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https://www.readbyqxmd.com/read/27901388/systemic-and-ocular-immune-responses-in-cattle-following-intranasal-vaccination-with-precipitated-or-partially-solubilized-recombinant-moraxella-bovis-cytotoxin-adjuvanted-with-polyacrylic-acid
#1
John A Angelos, Munashe Chigerwe, Judy M Edman, John F Hess
OBJECTIVE To evaluate changes in systemic and ocular antibody responses of steers following intranasal vaccination with precipitated or partially solubilized recombinant Moraxella bovis cytotoxin (MbxA). ANIMALS 13 Angus steers with ages ranging from 318 to 389 days and weights ranging from 352 to 437 kg. PROCEDURES Steers were assigned to receive 500 μg of a precipitated (MbxA-P; n = 5) or partially solubilized (MbxA-S; 5) recombinant MbxA subunit adjuvanted with polyacrylic acid. A control group (n = 3) received the adjuvant alone...
December 2016: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/27889980/-the-importance-of-free-nucleic-acids-in-the-non-invasive-diagnostics
#2
Bálint Nagy, Zoltán Csanádi, Róbert Póka
There is a great interest to determine the physiological role of "free" nucleic acids, and to use them in the clinical diagnostics. These could be DNA, mRNA, microRNA and long non-coding RNA molecules, they are in the body fluids, like serum, tear, saliva, etc. Their exact role in the normal and pathological physiological processes is still in the focus of the research, while their use in the diagnostics is becoming more and more important. The use of "free" DNA in the non-invasive prenatal diagnosis is the first clinical application of the new generation sequencers, these methods are able to reach 99...
November 2016: Orvosi Hetilap
https://www.readbyqxmd.com/read/27874256/correlation-of-vitamin-d-levels-with-tear-film-stability-and-secretion-in-patients-with-dry-eye-syndrome
#3
Ki Won Jin, Jin Woo Ro, Young Joo Shin, Joon Young Hyon, Won Ryang Wee, Shin Goo Park
PURPOSE: To investigate tear film stability and secretion according to serum 25-hydroxyvitamin D3 [25(OH)D] levels in dry eye patients. METHODS: In this retrospective observational study, the medical charts of 92 patients who visited the Department of Ophthalmology at Hallym University Kangnam Sacred Heart Hospital from April to August 2015 were reviewed. Serum 25(OH)D levels were measured. Subjects were divided into three groups according to serum 25(OH)D levels: sufficient, inadequate or deficient group...
November 22, 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27835065/sustained-delivery-of-timolol-maleate-for-over-90-days-by-subconjunctival-injection
#4
Erin Lavik, Markus H Kuehn, Andrew J Shoffstall, Kristyn Atkins, Alina V Dumitrescu, Young H Kwon
PURPOSE: Medical treatment of glaucoma relies on intraocular pressure (IOP)-lowering medications, typically administered daily by the patient. While these medications are effective when applied correctly, patient adherence is a major obstacle in glaucoma treatment. We have developed a sustained-release formulation of timolol maleate that can be injected subconjunctivally to avoid patient noncompliance. METHODS: A biodegradable microsphere formulation for timolol maleate was injected subconjunctivally in normal rabbits...
November 11, 2016: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27815483/effect-of-autologous-serum-eye-drops-in-patients-with-sj%C3%A3-gren-syndrome-related-dry-eye-clinical-and-in-vivo-confocal-microscopy-evaluation-of-the-ocular-surface
#5
Francesco Semeraro, Eliana Forbice, Giuseppe Nascimbeni, Marco Taglietti, Vito Romano, Germano Guerra, Ciro Costagliola
AIM: To evaluate in vivo changes after therapy using autologous serum (AS) eye drops in Sjögren's syndrome (SS)-related dry eyes by confocal microscopy. PATIENTS AND METHODS: In this study, 24 patients with SS-related dry eyes [12 in AS eye drop therapy and 12 in artificial tear (AT) therapy] and 24 healthy volunteers were recruited. Ocular Surface Disease Index (OSDI), central corneal thickness, tear film, break-up time, corneal and conjunctival staining, Schirmer's test and corneal confocal microscopy were investigated...
November 2016: In Vivo
https://www.readbyqxmd.com/read/27813662/matrix-metalloproteinase-activity-and-prostaglandin-e2-are-elevated-in-the-synovial-fluid-of-meniscus-tear-patients
#6
Betty Liu, Adam P Goode, Teralyn E Carter, Gangadhar M Utturkar, Janet L Huebner, Dean C Taylor, Claude T Moorman Iii, William E Garrett, Virginia B Kraus, Farshid Guilak, Louis E DeFrate, Amy L McNulty
PURPOSE: Meniscus tears are a common knee injury and are associated with the development of post-traumatic osteoarthritis (OA). The purpose of this study was to evaluate potential OA mediators in the synovial fluid and serum of meniscus tear subjects compared to those in the synovial fluid of radiographic non-OA control knees. MATERIALS AND METHODS: Sixteen subjects with an isolated unilateral meniscus injury and six subjects who served as reference controls (knee Kellgren-Lawrence grade 0-1) were recruited...
November 4, 2016: Connective Tissue Research
https://www.readbyqxmd.com/read/27811278/the-effects-of-transdermal-testosterone-and-oestrogen-therapy-on-dry-eye-in-postmenopausal-women-a-randomised-placebo-controlled-pilot-study
#7
Blanka Golebiowski, Noor Badarudin, John Eden, Leanne Gerrand, Jennifer Robinson, Jinzhu Liu, Ulrike Hampel, Jingjing You, Fiona Stapleton
AIMS: Sex hormones could provide a future treatment avenue for dry eye post menopause. However, there are few well-controlled studies. This study investigates the impact of testosterone and oestrogen on dry eye symptoms and signs in postmenopausal women. METHODS: A randomised double-blind placebo-controlled pilot study was conducted involving 40 women with dry eye (age 63.9±5.1 years, 13.2±6.3 years post menopause). Ten women were assigned to each of four treatment groups: transdermal testosterone, oestradiol, testosterone/oestradiol combination and placebo...
November 3, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27805438/measurement-of-cortisol-concentration-in-the-tears-of-horses-and-ponies-with-pituitary-pars-intermedia-dysfunction
#8
Kelsey A Hart, Kalyn M Kitchings, Shune Kimura, Natalie A Norton, Kathern E Myrna
OBJECTIVE To compare tear cortisol concentrations between horses and ponies with pituitary pars intermedia dysfunction (PPID) and healthy nonaged (≤ 15 years old) and aged (≥ 20 years old) horses and to determine whether serum and tear cortisol concentrations were correlated. ANIMALS 11 horses and ponies with PPID and 20 healthy control horses and ponies (11 nonaged and 9 aged). PROCEDURES Paired tear and serum samples were obtained from PPID and control animals. All animals were free of active ocular disease...
November 2016: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/27792147/icariin-promotes-tendon-bone-healing-during-repair-of-rotator-cuff-tears-a-biomechanical-and-histological-study
#9
Chenyi Ye, Wei Zhang, Shengdong Wang, Shuai Jiang, Yuanbin Yu, Erman Chen, Deting Xue, Jianzhong Chen, Rongxin He
To investigate whether the systematic administration of icariin (ICA) promotes tendon-bone healing after rotator cuff reconstruction in vivo, a total of 64 male Sprague Dawley rats were used in a rotator cuff injury model and underwent rotator cuff reconstruction (bone tunnel suture fixation). Rats from the ICA group (n = 32) were gavage-fed daily with ICA at 0.125 mg/g, while rats in the control group (n = 32) received saline only. Micro-computed tomography, biomechanical tests, serum ELISA (calcium; Ca, alkaline phosphatase; AP, osteocalcin; OCN) and histological examinations (Safranin O and Fast Green staining, type I, II and III collagen (Col1, Col2, and Col3), CD31, and vascular endothelial growth factor (VEGF)) were analyzed two and four weeks after surgery...
October 25, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27778251/biomarkers-of-diabetic-retinopathy
#10
Daniel Shu Wei Ting, Kara-Anne Tan, Val Phua, Gavin Siew Wei Tan, Chee Wai Wong, Tien Yin Wong
Diabetic retinopathy (DR), a leading cause of acquired vision loss, is a microvascular complication of diabetes. While traditional risk factors for diabetic retinopathy including longer duration of diabetes, poor blood glucose control, and dyslipidemia are helpful in stratifying patient's risk for developing retinopathy, many patients without these traditional risk factors develop DR; furthermore, there are persons with long diabetes duration who do not develop DR. Thus, identifying biomarkers to predict DR or to determine therapeutic response is important...
December 2016: Current Diabetes Reports
https://www.readbyqxmd.com/read/27759431/human-breast-milk-drops-promote-corneal-epithelial-wound-healing
#11
Leyla Asena, Esra Hülya Suveren, Gülten Karabay, Dilek Dursun Altinors
PURPOSE: To investigate the effects of human breast milk on corneal epithelial wound healing. METHODS: The effects of human breast milk on epithelial healing is compared with autologous serum and artificial tears on 24 female Bal-b/C mice. A central corneal epithelial defect was created using a 2 mm trephine. Four groups were formed. By a random pick-up, topical human breast milk 4 × 1 was given to Group 1, topical mouse autologous serum 4 × 1 was applied to Group 2, and preservative-free artificial tears 4 × 1 was applied to Group 3...
October 19, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27747924/results-of-screening-of-apparently-healthy-senior-and-geriatric-dogs
#12
A Willems, D Paepe, S Marynissen, P Smets, I Van de Maele, P Picavet, L Duchateau, S Daminet
BACKGROUND: There is a growing interest in health care of elderly dogs; however, scientific information about physical and laboratory examination findings in this age group is limited. OBJECTIVES: To describe systolic blood pressure (SBP), and results of physical examination and laboratory tests in senior and geriatric dogs that were judged by the owner to be healthy. ANIMALS: Hundred client-owned dogs. METHODS: Dogs were prospectively recruited...
October 17, 2016: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/27698364/vitamin-d-supplementation-for-patients-with-dry-eye-syndrome-refractory-to-conventional-treatment
#13
Seok Hyun Bae, Young Joo Shin, Ha Kyoung Kim, Joon Young Hyon, Won Ryang Wee, Shin Goo Park
This study investigated the effect of vitamin D supplementation in patients with dry eye syndrome (DES) refractory to conventional treatment with vitamin D deficiency. A total of 105 patients with DES refractory to conventional treatment and vitamin D deficiency that was treated with an intramuscular injection of cholecalciferol (200,000 IU). Serum 25-hydroxyvitamin D (25(OH)D) levels were measured. Eye discomfort was assessed using ocular surface disease index (OSDI) and visual analogue pain score (VAS). Tear break-up time (TBUT), fluorescein staining score (FSS), eyelid margin hyperemia, and tear secretion test were measured before treatment, and 2, 6, and 10 weeks after vitamin D supplementation...
October 4, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27684086/serum-cartilage-biomarkers-and-shoulder-instability
#14
Brett D Owens, Kenneth L Cameron, Steven L Bokshan, Kari B Clifton, Steven J Svoboda, Jennifer Moriatis Wolf
Differences in cartilage biomarkers have been noted in patients with anterior cruciate ligament tears, but little is known about any similar relationship with shoulder instability. This study evaluated the relationship between serum cartilage biomarkers and shoulder instability. The authors present a prospective cohort study of young athletes followed from 2006 to 2010. A nested case-control analysis was conducted within this cohort to evaluate the association between preinjury collagen type II cleavage (a marker for type II collagen cleavage) and procollagen II carboxy propeptide (a marker of cartilage synthesis) and the subsequent likelihood of shoulder instability during the 4-year follow-up period...
September 29, 2016: Orthopedics
https://www.readbyqxmd.com/read/27668586/effects-of-topical-ocular-application-of-1-trifluridine-ophthalmic-solution-in-dogs-with-experimentally-induced-recurrent-ocular-canine-herpesvirus-1-infection
#15
Chloe B Spertus, Hussni O Mohammed, Eric C Ledbetter
OBJECTIVE To determine the effects of topical ocular application of 1% trifluridine ophthalmic solution in dogs with experimentally induced recurrent ocular canine herpesvirus-1 (CHV-1) infection. ANIMALS 10 specific pathogen-free Beagles. PROCEDURES 12 months prior to the beginning of the randomized, masked, placebo-controlled 30-day trial, latent ocular CHV-1 infection was experimentally induced in each dog by topical ocular inoculation of both eyes with a field strain of CHV-1. Recurrent ocular CHV-1 infection was induced by oral administration of prednisolone for 7 days (starting day 1)...
October 2016: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/27668496/five-year-prose-treatment-for-aniridic-keratopathy
#16
Takashi Kojima, Asato Hasegawa, Tomoaki Nakamura, Naoki Isogai, Takahiro Kataoka, Kazuo Ichikawa
PURPOSE: Aniridic keratopathy is vision-threatening condition in patients with aniridia. The keratopathy occurs due to limbal stem cell deficiency. When conventional treatments fail, surgical treatments such as corneal limbal transplantation or cultivated oral mucosal epithelium transplantation are the alternatives. Here, we report our experience with the management and monitoring of the progress of a case with aniridic keratopathy treated with a scleral lens. CASE REPORT: We describe the case of a 30-year-old woman with aniridic keratopathy in both eyes...
October 2016: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/27636704/a-probiotic-adjuvant-lactobacillus-rhamnosus-enhances-specific-immune-responses-after-ocular-mucosal-immunization-with-chlamydial-polymorphic-membrane-protein-c
#17
Aleksandra Inic-Kanada, Marijana Stojanovic, Emilija Marinkovic, Elisabeth Becker, Elisabeth Stein, Ivana Lukic, Radmila Djokic, Nadine Schuerer, Johannes H Hegemann, Talin Barisani-Asenbauer
Recent advances in the development of chlamydia vaccines, using live-attenuated or ultraviolet light-inactivated chlamydia, are paving the way for new possibilities to oppose the societal challenges posed by chlamydia-related diseases, such as blinding trachoma. An effective subunit vaccine would mitigate the risks associated with the use of a whole-cell vaccine. Our rationale for the design of an efficient subunit vaccine against Chlamydia trachomatis (Ct) is based on the membrane proteins involved in the initial Ct-host cell contact and on the route of immunization that mimics the natural infection process (i...
2016: PloS One
https://www.readbyqxmd.com/read/27629854/plasmatic-microrna-as-potential-biomarkers-of-multiple-sclerosis-literature-review
#18
REVIEW
Magdalena J Kacperska, Jakub Walenczak, Bartłomiej Tomasik
There is ongoing research with the goal of finding precise and sensitive biomarkers of multiple sclerosis (MS). Recently, researchers have paid particular attention to small, non-encoding, single stranded endogenous microRNA molecules (miR, miRNA). At first these molecules were thought to be found only within the cell. Today it is known, however, that they can also be found in the extracellular spaces (plasma, serum, saliva, urine, tears, sweat, milk, sperm and amniotic fluid, among others). It has been established that extracellular miRNA perform a wide spectrum of functions, such as transmitting signals between cells, modulating processes involved in angiogenesis, neurogenesis, proliferation or apoptosis...
July 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/27595117/correlation-between-tear-fluid-and-serum-vitamin-d-levels
#19
Swaminathan Sethu, Rohit Shetty, Kalyani Deshpande, Natasha Pahuja, Nandini Chinnappaiah, Aarti Agarwal, Anupam Sharma, Arkasubhra Ghosh
BACKGROUND: Vitamin D deficiency is associated with a range of systemic diseases including ocular disorders. The objective of this study is to measure tear vitamin D levels and investigate the correlation between serum and tear vitamin D levels. METHODS: A total of 48 healthy volunteers without any systemic and ocular disease were recruited for this observational cohort study. Serum was collected using clot activator coated Vacutainer® Plus tubes. Tear fluid was collected using Schirmer's strips...
2016: Eye and Vision (London, England)
https://www.readbyqxmd.com/read/27536206/immunomodulation-on-the-ocular-surface-a-review
#20
REVIEW
Anna M Ambroziak, Jerzy Szaflik, Jacek P Szaflik, Maciej Ambroziak, Jan Witkiewicz, Piotr Skopiński
The increasing understanding of immune mechanisms changed our perception of the ocular surface, which is now considered a compartment of the common mucosal immune system. It offered the possibility to alter the physiological immune response on the ocular surface and effectively combat inflammation, which impairs stability of the tear film and causes tear hyperosmolarity, causing symptoms of dry eye disease. The paper provides an overview of ocular surface anatomy and physiology, explains the underlying mechanisms of dry eye disease and discusses novel and promising treatment modalities, such as cyclosporine A, biological therapies using autologous serum and various growth factors as well as experimental treatment methods which are currently being investigated...
2016: Central-European Journal of Immunology
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