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https://www.readbyqxmd.com/read/29164949/local-pro-inflammatory-cytokine-and-nitric-oxide-responses-are-elevated-in-patients-with-pterygium
#1
S Zidi, F Bediar-Boulaneb, H Belguendouz, M Belkhelfa, O Medjeber, O Laouar, C Henchiri, C Touil-Boukoffa
Pterygium is a common ocular surface disease observed in humans. Chronic ultraviolet (UV) exposure is extensively recognized as an aetiological factor in the pathogenesis of this disease. This hypothesis is sustained by epidemiological and histopathological data in relation to UV injured skin. Although some findings have indicated that genetic factors, anti-apoptotic and immunological mechanisms are involved in the pathogenesis of pterygium, the mechanism by which it develops remains poorly understood. In this study, we analysed the in vivo production of IL-17A, IL-6, IL-10 and nitric oxide (NO) in the tears and sera from Algerian patients...
November 1, 2017: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/29158874/mitochondria-targeted-antioxidant-skq1-prevents-anesthesia-induced-dry-eye-syndrome
#2
Evgeni Yu Zernii, Olga S Gancharova, Viktoriia E Baksheeva, Marina O Golovastova, Ekaterina I Kabanova, Marina S Savchenko, Veronika V Tiulina, Larisa F Sotnikova, Andrey A Zamyatnin, Pavel P Philippov, Ivan I Senin
Dry eye syndrome (DES) is an age-related condition increasingly detected in younger people of risk groups, including patients who underwent ocular surgery or long-term general anesthesia. Being a multifactorial disease, it is characterized by oxidative stress in the cornea and commonly complicated by ocular surface inflammation. Polyetiologic DES is responsive to SkQ1, a mitochondria-targeted antioxidant suppressing age-related changes in the ocular tissues. Here, we demonstrate safety and efficacy of topical administration of SkQ1 at a dosage of 7...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29156634/an-overview-of-chitosan-nanoparticles-and-its-application-in-non-parenteral-drug-delivery
#3
REVIEW
Munawar A Mohammed, Jaweria T M Syeda, Kishor M Wasan, Ellen K Wasan
The focus of this review is to provide an overview of the chitosan based nanoparticles for various non-parenteral applications and also to put a spotlight on current research including sustained release and mucoadhesive chitosan dosage forms. Chitosan is a biodegradable, biocompatible polymer regarded as safe for human dietary use and approved for wound dressing applications. Chitosan has been used as a carrier in polymeric nanoparticles for drug delivery through various routes of administration. Chitosan has chemical functional groups that can be modified to achieve specific goals, making it a polymer with a tremendous range of potential applications...
November 20, 2017: Pharmaceutics
https://www.readbyqxmd.com/read/29155856/treatment-with-solubilized-silk-derived-protein-sdp-enhances-rabbit-corneal-epithelial-wound-healing
#4
Waleed Abdel-Naby, Brigette Cole, Aihong Liu, Jingbo Liu, Pengxia Wan, Ryan Schreiner, David W Infanger, Nicholas B Paulson, Brian D Lawrence, Mark I Rosenblatt
There is a significant clinical need to improve current therapeutic approaches to treat ocular surface injuries and disease, which affect hundreds of millions of people annually worldwide. The work presented here demonstrates that the presence of Silk-Derived Protein (SDP) on the healing rabbit corneal surface, administered in an eye drop formulation, corresponds with an enhanced epithelial wound healing profile. Rabbit corneas were denuded of their epithelial surface, and then treated for 72-hours with either PBS or PBS containing 5 or 20 mg/mL SDP in solution four times per day...
2017: PloS One
https://www.readbyqxmd.com/read/29150990/prevalence-of-dry-eye-disease-and-its-association-with-dyslipidemia
#5
Krishnamoorthy Rathnakumar, Kaliaperumal Ramachandran, Durairaj Baba, Venkatachalam Ramesh, Velusamy Anebaracy, Ramachandran Vidhya, Rajamanickam Vinothkumar, Ramamurthy Poovitha, Rajagopalan Geetha
BACKGROUND: Dry eye disease (DED) is a common ocular surface disease significantly affecting the quality of life of patients. The aim of our study is to focus on the prevalence of DED and to determine the relationship between dyslipidemia and DED. METHODS: The study was performed with the age group of 25-70 years, who attended the ophthalmology outpatient department at Sri Lakshmi Narayana Institute of Medical Sciences with complaints of dry eye. A standard questionnaire was taken, and tear film tests were performed to diagnose dry eye...
November 18, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29150029/-fungal-keratitis
#6
REVIEW
T Bourcier, A Sauer, A Dory, J Denis, M Sabou
Fungal keratitis, or keratomycoses, are corneal infections which must be considered in cases of corneal trauma, prior corneal surgery, chronic ocular surface disease, topical corticosteroids or contact lens wear. Filamentous fungi or yeasts may be involved. Presenting clinical features such as corneal infiltrates with feathery edges and/or raised surface, intact epithelium with deep stromal involvement, satellite lesions, endothelial plaques, lack of improvement with antibiotics and worsening with steroids are suggestive of fungal keratitis...
November 14, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29148532/the-royal-college-of-ophthalmologists-guidelines-on-serum-eye-drops-for-the-treatment-of-severe-ocular-surface-disease-full-report
#7
S Rauz, S-Y Koay, B Foot, S B Kaye, F Figueiredo, M A Burdon, E Dancey, A Chandrasekar, R Lomas
No abstract text is available yet for this article.
November 17, 2017: Eye
https://www.readbyqxmd.com/read/29148531/the-royal-college-of-ophthalmologists-guidelines-on-serum-eye-drops-for-the-treatment-of-severe-ocular-surface-disease-executive-summary
#8
S Rauz, S-Y Koay, B Foot, S B Kaye, F Figueiredo, M A Burdon, E Dancey, A Chandrasekar, R Lomas
No abstract text is available yet for this article.
November 17, 2017: Eye
https://www.readbyqxmd.com/read/29144869/ocular-redness-measured-with-the-keratograph-5m-in-patients-using-anti-glaucoma-eye-drops
#9
Francisco Pérez Bartolomé, Jose María Martínez de la Casa, Pedro Arriola Villalobos, Cristina Fernández Pérez, Vicente Polo, Ruben Sánchez Jean, Julián García Feijoó
PURPOSE: To examine correlations between ocular redness measured with the new topographer Keratograph 5M and the use of topical anti-glaucoma medication. METHODS: A total of 211 eyes of 211 patients with open-angle glaucoma or ocular hypertension on topical medication and 51 eyes of 51 healthy volunteers were recruited over 10 months. Outcome variables were keratograph redness scores (RS): overall, bulbar temporal (BT), bulbar nasal (BN), limbar temporal (LT), and limbar nasal (LN)...
November 16, 2017: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/29140823/single-center-retrospective-study-on-meibomian-gland-loss-in-patients-with-ocular-chronic-graft-versus-host-disease
#10
Lijuan Que, Xiaofeng Zhang, Mengmeng Li
OBJECTIVES: This study aimed to analyze the influencing factors of meibomian gland loss in patients with ocular chronic graft-versus-host disease (GVHD) and its correlation with other clinical ocular surface assessment indexes. METHODS: The clinical data of patients with ocular chronic GVHD from the ocular surface and corneal outpatient clinic of the First Affiliated Hospital of Soochow University were reviewed from June 2012 to June 2016. The relationship between the percentage of meibomian gland acinar area and the influencing factors, such as patient's sex, age, transplantation method, human leukocyte antigen (HLA) matching, the time when eye discomfort appeared after transplantation (month), and the severity of ocular chronic GVHD, was investigated...
November 14, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/29135738/efficacy-of-rebamipide-instillation-for-contact-lens-discomfort-with-dry-eye
#11
Tsutomu Igarashi, Maika Kobayashi, Chiemi Yaguchi, Chiaki Fujimoto, Hisaharu Suzuki, Hiroshi Takahashi
OBJECTIVE: To examine the effects of rebamipide ophthalmic solution on the symptoms, signs, and cytokine concentrations in tear fluid among soft contact lens (SCL) wearers with Dry eye disease (DED). METHODS: From November 2015 to June 2017, this open-label, single-arm study examined 40 eyes of 20 SCL wearers with DED who had been using daily disposable SCLs for >3 months (mean age, 30.0±8.33 years; range, 20-47 years). Signs, symptoms, and cytokine concentrations were assessed before and 4 weeks after starting 2% rebamipide ophthalmic solution 4 times/day...
November 10, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/29135602/ocular-surface-alterations-in-the-context-of-corneal-in-vivo-confocal-microscopic-characteristics-in-patients-with-fibromyalgia
#12
Kadriye Erkan Turan, Sibel Kocabeyoglu, Isin Unal-Cevik, Figen Bezci, Aysen Akinci, Murat Irkec
PURPOSE: To quantify the morphology of corneal basal epithelium and subbasal nerves and to evaluate the ocular surface alterations in patients with fibromyalgia (FM). METHODS: Patients with FM (n = 34) and healthy controls (n = 42) were enrolled. All participants underwent ocular surface tests in the following order: corneal sensitivity, tear film breakup time, lissamine green staining, Schirmer test, and the Ocular Surface Disease Index questionnaire. Basal epithelial cells and subbasal nerves were evaluated using in vivo confocal microscopy (IVCM)...
November 9, 2017: Cornea
https://www.readbyqxmd.com/read/29134276/-novel-current-and-future-therapy-options-for-treatment-of-dry-eye-disease
#13
REVIEW
E M Messmer
Dry eye disease was redefined by the dry eye workshop (DEWS II) in May 2017. According to the new definition "dry eye is a multifactorial disease of the ocular surface characterized by a loss of homeostasis of the tear film and accompanied by ocular symptoms". The current definition encompasses etiological factors, such as instability and hyperosmolarity of the tear film, ocular surface inflammation and damage as well as a new aspect compared to the former definition, neurosensory abnormalities. Recent and future therapeutic options for dry eye focus on treatment of the aforementioned pathogenetic events...
November 13, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/29126993/trophic-effect-of-pacap-on-human-corneal-endothelium
#14
Grazia Maugeri, Antonio Longo, Agata Grazia D'Amico, Daniela Maria Rasà, Michele Reibaldi, Andrea Russo, Vincenza Bonfiglio, Teresio Avitabile, Velia D'Agata
Cornea's posterior surface includes endothelium maintaining stromal hydration and clarity. Due to their limited proliferative capability, the loss of endothelial cells can outcome in permanent opacity. In the last years, different studies have demonstrated the protective effect of pituitary adenylate cyclase-activating polypeptide (PACAP) in different ocular diseases. However, its role on human corneal endothelial cells (HCECs) has not been investigated, yet. Here, we have developed a culture protocol to differentiate HCECs from donor's cornea...
November 8, 2017: Peptides
https://www.readbyqxmd.com/read/29115899/therapeutic-inhibitors-for-the-treatment-of-dry-eye-syndrome
#15
Candela Rodríguez-Pomar, Jesus Pintor, Basilio Colligris, Gonzalo Carracedo
Dry eye disease (DED), defined as a multifactorial disease of tears and ocular surface, results in symptoms of discomfort, ocular irritation, visual disturbance and tear film instability. This syndrome is accompanied of ocular surface inflammation and it is produced by a deficient activity of the lacrimal functional unit. In addition, it is associated with systemic autoimmune diseases such as Sjögren´s Syndrome, rheumatoid arthritis, systemic lupus erythematosus and some drug administration. The treatment of dry eye disease is based on the typical signs and symptoms of dry eye, which are associated with hyperosmolarity, ocular surface inflammation, discomfort, visual disturbance, and tear film instability...
November 14, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29113918/the-impact-of-diabetes-on-corneal-nerve-morphology-and-ocular-surface-integrity
#16
REVIEW
Maria Markoulli, Judith Flanagan, Shyam Sunder Tummanapalli, Jenny Wu, Mark Willcox
Diabetes mellitus is a chronic disease that results from inadequate insulin production or ineffective insulin utilization. It is one of the most common systemic diseases worldwide with increasing prevalence. Diabetes mellitus is associated with premature mortality, macrovascular complications such as cardiovascular disease, and microvascular complications, including nephropathy leading to kidney failure, potentially blinding diabetic retinopathy, and diabetic neuropathy. While the retinal complications of diabetes are well recognized by eye care professionals, the effects on the ocular surface are poorly understood...
November 4, 2017: Ocular Surface
https://www.readbyqxmd.com/read/29112493/-cysteamine-ophthalmic-hydrogel-for-the-treatment-of-ocular-cystinosis
#17
Anxo Fernández-Ferreiro, Andrea Luaces-Rodríguez, Victoria Díaz-Tomé, María Gil-Martínez, María Teresa Rodríguez Ares, Rosario Touriño Peralba, José Blanco-Méndez, Miguel González-Barcia, Francisco Javier Otero-Espinar, María Jesús Lamas
Ocular cystinosis is a rare disease characterised by the deposit of cystine crystals on the corneal surface, which hinder patients' eyesight. Oral cysteamine is given as cysteamine; however, it does not reach the cornea due to the lack of corneal vascularization making necessary its  administration by the topical ocular route. The aim of the present study is to  determine the stability of an ophthalmic hydrogel of cysteamine, which can be  potentially prepared at hospital pharmacy departments, under different preservation conditions during a follow-up of 30 days...
November 1, 2017: Farmacia Hospitalaria
https://www.readbyqxmd.com/read/29111817/structural-ultrastructural-and-morphometric-study-of-the-zebrafish-ocular-surface-a-model-for-human-corneal-diseases
#18
Domenico Puzzolo, Antonina Pisani, Consuelo Malta, Giuseppe Santoro, Alessandro Meduri, Francesco Abbate, Giuseppe Montalbano, Edward Wylegala, Rosa Alba Rana, Fabio Bucchieri, Antonio Ieni, Pasquale Aragona, Antonio Micali
PURPOSE: A morphological and morphometric study of the adult zebrafish ocular surface was performed to provide a comprehensive description of its parts and to evaluate its similarity to the human. MATERIALS AND METHODS: The eyes of adult zebrafish were processed for light, transmission and scanning electron microscopy, and for immunohistochemical stain of corneal nerves; a morphometric analysis was also performed on several morphological parameters. RESULTS: The corneal epithelium was formed by five layers of cells...
November 7, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29110603/characterization-of-polyethersulfone-membranes-for-tear-fluid-collection
#19
Q Yang, X Liu, Z Song, L Lin, K Wu
This study evaluated the utility of polyethersulfone membranes (PESms) for tear collection and compared it with two frequently employed approaches: the use of Schirmer test paper (STP) and capillary tube (CaT). STP and PESms of 0.45 and 0.65 μm (PESm65) were examined using scanning electron microscopy (SEM), applied to soak up water and cellular lysates, and employed to collect tear fluid (TF) from rabbits. The proteins in the cellular lysates and TF were characterized through band profiling of SDS-polyacrylamide electrophoresis (PAGE) gels and Western blot analyzing...
November 1, 2017: Current Molecular Medicine
https://www.readbyqxmd.com/read/29110189/ciclosporin-ophthalmic-emulsion-0-1-a-review-in-severe-dry-eye-disease
#20
Sheridan M Hoy
Ciclosporin ophthalmic emulsion 0.1% (hereafter referred to as ciclosporin 0.1%) [Ikervis(®)] is an unpreserved cationic emulsion formulation containing an 0.1% concentration of ciclosporin. It has been approved in various countries worldwide, including those of the EU, for the treatment of severe keratitis in adults with dry eye disease, which has not improved despite treatment with tear substitutes. In a multinational, phase III study in this patient population, once-daily ciclosporin 0.1% was associated with statistically significant and clinically relevant improvements in the signs (corneal surface damage and ocular surface inflammation) of dry eye disease relative to vehicle during the first 6-month treatment period...
November 2017: Drugs
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