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https://www.readbyqxmd.com/read/29318025/feline-dry-eye-syndrome-of-presumed-neurogenic-origin-a-case-report
#1
Lionel Sebbag, Patricia A Pesavento, Sebastian E Carrasco, Christopher M Reilly, David J Maggs
Case summary: A 14-year-old female spayed Abyssinian cat, which about 1 year previously underwent thoracic limb amputation, radiotherapy and chemotherapy for an incompletely excised vaccine-related fibrosarcoma, was presented for evaluation of corneal opacity in the left eye (OS). The ocular surface of both eyes (OU) had a lackluster appearance and there was a stromal corneal ulcer OS. Results of corneal aesthesiometry, Schirmer tear test-1 (STT-1) and tear film breakup time revealed corneal hypoesthesia, and quantitative and qualitative tear film deficiency OU...
January 2018: JFMS Open Reports
https://www.readbyqxmd.com/read/29283120/correlation-of-interleukin-33-with-th-cytokines-and-clinical-severity-of-dry-eye-disease
#2
Guoping Luo, Yan Xin, Dajun Qin, Aihua Yan, Zhiyan Zhou, Zhaoxia Liu
PURPOSE: The purpose of this study is to determine the tear and serum protein levels of interleukin-33 (IL-33) and its correlation with Th cytokines and disease severity in dry eye (DE) syndrome. METHODS: Tear and serum samples were collected from 30 healthy volunteers, 30 DE patients with non-Sjogren's syndrome DE (NSSDE) and 30 DE patients with primary SSDE. The eight most frequent symptoms of DE were scored. All patients underwent corneal and conjunctival staining, tear film breakup time (TBUT), and Schirmer I test...
January 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29279263/tear-osteopontin-level-and-its-relationship-with-local-th1-th2-th17-treg-cytokines-in-children-with-allergic-conjunctivitis
#3
A Yan, G Luo, Z Zhou, W Hang, D Qin
BACKGROUND: Allergic conjunctivitis (AC) is one of the most common allergic ocular diseases worldwide. Osteopontin (OPN), as a recently described Th2 inflammation related protein, may play a role in the pathogenesis of AC. The aim of this study was to identify the expression of OPN in children with AC. METHODS: Eighty AC children (seasonal and perennial AC) and twenty controls were enrolled in this study. Serum and tears of different time points (during and out of the pollen season) were collected and used for enzyme-linked immunosorbent assay (ELISA) of OPN and T-help cell related cytokines, respectively...
December 23, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/29260117/parallel-ocular-and-serologic-course-in-a-patient-with-early-sjogren-s-syndrome-markers
#4
Lam Phung, Ivonne V Lollett, Raquel Goldhardt, Janet L Davis, Larry Young, Dana Ascherman, Anat Galor
Purpose: To report on a case of a young female with progressing dry eye symptoms and evolving autoimmune markers consistent with a presentation of early Sjogren's syndrome (SS). Observations: A 32 year-old female presented with chronic dry eye symptoms refractory to artificial tears. Slit lamp examination revealed punctate epithelial erosions, decreased tear break-up time, and decreased tear lake bilaterally. Initial tests for ocular surface inflammation (InflammaDry, Quidel, San Diego) and systemic autoantibodies (antinuclear antibodies, anti-SSA/Ro and anti-SSB/La) were negative...
December 2017: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29251826/digging-deep-into-peptidomics-applied-to-body-fluids
#5
REVIEW
Rui Vitorino
Peptidomics techniques have allowed the identification of thousands of peptides that are derived from proteins in body fluids, despite the considerable challenges behind sample handling, mass spectrometry-based identification, data analysis and integration with bioinformatics tools. Body fluids' naturally occurring peptides are known to perform a variety of local and systemic functions; however, its knowledge is limited. Even so, the biological meaning that can be retrieved from peptidomics applied to the identification of disease markers and to the development of therapies using peptides has driven the progresses made in this field...
December 18, 2017: Proteomics
https://www.readbyqxmd.com/read/29193311/proteomics-analysis-of-human-breast-milk-to-assess-breast-cancer-risk
#6
Roshanak Aslebagh, Devika Channaveerappa, Kathleen F Arcaro, Costel C Darie
Detection of breast cancer (BC) in young women is challenging because mammography, the most common tool for detecting BC, is not effective on the dense breast tissue characteristic of young women. In addition to the limited means for detecting their BC, young women face a transient increased risk of pregnancy-associated BC. As a consequence, reproductively active women could benefit significantly from a tool that provides them with accurate risk assessment and early detection of BC. One potential method for detection of BC is biochemical monitoring of proteins and other molecules in bodily fluids such as serum, nipple aspirate, ductal lavage, tear, urine, saliva and breast milk...
November 29, 2017: Electrophoresis
https://www.readbyqxmd.com/read/29183042/expression-and-regulation-of-s100-fused-type-protein-hornerin-at-the-ocular-surface-and-lacrimal-apparatus
#7
Fabian Garreis, Janine Jahn, Katharina Wild, Daniel B Abrar, Martin Schicht, Jens-Michael Schröder, Friedrich Paulsen
Purpose: The S100 fused-type proteins hornerin (HRNR) and filaggrin-2 (FLG2) are members of the epidermal differentiation complex, which is involved in terminal differentiation of keratinocytes via cornification as well as maintenance of the epidermal antimicrobial barrier. We investigated the expression and possible regulation of HRNR and FLG2 at the ocular surface and in the lacrimal apparatus. Methods: Tissues of the lacrimal apparatus and ocular surface were analyzed systematically by means of RT-PCR, immunohistochemistry, and immuntransmission electron microscopy (iTEM) for their ability to express and produce HRNR and FLG2...
November 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29154707/objective-evaluation-of-the-systemic-effects-of-topical-application-of-1-atropine-sulfate-ophthalmic-solution-in-healthy-horses
#8
Rita F Wehrman, Anne J Gemensky-Metzler, Ashley E Zibura, Amelia B Nyhart, Heather L Chandler
OBJECTIVE To determine the safety of topical administration of 1% atropine ophthalmic solution in healthy horses by objectively measuring gastrointestinal transit time. DESIGN Randomized, masked, controlled crossover study. ANIMALS 6 adult geldings. PROCEDURES Horses were randomly assigned (3/group) to first receive topical treatment of the left eye with 1% atropine or artificial tears solution; the right eye was left untreated. After 24 hours of treatment every 6 hours, 200 nontoxic beads were administered to each horse via nasogastric intubation and treatment frequency was decreased to every 12 hours for 4 more days...
December 1, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29101724/adjunctive-role-of-self-retained-cryopreserved-amniotic-membrane-in-treating-immune-related-dry-eye-disease
#9
Anny M S Cheng, Sean Tighe, Hosam Sheha, Scheffer C G Tseng
PURPOSE: To present a case of successful treatment of immune-related severe dry eye disease (DED) by self-retained cryopreserved amniotic membrane (CAM) in conjunction with conventional and systemic immunotherapy. OBSERVATIONS: A 48-year-old female with a 10-year history of rheumatoid arthritis under systemic immunomodulation developed non-resolved severe ocular dryness, pain, photophobia and blurred vision due to corneal epithelial keratopathy OD much worse than OS despite topical artificial tears, steroids, cyclosporine, autologous serum drops, punctal plugs and scleral lens for the last 3 years...
November 3, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28967470/involvement-of-synovial-matrix-degradation-and-angiogenesis-in-oxidative-stress-exposed-degenerative-rotator-cuff-tears-with-osteoarthritis
#10
Kyu-Cheol Noh, Sin-Hye Park, Cheol Jung Yang, Geun Woo Lee, Min Ki Kim, Young-Hee Kang
BACKGROUND: Shoulder osteoarthritis is a gradual wearing of the articular cartilage concomitant with degenerative rotator cuff tears (RCTs). This pathologic disorder is related to inflammation, oxidative stress, and angiogenesis. Degenerative alterations may prompt production of cytokines and angiogenesis-related proteins, evoking rotator cuff diseases. This study tested the hypothesis that oxidative stress-responsive mediators can influence joint inflammation of patients with RCT. METHODS: Twelve healthy RCT patients not suffering shoulder osteoarthritis were categorized as the control group, and 24 patients were allocated to 2 RCT groups (RCTP1 and RCTP2), according to severity of RCT and glenohumeral arthritis...
January 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28953600/adhesion-of-stenotrophomonas-maltophilia-delftia-acidovorans-and-achromobacter-xylosoxidans-to-contact-lenses
#11
Ajay Kumar Vijay, Mark D P Willcox
PURPOSE: Contact lens cases become contaminated with microbes during use. We wished to compare the adhesion of uncommon bacterial contaminants isolated from lens cases to contact lenses with and without organic soil. METHODS: Strains of Delftia acidovorans (001), Stenotrophomonas maltophilia (002 and 006), and Achromobacter xylosoxidans (001) isolated from contact lens cases (test strains) and Pseudomonas aeruginosa (Paer1) isolated from eyes at the time of infiltrative response (control strain) were used...
September 26, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28930832/early-central-and-peripheral-corneal-microstructural-changes-in-type-2-diabetes-mellitus-patients-identified-using-in-vivo-confocal-microscopy-a-case-control-study
#12
Jing-Hao Qu, Lei Tian, Xiao-Yu Zhang, Xu-Guang Sun
The aim of this study was to find early central and peripheral corneal microstructural changes in healthy subjects and type 2 diabetes mellitus (T2DM) patients with/without cornea fluorescein dot staining.This is a prospective case-control study of T2DM patients with/without cornea fluorescein dot staining. Age, sex, duration of diabetes, and serum glycosylated hemoglobin A1c (HbA1c) levels were recorded. Keratograph 5 M (K5 M) and in vivo confocal microscopy were performed on all subjects. The cornea was divided into 5 zones: central, superior, temporal, nasal, and inferior...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28919183/impact-of-oral-vitamin-d-supplementation-on-the-ocular-surface-in-people-with-dry-eye-and-or-low-serum-vitamin-d
#13
Chih-Huang Yang, Julie Albietz, Damien G Harkin, Michael G Kimlin, Katrina L Schmid
PURPOSE: To determine the possible association between serum vitamin D levels and dry eye symptoms, and the impact of an oral vitamin D supplement. METHODS: Three linked studies were performed. (i) 29 older adult participants, (ii) 29 dry eyed participants, and (iii) 2-month vitamin D supplementation for 32 dry eyed/low serum vitamin D levelled participants. All participants were assessed by the Ocular Surface Diseases Index (OSDI) to determine dry eye symptoms, and the phenol red thread test (PRT) and/or Schirmer's tear test, tear meniscus height, non-invasive tear break up time, grading ocular surface redness and fluorescein staining of the cornea to detect the tear quality and ocular surface conditions...
September 11, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/28902012/comparison-of-oral-voriconazole-versus-oral-ketoconazole-as-an-adjunct-to-topical-natamycin-in-severe-fungal-keratitis-a-randomized-controlled-trial
#14
Namrata Sharma, Deepali Singhal, Prafulla K Maharana, Rajesh Sinha, Tushar Agarwal, Ashish D Upadhyay, Thirumurthy Velpandian, Gita Satpathy, Jeewan S Titiyal
PURPOSE: To compare the efficacy of oral voriconazole (VCZ) with oral ketoconazole (KCZ) as an adjunct to topical natamycin in severe fungal keratitis. METHODS: Fifty eyes of 50 patients with proven severe fungal keratitis, (>5 mm size, involving >4 mm central cornea and >50% stromal depth), smear, and/or culture positive were randomized to receive either oral VCZ (n = 25) or oral KCZ (n = 25) 200 mg twice a day. Both groups received topical natamycin along with oral medication...
December 2017: Cornea
https://www.readbyqxmd.com/read/28888901/oral-administration-of-undenatured-native-chicken-type-ii-collagen-uc-ii-diminished-deterioration-of-articular-cartilage-in-a-rat-model-of-osteoarthritis-oa
#15
C M Bagi, E R Berryman, S Teo, N E Lane
OBJECTIVE: The aim of this study was to determine the ability of undenatured native chicken type II collagen (UC-II) to prevent excessive articular cartilage deterioration in a rat model of osteoarthritis (OA). METHODS: Twenty male rats were subjected to partial medial meniscectomy tear (PMMT) surgery to induce OA. Immediately after the surgery 10 rats received vehicle and another 10 rats oral daily dose of UC-II at 0.66 mg/kg for a period of 8 weeks. In addition 10 naïve rats were used as an intact control and another 10 rats received sham surgery...
September 6, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28873175/development-of-a-poly-%C3%AE%C2%B5-lysine-contact-lens-as-a-drug-delivery-device-for-the-treatment-of-fungal-keratitis
#16
Andrew G Gallagher, Keri McLean, Rosalind M K Stewart, Don A Wellings, Heather E Allison, Rachel L Williams
Purpose: The purpose of this study was to develop a more efficient drug delivery device to overcome the limitations of current drop therapy for the treatment of fungal keratitis. Methods: Amphotericin B (AmpB), 0 to 30 μg/mL, was associated with a poly-ε-lysine (pεK) hydrogel. Fungicidal effect against Candida albicans was assessed at 18 and 42 hours by optical density (OD600) and growth on agar. Tear film dilution effect was mimicked by storage of AmpB pεK gels in 3...
September 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28853177/recent-advances-in-ce-and-microchip-ce-in-clinical-applications-2014-to-mid-2017
#17
Terry M Phillips
CE and microchip CE (ME)are powerful tools for the analysis of a number of different analytes and have been applied to a variety of clinical fields and human samples. This review will present an overview of the most recent applications of these techniques to different areas of clinical medicine during the period of 2014 to mid-2017. CE and ME have been applied to clinical chemistry, drug detection and monitoring, hematology, infectious diseases, oncology, endocrinology, neonatology, nephrology, and genetic screening...
August 29, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28844373/blood-derived-eye-drops-for-the-treatment-of-cornea-and-ocular-surface-diseases
#18
REVIEW
Giuseppe Giannaccare, Piera Versura, Marina Buzzi, Laura Primavera, Marco Pellegrini, Emilio C Campos
The use of blood derived eye drops for the treatment of ocular surface disorders has become increasingly popular in recent years. The mechanism of action is the stimulation of cellular proliferation and migration by supplying an active mixture of growth factors and cytokines at the ocular surface, thus mimicking the function of the lacking natural tears. Blood derived eye drops have been used in the last decades for the treatment of a variety of ocular surface diseases, including mainly dry eye disease, persistent corneal epithelial defect, corneal ulcer, ocular surface burn, recurrent corneal erosion and limbal stem-cell deficiency...
August 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28808190/cholesterol-crystal-embolization-following-plaque-rupture-a-systemic-disease-with-unusual-features
#19
Firas Ghanem, Deepthi Vodnala, Jagadeesh K Kalavakunta, Sridevi Durga, Noah Thormeier, Prem Subramaniyam, Scott Abela, George S Abela
Cholesterol crystal embolic (CCE) syndrome is often a clinically challenging condition that has a poor prognostic implication. It is a result of plaque rupture with release of cholesterol crystals into the circulation that embolize into various tissue organs. Plaque rupture seems to be triggered by an expanding necrotic core during cholesterol crystallization forming sharp tipped crystals that perforate and tear the fibrous cap. Embolizing cholesterol crystals then initiate both local and systemic inflammation that eventually lead to vascular fibrosis and obstruction causing symptoms that can mimic other vasculitic conditions...
January 19, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/28718904/autologous-serum-eye-drops-and-enhanced-epithelial-healing-time-after-photorefractive-keratectomy
#20
Hanife Tuba Akcam, Metin Unlu, Emine Esra Karaca, Hulya Yazici, Bahri Aydin, Ahmet Murad Hondur
BACKGROUND: The aim of the study is to test whether use of autologous serum eye-drops can provide earlier epithelial healing following the application of photorefractive keratectomy. METHOD: Sixty patients (60 eyes) underwent photorefractive keratectomy for myopia. Thirty eyes received autologous serum drops (Study group) while 30 eyes received conventional artificial tears (Control group) after photorefractive keratectomy. An 8 mm epithelial opening was prepared with the application of 18 per cent alcohol for 20 seconds...
July 18, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
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