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John D Coley, Melanie Arenson, Yian Xu, Kimberly D Tanner
A large body of cognitive research has shown that people intuitively and effortlessly reason about the biological world in complex and systematic ways. We addressed two questions about the nature of intuitive biological reasoning: How does intuitive biological thinking change during adolescence and early adulthood? How does increasing biology education influence intuitive biological thinking? To do so, we developed a battery of measures to systematically test three components of intuitive biological thought: anthropocentric thinking, teleological thinking and essentialist thinking, and tested 8th graders and university students (both biology majors, and non-biology majors)...
November 16, 2016: Cognitive Psychology
W F Morano, A Aggarwal, P Love, S D Richard, J Esquivel, W B Bowne
Intraperitoneal immunotherapy represents a novel strategy for the management of peritoneal metastases (PM). Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) has remained the gold standard of treatment for patients with PM, yet despite optimal treatment, recurrence rates remain high and long-term survival poor. From Coley's toxins to immune checkpoint inhibitors, the wide variety of anticancer immunotherapeutic strategies are now garnering attention for control of regional disease of the peritoneal cavity...
November 2016: Cancer Gene Therapy
(no author information available yet)
No abstract text is available yet for this article.
October 2016: Cancer Immunology Research
Ryan J Bixenmann, Phyllis D Coley, Alexander Weinhold, Thomas A Kursar
Theoretical and empirical studies show that, when past or current herbivory is a reliable cue of future attack and defenses are costly, defenses can be induced only when needed and thereby permit investment in other functions such as growth or reproduction. Theory also states that, in environments where herbivory is constantly high, constitutive defenses should be favored. Here, we present data to support the second aspect of the induced resistance hypothesis. We examined herbivore-induced responses for four species of Inga (Fabaceae), a common canopy tree in Neotropical forests...
September 2016: Ecology and Evolution
David Falzon, R Peter Alston, Emma Coley, Katriona Montgomery
No abstract text is available yet for this article.
May 20, 2016: Journal of Cardiothoracic and Vascular Anesthesia
Rebecca Yates Coley, Aaron J Fisher, Mufaddal Mamawala, Herbert Ballentine Carter, Kenneth J Pienta, Scott L Zeger
In this article, we present a Bayesian hierarchical model for predicting a latent health state from longitudinal clinical measurements. Model development is motivated by the need to integrate multiple sources of data to improve clinical decisions about whether to remove or irradiate a patient's prostate cancer. Existing modeling approaches are extended to accommodate measurement error in cancer state determinations based on biopsied tissue, clinical measurements possibly not missing at random, and informative partial observation of the true state...
August 22, 2016: Biometrics
R Yates Coley, Scott L Zeger, Mufaddal Mamawala, Kenneth J Pienta, H Ballentine Carter
BACKGROUND: Active surveillance (AS) is an alternative to curative intervention, but overtreatment persists. Imperfect alignment of prostate biopsy and Gleason score after radical prostatectomy (RP) may be a contributing factor. OBJECTIVE: To develop a statistical model that predicts the post-RP Gleason score (pathologic Gleason score [PGS]) using clinical observations made in the course of AS. DESIGN, SETTING, AND PARTICIPANTS: Repeated prostate-specific antigen measurements and biopsy Gleason scores from 964 very low-risk patients in the Johns Hopkins Active Surveillance cohort were used in the analysis...
August 11, 2016: European Urology
Line Stensig Lynggaard, Hanne V Marquart, Eigil Kjeldsen, Hans O Madsen, Henrik Hasle
A small group of children with acute lymphoblastic leukemia (ALL) have a preleukemic phase of pancytopenia followed by a period of spontaneous remission before the diagnosis (pre-ALL). A 6-year-old girl presented with pancytopenia, fever, and myelodysplasia. Following transient remission pre-B ALL was diagnosed 14 months later. Clonal B-lineage blasts at the period of pancytopenia were identified retrospectively. The interval between pre-ALL and ALL-diagnosis was longer than previously reported. The infection was clinically severe and might have induced a significant endogenous corticosteroids production resulting in the long-lasting remission...
November 2016: Journal of Pediatric Hematology/oncology
S Samji, H Y Small, S Coley, H Mischak, W Mullen, C Delles
OBJECTIVE: Stroke-prone spontaneously hypertensive rats (SHRSP) are a model of chronic hypertension relative to normotensive Wistar-Kyoto rats (WKY). Our studies on urinary protein and electrolyte levels have shown kidney dysfunction and impaired water balance in pregnant SHRSP. We investigated whether urinary peptidomics can identify target molecules involved in kidney dysfunction in pregnant SHRSP. DESIGN AND METHOD: We analyzed urine of non-pregnant and pregnant WKY and SHRSP (n = 7) at 0th, 12th and 18th gestational day (GD) using capillary electrophoresis on-line coupled to ESI-TOF-MS...
September 2016: Journal of Hypertension
Devon H Ghodasra, Adrienne Chen, J Fernando Arevalo, David G Birch, Kari Branham, Brian Coley, Gislin Dagnelie, Eugene de Juan, Robert G Devenyi, Jessy D Dorn, Andy Fisher, Duane R Geruschat, Ninel Z Gregori, Robert J Greenberg, Paul Hahn, Allen C Ho, Ashley Howson, Suber S Huang, Raymond Iezzi, Naheed Khan, Byron L Lam, Jennifer I Lim, Kirsten G Locke, Michelle Markowitz, Anne-Marie Ripley, Mark Rankin, Hannah Schimitzek, Fay Tripp, James D Weiland, Jiong Yan, David N Zacks, K Thiran Jayasundera
No abstract text is available yet for this article.
2016: BMC Ophthalmology
Nicola Coley, Adeline Gallini, Pierre-Jean Ousset, Bruno Vellas, Sandrine Andrieu
INTRODUCTION: Composite cognitive scores have been developed as primary outcome measures for preclinical/prevention trials for Alzheimer's disease (AD), mainly using observational data and with little consideration of clinical relevance. METHODS: Secondary analysis of placebo group data from a 5-year AD prevention trial. The composite score was the average of the following z scores: MMSE orientation items, Free and Cued Selective Reminding Test, Category Fluency, Trail Making Test-part B...
December 2016: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
Sjirk J Westra, Boaz K Karmazyn, Adina L Alazraki, Molly E Dempsey, Jonathan R Dillman, Matthew Garber, Sheila G Moore, Molly E Raske, Henry E Rice, Cynthia K Rigsby, Nabile Safdar, Stephen F Simoneaux, Peter J Strouse, Andrew T Trout, Sandra L Wootton-Gorges, Brian D Coley
The cause of fever in a child can often be determined from history, physical examination, and laboratory tests; infections account for the majority of cases. Yet in 20%, no apparent cause can be found, designated as fever without source (FWS). The yield of chest radiography in children with FWS is low, and it is usually not appropriate. However, in children with respiratory signs, high fever (>39°C), or marked leukocytosis (≥20,000/mm(3)), chest radiography is usually appropriate, as it has a higher yield in detecting clinically occult pneumonia...
August 2016: Journal of the American College of Radiology: JACR
Caitlin McPherran Lombardi, Rebekah Levine Coley
This study assessed the links between early maternal employment and children's later academic and behavioral skills in Australia and the United Kingdom. Using representative samples of children born in each country from 2000 to 2004 (Australia N = 5,093, U.K. N = 18,497), OLS regression models weighted with propensity scores assessed links between maternal employment in the 2 years after childbearing and children's skills in first grade. There were neutral associations between maternal employment and children's first-grade skills in both countries...
July 1, 2016: Child Development
Reed D Gurchiek, Coley T Pritchett, Herman van Werkhoven
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
Lilliam Ambroggio, Heidi Sucharew, Mantosh S Rattan, Sara M O'Hara, Diane S Babcock, Caitlin Clohessy, Mark C Steinhoff, Maurizio Macaluso, Samir S Shah, Brian D Coley
OBJECTIVE: To determine the interrater reliability (IRR) of lung ultrasonography (LUS) and chest radiography (CXR) and evaluate the accuracy of LUS compared with CXR for detecting pediatric pneumonia compared with chest computed tomography (CT) scan. STUDY DESIGN: This was a prospective cohort study of children aged 3 months to 18 years with a CXR and LUS performed between May 1, 2012, and January 31, 2014 with or without a clinical diagnosis of pneumonia. Four pediatric radiologists blinded to clinical information reported findings for the CXR and LUS images...
September 2016: Journal of Pediatrics
Pallab K Sarker, Anne R Kapuscinski, Alison J Lanois, Erin D Livesey, Katie P Bernhard, Mariah L Coley
We conducted a 84-day nutritional feeding experiment with dried whole cells of DHA-rich marine microalga Schizochytrium sp. (Sc) to determine the optimum level of fish-oil substitution (partial or complete) for maximum growth of Nile tilapia. When we fully replaced fish oil with Schizochytrium (Sc100 diet), we found significantly higher weight gain and protein efficiency ratio (PER), and lower (improved) feed conversion ratio (FCR) and feed intake compared to a control diet containing fish oil (Sc0); and no significant change in SGR and survival rate among all diets...
2016: PloS One
Brooke M Augustin-Coley, David C Pigott, C Blayke Gibson, Ross M Vander Noot, John P Gullett
No abstract text is available yet for this article.
June 2016: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
Rebekah Levine Coley, Melissa Kull
Residential mobility has received notable attention in the literature, yet there remains limited consensus on how and when mobility is associated with detriments to children's development. Drawing on a nationally representative sample of 19,162 children in the Early Childhood Longitudinal Study followed from kindergarten through eighth grade, this study compared cumulative, timing-specific, and interactive models of mobility. Results found that mobility during middle childhood and early adolescence was negatively associated with children's cognitive skills, with short-term effects that dissipated over time...
July 2016: Child Development
Maurice Orange, Uwe Reuter, Uwe Hobohm
The following four observations point in the same direction, namely that there is an unleveraged potential for stimulating the innate immune system against cancer: (1) experimental treatments with bacterial extracts more than 100 years ago by Coley and contemporaries, (2) a positive correlation between spontaneous regressions and febrile infection, (3) epidemiological data suggesting an inverse correlation between a history of infection and the likelihood of developing cancer, and (4) our recent finding that a cocktail of pattern recognition receptor ligands (PRRLs) can eradicate solid tumors in cancer mice if applied metronomically...
May 20, 2016: Integrative Cancer Therapies
Devon H Ghodasra, Adrienne Chen, J Fernando Arevalo, David G Birch, Kari Branham, Brian Coley, Gislin Dagnelie, Eugene de Juan, Robert G Devenyi, Jessy D Dorn, Andy Fisher, Duane R Geruschat, Ninel Z Gregori, Robert J Greenberg, Paul Hahn, Allen C Ho, Ashley Howson, Suber S Huang, Raymond Iezzi, Naheed Khan, Byron L Lam, Jennifer I Lim, Kirsten G Locke, Michelle Markowitz, Anne-Marie Ripley, Mark Rankin, Hannah Schimitzek, Fay Tripp, James D Weiland, Jiong Yan, David N Zacks, K Thiran Jayasundera
BACKGROUND: A position paper based on the collective experiences of Argus II Retinal Prosthesis System investigators to review strategies to optimize outcomes in patients with retinitis pigmentosa undergoing retinal prosthesis implantation. METHODS: Retinal surgeons, device programmers, and rehabilitation specialists from Europe, Canada, Middle East, and the United States were convened to the first international Argus II Investigator Meeting held in Ann Arbor, MI in March 2015...
May 6, 2016: BMC Ophthalmology
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