Lindsey M Crown, Kofi A Agyeman, Wooseong Choi, Nancy Zepeda, Ege Iseri, Pooyan Pahlavan, Steven J Siegel, Charles Liu, Vasileios Christopoulos, Darrin J Lee
INTRODUCTION: Deep brain stimulation (DBS) has shown remarkable success treating neurological and psychiatric disorders including Parkinson's disease, essential tremor, dystonia, epilepsy, and obsessive-compulsive disorder. DBS is now being explored to improve cognitive and functional outcomes in other psychiatric conditions, such as those characterized by reduced N-methyl-D-aspartate (NMDA) function (i.e., schizophrenia). While DBS for movement disorders generally involves high-frequency (>100 Hz) stimulation, there is evidence that low-frequency stimulation may have beneficial and persisting effects when applied to cognitive brain networks...
2024: Frontiers in Neuroscience