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Neurovascular imaging

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https://www.readbyqxmd.com/read/29341006/mapping-functional-connectivity-in-the-rodent-brain-using-electric-stimulation-fmri
#1
Laura Pérez-Cervera, José María Caramés, Luis Miguel Fernández-Mollá, Andrea Moreno, Begoña Fernández, Elena Pérez-Montoyo, David Moratal, Santiago Canals, Jesús Pacheco-Torres
Since its discovery in the early 90s, BOLD signal-based functional Magnetic Resonance Imaging (fMRI) has become a fundamental technique for the study of brain activity in basic and clinical research. Functional MRI signals provide an indirect but robust and quantitative readout of brain activity through the tight coupling between cerebral blood flow and neuronal activation, the so-called neurovascular coupling. Combined with experimental techniques only available in animal models, such as intracerebral micro-stimulation, optogenetics or pharmacogenetics, provides a powerful framework to investigate the impact of specific circuit manipulations on overall brain dynamics...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29336001/advances-in-the-study-of-the-middle-cranial-fossa-through-cutting-edge-neuroimaging-techniques
#2
Juan A Juanes Méndez, Pablo Ruisoto, Juan C Paniagua, Alberto Prats
The objective of this paper is to present a morphometric study of the middle cranial fossa from the study of 87 patients using cutting edge multislice computed tomography scans (32 detectors) and Magnetic Resonance Imaging. The study presents a detailed anatomical-radiological and morphometric analysis of the middle cranial fossa as well as its neurovascular elements in normal conditions. The implications of this investigation in training and clinical contexts are discussed.
January 16, 2018: Journal of Medical Systems
https://www.readbyqxmd.com/read/29332928/optical-coherence-tomography-for-precision-brain-imaging-neurosurgical-guidance-and-minimally-invasive-theranostics
#3
Yingwei Fan, Yan Xia, Xinran Zhang, Yu Sun, Jie Tang, Liwei Zhang, Hongen Liao
This review focuses on optical coherence tomography (OCT)-based neurosurgical application for imaging and treatment of brain tumors. OCT has emerged as one of the most innovative and successful translational biomedical-diagnostic techniques. It is a useful imaging tool for noninvasive, in vivo, in situ and real-time imaging in soft biological tissues, such as brain tumor imaging. OCT can detect the structure of biological tissue in a micrometer scale, and functional OCT has some clinical researches and applications, such as nerve fiber tracts and neurovascular imaging...
January 15, 2018: Bioscience Trends
https://www.readbyqxmd.com/read/29328980/consequence-of-intraventricular-hemorrhage-on-neurovascular-coupling-evoked-by-speech-syllables-in-preterm-neonates
#4
Mahdi Mahmoudzadeh, Ghislaine Dehaene-Lambertz, Guy Kongolo, Marc Fournier, Sabrina Goudjil, Fabrice Wallois
Intraventricular Hemorrhage (IVH) is the leading cause of neurological and cognitive impairment in preterm neonates with an incidence that increases with increasing prematurity. In the present study, we tested how preterm neonates with IVH react to external stimulation (i.e. speech syllables). We compared their neural responses measured by electroencephalography (EEG), and hemodynamic responses measured by functional near-infrared spectroscopy (fNIRS), with those of healthy preterms. A neural response to syllables was observed in these infants, but did not induce a vascular response in contrast with healthy neonates...
January 5, 2018: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/29327107/imaging-of-pediatric-neurovascular-emergencies
#5
Yang Tang, William C Goodman, Michael D Maldonado, Xinli Du
Pediatric strokes are rare but critical diagnoses to make in the emergency setting. They are associated with a set of pathologies that are not frequently encountered in the adult population. Some of these diseases have variable clinical presentations and imaging appearance depending on the age of onset and severity of the underlying pathologies. This article reviews the differential diagnoses and noninvasive imaging evaluation of pediatric cerebral ischemic and hemorrhagic diseases.
January 11, 2018: Emergency Radiology
https://www.readbyqxmd.com/read/29319657/sciatic-nerve-entanglement-around-a-femoral-prosthesis-during-closed-reduction-of-a-dislocated-total-hip-prosthesis-the-role-of-metal-suppression-mri-a-case-report
#6
Zoe B Cheung, Anik V Patel, Nicholas DeBellis, Douglas B Unis, Carlos L Benitez
CASE: A 68-year-old woman who had undergone a right total hip arthroplasty presented with a right posterior hip dislocation, and subsequently developed an ipsilateral sciatic nerve palsy after closed reduction. Magnetic resonance imaging (MRI) with metal suppression demonstrated sciatic nerve entanglement around the prosthetic femoral neck. A sciatic nerve release was performed, resulting in poor early neurologic recovery. CONCLUSION: Sciatic nerve entanglement following closed reduction of a dislocated total hip prosthesis is a rare injury...
January 10, 2018: JBJS Case Connector
https://www.readbyqxmd.com/read/29319656/isolated-rhabdomyolysis-of-the-infraspinatus-muscle-following-the-crossfit-sissy-test-a-report-of-two-cases
#7
Howard D Routman, Jacob J Triplet, Jennifer Kurowicki, Neil Singh
CASE: Following the completion of a CrossFit-style challenge (the "Sissy Test"), 2 patients presented with severe pain and swelling over the posterior aspect of the scapula. Magnetic resonance imaging demonstrated isolated edema of the infraspinatus muscle in both patients; the compartments were compressible. Neurovascular checks and observation of range of motion were performed. The patients were treated nonoperatively and were discharged with the diagnosis of overuse syndrome with rhabdomyolysis of the infraspinatus muscle...
January 10, 2018: JBJS Case Connector
https://www.readbyqxmd.com/read/29305127/7-0tesla-mri-tractography-in-patients-with-trigeminal-neuralgia
#8
Hyeong Cheol Moon, Soon-Tae You, Hyeon Man Baek, Young Jai Jeon, Chan-A Park, Jei Jun Cheong, Youn Joo Lee, Young Seok Park
7.0Tesla(T) high-resolution diffusion tensor imaging (DTI) can supply information on changing microstructures in cranial nerves. We investigated DTI parameters and the feasibility of DTI criteria for diagnosing trigeminal neuralgia (TN). In this study, 14 patients (28 hemispheres) of mean age 49.0years (range, 31-64) with TN underwent DTI using 7.0TMRI. We compared fractional anisotropy (FA), axial diffusivity (AD), mean diffusivity (MD), and radial diffusivity (RD) of affected-side and unaffected-side trigeminal nerves using DTI...
January 2, 2018: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29298859/fast-acquisition-cone-beam-computed-tomography-initial-experience-with-a-10-s-protocol
#9
Visish M Srinivasan, Gouthami Chintalapani, Kevin Matthew Camstra, Sabih T Effendi, Jacob Cherian, Jeremiah N Johnson, Stephen R Chen, Peter Kan
BACKGROUND: Cone-beam computed tomography (CBCT) facilitates the acquisition of cross-sectional imaging in angiography suites using a rotational C-arm and digital flat panel detectors. The applications are numerous, including evaluation of implanted devices and localization of cerebrovascular lesions. We present and validate the clinical utility of an alternative fast CBCT acquisition protocol in the context of neurovascular device imaging. METHODS: Contrast-enhanced (CE)-CBCT images were acquired using a new 10 s protocol in a phantom head model, swine model, and in patients...
January 3, 2018: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29296491/automated-segmentation-and-quantification-of-oct-angiography-for-tracking-angiogenesis-progression
#10
Ang Li, Jiang You, Congwu Du, Yingtian Pan
Angiogenesis is recognized as a crucial component of many neurovascular diseases such as stroke, carcinogenesis, and neurotoxicity of abused drug. The ability to track angiogenesis will facilitate a better understanding of disease progression and assessment of therapeutical effects. Optical coherence angiography (OCTA) is a promising tool to assess 3D microvascular networks due to its micron-level resolution, high sensitivity, and relatively large field of view. However, quantitative OCTA image analysis for characterization of microvascular network changes, including accurately tracking the progression of angiogenesis, remains a challenge...
December 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/29288851/flat-posterior-cranial-fossa-affects-outcomes-of-microvascular-decompression-for-trigeminal-neuralgia
#11
Toshiki Fukuoka, Yusuke Nishimura, Masahito Hara, Kei Nomura, Hiroshi Ryu, Satoshi Yoshikawa, Toshihiko Wakabayashi
OBJECTIVE: The aim of this study was to investigate prognostic factors for microvascular decompression (MVD) in patients with primary trigeminal neuralgia (TN), with a particular focus on the morphology of the posterior cranial fossa (PCF). METHODS: The present study investigated 126 surgically treated primary TN patients with more than 1-year follow-up who underwent high-resolution magnetic resonance imaging between April 2003 and September 2015. We retrospectively reviewed clinical information and operative findings...
December 27, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29279161/accuracy-of-multiparametric-mr-imaging-with-pi-rads-v2-assessment-in-detecting-infiltration-of-the-neurovascular-bundles-prior-to-prostatectomy
#12
Markus Sauer, Julius M Weinrich, Christoph Fraune, Georg Salomon, Pierre Tennstedt, Gerhard Adam, Dirk Beyersdorff
OBJECTIVES: To evaluate the accuracy of assessment of neurovascular bundle (NVB) infiltration using multiparametric magnetic resonance imaging (mpMRI) and PI-RADS V2 prior to prostatectomy. METHODS: The ethics committee approved this retrospective study with waiver of informed consent. N=198 consecutive patients with biopsy proved cancer underwent standardized mpMRI at 3T prior to surgery. NVB infiltration was assessed for each side (a total of 396). Maximum PI-RADS V2 scores were determined for the posterolateral areas adjacent to the NVBs...
January 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29276593/anterior-orbital-leiomyoma-originating-from-the-supraorbital-neurovascular-bundle
#13
Selam Yekta Sendul, Cemile Ucgul Atilgan, Fevziye Kabukcuoglu, Semra Tiryaki Demir, Dilek Guven
Purpose: To present a young female patient with left anterior orbital leiomyoma that originates from the supraorbital neurovascular bundle. Case presentation: A 41-year-old female patient was admitted to our clinic with a complaint of swelling of the left upper eyelid. Based on the ophthalmological and imaging assessments, the excisional biopsy with the preliminary diagnosis of dermoid cyst was planned. The histopathological and immunohistochemical examinations of excised sample revealed surprisingly that the tumour was a leiomyoma...
2017: SAGE Open Medical Case Reports
https://www.readbyqxmd.com/read/29276226/relationship-between-the-axillary-nerve-and-accompanying-vessels-and-proximal-humeral-locking-plates-in-japanese-an-mri-study
#14
Yoshimasa Sakoma, Takahiko Hirooka
We investigated the anatomical features of the axillary nerve and its accompanying vessels with respect to the lateral wall of the greater tuberosity, focusing on the relationship between the neurovascular bundle and the proximal humeral locking plates. Magnetic resonance images of 30 Japanese patients' shoulders were examined. Oblique sagittal images across the greater tuberosity and the neurovascular bundle, which contain the axillary nerve and posterior circumflex humeral artery and vein, were obtained. The distance between the superior aspect of the greater tuberosity and the superior and inferior borders of the neurovascular bundles was measured at the anterior, middle, and posterior edges of the greater tuberosity...
December 2017: Acta Medica Okayama
https://www.readbyqxmd.com/read/29251840/blood-brain-barrier-development-systems-modeling-and-predictive-toxicology
#15
REVIEW
Katerine S Saili, Todd J Zurlinden, Andrew J Schwab, Aymeric Silvin, Nancy C Baker, E Sidney Hunter, Florent Ginhoux, Thomas B Knudsen
The blood-brain barrier (BBB) serves as a gateway for passage of drugs, chemicals, nutrients, metabolites, and hormones between vascular and neural compartments in the brain. Here, we review BBB development with regard to the microphysiology of the neurovascular unit (NVU) and the impact of BBB disruption on brain development. Our focus is on modeling these complex systems. Extant in silico models are available as tools to predict the probability of drug/chemical passage across the BBB; in vitro platforms for high-throughput screening and high-content imaging provide novel data streams for profiling chemical-biological interactions; and engineered human cell-based microphysiological systems provide empirical models with which to investigate the dynamics of NVU function...
December 1, 2017: Birth Defects Research
https://www.readbyqxmd.com/read/29246609/safety-and-preliminary-efficacy-of-intravenous-tirofiban-in-acute-ischemic-stroke-patient-without-arterial-occlusion-on-neurovascular-imaging-studies
#16
Lu Lin, Wei Li, Cheng-Chun Liu, Ya Wu, Shu-Han Huang, Xiao-Shu Li, Chun-Rong Liang, Huan Wang, Li-Li Zhang, Zhi-Qiang Xu, Yan-Jiang Wang, Wuwei Feng, Meng Zhang
BACKGROUND: There has been no effective treatment for acute ischemic stroke (AIS) patients who presented to the Emergency Department >4.5h without a visible arterial occlusion on the neurovascular imaging studies. In this study, we aimed to investigate whether intravenous antiplatelet agent tirofiban was safe and potentially effective in AIS patients who had no visible arterial occlusion and was outside of treatment window for Alteplase. The goal of this study was to collect preliminary data to plan a future phase II study...
December 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29239685/in%C3%A2-vitro-angiographic-comparison-of-the-flow-diversion-performance-of-five-neurovascular-stents
#17
Ronak J Dholakia, Ari D Kappel, Andrew Pagano, Henry H Woo, Baruch B Lieber, David J Fiorella, Chander Sadasivan
Background and purpose Data differentiating flow diversion properties of commercially available low- and high-porosity stents are limited. This in vitro study applies angiographic analysis of intra-aneurysmal flow to compare the flow-diversion performance of five neurovascular devices in idealized sidewall and bifurcation aneurysm models. Methods Five commercial devices (Enterprise, Neuroform, LVIS, FRED, and Pipeline) were implanted in silicone sidewall and bifurcation aneurysm models under physiological average flow of blood analog fluid...
January 1, 2017: Interventional Neuroradiology
https://www.readbyqxmd.com/read/29236275/multidisciplinary-management-of-a-giant-cervico-mediastinal-liposarcoma-a-case-report-and-literature-review
#18
Andrea Galli, Leone Giordano, Piergiorgio Muriana, Alessandro Bandiera, Giampiero Negri, Piero Zannini, Mario Bussi
Liposarcomas are rare mesenchymal tumors that usually develop in lower extremities or retroperitoneum; cervico-mediastinal presentation is quite uncommon. These neoplasms are commonly diagnosed at a late stage because they remain asymptomatic until nearby structures are compressed. This makes radical excision particularly challenging. To date, alternative chemoradiotherapy protocols have not yet been standardized. We report a case of a 55-year-old man with a right laterocervical mass and without substantial symptoms...
December 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/29229071/branching-of-mandibular-canal-on-cone-beam-computed-tomography-images
#19
Masoomeh Afsa, Hamid Rahmati
BACKGROUND: Mandibular neurovascular canal contents may be vulnerable to damage during mandibular surgical procedures. Greater knowledge of the location and configuration of the mandibular canal can help in the safe performance of these procedures in the dental clinic. Cross-sectional CBCT imaging is a good modality for studying the course, location, configuration and accessory branches of the mandibular canal. The aim of this study was to observe the branching of the mandibular canal at different segments of the mandible and mandibular tooth groups...
December 2017: Singapore Dental Journal
https://www.readbyqxmd.com/read/29225397/concurrent-oct-imaging-of-stimulus-evoked-retinal-neural-activation-and-hemodynamic-responses
#20
Taeyoon Son, Benquan Wang, Yiming Lu, Yanjun Chen, Dingcai Cao, Xincheng Yao
It is well established that major retinal diseases involve distortions of the retinal neural physiology and blood vascular structures. However, the details of distortions in retinal neurovascular coupling associated with major eye diseases are not well understood. In this study, a multi-modal optical coherence tomography (OCT) imaging system was developed to enable concurrent imaging of retinal neural activity and vascular hemodynamics. Flicker light stimulation was applied to mouse retinas to evoke retinal neural responses and hemodynamic changes...
2017: Proceedings of SPIE
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