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Anti-platelets

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https://www.readbyqxmd.com/read/29157825/1-6-di-o-caffeoyl-%C3%AE-d-glucopyranoside-a-natural-compound-from-callicarpa-nudiflora-hook-impairs-p2y12-and-thromboxane-a2-receptor-mediated-amplification-of-platelet-activation-and-aggregation
#1
Jianjiang Fu, Xiaocui Zhu, Wei Wang, Hong Lu, Zhoumiao Zhang, Ting Liu, Huanjun Xu, Huizheng Fu, Shuangcheng Ma, Yuehua Luo
BACKGROUND: Platelet activation and subsequent accumulation at sites of vascular injury perform a central role in thrombus formation, which is believed to be the trigger of several cardiovascular diseases, such as atherosclerosis, myocardial infarction and strokes. In this sense, the search for agents that are capable of blocking platelets aggregation has important implications for these diseases. Callicarpa nudiflora (C. nudiflora) Hook is a traditional Chinese medicine herb for eliminating stasis to subdue swelling and hemostasis...
December 1, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29156815/the-effect-of-aspirin-on-circulating-netrin-1-levels-in-humans-is-dependent-on-the-inflammatory-status-of-the-vascular-endothelium
#2
Kerry Layne, Timothy Goodman, Albert Ferro, Gabriella Passacquale
In atherosclerotic animal models, the cyclo-oxygenase (COX)-inhibitor aspirin counteracts downregulation of endothelial-derived netrin-1, thus reducing arterial inflammation. We here explored the effect of aspirin on netrin-1 in healthy subjects undergoing influenza immunisation, which is an established experimental model of inflammation-related endothelial dysfunction. Our data showed that netrin-1 undergoes reduction (-29.25% from baseline; p=0.0017) in the presence of endothelial activation (VCAM-1 rose by 9...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29149707/over-expression-of-cyclooxygenase-2-in-increased-reticulated-platelets-leads-to-aspirin-resistance-after-elective-off-pump-coronary-artery-bypass-surgery
#3
Xiaoxuan Gong, Xuezhong Wang, Zhuowen Xu, Tiantian Zhu, Qiu Zhang, Jinying Zhang, Xiaowei Wang, Chunjian Li
INTRODUCTION: Aspirin resistance (AR) has been reported to present after coronary artery bypass graft causing saphenous vein graft failure. We aimed to investigate the factors that affect the anti-platelet effect of aspirin after off-pump coronary artery bypass surgery (OPCAB). MATERIALS AND METHODS: Thirty OPCAB candidates were successively recruited. Platelet count, platelet aggregation, reticulated platelet (RP), platelets' cyclooxygenase (COX)-1 and COX-2 expressions were determined during the peri-operative period...
November 9, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/29142633/risk-factors-of-delayed-surgical-intervention-after-conservatively-treated-acute-traumatic-subdural-hematoma
#4
Hyungjoo Kwon, Kyu-Sun Choi, Hyeong-Joong Yi, Hyoung-Joon Chun, Young-Jun Lee, Dong-Won Kim
Objective: Acute subdural hematoma (ASDH) is generally considered a condition that should be managed surgically. However, some patients initially receive conservative treatment, a subset of whom require surgical intervention later. This study aimed to evaluate the predictors of delayed surgical intervention in ASDH patients who are initially managed conservatively. Methods: From January 2007 to December 2015, 842 patients diagnosed with ASDH were treated at our institution...
November 2017: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/29133056/therapeutic-potential-of-songorine-a-diterpenoid-alkaloid-of-the-genus-aconitum
#5
REVIEW
Haroon Khan, Seyed Mohammad Nabavi, Antoni Sureda, Nikolay Mehterov, Diana Gulei, Ioana Berindan-Neagoe, Hiroaki Taniguchi, Atanas G Atanasov
Alkaloids are well-studied secondary metabolites, with recent preclinical studies evidencing that many of them exhibit anti-cancer, anti-depressant, anti-nociceptive, anti-inflammatory, anti-pyretic, anti-platelet, anti-oxidant, and anti-bacterial properties. Aconitum is a genus rich of diverse alkaloids. More than 450 alkaloids have been identified in a variety of species. Songorine is a C20 diterpenoid alkaloid and 12-keto analog of napelline, isolated from Aconitum soongaricum and was associated with a heterogeneous panel of biological functions...
November 10, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29129761/are-antiplatelet-and-anticoagulants-drugs-a-risk-factor-for-bleeding-in-mild-traumatic-brain-injury
#6
Laura Uccella, Cesare Zoia, Daniele Bongetta, Paolo Gaetani, Franz Martig, Christian Candrian, Raffaele Rosso
OBJECT: facing mild traumatic brain injury (mTBI) clinicians must decide whether to perform a CT scan to detect a potential intracranial hemorrhage.Many useful guidelines have been developed for general population, but there is no general consensus about the best practice to adopt when dealing with patients on antiplatelet or anticoagulation drugs. The relatively recent introduction of new anticoagulants and second generation antiplatelet drugs poses new challenges in this field. There is no data in the literature about the relative risk of intracranial bleeding in such categories...
November 9, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29129512/thieno-2-3-b-pyridine-derivatives-are-potent-anti-platelet-drugs-inhibiting-platelet-activation-aggregation-and-showing-synergy-with-aspirin
#7
Naif K Binsaleh, Catherine A Wigley, Kathryn A Whitehead, Michelle van Rensburg, Johannes Reynisson, Lisa I Pilkington, David Barker, Sarah Jones, Nina C Dempsey-Hibbert
Drugs which inhibit platelet function are commonly used to prevent blood clot formation in patients with Acute Coronary Syndromes (ACS) or those at risk of stroke. The thieno[3,2-c]pyridine class of therapeutic agents, of which clopidogrel is the most commonly used, target the P2Y12 receptor, and are often used in combination with acetylsalicylic acid (ASA). Six thieno[2,3-b]pyridine were assessed for in vitro anti-platelet activity; all derivatives showed effects on both platelet activation and aggregation, and showed synergy with ASA...
November 7, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29127504/glycocalyx-in-atherosclerosis-relevant-endothelium-function-and-as-a-therapeutic-target
#8
REVIEW
Ronodeep Mitra, Gerard Leland O'Neil, Ian Chandler Harding, Ming Jie Cheng, Solomon Arko Mensah, Eno Essien Ebong
PURPOSE OF REVIEW: The cell surface-attached extracellular glycocalyx (GCX) layer is a major contributor to endothelial cell (EC) function and EC-dependent vascular health and is a first line of defense against vascular diseases including atherosclerosis. Here, we highlight our findings regarding three GCX-dependent EC functions, which are altered when GCX is shed and in atherosclerosis. We discuss why the GCX is a viable option for the prevention and treatment of atherosclerosis. RECENT FINDINGS: GCX regulated EC activities such as barrier and filtration function, active cell-to-cell communication, and vascular tone mediation contribute to function of the entire vascular wall...
November 10, 2017: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/29126476/high-throughput-human-plasma-n-glycan-analysis-using-dna-analyzer-and-multivariate-analysis-for-biomarker-discovery
#9
Hua-Tao Feng, Siying Lim, Anna Karen Carrasco Laserna, Pingjing Li, Xuejiao Yin, Erhan Simsek, Shaheer H Khan, Shiaw-Min Chen, Sam F Y Li
Carbohydrates form the majority of organic compounds found in nature and their presence on proteins influences many important bioactivities. Therefore, glycan profiling shows potential in clinical applications. This work demonstrates the use of a high-throughput GlycanAssure™ sample preparation technology and multi-capillary DNA analyzer for the analysis of the major N-linked glycans (N-glycans) found in human plasma. The application involves two biomarker studies: (1) in profiling patients with chronic kidney disease and (2) in differentiating heart disease patients with normal controls in response to an antiplatelet drug from hypo-responders...
December 1, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29126112/risk-scoring-to-guide-anti-platelet-therapy-post-percutaneous-coronary-intervention-pci-for-acute-coronary-syndrome-acs-results-in-improved-clinical-outcomes
#10
S Antoniou, M Colicchia, O Guttmann, K Rathod, P Wright, S Fhadil, C Knight, A K Jain, E J Smith, A Mathur, R Weerackody, A Wragg, D A Jones
Objective: To use the GRACE and CRUSADE scores to risk stratify anti-platelet treatment post Acute Coronary Syndrome (ACS). Methods: This was a prospective registry of 3374 patients undergoing PCI for ACS between 2013-2015 at a UK cardiac centre. Patients with either low GRACE or high CRUSADE risk scores were stratified to clopidogrel therapy otherwise ticagrelor was used. The primary end-point was major adverse cardiac events (MACE) defined as death, non-fatal myocardial infarction, stroke, or target vessel revascularization with bleeding rates as a secondary outcome, assessed at a median follow-up of 1...
November 8, 2017: European Heart Journal. Quality of Care & Clinical Outcomes
https://www.readbyqxmd.com/read/29119922/polyphenols-anti-platelet-nutraceutical
#11
Valeria Ludovici, Jens Barthelmes, Matthias P Nägele, Andreas J Flammer, Isabella Sudano
BACKGROUND: Coronary artery disease (CAD) is a disease progressing over many years. Genetic factors, as well as the exposure to risk factors, are continuously leading to endothelial dysfunction, vascular alterations and, eventually, organ damage, major cardiovascular events and deaths. Oxidative stress, platelet hyperactivity and low-grade inflammation are important modulators in this context, contributing to plaque formation. Since platelet activation plays a critical role in the development and progression of atherothrombotic events, the inhibition of platelet hyperactivity may contribute to decreased atherothrombotic risk...
November 8, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29107156/advantages-of-staged-angioplasty-in-a-patient-with-internal-carotid-artery-pseudo-occlusion-besides-prevention-of-cerebral-hyperperfusion-syndrome
#12
Satoshi Takahashi, Takenori Akiyama, Jin Nakahara, Takahito Yoshizaki, Norihiro Suzuki, Kazunari Yoshida
BACKGROUND: Staged angioplasty for carotid artery stenosis has been reported to be effective in preventing postoperative cerebral hyperperfusion syndrome (CHS) in patients with severe carotid stenosis; thus, it is also recommended for patients with internal carotid artery (ICA) pseudo-occlusion, the treatment strategy for which is controversial. CASE DESCRIPTION: This study reports the case of an Asian male in his 50s who suffered from motor aphasia and right-side weakness due to pseudo-occlusion of the left ICA...
October 26, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29096904/-stent-thrombosis-what-s-up-in-2017
#13
R Kallel, R Hakim, G Rangé
Stent thrombosis (ST) is still a dreadful and threatening complication of percutaneous coronary intervention (PCI) with a high risk of morbi-mortality. Nevertheless, it becomes exceptional (0.6% at 1 year and 0.15%/year later) thanks to improvement of stents and use of new P2Y12 inhibitors. Endo-coronary imaging and especially Optical Coherence Tomography (OCT) change radically its understanding with revealing quiet systematic morphologic endoluminal abnormalities (97% of the cases). OCT becomes an essential tool in practice (ESC recommendation class IIa) and allows a therapeutic strategy optimization...
October 30, 2017: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/29092117/a-staged-approach-of-proximal-left-anterior-descending-coronary-artery-percutaneous-intervention-followed-by-minimally-invasive-valve-surgery
#14
Andrés M Pineda, Christos G Mihos, Juan P Rodriguez-Escudero, Joseph Lamelas, Nirat Beohar, Orlando Santana
BACKGROUND: A subset of patients requiring coronary revascularization of the proximal left anterior descending coronary artery (LAD) and valve surgery may benefit from a staged approach, rather than combined median sternotomy coronary artery bypass graft (CABG) and valve surgery. METHODS: A retrospective evaluation was made of the outcomes of patients with significant proximal LAD and valvular heart disease undergoing a staged approach of percutaneous coronary intervention (PCI) followed by minimally invasive valve surgery (MIVS) at the authors' institution between February 2009 and April 2014...
May 2017: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/29089752/beta-blocker-under-use-in-copd-patients
#15
Kuan Pin Lim, Sarah Loughrey, Michael Musk, Melanie Lavender, Jeremy P Wrobel
BACKGROUND: Cardiovascular (CVS) comorbidities are common in COPD and contribute significantly to morbidity and mortality, especially following acute exacerbations of COPD (AECOPD). Beta-blockers (BBs) are safe and effective in COPD patients, with demonstrated survival benefit following myocardial infarction. We sought to determine if BBs are under-prescribed in patients hospitalized with AECOPD. We also sought to determine inpatient rates of CVS and cerebrovascular complications, and their impact on patient outcomes...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29071968/-clinical-trials-for-treatment-of-stroke-patients-with-dysphagia-by-vitalstim-electroacupuncture-combined-with-swallowing-rehabilitation-training
#16
Sheng-Yu Zhang, Shao-Bing Liu, Wei Wu, Yi-Min Chen, Kang-Lin Liao, Yong Xiang, Dun Pan
OBJECTIVE: To observe the clinical effect of vitalstim electroacupuncture (EA) combined with swallowing rehabilitation training in the treatment of stroke patients with dysphagia. METHODS: A total of 80 stroke patients with dysphagia were randomized into treatment and control groups (n=40 in each group). Patients of the control group were treated by regular medication for anti-platelet aggregation and anti-coagulation, lipid-lowering, neuroprotection, blood glucose control and blood pressure control, etc...
April 25, 2017: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29071332/effect-of-chewing-vs-swallowing-ticagrelor-on-platelet-inhibition-in-patients-with-st-segment-elevation-myocardial-infarction-a-randomized-clinical-trial
#17
Elad Asher, Shir Tal, Israel Mazin, Arsalan Abu-Much, Avi Sabbag, Moshe Katz, Ehud Regev, Fernando Chernomordik, Victor Guetta, Amit Segev, Dan Elian, Israel Barbash, Paul Fefer, Michael Narodistky, Roy Beigel, Shlomi Matetzky
Importance: Dual anti-platelet therapy represents standard care for treating patients with ST-segment elevation myocardial infarction (STEMI). Ticagrelor is a direct-acting P2Y12 inhibitor and, unlike clopidogrel and prasugrel, does not require metabolic activation. Objective: To evaluate whether chewing a loading dose (LD) of ticagrelor, 180 mg, vs traditional oral administration of an equal dose enhances platelet inhibition at 30 minutes and 1 hour after LD administration in patients with STEMI...
October 25, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/29051102/isolation-structural-characterization-and-bioactivities-of-naturally-occurring-polysaccharide-polyphenolic-conjugates-from-medicinal-plants-a-reivew
#18
REVIEW
Jun Liu, Ruyu Bai, Yunpeng Liu, Xin Zhang, Juan Kan, Changhai Jin
In recent years, several medicinal plants have been demonstrated as valuable resources of naturally occurring polysaccharide-polyphenolic conjugates. For the first time, this article introduces recent advances of polysaccharide-polyphenolic conjugates isolated from different medicinal plants. The isolation, purification, structural characterization and biological activities of polysaccharide-polyphenolic conjugates are introduced in details. In general, polysaccharide-polyphenolic conjugates can be isolated by hot water or alkaline extraction followed by purification through anion exchange chromatography or gel filtration chromatography...
October 16, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29051021/anti-pdgfra-antibodies-predict-for-response-to-nilotinib-in-steroid-refractory-dependent-cgvhd
#19
George L Chen, Paul A Carpenter, Raewyn Broady, Tara K Gregory, Laura J Johnston, Barry E Storer, Jan H Beumer, Jingxin Qiu, Kiara Cerda, Ryan Le, Joanne M Otani, Hong Liu, Maureen A Ross, Sally Arai, Mary E D Flowers, Philip L McCarthy, David B Miklos
Imatinib has clinical activity in chronic graft-versus-host disease (cGvHD), a significant complication of allogeneic hematopoietic cell transplant. Nilotinib is a tyrosine kinase inhibitor that targets the same receptors as imatinib but with different affinities. We tested the hypothesis that nilotinib is safe and has clinical activity in cGvHD. 33 participants were enrolled in a phase 1/2 dose escalation and dose extension clinical trial of nilotinib for the treatment of steroid refractory or dependent cGvHD (ClinicalTrials...
October 16, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29050464/anti-platelet-effects-of-epigallocatechin-3-gallate-in-addition-to-the-concomitant-aspirin-clopidogrel-or-ticagrelor-treatment
#20
Hyung Joon Joo, Ji-Young Park, Soon Jun Hong, Kyoung-Ah Kim, Seung Hoon Lee, Jae-Young Cho, Jae Hyoung Park, Cheol Woong Yu, Do-Sun Lim
Background/Aims: Although epigallocatechin-3-gallate (EGCG), which is found in high contents in the dried leaves of green tea, has been reported to have an anti-platelet effect, synergistic effects of EGCG in addition to current anti-platelet medications remains to be elucidated. Methods: Blood samples were obtained from 40 participants who took aspirin (ASA, n = 10), clopidogrel (CPD, n = 10), ticagrelor (TCG, n = 10) and no anti-platelet medication (Control, n = 10)...
October 19, 2017: Korean Journal of Internal Medicine
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