Dong Qu, Xi Wang, Bo Lan, Xingyuan Wang, Jianping Xu, Honggang Zhang, Yihebali Chi, Qing Yang, Binghe Xu
BACKGROUND: To assess the safety profile, pharmacokinetics, pharmacodynamics and preliminary antitumour activity of fixed-dose SHR-1210, a novel anti-PD-1 antibody, in advanced solid tumours. METHODS: A total of 36 patients with advanced solid tumours received intravenous SHR-1210 at 60 mg, 200 mg and 400 mg (4-week interval after first dose followed by a 2-week schedule) until disease progression or intolerable toxicity. The concentration of SHR-1210 was detected for pharmacokinetics, and receptor occupancy on circulating T lymphocytes was assessed for pharmacodynamics...
May 14, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29749774/bladder-cancer-overview-and-disease-management-part-1-non-muscle-invasive-bladder-cancer
#7
Beverley Anderson
Part 1 of this two-part article provides an overview of bladder cancer and discusses its management. Since publication of a previous article entitled 'Understanding the role of smoking in the aetiology of bladder cancer' ( Anderson, 2009 ), the author has received many requests for an update. This article provides an overview of bladder cancer and its current management practices, underlining the continued role of smoking as the predominant risk factor in the disease's development. The management of bladder cancer is governed by specific guidelines...
May 10, 2018: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/29749360/utility-of-cystatin-c-as-a-potential-bladder-tumour-biomarker-confirmed-by-surface-plasmon-resonance-technique
#8
Anna Tokarzewicz, Tomasz Guszcz, Anna Onopiuk, Robert Kozlowski, Ewa Gorodkiewicz
Background & objectives: The determination of cystatin C (cysC) may be helpful in diagnosis and monitoring of cancer because the pathogenesis of cancer is linked with an increased activity of cysteine peptidases (cathepsins) and a decrease of cysC concentration. This study was aimed to examine the utility of cysC as a marker of bladder cancer (BCa) to be used in the diagnosis. Methods: This study was conducted with 90 patients with BCa and 27 healthy people...
January 2018: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29745421/intradural-extramedullary-granular-cell-tumour-in-a-cat
#9
A Valentini, S Canal, M T Mandara, F Balducci, M Bernardini
A 7-year-old domestic shorthair cat was evaluated for progressive paraparesis, inability to jump, a paralysed tail and inability to void the bladder. Neurologic examination was consistent with a L4-S3 localisation. Survey radiographs of the lumbar vertebral column revealed L4-L7 vertebral body remodelling. A pre-contrast T1-weighted hyperintense, diffusely enhancing intradural lesion extending from L4 to S1 vertebral bodies was detected by MRI. Large, mesenchymal, round-to-polygonal cells arranged in nests or sheets were found on histologic examination at post mortem...
May 10, 2018: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/29743589/dual-inhibition-of-bcl-xl-and-mcl-1-is-required-to-induce-tumour-regression-in-lung-squamous-cell-carcinomas-sensitive-to-fgfr-inhibition
#10
Clare E Weeden, Casey Ah-Cann, Aliaksei Z Holik, Julie Pasquet, Jean-Marc Garnier, Delphine Merino, Guillaume Lessene, Marie-Liesse Asselin-Labat
Genetic alterations in the fibroblast growth factor receptors (FGFRs) have been described in multiple solid tumours including bladder cancer, head and neck and lung squamous cell carcinoma (SqCC). However, recent clinical trials showed limited efficacy of FGFR-targeted therapy in lung SqCC, suggesting combination therapy may be necessary to improve patient outcomes. Here we demonstrate that FGFR therapy primes SqCC for cell death by increasing the expression of the pro-apoptotic protein BIM. We therefore hypothesised that combining BH3-mimetics, potent inhibitors of pro-survival proteins, with FGFR-targeted therapy may enhance the killing of SqCC cells...
May 10, 2018: Oncogene
https://www.readbyqxmd.com/read/29729848/development-and-validation-of-a-28-gene-hypoxia-related-prognostic-signature-for-localized-prostate-cancer
#11
Lingjian Yang, Darren Roberts, Mandeep Takhar, Nicholas Erho, Becky A S Bibby, Niluja Thiruthaneeswaran, Vinayak Bhandari, Wei-Chen Cheng, Syed Haider, Amy M B McCorry, Darragh McArt, Suneil Jain, Mohammed Alshalalfa, Ashley Ross, Edward Schaffer, Robert B Den, R Jeffrey Karnes, Eric Klein, Peter J Hoskin, Stephen J Freedland, Alastair D Lamb, David E Neal, Francesca M Buffa, Robert G Bristow, Paul C Boutros, Elai Davicioni, Ananya Choudhury, Catharine M L West
BACKGROUND: Hypoxia is associated with a poor prognosis in prostate cancer. This work aimed to derive and validate a hypoxia-related mRNA signature for localized prostate cancer. METHOD: Hypoxia genes were identified in vitro via RNA-sequencing and combined with in vivo gene co-expression analysis to generate a signature. The signature was independently validated in eleven prostate cancer cohorts and a bladder cancer phase III randomized trial of radiotherapy alone or with carbogen and nicotinamide (CON)...
April 23, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29725126/in-the-bank-bladder-organoids-recapitulate-original-tumour
#12
Louise Stone
No abstract text is available yet for this article.
May 3, 2018: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29716617/focal-dose-escalation-for-prostate-cancer-using-68-ga-hbed-cc-psma-pet-ct-and-mri-a-planning-study-based-on-histology-reference
#13
Constantinos Zamboglou, Benedikt Thomann, Khodor Koubar, Peter Bronsert, Tobias Krauss, Hans C Rischke, Ilias Sachpazidis, Vanessa Drendel, Nasr Salman, Kathrin Reichel, Cordula A Jilg, Martin Werner, Philipp T Meyer, Michael Bock, Dimos Baltas, Anca L Grosu
BACKGROUND: Focal radiation therapy has gained of interest in treatment of patients with primary prostate cancer (PCa). The question of how to define the intraprostatic boost volume is still open. Previous studies showed that multiparametric MRI (mpMRI) or PSMA PET alone could be used for boost volume definition. However, other studies proposed that the combined usage of both has the highest sensitivity in detection of intraprostatic lesions. The aim of this study was to demonstrate the feasibility and to evaluate the tumour control probability (TCP) and normal tissue complication probability (NTCP) of radiation therapy dose painting using 68 Ga-HBED-CC PSMA PET/CT, mpMRI or the combination of both in primary PCa...
May 2, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29708967/metabolite-profiling-for-biomarkers-in-schistosoma-haematobium-infection-and-associated-bladder-pathologies
#14
Adewale S Adebayo, Swapnil D Mundhe, Henrietta O Awobode, Olugbenga S Onile, Atinuke M Agunloye, Raphael D Isokpehi, Yogesh S Shouche, Bayatigeri Santhakumari, Chiaka I Anumudu
BACKGROUND: Metabolic fingerprinting analysis can offer insights into underlying reactions in a biological system; hence it is crucial to the understanding of disease pathogenesis and could provide useful tools for discovering biomarkers. We sought to examine the urine and plasma metabolome in individuals affected by urogenital schistosomiasis and its associated-bladder pathologies. METHODOLOGY: Blood and midstream urine were obtained from volunteers who matched our inclusion criteria among residents from Eggua, southwestern Nigeria...
April 30, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29705676/a-case-of-retroperitoneal-desmoid-type-fibromatosis-that-involved-the-unilateral-ureter-after-gynaecologic-surgery
#15
Hitomi Ono, Kensuke Hori, Lena Tashima, Tomohiko Tsuruta, Shin-Ichi Nakatsuka, Kimihiko Ito
INTRODUCTION: Desmoid-type fibromatosis represents a rare, benign, soft tissue tumour that is locally invasive with high recurrence potential. PRESENTATION OF CASE: We encountered a case of retroperitoneal desmoid-type fibromatosis in a 45-year-old woman who presented with chief complaints of stomach ache and vomiting. She underwent total abdominal hysterectomy and left salpingo-oophorectomy due to uterine myoma and a paroophoritic cyst at 42 years of age. Abdominal computed tomography showed a 5-cm left retroperitoneal tumour and severe hydronephrosis of the left kidney...
March 29, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29702481/paeoniflorin-inhibits-the-growth-of-bladder-carcinoma-via-deactivation-of-stat3
#16
Jianhui Yang, Yu Ren, Zhong-Guan Lou, Xue Wan, Guo-Bin Weng, Dong Cen
Bladder cancer (BCa) is one of the most common urinary cancers. The present study aims to investigate whether Paeoniflorin (Pae) can exert inhibitory effects on BCa. The results showed that Pae inhibited proliferation of human BCa cell lines in a concentration- and time-dependent manner. Pae and cisplatin (Cis) synergistically inhibited the growth of tumours in RT4-bearing mice. Pae treatment neutralized the body loss induced by Cis. Moreover, Pae induced apoptosis in RT4 cells and increased the activities of caspase3, caspase8 and caspase9...
June 1, 2018: Acta Pharmaceutica
https://www.readbyqxmd.com/read/29694981/circrna-cdr1as-exerts-anti-oncogenic-functions-in-bladder-cancer-by-sponging-microrna-135a
#17
Peng Li, Xiao Yang, Wenbo Yuan, Chengdi Yang, Xiaolei Zhang, Jie Han, Jingzi Wang, Xiaheng Deng, Haiwei Yang, Pengchao Li, Jun Tao, Qiang Lu, Min Gu
BACKGROUND/AIMS: CircRNAs regulate gene expression in different malignancies. However, the role of Cdr1as in the tumourigenesis of bladder cancer and its potential mechanisms remain unknown. METHODS: qRT-PCR was used to detect Cdr1as and target miRNA expression in bladder cancer tissues and cell lines. Biological functional experiments were performed to detect the effects of Cdr1as on the biological behaviour of bladder cancer cells in vivo and in vitro. Bioinformatic analysis was utilised to predict potential miRNA target sites on Cdr1as...
April 20, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29693307/trans-anal-total-mesorectal-excision-is-it-really-safe-and-better-than-laparoscopic-total-mesorectal-excision-with-perineal-approach-first-in-patients-with-low-rectal-cancer-a-learning-curve-with-case-matched-study-in-68-patients
#18
Diane Mege, Elisabeth Hain, Zaher Lakkis, Léon Maggiori, Justine Prost À la Denise, Yves Panis
AIM: To compare learning curve of trans-anal total mesorectal excision (TATME) with laparoscopic TME started by perineal approach (LTME). METHOD: The first 34 consecutive patients who underwent TATME for low rectal cancer were matched with LTME performed by the same surgeon, for gender, body mass index and chemoradiation. RESULTS: 34 patients undergoing TATME (23 males; 58±14 years) were matched with 34 undergoing LTME (23 males; 59±13 years)...
April 25, 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/29684744/the-role-of-circulating-tumour-cells-and-nucleic-acids-in-blood-for-the-detection-of-bladder-cancer-a-systematic-review
#19
REVIEW
Pramit Khetrapal, Matthew Wei Liang Lee, Wei Shen Tan, Liqin Dong, Patricia de Winter, Andrew Feber, John D Kelly
BACKGROUND: Blood-based biomarkers are a neglected resource in bladder cancer, where the mainstay of focus has been on urinary biomarkers. However, blood-based biomarkers are gaining popularity in other solid cancers, particularly circulating tumour cells (CTCs) and circulating nucleic acids. In this systematic review, we identify and discuss the diagnostic value of CTC, cell-free DNA and RNA based biomarkers in bladder cancer. METHODS: A MEDLINE/Pubmed systematic search was performed using the following keywords: (bladder cancer) AND (blood OR plasma OR serum) AND biomarker AND (DNA OR RNA OR cfDNA OR cell-free DNA OR RNA OR CTC)...
April 17, 2018: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29681775/does-itv-vaginal-procedure-ensure-dosimetric-coverage-during-imrt-of-post-operative-gynaecological-tumours-without-instructions-concerning-rectal-filling
#20
Ramona Verges, Alexandra Giraldo, Alejandro Seoane, Elisabet Toral, M Carmen Ruiz, Ariadna Pons, Jordi Giralt
Aim: To find out whether the internal target volume (ITV) vaginal procedure ensures dosimetric coverage during intensity-modulated radiation therapy (IMRT) of post-operative gynaecological tumours without instructions on rectal filling. Background: The ITV vaginal procedure does not necessarily include all movements of the bladder, and does not include changes in the rectal volume. We should know if the vaginal ITV is a useful tool in maintaining CTV coverage during treatment...
March 2018: Reports of Practical Oncology and Radiotherapy
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