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https://www.readbyqxmd.com/read/29777984/lc-ms-analysis-to-determine-the-biodistribution-of-a-polymer-coated-ilomastat-ocular-implant
#1
Abeer H A Mohamed-Ahmed, Alastair Lockwood, Hala Fadda, Shivam Madaan, Peng T Khaw, Steve Brocchini, Kersti Karu
Ilomastat is a matrix metalloproteinase inhibitor (MMPi) that has shown the potential to inhibit scarring (fibrosis) by mediating healing after injury or surgery. A long lasting ocular implantable pharmaceutical formulation of ilomastat is being developed to mediate the healing process to prevent scarring after glaucoma filtration surgery. The ilomastat implant was coated with water permeable and biocompatible phosphoryl choline polymer (PC1059) displayed extended slow release of ilomastat in vitro and in vivo...
May 16, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29766644/evaluation-of-the-influence-of-implant-placement-timing-on-the-esthetic-outcomes-of-single-tooth-implant-treatment-in-the-anterior-maxilla-a-retrospective-study
#2
Himanshu Arora, Saso Ivanovski
OBJECTIVES: The purpose of this retrospective study was to investigate the influence of implant placement timing on the esthetic outcomes for single implants in the anterior maxilla. MATERIALS AND METHODS: One hundred and ten patients (48 males; 62 females) who received a single-tooth implant after extraction either immediately (Type 1); after 4-8 weeks (Type 2); after 8-16 weeks (Type 3); or more than 16 weeks (Type 4) were evaluated in terms of esthetic outcomes after a mean post-placement interval of 26...
May 15, 2018: Journal of Esthetic and Restorative Dentistry
https://www.readbyqxmd.com/read/29746546/transcatheter-aortic-valve-implantation-for-aortic-stenosis-in-high-surgical-risk-patients-a-systematic-review-and-meta-analysis
#3
Zulian Liu, Elaine Kidney, Danai Bem, George Bramley, Susan Bayliss, Mark A de Belder, Carole Cummins, Rui Duarte
BACKGROUND: Symptomatic aortic stenosis has a poor prognosis. Many patients are considered inoperable or at high surgical risk for surgical aortic valve replacement (SAVR), reflecting their age, comorbidities and frailty. The clinical effectiveness and safety of TAVI have not been reviewed systematically for these high levels of surgical risk. This systematic review compares mortality and other important clinical outcomes up to 5 years post treatment following TAVI or other treatment in these risk groups...
2018: PloS One
https://www.readbyqxmd.com/read/29738592/treatment-of-corneal-ectasia-by-implantation-of-an-allogenic-corneal-lenticule
#4
Meiyan Li, Feng Zhao, Meng Li, Michael C Knorz, Xingtao Zhou
PURPOSE: To describe a case in which post-LASIK corneal ectasia was treated using an allogeneic lenticule implanted into the recipient eye. METHODS: A 29-year-old man presented with bilateral ectasia 10 years after LASIK. Manifest refraction was -1.50 -3.25 × 15° in the right eye and -13.50 -6.00 × 10° in the left eye. Because of contact lens intolerance in the left eye, the authors decided to implant an allogenic corneal lenticule, created by small incision lenticule extraction with the VisuMax laser (Carl Zeiss Meditec, Jena, Germany) in a donor eye with a refraction of +5...
May 1, 2018: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/29732018/immediate-functional-loading-of-single-implants-a-multicenter-study-with-4-years-of-follow-up
#5
Filiep Raes, Tammaro Eccellente, Carolina Lenzi, Michele Ortolani, Giuseppe Luongo, Carlo Mangano, Francesco Mangano
Background. In the current scientific literature there are only few studies on the immediate functional loading of single implants. The aim of the present present study was to evaluate the 4-year survival rate, complication rate and peri-implant marginal bone loss (PIMBL) of immediately loaded single implants inserted in healed ridges and fresh post-extraction sites. Methods. Six centers were involved in this prospective study. The surgical and prosthetic protocol was defined in detail, before the start of recruiting patients...
2018: Journal of Dental Research, Dental Clinics, Dental Prospects
https://www.readbyqxmd.com/read/29719439/factors-affecting-radiotherapy-prescribing-patterns-in-the-post-mastectomy-setting
#6
T A Koulis, A Dang, C Speers, R A Olson
Background: Radiation therapy (rt) after mastectomy for breast cancer can improve survival outcomes, but has been associated with inferior cosmesis after breast reconstruction. In the literature, rt dose and fractionation schedules are inconsistently reported. We sought to determine the pattern of rt prescribing practices in a provincial rt program for patients treated with mastectomy and reconstruction. Methods: Women diagnosed with stages 0-iii breast cancer between January 2012 and December 2013 and treated with curative-intent rt were identified from a clinicopathology database...
April 2018: Current Oncology
https://www.readbyqxmd.com/read/29682255/effectiveness-of-computer-assisted-anesthetic-delivery-system-sta-%C3%A2-in-dental-implant-surgery-a-prospective-study
#7
F R Grassi, B Rapone, F Scarano Catanzaro, M Corsalini, Z Kalemaj
Objectives: This prospective cohort study aimed to investigate effectiveness of Computerized Local Anesthesia (CLA) on oral implantology through estimation of pain and discomfort and total quantity of injected anesthetic. Methods: Forty-five consecutive patients whose treatment plan included immediate or late dental implants were included in this study. The main inclusion criteria comprised: previous implant intervention under conventional anesthesia (CA) during the past 3 years and no previous treatment of pain relief...
October 2017: Oral & Implantology
https://www.readbyqxmd.com/read/29675379/photorefractive-keratectomy-after-cataract-surgery-in-uncommon-cases-long-term-results
#8
Anna Maria Roszkowska, Mario Urso, Giuseppe Alberto Signorino, Leopoldo Spadea, Pasquale Aragona
AIM: To evaluate the efficacy and safety of the excimer laser correction of the residual refractive errors after cataract extraction with intraocular lens (IOL) implantation in uncommon cases. METHODS: Totally 24 patients with high residual refractive error after cataract surgery with IOL implantation were examined. Twenty-two patients had a history of phacoemulsification and IOL implantation, and two had extra-capsular cataract extraction with IOL implantation...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29575589/clinical-and-esthetic-outcome-with-immediate-insertion-and-provisionalization-with-or-without-connective-tissue-grafting-in-presence-of-mucogingival-recessions-a-retrospective-analysis-with-follow-up-between-1-and-8-years
#9
Robert Noelken, Maximilian Moergel, Tobias Pausch, Martin Kunkel, Wilfried Wagner
BACKGROUND: Recessions following immediate implant insertion are frequently reported in the literature. Data regarding implant installation in presence of mucogingival recessions are rare. PURPOSE: This study observes soft tissue level changes following immediate implant insertion and provisionalization of implants with or without connective tissue grafts in the anterior maxilla in patients with initial mucogingival recession within a follow-up period between one and eight years...
March 24, 2018: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/29569817/in-vitro-and-in-vivo-evaluation-of-novel-biodegradable-mg-ag-y-alloys-for-use-as-resorbable-bone-fixation-implant
#10
Kun Yu, Yilong Dai, Zhongwei Luo, Haitao Long, Min Zeng, Zhaohui Li, Jianxi Zhu, Liang Cheng, Yu Zhang, Hui Liu, Yong Zhu
Magnesium (Mg) alloy is gaining more interest because of its degradability and osteogenic potential. Still, it has some deficiencies, such as its rapid degradation rate, insufficient mechanical property. This research aimed to design a novel biodegradable Mg-Argentum (Ag)- Yttrium (Y) alloy, and Y was added to improve degradable and mechanical property. Mg-Ag-Y alloys were characterized for mechanical features, practicabilities in vitro and in vivo. The mechanical features results shown that this novel component was similar to native bone tissue in elastic moduli, tensile and compressive stress...
March 23, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29569331/mesenchymal-stem-cell-seeded-biomimetic-3d-printed-scaffolds-induce-complete-bridging-of-femoral-critical-sized-defects
#11
John A Szivek, David A Gonzales, Andrew M Wojtanowski, Michael A Martinez, Jordan L Smith
No current clinical treatments provide an ideal long-term solution for repair of long bone segment defects. Incomplete healing prevents patients from returning to preinjury activity and ultimately requires additional surgery to induce healing. Obtaining autologous graft material is costly, incurs morbidity, requires surgical time, and quality material is finite. In this pilot study, 3D printed biomimetic scaffolds were used to facilitate rapid bone bridging in critical sized defects in a sheep model. An inverse trabecular pattern based on micro-CT scans of sheep trabecular bone was printed in polybutylene terephthalate...
March 23, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29541691/acute-primary-angle-closure-in-sturge-weber-syndrome
#12
Wei-Wen Su
Purpose: Sturge-Weber syndrome (SWS) is a neurocutaneous disorder characterized by facial cutaneous venous dilatation (port-wine stain), leptomeningeal angioma, and ocular abnormalities. Here we report a case of SWS who experienced acute primary angle-closure in the same side of the nevus flammeus. Observations: A 64-years-old female patient with SWS port wine stain on the left side of her face was referred to our ER for acute primary angle-closure (PAC). The IOP was 64 mmHg in the left eye (12 mmHg in OD) and the visual acuity was 20/100...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29534133/tissue-dimensional-changes-in-single-tooth-immediate-extraction-implant-placement-in-the-esthetic-zone-a-retrospective-clinical-study
#13
Francesco Amato, Giorgio Polara, Giorgio Alfredo Spedicato
PURPOSE: The aim of this study was to evaluate the buccopalatal volumetric tissue change that occurs following flapless single-tooth immediate extraction placement in the esthetic area and to analyze the role of four different variables. MATERIALS AND METHODS: Patients in need of a single-tooth replacement in the anterior maxillary or mandibular area (premolar to premolar) were recruited for the study. Patients were treated using four different therapeutic modalities: group 1 (healing abutment), group 2 (healing abutment + bone graft), group 3 (provisional restoration), and group 4 (provisional + bone graft)...
March 2018: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/29526508/risk-factors-associated-with-post-loading-implant-loss-of-removable-and-fixed-implant-supported-prostheses-in-edentulous-jaws
#14
Makiko Takashima, Yoshiaki Arai, Atsushi Kawamura, Katsumi Uoshima
PURPOSE: This study analyzed risk factors for post-loading implant loss in cases of implant-supported prostheses applied to edentulous jaws of Japanese patients. METHODS: In total, 245 dental implant fixtures placed in 54 edentulous jaws of 46 patients performed at Niigata University Hospital were retrospectively analyzed. Kaplan-Meier curves were used to estimate the cumulative survival rate (SR) of implants, and multiple Cox regression analysis was used to identify predictive factors of implant loss...
March 8, 2018: Journal of Prosthodontic Research
https://www.readbyqxmd.com/read/29523381/iatrogenic-trigeminal-post-traumatic-neuropathy-a-retrospective-two-year-cohort-study
#15
Y Klazen, F Van der Cruyssen, M Vranckx, M Van Vlierberghe, C Politis, T Renton, R Jacobs
With the growing demand for dental work, trigeminal nerve injuries are increasingly common. This retrospective cohort study examined 53 cases of iatrogenic trigeminal nerve injury seen at the Department of Oral and Maxillofacial Surgery, University Hospitals of Leuven between 2013 and 2014 (0.6% among 8845 new patient visits). Patient records were screened for post-traumatic trigeminal nerve neuropathy caused by nerve injury incurred during implant surgery, endodontic treatment, local anaesthesia, tooth extraction, or specifically third molar removal...
June 2018: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29520950/early-intervention-of-peri-implantitis-and-periodontitis-utilizing-a-mouse-model
#16
Ryan L Wong, Sarah Hiyari, Aline Yaghsezian, Mina Davar, Maísa Casarin, Yi-Ling Lin, Sotirios Tetradis, Paulo M Camargo, Flavia Q Pirih
BACKGROUND: Peri-implantitis is an inflammatory response to bacterial biofilm resulting in bone loss and can ultimately lead to implant failure. Due to the lack of predictable treatments available, a thorough understanding of peri-implantitis's pathogenesis is essential. The objective of this study is to evaluate and compare the response of acute induced peri-implantitis and periodontitis lesions after insult removal. METHODS: Implants were placed in one-month-old C57BL/6J male mice eight weeks post extraction of their left maxillary molars...
February 19, 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/29501643/use-of-an-automated-suture-fastening-device-in-minimally-invasive-aortic-valve-replacement
#17
Tyler J Beute, Matthew D Orem, Timothy M Schiller, Matthew Goehler, Jessica Parker, Charles L Willekes, Tomasz Timek
BACKGROUND: Minimally invasive aortic valve replacement (mAVR) is gaining clinical acceptance, however, it is associated with increased operative times due to limited surgical field and access. The Cor-Knot is an automated fastening device designed to facilitate suture fastening, but clinical data in mAVR are lacking. METHODS: From May 2014 to February 2017, 92 patients underwent mAVR at our center with 39 valves secured with manually-tied (MT) sutures and 53 valves entirely secured with the Cor-Knot (CK)...
March 1, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29496317/the-effect-of-time-to-post-operative-weightbearing-on-functional-and-clinical-outcomes-in-adults-with-a-displaced-intra-articular-calcaneal-fracture-a-systematic-review-and-pooled-analysis
#18
REVIEW
A Siebe De Boer, Esther M M Van Lieshout, Gerson Van Moolenbroek, Dennis Den Hartog, Michael H J Verhofstad
BACKGROUND: Post-operative weightbearing guidelines for displaced intra-articular calcaneal fractures (DIACF) have been pragmatically developed in the past, however hardly adapted to current health care insights. A period of six to nine weeks of non-weightbearing is usually recommended. It is unknown whether an earlier start of weightbearing is advisable. OBJECTIVES: The primary aim was to evaluate the effect of time to post-operative weightbearing on Böhler's angle...
April 2018: Injury
https://www.readbyqxmd.com/read/29490387/-vascular-outlining-augmented-imaging-for-transfemoral-access-a-preclinical-investigation
#19
Kaveh Eghbalzadeh, Elmar W Kuhn, Anton Sabashnikov, Carolyn Weber, Cherif Sahyoun, Tanja Rudolph, Stephan Baldus, Thorsten C W Wahlers, Navid Mader
BACKGROUND:  Advanced visualization software tools have been used in clinics to improve the safety and accuracy of transcatheter procedure. Imaging techniques have greatly evolved during the era of transcatheter aortic valve implantation (TAVI). In a retrospective analysis, we investigated the feasibility of augmented fluoroscopy for iliofemoral access using a novel "Vascular Outlining" roadmapping technology. METHODS:  The Vascular Outlining prototype device (Philips Healthcare) application was used with iliofemoral angiography of 10 patients undergoing transfemoral TAVI...
February 28, 2018: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/29489026/application-of-seminal-plasma-to-female-genital-tract-prior-to-embryo-transfer-in-assisted-reproductive-technology-cycles-ivf-icsi-and-frozen-embryo-transfer
#20
REVIEW
Baris Ata, Ahmed M Abou-Setta, Ayse Seyhan, William Buckett
BACKGROUND: The female genital tract is not exposed to seminal plasma during standard assisted reproductive technology (ART) cycles. However, it is thought that the inflammatory reaction triggered by seminal plasma may be beneficial by inducing maternal tolerance to paternal antigens expressed by the products of conception, and may increase the chance of successful implantation and live birth. OBJECTIVES: To assess the effectiveness and safety of application of seminal plasma to the female genital tract prior to embryo transfer in ART cycles...
February 28, 2018: Cochrane Database of Systematic Reviews
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