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https://www.readbyqxmd.com/read/29306183/child-maltreatment-re-offending-in-families-served-by-the-united-states-air-force-family-advocacy-program
#1
Randy J McCarthy, Joel S Milner, Sarah L Coley, LaJuana Ormsby, Mark Oliver
The current study examined child maltreatment re-offending in United States Air Force (USAF) families. In a clinical database containing 24,999 child maltreatment incidents perpetrated by 15,042 offenders between the years 1997 and 2013, 13% of offenders maltreated a child on more than one date (i.e., they re-offended). We explored several offender demographic characteristics associated with who re-offended and found that civilians re-offended at a similar rate as active duty members, males re-offended at a similar rate as females, and younger offenders were more likely to re-offend than older offenders...
January 3, 2018: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29297609/proceedings-beyond-ultrasound-first-forum-on-improving-the-quality-of-ultrasound-imaging-in-obstetrics-and-gynecology
#2
Beryl R Benacerraf, Katherine K Minton, Carol B Benson, Bryann S Bromley, Brian D Coley, Peter M Doubilet, Wesley Lee, Samuel H Maslak, John S Pellerito, James J Perez, Eric Savitsky, Norman A Scarborough, Joseph Wax, Alfred Z Abuhamad
The Beyond Ultrasound First Forum was conceived to increase awareness that the quality of obstetric and gynecologic ultrasound can be improved, and is inconsistent throughout the country, likely due to multiple factors, including the lack of a standardized curriculum and competency assessment in ultrasound teaching. The forum brought together representatives from many professional associations; the imaging community including radiology, obstetrics and gynecology, and emergency medicine among others; in addition to government agencies, insurers, industry, and others with common interest in obstetric and gynecologic ultrasound...
January 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29296663/computer-assisted-retrosynthesis-based-on-molecular-similarity
#3
Connor W Coley, Luke Rogers, William H Green, Klavs F Jensen
We demonstrate molecular similarity to be a surprisingly effective metric for proposing and ranking one-step retrosynthetic disconnections based on analogy to precedent reactions. The developed approach mimics the retrosynthetic strategy defined implicitly by a corpus of known reactions without the need to encode any chemical knowledge. Using 40 000 reactions from the patent literature as a knowledge base, the recorded reactants are among the top 10 proposed precursors in 74.1% of 5000 test reactions, providing strong quantitative support for our methodology...
December 27, 2017: ACS Central Science
https://www.readbyqxmd.com/read/29208590/the-national-patient-centered-clinical-research-network-pcornet-bariatric-study-cohort-rationale-methods-and-baseline-characteristics
#4
Sengwee Toh, Laura J Rasmussen-Torvik, Emily E Harmata, Roy Pardee, Rosalinde Saizan, Elisha Malanga, Jessica L Sturtevant, Casie E Horgan, Jane Anau, Cheri D Janning, Robert D Wellman, R Yates Coley, Andrea J Cook, Anita P Courcoulas, Karen J Coleman, Neely A Williams, Kathleen M McTigue, David Arterburn, James McClay
BACKGROUND: Although bariatric procedures are commonly performed in clinical practice, long-term data on the comparative effectiveness and safety of different procedures on sustained weight loss, comorbidities, and adverse effects are limited, especially in important patient subgroups (eg, individuals with diabetes, older patients, adolescents, and minority patients). OBJECTIVE: The objective of this study was to create a population-based cohort of patients who underwent 3 commonly performed bariatric procedures-adjustable gastric band (AGB), Roux-en-Y gastric bypass (RYGB), and sleeve gastrectomy (SG)-to examine the long-term comparative effectiveness and safety of these procedures in both adults and adolescents...
December 5, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/29208354/more-than-a-number-perspectives-of-prenatal-care-quality-from-mothers-of-color-and-providers
#5
Sheryl L Coley, Jasmine Y Zapata, Rebecca J Schwei, Glen Ellen Mihalovic, Maya N Matabele, Elizabeth A Jacobs, Cynthie K Anderson
INTRODUCTION: African American mothers and other mothers of historically underserved populations consistently have higher rates of adverse birth outcomes than White mothers. Increasing prenatal care use among these mothers may reduce these disparities. Most prenatal care research focuses on prenatal care adequacy rather than concepts of quality. Even less research examines the dual perspectives of African American mothers and prenatal care providers. In this qualitative study, we compared perceptions of prenatal care quality between African American and mixed race mothers and prenatal care providers...
December 2, 2017: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/29188863/cross-sectional-associations-of-total-plasma-homocysteine-with-cortical-%C3%AE-amyloid-independently-and-as-a-function-of-omega-3-polyunsaturated-fatty-acid-status-in-older-adults-at-risk-of-dementia
#6
C Hooper, P De Souto Barreto, N Coley, E Caussé, P Payoux, A S Salabert, M Cesari, S Andrieu, G-L Bowman, M Weiner, B Vellas
OBJECTIVES: Elevated total plasma homocysteine is a risk factor for Alzheimer's disease (AD) and there is some evidence that omega-3 polyunsaturated fatty acids (n-3 PUFAs) can modulate the effects of homocysteine-lowering B vitamins on AD related pathologies. Hence we investigated the relationship between total plasma homocysteine and cortical β-amyloid (Aβ) in older adults at risk of dementia. The role of erythrocyte membrane n-3 PUFAs (omega 3 index) on this relationship was also explored...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29169997/psd95-a-synaptic-protein-implicated-in-schizophrenia-or-autism
#7
REVIEW
Austin A Coley, Wen-Jun Gao
The molecular components of the postsynaptic density (PSD) in excitatory synapses of the brain are currently being investigated as one of the major etiologies of neurodevelopmental disorders such as schizophrenia (SCZ) and autism. Postsynaptic density protein-95 (PSD-95) is a major regulator of synaptic maturation by interacting, stabilizing and trafficking N-methyl-d-aspartic acid receptors (NMDARs) and α-amino-3-hydroxy-5-methyl-4-isox-azoleproprionic acid receptors (AMPARs) to the postsynaptic membrane...
November 20, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29164115/cross-sectional-associations-of-fatigue-with-cerebral-%C3%AE-amyloid-in-older-adults-at-risk-of-dementia
#8
Claudie Hooper, Philipe De Souto Barreto, Nicola Coley, Matteo Cesari, Pierre Payoux, Anne Sophie Salabert, Sandrine Andrieu, Bruno Vellas
Fatigue is a common symptom in the elderly and has also been associated with impaired cognition in older adults. Hence, we sought to explore the cross-sectional relationship between fatigue and cerebral β-amyloid (Aβ) in 269 elderly individuals reporting subjective memory complaints from the Multidomain Alzheimer Preventive Trial. Standard uptake value ratios (SUVRs) were generated by [(18)F] florbetapir positron emission tomography (PET) using the cerebellum as a reference. Cortical-to-cerebellar SUVRs (cortical-SUVRs) were obtained using the mean signal from the frontal cortex, temporal cortex, parietal cortex, precuneus, anterior cingulate, and posterior cingulate...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/29093013/2017-william-b-coley-award
#9
(no author information available yet)
No abstract text is available yet for this article.
November 2017: Cancer Immunology Research
https://www.readbyqxmd.com/read/29083439/cognitive-changes-with-omega-3-polyunsaturated-fatty-acids-in-non-demented-older-adults-with-low-omega-3-index
#10
C Hooper, P De Souto Barreto, N Coley, C Cantet, M Cesari, S Andrieu, B Vellas
OBJECTIVES: To investigate the changes in specific domains of cognitive function in older adults reporting subjective memory complaints with a low omega-3 index receiving omega 3 polyunsaturated fatty acid (n-3 PUFA) supplementation or placebo. DESIGN: This is a secondary exploratory analysis of the Multidomain Alzheimer Preventive Trial (MAPT) using subjects randomized to the n-3 PUFA supplementation or placebo group. SETTING: French community dwellers aged 70 or over reporting subjective memory complaints, but free from clinical dementia...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29073335/in-situ-microfluidic-studies-of-bi-phasic-nanocrystal-ligand-exchange-reaction-using-oscillatory-flow-reactor
#11
Yi Shen, Milad Abolhasani, Yue Chen, Lisi Xie, Lu Yang, Connor Coley, Moungi Bawendi, Klavs F Jensen
Oscillatory flow reactors provide a surface energy-driven approach for automatically screening reaction conditions and studying reaction mechanisms of bi-phasic nanocrystal ligand exchange reactions. Sulfide and cysteine ligand exchange reactions with as-synthesized CdSe quantum dots (QDs) are chosen as two model reactions. Different reaction variables including the new-ligand-to-QD ratio, the size of the particles, and the original ligand type are examined systematically. Based on the in-situ obtained UV-Vis absorption spectra during the reaction, we propose two different exchange pathways for the sulfide exchange reaction...
October 26, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29063081/automated-microfluidic-platform-for-systematic-studies-of-colloidal-perovskite-nanocrystals-towards-continuous-nano-manufacturing
#12
Robert W Epps, Kobi C Felton, Connor W Coley, Milad Abolhasani
Colloidal organic/inorganic metal-halide perovskite nanocrystals have recently emerged as a potential low-cost replacement for the semiconductor materials in commercial photovoltaics and light emitting diodes. However, unlike III-V and IV-VI semiconductor nanocrystals, studies of colloidal perovskite nanocrystals have yet to develop a fundamental and comprehensive understanding of nucleation and growth kinetics. Here, we introduce a modular and automated microfluidic platform for the systematic studies of room-temperature synthesized cesium-lead halide perovskite nanocrystals...
November 21, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/29034781/point-of-care-testing-in-community-pharmacies-keys-to-success-from-pennsylvania-pharmacists
#13
Emily A Steltenpohl, Brandon K Barry, Kim C Coley, Melissa S McGivney, Julie L Olenak, Lucas A Berenbrok
BACKGROUND: Clinical Laboratory Improvement Amendments (CLIA)-waived tests allow for quick, accurate, and noninvasive laboratory testing. Community pharmacists utilize CLIA-waived tests to provide clinical services such as point-of-care (POC) testing to help manage chronic disease and acute illness. OBJECTIVE: To identify key themes in the successful delivery of POC testing services by community pharmacists in Pennsylvania. RESULTS: An initial search identified 51 Pennsylvania pharmacies with a CLIA waiver...
January 1, 2017: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28956916/driving-force-dependence-of-electron-transfer-from-electronically-excited-ir-cod-%C3%AE-me2pz-2-to-photo-acid-generators
#14
Wesley Sattler, Aaron A Rachford, Paul J LaBeaume, Suzanne M Coley, James W Thackeray, James F Cameron, Astrid M Müller, Jay R Winkler, Harry B Gray
We report the rates of electron transfer (ET) reactions of electronically excited [Ir(COD)(μ-Me2pz)]2 with onium salt photoacid generators (PAGs). The reduction potentials of the PAGs span a large electrochemical window that allows determination of the driving force dependence of the ET reactions. Rate constants of ET from electronically excited [Ir(COD)(μ-Me2pz)]2 to onium PAGs are determined by the reaction driving force until the diffusion limit in acetonitrile is reached.
September 28, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28935774/immunotherapy-a-new-and-old-approach-to-treatment-of-soft-tissue-and-bone-sarcomas
#15
REVIEW
Michael J Nathenson, Anthony P Conley, Edward Sausville
Soft tissue and bone sarcomas are a rare and heterogeneous form of cancer. With standard of care treatment options including surgery, radiation, and chemotherapy, the long-term survival is still low for high-risk soft tissue sarcoma patients. New treatment strategies are needed. Immunotherapy offers a new potential treatment paradigm with great promise. Immunotherapy of soft tissue sarcomas dates back to Dr. Coley's first use of toxins in the late 1800s. A variety of strategies of immunotherapy have been tried in soft tissue and bone sarcomas, including various vaccines and cytokines, with limited success...
September 21, 2017: Oncologist
https://www.readbyqxmd.com/read/28898984/analysis-of-daily-laboratory-orders-at-a-large-urban-academic-center-a-multifaceted-approach-to-changing-test-ordering-patterns
#16
Joseph W Rudolf, Anand S Dighe, Christopher M Coley, Irina K Kamis, Bradley M Wertheim, Douglas E Wright, Kent B Lewandrowski, Jason M Baron
Objectives: We sought to address concerns regarding recurring inpatient laboratory test order practices (daily laboratory tests) through a multifaceted approach to changing ordering patterns. Methods: We engaged in an interdepartmental collaboration to foster mindful test ordering through clinical policy creation, electronic clinical decision support, and continuous auditing and feedback. Results: Annualized daily order volumes decreased from approximately 25,000 to 10,000 during a 33-month postintervention review...
August 1, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28898245/improving-data-sharing-in-research-with-context-free-encoded-missing-data
#17
Marieke P Hoevenaar-Blom, Juliette Guillemont, Tiia Ngandu, Cathrien R L Beishuizen, Nicola Coley, Eric P Moll van Charante, Sandrine Andrieu, Miia Kivipelto, Hilkka Soininen, Carol Brayne, Yannick Meiller, Edo Richard
Lack of attention to missing data in research may result in biased results, loss of power and reduced generalizability. Registering reasons for missing values at the time of data collection, or-in the case of sharing existing data-before making data available to other teams, can save time and efforts, improve scientific value and help to prevent erroneous assumptions and biased results. To ensure that encoding of missing data is sufficient to understand the reason why data are missing, it should ideally be context-free...
2017: PloS One
https://www.readbyqxmd.com/read/28827317/coevolutionary-arms-race-versus-host-defense-chase-in-a-tropical-herbivore-plant-system
#18
María-José Endara, Phyllis D Coley, Gabrielle Ghabash, James A Nicholls, Kyle G Dexter, David A Donoso, Graham N Stone, R Toby Pennington, Thomas A Kursar
Coevolutionary models suggest that herbivores drive diversification and community composition in plants. For herbivores, many questions remain regarding how plant defenses shape host choice and community structure. We addressed these questions using the tree genus Inga and its lepidopteran herbivores in the Amazon. We constructed phylogenies for both plants and insects and quantified host associations and plant defenses. We found that similarity in herbivore assemblages between Inga species was correlated with similarity in defenses...
September 5, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28821540/investigating-undergraduate-students-use-of-intuitive-reasoning-and-evolutionary-knowledge-in-explanations-of-antibiotic-resistance
#19
Melissa Richard, John D Coley, Kimberly D Tanner
Natural selection is a central concept throughout biology; however, it is a process frequently misunderstood. Bacterial resistance to antibiotic medications provides a contextual example of the relevance of evolutionary theory and is also commonly misunderstood. While research has shed light on student misconceptions of natural selection, minimal study has focused on misconceptions of antibiotic resistance. Additionally, research has focused on the degree to which misconceptions may be based in the complexity of biological information or in pedagogical choices, rather than in deep-seated cognitive patterns...
2017: CBE Life Sciences Education
https://www.readbyqxmd.com/read/28744665/perceived-discrimination-and-health-related-quality-of-life-gender-differences-among-older-african-americans
#20
Sheryl L Coley, Carlos F Mendes de Leon, Earlise C Ward, Lisa L Barnes, Kimberly A Skarupski, Elizabeth A Jacobs
PURPOSE: Emerging data suggest that African-American women may fare worse than African-American men in health-related quality-of-life (HRQOL). Perceived discrimination is an important contributor to poor health overall among African Americans, but few studies examined the intersecting effects of perceived discrimination and gender in explaining HRQOL disparities. We investigated gender differences in HRQOL and tested whether perceived discrimination accounted for these differences. METHODS: We examined data from the Chicago Health and Aging Project in which 5652 African-American adults aged 65 and older completed structured questionnaires about demographic and socioeconomic characteristics, HRQOL, perceived discrimination, and health-related variables...
December 2017: Quality of Life Research
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