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cancer noncoding RNA

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https://www.readbyqxmd.com/read/27905400/lncbrm-initiates-yap1-signalling-activation-to-drive-self-renewal-of-liver-cancer-stem-cells
#1
Pingping Zhu, Yanying Wang, Jiayi Wu, Guanling Huang, Benyu Liu, Buqing Ye, Ying Du, Guangxia Gao, Yong Tian, Lei He, Zusen Fan
Liver cancer stem cells (CSCs) may contribute to the high rate of recurrence and heterogeneity of hepatocellular carcinoma (HCC). However, the biology of hepatic CSCs remains largely undefined. Through analysis of transcriptome microarray data, we identify a long noncoding RNA (lncRNA) called lncBRM, which is highly expressed in liver CSCs and HCC tumours. LncBRM is required for the self-renewal maintenance of liver CSCs and tumour initiation. In liver CSCs, lncBRM associates with BRM to initiate the BRG1/BRM switch and the BRG1-embedded BAF complex triggers activation of YAP1 signalling...
December 1, 2016: Nature Communications
https://www.readbyqxmd.com/read/27904771/tumor-suppressive-function-of-long-noncoding-rna-malat1-in-glioma-cells-by-suppressing-mir-155-expression-and-activating-fbxw7-function
#2
Shuanzhu Cao, Yanzhou Wang, Jinquan Li, Mingliang Lv, Haitao Niu, Yong Tian
The human metastasis associated lung adenocarcinoma transcript 1 (MALAT1) is a long non-coding RNA associated with metastasis, and is a favorable prognostic factor for lung cancer. Recent studies have shown that MALAT1 plays an important role in many malignancies. However, little is known about the role of MALAT1 in glioma. In this study, we determined the expression of MALAT1 and explored its prognostic value in glioma. Further, we investigated the regulatory mechanism of MALAT1 in glioma progression. Our results showed that the expression of MALAT1 was significantly decreased in glioma specimens than in noncancerous brain tissues...
2016: American Journal of Cancer Research
https://www.readbyqxmd.com/read/27900563/lncrna-hotair-promotes-cisplatin-resistance-in-gastric-cancer-by-targeting-mir-126-to-activate-the-pi3k-akt-mrp1-genes
#3
Jin Yan, Yini Dang, Shiyu Liu, Yifeng Zhang, Guoxin Zhang
Altered expression of long noncoding RNAs (lncRNAs) has shown to associate with human cancer development and progression and drug resistance. LncRNA HOX antisense intergenic RNA (HOTAIR) regulates chromatin state and highly expressed in various human cancers. This study analyzed HOTAIR expression in gastric cancer cells and tissues and then assessed the effects of HOTAIR on modulation of gastric cancer cell sensitivity to cisplatin and the underlying molecular events. The data showed that HOTAIR was significantly upregulated in cisplatin-resistant gastric cancer cells and tissues compared with control cells and noncancerous gastric tissues...
November 30, 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/27899822/mir-150-exerts-antileukemia-activity-in-vitro-and-in-vivo-through-regulating-genes-in-multiple-pathways
#4
Zhi Hong Fang, Si Li Wang, Jin Tao Zhao, Zhi Juan Lin, Lin Yan Chen, Rui Su, Si Ting Xie, Bing Z Carter, Bing Xu
MicroRNAs, a class of small noncoding RNAs, have been implicated to regulate gene expression in virtually all important biological processes. Although accumulating evidence demonstrates that miR-150, an important regulator in hematopoiesis, is deregulated in various types of hematopoietic malignancies, the precise mechanisms of miR-150 action are largely unknown. In this study, we found that miR-150 is downregulated in samples from patients with acute lymphoblastic leukemia, acute myeloid leukemia, and chronic myeloid leukemia, and normalized after patients achieved complete remission...
September 22, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27897239/expression-level-and-clinical-significance-of-hox-transcript-antisense-intergenic-rna-in-cervical-cancer-a-meta-analysis
#5
Shasha Liu, Min Zhang, Pengpeng Qu
The long noncoding RNA HOX transcript antisense intergenic RNA (HOTAIR) is associated with the development and progression of several types of cancer; however, its role in cervical cancer is unclear. Here, we performed a meta-analysis to evaluate the expression levels and clinical significance of HOTAIR in cervical cancer tissue. Relevant literature published by January 2016 was identified in PubMed, EMBase, National Knowledge Infrastructure, Wanfang Database, and Chinese Biomedical Literature Database. We performed statistical analysis, calculated standard mean differences (SMDs), and determined combined odds ratios (ORs) with 95% confidence intervals...
November 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27896272/long-noncoding-rna-let-suppresses-tumor-growth-and-emt-in-lung-adenocarcinoma
#6
Bin Liu, Chun-Feng Pan, Zhi-Cheng He, Jun Wang, Peng-Li Wang, Teng Ma, Yang Xia, Yi-Jiang Chen
Recently, many studies showed that long noncoding RNAs (lncRNAs) are involved in tumor progression. It is reported that lncRNA-LET is downregulated and has antitumor effect on several types of cancer. This study focuses on the role of lncRNA-LET on lung adenocarcinoma (LAC) progression. RT-PCR results indicated that frequent downregulation of lncRNA-LET in LAC tissues was related to clinicopathologic factors. lncRNA-LET knockdown significantly promoted LAC cell proliferation, invasion, and migration while lncRNA-LET overexpression obviously inhibited LAC cell proliferation, invasion, and migration, indicating a tumor inhibition of lncRNA-LET in LAC progression...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27896271/expression-and-clinical-significance-of-the-novel-long-noncoding-rna-znf674-as1-in-human-hepatocellular-carcinoma
#7
Lufei Zhang, Tianyu He, Yingcai Yan, Yuan Zhang, Xiaohu Zhou, Pengfei Huang, Yang Kong, Minjie Xie, Linshi Zhang, Qiang Sun, Dongkai Zhou, Haiyang Xie, Lin Zhou, Shusen Zheng, Weilin Wang
Long noncoding RNAs (lncRNAs) play crucial roles in cancer occurrence and progression. However, the relationship between the expression levels of lncRNAs and the hepatocellular carcinoma (HCC) process is unclear. The goal of this study was to determine the expression level of ZNF674-AS1, a newly found lncRNA, in HCC and its clinical association. The expression of ZNF674-AS1 in 137 pairs of tumorous and adjacent normal tissues from patients with HCC was detected by quantitative real-time reverse transcription polymerase chain reaction...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27888803/exosomal-long-noncoding-rna-crnde-h-as-a-novel-serum-based-biomarker-for-diagnosis-and-prognosis-of-colorectal-cancer
#8
Tong Liu, Xin Zhang, Shanyu Gao, Fangmiao Jing, Yongmei Yang, Lutao Du, Guixi Zheng, Peilong Li, Chen Li, Chuanxin Wang
Cancer-secreted long non-coding RNAs (lncRNAs) are emerging mediators of cancer-host cross talk. The aim of our study was to illustrate the clinical significance of the lncRNA CRNDE-h in exosomes purified from the serum of patients with colorectal cancer (CRC). The study was divided into four parts: (1) The exosome isolated methods and lncRNA detected methods which accurately and reproducibly measure CRC-related exosomal CRNDE-h in serum were optimized in preliminary pilot stage; (2) The stability of exosomal CRNDE-h was evaluated systematically; (3) The origin of exosomal CRNDE-h was explorated in vitro and in vivo; (4) The diagnostic and prognostic value of exosomal CRNDE-h for CRC were validated in 468 patients...
November 19, 2016: Oncotarget
https://www.readbyqxmd.com/read/27888635/lncrnas-the-bridge-linking-rna-and-colorectal-cancer
#9
Yanfei Yang, Linjie Zhao, Lingzi Lei, Wayne Bond Lau, Bonnie Lau, Qilian Yang, Xiaobing Le, Huiliang Yang, Chenlu Wang, Zhongyue Luo, Yu Xuan, Yi Chen, Xiangbing Deng, Lian Xu, Min Feng, Tao Yi, Xia Zhao, Yuquan Wei, Shengtao Zhou
Long noncoding RNAs (lncRNAs) are transcribed by genomic regions (exceeding 200 nucleotides in length) that do not encode proteins. While the exquisite regulation of lncRNA transcription can provide signals of malignant transformation, lncRNAs control pleiotropic cancer phenotypes through interactions with other cellular molecules including DNA, protein, and RNA. Recent studies have demonstrated that dysregulation of lncRNAs is influential in proliferation, angiogenesis, metastasis, invasion, apoptosis, stemness, and genome instability in colorectal cancer (CRC), with consequent clinical implications...
November 24, 2016: Oncotarget
https://www.readbyqxmd.com/read/27885842/crucial-role-of-noncoding-rna-in-driving-prostate-cancer-development-and-progression
#10
Haiyang Guo, Musaddeque Ahmed, Junjie Hua, Fraser Soares, Housheng Hansen He
No abstract text is available yet for this article.
November 25, 2016: Epigenomics
https://www.readbyqxmd.com/read/27878359/long-noncoding-rna-gas5-inhibits-malignant-proliferation-and-chemotherapy-resistance-to-doxorubicin-in-bladder-transitional-cell-carcinoma
#11
Hui Zhang, Yan Guo, Yongsheng Song, Chao Shang
PURPOSE: Bladder cancer is the most general malignant cancer in genitourinary system, more than 90% of BCs are bladder transitional cell carcinomas (BTCC). This study aimed to investigate the clinical significance of growth arrest-specific 5 (GAS5) gene and its regulatory effects of malignant proliferation and chemotherapy resistance to doxorubicin in BTCC cells. METHODS: The expression of GAS5 was detected by quantitative real-time PCR. Statistical analysis was used to determine the relationship between GAS5 expression and clinical features and the prognostic value of GAS5 for disease free survival...
November 22, 2016: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/27875818/the-expression-of-ccat2-a-novel-long-noncoding-rna-transcript-and-rs6983267-single-nucleotide-polymorphism-genotypes-in-colorectal-cancers
#12
Yuta Kasagi, Eiji Oki, Koji Ando, Shuhei Ito, Tomohiro Iguchi, Masahiko Sugiyama, Yuichiro Nakashima, Kippei Ohgaki, Hiroshi Saeki, Koshi Mimori, Yoshihiko Maehara
Colon cancer-associated transcription 2 (CCAT2) was recently identified as a novel long noncoding RNA transcript encompassing the single-nucleotide polymorphism rs6983267. CCAT2 is overexpressed in colorectal cancer (CRC) where it promotes tumor growth, metastasis, and chromosomal instability, although the clinical relevance of this enhanced expression is unknown. In this retrospective study, CCAT2 expression was evaluated using real-time polymerase chain reaction in 149 CRC patients, and its associations with clinicopathological characteristics, outcome, rs6983267 genotypes, microsatellite status, DNA ploidy, and BubR1 expression were analyzed...
November 23, 2016: Oncology
https://www.readbyqxmd.com/read/27874951/high-expression-of-long-noncoding-rna-sox2ot-is-associated-with-the-aggressive-progression-and-poor-outcome-of-gastric-cancer
#13
J-H Zou, C-Y Li, J Bao, G-Q Zheng
OBJECTIVE: The aim of our study was to investigate the expression of long non-coding RNA Sox2ot (Sox2ot) in gastric cancer (GC) patients and its association with clinicopathologic parameters and the prognosis. PATIENTS AND METHODS: Quantitative real-time polymerase chain reaction was performed to detect Sox2ot expression in 155 GC tissues and paired adjacent normal tissues. The relationships between Sox2ot expression and the clinicopathological features of GC patients were analyzed...
November 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27872311/methyltransferase-like-protein-16-binds-the-3-terminal-triple-helix-of-malat1-long-noncoding-rna
#14
Jessica A Brown, Charles G Kinzig, Suzanne J DeGregorio, Joan A Steitz
Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), a cancer-promoting long noncoding RNA, accumulates in cells by using a 3'-triple-helical RNA stability element for nuclear expression (ENE). The ENE, a stem-loop structure containing a U-rich internal loop, interacts with a downstream A-rich tract (ENE+A) to form a blunt-ended triple helix composed of nine U•A-U triples interrupted by a C•G-C triple and C-G doublet. This unique structure prompted us to explore the possibility of protein binding...
November 21, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27871336/zfas1-a-long-noncoding-rna-associated-with-ribosomes-in-breast-cancer-cells
#15
Herah Hansji, Euphemia Y Leung, Bruce C Baguley, Graeme J Finlay, David Cameron-Smith, Vandre C Figueiredo, Marjan E Askarian-Amiri
BACKGROUND: Most of the eukaryotic genome is transcribed, yielding a complex network of transcripts including thousands of lncRNAs that generally lack protein coding potential. However, only a small percentage of these molecules has been functionally characterised, and discoveries of specific functions demonstrate layers of complexity. A large percentage of lncRNAs is located in the cytoplasm, associated with ribosomes but the function of the majority of these transcripts is unclear. The current study analyses putative mechanisms of action of the lncRNA species member ZFAS1 that was initially discovered by microarray analysis of murine tissues undergoing mammary gland development...
November 21, 2016: Biology Direct
https://www.readbyqxmd.com/read/27871067/the-lncrna-snhg5-mir-32-axis-regulates-gastric-cancer-cell-proliferation-and-migration-by-targeting-klf4
#16
Lianmei Zhao, Taotao Han, Yanshuang Li, Jiazeng Sun, Shang Zhang, Yanxin Liu, Baoen Shan, Dexian Zheng, Juan Shi
Long noncoding RNAs (lncRNAs) are emerging as important regulators in cellular processes, including the development, proliferation, and migration of cancer cells. We have demonstrated in a prior study that small nucleolar RNA host gene 5 (SNHG5) is dysregulated in gastric cancer (GC). To further explore the underlying mechanisms of SNGH5 function in the development of GC, in this study, we screened the microRNAs interacting with SNHG5 and elucidated their roles in GC. We showed that SNHG5 contains a putative miR-32-binding site and that deletion of this site abolishes the responsiveness to miR-32...
November 21, 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/27865468/molecular-and-cellular-changes-in-breast-cancer-and-new-roles-of-lncrnas-in-breast-cancer-initiation-and-progression
#17
M Kumar, R S DeVaux, J I Herschkowitz
Breast cancer is not just one disease but many variations on a theme, comprising a variety of molecular subtypes with distinct etiologies, cellular origins, treatment strategies, and prognoses. Like mRNAs and microRNAs (miRNAs), long noncoding RNAs (lncRNAs) differ dramatically in expression across breast cancer subtypes and can be used for classification. While there has been considerable emphasis on miRNAs, our knowledge is still in its infancy about the role of lncRNAs that comprise the majority of the mammalian transcriptome...
2016: Progress in Molecular Biology and Translational Science
https://www.readbyqxmd.com/read/27863388/comprehensive-analysis-of-aberrantly-expressed-profiles-of-lncrnas-and-mirnas-with-associated-cerna-network-in-muscle-invasive-bladder-cancer
#18
Hanbo Wang, Leilei Niu, Shaobo Jiang, Jing Zhai, Ping Wang, Feng Kong, Xunbo Jin
Although initially thought to be transcriptional noise, long noncoding RNAs (lncRNAs) are gaining increased attention in human cancers as its diversity function. At present, lncRNAs are regarded as the main part of competing endogenous RNA (ceRNA) network due to its regulation on protein-coding gene expression by acting as miRNA sponges. However, functional roles of lncRNA-mediated ceRNAs in muscle-invasive bladder cancer remain unclear. To clarify relevant potential mechanisms, here we comprehensively compared the expression profiles of mRNAs, lncRNAs and miRNAs between 322 muscle-invasive bladder cancer tissues and 19 non-tumor bladder tissues, based on the Cancer Genome Atlas (TCGA)...
November 15, 2016: Oncotarget
https://www.readbyqxmd.com/read/27862275/long-noncoding-rna-zfas1-promotes-the-progression-of-colonic-cancer-by-modulating-zeb1-expression
#19
Changyi Fang, Jianbao Zan, Ben Yue, Chenchen Liu, Chenglong He, Dongwang Yan
BACKGROUND AND AIM: Long non-coding RNA ZFAS1 (zinc finger antisense 1) is frequently amplified in hepatocellular carcinoma and promotes metastasis by increasing zinc finger E-box binding homeobox 1 (ZEB1), which can potentiate the progression of epithelial-to-mesenchymal transition (EMT). However, the expression pattern and role of ZFAS1 in colonic cancer remains unknown. The present study aimed to investigate the role of ZFAS1 and its clinical significance in colonic cancer. METHODS: Paired clinical colonic cancer tissue samples and clinicopathologic characteristics of 73 patients were analyzed...
November 11, 2016: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27855392/the-emerging-roles-of-long-noncoding-rna-ror-lincrna-ror-and-its-possible-mechanisms-in-human-cancers
#20
Yan Pan, Chen Li, Jing Chen, Kai Zhang, Xiaoyuan Chu, Rui Wang, Longbang Chen
To date, there is only up to 2% of protein-coding genes that are stably transcribed, whereas the vast majority are non-coding RNAs (ncRNAs). These ncRNAs, also known as non-messenger RNAs (nmRNAs) or functional RNAs (fRNAs), include transfer RNAs, ribosomal RNAs, microRNAs and long non-coding RNAs (lncRNAs). With the advance of high-resolution microarrays and massively parallel sequencing technology, lncRNAs have gained extended attentions nowadays and are found to play important roles in tumorigenesis and progression of human cancers...
2016: Cellular Physiology and Biochemistry
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