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https://www.readbyqxmd.com/read/28805687/a-review-of-the-antiviral-role-of-green-tea-catechins
#1
REVIEW
Jun Xu, Zhao Xu, Wenming Zheng
Over the centuries, infectious diseases caused by viruses have seriously threatened human health globally. Viruses are responsible not only for acute infections but also many chronic infectious diseases. To prevent diseases caused by viruses, the discovery of effective antiviral drugs, in addition to vaccine development, is important. Green tea catechins (GTCs) are polyphenolic compounds from the leaves of Camelliasinensis. In recent decades, GTCs have been reported to provide various health benefits against numerous diseases...
August 12, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28805683/analysis-and-comparison-of-the-antioxidant-component-of-portulaca-oleracea-leaves-obtained-by-different-solid-liquid-extraction-techniques
#2
Monica Gallo, Esterina Conte, Daniele Naviglio
Portulaca oleracea is a wild plant pest of orchards and gardens, but is also an edible vegetable rich in beneficial nutrients. It possesses many antioxidant properties due to the high content of vitamins, minerals, omega-3 essential fatty acids and other healthful compounds; therefore, the intake of purslane and/or its bioactive compounds could help to improve the health and function of the whole human organism. Accordingly, in this work it was analyzed and compared to the extractive capacity of the antioxidant component of purslane leaves obtained by solid-liquid extraction techniques such as: hot-maceration, maceration with ultrasound, rapid solid-liquid dynamic extraction using the Naviglio extractor, and a combination of two techniques (mix extraction)...
August 12, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28805446/epigallocatechin-gallate-as-an-anti-obesity-therapeutic-compound-an-in-silico-approach-for-structure-based-drug-designing
#3
Muhammad Shahid Javaid, Noreen Latief, Bushra Ijaz, Usman Ali Ashfaq
Epigallocatechin gallate is a polyphenol of tea plants. Other than tea its trace amounts are found in apple skin, onions and plums. It has anti-adipogenic and anti-oxidant potential. It was investigated that epigallocatechin gallate stopped the adipogenic differentiation of mice mesenchymal stem cells but its underlying mechanism is not well understood. Different proteins and transcription factors responsible for differentiation of adipocytes could be its targets. This study was designed to determine the potential target of epigallocatechin gallate in human...
August 14, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28804797/bioactivities-of-alternative-protein-sources-and-their-potential-health-benefits
#4
REVIEW
A Pihlanto, P Mattila, S Mäkinen, A-M Pajari
Increasing the utilisation of plant proteins is needed to support the production of protein-rich foods that could replace animal proteins in the human diet so as to reduce the strain that intensive animal husbandry poses to the environment. Lupins, quinoa and hempseed are significant sources of energy, high quality proteins, fibre, vitamins and minerals. In addition, they contain compounds such as polyphenols and bioactive peptides that can increase the nutritional value of these plants. From the nutritional standpoint, the right combination of plant proteins can supply sufficient amounts of essential amino acids for human requirements...
August 14, 2017: Food & Function
https://www.readbyqxmd.com/read/28802846/effect-of-domestic-cooking-on-the-starch-digestibility-predicted-glycemic-indices-polyphenol-contents-and-alpha-amylase-inhibitory-properties-of-beans-phaseolis-vulgaris-and-breadfruit-treculia-africana
#5
E Chinedum, S Sanni, N Theressa, A Ebere
The effect of processing on starch digestibility, predicted glycemic indices (pGI), polyphenol contents and alpha amylase inhibitory properties of beans (Phaseolis vulgaris) and breadfruit (Treculia africana) was studied. Total starch ranged from 4.3 to 68.3g/100g, digestible starch ranged from 4.3 to 59.2 to 65.7g/100g for the raw and processed legumes; Resistance starch was not detected in most of the legumes except in fried breadfruit and the starches in both the raw and processed breadfruit were more rapidly digested than those from raw and cooked beans...
August 9, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28802472/complementary-and-integrative-gastroenterology
#6
REVIEW
Joshua Korzenik, Anna K Koch, Jost Langhorst
Complementary and integrative medicine is developing within gastroenterology, expanding options particularly for inflammatory bowel disease, irritable bowel syndrome, and reflux esophagitis. This article encompasses new developments in complementary integrative medicine with an emphasis on herbal therapies. Studies of potential therapies have been advancing with increasing sophistication. The best studied with the most promising results in ulcerative colitis is the use of curcumin both for the induction and maintenance of remission...
September 2017: Medical Clinics of North America
https://www.readbyqxmd.com/read/28802166/design-synthesis-and-%C3%AE-amylase-inhibitory-activity-of-novel-chromone-derivatives
#7
Parthiban Valentina, Kaliappan Ilango, Subhash Chander, Sankaranarayanan Murugesan
Quercetin is one of the naturally occurring polyphenol flavonoid predominantly known for antidiabetic activity. In the present study, by considering the structural requirements, twenty two novel chromone derivatives (5-26) as α-amylase inhibitor were designed and subsequently in silico evaluated for drug likeness behavior. Designed compounds were synthesized, characterized by spectral analysis and finally evaluated for the inhibition of α-amylase activity by in vitro assay. Tested compounds exhibited significant to weak activity with IC50 range of 12-125µM...
August 1, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/28801632/stimulation-in-primary-and-secondary-metabolism-by-elevated-carbon-dioxide-alters-green-tea-quality-in-camellia-sinensis-l
#8
Xin Li, Lan Zhang, Golam Jalal Ahammed, Zhi-Xin Li, Ji-Peng Wei, Chen Shen, Peng Yan, Li-Ping Zhang, Wen-Yan Han
Rising CO2 concentration, a driving force of climate change, is impacting global food security by affecting plant physiology. Nevertheless, the effects of elevated CO2 on primary and secondary metabolism in tea plants (Camellia sinensis L.) still remain largely unknown. Here we showed that exposure of tea plants to elevated CO2 (800 µmol mol(-1) for 24 d) remarkably improved both photosynthesis and respiration in tea leaves. Furthermore, elevated CO2 increased the concentrations of soluble sugar, starch and total carbon, but decreased the total nitrogen concentration, resulting in an increased carbon to nitrogen ratio in tea leaves...
August 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28801114/effects-of-curcumin-on-short-term-spatial-and-recognition-memory-adult-neurogenesis-and-neuroinflammation-in-a-streptozotocin-induced-rat-model-of-dementia-of-alzheimer-s-type
#9
Taysa B Bassani, Joelle M Turnes, Eric L R Moura, Jéssica M Bonato, Valentín Cóppola-Segovia, Silvio M Zanata, Rúbia M M W Oliveira, Maria A B F Vital
Curcumin is a natural polyphenol with evidence of antioxidant, anti-inflammatory and neuroprotective properties. Recent evidence also suggests that curcumin increases cognitive performance in animal models of dementia, and this effect would be related to its capacity to enhance adult neurogenesis. The aim of this study was to test the hypothesis that curcumin treatment would be able to preserve cognition by increasing neurogenesis and decreasing neuroinflammation in the model of dementia of Alzheimer's type induced by an intracerebroventricular injection of streptozotocin (ICV-STZ) in Wistar rats...
August 8, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28800757/anthelminthic-properties-of-methylene-chloride-methanol-1-1-extracts-of-two-cameroonians-medicinal-plants-on-heligmosomoides-bakeri-nematoda-heligmosomatidea
#10
Sergine Errole Ngouateu Teufack, Gertrude NMbogning Tayo, Marc Ngangout Alidou, Jeannette Yondo, Amely Frankline Djiomene, Josué Wabo Poné, Faùily Mpoame Mbida
BACKGROUND: The resistance of some medico-veterinary parasite strains as well as the unavailability and toxicity of synthetic anthelminthics on humans, animals and the impacts of their residues in the environment have pushed scientists to turn to plants with anthelminthic properties. Hence, the aim of this work was to contribute to the fight against helminths of medical and veterinary importance in general, and also to clear the environment of their free living stages. METHODS: Fresh eggs of Heligmosomoides bakeri were obtained from the faeces of experimentally infected mice...
August 11, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28800275/polyphenol-rich-fraction-of-parquetina-nigrescens-mitigates-dichlorvos-induced-cardiorenal-dysfunction-through-reduction-in-cardiac-nitrotyrosine-and-renal-p38-expressions-in-wistar-rats
#11
Ademola A Oyagbemi, Temidayo O Omobowale, Grace O Ochigbo, Ebunoluwa R Asenuga, Olufunke Eunice Ola-Davies, Temitayo O Ajibade, Adebowale B Saba, Adeolu A Adedapo
Parquetina nigrescens is commonly used to treat diseases in humans and animals in developing countries, including Nigeria. This study evaluates the effects of its polyphenol-rich fraction (prf) on dichlorvos-induced cardio- and renal toxicity. There were several factors assessed during this study, including cardiac and renal markers, serum myeloperoxidase and xanthine oxidase, and electrocardiograph (ECG) changes. The changes in electrocardiograph (ECG) were recorded. Immunohistochemistry of cardiac and renal p38 and nitrotyrosine was determined...
August 11, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28800072/phosphate-linked-silibinin-dimers-plsd-new-promising-modified-metabolites
#12
Valeria Romanucci, Raffaele Gravante, Martina Cimafonte, Cinzia Di Marino, Gilles Mailhot, Marcello Brigante, Armando Zarrelli, Giovanni Di Fabio
By exploiting the regioselective protection of the hydroxyl groups of silibinin along with the well-known phosphoramidite chemistry, we have developed an efficient strategy for the synthesis of new silibinin-modified species, which we have named Phosphate-Linked Silibinin Dimers (PLSd), in which the monomer units are linked by phosphodiester bonds. The antioxidant abilities of the new PLSd were estimated on HepG2 cells using DPPH free radical scavenging and xanthine/xanthine oxidase assays. The new phosphate-metabolites showed a higher anti-oxidant activity than the silibinin, as well as very low toxicity...
August 11, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28799519/dietary-polyphenol-intake-and-risk-of-type-2-diabetes-in-the-polish-arm-of-the-health-alcohol-and-psychosocial-factors-in-eastern-europe-hapiee-study
#13
Giuseppe Grosso, Urszula Stepaniak, Agnieszka Micek, Magdalena Kozela, Denes Stefler, Martin Bobak, Andrzej Pajak
This study aimed to test the association between dietary content of total and individual classes of polyphenols and incident cases of type 2 diabetes in Polish adults participating to the Health, Alcohol and Psychosocial factors In Eastern Europe study. At baseline, diet by 148-item FFQ and health information were collected from 5806 participants free of diabetes. Self-reported incident type 2 diabetes was ascertained at 2-4-year follow-up visit. OR and 95 % CI of type 2 diabetes comparing the various categories of polyphenol intake to the lowest one (reference category) and as 1 sd increase modelled as continuous variable were calculated by performing age-, energy-, and multivariate-adjusted logistic regression models...
July 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28799497/cannabis-phenolics-and-their-bioactivities
#14
Federica Pollastro, Alberto Minassi, Luigia Grazia Fresu
Although Cannabis sativa L. is one of the most versatile plant species with multipurpose use both as medical, alimentary source and as psychoactive abuse, its biomedical relevance focused the attention on major cannabinoids. Phytochemical characterization of cannabis highlights the presence of various non-cannabinoids constituents including flavonoids, spiroindans, dihyrostilbenes, dihydrophenanthrenes, lignanamides, steroids and alkaloids. Cannabis is a plant with high pharmacological and nutrition values, its potentialities and applications are not only circumscribed to cannabinoids biological activities, but also defined by non-cannabinoid compounds...
August 10, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28798745/commentary-dietary-polyphenols-promote-growth-of-the-gut-bacterium-akkermansia-muciniphila-and-attenuate-high-fat-diet-induced-metabolic-syndrome
#15
COMMENT
https://www.readbyqxmd.com/read/28798484/epigallocatechin-3-gallate-inhibits-h2o2-induced-apoptosis-in-mouse-vascular-smooth-muscle-cells-via-67kd-laminin-receptor
#16
Xue Yan, Yanfei Li, Han Yu, Wei Wang, Chunyan Wu, Yang Yang, Yongjia Hu, Xiujuan Shi, Jue Li
Epigallocatechin-3-gallate (EGCG) is one of the major polyphenolic compounds present in green tea extracts and has been used as a potential drug for the treatment of numerous diseases. The present study aimed to elucidate the role and mechanism of EGCG in protecting against H2O2-induced apoptosis in mouse vascular smooth muscle cells (VSMCs). VSMCs were pretreated with various concentrations of EGCG for 2 hours prior to treatment with H2O2. Treatment with H2O2 significantly decreased the cell viability and induced apoptosis of VSMCs, which were attenuated by pretreatment with EGCG...
August 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28797675/from-the-hive-honey-a-novel-weapon-against-cancer
#17
REVIEW
Mariateresa Badolato, Gabriele Carullo, Erika Cione, Francesca Aiello, Maria Cristina Caroleo
Nowadays there is a folk medicine branch called apitherapy that aims to treat diseases with bee products, including honey. Honey has long been known for its medicinal and health promoting properties. It encloses numerous types of phytochemicals with high phenolic and flavonoid content, which contribute to its antioxidant and anti-inflammatory activities. Varieties and variants of polyphenols in honey showed antiproliferative property against several types of cancer. This review focuses on the latest discoveries about the key role of honey in different stages of carcinogenesis, initiation, proliferation and progression, both in vitro and in vivo, as well as on its adjuvant effect in cancer therapy...
August 3, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28797303/combined-antioxidant-effects-of-neem-extract-bacteria-red-blood-cells-and-lysozyme-possible-relation-to-periodontal-disease
#18
Leali Heyman, Yael Houri-Haddad, Samuel N Heyman, Isaac Ginsburg, Yossi Gleitman, Osnat Feuerstein
BACKGROUND: The common usage of chewing sticks prepared from Neem tree (Azadirachta indica) in India suggests its potential efficacy in periodontal diseases. The objective of this study is to explore the antibacterial effects of Neem leaf extract on the periodontophatic bacteria Porphyromonas gingivalis and Fusobacterium nucleatum, and its antioxidant capacities alone and in combination with bacteria and polycationic peptides that may be at the site of inflammation. METHODS: Neem leaf extract was prepared by ethanol extraction...
August 10, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28797008/resveratrol-attenuates-adriamycin-induced-focal-segmental-glomerulosclerosis-through-c3ar-c5ar-sphingosine-kinase-1-pathway
#19
Guoyong Liu, Qiang Wang, Yan Shi, Xiaofei Peng, Hong Liu, Youming Peng, Liyu He
BACKGROUND/AIM: Focal segmental glomerulosclerosis (FSGS) typically presents with nephrotic range proteinuria, which could eventually develop into end-stage renal disease. Resveratrol (RSV) is a natural polyphenol compound, which has been reported to suppress inflammatory response and renal interstitial fibrosis. This study is aimed at evaluating the renoprotective effect of RSV treatment on adriamycin-induced FSGS. METHODS: In Balb/c mice, adriamycin nephropathy was induced by adriamycin (10 mg/kg body weight, diluted in normal saline) via a tail vein on day 0...
August 11, 2017: Pharmacology
https://www.readbyqxmd.com/read/28796948/identification-of-polyphenol-specific-innate-epitopes-originated-from-a-resveratrol-analogue
#20
Mai Furuhashi, Yukinori Hatasa, Sae Kawamura, Takahiro Shibata, Mitsugu Akagawa, Koji Uchida
Polyphenols have received significant attention in disease prevention due to their unique chemical and biological properties. However, the underlying molecular mechanism for their beneficial effects remains unclear. We have now identified a polyphenol as a source of innate epitopes detected in natural IgM and established a unique gain-of-function mechanism in the formation of innate epitopes by polyphenol via the polymerization of proteins. Upon incubation with bovine serum albumin (BSA) under physiological conditions, several polyphenols converted the protein into the innate epitopes recognized by the IgM antibodies...
August 10, 2017: Biochemistry
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