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https://www.readbyqxmd.com/read/28898984/analysis-of-daily-laboratory-orders-at-a-large-urban-academic-center-a-multifaceted-approach-to-changing-test-ordering-patterns
#1
Joseph W Rudolf, Anand S Dighe, Christopher M Coley, Irina K Kamis, Bradley M Wertheim, Douglas E Wright, Kent B Lewandrowski, Jason M Baron
Objectives: We sought to address concerns regarding recurring inpatient laboratory test order practices (daily laboratory tests) through a multifaceted approach to changing ordering patterns. Methods: We engaged in an interdepartmental collaboration to foster mindful test ordering through clinical policy creation, electronic clinical decision support, and continuous auditing and feedback. Results: Annualized daily order volumes decreased from approximately 25,000 to 10,000 during a 33-month postintervention review...
August 1, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28898245/improving-data-sharing-in-research-with-context-free-encoded-missing-data
#2
Marieke P Hoevenaar-Blom, Juliette Guillemont, Tiia Ngandu, Cathrien R L Beishuizen, Nicola Coley, Eric P Moll van Charante, Sandrine Andrieu, Miia Kivipelto, Hilkka Soininen, Carol Brayne, Yannick Meiller, Edo Richard
Lack of attention to missing data in research may result in biased results, loss of power and reduced generalizability. Registering reasons for missing values at the time of data collection, or-in the case of sharing existing data-before making data available to other teams, can save time and efforts, improve scientific value and help to prevent erroneous assumptions and biased results. To ensure that encoding of missing data is sufficient to understand the reason why data are missing, it should ideally be context-free...
2017: PloS One
https://www.readbyqxmd.com/read/28827317/coevolutionary-arms-race-versus-host-defense-chase-in-a-tropical-herbivore-plant-system
#3
María-José Endara, Phyllis D Coley, Gabrielle Ghabash, James A Nicholls, Kyle G Dexter, David A Donoso, Graham N Stone, R Toby Pennington, Thomas A Kursar
Coevolutionary models suggest that herbivores drive diversification and community composition in plants. For herbivores, many questions remain regarding how plant defenses shape host choice and community structure. We addressed these questions using the tree genus Inga and its lepidopteran herbivores in the Amazon. We constructed phylogenies for both plants and insects and quantified host associations and plant defenses. We found that similarity in herbivore assemblages between Inga species was correlated with similarity in defenses...
August 21, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28821540/investigating-undergraduate-students-use-of-intuitive-reasoning-and-evolutionary-knowledge-in-explanations-of-antibiotic-resistance
#4
Melissa Richard, John D Coley, Kimberly D Tanner
Natural selection is a central concept throughout biology; however, it is a process frequently misunderstood. Bacterial resistance to antibiotic medications provides a contextual example of the relevance of evolutionary theory and is also commonly misunderstood. While research has shed light on student misconceptions of natural selection, minimal study has focused on misconceptions of antibiotic resistance. Additionally, research has focused on the degree to which misconceptions may be based in the complexity of biological information or in pedagogical choices, rather than in deep-seated cognitive patterns...
2017: CBE Life Sciences Education
https://www.readbyqxmd.com/read/28744665/perceived-discrimination-and-health-related-quality-of-life-gender-differences-among-older-african-americans
#5
Sheryl L Coley, Carlos F Mendes de Leon, Earlise C Ward, Lisa L Barnes, Kimberly A Skarupski, Elizabeth A Jacobs
PURPOSE: Emerging data suggest that African-American women may fare worse than African-American men in health-related quality-of-life (HRQOL). Perceived discrimination is an important contributor to poor health overall among African Americans, but few studies examined the intersecting effects of perceived discrimination and gender in explaining HRQOL disparities. We investigated gender differences in HRQOL and tested whether perceived discrimination accounted for these differences. METHODS: We examined data from the Chicago Health and Aging Project in which 5652 African-American adults aged 65 and older completed structured questionnaires about demographic and socioeconomic characteristics, HRQOL, perceived discrimination, and health-related variables...
July 25, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28702505/human-snorna-93-is-processed-into-a-microrna-like-rna-that-promotes-breast-cancer-cell-invasion
#6
Dillon G Patterson, Justin T Roberts, Valeria M King, Dominika Houserova, Emmaline C Barnhill, Aline Crucello, Caroline J Polska, Lucas W Brantley, Garrett C Kaufman, Michael Nguyen, Megann W Santana, Ian A Schiller, Julius S Spicciani, Anastasia K Zapata, Molly M Miller, Timothy D Sherman, Ruixia Ma, Hongyou Zhao, Ritu Arora, Alexander B Coley, Melody M Zeidan, Ming Tan, Yaguang Xi, Glen M Borchert
Genetic searches for tumor suppressors have recently linked small nucleolar RNA misregulations with tumorigenesis. In addition to their classically defined functions, several small nucleolar RNAs are now known to be processed into short microRNA-like fragments called small nucleolar RNA-derived RNAs. To determine if any small nucleolar RNA-derived RNAs contribute to breast malignancy, we recently performed a RNA-seq-based comparison of the small nucleolar RNA-derived RNAs of two breast cancer cell lines (MCF-7 and MDA-MB-231) and identified small nucleolar RNA-derived RNAs derived from 13 small nucleolar RNAs overexpressed in MDA-MB-231s...
2017: NPJ Breast Cancer
https://www.readbyqxmd.com/read/28696688/convolutional-embedding-of-attributed-molecular-graphs-for-physical-property-prediction
#7
Connor W Coley, Regina Barzilay, William H Green, Tommi S Jaakkola, Klavs F Jensen
The task of learning an expressive molecular representation is central to developing quantitative structure-activity and property relationships. Traditional approaches rely on group additivity rules, empirical measurements or parameters, or generation of thousands of descriptors. In this paper, we employ a convolutional neural network for this embedding task by treating molecules as undirected graphs with attributed nodes and edges. Simple atom and bond attributes are used to construct atom-specific feature vectors that take into account the local chemical environment using different neighborhood radii...
July 25, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28688814/proceedings-beyond-ultrasound-first-forum-on-improving-the-quality-of-ultrasound-imaging-in-obstetrics-and-gynecology
#8
Beryl R Benacerraf, Katherine K Minton, Carol B Benson, Bryann S Bromley, Brian D Coley, Peter M Doubilet, Wesley Lee, Samuel H Maslak, John S Pellerito, James J Perez, Eric Savitsky, Norman A Scarborough, Joseph Wax, Alfred Z Abuhamad
The Beyond Ultrasound First Forum was conceived to increase awareness that the quality of obstetric and gynecologic ultrasound can be improved, and is inconsistent throughout the country, likely due to multiple factors, including the lack of a standardized curriculum and competency assessment in ultrasound teaching. The forum brought together representatives from many professional associations; the imaging community including radiology, obstetrics and gynecology, and emergency medicine among others; in addition to government agencies, insurers, industry, and others with common interest in obstetric and gynecologic ultrasound...
July 6, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28651035/material-efficient-microfluidic-platform-for-exploratory-studies-of-visible-light-photoredox-catalysis
#9
Connor W Coley, Milad Abolhasani, Hongkun Lin, Klavs F Jensen
We present an automated microfluidic platform for in-flow studies of visible-light photoredox catalysis in liquid or gas-liquid reactions at the 15 μL scale. An oscillatory flow strategy enables a flexible residence time while preserving the mixing and heat transfer advantages of flow systems. The adjustable photon flux made possible with the platform is characterized using actinometry. Case studies of oxidative hydroxylation of phenylboronic acids and dimerization of thiophenol demonstrate the capabilities and advantages of the system...
June 26, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28639883/cancer-immunotherapy-breakthrough-or-deja-vu-all-over-again
#10
REVIEW
Stewart Sell
From the application of Coley's toxin in the early 1900s to the present clinical trials using immune checkpoint regulatory inhibitors, the history of cancer immunotherapy has consisted of extremely high levels of enthusiasm after anecdotal case reports of enormous success, followed by decreasing levels of enthusiasm as the results of controlled clinical trials are available. In this review, this pattern will be documented for the various immunotherapeutic approaches over the years. The sole exception being vaccination against cancer causing viruses, which have already prevented thousands of cancers...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28598280/pathogens-and-glioma-a-history-of-unexpected-discoveries-ushering-in-novel-therapy
#11
Ashish H Shah, Ignacio Jusué-Torres, Michael E Ivan, Ricardo J Komotar, Noriyuki Kasahara
In the late 19th century, Dr. William B. Coley introduced the theory that infections may aid in the treatment of malignancy. With the creation of Coley's toxin, reports of remission during viral illnesses for systemic malignancies soon emerged. A few decades after this initial discovery, Austrian physicians performed intravascular injections of Clostridium to induce oncolysis in patients with glioblastoma. Since then, suggestions between improved survival and infectious processes have been reported in several patients with glioma, which ultimately marshaled the infamous use of intracerebral Enterobacter...
June 9, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28585652/a-segmented-flow-platform-for-on-demand-medicinal-chemistry-and-compound-synthesis-in-oscillating-droplets
#12
Ye-Jin Hwang, Connor W Coley, Milad Abolhasani, Andreas L Marzinzik, Guido Koch, Carsten Spanka, Hansjoerg Lehmann, Klavs F Jensen
We report an automated flow chemistry platform that can efficiently perform a wide range of chemistries, including single/multi-phase and single/multi-step, with a reaction volume of just 14 μL. The breadth of compatible chemistries is successfully demonstrated and the desired products are characterized, isolated, and collected online by preparative HPLC/MS/ELSD.
June 16, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28583042/cervical-cord-decompression-following-embolisation-of-a-giant-cervical-vertebro-vertebral-arteriovenous-fistula
#13
George H Tse, Umang J Patel, Stuart C Coley, Richard A Dyde
Arteriovenous fistulation between the vertebral arteries to extradural (epidural) veins, termed vertebro-vertebral arteriovenous fistulae, are uncommon diagnoses without established diagnostic algorithms or treatment options. Minimal evidence exists describing the management of this pathology. Endovascular treatment was performed under general anaesthesia by coil occlusion of the vertebral artery from the point of the fistula to the mid-vertebral artery. Repeat magnetic resonance angiographic imaging one week following the procedure confirmed an 80% reduction in the size of the epidural vein and decompression of the cervical spinal cord...
January 1, 2017: Interventional Neuroradiology
https://www.readbyqxmd.com/read/28573205/prediction-of-organic-reaction-outcomes-using-machine-learning
#14
Connor W Coley, Regina Barzilay, Tommi S Jaakkola, William H Green, Klavs F Jensen
Computer assistance in synthesis design has existed for over 40 years, yet retrosynthesis planning software has struggled to achieve widespread adoption. One critical challenge in developing high-quality pathway suggestions is that proposed reaction steps often fail when attempted in the laboratory, despite initially seeming viable. The true measure of success for any synthesis program is whether the predicted outcome matches what is observed experimentally. We report a model framework for anticipating reaction outcomes that combines the traditional use of reaction templates with the flexibility in pattern recognition afforded by neural networks...
May 24, 2017: ACS Central Science
https://www.readbyqxmd.com/read/28536768/quality-measures-and-pediatric-radiology-suggestions-for-the-transition-to-value-based-payment
#15
REVIEW
Richard E Heller, Brian D Coley, Stephen F Simoneaux, Daniel J Podberesky, Marta Hernanz-Schulman, Richard L Robertson, Lane F Donnelly
Recent political and economic factors have contributed to a meaningful change in the way that quality in health care, and by extension value, are viewed. While quality is often evaluated on the basis of subjective criteria, pay-for-performance programs that link reimbursement to various measures of quality require use of objective and quantifiable measures. This evolution to value-based payment was accelerated by the 2015 passage of the Medicare Access and CHIP (Children's Health Insurance Program) Reauthorization Act (MACRA)...
June 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28481420/anthropocentric-by-default-attribution-of-familiar-and-novel-properties-to-living-things
#16
Melanie Arenson, John D Coley
Humans naturally and effortlessly use a set of cognitive tools to reason about biological entities and phenomena. Two such tools, essentialist thinking and teleological thinking, appear to be early developmental cognitive defaults, used extensively in childhood and under limited circumstances in adulthood, but prone to reemerge under time pressure or cognitive load. We examine the nature of another such tool: anthropocentric thinking. In four experiments, we examined patterns of property attribution to a wide range of living and non-living objects, manipulating time pressure, response type, and property (either novel or familiar) in a total of 471 participants...
May 8, 2017: Cognitive Science
https://www.readbyqxmd.com/read/28478843/respiratory-alkalosis-may-impair-the-production-of-vitamin-d-and-lead-to-significant-morbidity-including-the-fibromyalgia-syndrome
#17
John M Lewis, Toinette H Fontrier, J Lynn Coley
Hyperventilation caused by physical and/or psychological stress may lead to significant respiratory alkalosis and an elevated systemic pH. The alkalotic pH may in turn suppress the normal renal release of phosphate into the urine, thereby interrupting the endogenous production of 1,25-dihydroxyvitamin D (calcitriol). This could cause a shortfall in its normal production, leading to a variety of adverse consequences. It might partially explain the pathogenesis of acute mountain sickness, a treatable disease characterized by severe hyperventilation secondary to the hypoxia of high altitude exposure...
May 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28473093/acr-appropriateness-criteria-%C3%A2-urinary-tract%C3%A2-infection-child
#18
Boaz K Karmazyn, Adina L Alazraki, Sudha A Anupindi, Molly E Dempsey, Jonathan R Dillman, Scott R Dorfman, Matthew D Garber, Sheila G Moore, Craig A Peters, Henry E Rice, Cynthia K Rigsby, Nabile M Safdar, Stephen F Simoneaux, Andrew T Trout, Sjirk J Westra, Sandra L Wootton-Gorges, Brian D Coley
Urinary tract infection (UTI) is common in young children and may cause pyelonephritis and renal scarring. Long-term complications from renal scarring are low. The role of imaging is to evaluate for underlying urologic abnormalities and guide treatment. In neonates there is increased risk for underlying urologic abnormalities. Evaluation for vesicoureteral reflux (VUR) may be appropriate especially in boys because of higher prevalence of VUR and to exclude posterior urethral valve. In children older than 2 months with first episode of uncomplicated UTI, there is no clear benefit of prophylactic antibiotic...
May 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28473069/acr-appropriateness-criteria-%C3%A2-back-pain-child
#19
Timothy N Booth, Ramesh S Iyer, Richard A Falcone, Laura L Hayes, Jeremy Y Jones, Nadja Kadom, Abhaya V Kulkarni, John S Myseros, Sonia Partap, Charles Reitman, Richard L Robertson, Maura E Ryan, Gaurav Saigal, Bruno P Soares, Aylin Tekes-Brady, Andrew T Trout, Nicholas A Zumberge, Brian D Coley, Susan Palasis
It is now generally accepted that nontraumatic back pain in the pediatric population is common. The presence of isolated back pain in a child has previously been an indication for imaging; however, recently a more conservative approach has been suggested using clinical criteria. The presence of constant pain, night pain, and radicular pain, alone or in combination, lasting for 4 weeks or more, constitute clinical red flags that should prompt further imaging. Without these clinical red flags, imaging is likely not indicated...
May 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28412301/environmental-risks-outweigh-dopaminergic-genetic-risks-for-alcohol-use-and-abuse-from-adolescence-through-early-adulthood
#20
Rebekah Levine Coley, Jacqueline Sims, Jennifer Carrano
BACKGROUND: Alcohol use is a primary public health concern, particularly among adolescents and young adults. Based on the rapidly growing field of gene-environment models, this study assessed the combined role of environmental and dopamine-related genetic correlates of early alcohol use and abuse. METHODS: Multilevel growth models assessed trajectories of alcohol use and intoxication and ordered logistic regressions assessed alcohol use disorder among a sample of 12,437 youth from the nationally representative Add Health study who were followed from mid-adolescence through early adulthood...
March 31, 2017: Drug and Alcohol Dependence
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