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https://www.readbyqxmd.com/read/28346592/medical-treatment-of-pediatric-appendicitis-are-we-there-yet
#1
Monica E Lopez, David E Wesson
No abstract text is available yet for this article.
March 27, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28346589/comparison-of-antibiotic-therapy-and-appendectomy-for-acute-uncomplicated-appendicitis-in-children-a-meta-analysis
#2
Libin Huang, Yuan Yin, Lie Yang, Cun Wang, Yuan Li, Zongguang Zhou
Importance: Antibiotic therapy for acute uncomplicated appendicitis is effective in adult patients, but its application in pediatric patients remains controversial. Objective: To compare the safety and efficacy of antibiotic treatment vs appendectomy as the primary therapy for acute uncomplicated appendicitis in pediatric patients. Data Sources: The PubMed, MEDLINE, EMBASE, and Cochrane Library databases and the Cochrane Controlled Trials Register for randomized clinical trials were searched through April 17, 2016...
March 27, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28346288/day-surgery-for-acute-appendicitis-in-adults-a-prospective-series-of-102-patients
#3
Christian Hobeika, Thevy Hor, Nathalie Chereau, Anais Laforest, Radu Bachmann, Isabelle Sourouille, Najim Chafai, Yann Parc, Marc Beaussier, Jérémie H Lefèvre
AIM: To report the results of a consecutive series of day surgery appendectomy (DSA) for acute appendicitis. METHODS: Selection criteria for DSA were as follows: body mass index<28 kg/m, white cell count <15,000/mL, C-reactive protein<30 mg/L, no radiological signs of perforation, and appendix diameter ≤10 mm. All patients with radiologically proven appendicitis and 4 or 5 criteria were proposed for DSA and prospectively included. RESULTS: A total of 102 patients (female=39...
March 24, 2017: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/28345248/application-of-thiol-yne-thiol-ene-reactions-for-peptide-and-protein-macrocyclizations
#4
Yuanxiang Wang, Benjamin Bruno, Sean Cornillie, Jason Nogueira, Diao Chen, Thomas Cheatham, Carol Lim, Danny Chou
We report the application of thiol-yne/thiol-ene reactions to synthesize mono- and bicyclic stapled peptides and proteins. We first developed a thiol-ene based peptide stapling method in aqueous conditions. This method enabled us to efficiently staple recombinantly expressed coil-coiled proteins. The resulting stapled protein demonstrates higher stability in its secondary structure than the unstapled version. Furthermore, we performed a thiol-yne coupling by using an α,ω-diyne to react with two cysteine residues to synthesize a stapled peptide with two vinyl sulfide groups...
March 26, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28345068/how-much-risk-are-emergency-department-patients-willing-to-accept-to-avoid-diagnostic-testing
#5
Jeremy Padalecki, K Tom Xu, Cynthia Smith, Lynn Carrasco, Justin Hensley, Peter B Richman
OBJECTIVES: There is a paucity of research evaluating the risk tolerance of Emergency Department (ED) patients. We hypothesized that a significant percentage of ED patients surveyed would be comfortable with ≥5% risk of adverse outcome if they avoided testing in several hypothetical scenarios. MATERIALS AND METHODS: This was a cross-sectional study of a convenience sample of stable inner-city ED patients. Patients completed a written survey and were asked four closed-answer questions regarding risk tolerance/willingness to refuse a test/procedure, including the following scenarios: #1: LP following CT head; #2 overnight serial troponins for rule out myocardial infarction; #3 CT for possible appendicitis, #4 parent deciding whether child should undergo head CT for low risk head injury...
March 2017: Turkish Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28343153/de-garengeot-s-hernia-an-unusual-case-on-call
#6
Madeline Moore, Bassem Amr
De Garengeot's hernia is defined as a femoral hernia that contains the appendix. Owing to the extreme rarity of de Garengeot's hernia, it could represent a diagnostic challenge; however, it should remain in the differential diagnosis, particularly in this patient demographic. A female patient aged 96 years, who presented as an emergency with acute right iliac fossa pain, was found to have de Garengeot's hernia. The diagnosis was made intraoperatively, where she was treated with an appendicectomy and repair of the hernia defect...
March 24, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28341916/long-term-results-following-antibiotic-treatment-of-acute-appendicitis-in-adults
#7
K Lundholm, J Hansson-Assarsson, C Engström, B-M Iresjö
BACKGROUND: Antibiotic treatment of acute appendicitis has gained interest and inquiries. Reports have demonstrated both safety and high resolution of symptoms and inflammation following antibiotic treatment of appendicitis, but information on long-term results is required. Our present aim was therefore to evaluate long-term recurrence rate of initial antibiotics-alone treatment for suspected acute appendicitis. METHODS: Patients with favourable response to antibiotics in earlier randomized (RCT, n = 97) and population-based (PBT, n = 342) studies as well as subsequently treated non-randomized (Non-R, n = 271) patients are evaluated for long-term risk to relapse demanding surgical appendectomy; altogether 710 patients...
March 24, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28341505/secondary-aortoenteric-erosion-followed-by-recurrent-lower-extremity-abscesses
#8
Shigeshi Ono, Yoshitomo Samejima, Susumu Watada, Toshihiro Kakefuda
A secondary aortoenteric fistula (SAEF) is a relatively rare complication of aortoiliac reconstructive surgery, often involving relatively fixed duodenal 3(rd) portion and a vascular anastomosis. We observed a 52-year-old man with a recurrent right lower leg abscess following the erosion between ipsilateral bifurcated prosthetic graft limb and non-fixed jejunum. In situ graft-sparing surgical treatment with aggressive debridement was successfully performed. A SAEF may occur even at a non-vascular anastomosis site, or in non-fixed small bowel, and may become a source of a septic embolus...
March 21, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28338596/operation-versus-antibiotics-the-appendicitis-conundrum-continues-a-meta-analysis
#9
Joseph V Sakran, Konstantinos S Mylonas, Alexandros Gryparis, Stanislaw P Stawicki, Christopher J Burns, Maher M Matar, Konstantinos P Economopoulos
BACKGROUND: Acute appendicitis continues to constitute a diagnostic and therapeutic challenge. The aim of this study was to synthesize evidence from randomized controlled trials (RCTs) comparing nonoperative versus surgical management of uncomplicated acute appendicitis in adult patients. METHODS: A systematic literature search of the PubMed, Cochrane and Scopus databases was performed with respect to the PRISMA statement (end-of-search date: January 29, 2017). Data on the study design, interventions, participants, and outcomes were extracted by two independent reviewers...
March 23, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28337350/seat-belt-compression-appendicitis-following-motor-vehicle-collision
#10
Muhammad Faisal Khilji, Qazi Zia Ullah
Appendicitis and trauma both present in emergency department commonly but their presentation together in the same patient is unusual. We present a case of a middle-aged man brought by emergency medical services (EMS) to the emergency department with complaints of abdominal pain after he was involved in motor vehicle collision. He was perfectly fine before the accident. His primary survey was normal. Secondary survey revealed tenderness in right iliac fossa with seat belt mark overlying it. Computerized tomography (CT) of the abdomen and pelvis was performed which showed 8 mm thickening of appendix with minimal adjacent fat stranding...
2017: Case Reports in Emergency Medicine
https://www.readbyqxmd.com/read/28334480/zirconacyclopentadiene-annulated-polycyclic-aromatic-hydrocarbons
#11
Gavin R Kiel, Micah S Ziegler, T Don Tilley
Syntheses of large polycyclic aromatic hydrocarbons (PAHs) and graphene nanostructures demand methods that are capable of selectively and efficiently fusing large numbers of aromatic rings, yet such methods remain scarce. Herein, we report a new approach that is based on the quantitative intramolecular reductive cyclization of an oligo(diyne) with a low-valent zirconocene reagent, which gives a PAH with one or more annulated zirconacyclopentadienes (ZrPAHs). The efficiency of this process is demonstrated by a high-yielding fivefold intramolecular coupling to form a helical ZrPAH with 16 fused rings (from a precursor with no fused rings)...
March 23, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28333639/robust-dynamic-multi-objective-vehicle-routing-optimization-method
#12
Yi-Nan Guo, Jian Cheng, Sha Luo, Dun-Wei Gong
For dynamic multi-objective vehicle routing problems, the waiting time of vehicle, the number of serving vehicles, the total distance of routes were normally considered as the optimization objectives. Except for above objectives, fuel consumption that leads to the environmental pollution and energy consumption was focused on in this paper. Considering the vehicles' load and the driving distance, corresponding carbon emission model was built and set as an optimization objective. Dynamic multi-objective vehicle routing problems with hard time windows and randomly appeared dynamic customers, subsequently, were modeled...
March 21, 2017: IEEE/ACM Transactions on Computational Biology and Bioinformatics
https://www.readbyqxmd.com/read/28332718/lower-risk-for-cardiovascular-mortality-for-patients-with-root-filled-teeth-in-a-finnish-population
#13
J H Meurman, S-J Janket, M Surakka, E A Jackson, L K Ackerson, H R Fakhri, S Chogle, A Walls
AIM: To investigate the relationship of radiographic evidence of root filled teeth to cardiovascular outcomes. METHODOLOGY: Baseline data for 506 subjects including 256 angiographically verified heart disease patients and 250 matched cardiologically healthy controls participating in the Kuopio Oral Health and Heart study were collected in 1995-1996. Cardiovascular disease (CVD) mortalities were accrued until May 31(st) 2015 and appended to the baseline data. Mortality status data were obtained from the Finnish National Death Register where all mortality cases and the causes of death are compiled for all Finnish citizens...
March 23, 2017: International Endodontic Journal
https://www.readbyqxmd.com/read/28331263/clinical-profile-of-surgical-diseases-with-emergence-of-new-problems-in-hiv-individuals
#14
Tejaswini Vallabha, Mandar Dhamangaonkar, Vikram Sindgikar, Ravindra Nidoni, Harshavardhan Biradar, Aniketan Kv, Ramakant Baloorkar
North Karnataka is one of the regions with the high prevalence of HIV+ individuals. Bijapur is a district in North Karnataka with high prevalence as per fact sheets of NACO of March 2012. Better awareness, access to health care, and antiretroviral therapy have improved survival and increase in number of people living with HIV/AIDS (PLHA). Improved survival has increased their attendance to hospitals with variety of surgical problems, some known and some less known. The percentage of HIV+ individuals was 1.64 % among all admissions...
February 2017: Indian Journal of Surgery
https://www.readbyqxmd.com/read/28330350/communication-calculations-of-the-2-%C3%A3-1-o-reconstruction-kinetics-on-cu-110
#15
Xin Lian, Penghao Xiao, Renlong Liu, Graeme Henkelman
Density functional theory calculations are used to study the elementary processes of the formation of the (2 × 1)-O reconstruction on the Cu(110) surface. The (2 × 1)-O reconstruction requires additional Cu atoms to form Cu-O rows on top of the surface. Both terrace and step sites are considered as the source of Cu adatoms. On terraces, adsorbed oxygen induces the ejection of Cu atoms to form -O-Cu-O- units, leaving Cu vacancies behind. The barrier for subsequent unit growth, however, is prohibitively high...
March 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28329922/recurrent-abdominal-pain-after-laparoscopic-appendectomy
#16
Kwang Il Seo, Sung Eun Kim, Moo In Park, Seun Ja Park, Won Moon, Jae Hyun Kim, Kyoungwon Jung, Jung Gu Park
Laparoscopic surgical approaches, compared with open surgical approaches, provide comparable clinical outcomes, but lower complications. Unfortunately, a rare complication-portomesenteric vein thrombosis-had been reported after laparoscopic surgery. A 42-year-old woman was referred our hospital for recurrent abdominal pain after laparoscopic appendectomy from acute appendicitis. It was determined that abdominal pain was due to postoperative superior mesenteric vein thrombus. A six-month anticoagulation therapy is an excellent treatment for superior mesenteric vein thrombus ...
March 25, 2017: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/28327771/the-roles-of-surface-chemistry-dissolution-rate-and-delivered-dose-in-the-cytotoxicity-of-copper-nanoparticles
#17
Miao Shi, Karen L de Mesy Bentley, Goutam Palui, Hedi Mattoussi, Alison Elder, Hong Yang
The understanding of nanoparticle (NP) cytotoxicity is challenging because of incomplete information about physicochemical changes particles undergo once they come into contact with biological fluids. It is therefore essential to characterize changes in NP properties to better understand their biological fate and effects in mammalian cells. In this paper, we present a study on the effect of particle surface oxidation and dissolution rates of Cu NPs. Particle dissolution, cell-associated Cu doses, and oxidative stress responses in A549 luciferase reporter cells were examined for Cu NPs modified with mercaptocarboxylic acids with different carbon chain lengths and a thiotic acid appended-PEG ligand (TA)...
March 22, 2017: Nanoscale
https://www.readbyqxmd.com/read/28327738/hydroxide-bridged-dicopper-complexes-the-influence-of-secondary-coordination-sphere-on-structure-and-catecholase-activity
#18
Deepak Bansal, Rajeev Gupta
Amide-based ligands (H2L(1-6)) with assorted functional groups appended to them have been used for the synthesis of dicopper(ii) complexes 1-6 having a Cu(μ-OH)Cu core. The crystal structures of 1-6 show that while every Cu(ii) ion is ligated within the N3 pincer cavity of a potentially multidentate ligand, two Cu(ii) centers are bridged by a hydroxide group. Notably, the Cu(μ-OH)Cu core is encased within the secondary coordination sphere intricately created by the appended groups. While complexes 1 and 2 exhibit the presence of an H-bond acceptor in the proximity of the Cu(μ-OH)Cu core, complexes 3 and 4 display the occurrence of both the H-bond donor as well as H-bond acceptor groups in the vicinity of the Cu(μ-OH)Cu core...
March 22, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28325342/cyclodextrin-based-sustained-and-controllable-release-system-of-insulin-utilizing-the-combination-system-of-self-assembly-pegylation-and-polypseudorotaxane-formation
#19
Tatsunori Hirotsu, Taishi Higashi, Keiichi Motoyama, Hidetoshi Arima
Sustained and controllable release of insulin is strongly required to achieve the ideal treatment of diabetes. We previously developed "self-assembly PEGylation retaining activity (SPRA) technology" via a host-guest interaction between PEGylated β-cyclodextrin and adamantane-appended insulin, and resulting PEGylated insulin was termed SPRA-insulin. So far, we also demonstrated that covalently PEGylated insulin forms polypseudorotaxanes (PPRXs) with cyclodextrins (PPRX technology). In the present study, we designed and evaluated the combination system of SPRA technology and PPRX technology to achieve a sustained and controllable release system of insulin...
May 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28319797/non-enolisable-knoevenagel-condensate-appended-schiff-bases-metal-ii-complexes-spectral-characteristics-dna-binding-and-nuclease-activities
#20
Ammavasi Gubendran, Mookkandi Palsamy Kesavan, Srinivasan Ayyanaar, Liviu Mitu, Periyakaruppan Athappan, Jegathalaprathaban Rajesh
New Schiff base complexes [Cu(L(1))Cl] (1), [Ni(L(1))Cl] (2), [Zn(L(1))Cl] (3), and [Fe(L(2))H2OCl] (4) {L(1)=(4E)-3-(2-hydroxybenzylidene)-4-(2-hydroxyphenylimino)pentan-2-one, L(2)=2,2'-(1E,1'E)-(3-(2-hydroxybenzylidene)-pentane-2,4-diylidene)bis(azan-1-yl-1 idene)diphenol} have been synthesized and characterized by elemental analysis, UV-Vis, IR, FAB-mass, EPR, spectral studies and electrochemical studies, the ligands L(1) &L(2) were characterized by (1)H and (13)C NMR spectra. Complex 1 show a visible spectral d-d band near 600nm and display cyclic voltammetric quasireversible response for the Cu(II)/Cu(I) couple vs Ag/AgCl in DMSO...
March 16, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
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