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https://www.readbyqxmd.com/read/28523996/micro-rnas-exercise-and-cellular-plasticity-in-humans-the-impact-of-dietary-factors-and-hypoxia
#1
Timothée Watier, Anthony Mj Sanchez
Physical exercise is a stress that modulates a plethora of cellular mechanisms to promote morphological and metabolic adaptations. Substantial efforts have been made to better understand the modulation of pathways involved in cell plasticity during exercise, but human explorations may be limited because invasive procedures are often required. In recent years, minimally invasive methods for the analysis of microRNAs (miRNAs) modulation in response to exercise have been developed. miRNAs are small molecules that belong to a family of non-coding RNAs...
May 19, 2017: MicroRNA
https://www.readbyqxmd.com/read/28515032/bilateral-painless-testicular-mass-acute-uveitis-and-annular-cutaneous-lesions-an-unusual-presentation-of-sarcoidosis-and-literature-review
#2
Enver Şimşek, Tülay Şimşek, Meliha Demiral, Funda Canaz, M Fuat Açıkalın
BACKGROUND: Sarcoidosis is a systemic inflammatory disease characterized by non-caseating epitheloid granulomas; whereas it usually involves the lungs and lymph nodes, genitourinary involvement is extremely rare. For this reason, no consensus regarding the diagnostic and management options for testicular sarcoidosis has been reached. OBJECTIVE: The aim of this case report was to describe an unusual clinical presentation of sarcoidosis. An 8-year-old boy presented with a 6-month history of painless scrotal enlargement and a 2-month history of photophobia, blurred vision, and pain in both eyes...
May 17, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/28487505/lower-serum-vitamin-d-level-was-associated-with-risk-of-dry-eye-syndrome
#3
Yi-Fang Meng, Jiong Lu, Qian Xing, Jian-Jun Tao, Pan Xiao
BACKGROUND To determine the association between serum 25(OH)D and dry eye syndrome (DES) incidence. This study was also designed to determine whether serum 25(OH)D levels were associated with ocular parameter of DES patients. MATERIAL AND METHODS This is a case-control study with 70 DES cases and 70 healthy controls. Clinical data included body mass index (BMI, kg/m²), smoking history, diabetes, and blood pressure. Serum 25(OH)D was chosen as the main parameter and reflected the level of vitamin D. The DES parameters included ocular surface disease index (OSDI) scales, tear film breakup time (TBUT) and Schirmer test I...
May 10, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28460477/inhibition-of-lysophosphatidic-acid-receptor-ameliorates-sj%C3%A3-gren-s-syndrome-in-nod-mice
#4
Eunhye Park, Donghee Kim, Song Mi Lee, Hee-Sook Jun
Lysophosphatidic acid (LPA), a bioactive lysophospholipid, is involved in the pathogenesis of chronic inflammatory and autoimmune diseases. In this study, we investigated the role of LPA/LPA receptor (LPAR) signaling in the pathogenesis of Sjögren's syndrome (SS). We found that autotaxin, an LPA producing enzyme, and LPAR1 and LPAR3 mRNA, and IL-17 mRNA were highly expressed in the exocrine glands of 20-week-old nonobese diabetic (NOD) mice, which show SS symptoms at this age, as compared with non-symptomatic 8-week-old NOD mice...
April 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28451758/the-evaluation-of-diagnostic-efficiency-for-stromal-herpes-simplex-keratitis-by-the-combination-of-tear-hsv-siga-and-hsv-dna
#5
Jini Qiu, Feifei Huang, Zhujian Wang, Jianjiang Xu, Chaoran Zhang
PURPOSE: To assess the differential diagnostic values for stromal herpes simplex keratitis (HSK) by using tear HSV-sIgA, tear HSV-DNA, and the combination. METHODS: Tear samples for both eyes and the paired serum were collected from 187 stromal HSK and 56 controls. Enzyme-linked immune sorbent assay (ELISA) was used to analyze the tear HSV-sIgA and serum IgG/IgM/IgA. The levels of tear HSV-DNA were measured by polymerase chain reaction (PCR). RESULTS: The positive rates for tear HSV-sIgA and HSV-DNA were 36...
April 27, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28438141/prevalence-of-toxocara-antibodies-among-patients-clinically-suspected-to-have-ocular-toxocariasis-a-retrospective-descriptive-study-in-sri-lanka
#6
Devika Iddawela, Kiruthiha Ehambaram, Pemindra Bandara
BACKGROUND: Human toxocariasis, caused by Toxocara canis, T. cati, and T. vitulorum of dogs, cats and ruminants respectively, is recognized as an important zoonotic infection worldwide. The typical clinical syndromes of toxocariasis in humans are ocular larva migrans (OLM) and visceral larva migrans (VLM). The most commonly affected sites of OLM are the peripheral retina and/or vitreous humor. In Sri Lanka, there is a dearth of information on prevalence of ocular infection in our population...
April 24, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28431436/enhanced-tearing-by-electrical-stimulation-of-the-anterior-ethmoid-nerve
#7
Mark Brinton, Andrea L Kossler, Zara M Patel, James Loudin, Manfred Franke, Christopher N Ta, Daniel Palanker
Purpose: Electrical neurostimulation enhances tear secretion, and can be applied to treatment of dry eye disease. Using a chronic implant, we evaluate the effects of stimulating the anterior ethmoid nerve on the aqueous, lipid, and protein content of secreted tears. Methods: Neurostimulators were implanted beneath the nasal mucosa in 13 New Zealand white rabbits. Stimulations (2.3-2.8 mA pulses of 75-875 μs in duration repeated at 30-100 Hz for 3 minutes) were performed daily, for 3 weeks to measure changes in tear volume (Schirmer test), osmolarity (TearLab osmometer), lipid (Oil-Red-O staining), and protein (BCA assay, mass spectrometry)...
April 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28419351/the-effect-of-diatomaceous-earth-in-live-attenuated-infectious-bronchitis-vaccine-immune-responses-and-protection-against-challenge
#8
Ali Nazmi, Rüdiger Hauck, Lynette B Corbeil, Rodrigo A Gallardo
Live virus vaccines are commonly used in poultry production, particularly in broilers. Massive application and generation of a protective local mucosal and humoral immunity with no adverse effects is the main goal for this strategy. Live virus vaccines can be improved by adding adjuvants to boost mucosal innate and adaptive responses. In a previous study we showed that diatomaceous earth (DE) can be used as adjuvant in inactivated vaccines. The aim of this study was to test DE as adjuvant in an Ark-DPI live infectious bronchitis virus (IBV) vaccine after ocular or spray application...
April 17, 2017: Poultry Science
https://www.readbyqxmd.com/read/28411626/quantitative-determination-of-polysulfide-in-albumins-plasma-proteins-and-biological-fluid-samples-using-a-novel-combined-assays-approach
#9
Mayumi Ikeda, Yu Ishima, Akitomo Shibata, Victor T G Chuang, Tomohiro Sawa, Hideshi Ihara, Hiroshi Watanabe, Ming Xian, Yuya Ouchi, Taro Shimizu, Hidenori Ando, Masami Ukawa, Tatsuhiro Ishida, Takaaki Akaike, Masaki Otagiri, Toru Maruyama
Hydrogen sulfide (H2S) signaling involves polysulfide (RSSnSR') formation on various proteins. However, the current lack of sensitive polysulfide detection assays poses methodological challenges for understanding sulfane sulfur homeostasis and signaling. We developed a novel combined assay by modifying Sulfide Antioxidant Buffer (SAOB) to produce an "Elimination Method of Sulfide from Polysulfide" (EMSP) treatment solution that liberates sulfide, followed with methylene blue (MB) sulfide detection assay. The combined EMSP-MB sulfide detection assay performed on low molecular weight sulfur species showed that sulfide was produced from trisulfide compounds such as glutathione trisulfide and diallyl trisulfide, but not from the thiol compounds such as cysteine, cystine and glutathione...
May 29, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28362052/plasmapheresis-intravenous-immunoglobulins-and-autologous-serum-eyedrops-in-the-acute-eye-complications-of-toxic-epidermal-necrolysis
#10
Antonio Pinna, Eleonora Nuvoli, Francesco Blasetti, Maria Alma Posadinu, Francesco Boscia
PURPOSE: Toxic epidermal necrolysis (TEN) is a rare, life-threatening, drug-induced, mucocutaneous disease, which can severely affect the ocular surface. The purpose of this study was to investigate the efficacy of plasmapheresis, human IV immunoglobulins (IVIg), and autologous serum (AS) eyedrops in the treatment of the severe acute ocular complications of TEN. METHODS: A retrospective chart review of all patients admitted to the Burn Unit, Azienda Ospedaliero-Universitaria-Sassari, Sassari, Italy, from 2009 to 2015, identified 9 patients (2 men, 7 women; mean age 63...
March 21, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28352150/clinical-and-allergological-analysis-of-ocular-manifestations-of-sick-building-syndrome
#11
Yusuke Saeki, Kazuaki Kadonosono, Eiichi Uchio
PURPOSE: The disease concept of sick building syndrome (SBS) is still unclear. Ocular mucous membrane irritation is one of the major symptoms of SBS. However, the immunological aspects of the ocular complications of SBS are not yet clarified. The clinical and allergological aspects of SBS cases with ocular disorders with special reference to allergic conjunctival diseases (ACD) were analyzed, especially with respect to local immunological features. METHODS: Twelve cases of SBS with ocular findings and 49 cases of ACD (allergic conjunctivitis [AC], atopic keratoconjunctivitis [AKC], and vernal keratoconjunctivitis [VKC]) for comparison were evaluated...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28299439/vitamin-b12-deficiency-evaluation-and-treatment-in-severe-dry-eye-disease-with-neuropathic-ocular-pain
#12
Serkan Ozen, Murat Atabey Ozer, Mehmet Orçun Akdemir
PURPOSE: This study aims to understand the effect of vitamin B12 deficiency on neuropathic ocular pain (NOP) and symptoms in patients with dry eye disease (DED). METHODS: Patients with severe DED (without receiving topical artificial tears treatment) and ocular pain were enrolled (n = 90). Patients with severe DED and vitamin B12 deficiency (group 1, n = 45) received parenteral vitamin B12 supplement + topical treatment (artificial tears treatment + cyclosporine), and patients with severe DED and normal serum vitamin B12 level (group 2, n = 45) received only topical treatment (artificial tears treatment + cyclosporine)...
March 15, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28275666/data-representing-two-separate-lc-ms-methods-for-detection-and-quantification-of-water-soluble-and-fat-soluble-vitamins-in-tears-and-blood-serum
#13
Maryam Khaksari, Lynn R Mazzoleni, Chunhai Ruan, Robert T Kennedy, Adrienne R Minerick
Two separate liquid chromatography (LC)-mass spectrometry (MS) methods were developed for determination and quantification of water-soluble and fat-soluble vitamins in human tear and blood serum samples. The water-soluble vitamin method was originally developed to detect vitamins B1, B2, B3 (nicotinamide), B5, B6 (pyridoxine), B7, B9 and B12 while the fat-soluble vitamin method detected vitamins A, D3, 25(OH)D3, E and K1. These methods were then validated with tear and blood serum samples. In this data in brief article, we provide details on the two LC-MS methods development, methods sensitivity, as well as precision and accuracy for determination of vitamins in human tears and blood serum...
April 2017: Data in Brief
https://www.readbyqxmd.com/read/28245347/autologous-serum-eye-drops-for-dry-eye
#14
REVIEW
Qing Pan, Adla Angelina, Michael Marrone, Walter J Stark, Esen K Akpek
BACKGROUND: Theoretically, autologous serum eye drops (AS) offer a potential advantage over traditional therapies on the assumption that AS not only serve as a lacrimal substitute to provide lubrication but contain other biochemical components that allow them to mimic natural tears more closely. Application of AS has gained popularity as second-line therapy for patients with dry eye. Published studies on this subject indicate that autologous serum could be an effective treatment for dry eye...
February 28, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28212263/shoulder-synovial-fluid-lipoprotein-levels-and-their-relationship-to-the-rotator-cuff
#15
Daniel E Davis, Alexa Narzikul, Daniel Sholder, Mark Lazarus, Surena Namdari, Joseph Abboud
INTRODUCTION: Rotator cuff pathology has been proposed to occur through intrinsic and extrinsic mechanisms. Hyperlipidemia has been proposed as a mechanism of intrinsic rotator cuff pathology. This prospective observational study evaluates serum and synovial lipid profiles in patients with and without rotator cuff tears to further define the relationship of cholesterol and rotator cuff pathology. METHODS: Patients were prospectively enrolled with intact rotator cuff (37 patients) and rotator cuff tear requiring a repair (40 patients) groups...
March 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28184150/randomized-masked-in-vitro-comparison-of-three-commercially-available-tear-film-osmometers
#16
Guillermo Rocha, Eric Gulliver, Armand Borovik, Clara C Chan
PURPOSE: The purpose of this study was to compare the precision and accuracy of commercially available tear film osmometers. METHODS: Contrived tear solution target values representing the physiological range of tear osmolarity (normal eyes 297 mOsm/L, moderately dry eyes 342 mOsm/L, and severe dry eyes 383 mOsm/L) were constructed using a mix of mono- and divalent electrolytes, metabolites, serum albumin, and pH balanced to 7.4. Solution values were randomized and masked from the investigators during testing...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28182154/anterior-segment-findings-in-women-with-polycystic-ovary-syndrome
#17
Seda Karaca Adıyeke, Ibrahim Karaca, Suna Yıldırım, Mehmet Adıyeke, İbrahim Uyar, Gamze Türe
OBJECTIVES: This study aimed to investigate the anterior segment in women with polycystic ovary syndrome (PCOS) and to compare them with those of healthy reproductive-age female volunteers. MATERIALS AND METHODS: The study included 50 right eyes of 50 women with PCOS (group 1) and 50 right eyes of 50 healthy women (group 2). Intraocular pressure, Schirmer's test, tear film break-up time and central corneal thickness were evaluated in all subjects. Correlations between serum hormone (estradiol and testosterone) levels and observed findings were also investigated...
January 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28146241/meibomian-gland-physiology-in-pre-and-postmenopausal-women
#18
Tomo Suzuki, Yasuaki Minami, Aoi Komuro, Norihiko Yokoi, Shigeru Kinoshita
Purpose: The purpose of this study was to assess the change of meibomian gland physiology during the menstrual cycle and compare its physiology among pre- and postmenopausal women and men. Methods: This study involved 18 healthy subjects: 6 premenopausal women with a regular 28- to 30-day menstrual cycle, 6 postmenopausal women, and 6 men who were age-matched to the premenopausal women. All subjects measured basal body temperature every day at home and were seen once weekly for 5 weeks, and the menstrual state of the premenopausal subjects was masked until after the investigation...
February 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28139163/comparison-of-autologous-serum-versus-preservative-free-artificial-tear-in-patients-with-dry-eyes-due-to-systemic-isotretinoin-therapy
#19
Uğur Yılmaz, Erkut Küçük, Çağdaş Koç, Enes Gökler
PURPOSE: To investigate dry eye development in the patients receiving systemic retinoic acid therapy and to compare effectiveness of Autologous Serum (AS) and preservative free artificial tear (PFAT) in the patients with dry eye disease. METHOD: This prospective, crossover, double blind study was conducted on patients who have dry eyes due to systemic isotretinoin treatment for different indications. Patients detected as having dry eye during systemic isotretinoin treatment were included to our study...
January 31, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28129516/intra-articular-recombinant-human-proteoglycan-4-mitigates-cartilage-damage-after-destabilization-of-the-medial-meniscus-in-the-yucatan-minipig
#20
Kimberly A Waller, Kaitlyn E Chin, Gregory D Jay, Ling X Zhang, Erin Teeple, Scott McAllister, Gary J Badger, Tannin A Schmidt, Braden C Fleming
BACKGROUND: Lubricin, or proteoglycan 4 (PRG4), is a glycoprotein responsible for joint boundary lubrication. PRG4 has been shown previously to be down-regulated after traumatic joint injury such as a meniscal tear. Preliminary evidence suggests that intra-articular injection of PRG4 after injury will reduce cartilage damage in rat models of surgically induced posttraumatic osteoarthritis. OBJECTIVE: To determine the efficacy of intra-articular injection of full-length recombinant human lubricin (rhPRG4) for reducing cartilage damage after medial meniscal destabilization (DMM) in a preclinical large animal model...
January 1, 2017: American Journal of Sports Medicine
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