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https://www.readbyqxmd.com/read/29731797/the-association-between-ocular-problems-and-serum-testosterone-prolactin-and-thyroglobulin-concentrations-in-delayed-phase-of-sulfur-mustard-exposure
#1
Hassan Ghasemi, Nayere Askari, Sakine Moaiedmohseni, Soghrat Faghihzadeh, Susan Kabudanian Ardestani, Elham Faghihzadeh, Tooba Ghazanfari
Background and objective: Aside from direct toxic effects, Sulfur Mustard (SM) induced serum hormone abnormalities may aggravate ocular complaints, including Ocular Surface Discomfort (OSD) (burning, itching, and redness), dry eye sensation, photophobia, blurred vision, foreign body sensation, and pain. The aim of the current study was to investigate the possible association of ocular complaints with serum hormone concentrations in chronic phase of Sulfur Mustard (SM) exposure. Methods: As a part of Sardasht Iran Cohort Study (SICS), 372 SM-exposed patients and 128 non-exposed participants were enrolled...
2018: Iranian Journal of Pathology
https://www.readbyqxmd.com/read/29708819/impact-of-flow-rate-collection-devices-and-extraction-methods-on-tear-concentrations-following-oral-administration-of-doxycycline-in-dogs-and-cats
#2
Lionel Sebbag, Lucas Showman, Emily M McDowell, Ann Perera, Jonathan P Mochel
PURPOSE: Compare the precision of doxycycline quantification in tear fluid collected with either Schirmer strips or polyvinyl acetal (PVA) sponges following oral drug administration. METHODS: Three dogs and 3 cats were administered doxycycline orally at a dose of 4.2-5 mg/kg every 12 h for 6 consecutive days. At day 5 and 6, blood and tear fluid were sampled to capture doxycycline trough and maximal concentrations. Tear fluid was collected 3 times (spaced 10 min apart) at each session with the absorbent material placed in the lower conjunctival fornix until the 20-mm mark was reached (Schirmer strip, one eye) or for 1 min (PVA sponge, other eye)...
April 30, 2018: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29698813/neuropathic-keratopathy
#3
REVIEW
Harminder S Dua, Dalia G Said, Elisabeth M Messmer, Maurizio Rolando, Jose M Benitez-Del-Castillo, Parwez N Hossain, Alex J Shortt, Gerd Gerling, Mario Nubile, Francisco C Figueiredo, Saaeha Rauz, Leonardo Mastropasqua, Paolo Rama, Christophe Baudouin
Neurotrophic Keratopathy (NK) refers to a condition where corneal epitheliopathy leading to frank epithelial defect with or without stromal ulceration (melting) is associated with reduced or absent corneal sensations. Sensory nerves serve nociceptor and trophic functions, which can be affected independently or simultaneously. Loss of trophic function and consequent epithelial breakdown exposes the stroma making it susceptible to enzymatic degradation. Nerve pathology can range from attrition to aberrant re-generation with corresponding symptoms from anaesthesia to hyperaesthesia/allodynia...
April 23, 2018: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/29688286/endovascular-repair-of-thrombosed-type-acute-type-a-aortic-dissection-with-critical-renal-artery-malperfusion
#4
Atsushi Omura, Hitoshi Matsuda, Jiro Matsuo, Junjiro Kobayashi
An 81-year-old woman was referred to our centre for emergency surgery with a suspected diagnosis of acute aortic dissection. Laboratory tests showed marked elevation of serum creatinine and blood urea nitrogen. Enhanced computed tomography (CT) demonstrated Type A aortic dissection with a thrombosed false lumen in the ascending aorta. The primary entry tear was located 2 cm distal to the left subclavian artery. Malperfusion of bilateral renal arteries was also evident due to compression by the false lumen...
April 24, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29670328/treatment-outcomes-in-the-dry-eye-amniotic-membrane-dream-study
#5
Marguerite B McDonald, Hosam Sheha, Sean Tighe, Susan B Janik, Frank W Bowden, Amit R Chokshi, Michael A Singer, Seema Nanda, Mujtaba A Qazi, Damon Dierker, Adam T Shupe, Brittany J McMurren
Purpose: To evaluate the efficacy of cryopreserved amniotic membrane (CAM) in reducing signs and symptoms of dry eye disease (DED) in a large patient population. Methods: A retrospective chart review at 10 clinical sites was done of patients with refractory DED who received CAM and completed at least 3 months of follow-up. Data collected were demographics; medical history including previous and current ocular treatment, diagnosis, clinical presentations, comorbidity, duration and frequency of treatment with CAM; and concomitant medications...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29610453/sj%C3%A3-gren-s-syndrome-associated-with-fanconi-s-syndrome-and-osteomalacia
#6
Jorge O Gutierrez, Maria F Zurita, Luis A Zurita
BACKGROUND Sjögren's syndrome is a chronic inflammatory autoimmune disease, which is also known as sicca syndrome, due to the symptoms of dry eyes and dry mouth, and is associated with other connective tissue diseases and autoimmune diseases. Sjögren's syndrome can also be associated with renal involvement. Fanconi's syndrome is associated with impaired reabsorption in the proximal renal tubule associated with tubulointerstitial nephritis and is associated with renal tubular acidosis and hypophosphatemia...
April 3, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29602451/-autologous-serum-tears-long-term-treatment-in-dry-eye-syndrome
#7
M Beylerian, M Lazaro, J Magalon, J Veran, A Darque, F Grimaud, N Stolowy, H Beylerian, F Sabatier, L Hoffart
INTRODUCTION: Dry eye disease is a multifactorial pathology of the ocular surface. The high incidence of this pathology, as well as its significant impact on quality of life and vision and its financial cost, makes it a real public health problem. While the treatment of mild cases is generally simple and effective, treatment of severe forms is often disappointing. The use of autologous serum tears (AST) represents a therapeutic alternative for the most severe cases. The purpose of our study is to evaluate the efficacy of long-term AST treatment in patients with severe dry eye disease refractory to conventional treatment or secondary to systemic diseases such as Sjögren's syndrome or Graft versus Host disease (GVH), or ocular pathologies such as neurotrophic keratitis, chemical burns and ocular cicatricial pemphigoid...
March 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29527528/reflections-on-dry-eye-syndrome-treatment-therapeutic-role-of-blood-products
#8
REVIEW
Victor J Drew, Ching-Li Tseng, Jerard Seghatchian, Thierry Burnouf
Dry eye syndrome (DES) is a multifactorial, frequent, pathology characterized by deficient tear production or increased evaporation of tears and associated with ocular surface alteration and inflammation. It mostly affects, but not exclusively, older individuals and leads to varying degrees of discomfort and decreased quality of life. Although the typical treatments of DES rely on using artificial tears, polyunsaturated fatty acids, integrin antagonists, anti-inflammatory agents, or on performing punctal occlusion, recently, standardized blood-derived serum eye drops (SED) are generating much interest as a new physiological treatment option...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29490661/effect-of-tear-collection-on-lacrimal-total-protein-content-in-dogs-and-cats-a-comparison-between-schirmer-strips-and-ophthalmic-sponges
#9
Lionel Sebbag, Emily M McDowell, Patrick M Hepner, Jonathan P Mochel
BACKGROUND: Quantification of lacrimal total protein content (TPC) is an important tool for clinical scientists to understand disease pathogenesis, identify potential biomarkers and assess response to therapy, among other applications. However, TPC is not only affected by disease state but also by the method used for tear collection. Thus, the purpose of this study is to determine the impact on TPC of two methods of tear collection in dogs and cats: Schirmer strips and polyvinyl acetal (PVA) sponges...
March 1, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29476504/mass-spectrometric-identification-of-endogenous-peptides
#10
Mikel Azkargorta, Iraide Escobes, Ibon Iloro, Felix Elortza
Peptidomics is an emerging field focused in the analysis of endogenous peptides. Naturally occurring peptides are often endogenously produced protein fragments. Cleavage of precursor proteins by proteases generates peptides that may gain specialized functions not ascribed to their precursors, and which could reflect the state of a cell under certain physiological conditions or pathological processes.Since peptides are found in complex matrices (e.g., serum, tear, urine, cerebrospinal fluid), they need to be isolated from the matrix and concentrated before they can be analyzed on mass spectrometry...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29470971/use-of-autologous-serum-tears-for-the-treatment-of-ocular-surface-disease-from-patients-with-systemic-autoimmune-diseases
#11
Tayyeba K Ali, Allister Gibbons, Cristián Cartes, Siamak Zarei-Ghanavati, Mohamed Gomaa, Ingrid Gonzalez, Astrid E Gonzalez, Hilal E Ozturk, Carolina Betancurt, Victor L Perez
PURPOSE: To describe the safety and efficacy of autologous serum tears (AST) in managing ocular surface disease resistant to conventional therapy in patients with systemic autoimmune disease(s). DESIGN: Retrospective, interventional case series. METHODS: Records of patients from 2009 to 2015 with systemic autoimmune disease treated with AST (20%-50%) for chronic surface disease were analyzed. Standardized measures of subjective dry eye symptoms, objective dry eye staining of the cornea, and slit-lamp findings including punctate epithelial erosion (PEE), filamentary keratopathy (FK), and corneal epithelial defects (KED) were compared during first and last visit...
May 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29455281/sensitive-colorimetric-assay-for-uric-acid-and-glucose-detection-based-on-multilayer-modified-paper-with-smartphone-as-signal-readout
#12
Xu Wang, Fang Li, Ziqi Cai, Kaifan Liu, Jing Li, Boyang Zhang, Jianbo He
In this work, a multilayer-modified paper-based colorimetric sensing platform with improved color uniformity and intensity was developed for the sensitive and selective determination of uric acid and glucose with smartphone as signal readout. In detail, chitosan, different kinds of chromogenic reagents, and horseradish peroxidase (HRP) combined with a specific oxidase, e.g., uricase or glucose oxidase (GOD), were immoblized onto the paper substrate to form a multilayer-modified test paper. Hydrogen peroxide produced by the oxidases (uricase or GOD) reacts with the substrates (uric acid or glucose), and could oxidize the co-immoblized chromogenic reagents to form colored products with HRP as catalyst...
April 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29439091/evaluation-of-galectin-1-and-galectin-3-as-prospective-biomarkers-in-keratoconus
#13
Frans Eberth Costa Andrade, Joyce Luciana Covre, Lisandra Ramos, Rossen Mihaylov Hazarbassanov, Myrna Serapião Dos Santos, Mauro Campos, José Álvaro Pereira Gomes, Cristiane Damas Gil
AIMS: To evaluate the expression of β-galactoside-binding proteins galectin (Gal)-1 and Gal-3 in patients with keratoconus (KC) and postcorneal collagen cross-linking (CXL) treatment in vitro. METHODS: Tear fluid, cornea samples and conjunctival impression cytology specimens from control and KC patients were used to evaluate Gal-1 and Gal-3 expressions. Primary keratocytes were isolated by collagenase digestion from surgically removed corneas of five normal or KC human corneal buttons and cultured in Dulbecco's modified eagle medium/Ham's F12 medium supplemented with 2% fetal bovine serum...
May 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29436757/microstructured-photo-crosslinked-poly-trimethylene-carbonate-for-use-in-soft-lithography-applications-a-biodegradable-alternative-for-poly-dimethylsiloxane
#14
Sigrid Schüller-Ravoo, Sandra M Teixeira, Bernke Papenburg, Dimitrios Stamatialis, Jan Feijen, Dirk W Grijpma
Photo-crosslinkable poly(trimethylene carbonate) (PTMC) macromers were used to fabricate microstructured surfaces. Microstructured PTMC surfaces were obtained by hot embossing the macromer against structured silicon masters and subsequent photo-crosslinking, resulting in network formation. The microstructures of the master could be precisely replicated, limiting the shrinkage. Microstructured PTMC was investigated for use in two different applications: as stamping material to transfer a model protein to another surface and as structured substrate for cell culture...
February 13, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/29427020/-autoimmunity-and-glaucoma
#15
REVIEW
K Bell, S Funke, F H Grus
In addition to the clinically most relevant risk factor for glaucoma, i.e., elevated intraocular pressure (IOP), there are other factors with high relevance for the disease. Changes in the autoimmune component of the immune system are of particular importance. Clinical studies have demonstrated alterations in different autoantibodies in glaucoma patients compared to healthy controls, some of which increase in abundance/have a raised titer, but also some which have a reduced titer. These changes have a distinct potential-not only as a tool for early glaucoma detection, but also as a therapeutic option due to the documented neuroprotective effects of some of these antibodies...
February 9, 2018: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/29423024/a-novel-multiplex-detection-array-revealed-systemic-complement-activation-in-oral-squamous-cell-carcinoma
#16
Juliane Gallenkamp, Gerrit Spanier, Elisabeth Wörle, Markus Englbrecht, Michael Kirschfink, Roman Greslechner, Regine Braun, Nicole Schäfer, Richard J Bauer, Diana Pauly
Oral squamous cell carcinoma (OSCC) is one of the most common tumors within the oral cavity. Early diagnosis and prognosis tools are urgently needed. This study aimed to investigate the activation of the complement system in OSCC patients as potential biomarker. Therefore, an innovative complement activation array was developed. Characterized antibodies detecting the complement activation specific epitopes C3a, C5a and sC5b-9 along with control antibodies were implemented into a suspension bead array. Human serum from a healthy ( n = 46) and OSCC patient ( n = 57) cohort were used to investigate the role of complement activation in oral tumor progression...
January 9, 2018: Oncotarget
https://www.readbyqxmd.com/read/29422859/successful-subcutaneous-allergen-specific-immunotherapy-in-refractory-atopic-keratoconjunctivitis-a-case-report
#17
Passara Jongkhajornpong, Wannada Laisuan
Purpose: We report a case of refractory atopic keratoconjunctivitis (AKC) which was successfully treated with subcutaneous immunotherapy (SCIT). Case Report: A 22-year-old woman presented with severe allergic conjunctivitis for one and a half year. She failed to respond to conventional topical anti-allergic medications, topical corticosteroid, as well as topical cyclosporine A. Therefore, oral corticosteroids had to be prescribed to control the exacerbation for 1 year...
September 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29370030/beta-d-glucan-testing-in-patients-with-fungal-endophthalmitis
#18
Anton M Kolomeyer, Kathleen M Murphy, Anastasia Traband, Ian Frank, Benjamin J Kim
PURPOSE: To review the literature on beta-D-glucan (BDG) testing in fungal endophthalmitis. METHODS: Review of primary literature using PubMed through April 2017 and presentation of an illustrative case report. A total of 231 articles were identified and 43 were ultimately chosen for review based on relevance and presence of ophthalmologic examination and objective data. RESULTS: Beta-D-glucan is a major component of fungal cell walls. It is quantified using a calorimetry-based Fungitell assay based on modification of the limulus amebocyte lysate...
April 2018: Retina
https://www.readbyqxmd.com/read/29343478/treatment-of-gastrointestinal-bleeding-with-idarucizumab-in-a-patient-receiving-dabigatran
#19
Jennifer Mourafetis, Norman Doctor, Simon Leung
PURPOSE: A case report describing use of idarucizumab for dabigatran reversal without the use of hemostatic agents in a patient who developed acute upper gastrointestinal (GI) bleeding while receiving triple antithrombotic therapy is presented. SUMMARY: A 77-year-old man with a complex cardiac history presented to the emergency room with chief complaints of black tarry stools and low blood pressures for 4 days. His past medical history included recent percutaneous coronary intervention (PCI) and drug-eluting stent (DES) placement, atrial fibrillation, hypertension, hyperlipidemia, coronary artery disease, coronary artery bypass graft surgery, stage 3 chronic kidney disease, and cholecystectomy...
February 15, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29337026/effect-of-recombinant-human-growth-hormone-on-rotator-cuff-healing-after-arthroscopic-repair-preliminary-result-of-a-multicenter-prospective-randomized-open-label-blinded-end-point-clinical-exploratory-trial
#20
Joo Han Oh, Seok Won Chung, Kyung-Soo Oh, Jae Chul Yoo, Wonhee Jee, Jung-Ah Choi, Yang-Soo Kim, Jin-Young Park
BACKGROUND: This study evaluated the effect of systemic injection of recombinant human growth hormone (rhGH) on outcomes after arthroscopic rotator cuff repair. METHODS: This multicenter, prospective, randomized, comparative trial, randomized patients who underwent arthroscopic repair of large-sized rotator cuff tears into 3 groups: rhGH 4 mg group (n = 26), rhGH 8 mg group (n = 24) , and control group (n = 26). Sustained release rhGH was injected subcutaneously once weekly for 3 months postoperatively...
January 11, 2018: Journal of Shoulder and Elbow Surgery
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