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Kyle G Dexter, Mathew Lavin, Benjamin M Torke, Alex D Twyford, Thomas A Kursar, Phyllis D Coley, Camila Drake, Ruth Hollands, R Toby Pennington
We investigate patterns of historical assembly of tree communities across Amazonia using a newly developed phylogeny for the species-rich neotropical tree genus Inga We compare our results with those for three other ecologically important, diverse, and abundant Amazonian tree lineages, Swartzia, Protieae, and Guatteria Our analyses using phylogenetic diversity metrics demonstrate a clear lack of geographic phylogenetic structure, and show that local communities of Inga and regional communities of all four lineages are assembled by dispersal across Amazonia...
February 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
Gábor Nagy, Alison Grainger, Timothy J Hodgson, Jeremy G Rowe, Stuart C Coley, Andras A Kemeny, Matthias W R Radatz
No abstract text is available yet for this article.
February 1, 2017: Neurosurgery
Rasheeta Chandler-Coley, Henry Ross, Oluwatobi Ozoya, Celia Lescano, Timothy Flannigan
Media messages can facilitate the delivery of accurate information related to HIV and sexually transmitted infection. This study's purpose was to examine preexisting media campaigns from the iMPPACS study to assess age-, gender-, and culturally appropriate components identified by African American females who attend historically Black colleges/universities. In 3 separate focus group sessions, 31 Black female college students (M age = 20) viewed 4 vignettes and heard 3 audio-only clips, then ranked and commented on them based on perceived satisfaction with HIV prevention content and appropriateness of delivery...
January 18, 2017: Journal of Health Communication
J Melissa Hernandez-Moreno, Nicole M Bayeur, Harold D Coley, Nicole M Hughes
Multiple studies have examined the effects of clouds on shoot and canopy-level microclimate and physiological processes; none have yet done so on the scale of individual plant crowns. We compared incident photosynthetically active radiation (PAR), leaf temperatures, chlorophyll fluorescence, and photosynthetic gas exchange of shoots in three different spatial locations of Abies fraseri crowns on sunny (clear to partly cloudy) versus overcast days. The field site was a Fraser fir farm (1038 m elevation) in the Appalachian mountains, USA...
January 10, 2017: Oecologia
Wolf Hervé Fridman
HISTORY OF IMMUNOTHERAPY. PARADIGM CHANGE?: Born at the dawn of the 20th century with W.B. Coley's intratumoral injections of bacteria, cancer immunotherapy was built on the corpus of the immune surveillance theory in 1957, modified by R.D. Schreiber in 2004. Scientific knowledge and technological advances have allowed it to become efficacious and to expand in the 21st century as the 4th and most important pillar of cancer treatment.
November 2016: Bulletin du Cancer
Gabriele D'Errico, Heather L Machado, Bruno Sainz
Immunotherapy is the new trend in cancer treatment due to the selectivity, long lasting effects, and demonstrated improved overall survival and tolerance, when compared to patients treated with conventional chemotherapy. Despite these positive results, immunotherapy is still far from becoming the perfect magic bullet to fight cancer, largely due to the facts that immunotherapy is not effective in all patients nor in all cancer types. How and when will immunotherapy overcome these hurdles? In this review we take a step back to walk side by side with the pioneers of immunotherapy in order to understand what steps need to be taken today to make immunotherapy effective across all cancers...
December 2017: Clinical and Translational Medicine
C Lopez, N Nagornaya, N Parra, D Kwon, F Ishkanian, A Markoe, A Maudsley, R Stoyanova
PURPOSE: High-throughput extraction of imaging and metabolomic quantitative features from MRI and MR Spectroscopy Imaging (MRSI) of Glioblastoma Multiforme (GBM) results in tens of variables per patient. In radiotherapy (RT) of GBM, the relevant metabolic tumor volumes (MTVs) are related to aberrant levels of N-acetyl Aspartate (NAA) and Choline (Cho). Corresponding Clinical Target Volumes (CTVs) for RT planning are based on Contrast Enhancing T1-weighted MRI (CE-T1w) and T2-weighted/Fluid Attenuated Inversion Recovery (FLAIR) MRI...
June 2016: Medical Physics
Isa N Cruz, Helen M Coley, Holger B Kramer, Thumuluru Kavitah Madhuri, Nur A M Safuwan, Ana Rita Angelino, Min Yang
BACKGROUND: Carboplatin and paclitaxel form the cornerstone of chemotherapy for epithelial ovarian cancer, however, drug resistance to these agents continues to present challenges. Despite extensive research, the mechanisms underlying this resistance remain unclear. MATERIALS AND METHODS: A 2D-gel proteomics method was used to analyze protein expression levels of three human ovarian cancer cell lines and five biopsy samples. Representative proteins identified were validated via western immunoblotting...
2, 2017: Cancer Genomics & Proteomics
Ishwariya Venkatesh, Matthew T Simpson, Denise M Coley, Murray G Blackmore
Axon regeneration in adult central nervous system (CNS) is limited in part by a developmental decline in the ability of injured neurons to re-express needed regeneration associated genes (RAGs). Adult CNS neurons may lack appropriate pro-regenerative transcription factors, or may display chromatin structure that restricts transcriptional access to RAGs. Here we performed epigenetic profiling around the promoter regions of key RAGs, and found progressive restriction across a time course of cortical maturation...
December 2016: Neuroepigenetics
John D Coley, Melanie Arenson, Yian Xu, Kimberly D Tanner
A large body of cognitive research has shown that people intuitively and effortlessly reason about the biological world in complex and systematic ways. We addressed two questions about the nature of intuitive biological reasoning: How does intuitive biological thinking change during adolescence and early adulthood? How does increasing biology education influence intuitive biological thinking? To do so, we developed a battery of measures to systematically test three components of intuitive biological thought: anthropocentric thinking, teleological thinking and essentialist thinking, and tested 8th graders and university students (both biology majors, and non-biology majors)...
February 2017: Cognitive Psychology
W F Morano, A Aggarwal, P Love, S D Richard, J Esquivel, W B Bowne
Intraperitoneal immunotherapy represents a novel strategy for the management of peritoneal metastases (PM). Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) has remained the gold standard of treatment for patients with PM, yet despite optimal treatment, recurrence rates remain high and long-term survival poor. From Coley's toxins to immune checkpoint inhibitors, the wide variety of anticancer immunotherapeutic strategies are now garnering attention for control of regional disease of the peritoneal cavity...
November 2016: Cancer Gene Therapy
(no author information available yet)
No abstract text is available yet for this article.
October 2016: Cancer Immunology Research
Ryan J Bixenmann, Phyllis D Coley, Alexander Weinhold, Thomas A Kursar
Theoretical and empirical studies show that, when past or current herbivory is a reliable cue of future attack and defenses are costly, defenses can be induced only when needed and thereby permit investment in other functions such as growth or reproduction. Theory also states that, in environments where herbivory is constantly high, constitutive defenses should be favored. Here, we present data to support the second aspect of the induced resistance hypothesis. We examined herbivore-induced responses for four species of Inga (Fabaceae), a common canopy tree in Neotropical forests...
September 2016: Ecology and Evolution
David Falzon, R Peter Alston, Emma Coley, Katriona Montgomery
No abstract text is available yet for this article.
May 20, 2016: Journal of Cardiothoracic and Vascular Anesthesia
Rebecca Yates Coley, Aaron J Fisher, Mufaddal Mamawala, Herbert Ballentine Carter, Kenneth J Pienta, Scott L Zeger
In this article, we present a Bayesian hierarchical model for predicting a latent health state from longitudinal clinical measurements. Model development is motivated by the need to integrate multiple sources of data to improve clinical decisions about whether to remove or irradiate a patient's prostate cancer. Existing modeling approaches are extended to accommodate measurement error in cancer state determinations based on biopsied tissue, clinical measurements possibly not missing at random, and informative partial observation of the true state...
August 22, 2016: Biometrics
R Yates Coley, Scott L Zeger, Mufaddal Mamawala, Kenneth J Pienta, H Ballentine Carter
BACKGROUND: Active surveillance (AS) is an alternative to curative intervention, but overtreatment persists. Imperfect alignment of prostate biopsy and Gleason score after radical prostatectomy (RP) may be a contributing factor. OBJECTIVE: To develop a statistical model that predicts the post-RP Gleason score (pathologic Gleason score [PGS]) using clinical observations made in the course of AS. DESIGN, SETTING, AND PARTICIPANTS: Repeated prostate-specific antigen measurements and biopsy Gleason scores from 964 very low-risk patients in the Johns Hopkins Active Surveillance cohort were used in the analysis...
August 11, 2016: European Urology
Line Stensig Lynggaard, Hanne V Marquart, Eigil Kjeldsen, Hans O Madsen, Henrik Hasle
A small group of children with acute lymphoblastic leukemia (ALL) have a preleukemic phase of pancytopenia followed by a period of spontaneous remission before the diagnosis (pre-ALL). A 6-year-old girl presented with pancytopenia, fever, and myelodysplasia. Following transient remission pre-B ALL was diagnosed 14 months later. Clonal B-lineage blasts at the period of pancytopenia were identified retrospectively. The interval between pre-ALL and ALL-diagnosis was longer than previously reported. The infection was clinically severe and might have induced a significant endogenous corticosteroids production resulting in the long-lasting remission...
November 2016: Journal of Pediatric Hematology/oncology
S Samji, H Y Small, S Coley, H Mischak, W Mullen, C Delles
OBJECTIVE: Stroke-prone spontaneously hypertensive rats (SHRSP) are a model of chronic hypertension relative to normotensive Wistar-Kyoto rats (WKY). Our studies on urinary protein and electrolyte levels have shown kidney dysfunction and impaired water balance in pregnant SHRSP. We investigated whether urinary peptidomics can identify target molecules involved in kidney dysfunction in pregnant SHRSP. DESIGN AND METHOD: We analyzed urine of non-pregnant and pregnant WKY and SHRSP (n = 7) at 0th, 12th and 18th gestational day (GD) using capillary electrophoresis on-line coupled to ESI-TOF-MS...
September 2016: Journal of Hypertension
Devon H Ghodasra, Adrienne Chen, J Fernando Arevalo, David G Birch, Kari Branham, Brian Coley, Gislin Dagnelie, Eugene de Juan, Robert G Devenyi, Jessy D Dorn, Andy Fisher, Duane R Geruschat, Ninel Z Gregori, Robert J Greenberg, Paul Hahn, Allen C Ho, Ashley Howson, Suber S Huang, Raymond Iezzi, Naheed Khan, Byron L Lam, Jennifer I Lim, Kirsten G Locke, Michelle Markowitz, Anne-Marie Ripley, Mark Rankin, Hannah Schimitzek, Fay Tripp, James D Weiland, Jiong Yan, David N Zacks, K Thiran Jayasundera
No abstract text is available yet for this article.
2016: BMC Ophthalmology
Nicola Coley, Adeline Gallini, Pierre-Jean Ousset, Bruno Vellas, Sandrine Andrieu
INTRODUCTION: Composite cognitive scores have been developed as primary outcome measures for preclinical/prevention trials for Alzheimer's disease (AD), mainly using observational data and with little consideration of clinical relevance. METHODS: Secondary analysis of placebo group data from a 5-year AD prevention trial. The composite score was the average of the following z scores: MMSE orientation items, Free and Cued Selective Reminding Test, Category Fluency, Trail Making Test-part B...
December 2016: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
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