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https://www.readbyqxmd.com/read/27676153/inhibition-of-hepatobiliary-transport-activity-by-the-antibacterial-agent-fusidic-acid-insights-into-factors-contributing-to-conjugated-hyperbilirubinemia-cholestasis
#1
Kimberly Lapham, Jonathan Novak, Lisa D Marroquin, Rachel Swiss, Shuzhen Qin, Christopher J Strock, Renato Scialis, Michael D Aleo, Thomas Schroeter, Heather Eng, A David Rodrigues, Amit S Kalgutkar
Conjugated hyperbilirubinemia accompanied by cholestasis is a frequent side effect during chronic treatment with the antimicrobial agent fusidic acid. Previous studies from our laboratory, addressing mechanisms of musculoskeletal toxicity arising from coadministration of fusidic acid with statins, demonstrated the ability of fusidic acid to potently inhibit human organic anion transporting polypeptides OATP1B1 (IC50 = 1.6 μM) and OATP1B3 (IC50 = 2.5 μM), which are responsible for the uptake-limited clearance of statins as well as bilirubin glucuronide conjugates...
October 4, 2016: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/27606620/reconfiguring-the-ar-tif2-protein-protein-interaction-hcs-assay-in-prostate-cancer-cells-and-characterizing-the-hits-from-a-lopac-screen
#2
Ashley T Fancher, Yun Hua, Daniel P Camarco, David A Close, Christopher J Strock, Paul A Johnston
The continued activation of androgen receptor (AR) transcription and elevated expression of AR and transcriptional intermediary factor 2 (TIF2) coactivator observed in prostate cancer (CaP) recurrence and the development of castration-resistant CaP (CRPC) support a screening strategy for small-molecule inhibitors of AR-TIF2 protein-protein interactions (PPIs) to find new drug candidates. Small molecules can elicit tissue selective effects, because the cells of distinct tissues express different levels and cohorts of coregulatory proteins...
October 2016: Assay and Drug Development Technologies
https://www.readbyqxmd.com/read/27503387/identification-of-drug-drug-interactions-in-vitro-a-case-study-evaluating-the-effects-of-sofosbuvir-and-amiodarone-on-hipsc-derived-cardiomyocytes
#3
Daniel C Millard, Christopher J Strock, Coby B Carlson, Natsuyo Aoyama, Krisztina Juhasz, Tom A Goetze, Sonja Stoelzle-Feix, Nadine Becker, Niels Fertig, Craig T January, Blake D Anson, James D Ross
Drug-drug interactions pose a difficult drug safety problem, given the increasing number of individuals taking multiple medications and the relative complexity of assessing the potential for interactions. For example, sofosbuvir-based drug treatments have significantly advanced care for hepatitis C virus-infected patients, yet recent reports suggest interactions with amiodarone may cause severe symptomatic bradycardia and thus limit an otherwise extremely effective treatment. Here, we evaluated the ability of human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) to recapitulate the interaction between sofosbuvir and amiodarone in vitro, and more generally assessed the feasibility of hiPSC-CMs as a model system for drug-drug interactions...
August 7, 2016: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/26408445/surgical-approaches-to-breast-augmentation-the-transaxillary-approach
#4
REVIEW
Louis L Strock
The transaxillary approach to breast augmentation has the advantage of allowing breast implants to be placed with no incisions on the breasts. There has been a general perception of a lack of technical control compared with the inframammary approach. This article presents the transaxillary approach from the perspective of the technical control gained with the aid of an endoscope, which allows precise creation of the tissue pocket with optimal visualization. The aspects of technique that allow optimal technical control are discussed, in addition to postoperative processes that aid in stabilizing the device position and allow consistent and predictable outcomes...
October 2015: Clinics in Plastic Surgery
https://www.readbyqxmd.com/read/26371817/further-progress-in-understanding-fibrosing-mediastinitis
#5
COMMENT
Stephen B Strock, Wendi Mason, James E Loyd
No abstract text is available yet for this article.
September 15, 2015: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/26362766/flux-control-in-a-defense-pathway-in-arabidopsis-thaliana-is-robust-to-environmental-perturbations-and-controls-variation-in-adaptive-traits
#6
Carrie F Olson-Manning, Christopher F Strock, Thomas Mitchell-Olds
The connections leading from genotype to fitness are not well understood, yet they are crucial for a diverse set of disciplines. Uncovering the general properties of biochemical pathways that influence ecologically important traits is an effective way to understand these connections. Enzyme flux control (or, control over pathway output) is one such pathway property. The flux-controlling enzyme in the antiherbivory aliphatic glucosinolate pathway of Arabidopsis thaliana has majority flux control under benign greenhouse conditions and has evidence of nonneutral evolution...
September 10, 2015: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/26141673/commentary-on-transaxillary-endoscopic-breast-augmentation-with-shaped-gel-implants
#7
COMMENT
Louis L Strock
No abstract text is available yet for this article.
November 2015: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/25998596/ambulatory-glucose-profile-agp-development-of-a-common-web-based-application-to-record-and-report-continuous-glucose-monitoring-data
#8
R Mazze, E Strock, R Cuddihy, D Wesley
No abstract text is available yet for this article.
2009: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/25998595/o-0544-exenatide-once-weekly-versus-twice-daily-comparison-of-diurnal-and-postprandial-glucose-patterns-using-continuous-glucose-monitoring-and-ambulatory-glucose-profile-analysis
#9
R Mazze, E Strock, R Cuddihy, B Morgan
No abstract text is available yet for this article.
2009: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/25940591/fibrosing-mediastinitis-complicating-prior-histoplasmosis-is-associated-with-human-leukocyte-antigen-dqb1-04-02-a-case-control-study
#10
Stephen B Strock, Silvana Gaudieri, Simon Mallal, Chang Yu, Daphne Mitchell, Joy Cogan, Wendi Mason, Deborah Crowe, James E Loyd
BACKGROUND: Fibrosing mediastinitis (FM) is an idiosyncratic reaction to infection with Histoplasma capsulatum with a prevalence of 3:100,000 people infected. The rarity of post-histoplasmosis fibrosing mediastinitis (PHFM) in areas where H. capsulatum is endemic suggests that an abnormal immunological host response may be responsible for the development of fibrosis. Our group previously reported an association between subjects with PHFM and human leukocyte antigen (HLA)-A*02. We sought to confirm or extend those findings with application of high resolution HLA typing in a cohort of subjects with PHFM...
2015: BMC Infectious Diseases
https://www.readbyqxmd.com/read/25859976/high-content-screening-biosensor-assay-to-identify-disruptors-of-p53-hdm2-protein-protein-interactions
#11
Yun Hua, Christopher J Strock, Paul A Johnston
This chapter describes the implementation of the p53-hDM2 protein-protein interaction (PPI) biosensor (PPIB) HCS assay to identify disruptors of p53-hDM2 PPIs. Recombinant adenovirus expression constructs were generated bearing the individual p53-GFP and hDM2-RFP PPI partners. The N-terminal p53 transactivating domain that contains the binding site for hDM2 is expressed as a GFP fusion protein that is targeted and anchored in the nucleolus of infected cells by a nuclear localization (NLS) sequence. The p53-GFP biosensor is localized to the nucleolus to enhance and facilitate the image acquisition and analysis of the PPIs...
2015: Methods in Molecular Biology
https://www.readbyqxmd.com/read/25756365/drug-reaction-with-eosinophilia-and-systemic-symptoms-syndrome-probably-induced-by-a-lamotrigine-ginseng-drug-interaction
#12
Amy P Myers, Troy A Watson, Steven B Strock
The likelihood of a drug reaction with lamotrigine is increased by dose escalation that is too rapid or drug interactions that increase the concentration of lamotrigine. There is a well-documented interaction between valproic acid and lamotrigine in which lamotrigine levels are increased, subsequently increasing the risk of a drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome. This syndrome is characterized by fever, lymphadenopathy, diffuse maculopapular rash, multivisceral involvement, eosinophilia, and atypical lymphocytes and has a mortality rate of 10-40%...
March 2015: Pharmacotherapy
https://www.readbyqxmd.com/read/25662503/safety-and-efficacy-of-insulin-therapy-delivered-via-a-4mm-pen-needle-in-obese-patients-with-diabetes
#13
RANDOMIZED CONTROLLED TRIAL
Richard M Bergenstal, Ellie S Strock, Diana Peremislov, Michael A Gibney, Valentin Parvu, Laurence J Hirsch
OBJECTIVE: To determine whether insulin delivered via a 4-mm × 32-gauge pen needle (PN) provides equivalent glycemic control as 8-mm × 31-gauge and 12.7-mm × 29-gauge PNs in obese (body mass index ≥30) patients with diabetes. PATIENTS AND METHODS: This prospective, multicenter, randomized, open-label, 2-period, crossover, equivalence, home-based study was conducted from October 26, 2010, through May 31, 2012. After a 3-week wash-in period, eligible patients aged 18 to 80 years with a hemoglobin A1c (HbA1c) level of 5...
March 2015: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/25181412/high-content-positional-biosensor-screening-assay-for-compounds-to-prevent-or-disrupt-androgen-receptor-and-transcriptional-intermediary-factor-2-protein-protein-interactions
#14
Yun Hua, Tong Ying Shun, Christopher J Strock, Paul A Johnston
The androgen receptor-transcriptional intermediary factor 2 (AR-TIF2) positional protein-protein interaction (PPI) biosensor assay described herein combines physiologically relevant cell-based assays with the specificity of binding assays by incorporating structural information of AR and TIF2 functional domains along with intracellular targeting sequences and fluorescent reporters. Expression of the AR-red fluorescent protein (RFP) "prey" and TIF2-green fluorescent protein (GFP) "bait" components of the biosensor was directed by recombinant adenovirus constructs that expressed the ligand binding and activation function 2 surface domains of AR fused to RFP with nuclear localization and nuclear export sequences, and three α-helical LXXLL motifs from TIF2 fused to GFP and an HIV Rev nucleolar targeting sequence...
September 2014: Assay and Drug Development Technologies
https://www.readbyqxmd.com/read/24669928/decadal-trends-reveal-recent-acceleration-in-the-rate-of-recovery-from-acidification-in-the-northeastern-u-s
#15
Kristin E Strock, Sarah J Nelson, Jeffrey S Kahl, Jasmine E Saros, William H McDowell
Previous reports suggest variable trends in recovery from acidification in northeastern U.S. surface waters in response to the Clean Air Act Amendments. Here we analyze recent trends in emissions, wet deposition, and lake chemistry using long-term data from a variety of lakes in the Adirondack Mountains and New England. Sulfate concentration in wet deposition declined by more than 40% in the 2000s and sulfate concentration in lakes declined at a greater rate from 2002 to 2010 than during the 1980s or 1990s (-3...
May 6, 2014: Environmental Science & Technology
https://www.readbyqxmd.com/read/24598242/a-feasibility-study-of-a-3-day-basal-bolus-insulin-delivery-device-in-individuals-with-type-2-diabetes
#16
Julia K Mader, Leslie C Lilly, Felix Aberer, Stefan Korsatko, Ellie Strock, Roger S Mazze, Peter Damsbo, Thomas R Pieber
OBJECTIVE: This study tested the feasibility of transition from multiple daily injections (MDI) to a 3-day, basal-bolus insulin delivery device (PaQ) for type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS: Twenty MDI-treated individuals with T2D with HbA(1c) ≤9% (75 mmol/mol) were enrolled in a single-center, single-arm pilot study, lasting three 2-week periods: baseline (MDI), transition to PaQ, and PaQ therapy. Feasibility of use, glycemic control, safety, and patient satisfaction were assessed...
May 2014: Diabetes Care
https://www.readbyqxmd.com/read/23811329/toxicity-assessments-of-nonsteroidal-anti-inflammatory-drugs-in-isolated-mitochondria-rat-hepatocytes-and-zebrafish-show-good-concordance-across-chemical-classes
#17
Sashi Nadanaciva, Michael D Aleo, Christopher J Strock, Donald B Stedman, Huijun Wang, Yvonne Will
To reduce costly late-stage compound attrition, there has been an increased focus on assessing compounds in in vitro assays that predict attributes of human safety liabilities, before preclinical in vivo studies are done. Relevant questions when choosing a panel of assays for predicting toxicity are (a) whether there is general concordance in the data among the assays, and (b) whether, in a retrospective analysis, the rank order of toxicity of compounds in the assays correlates with the known safety profile of the drugs in humans...
October 15, 2013: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/23598534/diurnal-glucose-profiles-using-continuous-glucose-monitoring-to-identify-the-glucose-lowering-characteristics-of-colesevelam-hcl-welchol
#18
RANDOMIZED CONTROLLED TRIAL
Roger S Mazze, Ellie S Strock, Arlene M Monk, Matthew M Murphy, Min Xi, Richard M Bergenstal
OBJECTIVES: The study's purpose was to identify the antihyperglycemic affects of colesevelam-HCl (C-HCl) by characterizing the diurnal and postprandial glucose patterns in type 2 diabetic subjects treated concomitantly with metformin, sulfonylurea, or a combination of metformin/sulfonylurea. A secondary aim was to determine whether C-HCl significantly increased the risk of hypoglycemia. METHODS: A prospective, randomized, double-blind, placebo-controlled, crossover study employing continuous glucose monitoring (CGM) with ambulatory glucose profile (AGP) analysis was undertaken...
March 2013: Endocrine Practice
https://www.readbyqxmd.com/read/23567014/recommendations-for-standardizing-glucose-reporting-and-analysis-to-optimize-clinical-decision-making-in-diabetes-the-ambulatory-glucose-profile
#19
Richard M Bergenstal, Andrew J Ahmann, Timothy Bailey, Roy W Beck, Joan Bissen, Bruce Buckingham, Larry Deeb, Robert H Dolin, Satish K Garg, Robin Goland, Irl B Hirsch, David C Klonoff, Davida F Kruger, Glenn Matfin, Roger S Mazze, Beth A Olson, Christopher Parkin, Anne Peters, Margaret A Powers, Henry Rodriguez, Phil Southerland, Ellie S Strock, William Tamborlane, David M Wesley
Underutilization of glucose data and lack of easy and standardized glucose data collection, analysis, visualization, and guided clinical decision making are key contributors to poor glycemic control among individuals with type 1 diabetes mellitus. An expert panel of diabetes specialists, facilitated by the International Diabetes Center and sponsored by the Helmsley Charitable Trust, met in 2012 to discuss recommendations for standardizing the analysis and presentation of glucose monitoring data, with the initial focus on data derived from continuous glucose monitoring systems...
2013: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/23448694/recommendations-for-standardizing-glucose-reporting-and-analysis-to-optimize-clinical-decision-making-in-diabetes-the-ambulatory-glucose-profile-agp
#20
Richard M Bergenstal, Andrew J Ahmann, Timothy Bailey, Roy W Beck, Joan Bissen, Bruce Buckingham, Larry Deeb, Robert H Dolin, Satish K Garg, Robin Goland, Irl B Hirsch, David C Klonoff, Davida F Kruger, Glenn Matfin, Roger S Mazze, Beth A Olson, Christopher Parkin, Anne Peters, Margaret A Powers, Henry Rodriguez, Phil Southerland, Ellie S Strock, William Tamborlane, David M Wesley
Abstract Underutilization of glucose data and lack of easy and standardized glucose data collection, analysis, visualization, and guided clinical decision making are key contributors to poor glycemic control among individuals with type 1 diabetes. An expert panel of diabetes specialists, facilitated by the International Diabetes Center and sponsored by the Helmsley Charitable Trust, met in 2012 to discuss recommendations for standardization of analysis and presentation of glucose monitoring data, with the initial focus on data derived from CGM systems...
March 2013: Diabetes Technology & Therapeutics
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