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https://www.readbyqxmd.com/read/29168485/catalyst-controlled-oligomerization-for-the-collective-synthesis-of-polypyrroloindoline-natural-products
#1
Christopher R Jamison, Joseph J Badillo, Jeffrey M Lipshultz, Robert J Comito, David W C MacMillan
In nature, many organisms generate large families of natural product metabolites that have related molecular structures as a means to increase functional diversity and gain an evolutionary advantage against competing systems within the same environment. One pathway commonly employed by living systems to generate these large classes of structurally related families is oligomerization, wherein a series of enzymatically catalysed reactions is employed to generate secondary metabolites by iteratively appending monomers to a growing serial oligomer chain...
December 2017: Nature Chemistry
https://www.readbyqxmd.com/read/29168372/tuba-ovarian-auto-amputation-caused-by-ovarian-teratoma-in-an-adolescent-girl
#2
Ahmet Atıcı, Engin Yılmaz, Ayşe Karaman, Sema Apaydın, Çağatay Evrim Afşarlar
Atıcı A, Yılmaz E, Karaman A, Apaydın S, Afşarlar ÇE. Tuba-ovarian auto-amputation caused by ovarian teratoma in an adolescent girl. Turk J Pediatr 2017; 59: 90-92. Ovarian auto-amputation is an extremely rare condition commonly encountered in the perinatal period. Spontaneous or secondary torsion of the ovary caused by an ovarian lesion may result in infarction and subsequent auto-amputation of the ovary. This paper demonstrates a case that underwent laparoscopic appendectomy with an incidental calcified auto-amputated right ovary...
2017: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/29162805/the-key-role-of-au-substrate-interactions-in-catalytic-gold-subnanoclusters
#3
Jesús Cordón, Gonzalo Jiménez-Osés, José M López-de-Luzuriaga, Miguel Monge
The development of gold catalysis has allowed significant levels of activity and complexity in organic synthesis. Recently, the use of very active small gold subnanoclusters (Au n , n < 10) has been reported. The stabilization of such nanocatalysts to prevent self-aggregation represents a true challenge that has been partially remediated, for instance, by their immobilization in polymer matrices. Here, we describe the transient stabilization of very small gold subnanoclusters (Au n , n < 5) by alkyl chains or aromatic groups appended to the reactive π bond of simple alkynes...
November 21, 2017: Nature Communications
https://www.readbyqxmd.com/read/29160493/neonatal-appendicitis-a-survival-case-study
#4
Izabela Linha Secco, Taine Costa, Etiene Letícia Leone de Moraes, Márcia Helena de Souza Freire, Mitzy Tannia Reichembach Danski, Regina Paula Guimarães Vieira Cavalcante
OBJECTIVE: To report a case of neonatal appendicitis in a children's hospital in southern Brazil, demonstrating the impact on neonatal survival. METHOD: Case study with data collection from medical records, approved by the Institution and Ethics Committee for Research with Human Beings. RESULTS: The clinical picture is initially characterized by food intolerance, evolving to hypoactivity, alteration of vital signs and septicemia due to intestinal perforation...
November 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29159839/increased-renal-echogenicity-in-children-with-appendicitis
#5
Hila Tal, Daniel Ben-Mordechay, Aviva Ben-Shlush, Lisa Raviv-Zilka, Michalle Soudack
OBJECTIVES: Ultrasound (US) is an important modality for the detection of acute appendicitis in children but has limited sensitivity and specificity. Therefore, additional US findings may contribute to the diagnosis. In our experience, children with acute appendicitis often have increased renal cortical echogenicity on US imaging. The purpose of this study was to examine the association of increased renal cortical echogenicity with appendicitis. METHODS: This study included 240 consecutive pediatric patients with no renal or liver disease who underwent US examinations for suspected appendicitis between February 2014 and January 2016...
November 21, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29157691/nonoperative-management-of-appendicitis-a-paradigm-shift-answers-to-the-july-2017-journal-club-questions
#6
Callie M Thompson, Wesley H Self, Tyler W Barrett
No abstract text is available yet for this article.
December 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/29157344/you-re-the-flight-surgeon
#7
(no author information available yet)
Newbold PR. You're the flight surgeon: acute appendicitis. Aerosp Med Hum Perform. 2017; 88(12):1134-1137.
December 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29156146/effectiveness-of-a-staged-us-and-unenhanced-mr-imaging-algorithm-in-the-diagnosis-of-pediatric-appendicitis
#8
Elizabeth H Dibble, David W Swenson, Claudia Cartagena, Grayson L Baird, Thaddeus W Herliczek
Purpose To establish, in a large cohort, the diagnostic performance of a staged algorithm involving ultrasonography (US) followed by conditional unenhanced magnetic resonance (MR) imaging for the imaging work-up of pediatric appendicitis. Materials and Methods A staged imaging algorithm in which US and unenhanced MR imaging were performed in pediatric patients suspected of having appendicitis was implemented at the authors' institution on January 1, 2011, with US as the initial modality followed by unenhanced MR imaging when US findings were equivocal...
November 20, 2017: Radiology
https://www.readbyqxmd.com/read/29155269/influence-of-time-to-appendectomy-and-operative-duration-on-hospital-cost-in-children-with-uncomplicated-appendicitis
#9
Stephanie K Serres, Dionne A Graham, Charity C Glass, Danielle B Cameron, Seema P Anandalwar, Shawn J Rangel
BACKGROUND: The goal of this study was to examine the influence of time to appendectomy (TTA) and operative duration (OD) on hospital cost as surrogate measures of perioperative efficiency. STUDY DESIGN: Retrospective cohort analysis of 2,116 children undergoing appendectomy for uncomplicated appendicitis at 16 children's hospitals from 1/2013 to 12/2014. TTA (emergency department presentation to incision) and OD were obtained from the NSQIP-Pediatric Appendectomy Pilot Database and merged with cost data from the Pediatric Health Information System Database...
November 16, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29155250/surgical-management-of-acute-appendicitis-in-adults-a-review-of-current-techniques
#10
REVIEW
Maximilian Sohn, Ayman Agha, Stefan Bremer, Kai S Lehmann, Marcus Bormann, Alfred Hochrein
Acute appendicitis is one of the most frequent disorders in abdominal surgery. Therefore, appendectomy is a matter of significant interest in that field. Yet, four different techniques are available: open appendectomy, (conventional) laparoscopic appendectomy, single port laparoscopic appendectomy and NOTES-appendectomy with its different variations. To evaluate the current state of the art in appendectomy a bibliographic search was conducted. All prospectively randomized trials and national register cohort studies published between 1/2010 and 5/2016 were included into the analysis...
November 18, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/29153247/early-versus-delayed-appendectomy-a-comparison-of-outcomes
#11
Kyle Seudeal, Hira Abidi, Saad Shebrain
BACKGROUND: The optimal timing for performing appendectomy in adults remains controversial. METHOD: A one-year retrospective review of adult patients with acute appendicitis who underwent appendectomy. The cohort was divided by time-to-intervention into two groups: patients who underwent appendectomy within 8 h (group 1), and those who had surgery after 8 h (group 2). Outcome measures including perioperative morbidity and mortality, post-operative length of stay, and the 30-day readmission rate were compared between the two groups...
November 11, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/29152626/specific-recognition-of-cr-3-under-physiological-conditions-by-allyl-substituted-appendage-rhodamine-and-its-cell-imaging-studies
#12
Anup Kumar Bhanja, Snehasis Mishra, Kaushik Naskar, Suvendu Maity, Krishna Das Saha, Chittaranjan Sinha
An allyloxynitrophenylimio-propylhydroxyl appended rhodamine (RD-3) specifically recognises Cr(3+) in aqueous buffer medium at pH 7.4. The visible light excitable reagent (λex 505 nm) on selective binding to Cr(3+) exhibited a strong fluorescence turn-on response with powerful emission at 557 nm and the tail of this luminescence band is extended to ∼650 nm. Interference studies confirm that other metal ions (27 ions) do not hamper the detection process of Cr(3+). The sensing mechanism is studied by absorption, fluorescence, Job's plot, and (1)H NMR titration studies...
November 20, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29152421/severe-acute-respiratory-distress-syndrome-after-laparoscopic-appendectomy-in-a-young-adult
#13
Gabriel O Ologun, Daniel Ridley, Nhean D Chea, Daniel Golden, Anne Lihau-N'Kanza, Philip McPhail
Severe acute respiratory distress syndrome after laparoscopic appendectomy for acute appendicitis in a young adult is an uncommon complication. We describe the case of a 25-year-old male who developed severe acute respiratory distress syndrome after an uneventful laparoscopic appendectomy for a perforated appendix, requiring mechanical ventilation in the intensive care unit.
September 8, 2017: Curēus
https://www.readbyqxmd.com/read/29151848/developing-and-validating-of-ramathibodi-appendicitis-score-rama-as-for-diagnosis-of-appendicitis-in-suspected-appendicitis-patients
#14
Chumpon Wilasrusmee, Boonying Siribumrungwong, Samart Phuwapraisirisan, Napaphat Poprom, Patarawan Woratanarat, Panuwat Lertsithichai, John Attia, Ammarin Thakkinstian
Background: Diagnosis of appendicitis is still clinically challenging where resources are limited. The purpose of this study was to develop and externally validate Ramathibodi Appendicitis Score (RAMA-AS) in aiding diagnosis of appendicitis. Methods: A two-phase cross-sectional study (i.e., derivation and validation) was conducted at Ramathibodi Hospital (for derivation) and at Thammasat University Hospital and Chaiyaphum Hospital (for validation). Patients with abdominal pain and suspected of having appendicitis were enrolled...
2017: World Journal of Emergency Surgery: WJES
https://www.readbyqxmd.com/read/29148199/five-lessons-in-uncomplicated-appendicitis-can-we-remove-the-surgery
#15
Andrew Read, Jane Xu, Susan Adams, Jonathan Karpelowsky
Appendicectomy has remained the treatment of choice for appendicitis for over a century and is the most commonly performed emergency operation in children. However, emerging evidence suggests that appendicectomy may not always be necessary in uncomplicated appendicitis, with early paediatric trials demonstrating that antibiotic-only therapy can be safe and effective. Further rigorously designed and appropriately powered studies are necessarily to establish the place of non-operative management of uncomplicated appendicitis in the future...
November 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29146647/initial-non-operative-management-of-uncomplicated-appendicitis-in-children-a-protocol-for-a-multicentre-randomised-controlled-trial-apac-trial
#16
Max Knaapen, Johanna H van der Lee, Roel Bakx, Sarah-May L The, Ernst W E van Heurn, Hugo A Heij, Ramon R Gorter
INTRODUCTION: Based on epidemiological, immunological and pathology data, the idea that appendicitis is not necessarily a progressive disease is gaining ground. Two types are distinguished: simple and complicated appendicitis. Non-operative treatment (NOT) of children with simple appendicitis has been investigated in several small studies. So far, it is deemed safe. However, its effectiveness and effect on quality of life (QoL) have yet to be established in an adequately powered randomised trial...
November 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/29146633/comparison-of-outcomes-of-antibiotic-drugs-and-appendectomy-coda-trial-a-protocol-for-the-pragmatic-randomised-study-of-appendicitis-treatment
#17
Giana H Davidson, David R Flum, David A Talan, Larry G Kessler, Danielle C Lavallee, Bonnie J Bizzell, Farhood Farjah, Skye D Stewart, Anusha Krishnadasan, Erin E Carney, Erika M Wolff, Bryan A Comstock, Sarah E Monsell, Patrick J Heagerty, Annie P Ehlers, Daniel A DeUgarte, Amy H Kaji, Heather L Evans, Julianna T Yu, Katherine A Mandell, Ian C Doten, Kevin S Clive, Karen M McGrane, Brandon C Tudor, Careen S Foster, Darin J Saltzman, Richard C Thirlby, Erin O Lange, Amber K Sabbatini, Gregory J Moran
INTRODUCTION: Several European studies suggest that some patients with appendicitis can be treated safely with antibiotics. A portion of patients eventually undergo appendectomy within a year, with 10%-15% failing to respond in the initial period and a similar additional proportion with suspected recurrent episodes requiring appendectomy. Nearly all patients with appendicitis in the USA are still treated with surgery. A rigorous comparative effectiveness trial in the USA that is sufficiently large and pragmatic to incorporate usual variations in care and measures the patient experience is needed to determine whether antibiotics are as good as appendectomy...
November 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/29146455/successful-nonoperative-management-of-uncomplicated-appendicitis-predictors-and-outcomes
#18
Tyler J Loftus, Scott C Brakenridge, Chasen A Croft, R Stephen Smith, Philip A Efron, Frederick A Moore, Alicia M Mohr, Janeen R Jordan
BACKGROUND: Our objective was to identify predictors of successful nonoperative management (NOM) of uncomplicated appendicitis. We hypothesized that the absence of diabetes, absence of an appendicolith, short duration of symptoms, absence of systemic inflammation, and low modified Alvarado score would predict successful NOM. METHODS: We performed a retrospective cohort analysis of 81 consecutive patients who underwent NOM of uncomplicated appendicitis. Successful NOM was defined as resolution of appendicitis with antibiotics alone and no recurrent appendicitis within 180 days...
November 13, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/29146070/acute-appendicitis-due-to-parasitosis
#19
Cristina Alejandre Villalobos, David Fernández-SanMillán, Eudaldo López-Tomassetti Fernández, Juan Ramón Hernández Hernández
No abstract text is available yet for this article.
November 13, 2017: Cirugía Española
https://www.readbyqxmd.com/read/29145325/perforated-appendicitis-after-colonoscopy-cause-or-coincidence-a-rare-case-report-and-literature-review
#20
Xiao-Cong Zhou, Chun-Wei Huang, Yan-Yan Dai, Zhi-Yang Huang, Zheng Lou
RATIONALE: Colonoscopy is a relatively safe and common procedure with low risks of complications, and acute appendicitis with perforation is an extremely rare complication of colonoscopy. The current study presents an unusual case of acute gangrenous appendicitis with perforation following a screening colonoscopy. PATIENT CONCERNS: A 73-year-old man presented to our emergency department with lower right abdominal pain 3 days after a routine screening colonoscopy...
November 2017: Medicine (Baltimore)
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