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https://www.readbyqxmd.com/read/28106228/expression-of-long-non-coding-rna-pandar-and-its-prognostic-value-in-colorectal-cancer-patients
#1
Xiangke Li, Feng Wang, Yan Sun, Qingxia Fan, Guangfei Cui
BACKGROUND: Long noncoding RNAs (lncRNAs) are emerging as key molecules in human cancer. In the present study, we explored the role of the lncRNA PANDAR in colorectal cancer (CRC). METHODS: The relative expression level of lncRNA PANDAR in CRC tissues and cell lines was determined by quantitative real-time polymerase chain reaction (qRT-PCR). The associations between PANDAR expression and clinicopathological features of CRC patients were further analyzed. Kaplan-Meier survival analysis was performed to evaluate the value of PANDAR in the prognosis of CRC patients...
January 20, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28105199/serum-microrna-17-functions-as-a-prognostic-biomarker-in-osteosarcoma
#2
Shuai Li, Yong Gao, Yan Wang, Kun Wang, Zhi-Peng Dai, Dong Xu, Wei Liu, Zhi-Liang Li, Zheng-Dong Zhang, Shu-Hua Yang, Cao Yang
MicroRNAs (miRNAs/miRs) are a class of small noncoding RNA molecules that have important roles in regulating the expression of target genes associated with the development and progression of cancer. The majority of miRNAs are expressed in a highly tissue- and region-specific manner, and released into the bloodstream as a consequences of different diseases. Furthermore, altered levels of miRNAs have been observed in several diseases, including cancer. In the present study, reverse transcription-quantitative polymerase chain reaction (RT-qPCR) demonstrated that circulating miR-17 levels were significantly upregulated in patients with osteosarcoma (OS) compared with healthy subjects...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28103507/circular-banp-an-upregulated-circular-rna-that-modulates-cell-proliferation-in-colorectal-cancer
#3
Mingchen Zhu, Yijun Xu, Yun Chen, Feng Yan
Circular RNAs (circRNAs) are recently identified as widespread and diverse endogenous noncoding RNAs that may harbor vital functions in human and animals. However, the role of circRNAs in the process of tumorigenesis and development of colorectal cancer (CRC) remains vague. Here we characterized the circRNA expression profile from three paired CRC cancerous and adjacent normal tissues by human circRNA array, and identified 136 significantly overexpressed circRNAs and 243 downregulated circRNAs in CRC cancerous tissues (>2-fold changes)...
January 16, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28102845/h19-let-7-lin28-reciprocal-negative-regulatory-circuit-promotes-breast-cancer-stem-cell-maintenance
#4
Fei Peng, Ting-Ting Li, Kai-Li Wang, Guo-Qing Xiao, Ju-Hong Wang, Hai-Dong Zhao, Zhi-Jie Kang, Wen-Jun Fan, Li-Li Zhu, Mei Li, Bai Cui, Fei-Meng Zheng, Hong-Jiang Wang, Eric W-F Lam, Bo Wang, Jie Xu, Quentin Liu
Long noncoding RNA-H19 (H19), an imprinted oncofetal gene, has a central role in carcinogenesis. Hitherto, the mechanism by which H19 regulates cancer stem cells, remains elusive. Here we show that breast cancer stem cells (BCSCs) express high levels of H19, and ectopic overexpression of H19 significantly promotes breast cancer cell clonogenicity, migration and mammosphere-forming ability. Conversely, silencing of H19 represses these BCSC properties. In concordance, knockdown of H19 markedly inhibits tumor growth and suppresses tumorigenesis in nude mice...
January 19, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28089750/long-noncoding-rna-ccat2-can-predict-metastasis-and-poor-prognosis-a-meta-analysis
#5
REVIEW
Yang-Hua Fan, Hua Fang, Chen-Xing Ji, Huan Xie, Bing Xiao, Xin-Gen Zhu
BACKGROUND: It has been reported that Colon cancer-associated transcript 2 (CCAT2) is dysregulated in various cancers. We performed this meta-analysis to clarify its promising functions as a prognosis marker in malignant tumors. METHODS: Electronic databases, including PubMed, Medline, OVID, Cochrane Library, and Web of Science, were searched from inception to October 20, 2016. The hazard ratio (HR) and 95% confidence interval (CI) were calculated to explore the relationship between CCAT2 expression and survival, which were extracted from the eligible studies...
January 13, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28088836/upregulation-of-long-noncoding-rna-tug1-promotes-cervical-cancer-cell-proliferation-and-migration
#6
Yingying Hu, Xiangwei Sun, Chenchen Mao, Gangqiang Guo, Sisi Ye, Jianfeng Xu, Ruanmin Zou, Jun Chen, Ledan Wang, Ping Duan, Xiangyang Xue
Long noncoding RNAs (lncRNAs), a novel class of transcripts that have critical roles in carcinogenesis and progression, have emerged as important gene expression modulators. Recent evidence indicates that lncRNA taurine-upregulated gene 1 (TUG1) functions as an oncogene in numerous types of human cancers. However, its function in the development of cervical cancer remains unknown. The aim of this research was to investigate the clinical significance and biological functions of TUG1 in cervical cancer. TUG1 was found to be significantly upregulated in cervical cancer tissues and four cervical cancer cell lines by quantitative real-time polymerase chain reaction (qRT-PCR)...
January 15, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28079712/a-comprehensive-review-of-genomics-and-noncoding-rna-in-gliomas
#7
Ahmed Hassan, Jennifer Mosley, Sanjay Singh, Pascal Olivier Zinn
Glioblastoma (GBM) is the most malignant primary adult brain tumor. In spite of our greater understanding of the biology of GBMs, clinical outcome of GBM patients remains poor, as their median survival with best available treatment is 12 to 18 months. Recent efforts of The Cancer Genome Atlas (TCGA) have subgrouped patients into 4 molecular/transcriptional subgroups: proneural, neural, classical, and mesenchymal. Continuing efforts are underway to provide a comprehensive map of the heterogeneous makeup of GBM to include noncoding transcripts, genetic mutations, and their associations to clinical outcome...
January 11, 2017: Topics in Magnetic Resonance Imaging: TMRI
https://www.readbyqxmd.com/read/28075173/tgf%C3%AE-1-induced-lncrna-uca1-upregulation-promotes-gastric-cancer-invasion-and-migration
#8
Zhong-Kun Zuo, Yi Gong, Xiang-Heng Chen, Fei Ye, Zheng-Ming Yin, Qian-Ni Gong, Jiang-Sheng Huang
According to recent studies, long noncoding RNA urothelial carcinoma associated 1 (UCA1) is involved in the development and progression of many malignant tumors, including gastric cancer (GC). We validated the detailed role of UCA1 in human GC cell lines and GC tissues so as to determine its exact function and the underlying mechanism of GC invasion and migration. In our research, lncRNA-UCA1 was specifically upregulated in GC tissues and cell lines, and augmented GC cell proliferation, and invasive and migratory capabilities...
January 11, 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/28075045/interplay-between-long-noncoding-rna-zeb1-as1-and-mir-200s-regulates-osteosarcoma-cell-proliferation-and-migration
#9
Chibo Liu, Chunqin Pan, Yanqun Cai, Haibao Wang
In our previous study we found long noncoding RNA ZEB1-AS1 is upregulated and functions as an oncogene in osteosarcoma. MiR-200 family (miR-200s) functions as tumor suppressor via directly targeting ZEB1 in various cancers. In this study we further investigate the potential interplay between ZEB1-AS1, miR-200s, and ZEB1 in osteosarcoma. Our results showed that ZEB1-AS1 functions as a molecular sponge for miR-200s and relieves the inhibition of ZEB1 caused by miR-200s. ZEB1-AS1 and miR-200s reciprocally negatively regulate each other...
January 11, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28069548/long-noncoding-rna-hulc-promotes-cell-proliferation-by-regulating-pi3k-akt-signaling-pathway-in-chronic-myeloid-leukemia
#10
Yinghao Lu, Yan Li, Xiao Chai, Qian Kang, Peng Zhao, Jie Xiong, Jishi Wang
Aberrant expression of long noncoding RNA (lncRNA) HULC is associated with various human cancers. However, the role of HULC in chronic myeloid leukemia (CML) is unknown. In this study, we found that HULC was remarkably overexpressed in both leukemia cell lines and primary hematopoietic cells derived from CML patients. The increase in HULC expression was positively correlated with clinical stages in CML. Moreover, the knockdown of HULC significantly inhibited CML cell proliferation and induced apoptosis by repressing c-Myc and Bcl-2...
January 6, 2017: Gene
https://www.readbyqxmd.com/read/28066612/elevated-hotair-expression-associated-with-cisplatin-resistance-in-non-small-cell-lung-cancer-patients
#11
Ming-Yue Liu, Xi-Qing Li, Tian-Hui Gao, Yao Cui, Ning Ma, Yun Zhou, Guo-Jun Zhang
BACKGROUND: This study investigated the mechanism of drug resistance in non-small cell lung cancer (NSCLC) patients. We specifically studied whether long noncoding RNAs influence drug resistance in NSCLC to discover new therapeutic targets to increase the survival rate of drug-resistant NSCLC patients. METHODS: Tissue samples were collected from NSCLC patients, and total RNA was isolated for assessment of HOTAIR expression and drug resistance status. MTT assays, tumor sphere formation assays, and western blot were performed to cytologically determine the relationship between HOTAIR expression and cisplatin resistance, as well as to elucidate the potential molecular mechanism involved...
November 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28063065/effects-of-long-noncoding-rna-ror-on-tamoxifen-resistance-of-breast-cancer-cells-by-regulating-microrna-205
#12
Hong-Yan Zhang, Feng Liang, Jian-Wei Zhang, Fei Wang, Li Wang, Xi-Gang Kang
PURPOSE: To explore how long noncoding RNA-ROR (lncRNA-ROR) affects the tamoxifen resistance of breast cancer cells. METHODS: Breast epithelial (MCF10A), breast cancer (MCF7), and natural tamoxifen-resistant breast cancer (MDA-MB-231) cell lines were selected, and the relative lncRNA-ROR expressions were detected using quantitative real-time polymerase chain reaction (qRT-PCR). In vitro induction of TR5 cell line was performed. There were six groups: MCF7, MCF7/TR5, MDA-MB-231, MCF7-ROR, MCF7/TR5 ROR-siRNA, and the MDA-MB-231 ROR-siRNA groups...
January 6, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28059053/long-noncoding-rna-gas5-suppresses-tumorigenesis-by-inhibiting-mir-23a-5-expression-in-non-small-cell-lung-cancer
#13
Yongcheng Mei, Jinchun Si, Yun Wang, Zhuangshi Huang, Haiwen Zhu, Shijun Feng, Xuezhi Wu, Liwen Wu
Previous studies reported that elevated expression of long noncoding RNA GAS5 led to NSCLC cell growth arrest and a promotion of apoptosis both <em>in vitro</em> and <em>in vivo</em>. However, its underlying molecular mechanism in NSCLC is still unclear. In the present study, we noted that GAS5 was down-regulated in NSCLC tissues and cells and was negatively correlated with miR-23a expression. Luciferase reporter assay and qRT-PCR analysis demonstrated that GAS5 directly interacted with miR-23a and reversely regulate its expression...
January 5, 2017: Oncology Research
https://www.readbyqxmd.com/read/28057015/downregulation-of-long-noncoding-rna-meg3-is-associated-with-poor-prognosis-and-promoter-hypermethylation-in-cervical-cancer
#14
Jun Zhang, Zhongqiu Lin, Yali Gao, Tingting Yao
BACKGROUND: Our previous study reported that MEG3 is an important tumor suppressor gene that is inactivated in cervical cancer. However, the diagnostic and prognostic values of MEG3, as well as the molecular mechanism of MEG3 inactivation in cervical cancer, remain unclear. In this study, we aimed to further elucidate the role and potential inactivation mechanism of MEG3 in cervical cancer. METHODS: ROC curve and Cox regression analyses were used to assess the diagnostic and prognostic value of MEG3 in patients with cervical cancer...
January 5, 2017: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/28053545/high-expression-of-long-noncoding-rna-hulc-is-a-poor-predictor-of-prognosis-and-regulates-cell-proliferation-in-glioma
#15
Hong Yan, Rui Tian, Min Zhang, Jing Wu, Min Ding, Jie He
PURPOSE: Emerging studies show that long noncoding RNAs (lncRNAs) have important roles in carcinogenesis. This study investigated the role of lncRNA highly upregulated in liver cancer (HULC) expression in glioma and its clinical significance in glioma patients. MATERIALS AND METHODS: HULC expression was detected in glioma tissues and cell lines by using real-time quantitative reverse transcription polymerase chain reactions. Association between HULC levels and clinicopathological factors and patients prognosis was also analyzed...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28052821/micrornas-and-their-impact-on-breast-cancer-the-tumor-microenvironment-and-disparities
#16
A Evans-Knowell, A C LaRue, V J Findlay
Breast cancer is a worldwide health issue as it represents the leading cause of cancer in women and the second-leading cause of cancer-related mortality in women, with an increasing incidence. Nothing speaks more clearly to the shocking breast cancer health disparities than the fact that African American (AA) women are as likely to get breast cancer as Caucasian American (CA) women, yet have a higher breast cancer death rate. It is becoming increasingly apparent that racial disparity in cancer exists due to molecular differences in tumor biology as well as, or in addition to, socioeconomic and standard of care issues (Albain, Unger, Crowley, Coltman, & Hershman, 2009)...
2017: Advances in Cancer Research
https://www.readbyqxmd.com/read/28052018/targeting-micrornas-a-new-action-mechanism-of-natural-compounds
#17
REVIEW
Qian Lin, Leina Ma, Zhantao Liu, Zhihong Yang, Jin Wang, Jia Liu, Guohui Jiang
Unlike genetics, epigenetics involves the modification of genome without changes in DNA sequences, including DNA methylation, histone modification, chromatin remodeling and noncoding RNA regulation. MicroRNA (miRNA), a member of noncoding RNAs superfamily, participates in RNA interference through a unique mechanism. Currently, microRNAs have been found to be regulated by some natural compounds. Through altering the expression of miRNAs and influencing the downstream signaling pathways or target genes, several natural compounds exhibit its bioactivity in the prevention, diagnosis, therapy, prognosis and drug resistance of human diseases, such as cancer...
December 30, 2016: Oncotarget
https://www.readbyqxmd.com/read/28051258/overexpression-of-long-noncoding-rna-zfas1-decreases-survival-in-human-nsclc-patients
#18
F-M Tian, F-Q Meng, X-B Wang
OBJECTIVE: The purpose of the current study was to characterize the expression of long-noncoding-RNA ZFAS1 (ZFAS1) and assess the clinical significance of ZFAS1 in non-small cell lung cancer (NSCLC). PATIENTS AND METHODS: A total of 173 patients with NSCLC were addressed in the present retrospective study. Expression levels of ZFAS1 were detected by quantitative real-time PCR. We further analyzed the correlation between ZFAS1 and clinicopathologic features of NSCLC with X2-test...
December 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28049826/myh9-binds-to-lncrna-gene-ptcsc2-and-regulates-foxe1-in-the-9q22-thyroid-cancer-risk-locus
#19
Yanqiang Wang, Huiling He, Wei Li, John Phay, Rulong Shen, Lianbo Yu, Baris Hancioglu, Albert de la Chapelle
A locus on chromosome 9q22 harbors a SNP (rs965513) firmly associated with risk of papillary thyroid carcinoma (PTC). The locus also comprises the forkhead box E1 (FOXE1) gene, which is implicated in thyroid development, and a long noncoding RNA (lncRNA) gene, papillary thyroid cancer susceptibility candidate 2 (PTCSC2). How these might interact is not known. Here we report that PTCSC2 binds myosin-9 (MYH9). In a bidirectional promoter shared by FOXE1 and PTCSC2, MYH9 inhibits the promoter activity in both directions...
January 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28049499/circular-rnas-in-cancer-an-emerging-key-player
#20
REVIEW
Yeping Dong, Dan He, Zhenzi Peng, Wei Peng, Wenwen Shi, Jun Wang, Bin Li, Chunfang Zhang, Chaojun Duan
Circular RNAs (circRNAs) are a class of endogendous RNAs that form a covalently closed continuous loop and exist extensively in mammalian cells. Majority of circRNAs are conserved across species and often show tissue/developmental stage-specific expression. CircRNAs were first thought to be the result of splicing error; however, subsequent research shows that circRNAs can function as microRNA (miRNA) sponges and regulate splicing and transcription. Emerging evidence shows that circRNAs possess closely associated with human diseases, especially cancers, and may serve as better biomarkers...
January 3, 2017: Journal of Hematology & Oncology
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