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https://www.readbyqxmd.com/read/29093013/2017-william-b-coley-award
#1
(no author information available yet)
No abstract text is available yet for this article.
November 2017: Cancer Immunology Research
https://www.readbyqxmd.com/read/29083439/cognitive-changes-with-omega-3-polyunsaturated-fatty-acids-in-non-demented-older-adults-with-low-omega-3-index
#2
C Hooper, P De Souto Barreto, N Coley, C Cantet, M Cesari, S Andrieu, B Vellas
OBJECTIVES: To investigate the changes in specific domains of cognitive function in older adults reporting subjective memory complaints with a low omega-3 index receiving omega 3 polyunsaturated fatty acid (n-3 PUFA) supplementation or placebo. DESIGN: This is a secondary exploratory analysis of the Multidomain Alzheimer Preventive Trial (MAPT) using subjects randomized to the n-3 PUFA supplementation or placebo group. SETTING: French community dwellers aged 70 or over reporting subjective memory complaints, but free from clinical dementia...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29073335/in-situ-microfluidic-studies-of-bi-phasic-nanocrystal-ligand-exchange-reaction-using-oscillatory-flow-reactor
#3
Yi Shen, Milad Abolhasani, Yue Chen, Lisi Xie, Lu Yang, Connor Coley, Moungi Bawendi, Klavs F Jensen
Oscillatory flow reactors provide a surface energy-driven approach for automatically screening reaction conditions and studying reaction mechanisms of bi-phasic nanocrystal ligand exchange reactions. Sulfide and cysteine ligand exchange reactions with as-synthesized CdSe quantum dots (QDs) are chosen as two model reactions. Different reaction variables including the new-ligand-to-QD ratio, the size of the particles, and the original ligand type are examined systematically. Based on the in-situ obtained UV-Vis absorption spectra during the reaction, we propose two different exchange pathways for the sulfide exchange reaction...
October 26, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29063081/automated-microfluidic-platform-for-systematic-studies-of-colloidal-perovskite-nanocrystals-towards-continuous-nano-manufacturing
#4
Robert W Epps, Kobi C Felton, Connor W Coley, Milad Abolhasani
Colloidal organic/inorganic metal-halide perovskite nanocrystals have recently emerged as a potential low-cost replacement for the semiconductor materials in commercial photovoltaics and light emitting diodes. However, unlike III-V and IV-VI semiconductor nanocrystals, studies of colloidal perovskite nanocrystals have yet to develop a fundamental and comprehensive understanding of nucleation and growth kinetics. Here, we introduce a modular and automated microfluidic platform for the systematic studies of room-temperature synthesized cesium-lead halide perovskite nanocrystals...
October 24, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/29034781/point-of-care-testing-in-community-pharmacies-keys-to-success-from-pennsylvania-pharmacists
#5
Emily A Steltenpohl, Brandon K Barry, Kim C Coley, Melissa S McGivney, Julie L Olenak, Lucas A Berenbrok
BACKGROUND: Clinical Laboratory Improvement Amendments (CLIA)-waived tests allow for quick, accurate, and noninvasive laboratory testing. Community pharmacists utilize CLIA-waived tests to provide clinical services such as point-of-care (POC) testing to help manage chronic disease and acute illness. OBJECTIVE: To identify key themes in the successful delivery of POC testing services by community pharmacists in Pennsylvania. RESULTS: An initial search identified 51 Pennsylvania pharmacies with a CLIA waiver...
January 1, 2017: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28956916/driving-force-dependence-of-electron-transfer-from-electronically-excited-ir-cod-%C3%AE-me2pz-2-to-photo-acid-generators
#6
Wesley Sattler, Aaron A Rachford, Paul J LaBeaume, Suzanne M Coley, James W Thackeray, James F Cameron, Astrid M Müller, Jay R Winkler, Harry B Gray
We report the rates of electron transfer (ET) reactions of electronically excited [Ir(COD)(μ-Me2pz)]2 with onium salt photoacid generators (PAGs). The reduction potentials of the PAGs span a large electrochemical window that allows determination of the driving force dependence of the ET reactions. Rate constants of ET from electronically excited [Ir(COD)(μ-Me2pz)]2 to onium PAGs are determined by the reaction driving force until the diffusion limit in acetonitrile is reached.
September 28, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28935774/immunotherapy-a-new-and-old-approach-to-treatment-of-soft-tissue-and-bone-sarcomas
#7
REVIEW
Michael J Nathenson, Anthony P Conley, Edward Sausville
Soft tissue and bone sarcomas are a rare and heterogeneous form of cancer. With standard of care treatment options including surgery, radiation, and chemotherapy, the long-term survival is still low for high-risk soft tissue sarcoma patients. New treatment strategies are needed. Immunotherapy offers a new potential treatment paradigm with great promise. Immunotherapy of soft tissue sarcomas dates back to Dr. Coley's first use of toxins in the late 1800s. A variety of strategies of immunotherapy have been tried in soft tissue and bone sarcomas, including various vaccines and cytokines, with limited success...
September 21, 2017: Oncologist
https://www.readbyqxmd.com/read/28898984/analysis-of-daily-laboratory-orders-at-a-large-urban-academic-center-a-multifaceted-approach-to-changing-test-ordering-patterns
#8
Joseph W Rudolf, Anand S Dighe, Christopher M Coley, Irina K Kamis, Bradley M Wertheim, Douglas E Wright, Kent B Lewandrowski, Jason M Baron
Objectives: We sought to address concerns regarding recurring inpatient laboratory test order practices (daily laboratory tests) through a multifaceted approach to changing ordering patterns. Methods: We engaged in an interdepartmental collaboration to foster mindful test ordering through clinical policy creation, electronic clinical decision support, and continuous auditing and feedback. Results: Annualized daily order volumes decreased from approximately 25,000 to 10,000 during a 33-month postintervention review...
August 1, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28898245/improving-data-sharing-in-research-with-context-free-encoded-missing-data
#9
Marieke P Hoevenaar-Blom, Juliette Guillemont, Tiia Ngandu, Cathrien R L Beishuizen, Nicola Coley, Eric P Moll van Charante, Sandrine Andrieu, Miia Kivipelto, Hilkka Soininen, Carol Brayne, Yannick Meiller, Edo Richard
Lack of attention to missing data in research may result in biased results, loss of power and reduced generalizability. Registering reasons for missing values at the time of data collection, or-in the case of sharing existing data-before making data available to other teams, can save time and efforts, improve scientific value and help to prevent erroneous assumptions and biased results. To ensure that encoding of missing data is sufficient to understand the reason why data are missing, it should ideally be context-free...
2017: PloS One
https://www.readbyqxmd.com/read/28827317/coevolutionary-arms-race-versus-host-defense-chase-in-a-tropical-herbivore-plant-system
#10
María-José Endara, Phyllis D Coley, Gabrielle Ghabash, James A Nicholls, Kyle G Dexter, David A Donoso, Graham N Stone, R Toby Pennington, Thomas A Kursar
Coevolutionary models suggest that herbivores drive diversification and community composition in plants. For herbivores, many questions remain regarding how plant defenses shape host choice and community structure. We addressed these questions using the tree genus Inga and its lepidopteran herbivores in the Amazon. We constructed phylogenies for both plants and insects and quantified host associations and plant defenses. We found that similarity in herbivore assemblages between Inga species was correlated with similarity in defenses...
September 5, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28821540/investigating-undergraduate-students-use-of-intuitive-reasoning-and-evolutionary-knowledge-in-explanations-of-antibiotic-resistance
#11
Melissa Richard, John D Coley, Kimberly D Tanner
Natural selection is a central concept throughout biology; however, it is a process frequently misunderstood. Bacterial resistance to antibiotic medications provides a contextual example of the relevance of evolutionary theory and is also commonly misunderstood. While research has shed light on student misconceptions of natural selection, minimal study has focused on misconceptions of antibiotic resistance. Additionally, research has focused on the degree to which misconceptions may be based in the complexity of biological information or in pedagogical choices, rather than in deep-seated cognitive patterns...
2017: CBE Life Sciences Education
https://www.readbyqxmd.com/read/28744665/perceived-discrimination-and-health-related-quality-of-life-gender-differences-among-older-african-americans
#12
Sheryl L Coley, Carlos F Mendes de Leon, Earlise C Ward, Lisa L Barnes, Kimberly A Skarupski, Elizabeth A Jacobs
PURPOSE: Emerging data suggest that African-American women may fare worse than African-American men in health-related quality-of-life (HRQOL). Perceived discrimination is an important contributor to poor health overall among African Americans, but few studies examined the intersecting effects of perceived discrimination and gender in explaining HRQOL disparities. We investigated gender differences in HRQOL and tested whether perceived discrimination accounted for these differences. METHODS: We examined data from the Chicago Health and Aging Project in which 5652 African-American adults aged 65 and older completed structured questionnaires about demographic and socioeconomic characteristics, HRQOL, perceived discrimination, and health-related variables...
December 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28702505/human-snorna-93-is-processed-into-a-microrna-like-rna-that-promotes-breast-cancer-cell-invasion
#13
Dillon G Patterson, Justin T Roberts, Valeria M King, Dominika Houserova, Emmaline C Barnhill, Aline Crucello, Caroline J Polska, Lucas W Brantley, Garrett C Kaufman, Michael Nguyen, Megann W Santana, Ian A Schiller, Julius S Spicciani, Anastasia K Zapata, Molly M Miller, Timothy D Sherman, Ruixia Ma, Hongyou Zhao, Ritu Arora, Alexander B Coley, Melody M Zeidan, Ming Tan, Yaguang Xi, Glen M Borchert
Genetic searches for tumor suppressors have recently linked small nucleolar RNA misregulations with tumorigenesis. In addition to their classically defined functions, several small nucleolar RNAs are now known to be processed into short microRNA-like fragments called small nucleolar RNA-derived RNAs. To determine if any small nucleolar RNA-derived RNAs contribute to breast malignancy, we recently performed a RNA-seq-based comparison of the small nucleolar RNA-derived RNAs of two breast cancer cell lines (MCF-7 and MDA-MB-231) and identified small nucleolar RNA-derived RNAs derived from 13 small nucleolar RNAs overexpressed in MDA-MB-231s...
2017: NPJ Breast Cancer
https://www.readbyqxmd.com/read/28696688/convolutional-embedding-of-attributed-molecular-graphs-for-physical-property-prediction
#14
Connor W Coley, Regina Barzilay, William H Green, Tommi S Jaakkola, Klavs F Jensen
The task of learning an expressive molecular representation is central to developing quantitative structure-activity and property relationships. Traditional approaches rely on group additivity rules, empirical measurements or parameters, or generation of thousands of descriptors. In this paper, we employ a convolutional neural network for this embedding task by treating molecules as undirected graphs with attributed nodes and edges. Simple atom and bond attributes are used to construct atom-specific feature vectors that take into account the local chemical environment using different neighborhood radii...
August 28, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28688814/proceedings-beyond-ultrasound-first-forum-on-improving-the-quality-of-ultrasound-imaging-in-obstetrics-and-gynecology
#15
Beryl R Benacerraf, Katherine K Minton, Carol B Benson, Bryann S Bromley, Brian D Coley, Peter M Doubilet, Wesley Lee, Samuel H Maslak, John S Pellerito, James J Perez, Eric Savitsky, Norman A Scarborough, Joseph Wax, Alfred Z Abuhamad
The Beyond Ultrasound First Forum was conceived to increase awareness that the quality of obstetric and gynecologic ultrasound can be improved, and is inconsistent throughout the country, likely due to multiple factors, including the lack of a standardized curriculum and competency assessment in ultrasound teaching. The forum brought together representatives from many professional associations; the imaging community including radiology, obstetrics and gynecology, and emergency medicine among others; in addition to government agencies, insurers, industry, and others with common interest in obstetric and gynecologic ultrasound...
July 6, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28651035/material-efficient-microfluidic-platform-for-exploratory-studies-of-visible-light-photoredox-catalysis
#16
Connor W Coley, Milad Abolhasani, Hongkun Lin, Klavs F Jensen
We present an automated microfluidic platform for in-flow studies of visible-light photoredox catalysis in liquid or gas-liquid reactions at the 15 μL scale. An oscillatory flow strategy enables a flexible residence time while preserving the mixing and heat transfer advantages of flow systems. The adjustable photon flux made possible with the platform is characterized using actinometry. Case studies of oxidative hydroxylation of phenylboronic acids and dimerization of thiophenol demonstrate the capabilities and advantages of the system...
June 26, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28639883/cancer-immunotherapy-breakthrough-or-deja-vu-all-over-again
#17
REVIEW
Stewart Sell
From the application of Coley's toxin in the early 1900s to the present clinical trials using immune checkpoint regulatory inhibitors, the history of cancer immunotherapy has consisted of extremely high levels of enthusiasm after anecdotal case reports of enormous success, followed by decreasing levels of enthusiasm as the results of controlled clinical trials are available. In this review, this pattern will be documented for the various immunotherapeutic approaches over the years. The sole exception being vaccination against cancer causing viruses, which have already prevented thousands of cancers...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28598280/pathogens-and-glioma-a-history-of-unexpected-discoveries-ushering-in-novel-therapy
#18
Ashish H Shah, Ignacio Jusué-Torres, Michael E Ivan, Ricardo J Komotar, Noriyuki Kasahara
In the late 19th century, Dr. William B. Coley introduced the theory that infections may aid in the treatment of malignancy. With the creation of Coley's toxin, reports of remission during viral illnesses for systemic malignancies soon emerged. A few decades after this initial discovery, Austrian physicians performed intravascular injections of Clostridium to induce oncolysis in patients with glioblastoma. Since then, suggestions between improved survival and infectious processes have been reported in several patients with glioma, which ultimately marshaled the infamous use of intracerebral Enterobacter...
June 9, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28585652/a-segmented-flow-platform-for-on-demand-medicinal-chemistry-and-compound-synthesis-in-oscillating-droplets
#19
Ye-Jin Hwang, Connor W Coley, Milad Abolhasani, Andreas L Marzinzik, Guido Koch, Carsten Spanka, Hansjoerg Lehmann, Klavs F Jensen
We report an automated flow chemistry platform that can efficiently perform a wide range of chemistries, including single/multi-phase and single/multi-step, with a reaction volume of just 14 μL. The breadth of compatible chemistries is successfully demonstrated and the desired products are characterized, isolated, and collected online by preparative HPLC/MS/ELSD.
June 16, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28583042/cervical-cord-decompression-following-embolisation-of-a-giant-cervical-vertebro-vertebral-arteriovenous-fistula
#20
George H Tse, Umang J Patel, Stuart C Coley, Richard A Dyde
Arteriovenous fistulation between the vertebral arteries to extradural (epidural) veins, termed vertebro-vertebral arteriovenous fistulae, are uncommon diagnoses without established diagnostic algorithms or treatment options. Minimal evidence exists describing the management of this pathology. Endovascular treatment was performed under general anaesthesia by coil occlusion of the vertebral artery from the point of the fistula to the mid-vertebral artery. Repeat magnetic resonance angiographic imaging one week following the procedure confirmed an 80% reduction in the size of the epidural vein and decompression of the cervical spinal cord...
January 1, 2017: Interventional Neuroradiology
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