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https://www.readbyqxmd.com/read/28438019/l-phenylalanine-tethered-naphthalene-diimide-based-aggregation-induced-green-emitting-organic-nanoparticles
#1
Pritam Choudhury, Krishnendu Das, Prasanta Kumar Das
The present article delineates the formation of green fluorescent organic nanoparticle through supramolecular aggregation of naphthalene diimide (NDI) based carboxybenzyl protected L-phenylalanine appended bola-amphiphile, NDI-1. The amphiphilic molecule is soluble in DMSO and with gradual addition of water within the DMSO solution, the amphiphile starts to get self-assembled via H-type aggregation to form spherical nanoparticles. These self-assembly of NDI-1 in presence of high amount of water, exhibited aggregation induced emission (AIE) through excimer formation...
April 24, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28435738/crystal-structure-of-2-2-2-azanidyl-benzyl-idene-amino-benzyl-idene-amino-4-chloro-phenol-ato-nickel-ii
#2
Fumiya Kobayashi, Atsushi Koga, Ryo Ohtani, Shinya Hayami, Masaaki Nakamura
The title complex, [Ni(C20H14ClN3O)], with an asymmetrically chloride-appended Schiff base ligand has been synthesized and structurally characterized at 100 K. In the compound, the central nickel(II) ion has a square-planar coordination geometry with N3O donors of the π-conjugated tetra-dentate Schiff base ligand. In the crystal, the complexes are connected into an inversion dimer via an Ni⋯Ni inter-action [3.1753 (5) Å] and a pair of π-π inter-actions [centroid-centroid distance = 3.8416 (16) Å]...
April 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/28433247/outpatient-laparoscopic-appendectomy-feasible-in-a-public-county-hospital
#3
David R Rosen, Kenji Inaba, Paul J Oh, Adam C Gutierrez, Aaron M Strumwasser, Subarna Biswas, Melody Cala, Glenn T Ault
BACKGROUND: Outpatient laparoscopic appendectomy is being used increasingly as a treatment option for acute, uncomplicated appendicitis. This was a prospective validation study in a large, urban, public safety-net hospital. STUDY DESIGN: From 2014 to 2016, all patients undergoing laparoscopic appendectomy for acute, uncomplicated appendicitis were enrolled in a prospective observational trial. Standard baseline perioperative practice (control group) was documented for 1 year...
March 13, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28432931/acute-appendicitis-presenting-as-an-abdominal-wall-abscess-a-case-report
#4
Khalid Ahmed, Suhail Hakim, Ahmed M Suliman, Ammar Aleter, Ayman El-Menyar, Sheriff Abdulazeim Mustafa, Ahmad Zarour, Hassan Al-Thani
INTRODUCTION: Amyand hernia (AH) is a rare type of hernia characterized by the presence of appendix vermiformis in the inguinal hernial sac. It is rarely reported in women. PRESENTATION OF CASE: We presented a case of a 60- year old woman who was admitted initially with an abdominal wall abscess and found to have perforated appendix in the right inguinal hernia. The patient underwent standard open appendectomy and the post-operative course was uneventful. DISCUSSION: The initial presentation of our case as an abdominal wall abscess is rare in the contemporary literature...
April 4, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28429952/rare-cases-imitating-acute-appendicitis-three-case-reports-and-a-review-of-literature
#5
L Kunovsky, Z Kala, L Mitas, V Can, J Dolina, E Nemcová, L Klvacova, T Gajdosova, I Penka
Acute appendicitis with its characteristic clinical course is one of the most common diagnoses that require urgent surgery. The following three case reports present patients with symptoms typical of acute appendicitis which was, however, not confirmed intraoperatively. Preoperative CT or MRI were not requested because symptoms clearly indicated acute appendicitis. The first case describes a male patient with right-sided diverticulitis, the second case report involves a pregnant woman in 33rd week of gestation with right adnexal torsion due to a dermoid cyst, and in the last report, a case of spontaneous perforation of appendiceal mucinous neoplasm is presented...
2017: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
https://www.readbyqxmd.com/read/28429342/assessment-of-serum-endothelin-1-levels-in-rat-appendicitis-model-and-the-effects-of-bosentan
#6
S B Sarsu, K Sahin, H Kilincaslan, S L Mirapoglu, N Buyukpınarbasili, M E Duz, I Aydogdu
OBJECTIVE: In this study, the diagnostic value of serum endothelin-1 (ET-1) levels and the therapeutic effects of bosentan have been investigated in an experimental appendicitis rat model. MATERIALS AND METHODS: Twenty-one male Sprague-Dawley rats were chosen for the study. The rats were allocated into three groups as follows: Group 1 (control, n = 7), Group 2 (appendicitis, n = 7), and Group 3 (bosentan treatment, n = 7). At the 6th hour of the experiment, Groups 1 and 2 received 2 ml saline, and group 3 received 30 mg/kg bosentan intraperitoneally...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28429060/engineered-jadomycin-analogues-with-altered-sugar-moieties-revealing-jads-as-a-substrate-flexible-o-glycosyltransferase
#7
Liyuan Li, Guohui Pan, Xifen Zhu, Keqiang Fan, Wubin Gao, Guomin Ai, Jinwei Ren, Mingxin Shi, Carlos Olano, José A Salas, Keqian Yang
Glycosyltransferases (GTs)-mediated glycodiversification studies have drawn significant attention recently, with the goal of generating bioactive compounds with improved pharmacological properties by diversifying the appended sugars. The key to achieving glycodiversification is to identify natural and/or engineered flexible GTs capable of acting upon a broad range of substrates. Here, we report the use of a combinatorial biosynthetic approach to probe the substrate flexibility of JadS, the GT in jadomycin biosynthesis, towards different non-native NDP-sugar substrates, enabling us to identify six jadomycin B analogues with different sugar moieties...
April 20, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28427379/novel-mutation-identified-in-severe-early-onset-tumor-necrosis-factor-receptor-associated-periodic-syndrome-a-case-report
#8
Suhas M Radhakrishna, Amy Grimm, Lori Broderick
BACKGROUND: Tumor Necrosis Factor Receptor-Associated Periodic Syndrome (TRAPS) is the second most common heritable autoinflammatory disease, typically presenting in pre-school aged children with fever episodes lasting 1-3 weeks. Systemic symptoms can include rash, myalgia, ocular inflammation, and serositis. CASE PRESENTATION: Here we report an unusual presentation of TRAPS in a 7 month old girl who presented with only persistent fever. She was initially diagnosed with incomplete Kawasaki Disease and received IVIG and infliximab; however, her fevers quickly recurred...
April 20, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28426126/actinomyces-in-pregnancy-a-review-of-the-literature
#9
Sarah M Estrada, Everett F Magann, Peter G Napolitano
Importance: Actinomyces is commonly found in many areas of the body where it derives a benefit without harming the host. When it does infect the host during pregnancy, is that infection a threat to the obstetric patient and does that infection cause adverse pregnancy outcomes? Objective: The aim of this study was to review what is known about Actinomyces infections and the impact of an Actinomyces infection on pregnancy outcomes. Evidence Acquisition: A PubMed search was undertaken with the search years unlimited to April 1, 2016, and restricted to articles in English...
April 2017: Obstetrical & Gynecological Survey
https://www.readbyqxmd.com/read/28425713/synthesis-of-diverse-n-acryloyl-azetidines-and-evaluation-of-their-enhanced-thiol-reactivities
#10
Maximilian D Palkowitz, Bo Tan, Haitao Hu, Kenneth Roth, Renato A Bauer
Acyl azetidines exhibit nonplanar hybridization, leading to lower amide-like character of the corresponding (O)C-N bonds. This impacts N-acryloyl azetidines by producing enhanced electrophilicy at appended Michael acceptors. Herein, reactivity data are reported in the presence of glutathione (GSH) in phosphate buffer (pH 7.4) at 37 °C. Wide reactivity ranges are observed by varying substitution at the Michael acceptor or by modulating the electron-withdrawing character of substituents at the C3 position of the azetidine...
April 20, 2017: Organic Letters
https://www.readbyqxmd.com/read/28424822/rapid-non-contrast-magnetic-resonance-imaging-for-post-appendectomy-intra-abdominal-abscess-in-children
#11
Megan H Lee, Eric P Eutsler, Elizabeth F Sheybani, Geetika Khanna
BACKGROUND: Acute appendicitis, especially if perforated at presentation, is often complicated by postoperative abscess formation. The detection of a postoperative abscess relies primarily on imaging. This has traditionally been done with contrast-enhanced computed tomography. Non-contrast magnetic resonance imaging (MRI) has the potential to accurately detect intra-abdominal abscesses, especially with the use of diffusion-weighted imaging (DWI). OBJECTIVE: To evaluate our single-center experience with a rapid non-contrast MRI protocol evaluating post-appendectomy abscesses in children with persistent postsurgical symptoms...
April 20, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28424152/acute-appendicitis
#12
REVIEW
Daniel L H Baird, Constantinos Simillis, Christos Kontovounisios, Shahnawaz Rasheed, Paris P Tekkis
No abstract text is available yet for this article.
April 19, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28424136/the-role-of-doctors-and-patients-in-appendicitis-perforation
#13
Alaattin Öztürk, Mevlit Korkmaz, Talha Atalay, Yüksel Karaköse, Ömer Faruk Akinci, Mikdat Bozer
In this study, we aimed to determine factors that cause appendix perforations and to identify the role of physicians and patients in contributing to the cause of these perforations. This study was conducted between April 2010 and May 2015 and included 64 patients with perforated appendicitis. Patients' medical records were examined for factors that might have contributed to perforation, and the roles of patients and physicians in perforation appendicitis were evaluated. The perforation rate of patients with appendicitis was 16...
April 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28423177/comparison-of-appendectomy-outcomes-between-senior-general-surgeons-and-general-surgery-residents
#14
Baha Siam, Abbas Al-Kurd, Natalia Simanovsky, Haitham Awesat, Yahav Cohn, Brigitte Helou, Ahmed Eid, Haggi Mazeh
Importance: In some centers, the presence of a senior general surgeon (SGS) is obligatory in every procedure, including appendectomy, while in others it is not. There is a relative paucity in the literature of reports comparing the outcomes of appendectomies performed by unsupervised general surgery residents (GSRs) with those performed in the presence of an SGS. Objective: To compare the outcomes of appendectomies performed by SGSs with those performed by GSRs...
April 19, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28421971/-posttraumatic-appendicitis
#15
S Klis, T L Trang, M F Lutke Holzik
BACKGROUND: Posttraumatic appendicitis is an appendicitis that develops as a consequence of abdominal trauma. Trauma is a relatively rare cause of appendicitis which is nowadays rarely mentioned in surgical textbooks. CASE DESCRIPTION: We describe the case of a 12-year-old girl who presented to the emergency department six days after abdominal trauma caused by a fall from an electrical bicycle, complaining of fever and abdominal pain. Her symptoms were caused by a perforated appendicitis...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28421569/two-step-procedure-for-complicated-appendicitis-with-perityphlitic-abscess-formation
#16
Almir Miftaroski, Ulf Kessler, Etienne Monnard, Bernhard Egger
PRINCIPLES: Optimal management of perforated appendicitis with perityphlitic phlegmon or abscess formation is controversial. The aim of the study was to assess the outcome after a two-step procedure to treat patients with perityphlitic abscess formation. METHODS: We retrospectively assessed prospectively collected data from a single-centre database that included adult patients who had appendicitis and perityphlitic abscess (>=3 cm) but no generalised peritonitis, and were treated in 2007-2015...
April 19, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28418493/the-threat-of-diagnostic-uncertainty-in-the-medical-management-of-uncomplicated-appendicitis
#17
Richard G Bachur, Shawn J Rangel
No abstract text is available yet for this article.
April 17, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28418369/-optimization-of-tissue-reparation-at-treatment-by-remaxol
#18
A P Vlasov, P P Zaitzcev, P A Vlasov, G A Shevalaev, T I Vlasova, E I Polozova, S V Kononenko, A L Kovalenko
AIM: Studying influence of remaxol on reparative process of tissue reparation in a laparotomy wound. MATERIAL AND METHODS: 90 patients with the acute appendicitis complicated by local peritonitis in the early postoperative period are examined. 50 patients received traditional therapy. Therapy of other 40 patients included Remaxol (intravenous introduction, daily within 5 days, of 400 ml). RESULTS AND CONCLUSION: It is established that Remaxol optimizes the course of reparative process in laparotomy wound that was confirmed with data of tenziomety and wound exudate cytological research...
2017: Khirurgiia
https://www.readbyqxmd.com/read/28418367/-the-use-of-computed-tomography-in-the-diagnosis-of-acute-appendicitis
#19
S A Sovtsov, Zh A Revel-Muroz, V Yu Shkarednykh
AIM: To present the use of computed tomography in the diagnosis of acute appendicitis. MATERIAL AND METHODS: The study was conducted in 139 patients who were hospitalized with suspected acute appendicitis. However, the diagnosis was not clearly confirmed by clinical and ultrasonic data. RESULTS: Computed tomography confirmed/rejected presumptive diagnosis in 90.8% of patients. It was concluded that CT has high diagnostic accuracy to confirm acute appendicitis...
2017: Khirurgiia
https://www.readbyqxmd.com/read/28415777/the-immune-impact-of-mimic-endoscopic-retrograde-appendicitis-therapy-and-appendectomy-on-rabbits-of-acute-appendicitis
#20
Suqin Liu, Fenghua Pei, Xinhong Wang, Deliang Li, Lixia Zhao, Yanyan Song, Zhendong Chen, Bingrong Liu
This study was conducted to evaluate the immune impact of mimic endoscopic retrograde appendicitis therapy and appendectomy on rabbits of acute suppurative appendicitis and to determine whether TLR4/MYD88/NF-κB signaling pathway was activated in this process. 48 rabbits were assigned into 4 groups: group I, the mimic endoscopic retrograde appendicitis therapy group; group II, the appendectomy group; group III, the model group; and group IV, the blank group. White blood cells decreased, while levels of C-reactive protein, tumor necrosis factor-α, interleukin-6, interleukin-4, and interleukin-10 increased on the 2nd day in group I and II...
March 15, 2017: Oncotarget
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