Yuanxu Guo, Zixin Min, Congshan Jiang, Wei Wang, Jidong Yan, Peng Xu, Ke Xu, Jing Xu, Mengyao Sun, Yitong Zhao, Safdar Hussain, Rui Zhang, Quancheng Wang, Yan Han, Fujun Zhang, Wenhua Zhu, Dongmin Li, Liesu Meng, Jian Sun, Shemin Lu
Osteoarthritis (OA) is the most common form of arthritis involving major structural changes of peripheral joints and local or systemic inflammation and in lack of therapeutic approaches because of complexity of underlying molecular basis. Our previous work showed that HS6ST2, an enzyme involved in the transfer of sulfate, is downregulated in cartilage tissues of OA patients compared with normal donors, but little is known about its regulatory mechanism. In this study, we demonstrated that the expression of HS6ST2 was lower in OA-damaged cartilage than smooth cartilage from the same patient...
June 13, 2018: Cell Death & Disease