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https://www.readbyqxmd.com/read/29789606/the-prognostic-value-of-systemic-inflammation-in-patients-undergoing-surgery-for-colon-cancer-comparison-of-composite-ratios-and-cumulative-scores
#1
Ross D Dolan, Stephen T McSorley, James H Park, David G Watt, Campbell S Roxburgh, Paul G Horgan, Donald C McMillan
INTRODUCTION: The systemic inflammatory response has been proven to have a prognostic value. There are two methods of assessing the systemic inflammatory response composite ratios (R) and cumulative scores (S). The aim of this study was to compare the prognostic value of ratios and scores in patients undergoing surgery for colon cancer. METHODS: Patients were identified prospectively in a single surgical unit. Preoperative neutrophil (N), lymphocyte (L), monocyte (M) and platelet (P) counts, CRP (C) and albumin (A) levels were recorded...
May 23, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29789534/the-novel-klf4-plac8-signaling-pathway-regulates-lung-cancer-growth
#2
Yunlu Jia, Xiaogang Ying, Jichun Zhou, Yongxia Chen, Xiao Luo, Shudu Xie, Qin Chuan Wang, Wenxian Hu, Linbo Wang
Accumulating evidence suggests that placenta-specific 8 (PLAC8) plays an important role in normal cellular process and human diseases, including multiple types of human tumors, and its role is highly relied upon in cellular and physiologic contexts. However, there are no reports on its expression profile and biological roles during lung cancer development. In the current study, both the clinical implications and biological effects of PLAC8 in lung cancer (LC) progression were investigated, and we identified and described the novel Krüppel-like factor 4 (KLF4)/PLAC8 regulatory pathway in cancer progression...
May 22, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29788086/prognostic-ability-of-new-t1-descriptors-in-the-tumour-node-and-metastasis-classification-of-surgically-treated-non-small-cell-lung-cancer
#3
Tomoyoshi Takenaka, Koji Yamazaki, Naoko Miura, Sadanori Takeo
OBJECTIVES: In the tumour, node and metastasis (TNM) classification (8th edition) of non-small-cell lung cancer, T (tumour size) is determined solely according to the size of the solid component determined using computed tomography (CT). However, it is unclear whether tumours of equal size but with differing solid and part-solid components should be similarly treated. Herein, we assessed the prognostic significance of the newly proposed T1 descriptors with respect to the size of the solid component...
May 19, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29786691/prognosis-and-nomogram-for-predicting-postoperative-survival-of-duodenal-adenocarcinoma-a-retrospective-study-in-china-and-the-seer-database
#4
Sujing Jiang, Rongjie Zhao, Yiran Li, Xufeng Han, Zhen Liu, Weiting Ge, Ying Dong, Weidong Han
As primary duodenal adenocarcinoma is rare, the prognostic factors of this disease remain insufficiently explored, especially in China. We identified postoperative duodenal adenocarcinoma patients at a Chinese double-center (from 2006 to 2016) or who were registered with the Surveillance, Epidemiology, and End Results (SEER) database (from 2004 to 2014). Clinicopathological features and significant prognostic factors for cancer-specific survival (CSS) were reviewed and analyzed by using univariate and multivariate Cox proportional hazards regression...
May 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29785842/circular-rna-0068669-as-a-new-biomarker-for-hepatocellular-carcinoma-metastasis
#5
Ting Yao, Qingqing Chen, Zhouwei Shao, Zhihua Song, Liyun Fu, Bingxiu Xiao
BACKGROUND: Circular RNAs (circRNAs) play important roles in disease occurrence. However, the roles of circRNAs in the diagnosis of hepatocellular carcinoma (HCC) are largely unknown. The aim of this study is to investigate the clinical diagnostic values of hsa_circ_0068669 (Alias: hsa_circ_103561), one of the representative HCC-associated circRNAs. METHODS: Hsa_circ_0068669 expression levels in HCC tissues, HCC cell lines, and chronic hepatitis tissues were detected by real-time quantitative reverse transcription-polymerase chain reaction...
May 21, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29785165/thymic-carcinoma-a-rare-case-report
#6
Nidhi Bansal, Arnav Kr Roychoudhury, Harshi Dhingra
Introduction: Thymic carcinoma is a rare, invasive mediastinal neoplasm with a tendency to metastasize. They constitute a heterogeneous group of tumors that present differently in terms of both behavior and prognosis. Case report: We present a case of thymic carcinoma in a 55-year-old male patient known to suffer from Myasthenia gravis, whose chief complaints were fatigability, ptosis and coughing. All electromyography studies were done along with excision biopsy to reach the definitive diagnosis...
2018: Clujul Medical (1957)
https://www.readbyqxmd.com/read/29784506/predicting-prognosis-in-resected-esophageal-squamous-cell-carcinoma-using-a-clinical-nomogram-and-recursive-partitioning-analysis
#7
Yuzhen Zheng, Shenshen Fu, Tiancheng He, Qihang Yan, Wenyu Di, Junye Wang
BACKGROUND: Development demand of precise medicine in resectable esophageal squamous cell carcinoma (ESCC) require to recognize patients at high risk treated by surgery alone. Thus, our aim was to construct a clinical nomogram and recursive partitioning analysis (RPA) to predict long-term survival in ESCC treated by surgery alone. METHODS: Based on the patients with ESCC who treated by three-incisional esophagectomy and two-field lymphadenectomy alone, we identified and integrated significant prognostic factors for survival to build a nomogram...
April 24, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29781037/microrna-485-plays-tumour-suppressive-roles-in-colorectal-cancer-by-directly-targeting-gab2
#8
Jibin Li, Jian Xu, Xiaofei Yan, Keer Jin, Wenya Li, Rui Zhang
Colorectal cancer (CRC) is reported to be the third most common cancer and the fourth leading cause of cancer-related deaths around the world. MicroRNA-485 (miR-485) has been reported to be aberrantly expressed and play important roles in several types of human malignancy. However, the expression level, biological functions and underlying molecular mechanisms of miR-485 in CRC remain unclear. Therefore, the aim of the present study was to determine miR-485 expression levels and their clinical significance in CRC and to explore the functions and underlying mechanisms of miR-485 in this disease...
May 17, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29778540/the-clinicopathological-and-prognostic-value-of-long-non-coding-rna-zeb1-as1-in-solid-tumors-a-meta-analysis
#9
REVIEW
Chaojie Liang, Jing Liu, Hua Ge, Yingchen Xu, Guangming Li, Jixiang Wu
BACKGROUND AND AIM: Studies have reported that Zinc finger E-box binding homeobox 1 antisense 1 (ZEB1-AS1) is overexpressed in many malignant tumors. However, the sample size in those studies was limited, so the clinicopathological and prognostic value of ZEB1-AS1 in solid tumors remains undetermined, Accordingly, the aim of this meta-analysis was to evaluate the relationship between the expression of lncRNA ZEB1-AS1 and clinicopathological characteristics and prognosis in patients with solid tumors...
May 17, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29778424/nrage-confers-poor-prognosis-and-promotes-proliferation-invasion-and-chemoresistance-in-gastric-cancer
#10
Xiaodi Jiang, Xiaofeng Jiang, Zhi Yang
Neurotrophin receptor-interacting melanoma antigen-encoding protein (NRAGE) is a type II melanoma-associated antigen that plays an essential role in various processes, including cell differentiation and apoptosis. NRAGE has been shown to act as a cancer-related protein, with complex and apparently contradictory functions in a variety of cancers. In the current study, we examined the expression of NRAGE protein in 169 gastric cancer samples. NRAGE upregulation was correlated with advanced TNM stage, local invasion, and poor survival...
May 17, 2018: Gene
https://www.readbyqxmd.com/read/29775980/-comparison-of-the-masaoka-koga-classification-with-the-new-tnm-staging-of-the-iaslc-itmig-for-thymoma-and-thymic-carcinoma
#11
Michael Ried, Maria-Magdalena Eicher, Reiner Neu, Dietmar Kraus, Sebastian Inderhees, Alexander Marx, Hans-Stefan Hofmann
BACKGROUND: The Masaoka-Koga classification describes the extent and spread of thymic epithelial malignancies. The objective of this study was to evaluate the Masaoka-Koga and the new TNM-staging system regarding differences in stage distributions, clinical implementation and therapeutic consequences. METHODS: Retrospective analysis of all patients who underwent surgery between January 2005 and December 2015 for thymoma/thymic carcinoma in two centres for thoracic surgery...
May 18, 2018: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/29774993/-preliminary-study-on-the-expression-of-egfrv%C3%A2-and-cxcr4-in-head-and-neck-squamous-cell-carcinoma
#12
H D Zhang, S C Gong, Y Q Liu, S B He, Q X Zhang, M Y Si, Z K Yu
Objective: The aim of this study is to detect the expression of EGFRvⅢ and CXCR4 in HNSCC and to explore its possible mechanism. Method: We selected 60 cases of HNSCC from May 2013 to November 2016 in our hospital for surgical treatment, including 44 cases of laryngeal squamous cell carcinoma, 14 cases of hypopharyngeal squamous cell carcinoma, and 2 cases of nasal squamous cell carcinoma. pTNM staging according to AJCC 2010, Ⅲ stage 17 cases, Ⅳa stage 40 cases, and Ⅳb stage 3 cases; according to tumor differentiation degree: 13 cases of high differentiation, moderately differentiation in 31 cases, and 16 cases of low differentiated; primary tumor, positive lymph node metastasis as the experimental group, and 10 cases of adjacent tissues are taken as control (control group)...
June 5, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29774941/-meta-analysis-of-gastric-stump-cancer-after-gastrectomy-for-gastric-cancer
#13
Yongbai Li, Zhidong Gao, Xuesong Zhao, Bo Wang, Yingjiang Ye, Shan Wang, Kewei Jiang
OBJECTIVE: To study the clinicopathological features and prognosis of gastric stump cancer (GSC) following subtotal gastrectomy for gastric cancer, to compare the clinicopathologic differences between narrow GSC and generalized GSC, and to compare the prognosis between GSC and primary proximal gastric cancer (PPGC) after radical resection. METHODS: Literatures of GSC-associated clinical study were searched by computer from the Cochrane Library, Medline, PubMed, CNKI, Wanfang and VIP databases, and the retrieval period was from the establishment of database to December 31, 2017...
May 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29774935/-clinicopathological-characteristics-and-prognosis-analysis-of-217-patients-with-carcinoma-in-the-remnant-stomach
#14
Xiaodong Liu, Zhaojian Niu, Dong Chen, Dongsheng Wang, Liang Lyu, Haitao Jiang, Jian Zhang, Yu Li, Shougen Cao, Yanbing Zhou
OBJECTIVE: To evaluate the clinicopathological features and prognostic factors of carcinoma in the remnant stomach (CRS). METHODS: Clinicopathological data of 217 consecutive CRS patients from January 2000 to March 2017 at Department of Gastrointestinal Surgery, The Affiliated Hospital of Qingdao University were retrospectively analyzed. CRS was defined as the primary cancer arising from the remnant stomach following gastrectomy, regardless of the initial disease or operation, and at no special time interval...
May 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29774934/-comparison-of-clinicopathological-features-and-prognosis-analysis-between-carcinoma-in-the-remnant-stomach-and-gastric-cancer
#15
Fengke Li, Yimin Wang, Chunfeng Li, Yan Ma, Yongle Zhang, Zhiguo Li, Yingwei Xue
OBJECTIVE: To compare clinicopathological features and prognosis between patients with carcinoma in the remnant stomach (CRS) and with gastric cancer, and to investigate the prognostic factors in CRS patients. METHODS: A retrospective cohort study was performed on clinicopathological data of 96 CRS patients (CRS group) and selected 440 patients with gastric cancer (GC group) treated at Harbin Medical University Cancer Hospital from January 1977 to December 2017...
May 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29774932/-pathological-staging-criteria-for-carcinoma-in-the-remnant-stomach-an-exploratory-study
#16
Zhidong Gao, Xuesong Zhao, Kewei Jiang, Bo Wang, Yongbai Li, Yingjiang Ye, Shan Wang
OBJECTIVE: To explore the prognostic value of the tumor-ratio-metastasis (TRM) staging system for carcinoma in the remnant stomach(CRS). METHODS: Clinicopathological data of 91 CRS patients who underwent surgery at Peking University People's Hospital between March 1992 and December 2017 were retrospectively analyzed. According to the ratio of metastatic lymph node to dissected lymph node, the R staging was obtained, and the pN staging was replaced by the R staging to create the TRM staging...
May 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29771411/long-non-coding-rna-zeb1-as1-is-associated-with-poor-prognosis-in-gastric-cancer-and-promotes-cancer-cell-metastasis
#17
X-J Liu, S-L Li, J-S Li, H Lu, L-L Yin, W-F Zheng, W-C Wang
OBJECTIVE: To investigate the expression of long non-coding RNA zinc-finger E-box binding homeobox 1-AS1 (lncRNA ZEB1-AS1) in gastric cancer cells and tissues, to study its effect on the gastric cancer cell metastasis capacity, and analyze its clinical significance. PATIENTS AND METHODS: The relative expression level of lncRNA ZEB1-AS1 in gastric cancer cells was detected via quantitative reverse transcription polymerase chain reaction (qRT-PCR). Transwell assay was used to detect the effects of lncRNA ZEB1-AS1 on the invasion and metastasis capacities of gastric cancer cells...
May 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29771033/-the-effects-and-expression-of-survivin-and-aurora-b-in-laryngeal-carcinoma
#18
C H Hu, W H Wang, Q Wang, X S He
Objective: The aim of this study is to investigate the relationship between the expression of Survivin and Aurora-b in laryngeal carcinoma and its clinical and pathological features, and to determine the possibility of Survivin and Aurora-b being a biomarker in laryngeal carcinoma diagnosis or being an predictor of overall survival (OS) in laryngeal carcinoma patients underwent surgical resection. Method: Eighty-six cases of laryngeal carcinoma tissues diagnosed by pathology were collected, and 86 cases of adjacent tissues and 22 cases of normal tissues were selected as control...
May 20, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29770845/real-world-study-of-a-novel-prognostic-scoring-system-for-a-more-precise-prognostication-and-better-clinical-treatment-guidance-in-stages-ii-and-iii-colon-cancer
#19
Qi Liu, Yanlei Ma, Dakui Luo, Sanjun Cai, Qingguo Li, Xinxiang Li
PURPOSE: This study aimed to improve the American Joint Committee on Cancer (AJCC) Tumor Node Metastases (TNM) staging system and demonstrate the improvement in prognostic accuracy and clinical management guidance in colon cancer using the novel prognostic score (P score). METHODS: Eligible patients were identified using the Surveillance, Epidemiology, and End Results database. A P score (based on age, tumor size, and tumor grade) was assigned to each patient. The Cox proportional hazards regression analyses were performed to identify independent factors associated with prognosis...
May 16, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29770566/refining-definitions-within-low-risk-differentiated-thyroid-cancers
#20
Iain J Nixon, Ricard S Simo, Dae Kim
Improvements in risk stratification have identified three distinct groups of patients with differentiated thyroid cancer. Those at highest risk who require intensive treatment, those at almost no risk who can safely be managed with a conservative approach and a remaining low risk group. This low risk group are at very low risk of death but are at risk of recurrence. Changes in international guidelines now consider such patients as potential candidates for management with thyroid lobectomy rather than total thyroidectomy and radioactive iodine...
May 16, 2018: Clinical Otolaryngology
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