Congshan Jiang, Xiaoying Wu, Xiaowei Li, Mengyao Li, Wentao Zhang, Pei Tao, Jing Xu, Xiaoyu Ren, Lingfei Mo, Yuanxu Guo, Si Wang, Manman Geng, Fujun Zhang, Juan Tian, Wenhua Zhu, Liesu Meng, Shemin Lu
MicroRNA-147 (miR-147) had been previously found induced in synoviocytes by inflammatory stimuli derived from T cells in experimental arthritis. This study was designed to verify whether loss of its function might alleviate inflammatory events in joints of experimental and rheumatoid arthritis (RA). DA rats were injected intradermally with pristane to induce arthritis, and rno-miR-147 antagomir was locally administrated into individual ankle compared with negative control or rno-miR-155-5p antagomir (potential positive control)...
April 17, 2021: European Journal of Immunology