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https://www.readbyqxmd.com/read/29719818/william-bradley-coley-md-and-the-phenomenon-of-spontaneous-regression
#1
REVIEW
Leonard F Vernon
The standard definition of spontaneous regression (SR) of cancer is as follows, "…when a malignant tumor partially or completely disappears without treatment or in the presence of therapy which is considered inadequate to exert a significant influence on neoplastic disease." SR is also known as Saint Peregrine tumor, the name taken from a young priest, Peregrine Laziosi (1260 [5]-1345, exact date is unknown), who had been diagnosed with a tumor of the tibia. The mass eventually grew so large that it broke through the skin and became severely infected...
2018: ImmunoTargets and Therapy
https://www.readbyqxmd.com/read/29715002/machine-learning-in-computer-aided-synthesis-planning
#2
Connor W Coley, William H Green, Klavs F Jensen
Computer-aided synthesis planning (CASP) is focused on the goal of accelerating the process by which chemists decide how to synthesize small molecule compounds. The ideal CASP program would take a molecular structure as input and output a sorted list of detailed reaction schemes that each connect that target to purchasable starting materials via a series of chemically feasible reaction steps. Early work in this field relied on expert-crafted reaction rules and heuristics to describe possible retrosynthetic disconnections and selectivity rules but suffered from incompleteness, infeasible suggestions, and human bias...
May 1, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29707204/loss-of-zbtb32-in-nod-mice-does-not-significantly-alter-t-cell-responses
#3
William D Coley, Yongge Zhao, Charles J Benck, Yi Liu, Chie Hotta-Iwamura, M Jubayer Rahman, Kristin V Tarbell
Background : We previously identified the transcriptional regulator Zbtb32 as a factor that can promote T cell tolerance in the Non-Obese Diabetic (NOD) mouse, a model of Type 1 diabetes. Antigen targeted to DCIR2 + dendritic cells (DCs) in vivo inhibited both diabetes and effector T cell expansion in NOD mice. Furthermore, Zbtb32 was preferentially induced in autoreactive CD4 T cells stimulated by these tolerogenic DCIR2 + DCs, and overexpression of Zbtb32 in islet-specific T cells inhibited the diabetes development by limiting T cell proliferation and cytokine production...
2018: F1000Research
https://www.readbyqxmd.com/read/29558182/the-evolving-state-of-medical-device-cybersecurity
#4
Suzanne Schwartz, Aftin Ross, Seth Carmody, Penny Chase, Steve Christey Coley, Julie Connolly, Cathy Petrozzino, Margie Zuk
No abstract text is available yet for this article.
March 2018: Biomedical Instrumentation & Technology
https://www.readbyqxmd.com/read/29480185/designing-an-internet-based-multidomain-intervention-for-the-prevention-of-cardiovascular-disease-and-cognitive-impairment-in-older-adults-the-hatice-trial
#5
Mariagnese Barbera, Francesca Mangialasche, Susan Jongstra, Juliette Guillemont, Tiia Ngandu, Cathrien Beishuizen, Nicola Coley, Carol Brayne, Sandrine Andrieu, Edo Richard, Hilkka Soininen, Miia Kivipelto
BACKGROUND: Many dementia and cardiovascular disease (CVD) cases in older adults are attributable to modifiable vascular and lifestyle-related risk factors, providing opportunities for prevention. In the Healthy Aging Through Internet Counselling in the Elderly (HATICE) randomized controlled trial, an internet-based multidomain intervention is being tested to improve the cardiovascular risk (CVR) profile of older adults. OBJECTIVE: To design a multidomain intervention to improve CVR, based on the guidelines for CVR management, and administered through a coach-supported, interactive, platform to over 2500 community-dwellers aged 65+ in three European countries...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29472896/bacterial-therapy-of-cancer-promises-limitations-and-insights-for-future-directions
#6
M Gabriela Kramer, Martín Masner, Fernando A Ferreira, Robert M Hoffman
Spontaneous tumors regression has been associated with microbial infection for 100s of years and inspired the use of bacteria for anticancer therapy. Dr. William B. Coley (1862-1936), a bone- sarcoma surgeon, was a pioneer in treating his patients with both live bacterial-based and mixture of heat-killed bacteria known as "Coley's toxins." Unfortunately, Coley was forced to stop his work which interrupted this field for about half a century. Currently, several species of bacteria are being developed against cancer...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29453850/the-role-of-the-immune-system-in-kidney-disease
#7
REVIEW
J Tecklenborg, D Clayton, S Siebert, S M Coley
The immune system and the kidneys are closely linked. In health the kidneys contribute to immune homeostasis, while components of the immune system mediate many acute forms of renal disease and play a central role in progression of chronic kidney disease. A dysregulated immune system can have either direct or indirect renal effects. Direct immune-mediated kidney diseases are usually a consequence of autoantibodies directed against a constituent renal antigen, such as collagen IV in anti-glomerular basement membrane disease...
May 2018: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29439835/low-cd25-on-autoreactive-tregs-impairs-tolerance-via-low-dose-il-2-and-antigen-delivery
#8
Chie Hotta-Iwamura, Charles Benck, William D Coley, Yi Liu, Yongge Zhao, Juan A Quiel, Kristin V Tarbell
Dendritic cell (DC)-mediated T cell tolerance deficiencies contribute to the pathogenesis of autoimmune diseases such as type 1 diabetes. Delivering self-antigen to dendritic-cell inhibitory receptor-2 (DCIR2)+ DCs can delay but not completely block diabetes development in NOD mice. These DCIR2-targeting antibodies induce tolerance via deletion and anergy, but do not increase islet-specific Tregs. Because low-dose IL-2 (LD-IL-2) administration can preferentially expand Tregs, we tested whether delivering islet-antigen to tolerogenic DCIR2+ DCs along with LD-IL-2 would boost islet-specific Tregs and further block autoimmunity...
February 10, 2018: Journal of Autoimmunity
https://www.readbyqxmd.com/read/29436716/chemocoding-as-an-identification-tool-where-morphological-and-dna-based-methods-fall-short-inga-as-a-case-study
#9
María-José Endara, Phyllis D Coley, Natasha L Wiggins, Dale L Forrister, Gordon C Younkin, James A Nicholls, R Toby Pennington, Kyle G Dexter, Catherine A Kidner, Graham N Stone, Thomas A Kursar
The need for species identification and taxonomic discovery has led to the development of innovative technologies for large-scale plant identification. DNA barcoding has been useful, but fails to distinguish among many species in species-rich plant genera, particularly in tropical regions. Here, we show that chemical fingerprinting, or 'chemocoding', has great potential for plant identification in challenging tropical biomes. Using untargeted metabolomics in combination with multivariate analysis, we constructed species-level fingerprints, which we define as chemocoding...
April 2018: New Phytologist
https://www.readbyqxmd.com/read/29429346/ligand-mediated-nanocrystal-growth
#10
Stefano Lazzari, Pius M Theiler, Yi Shen, Connor W Coley, Andreas Stemmer, Klavs F Jensen
A microfluidic platform combined with a deterministic model accounting for surface ligands reveals precious insights into the nanocrystal formation process. The comparison of on-line kinetic information with model predictions enables the derivation of temperature-dependent kinetic parameters for the CdSe model system. This fully generalizable approach represents a step forward toward a quantitative prediction of the nanocrystal size distribution, enabling the control and optimization of process performance and material properties...
March 13, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29428967/consequences-of-interspecific-variation-in-defenses-and-herbivore-host-choice-for-the-ecology-and-evolution-of-inga-a-speciose-rainforest-tree
#11
REVIEW
Phyllis D Coley, María-José Endara, Thomas A Kursar
We summarize work on a speciose Neotropical tree genus, Inga (Fabaceae), examining how interspecific variation in anti-herbivore defenses may have evolved, how defenses shape host choice by herbivores and how they might regulate community composition and influence species radiations. Defenses of expanding leaves include secondary metabolites, extrafloral nectaries, rapid leaf expansion, trichomes, and synchrony and timing of leaf production. These six classes of defenses are orthogonal, supporting independent evolutionary trajectories...
February 10, 2018: Oecologia
https://www.readbyqxmd.com/read/29425952/safety-of-therapeutic-fever-induction-in-cancer-patients-using-approved-pamp-drugs
#12
Uwe Rudolf Max Reuter, Ralf Oettmeier, Uwe Hobohm
William Coley, between 1895 and 1936, treated hundreds of cancer patients using infusions of fever inducing bacerial extracts. Similar experiments were done by Klyuyeva and co-workers in the 1940ies in Russia using trypanosoma extracts. Many remissions and cures were reported. We have conjectured that pathogen associated molecular pattern substances (PAMP) are the molecular explanation for the beneficial treatments in both groups. We could show that a combination of PAMP can eradicate solid tumours in cancer mice if applied several times...
April 2018: Translational Oncology
https://www.readbyqxmd.com/read/29405230/trajectory-of-the-mapt-pacc-preclinical-alzheimer-cognitive-composite-in-the-placebo-group-of-a-randomized-control-trial-results-from-the-mapt-study-lessons-for-further-trials
#13
J K Chhetri, P de Souto Barreto, C Cantet, M Cesari, N Coley, S Andrieu, B Vellas
Defining the primary cognitive endpoint is a major decision for Alzheimer's disease preventive trials. As an example for further trials we present in detail the three-year cognitive decline in the placebo group of MAPT trial, a randomized controlled trial (RCT) using a cognitive composite score (MAPT-PACC). Participants were dementia-free adults 70 years or older, with subjective memory complaints. Our findings as expected showed subjects with older age (>75), higher beta amyloid brain deposition, APOE-ε4 allele carriers, with low RBC DHA+EPA levels and higher CDR level are at higher risk of cognitive decline...
2018: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/29306183/child-maltreatment-re-offending-in-families-served-by-the-united-states-air-force-family-advocacy-program
#14
Randy J McCarthy, Joel S Milner, Sarah L Coley, LaJuana Ormsby, Mark Oliver
The current study examined child maltreatment re-offending in United States Air Force (USAF) families. In a clinical database containing 24,999 child maltreatment incidents perpetrated by 15,042 offenders between the years 1997 and 2013, 13% of offenders maltreated a child on more than one date (i.e., they re-offended). We explored several offender demographic characteristics associated with who re-offended and found that civilians re-offended at a similar rate as active duty members, males re-offended at a similar rate as females, and younger offenders were more likely to re-offend than older offenders...
March 2018: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29297609/proceedings-beyond-ultrasound-first-forum-on-improving-the-quality-of-ultrasound-imaging-in-obstetrics-and-gynecology
#15
Beryl R Benacerraf, Katherine K Minton, Carol B Benson, Bryann S Bromley, Brian D Coley, Peter M Doubilet, Wesley Lee, Samuel H Maslak, John S Pellerito, James J Perez, Eric Savitsky, Norman A Scarborough, Joseph Wax, Alfred Z Abuhamad
The Beyond Ultrasound First Forum was conceived to increase awareness that the quality of obstetric and gynecologic ultrasound can be improved, and is inconsistent throughout the country, likely due to multiple factors, including the lack of a standardized curriculum and competency assessment in ultrasound teaching. The forum brought together representatives from many professional associations; the imaging community including radiology, obstetrics and gynecology, and emergency medicine among others; in addition to government agencies, insurers, industry, and others with common interest in obstetric and gynecologic ultrasound...
January 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29296663/computer-assisted-retrosynthesis-based-on-molecular-similarity
#16
Connor W Coley, Luke Rogers, William H Green, Klavs F Jensen
We demonstrate molecular similarity to be a surprisingly effective metric for proposing and ranking one-step retrosynthetic disconnections based on analogy to precedent reactions. The developed approach mimics the retrosynthetic strategy defined implicitly by a corpus of known reactions without the need to encode any chemical knowledge. Using 40 000 reactions from the patent literature as a knowledge base, the recorded reactants are among the top 10 proposed precursors in 74.1% of 5000 test reactions, providing strong quantitative support for our methodology...
December 27, 2017: ACS Central Science
https://www.readbyqxmd.com/read/29208590/the-national-patient-centered-clinical-research-network-pcornet-bariatric-study-cohort-rationale-methods-and-baseline-characteristics
#17
Sengwee Toh, Laura J Rasmussen-Torvik, Emily E Harmata, Roy Pardee, Rosalinde Saizan, Elisha Malanga, Jessica L Sturtevant, Casie E Horgan, Jane Anau, Cheri D Janning, Robert D Wellman, R Yates Coley, Andrea J Cook, Anita P Courcoulas, Karen J Coleman, Neely A Williams, Kathleen M McTigue, David Arterburn, James McClay
BACKGROUND: Although bariatric procedures are commonly performed in clinical practice, long-term data on the comparative effectiveness and safety of different procedures on sustained weight loss, comorbidities, and adverse effects are limited, especially in important patient subgroups (eg, individuals with diabetes, older patients, adolescents, and minority patients). OBJECTIVE: The objective of this study was to create a population-based cohort of patients who underwent 3 commonly performed bariatric procedures-adjustable gastric band (AGB), Roux-en-Y gastric bypass (RYGB), and sleeve gastrectomy (SG)-to examine the long-term comparative effectiveness and safety of these procedures in both adults and adolescents...
December 5, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/29208354/more-than-a-number-perspectives-of-prenatal-care-quality-from-mothers-of-color-and-providers
#18
Sheryl L Coley, Jasmine Y Zapata, Rebecca J Schwei, Glen Ellen Mihalovic, Maya N Matabele, Elizabeth A Jacobs, Cynthie K Anderson
INTRODUCTION: African American mothers and other mothers of historically underserved populations consistently have higher rates of adverse birth outcomes than White mothers. Increasing prenatal care use among these mothers may reduce these disparities. Most prenatal care research focuses on prenatal care adequacy rather than concepts of quality. Even less research examines the dual perspectives of African American mothers and prenatal care providers. In this qualitative study, we compared perceptions of prenatal care quality between African American and mixed race mothers and prenatal care providers...
March 2018: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/29188863/cross-sectional-associations-of-total-plasma-homocysteine-with-cortical-%C3%AE-amyloid-independently-and-as-a-function-of-omega-3-polyunsaturated-fatty-acid-status-in-older-adults-at-risk-of-dementia
#19
C Hooper, P De Souto Barreto, N Coley, E Caussé, P Payoux, A S Salabert, M Cesari, S Andrieu, G-L Bowman, M Weiner, B Vellas
OBJECTIVES: Elevated total plasma homocysteine is a risk factor for Alzheimer's disease (AD) and there is some evidence that omega-3 polyunsaturated fatty acids (n-3 PUFAs) can modulate the effects of homocysteine-lowering B vitamins on AD related pathologies. Hence we investigated the relationship between total plasma homocysteine and cortical β-amyloid (Aβ) in older adults at risk of dementia. The role of erythrocyte membrane n-3 PUFAs (omega 3 index) on this relationship was also explored...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29169997/psd95-a-synaptic-protein-implicated-in-schizophrenia-or-autism
#20
REVIEW
Austin A Coley, Wen-Jun Gao
The molecular components of the postsynaptic density (PSD) in excitatory synapses of the brain are currently being investigated as one of the major etiologies of neurodevelopmental disorders such as schizophrenia (SCZ) and autism. Postsynaptic density protein-95 (PSD-95) is a major regulator of synaptic maturation by interacting, stabilizing and trafficking N-methyl-d-aspartic acid receptors (NMDARs) and α-amino-3-hydroxy-5-methyl-4-isox-azoleproprionic acid receptors (AMPARs) to the postsynaptic membrane...
March 2, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
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