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https://www.readbyqxmd.com/read/28544802/prognostic-models-and-nomograms-for-predicting-survival-of-patients-with-maxillary-sinus-carcinomas
#1
Weidong Shen, Naoko Sakamoto, Limin Yang
BACKGROUND: Maxillary sinus carcinoma is an uncommon malignancy. Most reports on prognosis of this disease are from single institutions and include few patients. We used data from the United States National Cancer Institute's Surveillance Epidemiology and End Results (SEER) program to construct models and nomograms for predicting outcomes of patients with maxillary sinus carcinomas. METHODS: We used records from 668 patients with primary maxillary sinus carcinomas reported to the SEER program from 2004 to 2013 to build nomograms based on stratified multivariable Cox proportional hazard models for predicting 5-year overall survival (OS) and cause-specific survival (CSS)...
May 23, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28543074/wwc3-regulates-the-wnt-and-hippo-pathways-via-dvls-and-lats1-to-suppress-lung-cancer-invasion-and-metastasis
#2
Qiang Han, Xuyong Lin, Xiupeng Zhang, Guiyang Jiang, Yong Zhang, Yuan Miao, Xuezhu Rong, Xiaoying Zheng, Yong Han, Xu Han, Jingjing Wu, Joachim Kremerskothen, Enhua Wang
The scaffolding protein WWC (WW and C2-domain containing) family is known to regulate cell proliferation and organ size via the Hippo signalling pathway. However, the expression level of WWC3 in human tumours and the mechanisms underlying its role in cellular signal transduction have not yet been reported. Herein, we explored the potential roles of WWC3 in lung cancer cells and the corresponding molecular mechanisms. We found low WWC3 expression in both lung cancer cell lines and lung cancer specimens, which was associated with low differentiation, advanced p-TNM stage, positive lymph node metastasis, and poor prognosis in patients with lung cancer...
May 25, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28542982/cancer-associated-fibroblast-derived-lumican-promotes-gastric-cancer-progression-via-the-integrin-%C3%AE-1-fak-signaling-pathway
#3
Xiaofeng Wang, Quan Zhou, Zhenjia Yu, Xiongyan Wu, Xuehua Chen, Jianfang Li, Chen Li, Min Yan, Zhenggang Zhu, Bingya Liu, Liping Su
Gastric cancer (GC) is one of the most frequent malignant tumors worldwide and is associated with high invasiveness, high metastasis, and poor prognosis. Cancer-associated fibroblasts (CAFs), residing around tumor cells in tumor stroma, are important modifiers of tumor initiation and progression. However, the molecular mechanisms by which CAF's modulate tumor development have yet not to be characterized in GC. Here we performed tissue assay analyses identifying that Lumican, an extracellular matrix protein, is highly expressed in human gastric CAFs and its expression is positively associated with depth of invasion, lymph node metastasis, TNM stage, and poor survival rate of GC...
May 23, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28542283/shared-susceptibility-loci-at-2q33-region-for-lung-and-esophageal-cancers-in-high-incidence-areas-of-esophageal-cancer-in-northern-china
#4
Xue Ke Zhao, Yi Min Mao, Hui Meng, Xin Song, Shou Jia Hu, Shuang Lv, Rang Cheng, Tang Juan Zhang, Xue Na Han, Jing Li Ren, Yi Jun Qi, Li Dong Wang
BACKGROUND: Cancers from lung and esophagus are the leading causes of cancer-related deaths in China and share many similarities in terms of histological type, risk factors and genetic variants. Recent genome-wide association studies (GWAS) in Chinese esophageal cancer patients have demonstrated six high-risk candidate single nucleotide polymorphisms (SNPs). Thus, the present study aimed to determine the risk of these SNPs predisposing to lung cancer in Chinese population. METHODS: A total of 1170 lung cancer patients and 1530 normal subjects were enrolled in this study from high-incidence areas for esophageal cancer in Henan, northern China...
2017: PloS One
https://www.readbyqxmd.com/read/28540633/olfactory-neuroblastoma-a-single-center-experience
#5
Marton König, Terje Osnes, Peter Jebsen, Jan Folkvard Evensen, Torstein R Meling
Olfactory neuroblastoma (ONB) is a potentially curable disease, despite being an aggressive malignancy with a poor natural history. Our goal was to evaluate management outcomes for patients with ONB treated at our institution. Our prospective database for brain tumors and the pathology registry of head and neck cancers at Oslo University Hospital were searched to identify all patients treated for ONB between 1998 and 2016. Variables extracted from these databases, supplemented by retrospective chart reviews, underwent thorough analysis...
May 25, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/28539817/high-level-of-plasma-egfl6-is-associated-with-clinicopathological-characteristics-in-patients-with-oral-squamous-cell-carcinoma
#6
Chun-Yi Chuang, Mu-Kuan Chen, Ming-Ju Hsieh, Chia-Ming Yeh, Chiao-Wen Lin, Wei-En Yang, Shun-Fa Yang, Ying-Erh Chou
EGF-like domain 6 (EGFL6), a member of the epidermal growth factor (EGF) repeat protein superfamily, is a secreted protein that promotes endothelial cell migration and angiogenesis. The current study investigated the association between the clinicopathological characteristics and plasma level of EGFL6 in patients with oral squamous cell carcinoma (OSCC). We measured the plasma EGFL6 levels of 392 OSCC patients by using a commercial enzyme-linked immunosorbent assay. We also analyzed EGFL6 mRNA levels of 328 OSCC patients from The Cancer Genome Atlas (TCGA) dataset...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/28539214/validation-of-the-eighth-edition-of-the-tnm-staging-system-for-lung-cancer-in-2043-surgically-treated-patients-with-non-small-cell-lung-cancer
#7
Kezhong Chen, Haiqing Chen, Fan Yang, Xizhao Sui, Xiao Li, Jun Wang
PURPOSE: The International Association for the Study of Lung Cancer has proposed a revision of the Tumor, Node, Metastasis (TNM) classification for lung cancer. The purpose of this study is to evaluate the prognostic value of the eighth edition of the TNM staging system in surgically treated patients with non-small-cell lung cancer. METHODS: Data from 2043 consecutive patients with non-small-cell lung cancer who underwent surgical treatment in our single center between January 2006 and September 2015 were collected and analyzed retrospectively...
April 12, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/28537682/elevated-ndc80-expression-is-associated-with-poor-prognosis-in-osteosarcoma-patients
#8
B Xu, D-P Wu, R-T Xie, L-G Liu, X-B Yan
OBJECTIVE: Osteosarcoma (OS) is a commonly diagnosed bone malignancy in children and adolescents. Nuclear division cycle 80 (NDC80) is a crucial regulator of the cell division cycle that has recently been identified as a novel oncoprotein in various solid tumors; however, its role in OS remains poorly understood. The aim of this study was to investigate correlations between NDC80 expression in OS patients and clinicopathological features and prognosis. PATIENTS AND METHODS: We began this study by determining NDC80 expression in sarcoma patients using the Oncomine Platform...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28537676/down-regulation-of-mir-342-3p-in-hepatocellular-carcinoma-tissues-and-its-prognostic-significance
#9
Y Gao, S-G Zhang, Z-H Wang, J-C Liao
OBJECTIVE: The involvement of microRNAs in cancer and their potential as biomarkers of prognosis are becoming increasingly appreciated. The aim of this study was to evaluate the clinical importance and prognostic value of miR-342-3p in hepatocellular carcinoma (HCC). PATIENTS AND METHODS: RT-PCR was used to detect the expression of miR-342-3p. The association with clinicopathologic features was analyzed. Kaplan-Meier survival analysis and Cox proportional hazards analysis were used to compare the overall survival between HCC patients with high miR-342-3p expression and those with low miR-342-3p expression...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28537675/downregulation-of-long-non-coding-rna-linc01133-is-predictive-of-poor-prognosis-in-colorectal-cancer-patients
#10
J-H Zhang, A-Y Li, N Wei
OBJECTIVE: This study aims to investigate long non-coding RNA LINC01133 (LINC01133) expressions in colorectal cancer (CRC) patients, and discuss its correlation with CRC clinicopathological features and prognosis. PATIENTS AND METHODS: qRT-PCR was performed to measure expression levels of LINC01133 in CRC tissues. The chi-square test was used to assess LINC01133 expression with respect to clinicopathological parameters. Kaplan-Meier analysis and the log-rank test were performed to identify survival differences in CRC patients...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28537667/mechanism-of-the-high-coagulation-state-of-breast-cancer-tissue-factor
#11
X-K Mi, Q-R Liu, L Zhu, M-X Sang, L-R Guo, B-E Shan
OBJECTIVE: We conducted this study to analyze the mechanism behind the high coagulation state induced by circulating plasma microparticle tissue factor (MP-TF) in patients with breast cancer. PATIENTS AND METHODS: 87 cases of breast cancer patients (10 cases of TNM stage I, 16 cases of II, 32 cases of III, 29 cases of IV; 8 cases of pathological type in situ carcinoma, 15 cases of ductal carcinoma, 64 cases of invasive cancer) were used as the observation group and 20 cases of benign breast lesions were used as the control group to compare MP-TF levels of plasma and coagulation parameters including prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB) and D-dimer body (D-D) level and NF-κB signaling pathway index including P50, p65, TAK1 and IκBα levels...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28536490/apparent-diffusion-coefficient-by-diffusion-weighted-magnetic-resonance-imaging-as-a-sole-biomarker-for-staging-and-prognosis-of-gastric-cancer
#12
Francesco Giganti, Alessandro Ambrosi, Damiano Chiari, Elena Orsenigo, Antonio Esposito, Elena Mazza, Luca Albarello, Carlo Staudacher, Alessandro Del Maschio, Francesco De Cobelli
OBJECTIVE: To investigate the role of apparent diffusion coefficient (ADC) from diffusion-weighted magnetic resonance imaging (DW-MRI) when applied to the 7th TNM classification in the staging and prognosis of gastric cancer (GC). METHODS: Between October 2009 and May 2014, a total of 89 patients with non-metastatic, biopsy proven GC underwent 1.5T DW-MRI, and then treated with radical surgery. Tumor ADC was measured retrospectively and compared with final histology following the 7th TNM staging (local invasion, nodal involvement and according to the different groups - stage I, II and III)...
April 2017: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/28536488/satisfactory-surgical-outcome-of-t2-gastric-cancer-after-modified-d2-lymphadenectomy
#13
Shupeng Zhang, Liangliang Wu, Xiaona Wang, Xuewei Ding, Han Liang
OBJECTIVE: Though D2 lymphadenectomy has been increasingly regarded as standard surgical procedure for advanced gastric cancer (GC), the modified D2 (D1 + 7, 8a and 9) lymphadenectomy may be more suitable than D2 dissection for T2 stage GC. The purpose of this study is to elucidate whether the surgical outcome of modified D2 lymphadenectomy was comparable to that of standard D2 dissection in T2 stage GC patients. METHODS: A retrospective cohort study with 77 cases and 77 controls matched for baseline characteristics was conducted...
April 2017: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/28536340/-a-case-of-advanced-transverse-colon-cancer-with-nephrotic-syndrome-treated-with-curative-resection-and-complete-adjuvant-chemotherapy
#14
Nobutaka Sato, Seiya Fuyuno, Teppei Hatada, Takashi Furuhashi, Toshihiko Abe
A 74-year-old woman was diagnosed as having transverse colon cancer after diagnosis of nephrotic syndrome caused by membranous nephropathy. Although she had hypoproteinemia and hypoalbuminemia, we judged that she had no major nutritional problem. In previous, similar case reports, the use of human serum albumin and fresh-frozen plasma was suggested to be important to avoid complications in the perioperative period. Thus, we used the same in our patient in the perioperative period. In addition, we paid special attention to perioperative nutrition management and used total parenteral nutrition in perioperative period...
May 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28535628/-expression-and-clinical-significance-of-long-non-coding-rna-ccat1-in-gastric-cancer
#15
T Shan, Y G Chen, B Hong, H Zhou, J Z Xia
Objective: To investigate the expression and clinical significance of long non-coding RNA colon cancer associated transcript-1 (CCAT1) in gastric cancer (GC), and to further explore the effect of CCAT1 on cell proliferation of GC. Methods: The mRNA expressions of CCAT1 in GC tissues and matched adjacent normal tissues from 62 patients who received resection for gastric carcinoma between January 2013 and May 2015 in Nanjing Medical University Affiliated Wuxi Second Hospital and expressions in GC cell lines were assessed by quantitative real-time PCR (qRT-PCR)...
May 16, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28535625/-expression-and-clinical-significance-of-ser10-phosphorylated-p27-kip1-protein-in-human-breast-carcinoma
#16
Z Q Guo, Q S Lü, Z Wang, L H Lu, N Lu, X W Wen, W X Wu, M Yao
Objective: To explore the expression and clinicopathological significance of Ser10 phosphorylated p27(kip1)(P-p27Ser10) protein in human breast carcinoma tissue. Methods: Tissue specimens were obtained from 111 cases with breast carcinoma from January 2004 to December 2005. And the expression of P-p27Ser10 protein for each specimen was detected by immunohistochemical (EnVision) analysis. Six representative paired samples of cancerous and paired adjacent normal tissues were collected and detected by Western blot...
May 16, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28535151/correlations-of-hemoglobin-level-and-perioperative-blood-transfusion-with-the-prognosis-of-gastric-cancer-a-retrospective-study
#17
Gang Wu, Dai-Yang Zhang, Yu-Han Duan, Ying-Qiong Zhang, Xian-Nian Cui, Zheng Luo
BACKGROUND This study was designed to explore the correlations of hemoglobin level (Hb) and perioperative blood transfusion with the prognosis of gastric cancer (GC). MATERIAL AND METHODS Our study consisted of 210 patients with GC who all received a D2 radical operation. These patients were assigned into three groups: 68 cases in group A (blood transfusion >5 U); 59 cases in group B (blood transfusion <5 U); 83 cases in group C (without blood transfusion). A 5-year follow-up was conducted to evaluate the disease-free survival of the patients...
May 23, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28534972/identification-of-mir%C3%A2-124a-as-a-novel-diagnostic-and-prognostic-biomarker-in-non%C3%A2-small-cell-lung-cancer-for-chemotherapy
#18
Pei Luo, Qing Yang, Le-Le Cong, Xiao-Feng Wang, Yu-Sheng Li, Xiao-Ming Zhong, Ru-Ting Xie, Cheng-You Jia, Hui-Qiong Yang, Wen-Ping Li, Xian-Ling Cong, Qing Xia, Da Fu, Qing-Hua Zeng, Yu-Shui Ma
Previous studies have suggested that dysregulation of microRNA (miR) -124a is associated with various types of human cancer. However, there are few studies reporting the level of miR‑124a expression in non‑small cell lung cancer (NSCLC). The present study investigated the association between miR‑124a and NSCLC by analyzing the differential expression of miR‑124a in NSCLC using the GEO database, as well as subsequently performing reverse transcription‑quantitative polymerase chain reaction analysis on 160 NSCLC biopsies, 32 of which were paired with adjacent normal tissues...
May 17, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28534938/metadherin-regulates-actin-cytoskeletal-remodeling-and-enhances-human-gastric-cancer-metastasis-via-epithelial-mesenchymal-transition
#19
Yaqiong Du, Bojian Jiang, Shuzheng Song, Guoqing Pei, Xiaochun Ni, Jugang Wu, Shoulian Wang, Zhengyuan Wang, Jiwei Yu
Metadherin (MTDH) can be recruited to mature tight junction complexes, and it regulates mesenchymal marker protein expression in many tumors and promote cancer metastasis. This study investigated the influence of MTDH expression on gastric cancer and to elucidate the potential mechanisms by which MTDH regulates actin cytoskeletal remodeling and enhances human gastric cancer metastasis via epithelial-mesenchymal transition (EMT). Relative MTDH mRNA expression levels were assessed by quantitative real-time PCR (Q-PCR), and MTDH protein expression levels and localization were evaluated via immunohistochemical (ICH) staining...
May 17, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28534365/laparoscopic-surgery-as-a-treatment-option-for-elderly-patients-with-colon-cancer
#20
Xiaogang Zhou, Ling Wang, Wang Shen
PURPOSE: With the increase in life expectancy, the use of laparoscopic surgery in elderly patients with colon cancer is gaining interest. The aim of this study was to identify the impact of laparoscopic surgery on elderly patients with colon cancer in comparison with open surgery. In addition, we evaluated the role of surgery in elderly patients with colon cancer by assessing long-term outcomes. METHODS: We retrospectively reviewed clinical data of 203 colon cancer patients aged ≥75 years who underwent radical surgery by either laparoscopy or open surgery from January 2009 to January 2015...
March 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
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